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Tag: University of Miami

  • UM researchers hope they took big step in fighting Alzheimer’s disease

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    A University of Miami team conducted research that might create more effective treatments for Alzheimer’s disease and perhaps lead ‘to a cure,’ UM said.

    A University of Miami team conducted research that might create more effective treatments for Alzheimer’s disease and perhaps lead ‘to a cure,’ UM said.

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    In a new study that could have significant implications for future Alzheimer’s treatment, researchers at the University of Miami have possibly figured out how to combat one of the early signs of the neurodegenerative disease.

    In the study published in the Journal of the Alzheimer’s Association in December 2025, two Ph.D. students in the College of Arts and Sciences’ Department of Biology conducted research that could help trailblaze more effective treatments for Alzheimer’s disease, “perhaps even leading to a cure for the memory-robbing disorder that affects more than 7 million adults in the U.S.,” UM shared on Thursday.

    By using a mouse model with Alzheimer’s, researchers Supriya Chakraborty and Zeynad Tabrizi found that activating Piezo1 — a mechanosensitive ion channel that is functionally expressed in blood vessels — improved microvascular flow and neurovascular coupling in the mouse model.

    According to the research duo, reduced blood flow and impaired vascular responses in the brain are early features of Alzheimer’s and contribute to the disease’s progression.

    “While our study was able to improve and actually restore such functions in a mouse model with the disease, we believe such a method may hold great promise as a therapeutic strategy for humans,” Tabrizi said.

    Additionally, the researchers employed the pharmacological activation of Piezo1 to improve functional hyperemia — the localized increase of blood flow to a specific tissue or organ, such as the brain or muscles, in response to increased metabolic activity or function.

    “It’s another major steppingstone in the race to solve the mystery of Alzheimer’s,” Chakraborty said. “But further investigation is needed, which is our goal.”

    According to UM, Chakraborty might have been studying insects in a lab had it not been for an immunology instructor who taught him in India about the “superheroes” inside him: immunity cells.

    “That really fascinated me,” he said. “My focus shifted from entomology to wanting to solve illnesses that affect humans, specifically neurodegenerative disorders.”

    Meanwhile, Tabrizi took a different path to studying conditions that damage and destroy parts of the human nervous system. She had long been a student of immunology and neuroscience in her home country of Iran, researching the causes of disorders like schizophrenia and autism, UM said.

    “I had some experience working in the industry,” Tabrizi said. “But my heart was in academia.”

    For Tabrizi, the study came on the heels of other dementia-related research that she conducted at UM. While working with former Department of Biology neuroscientist Oliver Bracko, she investigated how the immune system might factor in the progression of neurodegenerative diseases like Alzheimer’s. In the research, she focused on neutrophils — a type of white blood cell. In previous studies that she conducted, neutrophils were shown to block blood vessels and contribute to blood-flow reduction to the brain in mouse models.

    “Alzheimer’s is a disease that not only affects the patient but also family members, who are often the ones who end up caregiving for a loved one with the disorder,” Tabrizi said. “So, our work will aid people on all fronts of battling the disease.”

    This report was produced by Miami Herald news partner CBS News Miami.

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    Hunter Geisel

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  • Indiana and Miami students reflect on season lead-up to football championship

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    The No. 1-ranked Indiana Hoosiers will take on the No. 10 seed Miami Hurricanes in the championship game on Monday night. Indiana student Francisco Cáceres and Miami student Shea McDonald join “The Takeout” to discuss what the season has been like for both schools.

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  • Once Thought Dead, Witness in University of Miami Murder Case is Found Alive — Weeks Before Trial

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    NEED TO KNOW

    • A murder trial is set to proceed after being upended by a revelation that an elderly witness, thought to be dead, is still alive

    • ESPN reporters found Paul Conner, an 81-year-old witness in the murder case against Rashaun Jones, alive in Kentucky. Jones is accused of killing 22-year-old University of Miami football player Bryan Pata in 2006

    • Conner used to live in the same apartment complex as Pata and eventually identified Jones from a photo lineup, ESPN reported

    A murder trial is set to proceed after being upended by a revelation that an elderly witness, previously thought to be dead, is still alive.

