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  • Who’s going to pay for an ethical chocolate bar?

    Who’s going to pay for an ethical chocolate bar?

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    Europe, the world’s biggest consumer of chocolate, and West Africa, the leading grower of the cocoa beans used to make it, share a common goal to make the sector sustainable.

    But they have opposing views on how to put an end to the social, economic and environmental harms caused by satisfying Europe’s sweet tooth, heralding a showdown over who will bear the costs of complying: Big Chocolate or cocoa farmers.

    The EU is finalizing regulations that seek to ensure that chocolate entering the market is free from deforestation and child labor. At the same time, Ghana and Ivory Coast, the world’s biggest cocoa producers, are demanding higher prices. That’s vital, they say, to make sustainable chocolate a possibility — and not a pipe dream.

    The stakes are high: For the EU, cocoa is a test case for how companies and producers react when the bloc tries to impose higher standards. For producers, the push to set up a cartel could drive up prices in the short term — but also risks stimulating oversupply and ultimately causing a price crash that would deepen the poverty already suffered by most cocoa farmers. Chocolate makers, facing rising costs and greater scrutiny, may reroute supply chains to other cocoa-producing countries seen as less risky.

    Doing nothing is not an option, said Alex Assanvo, who heads the joint West African initiative to support cocoa prices.

    “We are not asking to pay them more, we are asking to pay them a fair price,” Assanvo told POLITICO in an interview. “If we believe that this is going to create oversupply, well then I don’t know, maybe we should stop eating chocolate.”

    Bittersweet taste

    Chocolate may be sweet but the industry that makes it is not. Most of the beans used to produce the world’s supply are grown by impoverished West African farmers; all too often from trees planted on deforested land and harvested by children. One problem drives the others. Poverty pushes farmers to chop down forests to produce more beans and profits and to put children to work as they cannot afford to pay wages to adult laborers.

    To address this, Ghana and Ivory Coast, which produce 60 percent of the world’s cocoa, formed an export cartel in 2019 modeled on the Organization of the Petroleum Exporting Countries (OPEC). They introduced a $400 per ton Living Income Differential, which aims to bring the floor price up enough to cover the cost of production.

    In public, big chocolate manufacturers and traders, including Barry Callebaut, Cargill, Ferrero, Hersey, Lindt, Mars, Mondelez and Nestlé, welcomed the initiative.

    Yet behind the scenes many of the firms — which between them account for about 90 percent of the industry’s $130 billion in annual profits — have done everything possible to avoid paying the premium and to drive prices back down, according to the Ivorian Coffee-Cocoa Council (CCC), the Ghana Cocoa Board (Cocobod) and their joint Initiative Cacao Ivory Coast-Ghana (ICCIG).

    The companies that responded to requests for comment from POLITICO said that they have paid the Living Income Differential (LID) since its introduction. The Ghanian and Ivorian trade boards and the ICCIG claim, however, that they have negated the LID’s value by forcing down a different premium, the origin differential.

    Fed up, these countries boycotted the World Cocoa Foundation Partnership Meeting at the end of October in Brussels. They then gave the companies a deadline: commit to the premiums by November 20 or the countries would ban their buyers from visiting fields to carry out harvest forecasts and suspend their Corporate Social Responsibility programs – which sell well with ethically-minded consumers.

    More harm than good?

    Another proposed remedy comes from Brussels. Cocoa is one of the products to which the new EU legislation on due diligence — Brussels speak for supply-chain oversight and compliance — would apply.

    Under this, large firms operating in the bloc will be forced to evaluate their global supply chains for human rights and environmental abuses, and compensate injured parties. In theory, this should reduce deforestation and child labor and improve the lot of farmers.

    Yet, as European ambassadors thrash out the terms — and big players like France push for them to be watered down — concerns are growing that the legislation could turn out at best to be ineffective in practice, and at worst do more harm than good.

    Cocoa farmers, and the NGOs that support them, have reason to be skeptical: Back in 2000, a BBC documentary exposed the widespread use of child labor on cocoa plantations in Ivory Coast and Ghana. The resulting media pressure led to a proposal for legislation in the United States forcing companies to certify chocolate bars free of child labor.

    Companies pushed back hard, Antonie Fountain, managing director of cocoa NGO coalition The Voice Network, told POLITICO. The proposal was dropped and companies committed instead to a voluntary plan to solve child labor, he explained: “And that turned into a two-decade failure of policy.”

    The resulting patchwork of pilot projects failed to transform the sector. Despite an initial decline, nearly 20 years after the framework was introduced 790,000 children in Ivory Coast and 770,000 in Ghana are still working in cocoa, with 95 percent of them exposed to the worst forms of child labor, according to a 2020 report.

    Deforestation has meanwhile accelerated.

    Ivory Coast has lost up to 90 percent of its forest in the last half century. Between 2000 and 2019 alone 2.4 million hectares of forest was cleared for cocoa farms, representing 45 percent of the total deforestation and forest degradation in the country, according to Trase, a data-driven transparency initiative.

    The government’s attempts to safeguard what remains are half-hearted and often undermined by corruption: In 2019 a quarter of Ivory Coast’s cocoa production was in protected areas and forest reserves, the Trase study found. This left the EU exposed to 838,000 hectares of deforestation from Ivorian cocoa. Commodity trader Cargill leads the pack, according to Trase, with its 2019 exports exposed to 183,000 hectares of deforestation.

    Over the last decade companies have proposed corporate social responsibility (CSR) initiatives that aim to tackle both ills. For instance, Mondelez, the maker of Cadbury and Toblerone, recently committed $600 million to tackle deforestation and forced labor in cocoa-producing countries, bringing its total funding for environmental and social issues to $1 billion since 2010.

    These sums are, however, puny by comparison with the profits earned by those firms, said Fountain. Mondelez returned $2.5 billion to investors in the first half of 2022. 

    Mondelez is “excited” about its investments, the firm said in a statement. But it is calling for more sector-wide actions and rethinking its incentive model. Cargill did not respond to a request for comment.

    Social responsibility

    The big numbers that companies cite about their CSR programs’ reach often boil down to one-off training sessions on productivity for farmers, Uwe Gneiting, senior researcher at Oxfam, told POLITICO. This was the case for 98 percent of the 400 farmers interviewed for research recently carried out by Gneiting and others from the charity into the impact of sustainability programs over the last decade in Ghana on farmers’ incomes.

    The research finds that CSR initiatives, which companies use to tout their sustainability credentials to European consumers, have not meaningfully increased farmers’ productivity or profits, pointed out Gneiting. In fact, farmers end up shouldering the associated costs, because companies offer the training but do not pay for extra labor or the fertilizer that farmers need to put it into action.

    Instead, Ghanian and Ivorian farmers have been hammered by the soaring cost of production and of living over the last three years, finds the new Oxfam research. Fertilizer costs have increased by more than 200 percent, said Gneiting, along with labor and transportation costs. That in turn has contributed to a decline in yields that have also been hurt by climate change, with weather patterns becoming increasingly unpredictable.

    All of this has meant incomes have declined close to 20 percent since 2019, said Gneiting, which for farmers already living on the poverty line is “existential.” The decline would have been much worse, he added, if it hadn’t been for the Living Income Differential. Nonetheless, 90 percent of the farmers interviewed say they are worse off than three years ago.

    Over the same period, as cocoa prices have fallen, companies have made “windfall gains,” said Isaac Gyamfi, director of Solidaridad West Africa. “The raw material became cheaper for them. But the price of chocolate didn’t change.”

    Can Brussels sort it out?

    To what extent the new due diligence directive will make a difference depends on the final text that was put to a meeting of EU trade ministers on Friday.

    When the European Commission first came up with the draft it was seen as a game changer, but subsequent wrangling over the regulation’s scope has raised doubts. Last week, ambassadors from France, Spain, Italy and some smaller countries voted down the text in the European Council, seeing the value chain and civil liability provisions as too wide and too ambitious.

    Two-thirds of Ivorian cocoa is exported to the EU and the U.K. | Issouf Sanogo/AFP via Getty Images

    A European diplomat told POLITICO that France supported the proposed directive “very strongly,” and its view that it was important to concentrate on the “upstream” part of the supply chain was shared by a majority of EU member countries.

    NGOs take the view that, while it’s positive that the EU is proposing broad legislation, there is a risk that it ends up replicating the mistakes that undermined the voluntary initiatives. One of these is the potential limitation of the companies’ due diligence obligations to “established business relations.”

    “What you’re going to get is a whole bunch of companies that are going to try to have as few established business relations as possible, which just makes supplying commodities more precarious, rather than less,” said Fountain.

    Analysis from Trase finds that 55 percent of Ivorian cocoa, two-thirds of which is exported to the EU and the U.K., comes from untraceable sources. NGOs working on cocoa and on other sectors due to be impacted by the new directive are calling for it to be applied to business relationships based on their risk rather than their duration.

    The civil liability mechanism, which should guarantee compensation for people whose rights have been violated, has also come under scrutiny. The latest compromise proposal debated in the Council, seen by POLITICO, reduces the risk of companies getting sued by stipulating that a company can only be held liable if it “intentionally or negligently” failed to comply with a due diligence obligation aimed to protect a “natural or legal person” — not a forest, for instance — and subsequently caused damage to that person’s “legal interest protected under national law.” But, it states, a company cannot be held liable “if the damage was caused only by its business partners in its chain of activities.”

    Earlier this year, the EU, Ivory Coast and Ghana and the cocoa sector all committed to a roadmap to make cocoa more sustainable, which, they agreed, includes improving farmers’ incomes. Yet it remains unclear whether this will be mentioned in the final draft of the due diligence directive.

    “Sustainability cannot exist without a living income,” said Heidi Hautala, Green MEP and chair of the European Parliament’s Responsible Business Conduct Working Group. Hautala, who is among those pushing for the reference to a living income to be included in the final text, added that responsible purchasing practices are “a prerequisite for respect of human rights, environment and climate.”

    Living income “needs to be a part of it because otherwise you’re in trouble,” agreed Fountain.

    “If you don’t look at what does a farmer need in order to comply, if you don’t make sure that a farmer actually has the right set of income, then all you’re doing is pushing the responsibility for being sustainable back to the farmer. And this is what we’ve done for the last two decades.”

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    POLITICO Staff

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  • Stop the killer robots! Musk-backed lobbyists fight to save Europe from bad AI

    Stop the killer robots! Musk-backed lobbyists fight to save Europe from bad AI

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    A lobby group backed by Elon Musk and associated with a controversial ideology popular among tech billionaires is fighting to prevent killer robots from terminating humanity, and it’s taken hold of Europe’s Artificial Intelligence Act to do so.

    The Future of Life Institute (FLI) has over the past year made itself a force of influence on some of the AI Act’s most contentious elements. Despite the group’s links to Silicon Valley, Big Tech giants like Google and Microsoft have found themselves on the losing side of FLI’s arguments.

    In the EU bubble, the arrival of a group whose actions are colored by fear of AI-triggered catastrophe rather than run-of-the-mill consumer protection concerns was received like a spaceship alighting in the Schuman roundabout. Some worry that the institute embodies a techbro-ish anxiety about low-probability threats that could divert attention from more immediate problems. But most agree that during its time in Brussels, the FLI has been effective. 

