ReportWire

Tag: Surgery

  • New Hampshire man resumes dialysis after record 271 days living with a pig kidney

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    WASHINGTON — A New Hampshire man is resuming dialysis after living with a gene-edited pig kidney for a record 271 days, doctors said Monday. His experience is helping researchers in their quest for animal-to-human transplants.

    Tim Andrews, 67, had the organ removed on Oct. 23 because its function was declining, according to Mass General Brigham. In a statement, his transplant team called Andrews “a selfless medical pioneer and an inspiration” to patients with kidney failure.

    Andrews’ experience illustrates lessons researchers have learned with each experiment involving what’s called xenotransplantation. The first attempts using pig organs gene-edited to be more humanlike – two hearts and two kidneys – were short-lived.

    Then researchers began considering patients not nearly as sick as prior recipients for these experiments — and an Alabama woman’s pig kidney lasted 130 days before it had to be removed last spring, the record Andrews surpassed.

    More than 100,000 people, most needing kidneys, are on the U.S. transplant list, and thousands die waiting.

    Andrews, of Concord, New Hampshire, knew his blood type is particularly hard to match and sought an alternative, getting into shape to qualify for Mass General’s xenotransplant pilot study. His doctors said he remains on the transplant list.

    In June, the Mass General team transplanted a pig kidney into another New Hampshire man who continues to fare well. The pilot study is set to conclude with a third pig kidney transplant later this year.

    Two companies, eGenesis and United Therapeutics, are preparing to begin more rigorous clinical trials of pig kidney transplants.

    Surgeons in China also are pursuing this new field, reporting a pig kidney transplant last spring and separately a transplanted pig liver that had to be removed after 38 days.

    ___

    The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

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  • A Bomb in Gaza’s Rubble Wounds Twins Who Thought It Was a Toy

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    GAZA CITY, Gaza Strip (AP) — The Shorbasi family was sitting in their severely damaged house in Gaza City, enjoying the relative calm of the ceasefire. Then they heard an explosion and rushed outside to find their 6-year-old twins bleeding on the ground.

    The boy, Yahya, and his sister, Nabila, had discovered a round object while playing. One touch, and it went off.

    “It was like a toy,” their grandfather, Tawfiq Shorbasi, said of the unexploded ordnance, after the children were rushed to Shifa hospital on Friday. “It was extremely difficult.”

    Hundreds of thousands of Palestinians are seizing the chance to return to what’s left of their homes under the ceasefire that began on Oct. 10. But the dangers are far from over as people, including children, sift through the rubble for what remains of their belongings, and for bodies unreachable until now.

    Shorbasi said the family had returned home after the ceasefire took hold. Gaza City had been the focus of the final Israeli military offensive before the deal was reached between Israel and Hamas.

    “We’ve just returned last week,” the grandfather said at Shifa hospital, fighting back tears. “Their lives have been ruined forever.”

    The boy, Yahya, lay on a hospital bed with his right arm and leg wrapped in bandages. Nabila, now being treated at Patient’s Friends hospital, had a bandaged forehead.

    Both children’s faces were freckled with tiny shrapnel wounds.

    A British emergency physician and pediatrician working at one of the hospitals told The Associated Press the twins had life-threatening injuries including a lost hand, a hole in the bowel, broken bones and potential loss of a leg.

    The children underwent emergency surgery and their conditions have relatively stabilized, the doctor said. But concerns remain about their recovery because of Gaza’s vast lack of medicine and medical supplies, said Dr. Harriet, who declined to give her last name because her employer hadn’t authorized her to speak to the media.

    “Now it’s just a waiting game so I hope that they both survive, but at this point in time I can’t say, and this is a common recurrence,” she said.

    Health workers call unexploded ordnance a major threat to Palestinians. Two other children, Yazan and Jude Nour, were wounded on Thursday while their family was inspecting their home in Gaza City, according to Shifa hospital.

    Gaza’s Health Ministry, which operates under the Hamas-run government, said five children were wounded by unexploded ordnance over the past week, including one in the southern city of Khan Younis.

    “This is the death trap,” Dr. Harriet said. “We’re talking about a ceasefire, but the killing hasn’t stopped.”

    Already over 68,500 Palestinians have died in the war, according to Gaza’s Health Ministry, which doesn’t distinguish between civilians and combatants in its count. The ministry maintains detailed casualty records that are seen as generally reliable by U.N. agencies and independent experts. Israel has disputed them without providing its own toll.

    Luke Irving, head of the U.N. Mine Action Service, UNMAS, in the Palestinian territories, has warned that “explosive risk is incredibly high” as both aid workers and displaced Palestinians return to areas vacated by the Israeli military in Gaza.

    As of Oct. 7, UNMAS had documented at least 52 Palestinians killed and 267 others wounded by unexploded ordnance in Gaza since the war began. UNMAS, however, said the toll could be much higher.

    Irving told a United Nations briefing last week 560 unexploded ordnance items have been found during the current ceasefire with many more under the rubble. Two years of war have left up to 60 million tons of debris across Gaza, he added.

    In the coming weeks, additional international de-mining experts are expected to join efforts to collect unexploded ordnance in Gaza, he said.

    “As expected, we’re now finding more items because we’re getting out more; the teams have more access,” he said.

    Magdy reported from Cairo.

    Copyright 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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  • Jon Bon Jovi talks first tour since vocal cord surgery, new album and Bruce Springsteen

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    LONDON — Bon Jovi will embark on their first tour in four years in 2026 — and it’s more than just a victory lap.

    In 2022, singer Jon Bon Jovi saw a doctor who said one of his vocal cords was atrophying. He had major surgery and has been in extensive rehab since. These new shows — kicking off with four nights at New York’s Madison Square Garden in July before heading to Edinburgh, Scotland; Dublin and London — are the result of all the work.

    In an interview with The Associated Press at Wembley Stadium, where Bon Jovi will close their “Forever” Tour in September 2026, frontman Jon Bon Jovi discusses the forthcoming gigs, his band and their latest collaborative album, “Forever (Legendary Edition).”

    This interview has been edited for length and clarity.

    BON JOVI: It’s a lot of hits that you know. But I think more than ever, I’m really in touch with the idea of gratitude and joy, and this idea of this energy that happens between me and that audience. And it’s been so long since I’ve done it that I can really re-appreciate how much that means to me. And that’s really the only motivation for me to want to do it anymore. It’s just to go out there and say, “Touch.” You know? It’s gonna be good.

    BON JOVI: I agree with you. I agree. You know, that optimism and tribalism but with joy as the underlying thing, you know, that fact that brings you together.

    BON JOVI: Well, it’s home. I get to sleep in my own bed at night, which was integral to this equation, that I would play a bunch of nights there to start it as long as I was going home at night. And then we’ll go and do these ( U.K. and Ireland shows) and that’s going to be it. That’s it for the year. Just get my feet back in the pool, you know, and get in there slowly, wait around, and after I have that joy and good health then we could talk about doing some work. But this should be about, don’t even bring a suitcase. We’re just going out for the weekend.

    BON JOVI: Really, really good. I could go tonight. I can tell that I woke up this morning at 7 a.m. and you’re ready to talk and you go, “Yeah, it just works.”

    BON JOVI: Well, the truth is, here’s a band of brothers who at this stage and phase of their lives could have said, “We’ve had it. We’re done. Good luck to you. We are going to go and do solo projects. We will go and join someone else’s band.” They sat in the rehearsal space to this day with me and said, “We got your back.” And how much more grateful can I be than in my darkest hours, each one of them said, “This ain’t about money, boss, let’s go.” And the bond has just gotten bigger and deeper and stronger.

