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Tag: rsv

  • Hospitalizations on the rise in New York City as new COVID strains spread rapidly

    Hospitalizations on the rise in New York City as new COVID strains spread rapidly

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    Hospitalizations are rising again in New York City with the spread of new COVID-19 subvariants that are better at evading immunity. Cases of flu and respiratory syncytial virus, or RSV, are also increasing.

    State data show about 1,100 patients hospitalized with COVID as of Oct. 24, up from 750 in mid-September, as the New York Times reported. Case numbers have held steady, although with many people testing at home where data are not being collected, those numbers are not reliable.

    Data from the Centers for Disease Control and Prevention show that the omicron sublineages named BQ.1 and BQ.1.1 accounted for 42.5% of all cases in the New York region in the week through Oct. 29, up from 37% the previous week.

    That was more than the BA.5 omicron subvariant, which accounted for 35.7% of new cases in the New York region in the latest week. The two sublineages were not even registering as recently as three weeks ago, demonstrating just how fast they are spreading.

    Experts are also concerned about a nationwide surge in RSV, which can cause breathing difficulties in small children and older adults and for which there is currently no vaccine.

    There was good news from Pfizer Inc., however, which said Tuesday that data from a late-stage trial of an RSV vaccine had proved effective in preventing severe illness in children up to 6 months old.

    The Phase 3 trial found that the vaccine, given to pregnant mothers, achieved vaccine efficacy of 81.8% in infants from birth through the first 90 days of life. The trial found efficacy of 69.4% through the first 6 months of life.

    Pfizer
    PFE,
    +3.14%

    said it expects to make its first U.S. regulatory application for the vaccine by the end of 2022 and to follow on with other regulatory bodies. It will also submit the results of the trial for peer review in a scientific journal.

    The daily U.S. average for new COVID cases stood at 37,665 on Monday, according to a New York Times tracker, which was flat as compared with two weeks ago. The daily average for hospitalizations was up 2% to 27,184, while the daily average for deaths was down 3% to 348. 

    Coronavirus Update: MarketWatch’s daily roundup has been curating and reporting all the latest developments every weekday since the coronavirus pandemic began

    Other COVID-19 news you should know about:

    • Apple 
    AAPL,
    -1.75%

    supplier Foxconn
    2317,

    said Tuesday it has quadrupled bonuses for workers at its Zhengzhou plant in central China as it seeks to quell discontent over COVID restrictions and retain staff at the giant iPhone manufacturing site, Reuters reported. Daily bonuses for employees, who are part of a Foxconn unit responsible for making electronics including smartphones, have been raised to 400 yuan ($55) a day for November from 100 yuan, according to the official WeChat account of Foxconn’s Zhengzhou plant. The move comes after workers fled the site over the weekend to avoid COVID curbs after complaining about their treatment and provisions via social media.

    Workers at the world’s biggest assembly site for Apple’s iPhones walked out as Foxconn has struggled to contain a COVID-19 outbreak. The chaos highlights the tension between Beijing’s rigid pandemic controls and the urge to keep production on track. Photo: Hangpai Xinyang/Associated Press

    • The Wall Street Journal reported Tuesday that Hong Kong stocks appeared to be rallying after an anonymous post on Chinese social media suggested that the government may intend to soften pandemic-related restrictions beginning in March. Other outlets also reported on the rumor. American depositary receipts for Chinese companies surged on the news.

    See: Alibaba and Nio among Chinese stocks surging as hopes build about potential reopening

    • Pfizer’s COVID antiviral Paxlovid brought in $7.5 billion in sales in the third quarter of the year, compared with a FactSet consensus of $7.6 billion. The drug company also reiterated guidance for Paxlovid revenues in 2022, saying it still expects $22 billion in sales for the year. The FactSet consensus is $22.5 billion. Pfizer raised its full-year revenue guidance for the company’s Comirnaty COVID vaccine by $2 billion to $34 billion. The guidance includes doses expected to be delivered in fiscal 2022, primarily under contracts signed as of mid-October.