    In August 2021, former University of Miami football player Rashaun Jones was charged in the murder of his onetime teammate, 22-year-old Bryan Pata, who was found dead from a gunshot wound to the head in the parking lot of an apartment complex in Miami on Nov. 7, 2006. Jones has pleaded not guilty.

    ESPN reported that prosecutors told the court a witness, Paul Conner, an 81-year-old retiree, was dead, basing their belief on information from a third-party database. Conner used to live in the apartment complex where Pata was killed, and had notified police that he heard a loud noise and saw an individual “jogging” away from an area close to the scene of the crime, according to the outlet, and he later selected Jones from a photo lineup.

    But ESPN reporters located Conner alive when they knocked on his door in Louisville, Ky. weeks before the trial was set to begin. On August 25, he told the outlet he has difficulty recalling the details of the incident. His phone also showed dozens of missed calls, some of which appeared to originate from Miami-area numbers.

    “I’m getting up in years,” he told ESPN. “My memory comes and goes. How long ago was this court case?”

    “ESPN released an article whereby they made contact with our eyewitness in this case, Paul Conner,” a prosecutor told the court during a hearing on Friday, Sept. 19, Miami news station WPLG reported.

    According to the station, the judge ruled that the case is set to proceed on Oct. 6.

    The prosecutor and defense attorney involved in the case could not immediately be reached by PEOPLE to provide additional information about how the trial is moving forward in light of the new information about Conner and it is unclear whether he will testify.

    Never miss a story — sign up for PEOPLE’s free daily newsletter to stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories.

    According to ESPN, prosecutor Cristina Diamond told the judge that in light of the outlet’s reporting, a detective contacted local police in Kentucky to request a visit to Conner’s most recent address.

    “They were able to make contact with Paul Conner. So at this time, what I can tell the court is that Paul Conner is alive,” Diamond said, per ESPN. “I think the state needs to do a little bit of further investigation. It appears that he was very confused and is not certain what the case is about.”

    Read the original article on People

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  • Adding Marijuana To Your St. Patrick’s Day

    Adding Marijuana To Your St. Patrick’s Day

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    Green rivers, big parades and lots of drinks – St. Patrick’s Day definitely has strong traditions. It is a massive festival atmosphere. It is also the top beer-drinking holiday in a bar in the United States. Meaning more people drink beer in bars (as opposed to their homes) than on any other day of the year.  But as cannabis become legal and people start consuming more and drinking less….what about adding marijuana to your St. Patrick’s Day?  BDSA, a leading analytics firm which covers the cannabis industry, just released numbers and data revealing the cannabis industry earned $29.5 billion dollars in 2023. That is a lot of green and a ton of consumers!

    RELATED: The Best Ways To Recover From A Hangover

    For the holiday, green beer is a staple. There is no trick to making the iconic beverage. It is a light-colored beer with a drop of green food coloring added. No flavor change just the color.  It is so popular, the University of Miami students added a new tradition of Green Beer Day when a change of schedule put St. Patrick’s Day in the middle of spring break…when the students are away from campus.

    Photos: Maria Badasian via Unsplash; BENCE BOROS via Unsplash

    Marijuana is also becoming a recreational as well as a medical staple.  California sober is now a national thing and beer sales have been hit by marijuana’s increase.  You might want to put down the calorie filled pint and pick up a green gummy, a green apple vape or just some old fashioned flower.  If you are out and about in a crowd for a parade or a pub crawl, the gummy or vape is the most discreet and most “public” friendly.

