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  • How Lindsey Vonn can compete with a ruptured ACL

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    Lindsey Vonn wiped out in a downhill race on Jan. 30. She got up limping, then was airlifted from the course. The diagnosis: a ruptured ACL — a season-ending injury for most.But the three-time Olympic medalist announced on Tuesday she would go on to compete in her fifth Games.On Friday, she completed her downhill training run without issue at the Tofane Alpine Skiing Centre ahead of Sunday’s medal event in Cortina d’Ampezzo.Video above: U.S. Skiers talk about Lindsey Vonn competing in Italy Olympics despite torn ACLFor anyone who’s hobbled off the field, it’s hard not to ask: How?“It is a big deal to tear your ACL,” said Lindsey Lepley, an associate professor of athletic training at the University of Michigan. “And doing anything while being ACL-deficient is a big deal.”Vonn, 41, who is set to be the oldest Alpine skier to race at a Winter Olympics, has an extensive history of knee injuries and surgeries, including two prior ACL injuries. Dr. Martin Roche, a surgeon at the Hospital for Special Surgery, says Vonn’s first injuries date back to the beginning of her professional career in the 2000s.She’s had problems with both knees, but her left was the “stronger” one, according to Roche, who performed a partial knee replacement on the Olympian’s right knee in 2024. After Friday’s crash, her left knee is now injured — a new turn in Vonn’s long injury saga.What is the ACL and why is it important?The ACL — also known as the anterior cruciate ligament — is a ligament that connects the bones of the knee, stabilizing the joint and preventing one bone from sliding in front of the other.“The knee is not a joint that is completely stable,” Dr. Anthony Petrosini, an orthopedic surgeon at Hackensack Meridian Health, said. “The ligaments play a great role in keeping the knee in position.”Petrosini, who has torn his own ACL, says the structure is easily injured because it has a hefty responsibility in controlling the knee’s rotational stability. It’s the most common knee injury, affecting more than 200,000 people per year in the United States.Weight-bearing and high-speed activities, particularly those involving sudden twists and stops, place the greatest burden on the ACL.And skiing fits that bill. It’s among the highest-risk sports for ACL injuries. Vonn’s sex and prior injuries further increase that risk.When injured, the ACL can be partially torn, also known as a tear, or fully separated, referred to as a rupture. The terms are frequently used interchangeably, as Vonn did on Tuesday.What happens when the ACL is injured?A jolt of pain is felt when the ACL is first injured. Some people also feel a pop or instability in the knee. Fluid then accumulates in the joint, causing swelling and stiffness. The inflammatory response can also cause a locking sensation and reduced range of motion.For many, that means trouble standing on the injured knee and continued pain.The structures above the knee also feel the pain. Lepley studies how muscles of the upper leg shut down after a knee injury — a process called muscle inhibition.“It’s sort of this unique forgetfulness that happens between the brain and the muscle,” Lepley said.The injury also travels up to the brain, triggering a fear response. “People are going to have fear of re‑injury,” Lepley explained, noting the psychological component can cause someone to change movement patterns.That’s why, Lepley says, Vonn was likely performing box jumps after the injury. “They’re sort of testing that fear,” Lepley said, noting the exercises can also help fight off muscle inhibition. “If you can’t jump and stabilize yourself on solid ground, that’s a good indication that somebody has too much hesitation.”In a video posted on Instagram on Thursday, a day before her completed training run, Vonn squats with weights, lunges from side to side and does fast kicks against a ball.How to treat an injured ACLOnce the ACL is torn, it doesn’t regenerate in the same way that bone does. “Unfortunately, we’re not like lizards,” Lepley said.Most people undergo surgery to reconstruct the ligament, and nearly all athletes get the procedure after the injury, according to Roche.While a surgical approach doesn’t speed up recovery time, it can stabilize the knee, reduce the risk of further injury and allow for return to high-demanding activities like skiing. Some data suggests surgery can also reduce the risk of osteoarthritis — a common long-term concern after ACL injury — though the evidence is conflicting.Regardless of whether someone has surgery, months of rehab are standard. Those who don’t opt for surgery stick to pain control and rehab, learning to live without a functioning ACL.Vonn said on Tuesday that surgery “hasn’t been discussed.”“It’s not really on my radar screen right now. The Olympics are the only thing that I’m thinking about,” she said. “We’re doing everything to make sure I am making smart and safe decisions.”Has anyone ever skied on an injured ACL?Yes, some of Vonn’s teammates said they’ve done it. Other skiers, like Slovakian Veronika Velez-Zuzulová have done it, too. And Vonn says she’s done it before.“It’s possible,” Roche said. But other parts of the leg need to compensate.“When that ligament is gone, your muscles have to step up to help stabilize the joint,” Lepley said.All the experts CNN spoke with emphasized that an immediate return to competition is far from the norm — and not recommended. Far more often, athletes do the opposite. Hitting the slopes would expose Vonn to substantial risk of further injury.Plus, there was more to her injury. She also reported bone bruising and meniscal damage, both common companions to ACL injuries. These additional injuries raise the risk further, making her return to racing even more dangerous. The good news, though, is that Vonn didn’t report any significant bone fractures, Roche said.Roche, who knows Vonn’s medical history well, says it comes down to the athlete.“She knows her body better than anyone,” Roche said. “She’ll be able to determine if she can overcome any injury to her knee quickly or if it’s going to set her back.”What to watch for when Vonn returns for fresh powderVonn is set to begin racing on Sunday.“I don’t think she’s going to be able to perform at 100%,” Lepley said. “But I think she’s going to be able to make the best of a bad situation.”Parts of the course that put more stress on one knee could be especially risky. Lepley says the Olympian might lack symmetry as she compensates.The biggest concern is Vonn’s meniscus, which acts as a shock absorber and helps the knee move smoothly. Without a functioning ACL, the structure is more vulnerable and, if injured, it’s notoriously difficult to heal.At the finish line, three things will matter most, Lepley says: a medical exam to check for any additional damage, close monitoring of pain and swelling and a renewed focus on restoring normal motion and walking. And if her knees are on her side, a medal.“She’s in good hands,” Petrosini said. “To be able to pull off what she’s attempting is really remarkable.”