    “They’re rather pragmatic and they have legal and technical expertise,” said Kai Zenner, a digital policy adviser to center-right MEP Axel Voss, who works on the AI Act. “They’re sometimes a bit too worried about technology, but they raise a lot of good points.” 

    Launched in 2014 by MIT academic Max Tegmark and backed by tech grandees including Musk, Skype’s Jaan Tallinn, and crypto wunderkind Vitalik Buterin, FLI is a nonprofit devoted to grappling with “existential risks” — events able to wipe out or doom humankind. It counts other hot shots like actors Morgan Freeman and Alan Alda and renowned scientists Martin (Lord) Rees and Nick Bostrom among its external advisers.

    Chief among those menaces — and FLI’s priorities — is artificial intelligence running amok.

    “We’ve seen plane crashes because an autopilot couldn’t be overruled. We’ve seen a storming of the U.S. Capitol because an algorithm was trained to maximize engagement. These are AI safety failures today — as these systems become more powerful, harms might become worse,” Mark Brakel, FLI director of European policy, said in an interview.

    But the lobby group faces two PR problems. First, Musk, its most famous backer, is at the center of a storm since he started mass firings at Twitter as its new owner, catching the eye of regulators, too. Musk’s controversies could cause lawmakers to get skittish about talking to FLI. Second, the group’s connections to a set of beliefs known as effective altruism are raising eyebrows: The ideology faces a reckoning and is most recently being blamed as a driving force behind the scandal around cryptocurrency exchange FTX, which has unleashed financial carnage. 

    How FLI pierced the bubble

    The arrival of a lobby group fighting off extinction, misaligned artificial intelligence and killer robots was bound to be refreshing to otherwise snoozy Brussels policymaking.

    FLI’s Brussels office opened in mid-2021, as discussions about the European Commission’s AI Act proposal were kicking off.

    “We would prefer AI to be developed in Europe, where there will be regulations in place,” Brakel said. “The hope is that people take inspiration from the EU.”

    A former diplomat, the Dutch-born Brakel joined the institute in May 2021. He chose to work in AI policy as a field that was both impactful and underserved. Policy researcher Risto Uuk joined him two months later. A skilled digital operator — he publishes his analyses and newsletter from the domain artificialintelligenceact.eu — Uuk had previously done AI research for the Commission and the World Economic Forum. He joined FLI out of philosophical affinity: like Tegmark, Uuk subscribes to the tenets of effective altruism, a value system prescribing the use of hard evidence to decide how to benefit the largest number of people.

    Since starting in Brussels, the institute’s three-person team (with help from Tegmark and others, including law firm Dentons) has deftly spearheaded lobbying efforts on little-known AI issues.

    Elon Musk is one of the Future of Life Institute’s most prominent backers | Carina Johansen/NTB/AFP via Getty Images

    Exhibit A: general-purpose AI — software like speech-recognition or image-generating tools used in a vast array of contexts and sometimes affected by biases and dangerous inaccuracies (for instance, in medical settings). General-purpose AI was not mentioned in the Commission’s proposal, but wended its way into the EU Council’s final text and is guaranteed to feature in Parliament’s position.

    “We came out and said, ‘There’s this new class of AI — general-purpose AI systems — and the AI Act doesn’t consider them whatsoever. You should worry about this,'” Brakel said. “This was not on anyone’s radar. Now it is.”

    The group is also playing on European fears of technological domination by the U.S. and China. “General-purpose AI systems are built mainly in the U.S. and China, and that could harm innovation in Europe, if you don’t ensure they abide by some requirements,” Brakel said, adding this argument resonated with center-right lawmakers with whom he recently met. 

    Another of FLI’s hobbyhorses is outlawing AI able to manipulate people’s behavior. The original proposal bans manipulative AI, but that is limited to “subliminal” techniques — which Brakel thinks would create loopholes. 

    But the AI Act’s co-rapporteur, Romanian Renew lawmaker Dragoș Tudorache, is now pushing to make the ban more comprehensive. “If that amendment goes through, we would be a lot happier than we are with the current text,” Brakel said.

    So smart it made crypto crash

    While the group’s input on key provisions in the AI bill was welcomed, many in Brussels’ establishment look askance at its worldview.

    Tegmark and other FLI backers adhere to what’s referred to as effective altruism (or EA). A strand of utilitarianism codified by philosopher William MacAskill — whose work Musk called “a close match for my philosophy” — EA dictates that one should better the lives of as many people as possible, using a rationalist fact-based approach. At a basic level, that means donating big chunks of one’s income to competent charities. A more radical, long-termist strand of effective altruism demands that one strive to minimize risks able to kill off a lot of people — and especially future people, who will greatly outnumber existing ones. That means that preventing the potential rise of an AI whose values clash with humankind’s well-being should be at the top of one’s list of concerns.

    A critical take on FLI is that it is furthering this interpretation of the so-called effective altruism agenda, one supposedly uninterested in the world’s current ills — such as racism, sexism and hunger — and focused on sci-fi threats to yet-to-be-born folks. Timnit Gebru, an AI researcher whose acrimonious exit from Google made headlines in 2020, has lambasted FLI on Twitter, voicing “huge concerns” about it.

    “They are backed by billionaires including Elon Musk — that already should make people suspicious,” Gebru said in an interview. “The entire field around AI safety is made up of so many ‘institutes’ and companies billionaires pump money into. But their concept of AI safety has nothing to do with current harms towards marginalized groups — they want to reorient the entire conversation into preventing this AI apocalypse.”

    Effective altruism’s reputation has taken a hit in recent weeks after the fall of FTX, a bankrupt exchange that lost at least $1 billion in customers’ cryptocurrency assets. Its disgraced CEO Sam Bankman-Fried used to be one of EA’s darlings, talking in interviews about his plan to make bazillions and give them to charity. As FTX crumbled, commentators argued that Effective Altruism ideology led Bankman-Fried to cut corners and rationalize his recklessness. 

    Both MacAskill and FLI donor Buterin defended EA on Twitter, saying that Bankman-Fried’s actions contrasted with the philosophy’s tenets. “Automatically downgrading every single thing SBF believed in is an error,” wrote Buterin, who invented the Ethereum blockchain, and bankrolls FLI’s scholarship for AI existential risk research.

    Brakel said that the FLI and EA were two distinct things, and FLI’s advocacy was focused on present problems, from biased software to autonomous weapons, e.g. at the United Nations level. “Do we spend a lot of time thinking about what the world would look like in 400 years? No,” he said. (Neither Brakel nor the FLI’s EU representative, Claudia Prettner, call themselves effective altruists.)

    Californian ideology

    Another critique of FLI’s efforts to stave off evil AI argues that they obscure a techno-utopian drive to develop benevolent human-level AI. At a 2017 conference, FLI advisers — including Musk, Tegmark and Skype’s Tallinn — debated the likelihood and the desirability of smarter-than-human AI. Most panelists deemed “superintelligence” bound to happen; half of them deemed it desirable. The conference’s output was a series of (fairly moderate) guidelines on developing beneficial AI, which Brakel cited as one of FLI’s foundational documents.

    That techno-optimism led Emile P. Torres, a Ph.D. candidate in philosophy who used to collaborate with FLI, to ultimately turn against the organization. “None of them seem to consider that maybe we should explore some kind of moratorium,” Torres said. Raising such points with an FLI staffer, Torres said, led to a sort of excommunication. (Torres’s articles have been taken down from FLI’s website.)

    Within Brussels, the worry is that going ahead, FLI might change course from its current down-to-earth incarnation and steer the AI debate toward far-flung scenarios. “When discussing AI at the EU level, we wanted to draw a clear distinction between boring and concrete AI systems and sci-fi questions,” said Daniel Leufer, a lobbyist with digital rights NGO Access Now. “When earlier EU discussions on AI regulation happened, there were no organizations in Brussels placing focus on topics like superintelligence — it’s good that the debate didn’t go in that direction.”

    Those who regard the FLI as the spawn of Californian futurism point to its board and its wallet. Besides Musk, Tallinn and Tegmark, donors and advisers include researchers from Google and OpenAI, Meta co-founder Dustin Moskovitz’s Open Philanthropy, the Berkeley Existential Risk Initiative (which in turn has received funding from FTX) and actor Morgan Freeman. 

    In 2020 most of FLI’s global funding ($276,000 out of $482,479) came from the Silicon Valley Community Foundation, a charity favored by tech bigwigs like Mark Zuckerberg; 2021 accounts haven’t been released yet. 

    Brakel denied that the FLI is cozy with Silicon Valley, saying that the organization’s work on general-purpose AI made life harder for tech companies. Brakel said he had never spoken to Musk. Tegmark, meanwhile, is in regular touch with the members of the scientific advisory board, which includes Musk. 

    In Brakel’s opinion, what the FLI is doing is akin to early-day climate activism. “We currently see the warmest October ever. We worry about it today, but we also worry about the impact in 80 years’ time,” he said last month. “[There] are AI safety failures today — and as these systems become more powerful, the harms might become worse.”

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    Gian Volpicelli

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  • GSK Says Dreamm-3 Phase 3 Study For Blenrep Didn’t Meet Primary Endpoint

    GSK Says Dreamm-3 Phase 3 Study For Blenrep Didn’t Meet Primary Endpoint

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    By Michael Susin

    GSK PLC said Monday that its Dreamm-3 Phase 3 study in patients with relapsed or refractory multiple myeloma didn’t meet its primary endpoint of progression-free survival.

    The pharmaceutical giant said that the study compared its monotherapy Blenrep versus pomalidomide in combination with low dose dexamethasone and observed median progression-free survival was longer for Blenrep.

    “These trials are designed to demonstrate the benefit of Blenrep in combination treatment with novel therapies and standard-of-care treatments in earlier lines of therapy and dosing optimization to maintain efficacy while reducing corneal events,” it added.

    The company said additional trials will continue and further data from the studies are anticipated in the first half of 2023.

    Write to Michael Susin at michael.susin@wsj.com

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  • Where Britain went wrong

    Where Britain went wrong

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    LIVERPOOL, England — On the long picket line outside the gates of Liverpool’s Peel Port, rain-soaked dock workers warm themselves with cups of tea as they listen to 1980s pop.

    Dozens of buses, cars and trucks honk in solidarity as they pass.

    Dockers’ strikes are not new to Liverpool, nor is depravation. But this latest walk-out at Britain’s fourth-largest port is part of something much bigger, a great wave of public and private sector strikes taking place across the U.K. Railways, postal services, law courts and garbage collections are among the many public services grinding to a halt.

    The immediate cause of the discontent, as elsewhere, is the rising cost of living. Inflation in the United Kingdom breached the 10 percent mark this year, with wages failing to keep pace.

    But the U.K.’s economic woes long predate the current crisis. For more than a decade, Britain has been beset by weak economic growth, anaemic productivity, and stagnant private and public sector investment. Since 2016, its political leadership has been in a state of Brexit-induced flux.

    Half a century after U.S. Secretary of State Henry Kissinger looked at the U.K.’s 1970s economic malaise and declared that “Britain is a tragedy,” the United Kingdom is heading to be the sick man of Europe once again.