    If you are going to mix weed and alcohol, there are few things to remember. Moderate your consumption and make sure you are paying attention. Using weed before drinking alcohol may minimize the effects of alcohol. Don’t get drawn into doing shots or Boilermakers. Both weed and alcohol are depressant drugs. Their effects suppress, impair and inhibit the brain’s ability to function. When alcohol and weed are mixed together, the effects of each individual substance become exaggerated. This can result in a person losing control of their actions .

    RELATED: Science Says Medical Marijuana Improves Quality Of Life

    And the Chicago green river thing? It goes back to 1962 when Mayor Richard J. Daley wanted to turn Lake Michigan green in honor of the holiday. He was persuaded to dye the more manageable Chicago River instead. The Chicago Journeymen Plumbers Union have always been in and charge and use  same green dye plumbers used to find sewage leaks.

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    Anthony Washington

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  • Lightguard: Device could help stop attacks from assailants

    Lightguard: Device could help stop attacks from assailants

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    BYLINE: Barbara Gutierrez

    Newswise — Brian Arwari grew tired of what he calls “the cycle.”

    “We all know the cycle,” said Arwari, associate clinical professor in the Department of Kinesiology and Sports Sciences at the University of Miami School of Education and Human Development, and head of the Neurocognitive Lab.

    “There is a mass shooting. Key people offer thoughts and prayers. There may be a protest and people say, ‘this is ridiculous and it must stop.’ Then people forget until the next time it happens,” he said.

    In 2020, the most recent year for which complete data is available, 45,222 people died from gun-related injuries in the United States, according to the Centers for Disease Control and Prevention. This excludes suicides.

    Churches, banks, shopping malls, offices, schools, synagogues, and convenience stores are some of the venues that have been the sites of major shootings. In 2023, there have been 146 mass shootings—an incident where three or more people die—according to the Gun Violence Archive.

    Wanting to stem what he sees as an epidemic in shootings, Arwari, working with graduate engineering student Luis Carlos Diaz, has designed a device called Lightguard, which—when triggered by a well-placed button—can temporarily dazzle an assailant. 

    The Lightguard Security System is a light-based defensive device that produces a flashing pattern of thousands of lumens in output, temporarily impairing an attacker’s vision. The assailant is functionally blind for about 10 to 20 seconds, with partial visual impairment that may last up to a few minutes. The flashes of light can be repeated to extend the period of disability.

    “You can put two, three, five, or 10 light modules at ‘choke points.’ These are areas of a building that people are forced to go through,” said Arwari.

    Lightguard also functions as an emergency notification system that alerts the police and/or security guards, as well as key people identified by the system, of a potential threat.

    Arwari and Diaz have been working on creating Lightguard for the past three years. The venture has been financed by Ernest Bacharach, a Key Biscayne resident, who was a former managing partner with Advent International, a global private equity firm.

    Arwari has received a patent for the system from the U.S. Patent and Trademark Office. He created the device working on the premise that a human’s nervous system can oscillate between two extremes of a continuum.

    “You are either in rest or digest, which means that you are relaxed. On the other end, you are in fight or flight mode,” he said. Lightguard switches the attacker into the flight mode, he added. The light startles the attacker and most times when they are startled, they will run away. “The assailant goes from being the hunter to being the hunted,” he said.

    In addition to public spaces, Lightguard can be installed in private homes or buildings to deter home invaders or robbers, according to Arwari. In a home with two floors, the light modules can be placed at the top of the stairs. In a convenience store, the modules could be hung behind the cashier.

    “The only way to stop an assailant is to defend yourself,” said Arwari. “If you have to go into hand-to-hand combat with someone with a gun you are at a great disadvantage. But if that person is visually impaired, then you have a greater chance.” 

    As an engineering student, Diaz worked on the electronic and technological part of Lightguard.  

    “These lights are extremely strong and they flash in a random pattern,” Diaz pointed out.

    Lightguard has been tested by local police departments and SWAT teams, noted Arwari. He said many of the law enforcement agencies believe the system could be effective.

