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Tag: public-health officials

  • Will We Get Omicron’d Again?

    Will We Get Omicron’d Again?

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    In COVID terms, the middle of last autumn looked a lot like this one. After a rough summer, SARS-CoV-2 infections were down; hospitalizations and deaths were in a relative trough. Kids and workers were back in schools and offices, and another round of COVID shots was rolling out. Things weren’t great … but they weren’t the most terrible they’d ever been. There were vaccines; there were tests; there were drugs. The worst winter development the virus might produce, some experts thought, might involve the spawning of some nasty Delta offshoot.

    Then, one year ago this week, Omicron appeared. The first documented infection with the variant was identified from a specimen collected in South Africa on November 9, 2021; by December 1, public-health officials had detected cases in countries all around the globe, including the United States. Twenty days later, Omicron had unseated Delta as America’s dominant SARS-CoV-2 morph. The new, highly mutated variant could infect just about anyone it encountered—even if they’d already caught a previous version of the virus or gotten several shots of a vaccine. At the beginning of December, and nearly two years into the pandemic, researchers estimated that roughly one-third of Americans had contracted SARS-CoV-2. By the middle of February this year, that proportion had nearly doubled.

    Omicron’s arrival and rapid spread around the world was, and remains, this crisis’s largest inflection point to date. The variant upended scientists’ expectations about SARS-CoV-2’s evolution; it turned having COVID into a horrific norm. Now, as the U.S. approaches its Omicronniversary, conditions may seem ripe for an encore. Some experts worry that the emergence of another Greek-letter variant is overdue. “I’m at a loss as to why we haven’t seen Pi yet,” says Salim Abdool Karim, an epidemiologist at the Centre for the AIDS Programme of Research in South Africa. “I think there’s a chance we still will.”

    A repeat of last winter seems pretty unlikely, experts told me. But with a virus this unpredictable, there’s no guarantee that we won’t see disaster unspool again.

    A lot has changed since last year. For one thing, population immunity to SARS-CoV-2 is higher. Far more people have received additional doses of vaccine, many of them quite recently, with an updated formula that’s better tailored to the variants du jour. Plus, at this point, nearly every American has been infected at least once—and most of them with at least some subvariant of Omicron, says Shaun Truelove, an epidemiologist and a modeler at Johns Hopkins University. These multiple layers of protection make it more challenging for the average SARS-CoV-2 spin-off to severely sicken people. They also raise transmission obstacles for the coronavirus in whatever form it takes.

    Omicron does seem to have ushered in “a different phase of the pandemic,” says Verity Hill, an evolutionary virologist at Yale. The variants that took over different parts of the world in 2021 rose in a rapid succession of monarchies: Alpha, Beta, Gamma, Delta. But in the U.S. and elsewhere, 2022 has so far been an oligarchy of Omicron offshoots. Perhaps the members of the Omicron lineage are already so good at moving among hosts that the virus hasn’t needed a major upgrade since.

    If that’s the case, SARS-CoV-2 may end up a victim of its own success. The Omicron subvariants BQ.1 and BQ1.1 appear capable of spreading up to twice as fast as BA.5, according to laboratory data. But their takeover in the U.S. has been slow and halting, perhaps because they’re slogging through a morass of immunity to the Omicron family. That alone makes it less likely that any single Omicron subvariant will re-create the sudden surge of late 2021 anytime soon. In South Africa and the United Kingdom, for instance, different iterations of Omicron seem to have triggered just modest bumps in sickness in recent months. (That said, those countries—with their distinct demographics and vaccination and infection histories—aren’t a perfect bellwether for the U.S.)

    For an Omicron 2021 redux to happen, SARS-CoV-2 might need to undergo a substantial genetic makeover—which Abdool Karim thinks would be very difficult for the virus to manage. In theory, there are only so many ways that SARS-CoV-2 can scramble its appearance while retaining its ability to latch onto our cells; by now, its options should be somewhat slimmed. And the longer the Omicron line of succession persists, the tougher it may be to upend. “It’s just getting harder to compete,” Hill told me.

    But the world has gotten overconfident before. Even if SARS-CoV-2 doesn’t produce a brand-new version of itself, low uptake of the bivalent vaccine could allow our defenses to wither, driving a surge all the same, Truelove told me. Our transmission-dampening behaviors too are slacker than they’ve been since the pandemic’s start. This time last year, 50 to 60 percent of Americans were regularly wearing masks. The latest figures, many of them several months old, are closer to 30 percent. “The more opportunities you give the virus to get into somebody,” Hill said, “the more chances you give it to get the group of mutations that could help it take off.” Immunocompromised people who remain chronically infected with older variants, such as Alpha or Delta, could also become the sites of new viral offshoots. (That may be how the world got Omicron to begin with.)

