ReportWire

Tag: Vaccines

  • Why Polio Has Reemerged in Gaza

    Why Polio Has Reemerged in Gaza

    Why are most cases of polio vaccine-derived variants?

    Most cases of paralytic polio are now vaccine-derived due to the success of the Global Polio Eradication Initiative. OPV has been instrumental in the near-eradication of wild polioviruses around the world. However, in areas where vaccination rates drop and enough people are susceptible to infection, the weakened virus can replicate. Unfortunately, each round of replication increases the potential for the virus to revert to a form that causes illness and paralysis.

    Why was the old oral polio vaccine shelved in 2016?

    Following the eradication of type 2 poliovirus in 1999, the only cases of type 2 paralytic polio were vaccine derived. Therefore, to stop these cases, there was a decision to shift from the original trivalent OPV, which contained all three poliovirus serotypes, to a bivalent OPV vaccine, which only contained type 1 and type 3 poliovirus strains. With an additional type 2 specific monovalent vaccine available to contain any vaccine-derived type 2 should any cases arise.

    Was that a mistake, as some experts have suggested?

    Although this decision was well intentioned, hindsight suggests that the level of vaccine-derived type 2 poliovirus was underestimated. The Global Polio Eradication Initiative commissioned a report into this decision and the draft report, which is open for public comment, has described the switch to bivalent OPV as an “unqualified failure”.

    What type of poliovirus vaccine is being used in the current campaign in Gaza?

    More than 1.6 million doses of the novel oral poliovirus vaccine type 2 (nOPV2) – a new poliovirus vaccine—will be delivered to the Gaza Strip to provide two doses to more than 640,000 children under the age of 10.

    Will it have the same risks as the old poliovirus vaccine? That is, might it get in the wastewater and cause more polio cases?

    No, the nOPV2 is a next-generation version of the traditional type 2 monovalent oral polio vaccine that is used to respond to vaccine-derived type 2 poliovirus outbreaks. The key difference is that the new vaccine contains a weakened virus that has been modified to make it more genetically stable and significantly less likely to revert to a more virulent form capable of causing paralysis, thereby increasing the chances of stopping these outbreaks for good.

    What other diseases are likely to emerge in Gaza, given the interrupted vaccination campaigns?

    Other vaccine-preventable diseases, such as measles and pneumonia, as well as diarrheal diseases, such as rotavirus, all have the potential to emerge, each with its own dangers and complications. Therefore it is really important that as many vaccines as possible are delivered into Gaza.

    Lee Sherry

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  • Minnesota facing growing number of measles cases

    Minnesota facing growing number of measles cases

    MINNEAPOLIS, Minn. — Measles is much more than a rash. It can lead to deafness, brain damage and death. 

    The Minnesota Department of Health has reported 46 cases of measles in the state so far this year, which is the most since 2017. 

    46 may not sound like a lot, but infectious disease experts are worried. 

    “We are all very terrified that this is just going to explode because we have such low vaccination rates in certain pockets of our population, which put a lot of kids at risk,” said Dr. Stacene Maroushek, pediatric infectious disease specialist with Hennepin Healthcare. 

    As a result, MDH is accelerating vaccine recommendations. 

    Normally, one measles, mumps and rubella vaccine is given when a child is one year old and a second when the child is four. Now, MDH recommends the second dose one month after the first. 

    The department is not breaking down the cases by ethnicity, but they do say measles is spreading in unvaccinated children in the Somali community. For years in that community, there have been false and unfounded reports that the vaccine is linked to autism.

    “There have been millions of dollars in many studies done to basically debunk that,” said Dr. Maroushek. 

    Saed Yusuf says his five children are all fully vaccinated. Yusef is a registered nurse and clinical supervisor at Hennepin Health, and he’s a Somali American. 

    “I would say overall, it’s just lack of awareness and misconception, misunderstanding and also lack of education,” Yusuf said.

    Only 24% of Somali American children in Minnesota have both measles shots. That compares to 87% of others in the population, which experts say is also a dangerously low number. 

    According to the CDC, measles is considered one of the most contagious of all diseases. The virus can remain active in the air and on surfaces for two hours. 

    Esme Murphy

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  • The United Nations’ ambitious plan to vaccinate Gaza against polio

    The United Nations’ ambitious plan to vaccinate Gaza against polio

    The United Nations health agency and partners are launching a campaign starting Sunday to vaccinate 640,000 Palestinian children in Gaza against polio, an ambitious effort amid a devastating war that has destroyed the territory’s health care system.Related video above: 6 Israeli hostages’ bodies recovered amid Blinken’s ceasefire effortsThe campaign comes after the first polio case was reported in Gaza in 25 years — a 10-month-old boy, now paralyzed in the leg. The World Health Organization says the presence of a paralysis case indicates there could be hundreds more who have been infected but aren’t showing symptoms.Most people who have polio do not experience symptoms and those who do usually recover in a week or so. But there is no cure, and when polio causes paralysis, it is usually permanent. If the paralysis affects breathing muscles, the disease can be fatal.The vaccination effort will not be easy: Gaza’s roads are largely destroyed, its hospitals badly damaged, and its population spread into isolated pockets.WHO said Thursday that it has reached an agreement with Israel for limited pauses in the fighting to allow for the vaccination campaign to take place. Even so, such a large-scale campaign will pose major difficulties in a territory blanketed in rubble, where 90% of Palestinians are displaced.How long will it take?The three-day vaccination campaign in central Gaza will begin Sunday, during a “humanitarian pause” lasting from 6 a.m. until 3 p.m., and another day can be added if needed, said Dr. Rik Peeperkorn, WHO’s representative in the Palestinian territories.In coordination with Israeli authorities, the effort will then move to southern Gaza and northern Gaza during similar pauses, he said during a news conference by video from Deir al-Balah in central Gaza.Who will receive the vaccine?The vaccination campaign targets 640,000 children under 10, according to WHO. Each child will receive two drops of oral polio vaccine in two rounds, the second to be administered four weeks after the first.Where are the vaccination sites?The vaccination sites span Gaza, both inside and outside Israeli evacuation zones, from Rafah in the south to the northern reaches of the territory.The Ramallah-based Health Ministry said Friday that there would be over 400 “fixed” vaccination sites — the most in Khan Younis, where the population density is the highest and there are 239,300 children under 10. Fixed sites include health care centers, hospitals, clinics and field hospitals.Elsewhere in the territory, there will also be around 230 “outreach” sites — community gathering points that are not traditional medical centers — where vaccines will be distributed.Where are the vaccines now?Around 1.3 million doses of the vaccine traveled through the Kerem Shalom checkpoint and are currently being held in “cold-chain storage” in a warehouse in Deir al-Balah. That means the warehouse is able to maintain the correct temperature so the vaccines do not lose their potency.Another shipment of 400,000 doses is set to be delivered to Gaza soon.The vaccines will be trucked to distribution sites by a team of over 2,000 medical volunteers, said Ammar Ammar, a spokesperson for UNICEF.What challenges lie ahead?Mounting any sort of campaign that requires traversing the Gaza Strip and interacting with its medical system is bound to pose difficulties.The U.N. estimates that approximately 65% of the total road network in Gaza has been damaged. Nineteen of the strip’s 36 hospitals are out of service.The north of the territory is cut off from the south, and travel between the two areas has been challenging throughout the war because of Israeli military operations. Aid groups have had to suspend trips due to security concerns, after convoys were targeted by the Israeli military.Peeperkorn said Friday that WHO cannot do house-to-house vaccinations in Gaza, as they have in other polio campaigns. When asked about the viability of the effort, Peeperkorn said WHO thinks “it is feasible if all the pieces of the puzzle are in place. “How many doses do children need and what happens if they miss a dose?The World Health Organization says children typically need about three to four doses of oral polio vaccine — two drops per dose — to be protected against polio. If they don’t receive all of the doses, they are vulnerable to infection.Doctors have previously found that children who are malnourished or who have other illnesses might need more than 10 doses of the oral polio vaccine to be fully protected.Are there side effects?Yes, but they are very rare.Billions of doses of the oral vaccine have been given to children worldwide, and it is safe and effective. But in about 1 in 2.7 million doses, the live virus in the vaccine can paralyze the child who receives the drops.How did this outbreak in Gaza start?The polio virus that triggered this latest outbreak is a mutated virus from an oral polio vaccine. The oral polio vaccine contains weakened live virus, and in very rare cases, that virus is shed by those who are vaccinated and can evolve into a new form capable of starting new epidemics.___Associated Press reporters Samy Magdy in Cairo and Maria Cheng in London contributed.

    The United Nations health agency and partners are launching a campaign starting Sunday to vaccinate 640,000 Palestinian children in Gaza against polio, an ambitious effort amid a devastating war that has destroyed the territory’s health care system.

    Related video above: 6 Israeli hostages’ bodies recovered amid Blinken’s ceasefire efforts

    The campaign comes after the first polio case was reported in Gaza in 25 years — a 10-month-old boy, now paralyzed in the leg. The World Health Organization says the presence of a paralysis case indicates there could be hundreds more who have been infected but aren’t showing symptoms.

    Most people who have polio do not experience symptoms and those who do usually recover in a week or so. But there is no cure, and when polio causes paralysis, it is usually permanent. If the paralysis affects breathing muscles, the disease can be fatal.

    The vaccination effort will not be easy: Gaza’s roads are largely destroyed, its hospitals badly damaged, and its population spread into isolated pockets.

    WHO said Thursday that it has reached an agreement with Israel for limited pauses in the fighting to allow for the vaccination campaign to take place. Even so, such a large-scale campaign will pose major difficulties in a territory blanketed in rubble, where 90% of Palestinians are displaced.