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    University of Miami

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  • UConn Knocks Down Miami On Way To NCAA Championship Game

    UConn Knocks Down Miami On Way To NCAA Championship Game

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    HOUSTON (AP) — Nobody was guarding UConn’s best player. So Adama Sanogo spun the ball to get his fingers just right, set his feet behind the 3-point line and splashed in the shot. Then, less than a minute later, he did it again.

    It was as much basketball clinic as highlight video — and all of it perfectly fitting for the Huskies, who are methodically steamrolling through a March Madness bracket that has been a free-for-all everywhere else.

    UConn doled out another drama-free beatdown Saturday, getting 21 points and 10 rebounds from Sanogo to dispatch Miami 72-59 and move one win from the school’s fifth national title.

    “There’s a lot of teams that want to play Monday,” Sanogo said. “It means a lot to us.”

    Jordan Hawkins overcame his stomach bug and scored 13 for the Huskies, who came into this most unexpected Final Four as the only team with any experience on college basketball’s final weekend and with the best seeding of the four teams in Houston — at No. 4.

    Connecticut guard Andrew Hurley (20) celebrates after scoring during their win against Miami in the Final Four on Saturday.

    AP Photo/David J. Phillip

    Against fifth-seeded Miami, they were the best team on the court from beginning to end. Starting with three straight 3s — one jumper from Hawkins and two of those set shots from Sanogo — UConn took a quick 9-0 lead and never trailed.

    “This is something that I worked on all summer, especially shooting,” Sanogo said.

    On Monday in the title game, the Huskies will face San Diego State, which became the first team to hit a buzzer-beater while trailing in a Final Four game for a 72-71 victory over Florida Atlantic. UConn was an early 7 1/2-point favorite, according to FanDuel Sportsbook.

    “They’re one of the best teams in the country,” UConn coach Dan Hurley said of the Aztecs. “And I think it’s fitting that both of us kind of earned our way into this title game.”

    Miami forward Norchad Omier is blocked by Connecticut during the second half of a Final Four game in the NCAA Tournament on Saturday.
    Miami forward Norchad Omier is blocked by Connecticut during the second half of a Final Four game in the NCAA Tournament on Saturday.

    But while the early game was an all-timer, the nightcap was simply more of the same from the Huskies (30-8).

    The 13-point win was UConn’s closest since the brackets came out. The Huskies are the sixth team since the tournament expanded to 64 teams in 1985 to reach the title game with five straight double-digit victories. It’s an impressive list of behemoths with a knack for closing: Four of the first five went on to win the championship.

    Some thought Miami (29-8), with the nation’s fifth-ranked offense and four players who have scored 20 points at least three times this season, might be the team to slow this Huskies juggernaut. Not to be.

    Isaiah Wong led the ’Canes with 15 points on 4-for-10 shooting. Harassed constantly by Sanogo, 7-foot-2 Donovan Clingan and the rest of Connecticut’s long-armed, rangy perimeter players, Miami, which came in with the nation’s fifth-best offense, shot 25% in the first half and 33.3% for the game.

    “Obviously what we tried to do not only didn’t work, I couldn’t even recognize it,” Miami coach Jim Larranaga said. “Offensively we were out of sync, but defensively we were too.”

    Not that UConn was all boring. The Huskies enjoyed their own sort of buzzer-beater in the form of a 3 from Alex Karaban that sent the Huskies jogging into the locker room with a 13-point lead at halftime.

    They built it to 20 before the first TV timeout of the second half. By then, Jim Nantz, calling his last Final Four, could start saving his voice for Monday.

    Miami did get it under double digits a few times, but this never got interesting.

    Connecticut guard Joey Calcaterra (3) celebrates after their win against Miami in a Final Four game on Saturday.
    Connecticut guard Joey Calcaterra (3) celebrates after their win against Miami in a Final Four game on Saturday.