    • AstraZeneca PLC’s
    AZN,
    +1.77%

    AZN,
    +0.90%

    COVID vaccine Vaxzevria has been granted full marketing authorization in the European Union, Dow Jones Newswires reported. The Anglo-Swedish pharmaceutical giant said Vaxzevria has been shown to be effective against all forms of the virus. Vaxzevria was originally granted conditional marketing authorization due to the urgency of the COVID-19 pandemic, it said.

    Here’s what the numbers say:

    The global tally of confirmed cases of COVID-19 topped 630.6 million on Monday, while the death toll rose above 6.59 million, according to data aggregated by Johns Hopkins University.

    The U.S. leads the world with 97.5 million cases and 1,070,429 fatalities.

    The Centers for Disease Control and Prevention’s tracker shows that 226.9 million people living in the U.S., equal to 68.4% of the total population, are fully vaccinated, meaning they have had their primary shots.

    So far, just 22.8 million Americans have had the updated COVID booster that targets the original virus and the omicron variants, equal to 7.3% of the overall population.

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  • The Worst Pediatric-Care Crisis in Decades

    The Worst Pediatric-Care Crisis in Decades

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    At the height of the coronavirus pandemic, as lines of ambulances roared down the streets and freezer vans packed into parking lots, the pediatric emergency department at Our Lady of the Lake Children’s Hospital, in Baton Rouge, Louisiana, was quiet.

    It was an eerie juxtaposition, says Chris Woodward, a pediatric-emergency-medicine specialist at the hospital, given what was happening just a few doors down. While adult emergency departments were being inundated, his team was so low on work that he worried positions might be cut. A small proportion of kids were getting very sick with COVID-19—some still are—but most weren’t. And due to school closures and scrupulous hygiene, they weren’t really catching other infections—flu, RSV, and the like—that might have sent them to the hospital in pre-pandemic years. Woodward and his colleagues couldn’t help but wonder if the brunt of the crisis had skipped them by. “It was, like, the least patients I saw in my career,” he told me.

    That is no longer the case.

    Across the country, children have for weeks been slammed with a massive, early wave of viral infections—driven largely by RSV, but also flu, rhinovirus, enterovirus, and SARS-CoV-2. Many emergency departments and intensive-care units are now at or past capacity, and resorting to extreme measures. At Johns Hopkins Children’s Center, in Maryland, staff has pitched a tent outside the emergency department to accommodate overflow; Connecticut Children’s Hospital mulled calling in the National Guard. It’s already the largest surge of infectious illnesses that some pediatricians have seen in their decades-long careers, and many worry that the worst is yet to come. “It is a crisis,” Sapna Kudchadkar, a pediatric-intensive-care specialist and anesthesiologist at Johns Hopkins, told me. “It’s bananas; it’s been full to the gills since September,” says Melissa J. Sacco, a pediatric-intensive-care specialist at UVA Health. “Every night I turn away a patient, or tell the emergency department they have to have a PICU-level kid there for the foreseeable future.”

    I asked Chris Carroll, a pediatric-intensive-care specialist at Connecticut Children’s, how bad things were on a scale of 1 to 10. “Can I use a Spinal Tap reference?” he asked me back. “This is our 2020. This is as bad as it gets.”

    The autumn crush, experts told me, is fueled by dual factors: the disappearance of COVID mitigations and low population immunity. For much of the pandemic, some combination of masking, distancing, remote learning, and other tactics tamped down on the transmission of nearly all the respiratory viruses that normally come knocking during the colder months. This fall, though, as kids have flocked back into day cares and classrooms with almost no precautions in place, those microbes have made a catastrophic comeback. Rhinovirus and enterovirus were two of the first to overrun hospitals late this summer; now they’re being joined by RSV, all while SARS-CoV-2 remains in play. Also on the horizon is flu, which has begun to pick up in the South and the mid-Atlantic, triggering school closures or switches to remote learning. During the summer of 2021, when Delta swept across the nation, “we thought that was busy,” Woodward said. “We were wrong.”