    BON JOVI: It’s amazing, and each of ’em’s contribution has been unique. And from the newest member, Everett Bradley to Phil X, who’s just that guy that wants to play seven nights a week, doesn’t care where he plays, the guy’s nuts. He truly would play seven days a week if he could. And to see him just going, “I’m here, I am here, I’m not going anywhere else,” it’s unbelievable.

    BON JOVI: Well, the thing about the “Forever” album is that we were very proud of it, and it was coinciding with the documentary and the 40th anniversary. When I wasn’t up to it physically, I thought we could reimagine the record by having features on it. In this day and age, people know what features are. I learned about that the hard way. But in doing so, I think they took a great record and made it better. And, you know, I called Robbie Williams. He was the first call I made. He said yes, which made it easier for me to call number two, three, four, seven, eight, nine, 10. Because at first, it’s daunting. You call even your dear friends and go, “Hey, would you do this for me?” Each one of them did it. I think that joy in the record is felt and even just raised the level of the bar.

    BON JOVI: Oh, it’s fantastic. I mean, I’ve looked up to him my whole life. The E Street Band are our Beatles. They were just 25 miles away from where I was as a kid. You know, Highway 9 was out my window. You know, these are, these are my streets, too. And so, it was fabulous because he loved that song (“Hollow Man.”) Even when it was a demo, he’s like, “That’s a really special song.” So, when I called him on that one instead of the obvious single, he was like, “You know, yeah, I get it, I can do that.”

    ___

    AP Music Writer Maria Sherman contributed to this report from New York.

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  • Girl shot in Minneapolis church returns home from the hospital

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    MINNEAPOLIS — A 12-year-old girl who was shot in the head during a deadly attack at a Minneapolis Catholic church in August was released from the hospital Thursday and greeted with cheers as the police chief paraded her around town in a stretch limousine, according to the Minneapolis Star Tribune.

    Sophia Forchas was the most seriously wounded child among those who survived the shooting at the Church of the Annunciation. A shooter opened fire with a rifle through the windows of the church on Aug. 27 and struck some of the nearly 200 children celebrating Mass during the first week of school, killing two and wounding 17 people. The children who died were 8 and 10 years old.

    Forchas was rushed into surgery. Her neurosurgeon, Dr. Walt Galicich, said a bullet had lodged in her brain, causing severe damage, including to a major blood vessel. Surgeons had to remove the left half of her skull to relieve the pressure inside her head. At a Sept. 5 news conference, Galicich had described worrying that Forchas could become “the third fatality in this event.”

    He gave her a hug as she left the Hennepin County Medical Center, the Star Tribune reported, as many others outside held banners and waved.

    Minneapolis Police Chief Brian O’Hara, who escorted Forchas around the city, described her return home as “nothing short of a miracle.”

    She was again greeted with roaring applause and plenty of hugs as they pulled into her school’s parking lot.

    Her parents, Amy and Tom Forchas, said in a statement that they were overwhelmed with gratitude for the medical professionals who saved their daughter’s life. They described her return home Thursday as “one of the most extraordinary days of our lives.”

    Her healing journey will continue with outpatient therapy, and she still has a long road to recovery ahead, her parents said, adding that they’ve been excited to witness daily improvements in her speech, her ability to walk and “her personality shining through once more.”

    Another child who had a traumatic brain injury from the shooting, Lydia Kaiser, 12, was similarly celebrated as she returned to school last week, according to an online fundraising page started to support her family. Kaiser also underwent surgeries to remove a bullet fragment and alleviate pressure inside her head.

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  • Bon Jovi is hitting the road. Band announces first tour since Jon Bon Jovi’s vocal cord surgery

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    NEW YORK — NEW YORK (AP) — Decades into his career and the unthinkable happened. It was 2022, and Jon Bon Jovi began struggling through his songs. He saw a doctor who said one of his vocal cords was atrophying. He needed major surgery.

    Bon Jovi had the procedure, and in the years since, has undergone extensive rehab, leading to the current moment: Next summer his band, Bon Jovi, will embark on their first tour in four years.

    The “Forever Tour” kicks off with four nights at New York’s Madison Square Garden before the band heads to Edinburgh, Scotland; Dublin and London.

    “There is a lot of joy in this announcement — joy that we can share these nights together with our amazing fans and joy that the band can be together,” Bon Jovi said in a statement. “I’ve spoken extensively on my gratitude but I will say it again, I’m deeply grateful that the fans and the brotherhood of this band have been patient and allowed me the time needed to get healthy and prepare for touring. I’m ready and excited!”

    Bon Jovi’s last concert was held on April 30, 2022, in Nashville — as seen in the 2024 Hulu documentary, “Thank You, Goodnight: The Bon Jovi Story.”

    An artist presale begins Tuesday at 10 a.m. Eastern. General sales launch Oct. 31, also at 10 a.m. Eastern, via bonjovi.com.

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  • Bon Jovi Is Hitting the Road. Band Announces First Tour Since Jon Bon Jovi’s Vocal Cord Surgery

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    NEW YORK (AP) — Decades into his career and the unthinkable happened. It was 2022, and Jon Bon Jovi began struggling through his songs. He saw a doctor who said one of his vocal cords was atrophying. He needed major surgery.

    Bon Jovi had the procedure, and in the years since, has undergone extensive rehab, leading to the current moment: Next summer his band, Bon Jovi, will embark on their first tour in four years.

    The “Forever Tour” kicks off with four nights at New York’s Madison Square Garden before the band heads to Edinburgh, Scotland; Dublin and London.

    “There is a lot of joy in this announcement — joy that we can share these nights together with our amazing fans and joy that the band can be together,” Bon Jovi said in a statement. “I’ve spoken extensively on my gratitude but I will say it again, I’m deeply grateful that the fans and the brotherhood of this band have been patient and allowed me the time needed to get healthy and prepare for touring. I’m ready and excited!”

    Bon Jovi’s last concert was held on April 30, 2022, in Nashville — as seen in the 2024 Hulu documentary, “Thank You, Goodnight: The Bon Jovi Story.”

    An artist presale begins Tuesday at 10 a.m. Eastern. General sales launch Oct. 31, also at 10 a.m. Eastern, via bonjovi.com.

    Copyright 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

    Photos You Should See – Oct. 2025

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  • Music Could Help Ease Pain from Surgery or Illness. Scientists are Listening

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    Nurse Rod Salaysay works with all kinds of instruments in the hospital: a thermometer, a stethoscope and sometimes his guitar and ukulele.

    In the recovery unit of UC San Diego Health, Salaysay helps patients manage pain after surgery. Along with medications, he offers tunes on request and sometimes sings. His repertoire ranges from folk songs in English and Spanish to Minuet in G Major and movie favorites like “Somewhere Over the Rainbow.”

    Patients often smile or nod along. Salaysay even sees changes in their vital signs like lower heart rate and blood pressure, and some may request fewer painkillers.

    “There’s often a cycle of worry, pain, anxiety in a hospital,” he said, “but you can help break that cycle with music.”

    Salaysay is a one-man band, but he’s not alone. Over the past two decades, live performances and recorded music have flowed into hospitals and doctors’ offices as research grows on how songs can help ease pain.