    Not helping: Hurricanes guard Nijel Pack missed about five minutes after managers had trouble locating a substitute for a busted shoe. Pack finished with eight points, and Jordan Miller, who hit all 20 shots he took from the floor and the line in Miami’s Elite Eight win, went 4 for 10 for 11 points. Only one Miami player made more than half his shots.

    “I’m a defensive guy first and foremost,” Hurley said. “I just love the way we guarded them. They’re one of the best offenses in the country, and we really disrupted them.”

    UConn had five blocks, including two from Sanogo, and 19 assists, led by eight from Tristen Newton — both signs of the sort of all-around effort the Huskies have been putting in since the start of February, when they began the bounce back from a six-loss-in-eight-games stretch that halted their momentum.

    That cold stretch is a big reason they were seeded only fourth for March. Now, it’s April and the number UConn is thinking about is “5” — as in, a fifth title that will come if it can keep this up for one more game.

    “Maybe it was a little bit delusional,” Huskies guard Andre Jackson Jr. said, “but we always knew we were the best team in our mind.”

    AP March Madness coverage: https://apnews.com/hub/march-madness and bracket: https://apnews.com/hub/ncaa-mens-bracket and https://apnews.com/hub/ap-top-25-college-basketball-poll and https://twitter.com/AP_Top25

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  • Unique hybrid reefs deployed off Miami Beach

    Unique hybrid reefs deployed off Miami Beach

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    BYLINE: Robert C. Jones Jr. and Janette Neuwahl Tannen

    Newswise — The first piece of a series of concrete structures was lowered into the water off the coast of Miami Beach on Wednesday morning, a massive crane on the deck of a floating barge hoisting the unit into the air and sinking it to the seabed. 

    During the next six hours, crewmembers aboard the barge would repeat that process until the structures, some stacked on top of each other, were settled on the seafloor, 14 feet below the surface. 

    To casual observers onshore, the daylong operation might have seemed routine. But this maritime activity was hardly run-of-the-mill. 

    In a project that could pave the way for greater efforts to protect coastlines from sea level rise and storm surge and serve as an innovative base structure to develop thriving coral reefs, a team of researchers and scientists from the University of Miami sunk 27 interlocking concrete structures that will form two hybrid reef units 1,000 feet offshore of North Beach Oceanside Park, at the northern edge of Miami Beach. 

    The units are the centerpiece of a project called Engineering Coastal Resilience Through Hybrid Reef Restoration, or ECoREEF, which combines cement- and nature-based strategies to foster coastal resilience. Supported by the University’s Laboratory for Integrative Knowledge (U-LINK) and the City of Miami Beach, the project was developed at a time when coral reefs are struggling to survive. A recent study indicates that half of the world’s living coral reefs have died since the 1950s. Meanwhile, other research has shown that healthy and complex coral reefs are able to buffer up to 97 percent of the energy from waves and can also reduce flooding frequency.

    “Coral reefs are disappearing at alarming rates throughout the world as a result of disease and warming oceans, so our reefs have lost a lot of the structure they need to reduce wave energy,” said ECoREEF lead investigator, Diego Lirman, an associate professor of marine biology and ecology at the University’s Rosenstiel School of Marine, Atmospheric, and Earth Science. “By placing these [hybrid] reefs near the shoreline and planting stress-tolerant corals on them, we hope to recover some of the lost services provided by healthy reefs, such as coastal protection, and to build a habitat for organisms like fish and lobsters.” 

    One of the hollow structures submerged this week was shaped like a trapezoid, with rocks on its outer surface to mimic the texture of coral reefs and to attract marine life. The other unit is a series of hexagons, the iconic honeycomb-like shape that is being incorporated into more and more projects, including the powerful Webb Telescope. Perforated to allow seawater to flow through them, the hollow, hexagonal SEAHIVE structures—tubes that look like honeycomb and each weighing 2,500 pounds—are stacked in a pyramid-like shape and attached to a few solid concrete SEAHIVEs to enhance the stability of the structure. 