    Lindsey Vonn wiped out in a downhill race on Jan. 30. She got up limping, then was airlifted from the course. The diagnosis: a ruptured ACL — a season-ending injury for most.

    But the three-time Olympic medalist announced on Tuesday she would go on to compete in her fifth Games.

    On Friday, she completed her downhill training run without issue at the Tofane Alpine Skiing Centre ahead of Sunday’s medal event in Cortina d’Ampezzo.

    Video above: U.S. Skiers talk about Lindsey Vonn competing in Italy Olympics despite torn ACL

    For anyone who’s hobbled off the field, it’s hard not to ask: How?

    “It is a big deal to tear your ACL,” said Lindsey Lepley, an associate professor of athletic training at the University of Michigan. “And doing anything while being ACL-deficient is a big deal.”

    Vonn, 41, who is set to be the oldest Alpine skier to race at a Winter Olympics, has an extensive history of knee injuries and surgeries, including two prior ACL injuries. Dr. Martin Roche, a surgeon at the Hospital for Special Surgery, says Vonn’s first injuries date back to the beginning of her professional career in the 2000s.

    She’s had problems with both knees, but her left was the “stronger” one, according to Roche, who performed a partial knee replacement on the Olympian’s right knee in 2024. After Friday’s crash, her left knee is now injured — a new turn in Vonn’s long injury saga.

    What is the ACL and why is it important?

    The ACL — also known as the anterior cruciate ligament — is a ligament that connects the bones of the knee, stabilizing the joint and preventing one bone from sliding in front of the other.

    “The knee is not a joint that is completely stable,” Dr. Anthony Petrosini, an orthopedic surgeon at Hackensack Meridian Health, said. “The ligaments play a great role in keeping the knee in position.”

    Petrosini, who has torn his own ACL, says the structure is easily injured because it has a hefty responsibility in controlling the knee’s rotational stability. It’s the most common knee injury, affecting more than 200,000 people per year in the United States.

    Weight-bearing and high-speed activities, particularly those involving sudden twists and stops, place the greatest burden on the ACL.

    And skiing fits that bill. It’s among the highest-risk sports for ACL injuries. Vonn’s sex and prior injuries further increase that risk.

    When injured, the ACL can be partially torn, also known as a tear, or fully separated, referred to as a rupture. The terms are frequently used interchangeably, as Vonn did on Tuesday.

    What happens when the ACL is injured?

    A jolt of pain is felt when the ACL is first injured. Some people also feel a pop or instability in the knee. Fluid then accumulates in the joint, causing swelling and stiffness. The inflammatory response can also cause a locking sensation and reduced range of motion.