    Scientists explore how music affects pain perception

    The healing power of song may sound intuitive given music’s deep roots in human culture. But the science of whether and how music dulls acute and chronic pain — technically called music-induced analgesia — is just catching up.

    No one suggests that a catchy song can fully eliminate serious pain. But several recent studies, including in the journals Pain and Scientific Reports, have suggested that listening to music can either reduce the perception of pain or enhance a person’s ability to tolerate it.

    What seems to matter most is that patients — or their families — choose the music selections themselves and listen intently, not just as background noise.

    How music can affect pain levels

    “Pain is a really complex experience,” said Adam Hanley, a psychologist at Florida State University. “It’s created by a physical sensation, and by our thoughts about that sensation and emotional reaction to it.”

    Two people with the same condition or injury may feel vastly different levels of acute or chronic pain. Or the same person might experience pain differently from one day to the next.

    Acute pain is felt when pain receptors in a specific part of the body — like a hand touching a hot stove — send signals to the brain, which processes the short-term pain. Chronic pain usually involves long-term structural or other changes to the brain, which heighten overall sensitivity to pain signals. Researchers are still investigating how this occurs.

    “Pain is interpreted and translated by the brain,” which may ratchet the signal up or down, said Dr. Gilbert Chandler, a specialist in chronic spinal pain at the Tallahassee Orthopedic Clinic.

    Researchers know music can draw attention away from pain, lessening the sensation. But studies also suggest that listening to preferred music helps dull pain more than listening to podcasts.

    “Music is a distractor. It draws your focus away from the pain. But it’s doing more than that,” said Caroline Palmer, a psychologist at McGill University who studies music and pain.

    Scientists are still tracing the various neural pathways at work, said Palmer.

    “We know that almost all of the brain becomes active when we engage in music,” said Kate Richards Geller, a registered music therapist in Los Angeles. “That changes the perception and experience of pain — and the isolation and anxiety of pain.”

    Music genres and active listening

    The idea of using recorded music to lessen pain associated with dental surgery began in the late 19th century before local anesthetics were available. Today researchers are studying what conditions make music most effective.

    Researchers at Erasmus University Rotterdam in the Netherlands conducted a study on 548 participants to see how listening to five genres of music — classical, rock, pop, urban and electronic — extended their ability to withstand acute pain, as measured by exposure to very cold temperatures.

    All music helped, but there was no single winning genre.

    “The more people listened to a favorite genre, the more they could endure pain,” said co-author Dr. Emy van der Valk Bouman. “A lot of people thought that classical music would help them more. Actually, we are finding more evidence that what’s best is just the music you like.”

    The exact reasons are still unclear, but it may be because familiar songs activate more memories and emotions, she said.

    The simple act of choosing is itself powerful, said Claire Howlin, director of the Music and Health Psychology Lab at Trinity College Dublin, who co-authored a study that suggested allowing patients to select songs improved their pain tolerance.

    “It’s one thing that people can have control over if they have a chronic condition — it gives them agency,” she said.

    Active, focused listening also seems to matter.

    Hanley, the Florida State psychologist, co-authored a preliminary study suggesting daily attentive listening might reduce chronic pain.

    “Music has a way of lighting up different parts of the brain,” he said, “so you’re giving people this positive emotional bump that takes their mind away from the pain.”

    It’s a simple prescription with no side effects, some doctors now say.

    Cecily Gardner, a jazz singer in Culver City, California, said she used music to help get through a serious illness and has sung to friends battling pain.

    “Music reduces stress, fosters community,” she said, “and just transports you to a better place.”

    Copyright 2025. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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  • Music could help ease pain from surgery or illness. Scientists are listening

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    Nurse Rod Salaysay works with all kinds of instruments in the hospital: a thermometer, a stethoscope and sometimes his guitar and ukulele.

    In the recovery unit of UC San Diego Health, Salaysay helps patients manage pain after surgery. Along with medications, he offers tunes on request and sometimes sings. His repertoire ranges from folk songs in English and Spanish to Minuet in G Major and movie favorites like “Somewhere Over the Rainbow.”

    Patients often smile or nod along. Salaysay even sees changes in their vital signs like lower heart rate and blood pressure, and some may request fewer painkillers.

    “There’s often a cycle of worry, pain, anxiety in a hospital,” he said, “but you can help break that cycle with music.”

    Salaysay is a one-man band, but he’s not alone. Over the past two decades, live performances and recorded music have flowed into hospitals and doctors’ offices as research grows on how songs can help ease pain.

    The healing power of song may sound intuitive given music’s deep roots in human culture. But the science of whether and how music dulls acute and chronic pain — technically called music-induced analgesia — is just catching up.

    No one suggests that a catchy song can fully eliminate serious pain. But several recent studies, including in the journals Pain and Scientific Reports, have suggested that listening to music can either reduce the perception of pain or enhance a person’s ability to tolerate it.

    What seems to matter most is that patients — or their families — choose the music selections themselves and listen intently, not just as background noise.

    “Pain is a really complex experience,” said Adam Hanley, a psychologist at Florida State University. “It’s created by a physical sensation, and by our thoughts about that sensation and emotional reaction to it.”

    Two people with the same condition or injury may feel vastly different levels of acute or chronic pain. Or the same person might experience pain differently from one day to the next.

    Acute pain is felt when pain receptors in a specific part of the body — like a hand touching a hot stove — send signals to the brain, which processes the short-term pain. Chronic pain usually involves long-term structural or other changes to the brain, which heighten overall sensitivity to pain signals. Researchers are still investigating how this occurs.

    “Pain is interpreted and translated by the brain,” which may ratchet the signal up or down, said Dr. Gilbert Chandler, a specialist in chronic spinal pain at the Tallahassee Orthopedic Clinic.

    Researchers know music can draw attention away from pain, lessening the sensation. But studies also suggest that listening to preferred music helps dull pain more than listening to podcasts.

    “Music is a distractor. It draws your focus away from the pain. But it’s doing more than that,” said Caroline Palmer, a psychologist at McGill University who studies music and pain.

    Scientists are still tracing the various neural pathways at work, said Palmer.

    “We know that almost all of the brain becomes active when we engage in music,” said Kate Richards Geller, a registered music therapist in Los Angeles. “That changes the perception and experience of pain — and the isolation and anxiety of pain.”

    The idea of using recorded music to lessen pain associated with dental surgery began in the late 19th century before local anesthetics were available. Today researchers are studying what conditions make music most effective.

    Researchers at Erasmus University Rotterdam in the Netherlands conducted a study on 548 participants to see how listening to five genres of music — classical, rock, pop, urban and electronic — extended their ability to withstand acute pain, as measured by exposure to very cold temperatures.

    All music helped, but there was no single winning genre.

    “The more people listened to a favorite genre, the more they could endure pain,” said co-author Dr. Emy van der Valk Bouman. “A lot of people thought that classical music would help them more. Actually, we are finding more evidence that what’s best is just the music you like.”

    The exact reasons are still unclear, but it may be because familiar songs activate more memories and emotions, she said.

    The simple act of choosing is itself powerful, said Claire Howlin, director of the Music and Health Psychology Lab at Trinity College Dublin, who co-authored a study that suggested allowing patients to select songs improved their pain tolerance.

    “It’s one thing that people can have control over if they have a chronic condition — it gives them agency,” she said.

    Active, focused listening also seems to matter.

    Hanley, the Florida State psychologist, co-authored a preliminary study suggesting daily attentive listening might reduce chronic pain.