    Children, on the whole, are more susceptible to these microbes than they have been in years. Infants already have a rough time with viruses like RSV: The virus infiltrates the airways, causing them to swell and flood with mucus that their tiny lungs may struggle to expel. “It’s almost like breathing through a straw,” says Marietta Vazquez, a pediatric-infectious-disease specialist at Yale. The more narrow and clogged the tubes get, “the less room you have to move air in and out.” Immunity accumulated from prior exposures can blunt that severity. But with the pandemic’s great viral vanishing, kids missed out on early encounters that would have trained up their bodies’ defensive cavalry. Hospitals are now caring for their usual RSV cohort—infants—as well as toddlers, many of whom are sicker than expected. Infections that might, in other years, have produced a trifling cold are progressing to pneumonia severe enough to require respiratory support. “The kids are just not handling it well,” says Stacy Williams, a PICU nurse at UVA Health.

    Coinfections, too, have always posed a threat—but they’ve grown more common with SARS-CoV-2 in the mix. “There’s just one more virus they’re susceptible to,” Vazquez told me. Each additional bug can burden a child “with a bigger hill to climb, in terms of recovery,” says Shelby Lighton, a nurse at UVA Health. Some patients are leaving the hospital healthy, only to come right back. There are kids who “have had four respiratory viral illnesses since the start of September,” Woodward told me.

    Pediatric care capacity in many parts of the country actually shrank after COVID hit, Sallie Permar, a pediatrician at NewYork-Presbyterian and Weill Cornell Medicine, whose hospital was among those that cut beds from its PICU, told me. A mass exodus of health-care workers—nurses in particular—has also left the system ill-equipped to meet the fresh wave of demand. At UVA Health, the pediatric ICU is operating with maybe two-thirds of the core staff it needs, Williams said. Many hospitals have been trying to call in reinforcements from inside and outside their institutions. But “you can’t just train a bunch of people quickly to take care of a two-month-old,” Kudchadkar said. To make do, some hospitals are doubling up patients in rooms; others have diverted parts of other care units to pediatrics, or are sending specialists across buildings to stabilize children who can’t get a bed in the ICU. In Baton Rouge, Woodward is regularly visiting the patients who have just been admitted to the hospital and are still being held in the emergency department, trying to figure out who’s healthy enough to go home so more space can be cleared. His emergency department used to take in, on average, about 130 patients a day; lately, that number has been closer to 250. “They can’t stay,” he told me. “We need this room for somebody else.”

    Experts are also grappling with how to strike the right balance between raising awareness among caregivers and managing fears that may morph into overconcern. On the one hand, with all the talk of SARS-CoV-2 being “mild” in kids, some parents might ignore the signs of RSV, which can initially resemble those of COVID, then get much more serious, says Ashley Joffrion, a respiratory therapist at Baton Rouge General Medical Center. On the other hand, if families swamp already overstretched hospitals with illnesses that are truly mild enough to resolve at home, the system could fracture even further. “We definitely don’t want parents bringing kids in for every cold,” Williams told me. The key signs of severe respiratory sickness in children include wheezing, grunting, rapid or labored breaths, trouble drinking or swallowing, and bluing of the lips or fingernails. When in doubt, experts told me, parents should call their pediatrician for an assist.

    With winter still ahead, the situation could take an even darker turn, especially as flu rates climb, and new SARS-CoV-2 subvariants loom. In most years, the chilly viral churn doesn’t abate until late winter, which means hospitals may be only at the start of a grueling few months. And still-spotty uptake of COVID vaccines among little kids, coupled with a recent dip in flu-shot uptake and the widespread abandonment of infection-prevention measures, could make things even worse, says Abdallah Dalabih, a pediatric-intensive-care specialist at Arkansas Children’s.