    To build the hybrid structures, researchers also used an eco-friendly concrete mixture, with composite reinforcements instead of steel, both for durability and to attract marine life. 

    Haus and Rhode-Barbarigos peer through a six-foot-tall perforated SEAHIVE unit, which they designed with other faculty members, on the barge that lowered dozens of the units into the ocean.

    “Designing structures to dissipate wave energy while providing a hospitable environment for corals has been a challenge,” said Landolf Rhode-Barbarigos, an assistant professor in the College of Engineering, and one of the project’s lead investigators. “There are no design guidelines for nature, but hopefully this can be translated into something bigger and provide novel solutions for coastal protection.” 

    It was Rhode-Barbarigos, along with Lirman, marine biologist Andrew Baker, ocean scientist Brian Haus, sustainable architect Sonia Chao, and communications expert Jyotika Ramaprasad, who joined forces in 2018 to address challenges of coastal resilience. They hope the ECoREEF project will lead to a better understanding of the types of structures that can help protect South Florida’s vulnerable coastline from erosion and storm surge. 

    “We want to see how these two different alternatives for a hybrid, engineered structure and a natural reef compare,” Haus said. “This is a research installation, so we’ll be examining it in a variety of ways.” 

    Corals grown at the Rosenstiel School’s three nurseries will eventually be attached to the hybrid reefs, allowing them to thrive and replace some of the area’s many coral reefs lost to disease and bleaching that is the result of warming ocean temperatures. 

    “We are hoping that we can get baby corals to attach and get a community that looks similar to a natural reef developing on these structures over time,” Lirman said.  

    But for now, the reefs must get acclimated to their new underwater environment. 

    Divers and drones will help monitor the structures; and soon, researchers will install current meters and wave sensors from the U.S. Geological Survey to measure wave energy and flow on the surface of the reefs, according to Brian Haus, professor and chair of ocean sciences at the Rosenstiel School. 

    After two previous attempts to deploy the structures were called off because of inclement weather, ideal conditions—calm waters and little to no wind—made it possible for crews to sink the structures. 

    Onboard the barge which carried the hybrid reefs—after a tugboat had brought them more than 100-nautical-miles from Fort Pierce to Miami Beach—Haus and Rhode-Barbarigos helped orchestrate the deployment, directing the crane that lowered the structures into the water and making sure the reefs were positioned and stacked correctly on the seabed. A diver who patrolled the seafloor ensured the structures aligned properly.

    “We got our hands a little bit dirty today, but it was worth it,” said Haus, who oversees the Rosenstiel School’s 75-foot-long, 38,000-gallon Alfred C. Glassell, Jr. SUSTAIN Laboratory wind-wave tank, which researchers used to test small-scale versions of the hybrid reefs.  

    Should a tropical cyclone threaten or even strike South Florida this coming hurricane season, the hybrid reefs could get their first big test, which is why the team went through a meticulous permitting process, Rhode-Barbarigos said.

    A grant from U-LINK helped jump-start the project, and the group soon partnered with the City of Miami Beach. The U-LINK initiative was founded in 2018 to offer interdisciplinary faculty teams seed funding to devise novel solutions to pressing societal issues. Since then, 40 other teams have been formed, and many of them have garnered additional external funding. Last summer, Baker, Lirman, Rhode-Barbarigos and Haus, among others, received a massive grant from the Defense Advanced Research Projects Agency (DARPA), a division of the U.S. Department of Defense, to scale up their designs and help protect military and civilian infrastructure along the coast. 

    “This EcoReefs project will give us a test bed for this technology, before we do a deployment of a much larger structure for the DARPA grant elsewhere in Florida,” Lirman pointed out.   

    While the U-LINK project was evolving, Rhode-Barbarigos was also working with Haus and College of Engineering faculty members Antonio Nanni, Esber Andiroglu, and Prannoy Suraneni to develop the SEAHIVE structure through grants from the National Comparative Highway Research Program and the Florida Department of Transportation. Initially created as an alternative to traditional seawalls because of their ability to mitigate wave energy, the honeycomb-shaped SEAHIVE units are also set to be tested at two other South Florida locations. 