    “Music has a way of lighting up different parts of the brain,” he said, “so you’re giving people this positive emotional bump that takes their mind away from the pain.”

    It’s a simple prescription with no side effects, some doctors now say.

    Cecily Gardner, a jazz singer in Culver City, California, said she used music to help get through a serious illness and has sung to friends battling pain.

    “Music reduces stress, fosters community,” she said, “and just transports you to a better place.”

    ___

    The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

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  • Music Could Help Ease Pain From Surgery or Illness. Scientists Are Listening

    [ad_1]

    Nurse Rod Salaysay works with all kinds of instruments in the hospital: a thermometer, a stethoscope and sometimes his guitar and ukulele.

    In the recovery unit of UC San Diego Health, Salaysay helps patients manage pain after surgery. Along with medications, he offers tunes on request and sometimes sings. His repertoire ranges from folk songs in English and Spanish to Minuet in G Major and movie favorites like “Somewhere Over the Rainbow.”

    Patients often smile or nod along. Salaysay even sees changes in their vital signs like lower heart rate and blood pressure, and some may request fewer painkillers.

    “There’s often a cycle of worry, pain, anxiety in a hospital,” he said, “but you can help break that cycle with music.”

    Salaysay is a one-man band, but he’s not alone. Over the past two decades, live performances and recorded music have flowed into hospitals and doctors’ offices as research grows on how songs can help ease pain.


    Scientists explore how music affects pain perception

    The healing power of song may sound intuitive given music’s deep roots in human culture. But the science of whether and how music dulls acute and chronic pain — technically called music-induced analgesia — is just catching up.

    No one suggests that a catchy song can fully eliminate serious pain. But several recent studies, including in the journals Pain and Scientific Reports, have suggested that listening to music can either reduce the perception of pain or enhance a person’s ability to tolerate it.

    What seems to matter most is that patients — or their families — choose the music selections themselves and listen intently, not just as background noise.


    How music can affect pain levels

    “Pain is a really complex experience,” said Adam Hanley, a psychologist at Florida State University. “It’s created by a physical sensation, and by our thoughts about that sensation and emotional reaction to it.”

    Two people with the same condition or injury may feel vastly different levels of acute or chronic pain. Or the same person might experience pain differently from one day to the next.

    Acute pain is felt when pain receptors in a specific part of the body — like a hand touching a hot stove — send signals to the brain, which processes the short-term pain. Chronic pain usually involves long-term structural or other changes to the brain, which heighten overall sensitivity to pain signals. Researchers are still investigating how this occurs.

    “Pain is interpreted and translated by the brain,” which may ratchet the signal up or down, said Dr. Gilbert Chandler, a specialist in chronic spinal pain at the Tallahassee Orthopedic Clinic.

    Researchers know music can draw attention away from pain, lessening the sensation. But studies also suggest that listening to preferred music helps dull pain more than listening to podcasts.

    “Music is a distractor. It draws your focus away from the pain. But it’s doing more than that,” said Caroline Palmer, a psychologist at McGill University who studies music and pain.

    Scientists are still tracing the various neural pathways at work, said Palmer.

    “We know that almost all of the brain becomes active when we engage in music,” said Kate Richards Geller, a registered music therapist in Los Angeles. “That changes the perception and experience of pain — and the isolation and anxiety of pain.”


    Music genres and active listening

    The idea of using recorded music to lessen pain associated with dental surgery began in the late 19th century before local anesthetics were available. Today researchers are studying what conditions make music most effective.

    Researchers at Erasmus University Rotterdam in the Netherlands conducted a study on 548 participants to see how listening to five genres of music — classical, rock, pop, urban and electronic — extended their ability to withstand acute pain, as measured by exposure to very cold temperatures.

    All music helped, but there was no single winning genre.

    “The more people listened to a favorite genre, the more they could endure pain,” said co-author Dr. Emy van der Valk Bouman. “A lot of people thought that classical music would help them more. Actually, we are finding more evidence that what’s best is just the music you like.”

    The exact reasons are still unclear, but it may be because familiar songs activate more memories and emotions, she said.

    The simple act of choosing is itself powerful, said Claire Howlin, director of the Music and Health Psychology Lab at Trinity College Dublin, who co-authored a study that suggested allowing patients to select songs improved their pain tolerance.

    “It’s one thing that people can have control over if they have a chronic condition — it gives them agency,” she said.

    Active, focused listening also seems to matter.

    Hanley, the Florida State psychologist, co-authored a preliminary study suggesting daily attentive listening might reduce chronic pain.

    “Music has a way of lighting up different parts of the brain,” he said, “so you’re giving people this positive emotional bump that takes their mind away from the pain.”

    It’s a simple prescription with no side effects, some doctors now say.

    Cecily Gardner, a jazz singer in Culver City, California, said she used music to help get through a serious illness and has sung to friends battling pain.

    “Music reduces stress, fosters community,” she said, “and just transports you to a better place.”

    The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

    Copyright 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

    Photos You Should See – Oct. 2025

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  • 2025-26 NBA preview: Southwest Division capsules

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    (Photo credit: Lucas Peltier-Imagn Images)

    Southwest Division team capsules

    1. Houston Rockets

    2024-25 record: 52-30, 1st in the Southwest

    Head coach: Ime Udoka, third season with the Rockets (93-71 record)

    Coming and going: The Rockets made the most significant move of the offseason by trading for Kevin Durant in July. The deal cost them Jalen Green and Dillon Brooks (as well as draft choices).

    Numbers to crunch: The Rockets were middle of the pack in scoring (14th, 114.3 points per game) last season, which is one of many reasons the Durant acquisition makes sense.

    Season snapshot: The Rockets were a playoff bust last season, losing to the seventh-seeded Warriors in seven games in the first round. The acquisition of Durant should at a minimum ensure a longer stay in the playoffs. Durant averaged 26.6 points per game last season and turned 37 in September.Having Durant and fellow newcomers Clint Capela, Dorian Finney-Smith and Josh Okogie join holdovers Alperen Sengun, All-Defensive First Team selection Amen Thompson, Jabari Smith Jr., Tari Eason and Reed Sheppard should make Houston a repeat division champion and a threat to unseat Oklahoma City in the Western Conference. The loss of Fred VanVleet (ACL) hurts for countless reasons, from perimeter shooting to leadership and valuing the ball. A move to upgrade at the position might become necessary.2. Dallas Mavericks

    2024-25 record: 39-43, 3rd in the Southwest

    Head coach: Jason Kidd, fifth season with the Mavericks (179-149 record)

    Coming and going : The selection of forward Cooper Flagg with the No. 1 overall draft pick and the signing of veteran point guard D’Angelo Russell changed Dallas’ identity in a hurry.

    Numbers to crunch: Only six NBA teams averaged fewer than Dallas’ 25.2 assists last season. Russell, Kyrie Irving and Flagg, who might start the season at point guard, should improve that ranking.

    Season snapshot: Last season the Mavericks barely got into the play-in tournament and didn’t advance out of it just a year after reaching the NBA Finals. Life without Luka Doncic looked liked it would be difficult for a while.But Flagg, Anthony Davis leading a deep veteran frontcourt and the return of Irving from knee surgery at some point to join Klay Thompson in the backcourt will mark the beginning of a very bright new future that should include a return to the playoffs.3. Memphis Grizzlies

    2024-25 record: 48-34, 2nd in the Southwest

    Head coach: Tuomas Iisalo, first full season with the Grizzlies (4-5 record as interim head coach)

    Coming and going: The trading of Desmond Bane to Orlando leaves Memphis without one of its primary scorers, though they did bring in veteran Kentavious Caldwell-Pope as part of the deal.