    The spike in respiratory illness marks a jarring departure from a comforting narrative that’s dominated the intersection of infectious disease and little children’s health for nearly three years. When it comes to respiratory viruses, little children have always been a vulnerable group. This fall may force Americans to reset their expectations around young people’s resilience and recall, Lighton told me, “just how bad a ‘common cold’ can get.”

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    Katherine J. Wu

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  • New omicron subvariants accounted for more cases in New York region in latest week than BA.5, CDC data shows

    New omicron subvariants accounted for more cases in New York region in latest week than BA.5, CDC data shows

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    The omicron sublineages named BQ.1 and BQ.1.1 continued to spread in the U.S. in the week through Oct. 29, accounting for 27.1% of new cases nationwide, according to Centers for Disease Control and Prevention data.

    The two accounted for 42.5% of all cases in the New York region, which includes New Jersey, Puerto Rico and the Virgin Islands, up from 37% the previous week. That was more than the BA.5 omicron subvariant, which accounted for 35.7% of new cases in the New York area in the latest week.

    The BA.5 omicron subvariant accounted for 49.6% of all U.S. cases, the data show.

    BQ.1 and BQ.1.1 were included in BA.5 variant data as recently as three weeks ago, because their numbers were too small to break out. BQ.1 was first identified by researchers in early September and has been found in the U.K. and Germany, among other places.

    Last week, the World Health Organization said that BQ.1 and another sublineage dubbed XBB do not appear to have immune-escape mutations that warrant being designated as variants of concern. However, BA.5 is still a variant of concern that is being closely monitored, said a statement from the WHO’s Technical Advisory Group on SARS-CoV-2 Virus Evolution.

    Workers in a manufacturing facility that assemble Apple Inc.’s
    AAPL,
    -1.66%

    iPhone in the Chinese city of Zhengzhou appear to have left to avoid COVID-19 curbs, with many traveling on foot for days after an unknown number of employees were quarantined in the facility after a virus outbreak, the Associated Press reported. 

    Videos circulating on Chinese social media platforms showed people who are allegedly Foxconn workers climbing over fences and carrying their belongings down a road.

    Separately, visitors to Shanghai Disneyland were left stranded at the park on Monday after the resort halted operations to comply with COVID-19 restrictions amid a new outbreak of the virus.

    In the U.S., known cases of COVID are continuing to ease and now stand at their lowest level since mid-April, although the true tally is likely higher given how many people overall are testing at home, where data are not being collected.

    The daily average for new cases stood at 36,869 on Sunday, according to a New York Times tracker, down 2% from two weeks ago. The daily average for hospitalizations was up 3% to 27,415, while the daily average for deaths was down 6% to 352. 

    Coronavirus Update: MarketWatch’s daily roundup has been curating and reporting all the latest developments every weekday since the coronavirus pandemic began

    Other COVID-19 news you should know about:

    • With a downcast earnings season passing the halfway mark, results from financial-technology companies and vaccine makers will arrive this week amid questions about consumer spending as well as demand for COVID drugs, MarketWatch’s Bill Peters reported. Pfizer Inc.
    PFE,
    -1.82%

    will report earnings on Tuesday, followed by Moderna Inc.
    MRNA,
    -0.47%

    on Thursday. Analysts will have their eye on the state of COVID-19 vaccine and treatment sales and on what executives are anticipating for the full year, as they prepare for a private market for COVID medications and as more people shrug off the pandemic. Pfizer executives, during a call last week, said they intended to charge between $110 and $130 for a single-dose vial of the vaccine for U.S. adults when government purchases end. But they said they believe anyone who has health insurance shouldn’t have to pay anything out of pocket.