    For many, that means trouble standing on the injured knee and continued pain.

    The structures above the knee also feel the pain. Lepley studies how muscles of the upper leg shut down after a knee injury — a process called muscle inhibition.

    “It’s sort of this unique forgetfulness that happens between the brain and the muscle,” Lepley said.

    The injury also travels up to the brain, triggering a fear response. “People are going to have fear of re‑injury,” Lepley explained, noting the psychological component can cause someone to change movement patterns.

    That’s why, Lepley says, Vonn was likely performing box jumps after the injury. “They’re sort of testing that fear,” Lepley said, noting the exercises can also help fight off muscle inhibition. “If you can’t jump and stabilize yourself on solid ground, that’s a good indication that somebody has too much hesitation.”

    In a video posted on Instagram on Thursday, a day before her completed training run, Vonn squats with weights, lunges from side to side and does fast kicks against a ball.

    How to treat an injured ACL

    Once the ACL is torn, it doesn’t regenerate in the same way that bone does. “Unfortunately, we’re not like lizards,” Lepley said.

    Most people undergo surgery to reconstruct the ligament, and nearly all athletes get the procedure after the injury, according to Roche.

    While a surgical approach doesn’t speed up recovery time, it can stabilize the knee, reduce the risk of further injury and allow for return to high-demanding activities like skiing. Some data suggests surgery can also reduce the risk of osteoarthritis — a common long-term concern after ACL injury — though the evidence is conflicting.

    Regardless of whether someone has surgery, months of rehab are standard. Those who don’t opt for surgery stick to pain control and rehab, learning to live without a functioning ACL.

    Vonn said on Tuesday that surgery “hasn’t been discussed.”

    “It’s not really on my radar screen right now. The Olympics are the only thing that I’m thinking about,” she said. “We’re doing everything to make sure I am making smart and safe decisions.”

    Has anyone ever skied on an injured ACL?

    Yes, some of Vonn’s teammates said they’ve done it. Other skiers, like Slovakian Veronika Velez-Zuzulová have done it, too. And Vonn says she’s done it before.

    “It’s possible,” Roche said. But other parts of the leg need to compensate.

    “When that ligament is gone, your muscles have to step up to help stabilize the joint,” Lepley said.

    All the experts CNN spoke with emphasized that an immediate return to competition is far from the norm — and not recommended. Far more often, athletes do the opposite. Hitting the slopes would expose Vonn to substantial risk of further injury.

    Plus, there was more to her injury. She also reported bone bruising and meniscal damage, both common companions to ACL injuries. These additional injuries raise the risk further, making her return to racing even more dangerous. The good news, though, is that Vonn didn’t report any significant bone fractures, Roche said.

    Roche, who knows Vonn’s medical history well, says it comes down to the athlete.

    “She knows her body better than anyone,” Roche said. “She’ll be able to determine if she can overcome any injury to her knee quickly or if it’s going to set her back.”

    What to watch for when Vonn returns for fresh powder

    Vonn is set to begin racing on Sunday.

    “I don’t think she’s going to be able to perform at 100%,” Lepley said. “But I think she’s going to be able to make the best of a bad situation.”

    Parts of the course that put more stress on one knee could be especially risky. Lepley says the Olympian might lack symmetry as she compensates.

    The biggest concern is Vonn’s meniscus, which acts as a shock absorber and helps the knee move smoothly. Without a functioning ACL, the structure is more vulnerable and, if injured, it’s notoriously difficult to heal.

    At the finish line, three things will matter most, Lepley says: a medical exam to check for any additional damage, close monitoring of pain and swelling and a renewed focus on restoring normal motion and walking. And if her knees are on her side, a medal.

    “She’s in good hands,” Petrosini said. “To be able to pull off what she’s attempting is really remarkable.”

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  • Roche is using AI to find the hardest-to-find lung cancer patients, with a potential blockbuster drug on the line

    Roche is using AI to find the hardest-to-find lung cancer patients, with a potential blockbuster drug on the line

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    Roche Holding AG’s lung cancer drug scored a big win against a standard therapy in a study this week. Now, the Swiss drugmaker is turning to artificial intelligence to find patients who can benefit. 

    When given after surgery to remove lung tumors, Roche’s Alecensa cut the risk of either cancer recurrence or death by 76% compared with standard chemotherapy, according to results from a primary analysis of the trial released Wednesday. The drug could “potentially alter the course of this disease,” Roche Chief Medical Officer Levi Garraway said in a statement. 

