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Tag: pharmacology

  • 180 Life Sciences Announces an Agreement for a Clinical Pharmacology Study Testing a New Formulation of CBD for Enhanced Oral Uptake – World News Repo… – Medical Marijuana Program Connection

    180 Life Sciences Announces an Agreement for a Clinical Pharmacology Study Testing a New Formulation of CBD for Enhanced Oral Uptake – World News Repo… – Medical Marijuana Program Connection

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    /EIN News/ — PALO ALTO, Calif., Aug. 07, 2023 (GLOBE NEWSWIRE) — 180 Life Sciences Corp. (NASDAQ: ATNF) (“180 Life Sciences” or the “Company”), today announced that an agreement has been reached with Prof. Avi Domb of the Hebrew University, School of Pharmacy, and with Prof. Elyad Davidson, of Hadassah Hospital, to perform a clinical pharmacology (“Pharmacokinetic” or “PK”) study of the uptake of cannabidiol (CBD) in a formulation which can be delivered as a pill orally. The PK study will seek to determine how much CBD is taken up into the blood of volunteers.

    While CBD preparations have previously been approved by the U.S. Food and Drug Administration (FDA) for rare forms of childhood epilepsy, a major problem in working with CBD is its low and unpredictable and variable uptake following the most convenient delivery form, by mouth, as CBD in oil. This has hampered progress and clinical trials seeking potential uses for CBD, such as for the treatment of pain, post-traumatic stress disorder (PTSD), head trauma, and more, where reports have suggested the possibility of benefits. To help try to solve this problem, Prof. Domb and colleagues have developed “ProNanoLipospheres” (PNL), a mixture of components available over-the-counter, which form little droplets and have been shown to be absorbed from the gastrointestinal tract into blood. The dosage form has been shown in preliminary testing in rats to…

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  • Village of Oregon mother arrested for child neglect after 4-year-old ODs on marijuana gummies – Medical Marijuana Program Connection

    Village of Oregon mother arrested for child neglect after 4-year-old ODs on marijuana gummies – Medical Marijuana Program Connection

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    Village of Oregon police arrested the mother of a 4-year-old Wednesday after the child was taken to the emergency room the day before because the child had overdosed on marijuana gummies.

    Police said they were called to Stoughton Hospital just before 5 p.m. Tuesday because the child’s mother and another adult were having difficulty getting the child to respond.

    Police later determined that the overdose had occurred at a home in Oregon. In a search of the home at about 12:30 p.m. Wednesday, they found drug paraphernalia and arrested the child’s mother on a tentative child neglect charge. Police did not release the mother’s name.

    The child was treated at the hospital and released.

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  • Supermom In Training: The things I need as a I get older

    Supermom In Training: The things I need as a I get older

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    I was never a “brand” person. When it came to household items, beauty products, etc. I preferred trying something new than having any sort of loyalty to a specific brandname. But now that I’ve had time to weed through many various products, I find there are things I need as I get older.

    I need a good all-purpose cleaner I love. It needs to work hard (so I don’t have to) and I need it to smell good. That’s why I ADORE anything from Mrs. Meyers. They are hardworking household cleaners, hand soap, and body care products that are made with cruelty-free formulas containing essential oils and natural ingredients. Not only are they effective but they smell absolutely incredible!

    I need a good facial cleanser. Now that I’m in my 40s, I find my skin to be trickier than ever, with dry spots as well as oil spots. A good cleaner for morning and night is a must, and I really like the the Cleansing Balm from Motter. It’s a 3-in-1 transformative cleansing balm that is formulated with 80% antioxidant-rich botanical butter and oils. It deeply nourishes skin and easily removes make-up when warmed into a cleansing oil, emulsifying into a hydrating cleansing milk when in contact with water. It’s never drying and it doesn’t strip your skin of its moisture. 

    I need a good moisturizer for my face. Enter The Ordinary’s Natural Moisturizing Factors + PhytoCeramides. It’s the second of six new formulations to launch under The O. Lab. This is a richer moisturizer than most in that it can be used by those with dry or dehydrated skin, or those looking for additional barrier support, which I need after months of cold, dry weather.

    I need a good face serum. That includes the face serums from BKIND. They have different formulas depending on your needs, whether you want to soothe, illuminate, or refine your skin (I love the brightening face serum with dragon fruit extract and squalane). Their nail polish is also incredible and very durable – I hand-wash all my dishes, garden, craft, and play hard with my hands, and my nails look great for up to two whole weeks.