    The FDA authorized newly modified COVID-19 boosters to target the latest versions of the omicron variant. But as WSJ’s Daniela Hernandez explains, a key part of the decision-making process was changed with these new shots. Photo: Laura Kammermann

    • A number of young children are being hospitalized because of respiratory syncytial virus, or RSV, and it’s happening at an unusual time of year and among older children than in years past, MarketWatch’s Jaimy Lee reported. COVID may be a contributing factor, in part because many children were not exposed to RSV last season and also because a prior COVID infection or exposure may change the way a baby’s immune system responds to RSV and may lead to more severe illness from an RSV infection, according to Asuncion Mejias, a principal investigator with the Center for Vaccines and Immunity at the Research Institute at Nationwide Children’s Hospital in Columbus, Ohio.

    • On Saturday, more than 3,000 people took part in the first Pride march in South Africa since the COVID pandemic , celebrating the LGBT community and defying a U.S. warning of a possible terror attack in the area, the AP reported. The U.S. government this week warned of a possible attack in the Sandton part of Johannesburg, where the march took place. The South African government expressed concern that the U.S. had not shared enough information to give credibility to the alleged threat. Police said all measures had been taken to ensure safety in the area.

    Here’s what the numbers say:

    The global tally of confirmed cases of COVID-19 topped 630.2 million on Monday, while the death toll rose above 6.58 million, according to data aggregated by Johns Hopkins University.

    The U.S. leads the world with 97.5 million cases and 1,070,266 fatalities.

    The Centers for Disease Control and Prevention’s tracker shows that 226.9 million people living in the U.S., equal to 68.4% of the total population, are fully vaccinated, meaning they have had their primary shots.

    So far, just 22.8 million Americans have had the updated COVID booster that targets the original virus and the omicron variants, equal to 7.3% of the overall population.

     

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  • COVID-19 may be to blame for the surge in RSV illness among children. Here’s why.

    COVID-19 may be to blame for the surge in RSV illness among children. Here’s why.

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    A number of young children are being hospitalized because of respiratory syncytial virus, or RSV, and it’s happening at an unusual time of year and among older children than in years past.

    RSV infections and related emergency-room visits and hospitalizations are nearing seasonal peaks in some U.S. regions, according to the Centers for Disease Control and Prevention.

    But the current RSV outbreak is different from previous outbreaks in several ways: It’s happening in the fall rather than the winter (RSV commonly peaks after the holidays, starting in late December); older children and not just infants are being hospitalized; and cases are occurring that are more severe than in previous years. And this year, RSV is circulating at the same time as COVID, influenza, and other viruses like the biennial enterovirus, which was behind a rise in pediatric hospitalizations earlier this fall. 

    “The theory is that everyone’s now back together, and this is a rebound phenomenon,” said Jeffrey Kline, a physician and associate chair of research for emergency medicine at Wayne State University School of Medicine in Detroit.

    Kline runs a national surveillance network that gathers data about viral infections from about 70 hospitals, including four pediatric hospitals. He says those data show that 318 children were hospitalized with acute respiratory illness brought on by RSV in the week starting Oct. 9, compared with 45 hospitalizations in the week starting July 25.  

    “If we think about the relative increase — ninefold increase — that’s not nothing, especially in the pediatric [emergency departments],” Kline said. “Holy mackerel.”


    Source: CDC

    The U.S. saw a massive spike in RSV cases in the summer of 2021, after masking and social distancing resulted in a lull in infections the previous year. Even with that spike, fewer young children — 2-, 3-, and 4-year-olds — have been exposed to RSV than in a normal year. Most children have usually had at least one RSV infection by the time they are 2 years old, and as children get older, RSV becomes less worrisome, according to the CDC. Infants are at higher risk for severe disease brought on by RSV because babies have more immature immune responses than older children and because infants younger than 6 months of age breathe exclusively through their noses and cannot breathe through their mouths if they are congested.

    “Age by itself is a risk factor for more severe disease, meaning that the younger babies are usually the ones that are sick-sick,” said Asuncion Mejias, a principal investigator with the Center for Vaccines and Immunity at the Research Institute at Nationwide Children’s Hospital in Columbus, Ohio. Now, she added, “we are seeing also older kids, probably because they were not exposed to RSV the previous season.”