    The immediate cause of Liverpool dockers’ discontent that brought them to strike is the rising cost of living. | Christopher Furlong/Getty Images

    Here in Liverpool, the “scars run very deep,” said Paul Turking, a dock worker in his late 30s. British voters, he added, have “been misled” by politicians’ promises to “level up” the country by investing heavily in regional economies. Conservatives “will promise you the world and then pull the carpet out from under your feet,” he complained.

    “There’s no middle class no more,” said John Delij, a Peel Port veteran of 15 years. He sees the cost-of-living crisis and economic stagnation whittling away the middle rung of the economic ladder.

    “How many billionaires do we have?” Delij asked, wondering how Britain could be the sixth-largest economy in the world with a record number of billionaires when food bank use is 35 percent above its pre-pandemic level. “The workers put money back into the economy,” he said.

    What would they do if they were in charge? “Invest in affordable housing,” said Turking. “Housing and jobs.”

    Falling behind

    The British economy has been struck by particular turbulence over recent weeks. The cost of government borrowing soared in the wake of former PM Liz Truss’ disastrous mini-budget on September 23, with the U.K.’s central bank forced to step in and steady the bond markets.

    But while the swift installation of Rishi Sunak, the former chancellor, as prime minister seems to have restored a modicum of calm, the economic backdrop remains bleak. Spending and welfare cuts are coming. Taxes are certain to rise. And the underlying problems cut deep.

    U.K. productivity growth since the financial crisis has trailed that of comparator nations such as the U.S., France and Germany. As such, people’s median incomes also lag behind neighboring countries over the same period. Only Russia is forecast to have worse economic growth among the G20 nations in 2023.

    In 1976, the U.K. — facing stagflation, a global energy crisis, a current account deficit and labor unrest — had to be bailed out by the International Monetary Fund. It feels far-fetched, but today some are warning it could happen again.

    The U.K. is spluttering its way through an illness brought about in part through a series of self-inflicted wounds that have undermined the basic pillars of any economy: confidence and stability. 

    The political and economic malaise is such that it has prompted unwanted comparisons with countries whose misfortunes Britain once watched amusedly from afar.

    “The existential risk to the U.K. … is not that we’re suddenly going to go off an economic cliff, or that the country’s going to descend into civil war or whatever,” said Jonathan Portes, professor of economics at King’s College London. “It’s that we will become like Italy.”

    Portes, of course, does not mean a country blessed with good weather and fine food — but an economy hobbled by persistently low growth, caught in a dysfunctional political loop that lurches between “corrupt and incompetent right-wing populists” and “well-intentioned technocrats who can’t actually seem to turn the ship around.” 

    “That’s not the future that we want in the U.K,” he said.

    Reviving the U.K.’s flatlining economy will not happen overnight. As Italy’s experience demonstrates, it’s one thing to diagnose an illness — another to cure it.

    Experts speak of an unbalanced model heavily reliant upon Britain’s services sector and beset with low productivity, a result of years of underinvestment and a flexible labor market which delivers low unemployment but often insecure and low-paid work.

    “We’re not investing in skills; businesses aren’t investing,” said Xiaowei Xu, senior research economist at the Institute for Fiscal Studies. “It’s not that surprising that we’re not getting productivity growth.”

    But any attempt to address the country’s ailments will require its economic stewards to understand their underlying causes — and those stretch back at least to the first truly global crisis of the 21st century. 

    Crash and burn

    The 2008 financial crisis hammered economies around the world, and the U.K. was no exception. Its economy shrunk by more than 6 percent between the first quarter of 2008 and the second quarter of 2009. Five years passed before it returned to its pre-recession size.

    For Britain, the crisis in fact began in September 2007, a year before the collapse of Lehman Brothers, when wobbles in the U.S. subprime mortgage market sparked a run on the British bank Northern Rock.

    The U.K. discovered it was particularly vulnerable to such a shock. Over the second half of the 20th century, its manufacturing base had largely eroded as its services sector expanded, with financial and professional services and real estate among the key drivers. As the Bank of England put it: “The interconnectedness of global finance meant that the U.K. financial system had become dangerously exposed to the fall-out from the U.S. sub-prime mortgage market.”

    The crisis was a “big shock to the U.K.’s broad economic model,” said John Springford, from the Centre for European Reform. Productivity took an immediate hit as exports of financial services plunged. It never fully recovered.

    “Productivity before the crash was basically, ‘Can we create lots and lots of debt and generate lots and lots of income on the back of this? Can we invent collateralized debt obligations and trade them in vast volumes?’” said James Meadway, director of the Progressive Economy Forum and a former adviser to Labour’s left-wing former shadow chancellor, John McDonnell.

    A post-crash clampdown on City practises had an obvious impact.

    “This is a major part of the British economy, so if it’s suddenly not performing the way it used to — for good reasons — things overall are going to look a bit shaky,” Meadway added.

    The shock did not contain itself to the economy. In a pattern that would be repeated, and accentuated, in the coming years, it sent shuddering waves through the country’s political system, too.

    The 2010 election was fought on how to best repair Britain’s broken economy. In 2009, the U.K. had the second-highest budget deficit in the G7, trailing only the U.S., according to the U.K. government’s own fiscal watchdog, the Office for Budget Responsibility (OBR).

    The Conservative manifesto declared “our economy is overwhelmed by debt,” and promised to close the U.K.’s mounting budget deficit in five years with sharp public sector cuts. The incumbent Labour government responded by pledging to halve the deficit by 2014 with “deeper and tougher” cuts in public spending than the significant reductions overseen by former Conservative Prime Minister Margaret Thatcher in the 1980s.  

    The election returned a hung parliament, with the Conservatives entering into a coalition with the Liberal Democrats. The age of austerity was ushered in.

    Austerity nation

    Defenders of then-Chancellor George Osborne’s austerity program insist it saved Britain from the sort of market-led calamity witnessed this fall, and put the U.K. economy in a condition to weather subsequent global crises such as the COVID-19 pandemic and the fallout from the war in Ukraine.

    “That hard work made policies like furlough and the energy price cap possible,” said Rupert Harrison, one of Osborne’s closest Treasury advisers.

    Pointing to the brutal market response to Truss’ freewheeling economic plans, Harrison praised the “wisdom” of the coalition in prioritizing tackling the U.K.’s debt-GDP ratio. “You never know when you will be vulnerable to a loss of credibility,” he noted.

    But Osborne’s detractors argue austerity — which saw deep cuts to community services such as libraries and adult social care; courts and prisons services; road maintenance; the police and so much more — also stripped away much of the U.K.’s social fabric, causing lasting and profound economic damage. A recent study claimed austerity was responsible for hundreds of thousands of excess deaths.

    Under Osborne’s plan, three-quarters of the fiscal consolidation was to be delivered by spending cuts. With the exception of the National Health Service, schools and aid spending, all government budgets were slashed; public sector pay was frozen; taxes (mainly VAT) rose.

    But while the government came close to delivering its fiscal tightening target for 2014-15, “the persistent underperformance of productivity and real GDP over that period meant the deficit remained higher than initially expected,” the OBR said. By his own measure, Osborne had failed, and was forced to push back his deficit-elimination target further. Austerity would have to continue into the second half of the 2010s.

    Many economists contend that the fiscal belt-tightening sucked demand out of the economy and worsened Britain’s productivity crisis by stifling investment. “That certainly did hit U.K. growth and did some permanent damage,” said King’s College London’s Portes.

    “If that investment isn’t there, other people start to find it less attractive to open businesses,” former Labour aide Meadway added. “If your railways aren’t actually very good … it does add up to a problem for businesses.”

    A 2015 study found U.K. productivity, as measured by GDP per hour worked, was now lower than in the rest of the G7 by a whopping 18 percentage points. 

    “Frankly, nobody knows the whole answer,” Osborne said of Britain’s productivity conundrum in May 2015. “But what I do know is that I’d much rather have the productivity challenge than the challenge of mass unemployment.”

    ‘Jobs miracle’

    Rising employment was indeed a signature achievement of the coalition years. Unemployment dropped below 6 percent across the U.K. by the end of the parliament in 2015, with just Germany and Austria achieving a lower rate of joblessness among the then-28 EU states. Real-term wages, however, took nearly a decade to recover to pre-crisis levels. 

    Economists like Meadway contend that the rise in employment came with a price, courtesy of Britain’s famously flexible labor market. He points to a Sports Direct warehouse in the East Midlands, where a 2015 Guardian investigation revealed the predominantly immigrant workforce was paid illegally low wages, while the working conditions were such that the facility was nicknamed “the gulag.”

    The warehouse, it emerged, was built on a former coal mine, and for Meadway the symbolism neatly charts the U.K.’s move away from traditional heavy industry toward more precarious service sector employment. “It’s not a secure job anymore,” he said. “Once you have a very flexible labor market, the pressure on employers to pay more and the capacity for workers to bargain for more is very much reduced.”

    Throughout the period, the Bank of England — the U.K.’s central bank — kept interest rates low and pursued a policy of quantitative easing. “That tends to distort what happens in the economy,” argued Meadway. QE, he said, is a “good [way of] getting money into the hands of people who already have quite a lot” and “doesn’t do much for people who depend on wage income.”

    Meanwhile — whether necessary or not — the U.K.’s austerity policies undoubtedly worsened a decades-long trend of underinvestment in skills and research and development (Britain lags only Italy in the G7 on R&D spending). At British schools, there was a 9 percent real terms fall in per-pupil spending between 2009 and 2019, according to the Institute for Fiscal Studies’ Xu. “As countries get richer, usually you start spending more on education,” Xu noted.

    Two senior ministers in the coalition government — David Gauke, who served in the Treasury throughout Osborne’s tenure, and ex-Lib Dem Business Secretary Vince Cable — have both accepted that the government might have focused more on higher taxation and less on cuts to public spending. But both also insisted the U.K had ultimately been correct to prioritize putting its public finances on a sounder footing.

    It was February 2018 before Britain finally achieved Osborne’s goal of eliminating the deficit on its day-to-day budget.

    Austerity was coming to an end, at last. But Osborne had already left the Treasury, 18 months earlier — swept away along with Cameron in the wake of a seismic national uprising. 

    ***

    David Cameron had won the 2015 election outright, despite — or perhaps because of — the stringent spending cuts his coalition government had overseen, more of which had been pledged in his 2015 manifesto. Also promised, of course, was a public vote on Britain’s EU membership.

    The reasons for the leave vote that followed were many and complex — but few doubt that years of underinvestment in poorer parts of the U.K. were among them.

    Regardless, the 2016 EU referendum triggered a period of political acrimony and turbulence not seen in Westminster for generations. With no pre-agreed model of what Brexit should actually entail, the U.K.’s future relationship with the EU became the subject of heated and protracted debate. After years of wrangling, Britain finally left the bloc at the end of January 2020, severing ties in a more profound way than many had envisaged.

    While the twin crises of COVID and Ukraine have muddled the picture, most economists agree Brexit has already had a significant impact on the U.K. economy. The size of Britain’s trade flows relative to GDP has fallen further than other G7 countries, business investment growth trails the likes of Japan, South Korea and Italy, and the OBR has stuck by its March 2020 prediction that Brexit would reduce productivity and U.K. GDP by 4 percent.

    Perhaps more significantly, Brexit has ushered in a period of political instability. As prime ministers come and go (the U.K. is now on its fifth since 2016), economic programs get neglected, or overturned. Overseas investors look on with trepidation.