    How long will it take?

    The three-day vaccination campaign in central Gaza will begin Sunday, during a “humanitarian pause” lasting from 6 a.m. until 3 p.m., and another day can be added if needed, said Dr. Rik Peeperkorn, WHO’s representative in the Palestinian territories.

    In coordination with Israeli authorities, the effort will then move to southern Gaza and northern Gaza during similar pauses, he said during a news conference by video from Deir al-Balah in central Gaza.

    Who will receive the vaccine?

    The vaccination campaign targets 640,000 children under 10, according to WHO. Each child will receive two drops of oral polio vaccine in two rounds, the second to be administered four weeks after the first.

    Where are the vaccination sites?

    The vaccination sites span Gaza, both inside and outside Israeli evacuation zones, from Rafah in the south to the northern reaches of the territory.

    The Ramallah-based Health Ministry said Friday that there would be over 400 “fixed” vaccination sites — the most in Khan Younis, where the population density is the highest and there are 239,300 children under 10. Fixed sites include health care centers, hospitals, clinics and field hospitals.

    Elsewhere in the territory, there will also be around 230 “outreach” sites — community gathering points that are not traditional medical centers — where vaccines will be distributed.

    Where are the vaccines now?

    Around 1.3 million doses of the vaccine traveled through the Kerem Shalom checkpoint and are currently being held in “cold-chain storage” in a warehouse in Deir al-Balah. That means the warehouse is able to maintain the correct temperature so the vaccines do not lose their potency.

    Another shipment of 400,000 doses is set to be delivered to Gaza soon.

    The vaccines will be trucked to distribution sites by a team of over 2,000 medical volunteers, said Ammar Ammar, a spokesperson for UNICEF.

    What challenges lie ahead?

    Mounting any sort of campaign that requires traversing the Gaza Strip and interacting with its medical system is bound to pose difficulties.

    The U.N. estimates that approximately 65% of the total road network in Gaza has been damaged. Nineteen of the strip’s 36 hospitals are out of service.

    The north of the territory is cut off from the south, and travel between the two areas has been challenging throughout the war because of Israeli military operations. Aid groups have had to suspend trips due to security concerns, after convoys were targeted by the Israeli military.

    Peeperkorn said Friday that WHO cannot do house-to-house vaccinations in Gaza, as they have in other polio campaigns. When asked about the viability of the effort, Peeperkorn said WHO thinks “it is feasible if all the pieces of the puzzle are in place. “

    How many doses do children need and what happens if they miss a dose?

    The World Health Organization says children typically need about three to four doses of oral polio vaccine — two drops per dose — to be protected against polio. If they don’t receive all of the doses, they are vulnerable to infection.

    Doctors have previously found that children who are malnourished or who have other illnesses might need more than 10 doses of the oral polio vaccine to be fully protected.

    Are there side effects?

    Yes, but they are very rare.

    Billions of doses of the oral vaccine have been given to children worldwide, and it is safe and effective. But in about 1 in 2.7 million doses, the live virus in the vaccine can paralyze the child who receives the drops.

    How did this outbreak in Gaza start?

    The polio virus that triggered this latest outbreak is a mutated virus from an oral polio vaccine. The oral polio vaccine contains weakened live virus, and in very rare cases, that virus is shed by those who are vaccinated and can evolve into a new form capable of starting new epidemics.

    ___

    Associated Press reporters Samy Magdy in Cairo and Maria Cheng in London contributed.


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  • Promising Mpox Drug Fails in Trials as Virus Spreads

    Promising Mpox Drug Fails in Trials as Virus Spreads

    As mpox continues to spread in Central Africa, a promising antiviral drug to treat the infection has failed to improve patients’ symptoms in a trial in the Democratic Republic of the Congo, the epicenter of the outbreak.

    In the trial, the drug tecovirimat, also known as TPOXX, did not alleviate the characteristic blisterlike rash seen in people with mpox, formerly known as monkeypox. In an unusual step, the US National Institute of Allergy and Infectious Diseases (NIAID), which sponsored the study, announced the initial findings earlier this month prior to the full results being peer reviewed and published in a scientific journal.

    Lori Dodd, branch chief of NIAID’s clinical trials research and statistics branch, tells WIRED that the agency shared the initial results “due to the urgent need for scientific evidence on the use of tecovirimat for the treatment of mpox.” That urgency, she says, was reinforced by the World Health Organization designating the mpox outbreak in Central Africa as a global health emergency on August 14. It’s the second such declaration in two years.

    The results come as a disappointment, especially as Central African countries are struggling to contain transmission of mpox. Since the beginning of this year, 13 African countries have recorded a total of 20,720 confirmed or suspected cases of mpox and 582 deaths, according to an August 25 report from the Africa Centres for Disease Control and Prevention.

    On Monday, the World Health Organization launched a six-month strategic plan aimed at reining in the outbreak. The plan, which is estimated to cost $135 million, includes boosting surveillance efforts, as well as improving access to testing and vaccines. “The mpox outbreaks in the Democratic Republic of the Congo and neighboring countries can be controlled, and can be stopped,” said Tedros Adhanom Ghebreyesus, WHO Director-General, in a statement.

    There are approved vaccines to prevent mpox but no drugs indicated to treat the disease. Tecovirimat was approved by the US Food and Drug Administration in 2018 for the treatment of smallpox, a related virus, and ongoing trials of the drug were launched in 2022 to treat mpox amid a global outbreak of the disease. The drug has also been available in the US for mpox through an expanded access program, which allows a physician to treat a patient with an investigational drug outside of a clinical trial. In the UK and Europe, TPOXX was approved for mpox under exceptional circumstances without comprehensive data on its efficacy.

    As part of the trial in the DRC, nearly 600 participants were randomly assigned to receive tecovirimat or a placebo and were admitted to a hospital for at least 14 days, where they were monitored closely. All participants received supportive care, which included nutrition, hydration, and treatment for any secondary infections. While the drug was found to be safe, it was no better at clearing up patients’ lesions than the placebo.

    Notably, mortality was lower, and patients’ lesions cleared up faster than anticipated regardless of whether they received tecovirimat or placebo. The study’s 1.7 percent overall mortality among enrollees, regardless of whether they received the drug or not, was much lower than the mpox mortality of 3.6 percent or higher reported among all cases in the DRC.

    Emily Mullin

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  • FDA Approves New Covid Vaccines Amid Summer Surge

    FDA Approves New Covid Vaccines Amid Summer Surge

    Amid a summer surge of Covid-19 infections, the US Food and Drug Administration just approved updated mRNA vaccines that more closely target the currently circulating variants of the coronavirus.

    The updated vaccines, from Moderna and Pfizer/BioNTech, target a variant of Omicron called KP.2, one of the several so-called FLiRT variants that collectively are responsible for the current Covid wave. The new vaccines will likely take a few weeks to reach pharmacies and doctors offices.

    “Given waning immunity of the population from previous exposure to the virus and from prior vaccination, we strongly encourage those who are eligible to consider receiving an updated Covid-19 vaccine,” said Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, in a statement on Thursday.

    The new 2024–25 formula is meant to boost protection against hospitalization and death due to Covid. In 2023, more than 916,300 people were hospitalized due to Covid-19, and more than 75,500 people died from the virus in the US. Vaccination can also protect against long Covid, a chronic condition that lasts at least three months after an infection.

    The US Centers for Disease Control and Prevention recommends the new vaccine for everyone 6 months of age and older, whether or not they have ever previously gotten a Covid-19 vaccine.

    Like the influenza virus, SARS-CoV-2 is constantly changing. And similar to how flu vaccines are updated every year to adapt to the virus’s changing structure, the Covid vaccines are also being updated. Elizabeth Hudson, regional chief of infectious disease at Kaiser Permanente Southern California, says SARS-CoV-2 is changing faster than the flu virus, making it tricky to predict which variants will be dominant by the time the vaccine comes out. “It’s spinning through variants more quickly than what we’re seeing with flu,” she says.

    The FDA green light comes after an advisory committee in June unanimously recommended that manufacturers develop updated Covid vaccines for this fall. Based on the evidence at the time, FDA advisers initially recommended that the new vaccines target a lineage called JN.1, an Omicron offshoot. But the agency updated its guidance, asking vaccine makers to instead target the KP.2 strain, a descendant of the JN.1 variant, to more closely match circulating variants.

    The previous version of the Covid vaccine was greenlit by the FDA on September 11, 2023. That formula targeted the XBB.1.5 variant, the predominant one circulating in the US during the first half of 2023. The virus has mutated substantially since then, and the currently circulating FLiRT variants are thought to be more transmissible and evade the immune system more effectively than prior versions of the virus.

    If you’ve had a Covid-19 infection recently, the CDC says you can consider delaying your vaccine dose by three months.

    “Most of the time, we recommend getting both the Covid and the flu vaccines more toward late September, October, to try to carry people through the winter months,” says Rosha McCoy, a pediatrician and senior director of health care affairs at the Association of American Medical Colleges. “Certainly, if somebody is high-risk or is going to be in a high-risk situation, they may want to get it sooner.”

    Typically, the largest surge of respiratory viruses occurs in the winter. But Covid tends to peak in both winter and summer, and the current summertime surge is likely due to the emergence of new variants and waning protection of the previous vaccine.

    “Any natural immunity or vaccine immunity from 2023 has reached a nadir,” Hudson says. “This is sort of a perfect storm for a more infectious form of Covid.”