    But there’s another reason that COVID may be worsening some RSV infections in the youngest children. Mejias is studying whether a prior COVID infection or exposure somehow changes the way a baby’s immune system responds to RSV and whether it may lead to more severe illness from an RSV infection. 

    “That is something to work on and understand,” she said. 

    For now, however, worries are tied to the possibility of a “tripledemic” of COVID, influenza, and RSV as the U.S. heads into what is expected to be a complicated season for respiratory infections. Stat News reported in mid-October that flu season is already underway, and the CDC said this week that this year’s flu activity may have “atypical timing and intensity.” 

    COVID itself remains a threat, as well. There are still more children being hospitalized with COVID than with RSV, Kline said, and some kids are getting sick from both viruses at the same time. About 5% of children are thought to test positive for both RSV and COVID, and 60% of the children in that group were hospitalized, according to Kline’s surveillance network. 

    “All these things are going on all at once right now,” said Alex Frost, managing director for StudyMaker, which is providing software infrastructure to the network. “But the shape of pediatric cases that are showing up in the emergency room is different than it used to be.”

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  • Is It Flu, RSV or COVID? Experts Fear the ‘Tripledemic’

    Is It Flu, RSV or COVID? Experts Fear the ‘Tripledemic’

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    Oct. 25, 2022 – Just when we thought this holiday season, finally, would be the back-to-normal one, some infectious disease experts are warning that a so-called tripledemic – influenza, COVID-19, and RSV – may be in the forecast.

    The warning isn’t without basis. 

    • The flu season has gotten an early start. As of Oct. 21, early increases in seasonal flu activity have been reported in most of the country, the CDC says, with the southeast and south-central areas having the highest activity levels. 
    • Children’s hospitals and emergency departments are seeing a surge in children with RSV.
    • COVID-19 cases are trending down, according to the CDC, but epidemiologists – scientists who study disease outbreaks – always have their eyes on emerging variants. 

    Predicting exactly when cases will peak is difficult, says Justin Lessler, PhD, a professor of epidemiology at the University of North Carolina at Chapel Hill. Lessler is on the coordinating team for the COVID-19 Scenario Modeling Hub, which aims to predict the course COVID-19, and the Flu Scenario Modeling Hub, which does the same for influenza.

    For COVID-19, some models are predicting some spikes before Christmas, he says, and others see a new wave in 2023. For the flu, the model is predicting an earlier-than-usual start, as the CDC has reported.  

    While flu activity is relatively low, the CDC says, the season is off to an early start. For the week ending Oct. 21, 1,674 patients were hospitalized for flu, higher than in the summer months but fewer than the 2,675 hospitalizations for the week of May 15, 2022. 

    As of Oct. 20, COVID-19 cases have declined 12% over the last 2 weeks, nationwide. But hospitalizations are up 10% in much of the Northeast, The New York Times reports, and the improvement in cases and deaths has been slowing down. 

    As of Oct. 15, 15% of RSV tests reported nationwide were positive, compared with about 11% at that time in 2021, the CDC says. The surveillance collects information from 75 counties in 12 states. 

    Experts point out that the viruses — all three are respiratory viruses —  are simply playing catchup. 

    “They spread the same way and along with lots of other viruses, and you tend to see an increase in them during the cold months,” says Timothy Brewer, MD, professor of medicine and epidemiology at UCLA.

    The increase in all three viruses “is almost predictable at this point in the pandemic,” says Dean Blumberg, MD, a professor and chief of pediatric infectious diseases at the University of California Davis Health. “All the respiratory viruses are out of whack.” 

    Last year, RSV cases were up, too, and began to appear very early, he says, in the summer instead of in the cooler months. Flu also appeared early in 2021, as it has this year. 

    That contrasts with the flu season of 2020-2021, when COVID precautions were nearly universal, and cases were down. At UC Davis, “we didn’t have one pediatric admission due to influenza in the 2020-2021 [flu] season,” Blumberg says. 