    Numbers to crunch: The Grizzlies averaged 121.7 points last season (second to Oklahoma City), but this year’s team figures to be a lower-scoring group.

    Season snapshot: Things were looking good for much of last season before a late-season slide led to the firing of head coach Taylor Jenkins with just weeks left in the regular season, which was followed by being swept by Oklahoma City in the first round of the playoffs.The presence of Ja Morant and Jaren Jackson Jr., who is the primary complement to Morant, will keep the Grizzlies relevant. But it’s difficult not to see a drop-off in Bane’s absence, though the arrival of first-round pick Cedric Coward should help.4. San Antonio Spurs

    2024-25 record: 34-48, 4th in the Southwest

    Head coach: Mitch Johnson, first full season with the Spurs (32-45 record as interim head coach)

    Coming and going: The drafting of Dylan Harper (No. 2 overall) and Carter Bryant (No. 14 overall) as well as the signing of Luke Kornet upgrades the cast around Victor Wembanyama as he enters his third season.

    Numbers to crunch: San Antonio tied for 18th in the NBA with an average of 43.7 rebounds per game last season and the arrival of Kornet should help the Spurs become a better rebounding team.

    Season snapshot: San Antonio continues to ascend with a mostly young roster. Having De’Aaron Fox for a full season to lead a cast featuring Wembanyama, Harrison Barnes and emerging players such as Devin Vassell, reigning Rookie of the Year Stephon Castle, Keldon Johnson and Jeremy Sochan have the team on the fast track to a return to the playoffs.How much Johnson grows as a young head coach and how well the team adjusts to knowing the Gregg Popovich coaching era is officially over will determine whether that return happens as soon as this season.5. New Orleans Pelicans

    2024-25 record: 21-61, 5th in the Southwest

    Head coach: Willie Green, fifth season with the Pelicans (148-180 record)

    Coming and going: New chief executive Joe Dumars rebuilt the roster with the acquisition of veterans Jordan Poole, Saddiq Bey and Kevon Looney as well as lottery picks Jeremiah Fears and Derik Queen. The trade with Washington for Poole and Bey cost them guard CJ McCollum, a team leader.

    Numbers to crunch: Injuries forced New Orleans to use 47 starting lineups, second-most in the NBA last season. Staying healthy has been a yearly problem.

    Season snapshot: The Pelicans’ fortunes always rest on the availability of two-time All-Star forward Zion Williamson, who has missed more games (258) due to injuries than he has played in (214) since being the No. 1 overall draft pick in 2019.Two years ago he played in a career-high 70 games and New Orleans matched its second-best record in franchise history. Last season he played in 30 games and the team had its second-fewest wins. If Dejounte Murray has a successful mid-season return from Achilles surgery and the young core stays mostly healthy, a play-in tournament berth could be within the Pelicans’ reach.–Field Level Media

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  • Yankees’ Aaron Judge Doesn’t Need Surgery, Volpe and Rodón Had Operations and Could Miss Opening Day

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    NEW YORK (AP) — Yankees star Aaron Judge won’t need surgery on his elbow but shortstop Anthony Volpe and left-hander Carlos Rodón had operations this week and could miss opening day.

    Judge’s throwing was limited after he hurt the flexor tendon in his right elbow in July. Manager Aaron Boone said Thursday an MRI after the team was eliminated last week showed “no surgery is going to be needed.”

    Volpe had surgery Tuesday with Dr. Christopher Ahmad to repair the labrum in his left shoulder. Boone said he can start hitting in four months but can’t dive on it for six months.

    Rodón was operated on by Dr. Neal ElAttrache to remove loose bodies in his left elbow and shave a bone spur. He has eight weeks of no throwing and the start of his season could be delayed by a couple of weeks, Boone said.

    Boone said Giancarlo Stanton does not need surgery on his elbows and Gerrit Cole, returning from Tommy John surgery in March, will throw lightly off a mound next week and could be available not far after opening day.

    He also said bullpen coach Mike Harkey and first base/infield coach Travis Chapman won’t return for 2026 and assistant hitting coach Pat Roessler won’t return in that role.

    Judge led the major leagues with a .331 average and 1.145 OPS, hitting 53 homers with 114 RBIs and 124 walks. He hit .500 with one homer, seven RBIs and four walks in the postseason as the Yankees were eliminated by Toronto in an AL Division Series.

    Volpe hurt the shoulder on May 3 in an unsuccessful attempt for a backhand stab on Christopher Morel’s eighth-inning single, which sparked a two-run rally in Tampa Bay’s 3-2 win. He returned to the lineup two days later but struggled for much of the season.

    Volpe, 24, had a cortisone shot during the All-Star break and a second one on Sept. 10, three days after aggravating the shoulder while making a diving stop on Isiah Kiner-Falefa in a 4-3 win over Toronto. Volpe hit .212 with 19 homers and a career-high 72 RBIs and then .192 with one homer, two RBIs and 16 strikeouts in seven postseason games. He went 1 for 15 with 11 strikeouts in the AL Division Series, making out in his last 13 at-bats.

    In the field, Volpe made a career-high 19 errors, tied for third-most among major league shortstops.

    Rodón, who turns 33 in December, was 18-9 with a 3.09 ERA.

    Copyright 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

    Photos You Should See – Oct. 2025

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  • J&J Lays Out Plan to Splinter Orthopedics Business Into Separate Company

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    The health care giant said Tuesday that it will separate its orthopedics business into a standalone company known as DePuy Synthes. The move leaves J&J focused on its pharmaceutical and MedTech segments, which make prescription drugs, contact lenses and technology to treat cardiovascular disease and help with surgeries.

    The orthopedics business will be led by Namal Nawana, a former CEO of the medical technology business Smith & Nephew, which makes products for sports medicine and wound management and also focuses on orthopedics.

    J&J’s orthopedics business pulled in more than $9 billion in sales last year. But the company said the split will help it focus on higher-growth areas.

    The company expects to complete the move over the next 18 to 24 months.

    J&J announced in November, 2021, that it would turn its consumer health business, which makes Band-Aids, Listerine and Tylenol into a separate company that later became known as Kenvue.

    New Brunswick, New Jersey-based Johnson & Johnson also reported on Tuesday better-than-expected third-quarter earnings and reaffirmed its adjusted earnings guidance for the year.

    Company shares slipped more than $2 to $188.74 in premarket trading. The shares have already climbed more than 30% so far this year.

    Copyright 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

    Photos You Should See – Oct. 2025

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  • Biden Is Receiving Radiation and Hormone Therapy to Treat His Prostate Cancer

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    WASHINGTON (AP) — Former President Joe Biden is receiving radiation and hormone therapy as part of a new phase of treating the aggressive form of prostate cancer he was diagnosed with after leaving office, a spokesperson said Saturday.

    “As part of a treatment plan for prostate cancer, President Biden is currently undergoing radiation therapy and hormone treatment,” said Biden aide Kelly Scully.

    In May, Biden’s postpresidential office announced that he had been diagnosed with prostate cancer and that it had spread to his bone. The discovery came after he reported urinary symptoms.