    I need comfy indoor footwear. Because I work from home and have mostly hardwood floors, I’m always looking for a great, comfortable indoor shoe or pair of slippers. The Cushion Homey Snuggles from Reef live up to their name: it’s the perfect combo of slipper and shoe. They have a cushiony footbed lined with cozy faux shearling that keep tootsies warm and comfy, and an easy on/off upper made of toasty, 100% recycled wool felt. They offer support and ultimate wear all day long.

    A full-time work-from-home mom, Jennifer Cox (our “Supermom in Training”) loves dabbling in healthy cooking, craft projects, family outings, and more, sharing with readers everything she knows about being an (almost) superhero mommy.

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  • Supermom In Training: The things I need as I get older

    Supermom In Training: The things I need as I get older

    [ad_1]

    I was never a “brand” person. When it came to household items, beauty products, etc. I preferred trying something new than having any sort of loyalty to a specific brandname. But now that I’ve had time to weed through many various products, I find there are things I need as I get older.

    I need a good all-purpose cleaner I love. It needs to work hard (so I don’t have to) and I need it to smell good. That’s why I ADORE anything from Mrs. Meyers. They are hardworking household cleaners, hand soap, and body care products that are made with cruelty-free formulas containing essential oils and natural ingredients. Not only are they effective but they smell absolutely incredible!

    I need a good facial cleanser. Now that I’m in my 40s, I find my skin to be trickier than ever, with dry spots as well as oil spots. A good cleaner for morning and night is a must, and I really like the the Cleansing Balm from Motter. It’s a 3-in-1 transformative cleansing balm that is formulated with 80% antioxidant-rich botanical butter and oils. It deeply nourishes skin and easily removes make-up when warmed into a cleansing oil, emulsifying into a hydrating cleansing milk when in contact with water. It’s never drying and it doesn’t strip your skin of its moisture. 

    I need a good moisturizer for my face. Enter The Ordinary’s Natural Moisturizing Factors + PhytoCeramides. It’s the second of six new formulations to launch under The O. Lab. This is a richer moisturizer than most in that it can be used by those with dry or dehydrated skin, or those looking for additional barrier support, which I need after months of cold, dry weather.

    I need a good face serum. That includes the face serums from BKIND. They have different formulas depending on your needs, whether you want to soothe, illuminate, or refine your skin (I love the brightening face serum with dragon fruit extract and squalane). Their nail polish is also incredible and very durable – I hand-wash all my dishes, garden, craft, and play hard with my hands, and my nails look great for up to two whole weeks.

    I need comfy indoor footwear. Because I work from home and have mostly hardwood floors, I’m always looking for a great, comfortable indoor shoe or pair of slippers. The Cushion Homey Snuggles from Reef live up to their name: it’s the perfect combo of slipper and shoe. They have a cushiony footbed lined with cozy faux shearling that keep tootsies warm and comfy, and an easy on/off upper made of toasty, 100% recycled wool felt. They offer support and ultimate wear all day long.

    A full-time work-from-home mom, Jennifer Cox (our “Supermom in Training”) loves dabbling in healthy cooking, craft projects, family outings, and more, sharing with readers everything she knows about being an (almost) superhero mommy.

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  • Poteau PD Chief shares concerns if SQ 820 passes; special election to approve recreational marijuana slated Tuesday | News – Medical Marijuana Program Connection

    Poteau PD Chief shares concerns if SQ 820 passes; special election to approve recreational marijuana slated Tuesday | News – Medical Marijuana Program Connection

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    Poteau Police Chief Billy Hooper shared with the Poteau Kiwanis Club during the local civic organization’s weekly meeting Feb. 23 at Western Sizzlin his concerns about State Question 820 regarding approving recreational marijuana, which is up for vote in Tuesday’s special election.

    “As you all have seen, we’ve had legal marijuana here for about four years now,” Hooper said. “We’re still trying to get ahead of that. When they passed that, they left it wide open. They didn’t really know what they were going to do with it. They set up an Oklahoma marijuana authority group to police it. They didn’t have any agents. They really didn’t know how to handle it, so it kind of went wide open.”

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  • The Complicated Landscape of Seniors and Medications

    The Complicated Landscape of Seniors and Medications

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    Oct. 10, 2022 – When the time came for Ginny Erickson-Ebben’s elderly mother to move into a senior living facility in 2018, the entire family agreed the best place was near Erickson-Ebben. The weather was warm where she lived in Texas, and Erickson-Ebben lived just a mile down the road from the facility. She also had the time to help with her mother’s care. While happily and willingly taking on those duties, she didn’t realize what a big job she’d signed up for. 