    The number of pediatric flu deaths usually range from 37 to 199 per year, according to CDC records. But in the 2020-2021 season, the CDC recorded one pediatric flu death in the U.S.

    Both children and adults have had less contact with others the past 2 seasons, Blumberg says, “and they don’t get the immunity they got with those infections [previously]. That’s why we are seeing out-of-season, early season [viruses].” 

    Eventually, he says, the cases of flu and RSV will return to previous levels. “It could be as soon as next year,” Blumberg says. And COVID-19, hopefully, will become like influenza, he says.

    “RSV has always come around in the fall and winter,” says Elizabeth Murray, DO, a pediatric emergency medicine doctor at the University of Rochester Medical Center and a spokesperson for the American Academy of Pediatrics. This year, children are back in school and for the most part not masking, she says. “It’s a perfect storm for all the germs to spread now. They’ve just been waiting for their opportunity to come back.” 

    Self-Care vs. Not

    RSV can pose a risk for anyone, but most at risk are children under age 5, especially infants under age 1, and adults over age 65.  There is no vaccine for it. Symptoms include a runny nose, decreased appetite, coughing, sneezing, fever, and wheezing. But in young infants, there may only be decreased activity, crankiness, and breathing issues, the CDC says.

    Keep an eye on the breathing if RSV is suspected, Murray tells parents. If your child can’t breathe easily, is unable to lie down comfortably, can’t speak clearly, or is sucking in the chest muscles to breathe, get medical help. Most kids with RSV can stay home and recover, she says, but often will need to be checked by a medical professional.

    She advises against getting an oximeter to measure oxygen levels for home use. “They are often not accurate,” she says. If in doubt about how serious your child’s symptoms are, “don’t wait it out,” she says, and don’t hesitate to call 911.

    Symptoms of flu, COVID, and RSV can overlap.  But each can involve breathing problems, which can be an emergency. 

    “It’s important to seek medical attention for any concerning symptoms, but especially severe shortness of breath or difficulty breathing, as these could signal the need for supplemental oxygen or other emergency interventions,” says Mandy De Vries, a respiratory therapist and director of education at the American Association for Respiratory Care. Inhalation treatment or mechanical ventilation may be needed for severe respiratory issues.

    Precautions

    To avoid the tripledemic – or any single infection – Timothy Brewer, MD, a professor of medicine and epidemiology at UCLA, suggests some familiar measures: “Stay home if you’re feeling sick. Make sure you are up to date on your vaccinations. Wear a mask indoors.”

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  • What the RSV Surge Means for Doctors and Patients

    What the RSV Surge Means for Doctors and Patients

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    Oct. 25, 2022 — In early October, respiratory syncytial virus, or RSV, tore through Victoria Thiele’s Indiana home. Her three older children had manageable symptoms. But her 8-week-old newborn ended up developing a severe case.

    Thiele, whose family lives in Fort Wayne, said the baby experienced chest retractions while breathing and was taken to the emergency room at a local hospital, where she was diagnosed with RSV and bacterial pneumonia.

    An Unprecedented Surge in RSV 

    Thiel’s experience mirrors what’s happening across the country. On Oct. 21,  the CDC director tweeted that respiratory viruses, including the flu and RSV, are surging. Data from the CDC shows the percentage of those testing positive for RSV has more than doubled over the past month – straining the capacity of children’s’ hospitals as they try to care for the sickest patients. 

    “Nobody has enough beds,”  says Renee Higgerson, MD, pediatric intensivist and medical director at Pediatrix Critical Care of Texas and St. David’s Children’s Hospital. “We’re taking care of patients in every possible location we can in the hospital.”

    Yvonne Giunta, MD, director of pediatric emergency medicine at Staten Island University Hospital, part of Northwell Health in New York, said the pediatric emergency department at her facility is seeing a high volume of RSV cases, along with other respiratory infections. 