    Emily Mullin

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  • This Mpox Outbreak Isn’t Like the Last One

    This Mpox Outbreak Isn’t Like the Last One

    In May 2023, the World Health Organization released a statement declaring the end of mpox—formerly known as monkeypox—as a public health emergency. Just over a year later, the agency has been forced to backtrack, with a far more serious epidemic brewing across much of sub-Saharan Africa.

    Statistics show that more than 15,000 mpox cases and 461 deaths have been reported on the African continent since January, spreading out of countries such as the Democratic Republic of Congo (DRC), where mpox has long been endemic, to 13 other African nations: countries like Rwanda, Kenya, Burundi, and Uganda, where the disease has never previously made an impact.

    In the eyes of scientists like Boghuma Titanji, an associate professor in infectious diseases at Emory University who studies mpox outbreaks, this new, deadlier outbreak represents the consequence of the world’s health watchdogs failing to do enough last time round.

    It was the summer of 2022 when the spread of mpox first set alarm bells ringing. Suddenly a virus which had always been predominantly contained within parts of West and Central Africa was suddenly going worldwide. Between early 2022 and December 2023, there were 92,783 confirmed cases of mpox across 116 countries, leading to 171 deaths.

    Despite these numbers, its perception as a public health threat swiftly faded. “Ninety-five percent of the cases during the 2022 outbreak were among men who have sex with men, reporting exposure through sexual or close contact with another infected person,” says Titanji. “It was an outbreak that was very focused, which allowed vaccinations to be prioritized among that network.”

    Countries in the global north successfully scrambled to suppress the outbreak within their own borders. Meanwhile, Titanji says, ramping up viral surveillance among the African nations who had been battling a steady rise in mpox cases for the past four decades soon slipped down the priority list, allowing a potentially more problematic variant to emerge undetected.

    Mpox exists in two main subtypes, clade 1 and clade 2. Between them, clade 1 is believed to be up to 10 times more deadly, particularly among population groups with weakened or developing immune systems such as children under the age of 5, pregnant women, and immunocompromised people. That’s the viral strain behind this new outbreak, and why infectious disease scientists are so alarmed. (A separate outbreak spreading in South Africa among people living with HIV is thought to be linked to clade 2.)

    “The 2022 global outbreak was clade 2, and mortality was less than 1 percent,” says Jean Nachega, a Congolese infectious disease doctor and an associate professor of medicine at the University of Pittsburgh. “Now we’re talking about a strain which can have up to 10 percent mortality.”

    While the previous outbreak predominantly affected homosexual populations, data indicates that the new strain is also being transmitted far more broadly, perhaps initially through sexual networks and then being passed on to family members. Last month, Nachega and others published a paper in the journal Nature Medicine demonstrating how an outbreak of mpox began in the small mining town of Kamituga in eastern DRC through sex workers before being transmitted to nearby Rwanda, Uganda, and Burundi as the infected individuals returned home to visit their families.

    David Cox

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  • Letters: Remaking U.S. | Back Harris | White wash | Rhetorical game | Free speech

    Letters: Remaking U.S. | Back Harris | White wash | Rhetorical game | Free speech

    Submit your letter to the editor via this form. Read more Letters to the Editor.

    Republican effort to
    remake U.S. terrifies

    If you haven’t seen it, you might want to read the synopsis of Project 2025. Essentially it’s a manifesto for Donald Trump to take over every aspect of American lives, but only to benefit him and his loyalists.

    They plan to remove government employees and agencies. They have no regard for non-Whites, LGBTQ, abortions, women, foreigners and non-Trumpists. There will be no need for Congress or the Supreme Court because all decisions will come from the demagogue himself and his self-designed army.

    Was “1984” a primer for Trump? How much surveillance will there be? How many jails and holding camps will they build for all those in opposition? Will they restore a vigorous execution system?

    They want to end American democracy as we know it. If you’re not concerned about this, then study Germany in 1939.

    Stuart Shicoff
    Martinez

    Back Harris to beat
    Trump at ballot box

    Presidents Biden and Obama are the two best presidents I have experienced in my lifetime. I applaud, admire and respect President Biden so much for sacrificing for our good and not focusing on himself. He and his team, including Vice President Harris, pulled us out of an extremely dark time.

    In November, we have two choices: democracy vs. dictatorship. It’s time to finally put aside gender and race and focus on the issues that matter to us all.

    If you haven’t yet read Project 2025, please read it. There’s a summary on Wikipedia so you don’t have to read 900 pages. It’s Donald Trump’s blueprint for a dictatorship and police state and covers all of the issues that are important to Americans. Kamala Harris is the most qualified and experienced individual who can beat Trump at the ballot box. It’s a no-brainer.

    Ramona Krausnick
    Dublin

    Democrats’ whitewashing
    of the coercion of Biden

    According to Martha Raddatz, ABC News, senior White House sources recently said that Joe Biden was lashing out at any suggestion of dropping out.

    But with a political tidal wave of Democratic elites knocking over his determination to continue running on the basis that he could not win, and after the final assault by Nancy Pelosi and Chuck Schumer, Biden was finally forced to resign from the race. A New York Times opinion piece calls this “a noble patriotic move; a selfless American giving up power willingly for the good of the country.” Coercion is more like it.

    This narrative is a Democratic Party line whitewashing reality which we will see repeated ad nauseum.

    Stephan Pinto
    Walnut Creek

    GOP’s dangerous
    rhetorical game still on

    Re: “Left is stoking outrage and anger” (Page A9, July 21).

    Shaun McCutcheon, chairman of the Coolidge Reagan Foundation, advocates for the shooting of protesters: “Rioters don’t riot where they will be shot.” He says that leftist leaders who were soft on protesters were the causes of the Donald Trump assassination attempt.

    This scary kind of thinking confirms the wisdom of voting for the best Democratic candidate in November.

    Steve Turnwall
    Lafayette

    Upcoming federal case
    pivots on free speech

    The case against the Uhuru 3 — Omali Yeshitela, Penny Hess, and Jesse Nevel — is a troubling challenge of our most important constitutional right.

    Letters To The Editor

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  • US Government Awards Moderna $176 Million for mRNA Bird Flu Vaccine

    US Government Awards Moderna $176 Million for mRNA Bird Flu Vaccine

    The US government will pay Moderna $176 million to develop an mRNA vaccine against a pandemic influenza—an award given as the highly pathogenic bird flu virus H5N1 continues to spread widely among US dairy cattle.

    The funding flows through BARDA, the Biomedical Advanced Research and Development Authority, as part of a new Rapid Response Partnership Vehicle (RRPV) Consortium. The program is intended to set up partnerships with industry to help the country better prepare for pandemic threats and develop medical countermeasures, the Department of Health and Human Services said in a press announcement Tuesday.

    In its own announcement on Tuesday, Moderna noted that it began a Phase 1/2 trial of a pandemic influenza virus vaccine last year, which included versions targeting H5 and H7 varieties of bird flu viruses. The company said it expects to release the results of that trial this year and that those results will direct the design of a Phase 3 trial, anticipated to begin in 2025.

    The funding deal will support late-stage development of a “prepandemic vaccine against H5 influenza virus,” Moderna said. But the deal also includes options for additional vaccine development in case other public health threats arise.

    “mRNA vaccine technology offers advantages in efficacy, speed of development, and production scalability and reliability in addressing infectious disease outbreaks, as demonstrated during the Covid-19 pandemic,” Moderna CEO Stéphane Bancel said in the announcement. “We are pleased to continue our collaboration with BARDA to expedite our development efforts for mRNA-based pandemic influenza vaccines and support the global public health community in preparedness against potential outbreaks.”

    US health officials have said previously that they were in talks with Moderna and Pfizer about the development of a pandemic bird flu vaccine. The future vaccine will be in addition to standard protein-based bird flu vaccines that are already developed. In recent weeks, the health department has said it is working to manufacture 4.8 million vials of H5 influenza vaccine in the coming months. The plans come three months into the H5N1 dairy outbreak, which is very far from the initial hopes of containment.

    Botched Response

    The US is badly fumbling its response to the unprecedented outbreak, drawing criticism from US-based and international experts alike. Genetic analyses suggest that the virus has been spreading among the country’s dairy cattle since late last year. But it wasn’t until months later, on March 25, that the US Department of Agriculture confirmed the first four infected herds in two states (Texas and Kansas). Since then, the outbreak has spread to around 140 herds in 12 states—at least.

    Some farms are refusing to test, and experts expect that there is a significant number of undocumented herd infections, particularly given the widespread detection of inactivated H5N1 in the commercial milk supply. Furthermore, of the 140 herds with documented infections, federal officials do not know how many are still actively infected rather than recovered. It is unclear whether infected cows can become reinfected, and if so, how quickly after an infection.

    While the risk to the general public is considered to be low currently, farm workers are at higher risk of contracting the infection. To date, there have been three confirmed infections among dairy farm workers—one in Texas and two in Michigan, which has had a uniquely robust response to the outbreak. Still, with hundreds to thousands of farm workers at risk of contracting the virus, only 53 people in the country to date have been tested for H5 influenza.

    Beth Mole, Ars Technica

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  • Supreme Court Rejects Covid-Related Appeals by Kennedy’s Children’s Health Defense

    Supreme Court Rejects Covid-Related Appeals by Kennedy’s Children’s Health Defense

    On Monday, the Supreme Court declined to hear two Covid-related appeals brought by Children’s Health Defense, the anti-vaccine group founded by independent presidential candidate Robert F. Kennedy Jr. This decision leaves lower court rulings against the group in place.