    “The evidence that the referendum outcome, and the kind of uncertainty and change in policy that it created, have led to low investment and low growth in the U.K. is fairly compelling,” said professor Stephen Millard, deputy director at the National Institute of Economic and Social Research.

    Beyond the instability, the broader impact of the vote to leave remains contentious.

    Portes argued — as many Remain supporters also do — that much harm was done by the decision to leave the EU’s single market. “It’s the facts, not the uncertainty that in my view is responsible for most of the damage,” he said.

    Brexit supporters dismiss such claims.

    “It’s difficult statistically to find much significant effect of Brexit on anything,” said professor Patrick Minford, founder member of Economists for Brexit. “There’s so much else going on, so much volatility.”

    Minford, an economist favored by ex-PM Truss, acknowledged that “Brexit is disruptive in the short run, so it’s perfectly possible that you would get some short-run disruption.” But he added: “It was a long-term policy decision.”

    Where next?

    Plenty of economists can rattle off possible solutions, although actually delivering them has thus far evaded Britain’s political class. “It’s increasing investment, having more of a focus on the long-term, it’s having economic strategies that you set out and actually commit to over time,” says the IFS’ Xu. “As far as possible, it’s creating more certainty over economic policy.”

    But in seeking to bring stability after the brief but chaotic Truss era, new U.K. Chancellor Jeremy Hunt has signaled a fresh period of austerity is on the way to plug the latest hole in the nation’s finances. Leveling Up Secretary Michael Gove told Times Radio that while, ideally, you wouldn’t want to reduce long-term capital investments, he was sure some spending on big projects “will be cut.”

    This could be bad news for many of the U.K.’s long-awaited infrastructure schemes such as the HS2 high-speed rail line, which has been in the works for almost 15 years and already faces a familiar mix of local resistance, vested interests, and a sclerotic planning system.

    “We have a real problem in the sense that the only way to really durably raise productivity growth for this country is for investments to pick up,” said Springford, from the Centre for European Reform. “And the headwinds to that are quite significant.”

    For dock workers at Liverpool’s Peel Port, the prospect of a fresh round of austerity amid a cost-of-living crisis is too much to bear. “Workers all over this country need to stand up for themselves and join a union,” insisted Delij.

    For him, it’s all about priorities — and the arguments still echo back to the great crash of 15 years ago. “They bailed the bankers out in 2007,” he said, “and can’t bail hungry people out now.”

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    Sebastian Whale and Graham Lanktree

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  • Weird Facts

    Weird Facts

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    According to Science, Laziness can be a sign of high intelligence.

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  • Britain wants an election. It’s not getting one

    Britain wants an election. It’s not getting one

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    LONDON — Now on their third prime minister since the last general election, the despairing British public want a vote on who runs the country. They appear to be out of luck.

    New U.K. premier Rishi Sunak did not secure the 2019 election win for the Tories. Neither did his predecessor Liz Truss, who instead for a chaotic 44 days tried to rip up many of the economic and policy promises in Conservative manifesto.

    It was, of course, Boris Johnson who secured the Tories’ 80-seat majority almost three years ago — before being kicked out of Downing Street in the summer by his own MPs following a string of humiliating scandals. His replacement Truss, elected by just 81,00 Conservative members, lasted less than two months before her colleagues wielded the knife again.

    This carousel of leaders has left some observers pondering how Britain, can repeatedly change its figurehead — not to mention, in Truss’ case, its entire economic direction — without once consulting the public.

    Unsurprisingly, it’s a question opposition leader, Labour’s Keir Starmer, hopes to capitalize on.

    Asking questions to the new PM in the House of Commons Wednesday, Starmer noted that the last time Sunak took part in a vote — his head-to-head contest with Truss — “he got trounced by the former prime minister … who herself got beaten by a lettuce.”

    “Let working people have their say,” Starmer told the PM, “and call a general election.”

    A defiant Sunak replied that his mandate “is based on a manifesto that we were elected on — an election that we won, and they lost.”

    Public panic

    Constitutionally, Sunak is correct.

    The U.K. government retains total control over whether a snap election should be called ahead of the January 2025 deadline for the next vote — unless dozens of Tory MPs suddenly go rogue and decide to bring down their own regime via a no-confidence vote in the Commons.

    And the Tories’ rock-bottom poll ratings mean any kind of electoral gamble is off the table for the foreseeable future. Conservative support among the public — already dire at the tail-end of the Johnson tenure — plunged to record lows under Truss.

    “The short answer to anyone at home or abroad asking why the Conservatives don’t have an election, is because they don’t have to have an election,” said Joe Twyman, director at U.K. polling firm Deltapoll. “Given the situation the polls are in, they would be assured of a loss.”

    Under the British political system, the public votes for a governing party rather than a specific prime minister — and it’s for each party to pick its leader as and when it sees fit. The set-up differs markedly from presidential systems in places like France and the U.S., which are led by directly-elected heads of state.

    “It’s a fundamental rule of a parliamentary democracy that it isn’t the prime minister who wins a mandate at a general election, it’s the parliamentary party,” said Catherine Haddon, a constitutional expert at the Institute for Government think tank. 

    “Once you start going down the route of arguing every prime minister needs to win a general election to be able to hold the job, you are fundamentally changing the system.”

    Furthermore, the U.K.’s “first-past-the-post” voting system tends to deliver single-party rule, meaning coalition governments — which might collapse in times of turbulence, so triggering an election — are historically rare.

    So Sunak retains a healthy parliamentary majority, inherited from Johnson’s 2019 victory.

    Left wanting

    But the one thing counting against the Conservatives is public opinion.

    A YouGov poll this week found 59 percent of the British public think Sunak should call an election — including 38 percent of all Conservative voters — compared with just 29 percent who thought he shouldn’t. That’s far higher than normal, and way above even the peak figure of 41 percent who wanted an election at the height of the Partygate scandal

    “Turmoil in the government, with the Conservatives now two leaders removed from the one who took them to election victory in 2019, has clearly convinced many Britons that the time is right for a new vote,” said YouGov’s head of data journalism, Matthew Smith.

    An internal poll for the opposition Labour Party this week found similar results, with support for an election strongest among swing voters, according to a Labour official. Even a third of those 2019 Conservative voters who are still planning to vote the same way next time round want a snap election, the official said. Those leaning toward Labour are even more enthusiastic about a fresh campaign.

    Other research confirms the public is getting restless. A focus group this week for the non-partisan “More in Common” campaign found seven out of eight participants wanted an election once the current economic crisis has died down — a significant increase on previous exercises.

    Luke Tryl, the U.K. director of More in Common, said most people want “a choice over who is in charge” — although he noted that the same people also often feel conflicted, being “exhausted with the constant politics of the past few years.”

    Consultants at the agency Public First have found similar results in their own focus groups. The firm’s founding partner James Frayne said demands for a general election had “surged in recent weeks, and won’t be going anywhere.” He added: “As far as most voters are concerned, one unelected PM screwed up the economy so badly that another unelected PM must impose brutal austerity in response.”

    Internal dissent

    Indeed, even some Conservatives — chiefly those supportive of Boris Johnson — have suggested an election is necessary following his departure from No. 10 Downing Street.

    Former Cabinet Minister Nadine Dorries said publicly that an election would be “impossible to avoid” after her fellow MPs rejected Johnson’s recent comeback bid. Backbencher Christopher Chope and Tory peer Zac Goldsmith both made similar claims.

    “Imposing a new prime minister no-one voted for goes against the grain of what is democratic,” said one Johnson-supporting Conservative MP. “Colleagues who removed Boris can’t have their cake and eat it. We’ve had a sh*t show since, and appointing Rishi without a single vote is precarious. But colleagues insist they don’t want a general election.”

    For the vast majority of Conservative MPs, who want to avoid a vote at all costs, Sunak appears their best hope of calming the waters and so holding off the clamor for an election.

    “It is legitimate to feel there should be an election,” said a former Johnson adviser. “But in a world where there’s no general election, the best thing for everyone is to have Rishi — because however well he ends up doing, I think he will be quite calm, professional, and not trying to do crazy things that f*ck up all our mortgages.”

    Twyman, from Deltapoll, suggested that ultimately, being accused of dodging democracy is probably the “lesser of two evils” for the Tories.

    “It doesn’t look good for the Conservatives,” he said. “But a Labour majority of 300 doesn’t look good for the Conservatives either.”

    Annabelle Dickson contributed reporting.

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  • Russia defense chief makes unfounded claims of Kyiv ready to use ‘dirty bomb’

    Russia defense chief makes unfounded claims of Kyiv ready to use ‘dirty bomb’

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    Russian Defense Minister Sergei Shoigu on Sunday had telephone calls with his French, British and Turkish counterparts in which he made unfounded claims that Ukraine might be preparing to use a “dirty bomb,” according to Russian readouts of the conversations.

    The conversations took place after Russian President Vladimir Putin recently raised the prospect of using nuclear weapons in the war he launched against Ukraine. And after Shoigu faced intensifying political pressure over a series of disorderly retreats in Ukraine.

    The calls came as Russia continues a mass evacuation of civilians from occupied Kherson in southern Ukraine and defense analysts believe that the movement of people is setting the scene for Moscow to withdraw its troops from a significant part of the region. But among EU diplomats, there are fears that Moscow is only setting the scene for things to get worse.

    During the call with French Defense Minister Sébastien Lecornu, they discussed the situation in Ukraine, “which is rapidly deteriorating,” according to the Russian readout of the call. And Shoigu conveyed “his concerns about possible provocations by Ukraine with the use of a ‘dirty bomb’,” the Russian ministry said without giving any further detail.

    The same content of the readout was provided on the call with Turkish Defense Minister Hulusi Akar.

    The Russian readout of the call with U.K. Defense Minister Ben Wallace talks only about the risk of a “dirty bomb.” However, in none of the readouts does Moscow provide any evidence for its claims.

    The U.K. said that “Shoigu alleged that Ukraine was planning actions facilitated by Western countries, including the U.K., to escalate the conflict in Ukraine,” according to a U.K. statement. “The Defense Secretary refuted these claims and cautioned that such allegations should not be used as a pretext for greater escalation,” it said.

    No statement on the call was immediately made available by the defense ministries of France and Turkey.

    On Friday, Shoigu spoke with U.S. Defense Secretary Lloyd Austin for the first time since May, and, according to a Pentagon readout, in the call “Austin emphasized the importance of maintaining lines of communication amid the ongoing war against Ukraine.”

    Shoigu spoke with Austin again on Sunday, according to the Russian defense ministry. In this case, the Russian readout says only that “they discussed situation in Ukraine.”

    A dirty bomb is a bomb that combines conventional explosives, such as dynamite, with radioactive materials. For Dara Massicot, an analyst at U.S. research company Rand Corporation, “this reads like Russian false flag groundwork.”

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    Jacopo Barigazzi

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  • Moderna Stock Takes Off on Cancer Vaccine News

    Moderna Stock Takes Off on Cancer Vaccine News

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    Moderna


    stock shot up after


    Merck


    said it is exercising an option to work on a personalized cancer vaccine with the Covid-19 vaccine maker.

    Merck (ticker: MRK) will pay


    Moderna


    (MRNA) $250 million for the joint development and future commercialization of the vaccine, which is currently in Phase 2 clinical trials. The two companies had announced a “strategic collaboration” in June 2016.