    Prostate cancers are graded for aggressiveness using what is known as a Gleason score. The scores range from 6 to 10, with 8, 9 and 10 prostate cancers behaving more aggressively. Biden’s office said his score was 9, suggesting his cancer is among the most aggressive.

    Copyright 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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  • Rolando Villazón directs opera at the world’s top houses while still singing

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    NEW YORK — NEW YORK (AP) — Tenor Rolando Villazón was singing the title role in Massenet’s “Werther” in 2006 at Nice, France, when he started thinking about how he would direct the opera.

    “I said, ‘oh, this last act is very difficult. He shot himself and keeps singing for 40 minutes.’ And so, what would I do?” he recalled. “And I started inventing, creating for fun a staging.”

    Nearly two decades later, Villazón is making his Metropolitan Opera directing debut in Bellini’s “La Sonnambula,” which opened Monday night with a standout cast of Nadine Sierra, Xabier Anduaga and Alexander Vinogradov.

    “He is very sensitive to singers,” Sierra said. “Maybe some directors, because they’re not singers or they were never singers, it’s hard for them to really relate to the psychological struggle that some singers, we deal with on stage. We want to make our characters as believable as humanly possible through the actions that we show, but sometimes it’s hard to do that because you also have to sing high notes.”

    Villazón grew up in Mexico City, won Plácido Domingo’s Operalia competition in 1999 and made his European debut that year in Massenet’s “Manon” at Genoa, Italy. He debuted at the Met in Verdi’s “La Traviata” in 2003 and gained wide renown when he sang Alfredo with Anna Netrebko’s Violetta in Willy Decker’s austere staging at the 2005 Salzburg Festival.

    Vocal problems developed in 2007, causing Villazón to cancel his schedule, and he had surgery in 2009 to remove a cyst from his vocal cords. He developed performance anxiety around 2015 and had another operation in 2018 to relieve acid reflux.

    “Two things coincided when I stopped singing for a year in 2009 — and that was I wrote my first novel and I prepared my staging, but both didn’t happen because I was resting,” he said. “Would I have finished my novel? I don’t know. But stage direction for sure that would have happened.”

    When Villazón conceived his “Werther” staging, he shared it with Alain Lanceron, then head of the tenor’s record label, Virgin Classics. Richard Jones, a director Villazón had worked with, helped him find a theater. After being turned down in Berlin, Villazón won over Serge Dorny, then general director in Lyon and now head of the Bavarian State Opéra.

    Villazón’s “Werther” debuted in 2011, and he directed Donizetti’s “L’Elisir d’Amore” the following year at Baden-Baden, Germany, while also singing Nemorino.

    He has gone on to direct Verdi’s “La Traviata,” Donizetti’s “Don Pasquale,” Strauss’s “Die Fledermaus,” Rameau’s “Platée,” Bellini’s “I Puritani” and Rossini’s “Il Barbiere di Siviglia,” and has upcoming productions of Mozart’s “ Die Zauberflöte” and Rossini’s “L’Italiana in Algeri.”

    His “Sonnambula” unfolds in an icy Alp village within a single set in front of projections and was first seen at Paris’ Théâtre des Champs-Elysées in 2021, then at Nice in 2022 and Dresden, Germany, in 2023. It was to have traveled to the Met in 2023-24 but was postponed because of budget cuts.

    “In the staging rehearsals, he was always on the stage with them,” Met general manager Peter Gelb said. “Usually, directors are in the room with the singers, but they spend a lot of the time watching from a distant seat. He was more in the trenches with the singers than most directors are.”

    Villazón rejects the happy ending of Donizetti and librettist Felice Romani. Rather than Amina awakening from sleepwalking in ecstasy when she learns Elvino will marry her, she gives him back his ring and runs off to an independent future. He tweaked the direction for New York, cutting the dancing spirits Amina hallucinates from three to one and adding a globe, a telescope and a newspaper as gifts from Count Rodolfo to show the worldly curiosity she seeks.

    “It remains in essence the concept I had thought for it, the concept of a closed society, patriarchal, for sure very religious, where there is a strange woman adopted by a widow,” Villazón said. “She is obliged to follow the rules and to adapt to the way the community behaves for the good of the community, but she still feels this call of the wild.”

    Sierra and Anduaga had sung these roles in a Barbara Llutch staging that opened in Madrid in December 2022 and traveled to Barcelona last April before coming to New York to work with Villazón,

    “He really understands our situation,” Anduaga said. “He doesn’t want to to do anything weird or strange with the body because he knows that all the movements are important, but the singing is the most important thing.”

    Villazón learned from his experience with a string of top directors, including Decker, Jones, Robert Carsen, Claus Guth, Christof Loy and Bart Sher.

    “Richard Jones told me: `You ask something three times,’” Villazón recalled. ”`If the performer doesn’t do it, either he or she is unable to do it or incapable to do it. In either case, you will not get what you’re asking, so move on and think of something else.’”

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  • Jets running back Braelon Allen likely out 8 to 12 weeks with knee injury

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    FLORHAM PARK, N.J. — FLORHAM PARK, N.J. (AP) — New York Jets running back Braelon Allen will likely be out between eight and 12 weeks with a knee injury that landed him on injured reserve this week, coach Aaron Glenn said Friday.

    Allen was hurt while returning a kickoff last Monday night in the Jets’ 27-21 loss to the Dolphins in Miami. The team hasn’t specified the exact nature of the injury, but it’s believed to be to the MCL in his left knee.

    Glenn said Allen, in his second season with the Jets, was still contemplating his next step in his recovery.

    “There’s two different ways he can go about it,” Glenn said. “He could actually rehab this. It’ll be the same time frame or he could have surgery and get it cleaned up. But the rehab time will be exactly the same. So, that will be a decision him and his agent will have to make. I’m not making that decision for him.”

    With an 8-to-12 week timetable, that would keep Allen sidelined until at least December.

    “So, we know it’s going to be a significant amount of time,” Glenn said. “But again, that’ll be his decision on how he wants to go about that and I know he’ll make the right decision for himself.”

    The 21-year-old Allen, a fourth-rounder last year out of Wisconsin, rushed for 334 yards and two touchdowns as a rookie and caught 19 passes for 148 yards and a score. This season, he has 76 yards and a TD on 18 carries, along with two catches for 17 yards.

    Breece Hall remains the Jets’ No. 1 running back, but Isaiah Davis will move up into Allen’s backup spot for the game Sunday against Dallas. The Jets also signed veteran Khalil Herbert off Seattle’s practice squad on Thursday to add depth and experience.

    “I remember him and D-Mo — David Montgomery, who the Lions have right now — and going against both of those guys,” Glenn recalled of the running backs’ time in Chicago when he was Detroit’s defensive coordinator. “It’s funny because I just told him this today that we thought he was just as good as David was.”

    The 27-year-old Herbert has rushed for 1,905 yards and nine touchdowns and caught 53 passes for 312 yards and two scores in his career that also has included stops with Cincinnati and Indianapolis.

    “I’m happy we got this player,” Glenn said. “He still has a lot of meat on the bone left. And with the injuries we’ve had, to get a player like this was critical for us.”

    New York also signed former Falcons and Eagles running back and kick returner Avery Williams to the practice squad. The Jets are hoping to get running back Kene Nwangwu, their primary kick returner, back from an injured hamstring but Williams gives them some depth.

    Glenn ruled out nickel cornerback Michael Carter II, who remained in the concussion protocol after getting injured in Miami. Recently acquired Jarvis Brownlee Jr. could make his debut for New York and fill in for Carter.