    One case challenged the FDA’s emergency authorization of Covid-19 vaccines in December 2020, claiming the vaccines were “ineffective and lacked proper vetting.” The 5th U.S. Circuit Court of Appeals found that Kennedy’s group did not have legal standing to sue. The other case was against Rutgers University over its Covid-19 vaccine mandate. The 3rd U.S. Circuit Court of Appeals concluded that the plaintiffs “have not stated any plausible claim for relief.”

    Kennedy, who left the group in April 2023 to run for president, is listed as a lawyer on the Rutgers filing at the Supreme Court. Despite his leave of absence, he spoke at a Children’s Health Defense conference in November, downplaying his anti-vaccine activity on the campaign trail.

    In a related matter, the court also turned away a challenge to Connecticut’s decision to repeal a religious exemption for school vaccinations.


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  • InDevR and Sino Biological Team Up to Deliver Multiplexed Analytical Solutions for mRNA Vaccine and Cell & Gene Therapy

    InDevR and Sino Biological Team Up to Deliver Multiplexed Analytical Solutions for mRNA Vaccine and Cell & Gene Therapy

    Partnership addresses biopharmaceutical industry’s urgent need for improved in-process and QC testing tools for these rapidly evolving application fields

    InDevR, Inc., a leader in analytical solutions for vaccine in-process and quality control testing, and Sino Biological, Inc., a biotechnology company listed on the Shenzhen stock exchange subsidiary ChiNext (SZSE: 301047) specializing in biological research reagents and related technical contract research services, today announced a new partnership to speed development of multiplexed assays for a broad range of vaccine, mRNA therapies and cell and gene therapy applications.  

    Through this partnership, Sino Biological’s catalog of high-quality antibodies, antigens, and other reagents are available for use on InDevR’s VaxArray Platform. Biopharmaceutical companies worldwide currently employ the VaxArray Platform’s multiplex assay capabilities in their vaccine testing to simplify, standardize and speed novel vaccine development, optimization of existing formulations and production scale-up. The two companies aim to accelerate the development and deployment of multiparametric analytical tools to aid researchers in driving advancements in mRNA, vaccine development and the rapidly evolving field of cell and gene therapy.

    Since 2003, InDevR’s core focus has been to deliver innovative analytical tools for the vaccine industry. “Moving forward, our goal is to leverage that expertise to address the urgent need for improved analytical tools for cell and gene therapies and mRNA vaccine testing. Our partnership with Sino Biological, with their extraordinary breadth and depth of offerings and commitment to quality, will drive new product development and empower our customers to design their own multiplex assays with ease,” said Dr. Kathy Rowlen, CEO of InDevR.

    Experts in recombinant protein production and antibody development, Sino Biological is equally enthusiastic about the collaboration. “We are thrilled to partner with InDevR to enhance the capabilities of their VaxArray Platform,” Sino Biological Chief Business Officer Dr. Rob Burgess stated. “Our comprehensive range of quality reagents, combined with InDevR’s cutting-edge analytical technology, promises to deliver superior solutions for in-process and quality control testing in the biopharmaceutical industry.”

    About InDevR

    InDevR is a leader in innovative solutions for in-process, QC, and release testing of vaccines. Committed to enhancing the speed and accuracy of vaccine and other biological product characterization, InDevR’s products and services are trusted by leading pharmaceutical companies and research institutions around the globe.

    About Sino Biological

    Sino Biological is an international reagent supplier and contract research service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological’s products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research. In addition, Sino Biological offers contract research production services for the custom development of full-length, bioactive proteins and high-affinity antibodies, along with other services. To learn more about Sino Biological, visit www.sinobiological.com, follow the company on LinkedIn or @SinoInc on Twitter.

    Forward-Looking Statements

    Certain statements in this document are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act. These statements are based on InDevR and Sino Biological management’s current expectations and are subject to uncertainty and changes in circumstances. Actual results may differ materially from those included in these statements due to a variety of factors, over which neither InDevR nor Sino Biological has control. InDevR and Sino Biological assume no obligation to update these forward-looking statements and do not intend to do so.

    For media inquiries or partnership opportunities, please contact:

    InDevR, Inc.

    Craig Hoechstetter
    Vice President, Sales & Marketing
    csh@indevr.com

    Sino Biological, Inc.

    gmo@sinobiological.cn

    www.sinobiological.com

    Source: InDevR, Inc.

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  • HPV Vaccines Prevent Cancer in Men as Well as Women

    HPV Vaccines Prevent Cancer in Men as Well as Women

    New research suggests the HPV vaccine is preventing cancer in men, as well as in women, but fewer boys than girls are getting the shots in the United States.

    The HPV vaccine was developed to prevent cervical cancer in women and experts give it credit, along with screening, for lowering cervical cancer rates. Evidence that the shots are preventing HPV-related cancers in men has been slower to emerge, but the new research suggests vaccinated men have fewer cancers of the mouth and throat compared to those who didn’t get the shots. These cancers are more than twice as common in men than in women.

    For the study, researchers compared 3.4 million people of similar ages — half vaccinated versus half unvaccinated — in a large health care dataset.

    As expected, vaccinated women had a lower risk of developing cervical cancer within at least five years of getting the shots. For men, there were benefits too. Vaccinated men had a lower risk of developing any HPV-related cancer, such as cancers of the anus, penis and mouth and throat.

    These cancers take years to develop so the numbers were low: There were 57 HPV-related cancers among the unvaccinated men — mostly head and neck cancers — compared to 26 among the men who had the HPV vaccine.

    “We think the maximum benefit from the vaccine will actually happen in the next two or three decades,” said study co-author Dr. Joseph Curry, a head and neck surgeon at the Sidney Kimmel Cancer Center in Philadelphia. “What we’re showing here is an early wave of effect.”

    Results of the study and a second were released Thursday by the American Society of Clinical Oncology and will be discussed next month at its annual meeting in Chicago. The second study shows vaccination rates rising but males lag behind females in getting the HPV shots.

    HPV, or human papillomavirus, is very common and is spread through sex. Most HPV infections cause no symptoms and clear up without treatment. Others develop into cancer, about 37,000 cases a year, according to the Centers for Disease Control and Prevention.

    In the U.S., the HPV vaccine has been recommended since 2006 for girls at age 11 or 12, and since 2011 for boys the same age. Catch-up shots are recommended for anyone through age 26 who hasn’t been vaccinated.

    In the second study, researchers looked at self- and parent-reported HPV vaccination rates in preteens and young adults in a large government survey. From 2011 to 2020, vaccination rates rose from 38% to 49% among females, and among males from 8% to 36%.

    “HPV vaccine uptake among young males increased by more than fourfold over the last decade, though vaccination rates among young males still fall behind females,” said study co-author Dr. Danh Nguyen at the University of Texas Southwestern Medical Center in Dallas.

    Parents of boys, as well as girls, should know that HPV vaccines lower cancer risk, said Jasmin Tiro of the University of Chicago Medicine Comprehensive Cancer Center who was not involved in the research. And young men who haven’t been vaccinated can still get the shots.

    “It’s really important that teenagers get exposed to the vaccine before they’re exposed to the virus,” she said.

    ___

    The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

    CARLA K. JOHNSON / AP

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  • 4 ways vaccine skeptics mislead you on measles and more

    4 ways vaccine skeptics mislead you on measles and more

    Measles is on the rise in the United States. So far this year, the number of cases is about 17 times what it was, on average, during the same period in each of the four years before, according to the Centers for Disease Control and Prevention. Half of the people infected — mainly children — have been hospitalized.

    It’s going to get worse, largely because a growing number of parents are deciding not to get their children vaccinated against measles as well as diseases like polio and pertussis. Unvaccinated people, or those whose immunization status is unknown, account for 80% of the measles cases this year. Many parents have been influenced by a flood of misinformation spouted by politicians, podcast hosts, and influential figures on television and social media. These personalities repeat decades-old notions that erode confidence in the established science backing routine childhood vaccines. KFF Health News examined the rhetoric and explains why it’s misguided

    The no-big-deal trope

    A common distortion is that vaccines aren’t necessary because the diseases they prevent are not very dangerous, or too rare to be of concern. Cynics accuse public health officials and the media of fear-mongering about measles even as 19 states report cases. 

    For example, an article posted on the website of the National Vaccine Information Center — a regular source of vaccine misinformation — argued that a resurgence in concern about the disease “is ‘sky is falling’ hype.” It went on to call measles, mumps, chicken pox and influenza “politically incorrect to get.”

    Measles kills roughly 2 of every 1,000 children infected, according to the CDC. If that seems like a bearable risk, it’s worth pointing out that a far larger portion of children with measles will require hospitalization for pneumonia and other serious complications. For every 10 measles cases, one child with the disease develops an ear infection that can lead to permanent hearing loss. Another strange effect is that the measles virus can destroy a person’s existing immunity, meaning they’ll have a harder time recovering from influenza and other common ailments.

    Measles vaccines have averted the deaths of about 94 million people, mainly children, over the past 50 years, according to an April analysis led by the World Health Organization. Together with immunizations against polio and other diseases, vaccines have saved an estimated 154 million lives globally.

    Some skeptics argue that vaccine-preventable diseases are no longer a threat because they’ve become relatively rare in the U.S. (True — due to vaccination.) This reasoning led Florida’s surgeon general, Joseph Ladapo, to tell parents that they could send their unvaccinated children to school amid a measles outbreak in February. “You look at the headlines and you’d think the sky was falling,” Ladapo said on a News Nation newscast. “There’s a lot of immunity.”