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  • Science Crossing Borders: Celebrating the Contributions of Immigrant Scientists

    Science Crossing Borders: Celebrating the Contributions of Immigrant Scientists

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    The Vilcek Science Symposium brings immigrant scientists together for a two-day conference at the Gladstone Institutes.

    Press Release


    Oct 5, 2022

    They come from around the world—born in Taiwan, India, Lebanon, Israel, Romania, and Russia, among other places—but they all call the United States home. The scientists presenting at the first Vilcek Science Symposium, taking place Oct. 19-20 at Gladstone Institutes, have something in common other than their top-notch, award-winning research: they’re all immigrants. 

    Organized in partnership with the Gladstone Institutes, the symposium, Science Crossing Borders: Celebrating the Contributions of Foreign-Born Researchers in the United States aims to recognize outstanding science by researchers born outside the U.S. It also provides a platform for the researchers to share their personal stories, network with one another, and raise awareness of the impact of immigration to inclusive and high-quality science. 

    “Even though we come from diverse backgrounds and study very different topics, immigrant scientists share some common experiences,” says Jeanne Paz, Ph.D., conference chair and associate investigator at Gladstone. “We thought it would be nice to meet, create opportunities for collaboration, and brainstorm how we can support trainees who are coming from other countries.”

    “This symposium represents the first time that Vilcek Prizewinners in biomedical science have a specific opportunity to connect in an academic context,” says Jan T. Vilcek, MD, Ph.D., co-founder, CEO, and chairman of the Vilcek Foundation. “We hope that the two-day program will help these leaders learn more about one another’s work and create space for potential collaborations moving forward.”

    A Chance to Connect

    In 2019, Paz won a Vilcek Prize for Creative Promise in Biomedical Science for her research on epilepsy. At the annual Vilcek Awards Gala, she and fellow winner and scientist, the late Angelika Amon, Ph.D., struck up a conversation about some of the unique challenges that immigrant scientists face. They started brainstorming ways to strengthen the community of Vilcek Prizewinners and proposed the idea for a symposium.  

    “When Jeanne Paz and Angelika Amon approached us in 2019 about developing an academic forum for our Vilcek Foundation Prizewinners, we were delighted,” says Vilcek. “It is a testament to Angelika’s lasting impact as a mentor to see this symposium realized, and it speaks deeply to Jeanne’s leadership in supporting the next generation of scientists at the Gladstone Institutes.” 

    “We are thrilled to host this exciting symposium,” says Lennart Mucke, MD, of the Gladstone Institute of Neurological Disease. “An immigrant myself, I deeply appreciate the efforts of the Vilcek Foundation and the pioneering contributions of these outstanding speakers. Their paths beautifully illustrate that science truly is universal and boundless.”

    Inspiring Change

    The scientists presenting at the upcoming symposium work in diverse fields—from physics to biomedicine—and Paz hopes that getting them all in one room will create new collaboration and networking opportunities. But she also hopes that students will tune in for the talks and be inspired by their personal stories. 

    “There’s often this idea in the scientific community that to be successful, you have to come from a very famous lab and follow a particular path, and it’s important for young scientists to see that doesn’t have to be true,” says Paz. “You can come from a very difficult background and move far away from your support network and succeed because you pursued a path that you were passionate about.” Paz herself was born in the Republic of Georgia and moved to the United States for her postgraduate research.

    Many Vilcek Foundation Prizewinners credit not only their backgrounds but the purposeful diversity of their labs with helping them think more expansively about their research subjects. With those messages in mind, the symposium organizers have arranged roundtables, mentoring opportunities, and a panel discussion with a handful of attendees about how being an immigrant has shaped their science. 

    “There is no singular immigrant story or experience, and while our prizes recognize immigrant scientists, each of our prizewinners has a unique experience, focus, and insight that has contributed to their success,” says Rick Kinsel, president of the Vilcek Foundation. “We hope to make this diversity apparent, and to bolster individuals’ understanding of the ways that immigration has a positive impact on our scientific communities, and on society more broadly.”

    Learn more about the symposium: Science Crossing Borders: Celebrating the Contributions of Foreign-Born Researchers in the United States

    The Vilcek Foundation

    The Vilcek Foundation raises awareness of immigrant contributions in the United States and fosters appreciation for the arts and sciences. The foundation was established in 2000 by Jan and Marica Vilcek, immigrants from the former Czechoslovakia. The mission of the foundation was inspired by the couple’s respective careers in biomedical science and art history. Since 2000, the foundation has awarded over $7 million in prizes to foreign-born individuals and has supported organizations with over $5.8 million in grants.

    The Vilcek Foundation is a private operating foundation, a federally tax-exempt nonprofit organization under IRS Section 501(c)(3). To learn more, please visit vilcek.org

    Contact

    Elizabeth Boylan
    Communications Manager
    The Vilcek Foundation 
    www.vilcek.org

    elizabeth.boylan@vilcek.org
    +1 (212) 472-2500

    Source: The Vilcek Foundation

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  • Mouse Embryo Experiment Could Teach Us About Miscarriages

    Mouse Embryo Experiment Could Teach Us About Miscarriages

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    Oct. 3, 2022 — Miscarriages are a devastating, if natural, occurrence. Nearly 1 million pregnant people in the U.S. experience a miscarriage every year, according to the National Advocates for Pregnant Women. New research could lend insight into the causes of some types of early pregnancy loss and maybe one day help prevent miscarriages. 

    In the bioengineering breakthrough, scientists created a mouse embryo in a lab without using sperm or eggs. The experimental embryo, called a model, was grown out of stem cells and developed further than any earlier experiments, with a beating heart and the foundation of a brain within a yolk sac, according to the researchers. 

    The experiment, while conducted with mouse stem cells, could help explain why some human pregnancies fail. Miscarriages occur in up to 15% of pregnancies confirmed by doctors, according to some studies, and also for many pregnant people before they even knew of the pregnancy. This experiment gives researchers a glimpse of a critical developmental stage for the first time. 

    “We are building mouse embryo models, but they have exactly the same principle as real human embryos,” says lead researcher Magdalena Zernicka-Goetz, PhD, professor in mammalian development and stem cell biology at Cambridge University in the U.K. “That’s why they tell us about real pregnancy.”

    With the new mouse models, the researchers can study implantation, the stage when embryos embed themselves in the mother’s body – a stage that’s often difficult for embryos to survive. The same process happens in mouse embryos, which develop very similarly to human embryos at this early stage of life.

    Deciphering the Stem Cell Code 

    Six years ago, researchers from the University of Cambridge and the California Institute of Technology set out to create models that would allow them to study fetal development in three-dimensional form but without the need for human embryos. 

    “We are trying to understand the major principles of time and space that have to be fulfilled” to form a successful pregnancy, Zernicka-Goetz explains. “If those principles are not fulfilled, the pregnancies are terminated, even before women know they’re pregnant.” 

    There are limits on using human embryos for research, and previous experiments have tended to replicate only one aspect of development. That led to two-dimensional experiments: flat cells on the bottom of a petri dish that lack the structural organization of real tissue. 

    The new models are three-dimensional with beating hearts and the yolk sacs in which embryos feed and grow. The models even progressed to forming the beginning of a brain – a research first. 

    The scientists used the foundational cellular “building blocks” called stem cells and managed to get the cells to communicate along a timeline that mimicked natural development, simulating those developmental stages, says Zernicka-Goetz. Those “building blocks” are actually three types of stem cells: pluripotent stem cells that build body tissue, and two other types of stem cells that build the placenta and the amniotic sac. 

    Completing the experiment required the right quantity of each stem cell type. The researchers also needed to understand how those cells exchange information before they can begin to grow. The researchers were able to “decipher the code” of how the cells talk to each other, Zernicka-Goetz says.

    Initially, the three types of stem cells combine, almost like a soup, but when the timing is right, they have to recognize each other and sort themselves. Next, each stem cell type must start building a different structure necessary for fetal development. Zernicka-Goetz thinks of this construction as the architecture of human tissue. 

    With the new technique, researchers can continue investigating the implantation stage and beyond. And they did – tweaking the experiment to create a genetically flawed embryo on purpose.

    Goetz and her team eliminated a certain gene known to regulate how cells establish their own identities. Doing so resulted in the same brain development flaws as in human embryos, providing “a proof of concept” that the experimental models can be used to study other genetic mysteries, she says. 

    Scientists are still in the dark about what some genes do, as well as the point when they become critical to brain development. 

    “Many genes have very early roles in specifying, for example, the position of the head and also how our brain will function,” Zernicka-Goetz says. “We can now use this model system to assess the function of those genes.” 

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  • 8 things to know about the environmental impact of ‘unprecedented’ Nord Stream leaks

    8 things to know about the environmental impact of ‘unprecedented’ Nord Stream leaks

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    The apparent sabotage of both Nord Stream gas pipelines may be one of the worst industrial methane accidents in history, scientists said Wednesday, but it’s not a major climate disaster.

    Methane — a greenhouse gas up to 80 times more powerful than carbon dioxide — is escaping into the atmosphere from three boiling patches on the surface of the Baltic Sea, the largest of which the Danish military said was a kilometer across.

    On Tuesday evening, European Commission President Ursula von der Leyen condemned the “sabotage” and “deliberate disruption of active European energy infrastructure.” 

    Here are eight key questions on the impact of the leaks.

    1. How much methane was in the pipelines?

    No government agency in Europe could say for sure how much gas was in the pipes.

    “I cannot tell you clearly as the pipelines are owned by Nord Stream AG and the gas comes from Gazprom,” said a spokesperson for the German climate and economy ministry. 

    The two Nord Stream 1 pipelines were in operation, although Moscow stopped delivering gas a month ago, and both were hit. “It can be assumed that it’s a large amount” of gas in those lines, the German official said. Only one of the Nord Stream 2 lines was struck. It was not in operation but was filled with 177 million cubic meters of gas last year.

    Estimates of the total gas in the pipelines that are leaking range from 150 million cubic meters to 500 million cubic meters.

    2. How much is being released?

    Kristoffer Böttzauw, the director of the Danish Energy Agency, told reporters on Wednesday that the leaks would equate to about 14 million tons of CO2, about 32 percent of Denmark’s annual emissions.

    Germany’s Federal Environment Agency estimated the leaks will lead to emissions of around 7.5 million tons of CO2 equivalent — about 1 percent of Germany’s annual emissions. The agency also noted there are no “sealing mechanisms” along the pipelines, “so in all likelihood the entire contents of the pipes will escape.”

    Because at least one of the leaks is in Danish waters, Denmark will have to add these emissions to its climate balance sheet, the agency said.

    But it is not clear whether all of the gas in the lines would actually be released into the atmosphere. Methane is also consumed by ocean bacteria as it heads through the water column.

    3. How does that compare to previous leaks?

    The largest leak ever recorded in the U.S. was the 2015 Aliso Canyon leak of roughly 90,000 tons of methane over months. With the upper estimates of what might be released in the Baltic more than twice that, this week’s disaster may be “unprecedented,” said David McCabe, a senior scientist with the Clean Air Task Force.

    Jeffrey Kargel, a senior scientist at the Planetary Research Institute in Tucson, Arizona, said the leak was “really disturbing. It is a real travesty, an environmental crime if it was deliberate.”