    A decision on edge rusher Jermaine Johnson’s return from a calf injury could “come down to the wire,” Glenn said. Johnson, who has missed the last two games, posted an optimistic update on X: “I feel great.”

    ___

    AP NFL: https://apnews.com/hub/NFL

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  • IBD and Cannabis  | NutritionFacts.org

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    Smoking cannabis may help with symptoms of inflammatory bowel disease (IBD) in the short term, but it may make the long-term prognosis worse.

    As this study asks, “Medical Marijuana: A Panacea or Scourge?” For 5,000 years, cannabis “has been used throughout the world medically, recreationally, and spiritually.” It was even prescribed by American physicians “for a plethora of indications” from the mid-19th century to the 1930s, a fact that’s often used by medical marijuana proponents as evidence justifying the modern medical applications.” But the field of old-timey medicine is “fraught with potions and herbal remedies,” not to mention bloodletting and other questionable and harmful remedies.

    Skeptics criticize the medical marijuana movement as the “‘medical excuse marijuana’ movement,” insinuating that children with epilepsy and the terminally ill are being “used as a ‘Trojan horse’ for the legalization of recreational cannabis use” or to peddle “outlandish claims” about “miracle cancer cures,” frustrating researchers in the field who just want to get at the science.

    For example, what about the therapeutic use of cannabis for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis? Conventional therapies work mainly by suppressing the immune system to try to tamp down inflammation. “Given the limited therapy options and known adverse side effects with chronic use” from these drugs, people suffering from these diseases often need to have inflamed sections of their bowels removed surgically, so it’s clear why there’s so much interest in alternative approaches.

    About one in six IBD patients who use marijuana say it helps with their symptoms, so researchers decided to put it to the test. Thirteen patients with IBD were given a third of a pound of marijuana to smoke at their leisure over a period of three months, and they reported feeling significantly better with “reported improvement in general health perception, social functioning, ability to work, physical pain, and depression.” There wasn’t a control group, so it’s unknown if they would have improved anyway or what role the placebo effect may have played. It’s like some of the studies of cannabis used for pediatric epilepsy that had response rates exceeding 30 percent and a frequency cut in half in a third of the kids. Amazing results until you realize you can sometimes get similarly amazing responses from giving kids nothing but a sugar pill placebo, as seen below and at 2:21 in my video Friday Favorites: Cannabis for Inflammatory Bowel Disease (IBD). That’s why it’s critical to do randomized, double-blind, placebo-controlled trials, but there weren’t any on cannabis and IBD until 2013. 

    For 21 patients with Crohn’s disease, nothing seemed to help. So researchers randomized them to either smoke two joints a day of marijuana or a look-alike placebo. The results? Ninety percent of those in the cannabis group got better, compared to only 40 percent in the placebo group. Shown below and at 3:11 in my video is a graph of their symptom scores. As you can see, there was no big change in the placebo group over the two-month study, but the cannabis group cut their symptoms by about half. 

    The researchers acknowledge that long-term cannabis use is not without risks, but it may be a cakewalk compared to the potential adverse—and even life-threatening—side effects of some of the more powerful conventional therapies, so the study was heralded in a paper entitled “High Hope for Medical Marijuana in Digestive Disorders.”

    The study was funded by a medical marijuana advocacy organization, the main supplier in the country, in fact. So, expectations may have been placed on the participants about how much better they would feel—in other words, they may have been primed for the placebo effect. But the researchers controlled for that, right? Those getting the real cannabis did significantly better than those randomized to get the placebo. But the point of a placebo is that it is indistinguishable from the real thing, so the participants don’t know which group they’re in—the control group or the treatment group. How can that be accomplished with a psychoactive drug? It can’t, which is the problem. The researchers tried to hide which group participants were in by only recruiting patients who had never tried cannabis before in the hopes that they wouldn’t notice placebo pot, but, unsurprisingly, most of them did. So, we’re basically left with another unblinded study. The researchers asked a bunch of subjective questions, like “How are you feeling?” and those who pretty much knew they were taking the drug said they were feeling better.

    There were no significant changes in objective lab values, like CRP, a sign of inflammation, so perhaps the “cannabis may simply be masking symptoms without affecting intestinal inflammation.” Another indicator that it may not be affecting the course of the disease itself is how quickly the symptoms rebound. Two weeks after the study ended, those in the cannabis group were right back to where they started, as shown here (see week 10) and at 5:05 in my video

    So, “there was no difference in objective inflammatory markers to indicate disease modification. Given the rapid rebound…to pretreatment levels after the 2-week washout period, it seems more plausible that cannabis ameliorated the symptoms of Crohn’s disease, rather than actually modulating the disease.” That may be, but the symptoms are terrible. A reduction in pain is a reduction in pain. Indeed, “from the point of view of the patients, a marked symptomatic improvement and ability to resume normal life is not trivial, even if inflammation persists.” Of course, what if cannabis somehow makes the disease worse in the long run?

    A survey study published the following year found that cannabis provided the same immediate symptomatic relief but was associated with a worse disease prognosis over time. Patients with IBD reported that cannabis improved their pain, cramping, and diarrhea, but use for more than six months by Crohn’s patients appeared to be a strong predictor of them ending up in surgery; they had five times the odds of going under the knife. There are two possible explanations for this: It’s quite possible that the increased disease severity led to the cannabis use and not the other way around. The alternative explanation: “Cannabis use may worsen the prognosis of IBD, leading to greater surgeries and hospitalizations.”

    This is why we need prospective clinical trials where people are followed over time to see which came first. Until then, perhaps we should consider cannabis use for IBD as “potentially harmful.” Not just to err on the side of caution, but because there was a study on hepatitis C patients that found that daily cannabis use was associated with nearly seven times the odds of worse liver fibrosis, which is like scar tissue. If cannabis really does make fibrosis worse, that may explain why cannabis users with IBD may be more likely to require surgery. 

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  • Dietary Components That May Cause Cancer to Metastasize  | NutritionFacts.org

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    Palmitic acid, a saturated fat concentrated in meat and dairy, can boost the metastatic potential of cancer cells through the fat receptor CD36.

    The leading cause of death in cancer patients is metastasis formation. That’s how most people die of cancer—not from the primary tumor, but the cancer spreading through the body. “It is estimated that metastasis is responsible for ~90% of cancer deaths,” and little progress has been made in stopping the spread, despite our modern medical armamentarium. In fact, we can sometimes make matters worse. In an editorial entitled “Therapy-Induced Metastasis,” its authors “provide evidence that all the common therapies, including radiotherapy, chemotherapy, fine needle biopsies, surgical procedures and anaesthesia, have the potential to contribute to tumour progression.” You can imagine how cutting around a tumor and severing blood vessels might lead to the “migration of residual tumour cells,” but why chemotherapy? How might chemo exacerbate metastases? “Despite reducing the size of primary tumors, chemotherapy changes the tumor microenvironment”—its surrounding tissues—“resulting in an increased escape of cancer cells into the blood stream.” Sometimes, chemo, surgery, and radiation are entirely justified, but, again, other times, these treatments can make matters worse. If only we had a way to treat the cause of the cancer’s spreading.