    As this lax attitude persuades parents to decline vaccination, the protective group immunity will drop, and outbreaks will grow larger and faster. A rapid measles outbreak hit an undervaccinated population in Samoa in 2019, killing 83 people within four months. A chronic lack of measles vaccination in the Democratic Republic of the Congo led to more than 5,600 people dying from the disease in massive outbreaks last year.

    The “you never know” trope

    Since the earliest days of vaccines, a contingent of the public has considered them bad because they’re unnatural, as compared with nature’s bounty of infections and plagues. “Bad” has been redefined over the decades. In the 1800s, vaccine skeptics claimed that smallpox vaccines caused people to sprout horns and behave like beasts. More recently, they blame vaccines for ailments ranging from attention-deficit/hyperactivity disorder to autism to immune system disruption. Studies don’t back the assertions. However, skeptics argue that their claims remain valid because vaccines haven’t been adequately tested.

    In fact, vaccines are among the most studied medical interventions. Over the past century, massive studies and clinical trials have tested vaccines during their development and after their widespread use. More than 12,000 people took part in clinical trials of the most recent vaccine approved to prevent measles, mumps and rubella. Such large numbers allow researchers to detect rare risks, which are a major concern because vaccines are given to millions of healthy people.

    To assess long-term risks, researchers sift through reams of data for signals of harm. For example, a Danish group analyzed a database of more than 657,000 children and found that those who had been vaccinated against measles as babies were no more likely to later be diagnosed with autism than those who were not vaccinated. In another study, researchers analyzed records from 805,000 children born from 1990 through 2001 and found no evidence to back a concern that multiple vaccinations might impair children’s immune systems.

    Nonetheless, people who push vaccine misinformation, like candidate Robert F. Kennedy Jr., dismiss massive, scientifically vetted studies. For example, Kennedy argues that clinical trials of new vaccines are unreliable because vaccinated kids aren’t compared with a placebo group that gets saline solution or another substance with no effect. Instead, many modern trials compare updated vaccines with older ones. That’s because it’s unethical to endanger children by giving them a sham vaccine when the protective effect of immunization is known. In a 1950s clinical trial of polio vaccines, 16 children in the placebo group died of polio and 34 were paralyzed, said Paul Offit, director of the Vaccine Education Center at Children’s Hospital of Philadelphia and author of a book on the first polio vaccine.

    The too-much-too-soon trope

    Several bestselling vaccine books on Amazon promote the risky idea that parents should skip or delay their children’s vaccines. “All vaccines on the CDC’s schedule may not be right for all children at all times,” writes Paul Thomas in his bestselling book “The Vaccine-Friendly Plan.” He backs up this conviction by saying that children who have followed “my protocol are among the healthiest in the world.”

    Since the book was published, Thomas’ medical license was temporarily suspended in Oregon and Washington. The Oregon Medical Board documented how Thomas persuaded parents to skip vaccines recommended by the CDC, and reported that he “reduced to tears” a mother who disagreed.  Several children in his care came down with pertussis and rotavirus, diseases easily prevented by vaccines, wrote the board. Thomas recommended fish oil supplements and homeopathy to an unvaccinated child with a deep scalp laceration, rather than an emergency tetanus vaccine. The boy developed severe tetanus, landing in the hospital for nearly two months, where he required intubation, a tracheotomy and a feeding tube to survive.

    The vaccination schedule recommended by the CDC has been tailored to protect children at their most vulnerable points in life and minimize side effects. The combination measles, mumps, and rubella vaccine isn’t given for the first year of a baby’s life because antibodies temporarily passed on from their mother can interfere with the immune response. And because some babies don’t generate a strong response to that first dose, the CDC recommends a second one around the time a child enters kindergarten because measles and other viruses spread rapidly in group settings.

    Delaying MMR doses much longer may be unwise because data suggests that children vaccinated at 10 or older have a higher chance of adverse reactions, such as a seizure or fatigue.

    Around a dozen other vaccines have discrete timelines, with overlapping windows for the best response. Studies have shown that MMR vaccines may be given safely and effectively in combination with other vaccines.

    “They don’t want you to know” trope

    Kennedy compares the Florida surgeon general to Galileo in the introduction to Ladapo’s new book on transcending fear in public health. Just as the Roman Catholic inquisition punished the renowned astronomer for promoting theories about the universe, Kennedy suggests that scientific institutions oppress dissenting voices on vaccines for nefarious reasons.

    “The persecution of scientists and doctors who dare to challenge contemporary orthodoxies is not a new phenomenon,” Kennedy writes. His running mate, lawyer Nicole Shanahan, has campaigned on the idea that conversations about vaccine harms are censored and the CDC and other federal agencies hide data due to corporate influence. 

    Claims like “they don’t want you to know” aren’t new among the anti-vaccine set, even though the movement has long had an outsize voice. The most listened-to podcast in the U.S., “The Joe Rogan Experience,” regularly features guests who cast doubt on scientific consensus. Last year on the show, Kennedy repeated the debunked claim that vaccines cause autism.

    Far from ignoring that concern, epidemiologists have taken it seriously. They have conducted more than a dozen studies searching for a link between vaccines and autism, and repeatedly found none. “We have conclusively disproven the theory that vaccines are connected to autism,” said Gideon Meyerowitz-Katz, an epidemiologist at the University of Wollongong in Australia. “So, the public health establishment tends to shut those conversations down quickly.”

    Federal agencies are transparent about seizures, arm pain and other reactions that vaccines can cause. And the government has a program to compensate individuals whose injuries are scientifically determined to result from them. Around 1 to 3.5 out of every million doses of the measles, mumps and rubella vaccine can cause a life-threatening allergic reaction; a person’s lifetime risk of death by lightning is estimated to be as much as four times as high.

    “The most convincing thing I can say is that my daughter has all her vaccines and that every pediatrician and public health person I know has vaccinated their kids,” Meyerowitz-Katz said. “No one would do that if they thought there were serious risks.”

    KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF — the independent source for health policy research, polling and journalism.

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  • There’s New Hope for an HIV Vaccine

    There’s New Hope for an HIV Vaccine

    Since it was first identified in 1983, HIV has infected more than 85 million people and caused some 40 million deaths worldwide.

    While medication known as pre-exposure prophylaxis, or PrEP, can significantly reduce the risk of getting HIV, it has to be taken every day to be effective. A vaccine to provide lasting protection has eluded researchers for decades. Now, there may finally be a viable strategy for making one.

    An experimental vaccine developed at Duke University triggered an elusive type of broadly neutralizing antibody in a small group of people enrolled in a 2019 clinical trial. The findings were published today in the scientific journal Cell.

    “This is one of the most pivotal studies in the HIV vaccine field to date,” says Glenda Gray, an HIV expert and the president and CEO of the South African Medical Research Council, who was not involved in the study.

    A few years ago, a team from Scripps Research and the International AIDS Vaccine Initiative (IAVI) showed that it was possible to stimulate the precursor cells needed to make these rare antibodies in people. The Duke study goes a step further to generate these antibodies, albeit at low levels.

    “This is a scientific feat and gives the field great hope that one can construct an HIV vaccine regimen that directs the immune response along a path that is required for protection,” Gray says.

    Vaccines work by training the immune system to recognize a virus or other pathogen. They introduce something that looks like the virus—a piece of it, for example, or a weakened version of it—and by doing so, spur the body’s B cells into producing protective antibodies against it. Those antibodies stick around so that when a person later encounters the real virus, the immune system remembers and is poised to attack.

    While researchers were able to produce Covid-19 vaccines in a matter of months, creating a vaccine against HIV has proven much more challenging. The problem is the unique nature of the virus. HIV mutates rapidly, meaning it can quickly outmaneuver immune defenses. It also integrates into the human genome within a few days of exposure, hiding out from the immune system.

    “Parts of the virus look like our own cells, and we don’t like to make antibodies against our own selves,” says Barton Haynes, director of the Duke Human Vaccine Institute and one of the authors on the paper.

    The particular antibodies that researchers are interested in are known as broadly neutralizing antibodies, which can recognize and block different versions of the virus. Because of HIV’s shape-shifting nature, there are two main types of HIV and each has several strains. An effective vaccine will need to target many of them.

    Some HIV-infected individuals generate broadly neutralizing antibodies, although it often takes years of living with HIV to do so, Haynes says. Even then, people don’t make enough of them to fight off the virus. These special antibodies are made by unusual B cells that are loaded with mutations they’ve acquired over time in reaction to the virus changing inside the body. “These are weird antibodies,” Haynes says. “The body doesn’t make them easily.”

    Emily Mullin

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  • RFK Jr. secures ballot access in Michigan as potential spoiler

    RFK Jr. secures ballot access in Michigan as potential spoiler

    click to enlarge

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    Robert F. Kennedy will appear on Michigan’s presidential ballot.

    Robert F. Kennedy Jr., a potential spoiler candidate who has spread misinformation about vaccines and COVID-19, will appear on Michigan’s presidential ballot.

    Kennedy, 70, gained access to the ballot after the Natural Law Party nominated him to be the party’s candidate.

    Michigan is the eighth state where Kennedy, the nephew of slain President John F. Kennedy, secured ballot access.

    The Michigan Secretary of State’s office confirmed to Metro Times that Kennedy qualified for the ballot.

    Kennedy’s running mate is Nicole Shanahan, a 38-year-old Silicon Valley attorney and entrepreneur who falsely suggested last month that “pharmaceutical medicines” such as vaccines and prescription drugs are linked to the surge in autism in children.

    “He’s the most qualified candidate in the modern-day history of America,” Natural Law Party Chairman Doug Dern said in a news release. “We welcome Mr. Kennedy and Ms. Shanahan to the party.”