    4. Will this have a meaningful effect on global temperatures?

    “The amount of gas lost from the pipeline obviously is large,” Kargel said. But “it is not the climate disaster one might think.”

    Annual global carbon emissions are around 32 billion tons, so this represents a tiny fraction of the pollution driving climate change. It even pales in comparison to the accumulation of thousands of industrial and agricultural sources of methane that are warming the planet. 

    “This is a wee bubble in the ocean compared to the huge amounts of so-called fugitive methane that are emitted every day around the world due to things like fracking, coal mining and oil extraction,” said Dave Reay, executive director of the Edinburgh Climate Change Institute.

    Lauri Myllyvirta, lead analyst at the Centre for Research on Energy and Clean Air, said it was roughly comparable to the amount of methane leaked from across Russia’s oil and gas infrastructure on any given working week. 

    A leak was reported near the Nord Stream 2 pipeline off the coast of Denmark’s Bornholm island | Danish Defence Command

    5. Is the local environment affected?

    While the gas is still leaking, the immediate vicinity is an extremely dangerous place. Air that contains more than 5 percent methane can be flammable, said Rehder, so the risk of an explosion is real. Methane is not a toxic gas, but high concentrations can reduce the amount of available oxygen. 

    Shipping has been restricted from a 5 nautical mile radius around the leaks. This is because the methane in the water can affect buoyancy and rupture a vessel’s hull.

    Marine animals near the escaping gas may be caught up and killed — especially poor swimmers such as jellyfish, said Rehder. But long-term effects on the local environment are not anticipated.

    “It’s an unprecedented case,” he said. “But from our current understanding, I would think that the local effects on marine life in the area is rather small.”

    6. What can be done?

    Some have suggested that the remaining gas should be pumped out, but a German economy and climate ministry spokesperson on Wednesday said this wasn’t possible.

    Once the pipeline has emptied, “it will fill up with water,” the spokesperson added. “At the moment, no one can go underwater — the danger is too great due to the escaping methane.”

    Any repair would be the responsibility of pipeline owner Nord Stream AG, the Germans said.

    7. Should they set it on fire?

    Not only would it look impressive, setting the gas on fire would hugely slash the global warming impact of the leak. Methane is made of carbon and hydrogen, when burned it creates carbon dioxide, which is between 30 and 80 times less planet-warming per ton than methane. Flaring, as it is known, is a common method for reducing the impact of escaping methane.

    From a pure climate perspective, setting the escaping methane on fire makes sense. “Yes, definitely — it will help,” said Piers Forster, director of the Priestley International Centre for Climate at the University of Leeds. 

    But there would be safety issues and potential environmental concerns, including air pollution from the combustion. “With land — in particular the inhabited and touristic island of Bornholm — nearby, you would not venture into this,” said Rehder.

    No government has yet indicated that this is under consideration.

    8. How long will it last and what next?

    “We expect that gas will flow out of the pipes until the end of the week. After that, first of all, from the Danish side, we will try to get out and investigate what the cause is, and approach the pipes, so that we can have it investigated properly. We can do that when the gas leak has stopped,” Danish Energy Agency director Böttzauw told local media.

    This article is part of POLITICO Pro

    The one-stop-shop solution for policy professionals fusing the depth of POLITICO journalism with the power of technology


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  • The Top 10 Most Visited Capitals Published by Visited

    The Top 10 Most Visited Capitals Published by Visited

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    Visited, the travel app, has published the top 10 most visited capital cities as per their international traveling users.

    Press Release


    Jun 28, 2022

    Arriving In High Heels publishes Top 10 most visited capitals as per Travel App’s Visited international users. Visited is a travel app that helps keep travel memories alive as well as inspire future travel. With the app, users can access travel lists that align with their travel goals and get personalized stats. The new list feature, features popular places to visit such as Ancient Sites, as well as travel list for adventures such as places to go diving and for those that travel for the food even culinary experiences. New lists are being added on a monthly basis and lists are constantly being updated to ensure that any changes in travel destinations are reflected in the top 10 list.

    The top 10 most visited capital cities as per the app’s users are all found in Europe: 

    1. Paris, France – Is the most visited capital in the world. Paris has endless sights to visit, which is no surprise why it is the most visited capital in the world.
    2. London, England – The city is probably best viewed from the London Eye observation wheel.
    3. Rome, Italy – Visitors come from all over the world to see the many ruins and excavations including the famous Colosseum.
    4. Amsterdam, Netherlands – Amsterdam is a city best visited by taking the water canals or cycling through its multiple bike paths.
    5. Prague, Czech Republic – Is home to the famous Charles Bridge which was build in the medieval ages and crosses the Vltava river. 
    6. Berlin, Germany – Berlin has a vast history and multiple palaces and has become known in the art scene.
    7. Vatican City, Vatican – Is home to the biggest church in the world the St. Peter’s Basilica, the same church which is home to the pope.
    8. Vienna, Austria – Vienna is known for its museums, there are over 60 of them! It is also the capital of music. 
    9. Brussels, Belgium – Brussels is famous for its Moules-frites, beer and chocolate which makes a visit to this capital extra sweet.
    10. Budapest, Hungary – With the famous parliament building and Chain bridge, visitors can also bath in what is known as a capital of thermal baths.

    For more stats and interactive list travelers can download Visited on iOS or Android

    To learn more about the Visited app and its latest feature update, please visit https://visitedapp.com

    About Arriving In High Heels Corporation

    Arriving In High Heels Corporation is a mobile app company; Visited is their most popular app. For inspiration on travel destinations, travel stats and the latest travel news, follow Visited on FacebookTwitterInstagram, and Pinterest. Other apps include Pay Off Debt and X-Walk

    Contact Information

    Anna Kayfitz
    anna@arrivinginhighheels.com

    Source: Arriving In High Heels Corporation

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  • Rick Sharp Alzheimer’s Foundation Announces 3rd Annual ‘Alzheimer’s Day 2020’

    Rick Sharp Alzheimer’s Foundation Announces 3rd Annual ‘Alzheimer’s Day 2020’

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    This year’s event will feature renowned scientists and an opening meditation with special guest Deepak Chopra, M.D.

    Press Release



    updated: Nov 11, 2020

    The Rick Sharp Alzheimer’s Foundation, named in memory of the late CEO of Circuit City and founder of CarMax, has announced its 3rd annual “Alzheimer’s Day 2020.” While previous events have been held at the University of Richmond and the Science Museum of Virginia, this year’s event will be held virtually. Complimentary registration in advance is required – www.ricksharpalz.org. Previous speakers have included famed researcher Dr. Rudy Tanzi and New York Times best-selling author of “Still Alice” Lisa Genova.

    Panelists will include Dr. John Lazo of the University of Virginia, Dr. Constantine Lykestsos of Johns Hopkins, and Dr. Robert Innis from the National Institute of Mental Health. The evening will include special guest Deepak Chopra. The panel will be moderated by Dr. Catherine Franssen. The panel discussion will include the status of current research, the impact of COVID-19, and brain health.

    Sherry Sharp, founder of the Rick Sharp Alzheimer’s Foundation, said, “Since our inaugural event, we’ve met thousands of people and raised hundreds of thousands of dollars to achieve our goal of curing Alzheimer’s Disease. Together, with your support, we have donated over $2 million and every penny raised goes directly to research.”

    Sherry also serves on the Board of Directors of Cure Alzheimer’s Fund (www.curealz.org).

    For more information about the event and sponsorship opportunities, contact Director of Donor Engagement Carli Nelson at 833.CURE ALZ, Option 1, and/or visit www.ricksharpalz.org.

    About Dr. John Lazo: Dr. Lazo is a professor of Pharmacology and Chemistry at the University of Virginia School of Medicine.

    About Dr. Constantine Lyketsos: Dr. Lyketsos is the Chair of Psychiatry at Johns Hopkins Bayview Medical Center.

    About Dr. Robert Innis: Dr. Innis is Chief of the Molecular Imaging Brand at the National Institute of Mental Health. 

    About Deepak Chopra, M.D.: Chopra is an expert in the field of mind-body healing and a world-renowned speaker and author on the subject of alternative medicine.

    About Dr. Catherine L. Franssen: Dr. Franssen is currently the Scientist in Residence at the Science Museum of Virginia. She is an Associate Professor in the Department of Psychology at Longwood University.

    About the Rick Sharp Alzheimer’s Foundation: Rick Sharp was a business leader, husband, father, and friend to many. For over a decade, he served as the CEO of electronics retailer Circuit City. He went on to found car superstore CarMax, was a founding investor and Chairman of the Board of footwear brand Crocs, and electronics company Flextronics. Shortly after his death at age 67 from Alzheimer’s in 2014, Sherry founded the Rick Sharp Alzheimer’s Foundation. The non-profit focuses on supporting world-class research and increasing ALZ awareness. 100% of all money raised goes to finding a cure.

    Media Inquiries  
    Cara Dickens 
    Rocket Pop Media 
    cara@rocketpopmedia.com 

    Event Inquiries
    Carli Nelson
    Rick Sharp Alzheimer’s Foundation
    carli@ricksharpalz.org

    Source: Rick Sharp Alzheimer’s Foundation

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  • Dallas Researcher Edward T. Rincón Pens New Book Highlighting Need to Include More Multicultural Audiences in Research, Outreach

    Dallas Researcher Edward T. Rincón Pens New Book Highlighting Need to Include More Multicultural Audiences in Research, Outreach

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    Press Release



    updated: Sep 9, 2020

    ​​​​​​As the nation navigates its way through the COVID-19 pandemic, social justice protests, and the 2020 Census, Edward T. Rincón, Ph.D., a veteran Dallas researcher, is urging companies, government agencies, nonprofits, and academics to adapt their research practices to improve the quality of data collected for multicultural participants.

    The U.S. population has experienced a dramatic demographic transformation with the increased presence of multicultural persons – including Blacks, Hispanics, and Asians – challenging a research industry that has failed to keep pace with their linguistic and cultural nuances.

    This growing disconnect between the research industry and the U.S. multicultural population is a key factor in the declining survey response rates and misleading conclusions related to programs and policies that impact the quality of life for multicultural populations. Industry practices that reinforce this trend include:

    • Minimal support in languages other than English;
    • The use of small sample sizes that prohibit reliable analyses; aggregation of ethnically distinct groups that obscure key ethnic differences;
    • Overlooking the needs of persons with visual, hearing, and reading impairments; and,
    • A lack of knowledge of multicultural communities can be traced to the failure of academic institutions to prepare their graduates.

    Rincón, president of Rincón & Associates, identifies methodological problems in high-stakes studies that include multicultural persons and offers practical solutions in his newly released book “The Culture of Research, Insights from a 45-year practice in the design and execution of multicultural research” (Writer’s Marq LLC, 2020). Dr. Rincón has taught research methods at several North Texas universities and worked with hundreds of corporate, government, and social organizations.

    “With an estimated multicultural population of 121 million in the U.S., it’s more important than ever that anyone doing research takes the time to do it right – that means making sure the research is well-designed and includes as many diverse voices as possible,” Rincón said. “Research practitioners have to expand their knowledge and practices beyond the traditional models that they learned in college research courses.”