    Miami Beach officials are eager to see how both hybrid reefs perform in the waters off North Beach Oceanside Park. 

    “The launch of this experimental [hybrid] reef marks a pivotal moment in our efforts to protect Miami Beach from coastal erosion and restore our coral ecosystem,” said Ricky Arriola, a Miami Beach commissioner. “Not only will this innovative solution help safeguard our shores, but it will also drive ecotourism and further establish Miami Beach as a leader in sustainable coastal management.” 

    Amy Knowles, the city’s chief resilience officer, agreed. “We can’t wait to see how this hybrid reef grows,” she said. “Coral reefs are an important part of marine life, and our coastal resilience to storm surge and sea level rise for Miami Beach and our broader region.” 

    For the faculty members who worked on the project since its inception four years ago, this deployment marked an achievement.

    “It’s been a long adventure, so we’re understandably excited,” Rhode-Barbarigos said. “It’s a milestone moment because we’ll be able to learn from these units both from an engineering and ecological perspective. What we accomplished today is the end of one phase, but the beginning of another.”

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    University of Miami

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  • Neurologist explains autoimmune disease affecting Celine Dion

    Neurologist explains autoimmune disease affecting Celine Dion

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    Newswise — In an emotional video message, superstar singer Celine Dion recently announced on her Instagram that she has Stiff-Person Syndrome—a rare neurological disorder.

    In the five-minute post, Dion shared how Stiff-Person Syndrome was causing spasms that affect her ability to walk and sing.

    “I’ve been dealing with problems with my health for a long time, and it’s been really difficult for me to face these challenges and to talk about everything that I’ve been going through,” Dion said in her video. “It hurts me to tell you that I won’t be ready to restart my tour in Europe in February.”

    Dion, 64, is a Canadian singer perhaps most recognized for her recording of “My Heart Will Go On,” the theme of the Academy Award-winning motion picture “Titanic.” She also has sold more than 250 million records worldwide and has received five Grammy Awards, including Album of the Year in 1993.

    Dr. Kottil Rammohan, a professor of clinical neurology and the past director of the Multiple Sclerosis Center of Excellence at the University of Miami Miller School of Medicine, explained Stiff-Person Syndrome and its treatment.

    What is Stiff-Person Syndrome?

    Stiff-Person Syndrome is an extremely rare neurological disorder. And no one really knows the exact prevalence, but it is thought to be like one to two per million in population. But with that said, there is probably more of it because the milder forms of the disease probably never get diagnosed.

    The manifestation is muscle cramps. And of course, a very mild form of it. Patients may experience this and find it an annoyance, but it really does not interfere with any activities of daily living and may not even make it onto the radar screen as a neurological disorder. When the problem is significant enough, it takes patients to their doctors. And unless they are in the midst of an attack, even then, many people may pass it off as a muscle contraction or cramp.

    The spasms can be so severe that it can tear muscles, break bones, and destroy joints.

    How is Stiff-Person Syndrome diagnosed?

    Once these cramps start to get worse, to the point that they start to interfere with life, and take patients to the emergency room, the doctor who sees them will need to run specific blood tests.

    There have been new tests that have identified specific antibodies in people. The presence of these antibodies can present without Stiff-Person Syndrome and the antibodies can be a marker—so it goes both ways. The antibodies are called anti-glutamic acid decarboxylase (GAD) and anti-amphiphysin antibodies. GAD is an important enzyme that assists in the production of a glutamic acid to gamma amino butyric acid, the main inhibitory neurotransmitter of the central nervous system.

    More likely than not, that antibody is the reason the individual has this disorder. The important thing is that they check for these antibodies; and if both or one is present, they don’t stop there. Sometimes the presence of these antibodies can be a marker for an underlying cancer. It is important to look for and make sure that such a cancer is not present. Usually the cancer affects the lungs—or in women, the breast.