    Kennedy is working to win over disgruntled Americans who are tired of the two-party system. He has drawn support from the anti-establishment crowd, and his appeal spans across party lines.

    In a swing state like Michigan, where Donald Trump narrowly won in 2016 and Joe Biden triumphed in 2020, Kennedy’s spot on the ballot could impact the outcome.

    Kennedy was polling at 13% in Michigan, according to a survey conducted earlier this month by Marketing Resource Group. The same poll found Trump received 37%, and Biden got 34%.

    According to the survey, Kennedy had more support among self-described independents than Biden in Michigan. That poll showed Trump got 33%, Kennedy had 22%, and Biden received 21%.

    Whether Kennedy will draw more votes from Biden or Trump is the subject of much debate and speculation. Kennedy is known for his famous name and environmental work, and he began his run for president as a Democrat, which could take votes from Biden.

    In March, Trump called Kennedy’s bid “great for MAGA.”

    But Kennedy’s anti-vaccine campaign and tendency to spread conspiracy theories could appeal to Trump voters. Kennedy and his nonprofit have been removed from social media sites for spreading misinformation.

    In September 2023, Kennedy resurrected a conspiracy theory about 9/11 and refused to say that al-Qaeda was behind the attacks on New York and Washington, D.C.

    He also criticized the U.S. for funding Ukraine.

    His own family prefers Biden. At a campaign rally in Philadelphia on Thursday, about a dozen Kennedys gathered to support the current president. They included Kennedy’s siblings Joseph, Kerry, Rory, Kathleen, Maxwell, and Christopher.

    “He has us thriving again, believing again, behaving like good neighbors again,” Kerry Kennedy said of Biden as five siblings looked on from the stage, The New York Times reports. “Nearly every single grandchild of Joe and Rose Kennedy supports Joe Biden. That’s right, the Kennedy family endorses Joe Biden for president.”

    Kennedy will be celebrating his appearance on the Michigan ballot by hosting “A Night of Laughter” comedy show at the Royal Oak Theatre. Other performers include Rob Schneider, Dave Landau, Heather Jay, Mike Binder, Tre Stewart, and Erica Rhodes.

    “Kennedy is good for Michigan,” Bill Costantino, western Michigan regional coordinator for the Natural Law Party. “As an environmental champion for more than 40 years, Kennedy will work to restore our Great Lakes region, which holds 20% of the world’s freshwater. He will ensure a thriving fishing economy and ecosystem for commercial fishermen and individual anglers.”

    Steve Neavling

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  • US measles cases are up in 2024. What’s driving the increase?

    US measles cases are up in 2024. What’s driving the increase?

    By DEVI SHASTRI and MIKE STOBBE (Associated Press)

    Measles outbreaks in the U.S. and abroad are raising health experts’ concern about the preventable, once-common childhood virus.

    One of the world’s most contagious diseases, measles can lead to potentially serious complications. The best defense, according to experts? Get vaccinated.

    Here’s what to know about the year — so far — in measles.

    How many measles cases has the U.S. seen this year?

    Nationwide, measles cases already are nearly double the total for all of last year.

    The U.S. Centers of Disease Control and Prevention documented 113 cases as of April 5. There have been seven outbreaks and most of U.S. cases — 73% — are linked to those flare-ups.

    Still, the count is lower than some recent years: 2014 saw 667 cases and 2019 had 1,274.

    Why is this a big deal?

    The 2019 measles epidemic was the worst in almost three decades, and threatened the United States’ status as a country that has eliminated measles by stopping the continual spread of the measles virus.

    The CDC on Thursday released a report on recent measles case trends, noting that cases in the first three months of this year were 17 times higher than the average number seen in the first three months of the previous three years.

    While health officials seem to be doing a good job detecting and responding to outbreaks, “the rapid increase in the number of reported measles cases during the first quarter of 2024 represents a renewed threat to elimination,” the report’s authors said.

    Where is measles coming from?

    The disease is still common in many parts of the world, and measles reaches the U.S. through unvaccinated travelers.

    According to Thursday’s report, most of the recent importations involved unvaccinated Americans who got infected in the Middle East and Africa and brought measles back to the U.S.

    Where were this year’s U.S. measles outbreaks?

    Health officials confirmed measles cases in 17 states so far this year, including cases in New York City, Philadelphia and Chicago.

    More than half of this year’s cases come from the Chicago outbreak, where 61 people have contracted the virus as of Thursday, largely among people who lived in a migrant shelter.

    The city health department said Thursday that cases are on the decline after health officials administered 14,000 vaccines in just over a month.

    How does measles spread?

    Measles is highly contagious. It spreads when people who have it breathe, cough or sneeze and through contaminated surfaces. It also can linger in the air for two hours.

    Up to 9 out of 10 people who are susceptible will get the virus if exposed, according to the CDC.

    Measles used to be common among kids. How bad was it?

    Before a vaccine became available in 1963, there were some 3 million to 4 million cases per year, which meant nearly all American kids had it sometime during childhood, according to the CDC. Most recovered.

    But measles can be much more than an uncomfortable rash, said Susan Hassig, an infectious disease researcher at Tulane University.

    “I think that people need to remember that this is a preventable disease,” Hassig said. “It is a potentially dangerous disease for their children.”

    In the decade before the vaccine was available, 48,000 people were hospitalized per year. About 1,000 people developed dangerous brain inflammation from measles each year, and 400 to 500 died, according to the CDC.

    Is the measles vaccine safe? Where do vaccination rates stand?

    The measles, mumps and rubella (MMR) vaccine is safe and effective. It is a routine and recommended childhood vaccine that is split into two doses.

    Research shows it takes a very high vaccination rate to prevent measles from spreading: 95% of the population should have immunity against the virus.

    During the COVID-19 pandemic, national vaccination rates for kindergartners fell to 93% and remain there. Many pockets of the country have far lower rates than that. The drop is driven in part by record numbers of kids getting waivers.

    ___

    The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

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    The Associated Press

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  • There Are Already More Measles Cases in the US This Year Than All of 2023

    There Are Already More Measles Cases in the US This Year Than All of 2023

    The Centers for Disease Control and Prevention and the American Medical Association sent out separate but similar pleas on Monday for unvaccinated Americans to get vaccinated against the extremely contagious measles virus as vaccination rates have slipped, cases are rising globally and nationally, and the spring-break travel period is beginning.

    In the first 12 weeks of 2024, US measles cases have already matched and likely exceeded the case total for all of 2023. According to the CDC, there were 58 measles cases reported from 17 states as of March 14. But media tallies indicate there have been more cases since then, with at least 60 cases now in total, according to CBS News. In 2023, there were 58 cases in 20 states.

    “As evident from the confirmed measles cases reported in 17 states so far this year, when individuals are not immunized as a matter of personal preference or misinformation they put themselves and others at risk of disease—including children too young to be vaccinated, cancer patients, and other immunocompromised people,” AMA president Jesse Ehrenfeld said Monday in a statement urging vaccination.

    The latest data indicates that vaccination rates among US kindergarteners have slipped to 93 percent nationally, below the 95 percent target to prevent the spread of the disease. And vaccine exemptions for non-medical reasons have reached an all-time high.

    The CDC released a health advisory on Monday also urging measles vaccination. The CDC drove home the point that unvaccinated Americans are largely responsible for importing the virus, and pockets of unvaccinated children in local communities spread it once it’s here. The 58 measles infections that have been reported to the agency so far include cases from seven outbreaks in seven states. Most of the cases are in vaccine-eligible children aged 12 months and older who are unvaccinated. Of the 58 cases, 54 (93 percent) are linked to international travel, and most measles importations are by unvaccinated US residents who travel abroad and bring measles home with them, the CDC flagged.

    The situation is likely to worsen as Americans begin spring travel, the CDC suggested. “Many countries, including travel destinations such as Austria, the Philippines, Romania, and the United Kingdom, are experiencing measles outbreaks,” the CDC said. “To prevent measles infection and reduce the risk of community transmission from importation, all US residents traveling internationally, regardless of destination, should be current on their MMR [measles-mumps-rubella] vaccinations.” The agency added in a recommendation to parents that “even if not traveling, ensure that children receive all recommended doses of MMR vaccine. Two doses of MMR vaccine provide better protection (97 percent) against measles than one dose (93 percent). Getting MMR vaccine is much safer than getting measles, mumps, or rubella.”

    For Americans who are already vaccinated and for communities with high vaccination coverage, the risk is low, the CDC noted. “However, pockets of low coverage leave some communities at higher risk for outbreaks.” This, in turn, threatens wider, continuous spread that could overturn the country’s status of having eliminated measles, which was declared in 2000. The US was close to losing its elimination status in 2019 when outbreaks among unvaccinated children drove 1,247 cases across 31 states. Vaccination rates have fallen since then.

    “The reduction in measles vaccination threatens to erase many years of progress as this previously eliminated vaccine-preventable disease returns,” the AMA’s Ehrenfeld warned.

    As Ars Technica has reported previously, measles is among the most contagious viruses known and can linger in airspace for up to two hours. Up to 90 percent of unvaccinated people exposed will contract it. Symptoms can include high fever, runny nose, red and watery eyes, and a cough, as well as the hallmark rash. About one in five unvaccinated people with measles are hospitalized, while one in 20 infected children develop pneumonia, and up to three in 1,000 children die of the infection. Brain swelling (encephalitis) can occur in one in 1,000 children, which can lead to hearing loss and intellectual disabilities. The virus can also destroy immune responses to previous infections—a phenomenon known as “immune amnesia”—which can leave children vulnerable to various other infections for years afterward.