    Unlike other research methods books, Rincón draws off his vast experience using a forensic analytics approach to detect and document the methodological errors that are often made in surveys and other measurement systems that include multicultural populations. The book has useful charts, graphics, data, and case studies that illustrate practices that produce misleading results.

    Pepper Miller, nationally recognized African-American market researcher, author, and speaker, said, “[Ed] offers dozens of practical examples from his 40+ years of experience in multicultural research and reliable resources that will undoubtedly help readers conduct relevant market research studies with the ‘New America’ while delivering effective outcomes for brands and organizations.”

    Rincon explained, “One of the major goals of this book is to raise the standards in multicultural research. My interest is in discussing specific problems and challenges in multicultural research that traditional textbooks and classes are likely to overlook.”  

    CONTACT:
    Neil Foote
    Foote Communications
    neil@neilfoote.com
    214-448-3765

    Source: Edward T. Rincón, Ph.D.

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  • Uplifting Athletes Non-Profit to Host Third Annual Young Investigator Draft Presented by CSL Behring on Saturday, March 7, 2020 at Lincoln Financial Field in Philadelphia

    Uplifting Athletes Non-Profit to Host Third Annual Young Investigator Draft Presented by CSL Behring on Saturday, March 7, 2020 at Lincoln Financial Field in Philadelphia

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    An Event Celebrating the Next Generation of All-Star Researchers Who Are Working on Breakthrough Treatments and Cures for Rare Diseases

    Press Release



    updated: Feb 27, 2020

    ​​​​​​Uplifting Athletes, a Philadelphia-based nonprofit organization that inspires the Rare Disease Community with hope through the power of sport, announced plans today for the third annual Young Investigator Draft, presented by CSL Behring, taking place on Saturday, March 7, 2020 at Lincoln Financial Field, home of the Philadelphia Eagles of the National Football League (NFL).

    The football theme of the Young Investigator Draft is inspired by the NFL Draft. Instead of drafting emerging young football talent, this unique draft turns the spotlight on the next generation of promising young medical researchers who are “drafted” and awarded research grants by Uplifting Athletes in order to help them pursue new treatments and potential cures for many of the world’s rarest diseases.

    “The Young Investigator Draft serves as a powerful celebration of research within the field of rare diseases, providing a platform to distribute research funding to up-and-coming young researchers and honoring our ‘Rare Disease Champion Team’,” says Rob Long, Executive Director of Uplifting Athletes. “We’re proud to have already awarded $180,000 in grants over the past two years alone and look forward to continued success. With every new year, we discover brilliant young researchers who help us learn more about these underserved diseases.”

    “CSL Behring is proud to continue sponsoring this innovative program that supports emerging science and rare disease research,” added Kevin Kovaleski, Vice President, Global Commercial Development, Transplant, CSL Behring. “The Young Investigator Draft reinforces our promise to patients by empowering researchers to focus on the rare disease community.”

    Uplifting Athletes and its annual Young Investigator Draft focus on rare diseases because they are often underserved and so diverse. Rare diseases are so prevalent that 1 in 10 Americans are affected by rare diseases. That’s a higher percentage than cancer and AIDS combined. Additionally, they transcend gender, race, age, sexual orientation and socioeconomic status. Unfortunately, due to the large variety and complexity of rare diseases, there is very little support for rare disease research, especially compared to funding for more common diseases such as heart disease and diabetes. Uplifting Athletes exists to close this significant funding gap. 

    Uplifting Athletes emphasis for the 2020 Young Investigator Draft is on building greater audience participation for the draft event on Saturday, March 7, 2020, as well as inviting more medical research-related corporate sponsorship and involvement in the event. By doing so, Uplifting Athletes believes it can help transform the way society views, engages with and supports the research that will benefit many future generations. If you are not able to attend the event in person, please tune into the live stream on our Facebook page at bit.ly/2020YID at 7 p.m. EST.

    ABOUT UPLIFTING ATHLETES

    Founded in 2007, Uplifting Athletes fulfills its mission to inspire the Rare Disease Community with hope through the power of sport with a powerful network of over 20 college football student-athlete led chapters, Uplifting Ambassadors and Team UA participants.

    Since its inception, Uplifting Athletes has raised more than $5 million to support the mission of Uplifting Athletes and its charitable programs: Rare Disease Awareness, Rare Disease Research, Uplifting Experiences and Uplifting Leaders. To learn more, please visit upliftingathletes.org

    Uplifting Athletes Media Contact:

    Rob Long
    Office: +717-737-7900 ex 701
    Email: rob.long@upliftingathletes.org

    Source: Uplifting Athletes

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  • Landmark Study Seeks Participants With VCFS-Related Psychosis to Help Create Biobank of Human Neural Tissue to Develop Innovative Treatments

    Landmark Study Seeks Participants With VCFS-Related Psychosis to Help Create Biobank of Human Neural Tissue to Develop Innovative Treatments

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    The Virtual Center for Velo-Cardio-Facial Syndrome collaborates with the Center for Precision Neuropsychiatry based in the Department of Psychiatry at Columbia University Vagelos College of Physicians and Surgeons

    Press Release



    updated: Oct 23, 2019

    A landmark study is calling for at least 50 people in the U.S. with Velo-Cardio-Facial Syndrome (VCFS)-related psychosis to provide blood samples to create the world’s largest VCFS biobank to date of tiny spheres of neural tissue called “cerebral organoids.” Given that current medications used to treat VCFS-related psychosis are largely ineffective, researchers hope to discover novel and effective treatments for this condition by studying these cerebral organoids.

    The Center for Precision Neuropsychiatry, founded by Sander Markx, M.D., and based in the Department of Psychiatry at Columbia University Vagelos College of Physicians and Surgeons, is collaborating in this research with the Virtual Center for Velo-Cardio-Facial Syndrome, founded by Robert J. Shprintzen, Ph.D. VCFS was first described in 1978 by Dr. Shprintzen and he was the first to report that psychosis is a common clinical feature of the syndrome.

    VCFS, also known as DiGeorge syndrome, Shprintzen syndrome, and 22q11.2 Deletion Syndrome, is caused by a deletion of DNA from one copy of a specific region of chromosome 22 containing more than two dozen genes. It is the most common genetic multiple congenital anomaly syndrome and the most common genetic cause of psychosis. About one-third of people with VCFS develop psychosis and 1-2% of all patients with schizophrenia have a 22q11.2 microdeletion.

    The researchers hope to learn more about how psychosis develops, how better treatments might be identified for this condition, and why people with VCFS develop mental illness at such a high rate. Ultimately, their intent is to develop effective treatments for people at high genetic risk for developing psychiatric illness.

    A total of 50 participants with VCFS who are genetically confirmed to have a 22q11.2 deletion and are diagnosed with a psychotic disorder will be asked to provide a small blood sample for this study. In addition, the researchers will ask an unaffected first-degree family member of the donor (either same-sex sibling or same-sex parent) to contribute a blood sample to serve as a control subject. Phlebotomists will visit the participants to draw the blood in the comfort of their homes or location of their choice.

    While some of the study participants will come from a pool of cases currently registered at the Virtual Center, more may be needed: the study is open to interested parties diagnosed with VCFS who live in the 48 U.S. contiguous states. VCFS patients who meet the requirements and want to participate in the study can register at www.vcfsmentalillness.org or email info@vcfscenter.org for further information.

    Sander Markx, M.D., Assistant Professor of Psychiatry at Columbia University Vagelos College of Physicians and Surgeons and Principal Investigator, has a long-standing interest in VCFS. “We need to reach a better understanding of what goes on in the developing brain that ultimately gives rise to the increased risk for psychosis in patients with this genetic condition,” he states. “Improved understanding will help us develop novel, more efficacious medications that target specific disease mechanisms so we can achieve better clinical outcomes with fewer side effects for our patients. We hope that our process will guide future treatment for mental and cognitive disorders and ultimately reveal basic biology of debilitating disorders, such as schizophrenia and autism.”

    As Robert J. Shprintzen, Ph.D., President and Chairman of the Board at the Virtual Center for VCFS, observes, “This study is of significant importance for sufferers of VCFS all over the world. Although VCFS is the most common genetic cause of psychosis and the genetic mutation that causes VCFS has been known for more than 25 years, so far, treatments for these problems have largely been ineffective. We expect that our collaborative research with eminent colleagues at one of the most highly regarded psychiatric facilities in the world will translate to more effective patient care.”

    Additional information about the blood draw

    The blood sample from the subject and his/her relative will be used to develop iPSCs and organoids to better understand VCFS biology and responses to medications. For each case, it will be determined whether he/she suffers from a psychotic condition. Following this initial study, the team plans to run clinical trials of medications that show promise in the organoid response.

    The study will use induced pluripotent stem cells (iPSCs) obtained from donor blood. White blood cells are reprogrammed to become stem cells and those stem cells are grown into cerebral organoids, which will be exposed to drug libraries to determine how the brain tissue responds. This type of research, called translational research, yields results that could ultimately help lead to the identification and development of new treatments for this debilitating condition.

    About The Virtual Center for Velo-Cardio-Facial Syndrome, Inc.

    The Virtual Center for Velo-Cardio-Facial Syndrome, Inc. is an open-access 501(c)3, internet-based charitable organization that provides personalized information to people whose lives have been touched by VCFS and who are seeking applicable research and clinical expertise regarding the management of the syndrome. There is no charge for this service, which is funded by voluntary donations.

    About Velo-Cardio-Facial Syndrome

    Velo-Cardio-Facial syndrome (VCFS) is the most common genetic multiple congenital anomaly disorder in humans. It is caused by a microdeletion of DNA from chromosome 22, typically encompassing approximately 40 genes. It is known by a number of other names, including DiGeorge syndrome, conotruncal anomalies face syndrome, Sedlačková syndrome and, more recently, 22q11.2 Deletion Syndrome. Approximately 200 distinct congenital anomalies and disorders are associated with VCFS. Recent data has shown that more than 1 in every 1,000 pregnancies have the deletion from chromosome 22 that causes VCFS. Because so many problems can occur in people with VCFS, it is difficult to have all of the specialists with special knowledge of the syndrome needed for required diagnosis and management together in one location. The Virtual Center allows experts to spread knowledge and information pertinent to individual cases anywhere in the world, thereby sharing expertise and educating local practitioners at the same time.

    Press Contacts:

    The Virtual Center for Velo-Cardio-Facial Syndrome, Inc.

    Robert J. Shprintzen, Ph.D.
    E-mail: info@vcfscenter.com
    Tel: 315-559-4685
    Web: www.vcfsmentalillness.org

    Fortress Strategic Communications for The Virtual Center for Velo-Cardio-Facial Syndrome, Inc.

    Evan Bloom, CEO
    Tel: 315-744-4912
    E-mail: evan@fortresscomms.com
    Web: www.fortresscomms.com

    Source: The Virtual Center for Velo-Cardio-Facial Syndrome, Inc.