    Ebben did have physical help from a caretaker at the facility, but she was not authorized to manage medications – Erickson-Ebben’s mother took 20. Even for a bright, middle-aged woman like Erickson-Ebben, the medication management was a complicated task. 

    “I was ignorant of how overwhelming the job would be,” Erickson-Ebben admits. “There was a nurse at the senior living facility who stopped in once a day to check on my mother, but otherwise the job fell to me, and it was stressful.”

    Erickson-Ebben developed a system to keep everything straight. She made regular trips to the pharmacy to pick up the medications, and then, once a week, carefully counted out the meds and placed them in her mother’s pillboxes, separated by morning, afternoon, and evening doses. “It was scary at first, because I didn’t know what pill did what, but after a month, I learned them all and knew what I was doing,” she says. “But I was always worrying about what would happen if she missed a pill or if she took the wrong one at the wrong time.”

    Like many seniors, Erickson-Ebben’s mother had a host of ailments and illnesses, and managing the prescriptions to keep them all in check is a huge undertaking. Recently, the American Medical Association took steps to help with the problem, issuing a new policy called “Reducing Polypharmacy as a Significant Contributor to Senior Morbidity.” 

    Reducing Polypharmacy 

    The doctor who championed the new policy is Louisville, KY-based Tom James III, MD. He’s been concerned for some time about the complicated picture of patients – especially seniors – taking multiple medications. 

    “There’s an inverse relationship between the number of prescriptions a patient takes and their longevity,” he explains. “Of course, patients who are sicker are on more medications, but while all drugs are tested for their side effects, they’re not tested in combination.”

    As a result, says James, every patient taking multiple medications becomes their own individual test site. Compounding the issue, he says, is the fact that in medical school, doctors receive training for adding medications, but not subtracting them. 

    Another compounding issue is the fact that, like Erickson-Ebben’s mother, many senior patients have multiple doctors treating them at once. Today’s modern medicine means that, often, doctors don’t really have opportunities to discuss their mutual patients in person. 

    “It used to be that we’d chat in the doctor’s lounge, often comparing notes on a patient,” says James. “Now we often put information into electronic charts, but don’t talk face-to-face.”

    What’s sometimes lost, says James, is a chance for multiple doctors to be on the same page about a patient’s medications. “Medication profiles often don’t catch all the drug interactions,” says James, “because the tools we use are not discriminatory.”

    This spills over into over-the-counter meds and supplements, too, which can sometimes interact with prescription drugs. All in all, many elderly patients are at risk for the complications of over-medication.

    Erickson-Ebben found it essential that she and her family research the medications her mother was taking, and why. “You have to advocate for the patient,” she says. “Unfortunately, if there’s a reaction to a medication, you need to research that, too.”

    In the case of Erickson-Ebben’s mother and her 20 medications, if one caused a rash, it was difficult to know which. “You can’t just take them off one medication,” she points out. “Talk to the doctors about your concerns, and don’t let them be dismissive of patients just because they’re elderly.”

    Creating a Safety Net 

    The new AMA policy aims to create a network of caretakers to educate patients about the significant effects of all medications, as well as many supplements. It encourages pharmacists, doctors, and other caretakers to teach patients to bring lists of all updated medications/supplements to each point of care. 

    The idea is to “get patients thinking in terms of becoming the victim of too many medications,” James says. “Ask questions when you need answers.”

    Many doctors have limited time with patients these days, so advocacy is crucial. “If there’s an adult child or home-health nurse in the picture, they should review the medication list at least twice a year with the patient’s primary care physician,” says James. “Too often, if a doctor didn’t write a prescription on the list, he or she won’t mess with it. So we hope a pharmacist might catch the potential interaction.”

    Erickson-Ebben’s family specifically chose to work with one hospital system, hoping there would be good coordination between doctors. But that didn’t happen. “The doctors didn’t always communicate well with each other,” says Erickson-Ebben. ”We found that each specialist was focused on their specialty only.” 

    This is part of the current gap in care, one that James hopes to begin resolving with the new AMA policy. In the end, he says, the current system relies too much on the “I hope this will work,” approach. “We need to go beyond the resolution and add in an educational approach, too.”

    The new AMA policy is a good first step on the road to improving health care for seniors, and James hopes to keep moving the needle. “There’s universal agreement that there’s a problem,” he says. “There’s not yet a universal agreement on the approach.”

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