    This story originally appeared on Ars Technica.

    Beth Mole, Ars Technica

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  • The Return of Measles

    The Return of Measles

    Measles seems poised to make a comeback in America. Two adults and two children staying at a migrant shelter in Chicago have gotten sick with the disease. A sick kid in Sacramento, California, may have exposed hundreds of people to the virus at the hospital. Three other people were diagnosed in Michigan, along with seven from the same elementary school in Florida. As of Thursday, 17 states have reported cases to the CDC since the start of the year. (For comparison, that total was 19, plus the District of Columbia, for all of 2023, and just 6 for 2022.) “We’ve got this pile of firewood,” Matthew Ferrari, the director of the Center for Infectious Disease Dynamics at Penn State, told me, “and the more outbreaks that keep happening, the more matches we’re throwing at it.”

    Who’s holding the matchbook? There’s an easy answer to who’s at fault. One of the nation’s political parties, and not the other, turned against vaccines to some extent during the pandemic, leading to voter disparities in death rates. One party, and not the other, has a presumptive presidential candidate who threatens to punish any school that infringes on parental rights by requiring immunizations. And one party, but not the other, appointed a vaccine-skeptical surgeon general in Florida who recently sidestepped standard public-health advice in the middle of an outbreak. The message from Republicans, as The Washington Post’s Alexandra Petri joked in a recent column, can sound like this: “We want measles in the schools and books out of them!”

    But the politics of vaccination, however grotesque it may be in 2024, obscures what’s really going on. It’s true that vaccine attitudes have become more polarized. Conservative parents in particular may be opting out of school vaccine requirements in higher numbers than they were before. In the blood-red state of Idaho, for example, more than 12 percent of kindergartners received exemptions from the rules for the 2022–23 school year, a staggering rate of refusal that is up by half from where it was just a few years ago. Politicized recalcitrance is unfortunate, to say the least, and it can be deadly. Even so, America’s political divides are simply not the cause of any recent measles outbreak. The virus has returned amid a swirl of global health inequities. Any foothold that it finds in the U.S. will be where hyperlocal social norms, not culture-war debates, are causing gaps in vaccine access and acceptance. The more this fact is overlooked, the more we’re all at risk.

    Consider where the latest measles cases have been sprouting up: By and large, the recent outbreaks have been a blue-state phenomenon. (Idaho has so far been untouched; the same is true for Utah, with the nation’s third-highest school-vaccine-exemption rate.) Zoom into the county level, and you’ll find that the pattern is repeated: Measles isn’t picking on Republican communities; if anything, it seems to be avoiding them. The recent outbreak in Florida unfolded not in a conservative area such as Sarasota, where vaccination coverage has been lagging, but rather in Biden-friendly Broward County, at a school where 97 percent of the students have received at least one MMR shot. Similarly, the recent cases in Michigan turned up not in any of the state’s MAGA-voting, vaccine-forgoing areas but among the diverse and relatively left-wing populations in and around Ann Arbor and Detroit.

    Stepping back to look at the country as a whole, one can’t even find a strong connection—or, really, any consistent link at all—between U.S. measles outbreaks, year to year, and U.S. children’s vaccination rates. Sure, the past three years for which we have student-immunization data might seem to show a pattern: Starting in the fall of 2020, the average rate of MMR coverage for incoming kindergarteners did drop, if only by a little bit, from 93.9 to 93.1 percent; at the same time, the annual number of reported measles cases went up almost tenfold, from 13 to 121. But stretch that window back one more year, and the relationship appears to be reversed. In 2019, America was doing great in terms of measles vaccination—across the country, 95.2 percent of kindergartners were getting immunized, according to the CDC—and yet, in spite of this fantastic progress, measles cases were exploding. More than 1,200 Americans got sick with the disease that year, as measles took its greatest toll in a generation.

    It’s not that our high measles-vaccination coverage didn’t matter then or that our slightly lower coverage doesn’t matter now. Vaccination rates should be higher; this is always true. In the face of such a contagious disease, 95 percent would be good; 99 percent much better. When fewer people are protected, more people can get sick. In Matthew Ferrari’s terms, a dropping immunization rate means the piles of firewood are getting bigger. If and when the flames do ignite, they could end up reaching farther, and burning longer, than they would have just a year or two ago. In the midst of any outbreak large enough, where thousands are affected, children will die.

    Despite America’s fevered national conversation about vaccines, however, rates of uptake simply haven’t changed that much. Even with the recent divot in our national vaccine rates, the country remains in broad agreement on the value of immunity: 93 percent of America’s kindergartners are getting measles shots, a rate that has barely budged for decades. The sheer resilience of this norm should not be downplayed or ignored or, even worse, reimagined as a state of grace from which we’ve fallen. Our protection remains strong. In Florida, the surgeon general’s lackadaisical response to the crisis at the Broward County elementary school did not produce a single extra case of the disease, in spite of grim predictions to the contrary, almost certainly thanks to how many kids are already vaccinated.

    At the same time, however, measles has been thriving overseas. Its reemergence in America is not a function of the nation’s political divides, but of the disease’s global prevalence. Europe had almost 60,000 cases last year, up from about 900 in 2022. The World Health Organization reports that the number of reported cases around the world surged to 306,000, after having dropped to a record low of 123,000 in 2021. As the pandemic has made apparent, our world is connected via pathogens: Large outbreaks in other countries, where vaccination coverage may be low, have a tendency to seed tiny outbreaks in the U.S., where coverage has been pretty high, but narrow and persistent cracks in our defenses still remain. (In 2022, more than half of the world’s unvaccinated infants were concentrated in just 10 countries; some of these are measles hotspots at this moment.) This also helps explain why so many Americans got measles in 2019. That was a catastrophic year for measles around the world, with 873,000 reported cases in total, the most since 1994. We had pretty good protection then, but the virus was everywhere—and so, the virus was here.

    In high-income countries such as the U.S., Ferrari told me, “clustering of risk” tends to be the source of measles outbreaks more than minor changes in vaccine coverage overall. Even in 2019, when more than 95 percent of American kindergarteners were getting immunized, we still had pockets of exposure where protection happened to be weakest. By far the biggest outbreak from that year occurred among Hasidic Jewish populations in New York State. Measles was imported via Israel from the hot spot of Ukraine, and took off within a group whose vaccination rates were much, much lower than their neighbors’. In the end, more than 1,100 people were infected during that outbreak, which began in October 2018 and lasted for nearly a year. “A national vaccination rate has one kind of meaning, but all outbreaks are local outbreaks,” Noel Brewer, a professor at the University of North Carolina at Chapel Hill and a member of the federal Advisory Committee on Immunization Practices, told me. “They happen on a specific street in a specific group of houses, where a group of people live and interact with each other. And those rates of vaccination in that specific place can drop well below the rate of coverage that will forestall an outbreak.”

    We’ve seen this time and time again over the past decade. When bigger outbreaks do occur in the U.S., they tend to happen in tight-knit communities, where immunization norms are radically out of sync with those of the rest of American society, politics aside. In 2014, when an outbreak of nearly 400 cases took hold in Ohio, almost entirely within the Amish community, the local vaccination rate was estimated to be about 14 percent. (The statewide number for young children at that time was more than 95 percent.) In 2011 and 2017, measles broke out among the large Somali American community in Minnesota, where anti-vaccine messaging has been intense, and where immunization rates for 2-year-olds dropped from 92 percent 20 years ago to 35 percent in 2021. An outbreak from the end of 2022, affecting 85 people in and around Columbus, Ohio, may well be linked to the nation’s second-biggest community of Somalis.

    Care must be taken in how these outbreaks are discussed. In Minnesota, for example, state health officials have avoided calling out the Somali community, for fear of stigmatizing. But another sort of trouble may arise when Americans overlook exactly who’s at risk, and exactly why. Experts broadly agree that the most effective way to deal with local outbreaks is with local interventions. Brewer pointed out that during the 2019 outbreak in New York, for example, nurses who belonged to local Jewish congregations took on the role of vaccine advocates. In Minnesota, the Department of Health has brought on more Somali staff, who coordinate with local Somali radio and TV stations to share its message. Yet these efforts can be obscured by news coverage of the crisis that points to a growing anti-science movement and parents giving up on vaccination all across the land. When measles spread among New York’s orthodox Jews, The New York Times reported on “an anti-vaccine fervor on the left that is increasingly worrying health authorities.” When the virus hit Columbus, NBC News noted that it was “happening as resistance to school vaccination requirements is spreading across the country.”

    Two different public-health responses can be undertaken in concert, the experts told me: You treat the problem at its source, and you also take the chance to highlight broader trends. A spate of measles cases in one community becomes an opportunity for pushing vaccination everywhere. “That’s always an important thing for us to do,” Ferrari said. Even so, the impulse to nationalize the problem will have its own, infelicitous effects. First, it’s meaningfully misleading. By catastrophizing subtle shifts in vaccination rates, we frighten many parents for no reason. By insisting that every tiny outbreak is a product of our national politics, we distract attention from the smaller measures that can and should be taken—well ahead of any upsurge of disease—to address hyperlocal vaccination crises. And by exaggerating the scale of our divisions—by asserting that we’ve seen a dangerous shift on a massive scale, or an anti-vaccine takeover of the Republican Party—we may end up worsening the very problem that worries us the most.

    We are a highly vaccinated nation, our politics notwithstanding. Telling people otherwise only fosters more division; it feeds the feeling that taking or refusing measles shots is an important mode of self-expression. It further polarizes health behavior, which can only widen the cracks in our defenses. “We have become quite militant and moralistic about vaccination,” Brewer told me, “and we probably would do well to be less absolute.” Measles outbreaks overseas are growing; measles outbreaks here will follow. Their specific causes ought not be ignored.