    Going on probability alone, “it seems more likely that we’ll keep going with these subvariants of Omicron rather than dealing with something wholly brand-new,” says Maia Majumder, an epidemiologist at Boston Children’s Hospital. But Lauren Ancel Meyers, an infectious-disease modeler at the University of Texas at Austin, warns that plenty of uncertainty remains. “What we don’t have is a really data-driven model right now that tells us if, when, where, and what kind of variants will be emerging in the coming months and years,” she told me. Our window into the future is only getting foggier too as fewer people submit their test results—or take any test at all—and surveillance systems continue to go offline.

    It wouldn’t take another Omicron-type event to hurl us into disarray. Maybe none of the Omicron subvariants currently jockeying for control will surge ahead of the pack. But several of them might yet drive regional epidemics, Majumder told me, depending on the local nitty-gritty of who’s susceptible to what. And as winter looms, some of the biggest holes in our COVID shield remain unpatched. People who are immunocompromised are losing their last monoclonal-antibody treatments, and although powerful drugs exist to slash the risk of severe disease and death, useful preventives and treatments for long COVID remain sparse.

    Our nation’s capacity to handle new COVID cases is also low, Majumder said. Already, hospitals around the country are being inundated with other respiratory viruses—RSV, flu, rhinovirus, enterovirus—all while COVID is still kicking in the background. “If flu has taken over hospital beds,” says Srini Venkatramanan, an infectious-disease modeler at the University of Virginia, even a low-key wave will “feel like it’s having a much bigger impact.”

    As the country approaches its second holiday season with Omicron on deck, this version of the virus may “feel familiar,” Majumder pointed out. “I think people perceive the current circumstances to be safer than they were last year,” she said—and certainly, some of them are. But the fact that Omicron has lingered is not entirely a comfort. It is also, in its way, a reminder of how bad things once were, and how bad they could still get.

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    Katherine J. Wu

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  • What Comes After the Search Warrant?

    What Comes After the Search Warrant?

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    If Donald Trump committed crimes on his way out of the White House, he should be subject to the same treatment as any other alleged criminal. The reason for this is simple: Ours is a government of laws, not of men, as John Adams once observed. Nobody, not even a president, is above those laws.

    So why did I feel nauseous yesterday, watching coverage of the FBI executing a search warrant at Trump’s Mar-a-Lago estate?

    Because this country is tracking toward a scale of political violence not seen since the Civil War. It’s evident to anyone who spends significant time dwelling in the physical or virtual spaces of the American right. Go to a gun show. Visit a right-wing church. Check out a Trump rally. No matter the venue, the doomsday prophesying is ubiquitous—and scary. Whenever and wherever I’ve heard hypothetical scenarios of imminent conflict articulated, the premise rests on an egregious abuse of power, typically Democrats weaponizing agencies of the state to target their political opponents. I’ve always walked away from these experiences thinking to myself: If America is a powder keg, then one overreach by the government, real or perceived, could light the fuse.

    Think I’m being hysterical? I’ve been accused of that before. But we’ve seen what happens when millions of Americans abandon their faith in the nation’s core institutions. We’ve seen what happens when millions of Americans become convinced that their leaders are illegitimate. We’ve seen what happens when millions of Americans are manipulated into believing that Trump is suffering righteously for their sake; that an attack on him is an attack on them, on their character, on their identity, on their sense of sovereignty. And I fear we’re going to see it again.

    It’s tempting to think of January 6, 2021, as but one day in our nation’s history. It’s comforting to view the events of that day—the president inciting a violent mob to storm the U.S. Capitol and attempt to overturn the results of a free and fair election—as the result of unprecedented conditions that happened to converge all at once, conditions that are not our national norm.

    But perhaps we should view January 6 as the beginning of a new chapter.

    It’s worth remembering that Trump, who has long claimed to be a victim of political persecution, threatened to jail his opponent, Hillary Clinton, throughout the 2016 campaign, reveling in chants of “Lock her up!” at rallies nationwide. (Republicans did not cry foul when the FBI announced an investigation into Clinton just days before the election.) It was during that campaign—as I traveled the country talking with Republican voters, hoping to understand the Trump phenomenon—that I began hearing casual talk of civil war. Those conversations were utterly jarring. People spoke matter-of-factly about amassing arms. Many were preparing for a day when, in their view, violence would become unavoidable.

    I remember talking with Lee Stauffacher, a 65-year-old Navy veteran, outside an October Trump rally in Arizona. “I’ve watched this country deteriorate from the law-and-order America I loved into a country where certain people are above the law,” Stauffacher said. “Hillary Clinton is above the law. Illegal immigrants are above the law. Judges have stopped enforcing the laws they don’t agree with.”

    Stauffacher went on about his fondness of firearms and his loathing of the Democratic Party. “They want to turn this into some communist country,” he said. “I say, over my dead body.”

    This sort of rhetoric cooled, for a time, after Trump’s victory. But then came Special Counsel Robert Mueller’s investigation into Russian election interference and possible collusion. And the subsequent arrests of some of the president’s closest confidants. Then came the first impeachment of Trump himself. By the time his reelection campaign got under way, Trump was fashioning himself a wartime president, portraying himself on the front lines of a pitched battle between decent, patriotic Americans and a “deep state” of government thugs who aim to enforce conformity and silence dissent.