    “It’s not uncommon for a surge in pediatric volume in the late fall and early winter,” Giunta says. “But this surge seems to have started earlier than in previous years.”

    What’s Behind the Surge? 

    RSV usually has a predictable seasonal pattern, peaking in late December to mid February, according to the CDC. The virus hits young children hardest, causing about 58,000 hospitalizations of kids under the age of 5, and 100 to 300 deaths per year in that age group. But as the CDC noted, RSV was almost nonexistent in 2020, when pandemic prevention methods nearly knocked the virus out of circulation.

    Christopher J. Harrison MD, professor of pediatrics at the University of Missouri-Kansas City, said children get RSV by the time they are 2, and these first exposures make children less susceptible to the virus. 

    But the COVID pandemic means that some children born over the past couple of years were never exposed to RSV. 

    “Since the hiatus where we lost regular viruses, we ended up really shaking up the whole epidemiology thing,” Harrison says. 

    The loosening of pandemic control measures coupled with a much more susceptible younger population is a “perfect storm” for this outbreak, he notes. 

    Hospitals Pitching In 

    Higgerson says she has been heartened by how hospitals in her area have come together, inviting patients to take free hospital beds on the rare occasions they become available. 

    “Everybody is working cooperatively,” she says. 

    But the biggest hurdles are nursing and staffing shortages

    “We’re opening some sections of the adult hospital, creating pediatric beds,” she says. “But what’s limiting us is the availability of nurses. We just need more nurses.”

    Giunta says she is already strategizing ways to accommodate staffing needs. 

    “We are encouraging the swing shift, which typically would cover mainly the adult emergency department, to cross-cover the pediatric area in the later afternoon and evening hours,” she says. 

    Educating Parents 

    Michael Chang, MD, a pediatric infectious disease specialist at UT Health Houston and Children’s Memorial Hermann Hospital, whose facility is also operating at or near capacity due to a high volume of RSV, stresses the importance of parent education when it comes to managing this outbreak.

    Many parents have resumed normal pre-pandemic activities and are burned out by pandemic protocols, Chang says.

    “People are so tired of thinking about the pandemic that we have really returned to our prior behavior of shrugging off mild illnesses, runny noses, etc.,” he says. 

    Hospitals and pediatric offices should emphasize the ABCs of disease prevention when it comes to RSV, such as avoiding crowds, staying home when sick, and hand washing, Chang says. Teaching parents to recognize when symptoms can be managed at home, and when to take a child to the ER, could also help decrease the number of patients overwhelming emergency rooms. 

    What Parents Need to Know 

    In most children, RSV causes mild cold symptoms like sore throat, congestion, and coughing. But for children under the age of 2, children with weak immune systems, or those with asthma, RSV can be more serious.

    In vulnerable children, RSV can cause bronchiolitis, an inflammation of the small airways, making it difficult to breathe. It can also cause pneumonia.

    Most cases of RSV can be treated at home with extra fluids, cool-mist humidifiers, and nasal suctioning. But some children may need emergency medical care.

    Theile’s baby was put on high-flow oxygen, but her oxygen levels remained below normal. 

    “At that point, they told me she would need to be put on a ventilator,” Theile says. 

    After 4 days of ventilation, antibiotics, and treatment with steroids, the infant was able to breathe on her own. Thiele says she’s grateful for the compassionate care her daughter received, but that the atmosphere at the hospital was chaotic and frightening.

    “When we went into the ER, they had to take her stats in a hallway because all rooms were full of children with RSV,” Thiele says. “The PICU was filled with the sounds of children coughing and monitors going off due to their stats going down. It was truly heartbreaking.”

    According to the Academy of American Pediatrics, signs your child may need immediate medical attention include:

    • Labored breathing
    • Flared nostrils while breathing
    • Retractions at the belly or ribs
    • Sucking in at the collarbone while breathing
    • Wheezing
    • Gray or blue skin or lips
    • Extreme lethargy
    • Dehydration symptoms, such as decreased wet diapers

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