    Daniel Engber

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  • A 62-Year-Old German Man Got 217 Covid Shots—and Was Totally Fine

    A 62-Year-Old German Man Got 217 Covid Shots—and Was Totally Fine

    A 62-year-old man in Germany decided to get 217 Covid-19 vaccinations over the course of 29 months —for “private reasons.” But, somewhat surprisingly, he doesn’t seem to have suffered any ill effects from the excessive immunization, according to a newly published case study in The Lancet Infectious Diseases.

    The case is just one person, of course, so the findings can’t be extrapolated to the general population. But, they conflict with a widely held concern among researchers that such overexposure to vaccination could lead to weaker immune response. Some experts have raised this concern in discussions over how frequently people should get Covid-19 booster doses.

    In cases of chronic exposure to a disease-causing germ, “there is an indication that certain types of immune cells, known as T-cells, then become fatigued, leading to them releasing fewer pro-inflammatory messenger substances,” according to co-lead study author Kilian Schober from the Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene. This, along with other effects, can lead to “immune tolerance” that leads to weaker responses that are less effective at fighting off a pathogen, Schober explained in a news release.

    The German man’s extreme history of hypervaccination seemed like a good case to look for evidence of such tolerance and weaker responses. Schober and his colleagues learned of the man’s case through news headlines—officials had opened a fraud investigation against the man, confirming 130 vaccinations over nine months, but no criminal charges were ever filed. “We then contacted him and invited him to undergo various tests in Erlangen [a city in Bavaria],” Schober said. “He was very interested in doing so.” The man then reported an additional 87 vaccinations to the researchers, which in total included eight different vaccine formulations, including updated boosters.

    The researchers were able to collect blood and saliva samples from the man during his 214th to 217th vaccine doses. They compared his immune responses to those of 29 people who had received a standard three-dose series.

    Throughout the dizzying number of vaccines, the man never reported any vaccine side effects, and his clinical testing revealed no abnormalities related to hypervaccination. The researchers conducted a detailed look at his responses to the vaccines, finding that while some aspects of his protection were stronger, on the whole, his immune responses were functionally similar to those from people who had far fewer doses. Vaccine-spurred antibody levels in his blood rose after a new dose but then began declining, similar to what was seen in the controls.

    His antibodies’ ability to neutralize SARS-CoV-2 appeared to be between fivefold and 11-fold higher than in controls, but the researchers noted that this was due to a higher quantity of antibodies, not more potent antibodies. Specific subsets of immune cells, namely B-cells trained against SARS-CoV-2’s spike protein and T effector cells, were elevated compared with controls. But they seemed to function normally. As another type of control, the researchers also looked at the man’s immune response to an unrelated virus, Epstein-Barr, which causes mononucleosis. They found that the unbridled immunizations did not negatively impact responses to that virus, suggesting there were no ill effects on immune responses generally.

    Last, multiple types of testing indicated that the man has never been infected with SARS-CoV-2. But the researchers were cautious to note that this may be due to other precautions the man took beyond getting 217 vaccines.

    “In summary, our case report shows that SARS-CoV-2 hypervaccination did not lead to adverse events and increased the quantity of spike-specific antibodies and T cells without having a strong positive or negative effect on the intrinsic quality of adaptive immune responses,” the authors concluded. “Importantly,” they added, “we do not endorse hypervaccination as a strategy to enhance adaptive immunity.”

    This story originally appeared on Ars Technica.

    Beth Mole, Ars Technica

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  • Ron DeSantis’s Surgeon General Tells Parents It’s Okay to Send Their Unvaccinated Kids to School Amid Measles Outbreak

    Ron DeSantis’s Surgeon General Tells Parents It’s Okay to Send Their Unvaccinated Kids to School Amid Measles Outbreak

    In 2021, Ron DeSantis appointed Joseph Ladapo the surgeon general of Florida, after Ladapo’s op-eds questioning mask-wearing, COVID-19 vaccines, and other public health measures caught the governor’s eye. In the ensuing years, Ladapo has recommended children should not receive the COVID vaccine, has “weaponize[d] bad science to spread anti-vaccine disinformation as official policy,” and has personally “altered key findings in [a] study on Covid-19 vaccine safety.” Now, Ladapo is bringing his medical point of view to a measles outbreak that he appears happy to let explode on his watch.

    In a letter sent to parents this week, Ladapo alerted them to a cluster of measles cases that had been identified in Manatee Bay Elementary School and wrote that “it is normally recommended that individuals without history of prior infection or vaccination stay home for up to 21 days,” as “up to 90% of individuals without immunity will contract measles if exposed.” Having said that? He’s cool with people sending their unvaccinated children to school, despite that whole thing about 90% of unvaccinated people likely contracting the disease. The Florida Department of Health, Ladapo said, “is deferring to parents or guardians to make decisions about school attendance.”

    Not surprisingly, health experts who actually believe in science have said such guidance is wildly irresponsible, with at least one blaming Ladapo for the outbreak. “The reason why there is a measles outbreak in Florida schools is because too many parents have not had their children protected by the safe and effective measles vaccine,” John P. Moore, a professor of microbiology and immunology at Weill Cornell Medical College, told The Washington Post. “And why is that? It’s because anti-vaccine sentiment in Florida comes from the top of the public health food-chain: Joseph Ladapo.” Dr. Ben Hoffman, president of the American Academy of Pediatrics, told the outlet the guidance from Florida “runs counter to everything I have ever heard and everything that I have read. It runs counter to our policy. It runs counter to what the [Centers for Disease Control and Prevention] would recommend.” (As the Post notes, measles can cause severe health complications, including death.)

    Patsy Stinchfield, president of the National Foundation for Infectious Diseases, told the Post the outbreak will become a major threat to the community if unvaccinated people who’ve been exposed to the disease don’t follow health recommendations like staying at home during the time they may be contagious. In other words, things could get a lot worse if people listen to the Florida surgeon general.

    Ladies and gentlemen, the modern Republican Party

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  • Measles Strikes a Florida Elementary School With Over 100 Unvaccinated Kids

    Measles Strikes a Florida Elementary School With Over 100 Unvaccinated Kids

    Florida health officials on Sunday announced an investigation into a cluster of measles cases at an elementary school in the Fort Lauderdale area with a low vaccination rate, a scenario health experts fear will become more and more common amid slipping vaccination rates nationwide.

    On Friday, Broward County Public School reported a confirmed case of measles in a student at Manatee Bay Elementary School in the city of Weston. A local CBS affiliate reported that the case was in a third-grade student who had not recently traveled. On Saturday, the school system announced that three additional cases at the same school had been reported, bringing the current reported total to four cases.

    On Sunday, the Florida Department of Health in Broward County (DOH-Broward) released a health advisory about the cases and announced it was opening an investigation to track contacts at risk of infection.

    At Manatee Bay Elementary School, the number of children at risk could be over 100 students. According to a Broward County vaccine study reported by the local CBS outlet, only 89.31 percent of students at Manatee Bay Elementary School were fully immunized in the 2023/2024 school year, which is significantly lower than the target vaccination coverage of 95 percent. The school currently has 1,067 students enrolled, suggesting that up to 114 students are vulnerable to the infection based on their vaccination status.

    Measles is one of the most contagious viruses known. It spreads via respiratory and airborne transmission. The virus can linger in air space for up to two hours after an infected person has been in an area. People who are not vaccinated or have compromised immune systems are susceptible, and up to 90 percent of susceptible people exposed to the virus will become infected. Measles symptoms typically begin around eight to 14 days after exposure, but the disease can incubate for up to 21 days. The symptoms begin as a high fever, runny nose, red and watery eyes, and a cough before the telltale rash develops. Infected people can be contagious from four days before the rash develops through four days after the rash appears, according to the Centers for Disease Control and Prevention. About 1 in 5 unvaccinated people with measles are hospitalized, the CDC adds, while 1 in 20 infected children develop pneumonia and up to 3 in 1,000 children die of the infection.

    Those who are not immunocompromised and are fully vaccinated against measles (who have received two doses of the Measles, Mumps, and Rubella (MMR) vaccine) are generally not considered at risk. The two doses are about 97 percent effective at preventing measles, and protection is considered to be life-long.

    The DOH-Broward said it is now “identifying susceptible contacts that may be candidates for post-exposure prophylaxis through MMR or immunoglobulin.”

    While the risk of measles is generally low in the US—the country declared it eliminated in 2000—the threat of large outbreaks is growing as vaccination rates slip. Many cases in the US are linked to travel from countries where the virus still circulates. But, if a travel-related case lands in a pocket with low vaccination coverage, the virus can take off. Such was the case in 2019, when the country tallied 1,274 measles cases and nearly lost its elimination status.

    Health officials typically consider vaccination coverage of 95 percent or greater sufficient to protect from ongoing transmission. In the years since the COVID-19 pandemic began, vaccination rates among US kindergarteners have slipped to 93 percent, and vaccination exemptions reached an all-time high in the latest data from the 2022-2023 school year. There are now at least 10 states that have vaccination exemption rates above 5 percent, meaning that even if every non-exempt child is vaccinated, those states will not have enough coverage to reach the 95 percent target.

    The CDC has tallied 20 measles cases in the US so far this year. But that is the tally as of February 15; it does not include any of the Florida cases reported since Friday. In 2023, there were 58 measles cases reported to the CDC.

    This story originally appeared on Ars Technica.

    Beth Mole, Ars Technica

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