    I recall one instance where the person would go to the emergency room for severe cramps and attacks and they would treat her with medications that relax the muscle. She would go through these treatments, and they would send her home and there would be no diagnosis. Or they gave her a label that didn’t really mean much. One day, her friend did a Google search. And she learned about Stiff-Person Syndrome. She wrote it down and told her doctor about it, and he checked her blood for the antibodies. The GAD antibody upper limit of normal is one to four—that’s considered normal. This patient’s GAD antibody was one to 68,000. She had some of the worst Stiff-Person Syndrome we had seen.

    Who is most at-risk of contracting or being diagnosed with this disorder?

    Usually, autoimmune disorders are more common in women and in young people rather than old. All the people who I have taken care of at UM—really a handful of them—all of them have been women.

    Is there a treatment for it? What are some ways to manage the symptoms?

    You can manage the symptoms and also treat the underlying problem of the offending antibody. First, of course, is giving something to relax the muscles. Something like Valium, which is excellent for this condition, or Baclofen. Another way to manage the symptoms would be to install a pump in the spine that sends medication through spinal fluid that helps with the spasms in the legs.

    After treating for the muscle spasms, it is important to try to remove the offending antibody. The treatment involves plasma exchange or giving medications to modulate the immune system, including drugs like intravenous immunoglobulin or anti B cell therapies.

    Because it is so rare, how important is it for someone like Celine Dion to raise awareness about this disease?

    Without a doubt, it is important for not only her, but even physicians, to bring awareness to the disease.

    Emergency rooms should be aware, because a person may come in with severe muscle spasms and we don’t want to just treat the spasms and send them home. Some people with these types of symptoms can be mistaken as addicts. We have to realize that this person is not a junkie, they want relief for the problem that they’re going through.

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    University of Miami

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  • Fraternity shuts down UM chapter after drugging accusations, disturbing video come to light

    Fraternity shuts down UM chapter after drugging accusations, disturbing video come to light

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    CORAL GABLES, Fla. – Sigma Phi Epsilon’s chapter at the University of Miami has been permanently shut down after a disturbing video came to light last week.

    According to UM’s student newspaper, The Miami Hurricane, which obtained the video, the footage showed numerous SigEp members chanting about murdering and raping women before they hosted their “Adult Swim” party on Oct. 1 at an off-campus house in Coral Gables.

    Multiple women who attended the party claimed they noticed white powder in their drinks and said they knew people who became extremely ill despite only having a couple drinks.

    “It’s just crazy that I go to school with people that do things like that and the school allows them to stay here and that, even if it isn’t true, allegations are still allegations and they come from somewhere,” student Victoria Toro said.

    The fraternity’s National Board of Directors unanimously agreed to revoke the UM chapter last Friday.

    “The National Headquarters received admissible information that SigEp members violated policy and engaged in actions that are not aligned with the values of this Fraternity,” the fraternity said in a statement. “We expect SigEp chapters to provide their members and campus community a safe and supportive environment. That’s the cornerstone of a positive Fraternity and university experience, so we take that expectation seriously and hold our chapters to that standard.”

    SigEp opened its UM chapter in 1949.

    “The University of Miami continually communicates a clear set of policies and expectations to all of our Greek organizations that are designed to encourage a safe, healthy, and positive experience for UM students,” the university said in a statement. “The University received allegations the Sigma Phi Epsilon chapter violated university policy and participated in behavior that is inconsistent with the values and expectations of the university community and their national fraternity. We have partnered with Sigma Phi Epsilon for 73 years, and we support their decision to close the chapter effective immediately.”

    Students who spoke to Local 10 News Monday said they agreed with the decision to remove the fraternity’s charter from campus.

    “It’s definitely a big step forward in removing a lot of misogyny in frat culture,” student Kaine Dudley said.

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