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  • Launch of Migraine Cannabis Study Planned With Patient Support Group MigraineBuds, Chronic Pain Specialist Dr. Sana-Ara Ahmed and the Canadian Institute for Medical Advancement

    Launch of Migraine Cannabis Study Planned With Patient Support Group MigraineBuds, Chronic Pain Specialist Dr. Sana-Ara Ahmed and the Canadian Institute for Medical Advancement

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    Patient support group takes matters into their own hands, and seeks out help to conduct a Migraine Cannabis Study

    Press Release



    updated: Nov 10, 2017

    MigraineBuds is an organization started by a patient advocate Jodie Epstein who suffers from chronic migraines. This online support group has information on cannabis specific to migraines and headaches. The MigraineBuds community is 1750 patients strong and growing, which provides a forum for discussing everything cannabis- and migraine-related. Jodie was eager to create a safe, non-judgmental space to have these conversations.

    Migraine affects approximately 10 percent of people worldwide, with many patients unable to find adequate pain management. Many migraineurs also suffer from Medication Overuse Headache (MOH). MOH occurs when pain relief medications are taken too frequently. This can occur when a patient has taken too much caffeine, ergots, or pharmaceutical medications such as opioids, triptans or non-steroidal anti-inflammatory drugs.

    “The social reform of chronic pain medicine includes medical cannabis as a viable and first choice option for migraine sufferers. Review of medical history indicates that the Cannabis sativa plant was frequently used by physicians to treat acute and chronic migraine headaches in North America and was discontinued when drug prohibition removed the plant from the pharmacopeia. I have been treating chronic migraine sufferers with medical cannabis with great results and look forward to the research benefits for all of society.”

    – Dr. Sana-Ara Ahmed, M.D., FRCPC Anesthesiologist & Chronic Pain Specialist

    What we are looking to study and why

    The MigraineBuds community is interested and keen to participate in clinical research that will help to demonstrate the efficacy of cannabis in the treatment of migraine. The proposed study will also examine the effect cannabis may have on MOH.

    The Canadian Institute for Medical Advancement, a research organization, has agreed to help conduct the study. Accordingly, Dr. Sana-Ara Ahmed, a clinical Anesthesiologist & Chronic Pain Specialist, has agreed to participate in the research study. Dr. Ahmed is an advocate for chronic migraine pain patients and treats numerous patients at her clinic The Health Boutique™. Dr. Ahmed is a specialist and educator in the use of medical cannabis for chronic pain, including migraines, and advocates the use of cannabis as an effective method of treatment.

    “There is a shift in research looking at a patient-centric approach and one in which patients are partners and collaborators in research whose participation is core to the success of any research study. It’s a privilege to be asked to help Jodie and her group with this study,” says Sabrina Ramkellawan, Founder of the Canadian Institute for Medical Advancement.

    To increase the chances of success with this study, a call for Sponsors, Licensed Producers, and Physicians who understand how life-changing this evidence could be for migraine sufferers is being sent out. Study launch is planned for early 2018, and the hope is to have a number of collaborators in this important study.

    Additionally, the organization is also looking for interested potential participants. If you suffer from migraines with MOH, and would like to be a part of migraine history, please connect with Jodie Epstein! jodie@migrainebuds.com https://www.facebook.com/groups/migrainebuds

    For media inquiries and/or research partnerships contact Sabrina Ramkellawan at 416-543-5041 or sabrina@cifma.ca. Website: www.cifma.ca

    Source: Canadian Institute for Medical Advancement

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  • Enago and Thieme Partner to Empower Researchers to Achieve Publication Goals

    Enago and Thieme Partner to Empower Researchers to Achieve Publication Goals

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    This collaboration will facilitate access to high-quality editing services for researchers.

    Press Release



    updated: Jul 31, 2017

    ​Enago, an internationally trusted name in author services for the global research community has recently concluded an agreement with Thieme, the award-winning international medical and science publisher serving both health professionals and students for more than 125 years. This collaboration will benefit researchers hoping to improve their chances of being accepted in world class journals by assisting them in enhancing the overall quality of their submissions.

    Thieme is a reputed publisher known for its high-quality standards in journal content and presentation in all of its publications. With the same focus on quality, Enago emerges as the perfect partner for Thieme to drive impactful, error-free research in the field of medicine and science. Authors can perfect and polish their journal manuscripts by using Enago’s high-quality English editing services through an exclusive online portal.

    Thieme is committed to fostering high-quality, ground-breaking research in the fields of medicine and science. Through this partnership with Enago, we aim to support authors in sharing their research and opinion in order to advance science and discovery. We are delighted to work with Enago to offer quality author support services for maximizing the overall impact of their submissions.

    Daniel Schiff, Senior Vice President, Thieme

    Enago’s medicine and science editors are Ph.D./MD-qualified published authors and experienced reviewers, who are competent to offer quality pre-submission manuscript reviews. With expertise in nearly 200 different medical and scientific disciplines, Enago’s editors understand the intricacies involved in making a manuscript ready for submission. A rich working experience of 15–20 years in the field of science and medicine equips Enago’s editors to ensure that every edited manuscript will meet internationally accepted quality standards.

    “Thieme is committed to fostering high-quality, ground-breaking research in the fields of medicine and science. Through this partnership with Enago, we aim to support authors in sharing their research and opinion in order to advance science and discovery. We are delighted to work with Enago to offer quality author support services for maximizing the overall impact of their submissions,” said Daniel Schiff, Senior Vice President, Thieme.

    Commenting on the collaboration, Rajiv Shirke, VP Global Operations, Enago, said, “We are proud to be associated with Thieme to play an integral part in enhancing the overall quality of research submissions in the field of medicine and science. Over the years, Enago has established itself as a trusted partner for delivering exceptional quality author support services to researchers worldwide. This partnership is an opportunity for us to leverage our expertise and assist authors in refining their submissions to Thieme.”

    For further information, visit the website www.enago.com/thieme.

    About Enago

    Enago is the trusted name in author services for the global research community. Since 2005, we have worked with researchers in more than 125 countries improving the communication of their research and helping them to achieve success in publication. Enago is a preferred partner for leading publishers, societies, as well as universities worldwide. We have offices in Tokyo, Seoul, Beijing, Shanghai, Istanbul, and New York. Enago operates globally with regional teams supporting researchers locally.

    To learn more about Enago, please visit www.enago.com.

    About Thieme

    Thieme Publishing Group is a medical and scientific publishing house employing more than 1,000 staff and maintaining offices in ten cities, including New York, Delhi, Rio and Stuttgart, Germany. Founded in 1886, the Thieme name has become synonymous with high quality and excellence in online and print publishing. Thieme publishes 150 peer-reviewed journals and more than 350 new books annually. The company has a rapidly growing array of web-based products in medicine and science. State-of-the-art online products Thieme MedOne, Thieme E-Journals, the Thieme Electronic Book Library, the medical student website WinkingSkull.com, and Thieme MyCourse, an innovative web-based platform for faculty to customize their own course materials.

    For more information about Thieme, please visit www.thieme.com.

    Source: Enago

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  • Policy Press Publisher Partners With Enago to Offer Manuscript Preparation Services

    Policy Press Publisher Partners With Enago to Offer Manuscript Preparation Services

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    Enago’s author services support researchers to enhance the quality of their submissions to
    Policy Press

    Press Release



    updated: Jun 2, 2017

    Policy Press announced today their partnership with Enago, a leading author service provider that specifically caters to the large section of the global research community for whom English is a second language (ESL).

    Policy Press was founded in 1996 as an academic publisher based in the Faculty of Social Sciences and Law at the University of Bristol, UK. It specializes in the social sciences and aims to improve social conditions with publications that make a positive difference to learning and research, policy, and practice. It publishes a variety of products, including textbooks, academic journals, and monographs. 

    “This partnership with Enago allows us to offer the option of language editing services to researchers around the world. Enago’s service should help to improve the quality of author manuscripts submitted to the press from authors for whom English is not their first language.”

    Julia Mortimer, Sales and Marketing Director, Policy Press

    Enago is a trusted name in author services for the global research community. Since 2005, Enago has worked with more than 100,000 researchers in 125 different countries, improving the communication of their research and helping them to achieve success in international publication. Enago is the preferred partner for leading academic publishers, societies and universities worldwide. Enago has offices in Tokyo, Seoul, Beijing, Shanghai, Istanbul and New York, and operates globally with regional teams supporting researchers locally.

    “This partnership with Enago allows us to offer the option of language editing services to researchers around the world. Enago’s service should help to improve the quality of author manuscripts submitted to the press from authors for whom English is not their first language,” commented Julia Mortimer, Sales and Marketing Director, Policy Press.

    “Enago is delighted to be collaborating with Policy Press and the newly launched Bristol University Press to help serve the needs of the global scholarly community by providing easy access to high-quality manuscript preparation services.  We are delighted to be able to support Policy Press authors with their article submissions,” said Rajiv Shirke, Vice President, Global Operations, Enago.

    For further information, visit the website: enago.com/policypress

    About Enago

    Enago is the trusted name in author services for the global research community. Since 2005, we have worked with researchers in more than 125 countries, improving the communication of their research and helping them to achieve success in publication. Enago is a preferred partner for leading publishers, societies, as well as universities worldwide. We have offices in Tokyo, Seoul, Beijing, Shanghai, Istanbul, and New York. Enago operates globally with regional teams supporting researchers locally.

    To learn more about Enago, please visit: enago.com

    About Policy Press

    Policy Press is a non-profit university press committed to influencing social change through international research and scholarship. Policy Press is a global ambassador for the University of Bristol, and through our work we support the University’s intellectual and social missions. We publish over 120 peer-reviewed books each year and 7 journals in a wide range of print and digital editions for researchers, students, professionals, practitioners, politicians, policy makers and the informed general reader, as well as for libraries and other institutions globally.

    To learn more about Policy Press, please visit: policypress.co.uk

    Source: Enago

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  • The Science Platform Capeia Introduces a Novel Scoring Algorithm for Monitoring the Impact of Articles

    The Science Platform Capeia Introduces a Novel Scoring Algorithm for Monitoring the Impact of Articles

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    Press Release



    updated: May 25, 2017

    The newly launched science platform Capeia not only seeks to stimulate discussion but is also committed to spreading the information and ideas that are expressed on this website into the depths of the World Wide Web. So much so that it provides an extra crowdfunding scheme to collect funds with which to provide a reward on a monthly basis for the scientist whose contribution attracts the most attention.

    For accurately determining an article’s attention, Capeia has conceived an algorithm that not only covers conventional parameters such as views and shares but also measures whether an article is read entirely or dropped halfway through. Furthermore, significant weight is put onto whether visitors’ comments or inquiries are addressed by the author in due time. Capeia, therefore, does not define impact merely through the response an article draws by the community but explicitly observes the attention it gets by its author following publication.

    Rüdiger Schweigreiter, Editor: “Capeia does not support a ‘Fire and Forget’ publishing policy. Impact is not a one-way street. We do not limit the definition of impact to the attention an article receives from the audience but extend it to the post-publication attention it gets from its author. Taking into account both the audience and the author for metric analysis lives up to Capeia’s mission to strengthening the relationship between scientists and the interested public.”

    Capeia is proud to put this scoring algorithm into use with an article on exoplanets by SETI scientist Franck Marchis. In this essay, Dr. Marchis expounds the state of the art of exoplanet detection and outlines future technological possibilities. A simulation, which is shown here for the first time, illustrates what exoplanets might look like when viewed through the next generation of telescopes that are currently under construction.

    Media Contact: Rüdiger Schweigreiter, PhD; rschwei@capeia.com; +43-650-6441971

    Source: Capeia

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