    On December 18, 2019, the day he was impeached for the first time, Trump tweeted a black-and-white photo that showed him pointing into the camera. “THEY’RE NOT AFTER ME … THEY’RE AFTER YOU,” read the caption. “I’M JUST IN THE WAY.”

    As I hit the road again in 2020, crisscrossing the nation to get a read on the Republican base, it was apparent that something had changed. There was plenty of that same bombast, all the usual chesty talk of people taking matters into their own hands. But whereas once the rhetoric had felt scattered—rooted in grievances against the left, or opposition to specific laws, or just general discomfort with a country they no longer recognized—the new threats seemed narrow and targeted. Voter after voter told me there had been a plot to sabotage Trump’s presidency from the start, and now there was a secretive plot to stop him from winning a second term. Everyone in government—public-health officials, low-level bureaucrats, local election administrators—was in on it. The goal wasn’t to steal the election from Trump; it was to steal the election from them.

    “They’ve been trying to cheat us from the beginning,” Deborah Fuqua-Frey told me outside a Ford plant in Michigan that Trump was visiting during the early days of the pandemic. “First it was Mueller, then it was Russia. Isn’t it kind of convenient that as soon as impeachment failed, we’ve suddenly got this virus?”

    I asked her to elaborate.

    “The deep state,” she said. “This was domestic political terrorism from the Democratic Party.”

    This kind of thinking explains why countless individuals would go on to donate their hard-earned money—more than $250 million in total—to an “Election Defense Fund” that didn’t exist. It explains why others swarmed vote-counting centers, intimidated poll workers, signed on to shoddy legal efforts, flocked to fringe voices advocating solutions such as martyrdom and secession from the union, threatened to kill elections officials, boarded buses to Washington, and ultimately stormed the United States Capitol.

    What made January 6 so predictable—the willingness of Republican leaders to prey on the insecurities and outright paranoia of these voters—is what makes August 8 so dangerous.

    “The Obama FBI began spying on President Trump as a candidate,” Senator Marsha Blackburn of Tennessee tweeted this morning. “If they can do this to Trump, they will do it to you!”

    “If they can do it to a former President, imagine what they can do to you,” read a tweet from Republicans on the House Judiciary Committee. They followed up: “The IRS is coming for you. The DOJ is coming for you. The FBI is coming for you. No one is safe from political punishment in Joe Biden’s America.”

    “If there was any doubt remaining, we are now living in a post constitutional America where the Justice Department has been weaponized against political threats to the regime, as it would in a banana republic,” the Texas Republican Party tweeted. “It won’t stop with Trump. You are next.”

    It won’t stop with Trump—that much is certain. The House Republican leader, Kevin McCarthy, all but promised retaliation against the Justice Department should his party retake the majority this fall. Investigations of President Joe Biden and his son Hunter were already more or less guaranteed; the question now becomes how wide of a net congressional Republicans, in their eagerness to exact vengeance on behalf of Trump and appease a fuming base, cast in probing other people close to the president and his administration.

    Assuming that Trump runs in 2024, the stakes are even higher. If Biden—or another Democrat—defeats him, Republicans will have all the more reason to reject the results, given what they see as the Democrats’ politically motivated investigation of the likely Republican nominee. If Trump wins, he and his hard-line loyalists will set about purging the DOJ, the intelligence community, and other vital government departments of careerists deemed insufficiently loyal. There will be no political cost to him for doing so; a Trump victory will be read as a mandate to prosecute his opponents. Indeed, that seems to be exactly where we’re headed.

    “Biden is playing with fire by using a document dispute to get the @TheJusticeDept to persecute a likely future election opponent,” Senator Marco Rubio of Florida tweeted. “Because one day what goes around is going to come around.”

    And then what? It feels lowest-common-denominator lazy, in such uncertain times, to default to speculation of 1860s-style secession and civil war. But it’s clearly on the minds of Americans. Last year, a poll from the University of Virginia showed that a majority of Trump voters (52 percent) and a strong minority of Biden voters (41 percent) strongly or somewhat agreed that America is so fractured, they would favor red and blue states seceding from the union to form their own countries. Meanwhile, a poll from The Washington Post and the University of Maryland showed that one in three Americans believes violence against the government is justified, and a separate poll by NPR earlier this year showed that one in 10 Americans believes violence is justified “right now.”

    It’s hard to see how any of this gets better. But it’s easy to see how it gets much, much worse.

    We don’t know exactly what the FBI was looking for at Mar-a-Lago. We don’t know what was found. What we must acknowledge—even those of us who believe Trump has committed crimes, in some cases brazenly so, and deserves full prosecution under the law—is that bringing him to justice could have some awful consequences.

    Is that justice worth the associated risks? Yesterday, the nation’s top law-enforcement officers decided it was. We can only hope they were correct.

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    Tim Alberta

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