    But finding patients to treat may be difficult: The study examined the effects on people with an error in a gene called ALK that’s found in only about 4% to 5% of lung cancer patients. Most of them are younger and less likely to have smoked than typical lung tumor patients, and often go undiagnosed early on. 

    To solve the problem, Roche will use an AI collaboration with Israeli tech company Medial EarlySign Ltd. to help doctors determine when to use CT scans. While the technology, called LungFlag, doesn’t currently detect ALK-positive patients, the company said on Saturday that it’s actively exploring how to expand it so they can benefit. 

    That will help find tumors before they spread and while needed surgery is still possible, said Charlie Fuchs, Roche’s head of oncology and hematology drug development. 

    “Sometimes when you really use deep data algorithms, you may find things that identify people who are non-smokers and yet at risk,” Fuchs said in an interview. “We hope more patients can be found early and benefit from this.”

    Roche has said it will file the Alecensa study results with regulators for approval. The full results were presented Saturday at the European Society for Medical Oncology meeting in Madrid. Alecensa is already approved in the US, Europe, Japan and China for patients with ALK-positive metastatic lung cancer. 

    Analysts anticipate that Alecensa will generate 1.56 billion Swiss francs ($1.75 billion) in sales this year. That it would be a blockbuster medicine even though it treats such a small portion of lung cancer patients shows that effective drugs don’t have to serve a big patient population to be scientific and financial successes, Fuchs said. 

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    Naomi Kresge, Bloomberg

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  • Wall Street ends lower as investors gauge Fed’s policy path; Nasdaq loses over 1%

    Wall Street ends lower as investors gauge Fed’s policy path; Nasdaq loses over 1%

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    Wall Street’s main indexes ended lower on Monday, with real estate and discretionary sectors leading broad declines, as investors digested comments from US Federal Reserve officials about plans for interest rate hikes and looked for next catalysts after last week’s big stock market rally.

    Losses accelerated toward the end of the up-and-down session, with the focus turning to Tuesday’s producer price index report and markets highly sensitive to inflation data.

    Earlier on Monday, Fed Vice Chair Lael Brainard signaled that the central bank would will likely soon slow its interest rates hikes. Her comments somewhat buoyed sentiment for equities that had been dampened after Federal Reserve Gov. Christopher Waller on Sunday said the Fed may consider slowing the pace of increases at its next meeting but that should not be seen as a “softening” in its commitment to lower inflation.

    A massive equity rally late last week was set off by a softer-than-expected inflation report that boosted investor hopes the Fed could dial back on its monetary tightening that has punished markets this year.

    “There is still a sensitivity to Fed speak… One was a little hawkish, one was a little dovish,” said Eric Kuby, chief investment officer at North Star Investment Management Corp.

    The Dow Jones Industrial Average fell 211.16 points, or 0.63%, to 33,536.7, the S&P 500 lost 35.68 points, or 0.89%, to 3,957.25 and the Nasdaq Composite dropped 127.11 points, or 1.12%, to 11,196.22.

    The S&P 500 last week posted its biggest weekly percentage gain since late June, while the tech-heavy Nasdaq notched its best week since March.

    More Fed officials are due to speak later this week along with a slew of data, including on retail sales and housing, and earnings reports from major retailers.

    “It just makes sense the market wants to pause and really both try to make sense of the trajectory (of Fed policy) and what the next drivers are going to be,” said Yung-Yu Ma, chief investment strategist at BMO Wealth Management.

    Among S&P 500 sectors, real estate fell 2.7%, consumer discretionary dropped 1.7% and financials declined 1.5%.

    In company news, Amazon shares fell 2.3% as The New York Times on Monday reported the company was planning to lay off about 10,000 people in corporate and technology jobs starting as soon as this week.

    Shares of Biogen Inc and Eli Lilly gained 3.3% and 1.3%, respectively, after the failure of Swiss rival Roche’s Alzheimer’s disease drug candidate.

    Declining issues outnumbered advancing ones on the NYSE by a 2.23-to-1 ratio; on Nasdaq, a 1.61-to-1 ratio favored decliners.

    The S&P 500 posted 15 new 52-week highs and 2 new lows; the Nasdaq Composite recorded 72 new highs and 74 new lows.

    About 11.5 billion shares changed hands in US exchanges, compared with the 12.1 billion daily average over the last 20 sessions.

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