    The development of antimetastatic therapies has been hampered by the fact that the cells that initiate metastasis remain unidentified. Then, a landmark study was published: “Targeting Metastasis-Initiating Cells Through the Fatty Acid Receptor CD36.” Researchers found a subpopulation of human cancer cells “unique in their ability to initiate metastasis”; they all express high levels of a fat receptor known as CD36, dubbed “the fat controller.” It turns out that palmitic acid or a high-fat diet specifically boosts the metastatic potential of these cancer cells. Where is palmitic acid found? Although it was originally discovered in palm oil, palmitic acid is most concentrated in meat and dairy. “Emerging evidence shows that palmitic acid (PA), a common fatty acid in the human diet, serves as a signaling molecule regulating the progression and development of many diseases at the molecular level.” It is the saturated fat that is recognized by CD36 receptors on cancer cells, and we know it is to blame, because if the CD36 receptor is blocked, so are metastases.

    The study was of a human cancer, but it was a human cancer implanted into mice. However, clinically (meaning in cancer patients themselves), the presence of these CD36-studded metastasis-initiating cells does indeed correlate with a poor prognosis. CD36 appears to drive the progression of brain tumors, for example. As seen in the survival curves shown below and at 3:21 in my video What Causes Cancer to Metastasize?, those with tumors with less CD36 expression lived significantly longer. It is the same with breast cancer mortality: “In this study, we correlated the mortality of breast cancer patients to tumor CD36 expression levels.” That isn’t a surprise, since “CD36 plays a critical role in proliferation, migration and…growth of…breast cancer cells.” If we inhibit CD36, we can inhibit “the migration and invasion of the breast cancer cells.” 

    Below and at 3:46 in my video, you can see breast cancer cell migration and invasion, before and after CD36 inhibition. (The top lines with circles are before CD36 inhibition, and the bottom lines with squares are after.)

    This isn’t only in “human melanoma- and breast cancer–derived tumours” either. Now we suspect that “CD36 expression drives ovarian cancer progression and metastasis,” too, since we can inhibit ovarian cancer cell invasion and migration, as well as block both lymph node and blood-borne metastasis, by blocking CD36. We also see the same kind of effect with prostate cancer; suppress the uptake of fat by prostate cancer cells and suppress the tumor. This was all studied with receptor-blocking drugs and antibodies in a laboratory setting, though. If these “metastasis-initiating cancer cells particularly rely on dietary lipids [fat] to promote metastasis,” the spread of cancer, why not just block the dietary fat in the first place?

    “Lipid metabolism fuels cancer’s spread.” Cancer cells love fat and cholesterol. The reason is that so much energy is stored in fat. “Hence, CD36+ metastatic cells might take advantage of this feature to obtain the high amount of energy that is likely to be required for them to anchor and survive at sites distant from the primary tumour”—to set up shop throughout the body.

    “The time when glucose [sugar] was considered as the major, if not only, fuel to support cancer cell proliferation is over.” There appears to be “a fatter way to metastasize.” No wonder high-fat diets (HFD) may “play a crucial role in increasing the risk of different cancer types, and a number of clinical studies have linked HFD with several advanced cancers.”

    If dietary fat may be “greasing the wheels of the cancer machine,” might there be “specific dietary regimens” we could use to starve cancers of dietary fat? You don’t know until you put it to the test, which we’ll look at next.

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    Michael Greger M.D. FACLM

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  • North Carolina Supreme Court orders medical certification lawsuit be reheard

    North Carolina Supreme Court orders medical certification lawsuit be reheard

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    RALEIGH, N.C. (AP) — North Carolina’s highest court ruled Friday that a lower court should reconsider the constitutionality of a state law that requires health regulators to sign off before expanded health care services can be offered to the public.

    An eye doctor originated the challenge to the series of statutes known as the certificate of need law. Dr. Jay Singleton argued the requirement that regulators approve his ability to perform surgeries at his office violates his constitutional rights.

    The state Supreme Court, in a unanimous unsigned opinion, ordered that Singleton’s case be returned to a trial court.

    The justices wrote in part that the trial court that originally heard the case and a panel on the intermediate-level Court of Appeals mistakenly treated the lawsuit as one that challenged the law solely as it related to Singleton’s situation.

    In fact, Friday’s decision read, the lawsuit also contains allegations of “facial challenges” that “if proven, could render the Certificate of Need law unconstitutional in all its applications.” That could eliminate fully the requirement that a medical entity seeking to expand bed space or use expensive equipment receive formal approval from the Department of Health and Human Services.

    The agency is supposed to determine whether the services are necessary due to things like population growth or patient needs. Republican lawmakers and right-leaning think tanks have sought to reform or do away with certificate of need, replacing them with more free-market forces.

    The facial challenge found in the lawsuit means three trial judges could now preside over the case instead of one.

    Singleton sued the state health agency and executive and legislative branch leaders in 2020, alleging he was essentially unable to expand his New Bern practice and offer less costly surgeries because state regulators have calculated there’s no need in his area for additional operating room space. Singleton had been performing most of his surgeries at a New Bern hospital.

    The ruling that vacates the 2022 Court of Appeals decision sets no date for the case to be heard.

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  • Twins born conjoined celebrate 1st birthday after separation surgery

    Twins born conjoined celebrate 1st birthday after separation surgery

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    PHILADELPHIA — Twin brothers who were born conjoined recently celebrated their first birthday after undergoing successful separation surgery.

    Amari and Javar Ruffin, whose family lives in Philadelphia, were born via cesarean section on Sept. 29, 2023. The brothers — who shared part of their sternum, diaphragm, abdominal wall and liver — weighed a combined 6 pounds.

    On Aug. 21, a surgical team at Children’s Hospital of Philadelphia with more than two dozen specialists, including surgeons, anesthesiologists, radiologists, nurses, and many others, operated for eight hours to separate the boys. Their abdomens were closed and rebuilt using layers of mesh and plastic surgery techniques.

    The boys went home on Oct. 8 to be with their parents, Tim and Shaneka, and their siblings, Kaylum and Anora.

    “Seeing them each in their own beds was an indescribable feeling,” Shaneka Ruffin said. “It feels like we are beginning a new journey as a family of six. We are so grateful to CHOP for helping make this day possible and letting us start this next chapter.”

    The Ruffins learned the twins were conjoined through a routine ultrasound 12 weeks into the pregnancy. Shaneka Ruffin said it was recommended to her that she terminate her pregnancy. They got a second opinion, and the hospital told them that though the boys had a rare condition, they could be separated successfully.

    Conjoined twins occur roughly once in every 35,000-80,000 births. The hospital is one of only a few in the U.S. with expertise in separating them.

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  • Donald Glover cancels Childish Gambino tour dates after recent surgery

    Donald Glover cancels Childish Gambino tour dates after recent surgery

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    Donald Glover has canceled the remaining dates of Childish Gambino’s North American and European tour.

    The musician, actor and “Atlanta” creator announced on Friday that he recently discovered an ailment that required surgery. After his New Orleans show on Sept. 7, he sought tests at a hospital and canceled a Houston show the following night. In a note on X, he did not elaborate on his condition.

    “My path to recovery is something I need to confront seriously,” Glover wrote.

    “The New World Tour” is Childish Gambino’s first tour since 2019. The run began on Aug. 11 in Oklahoma City and was to hit many major North American cities before moving to Europe, the U.K., New Zealand and Australia into early 2025.

    The cancellation affects over 30 scheduled dates in North America, the U.K. and Europe. Tickets, he said, will be refunded.

    “I want nothing more than to bring this show to the fans and perform,” Glover wrote. “Until then, thanks for love, privacy, and support.”

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