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Tag: meta-analysis

  • Hypnosis Could Work Wonders on IBS

    Hypnosis Could Work Wonders on IBS

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    The change in Zack Rogers was sudden. In the middle of his 12th birthday party, his stomach started hurting. He went to bed early that night, missing much of his own slumber party, and then stayed home from school the whole next week. The stomach pain was excruciating, and he couldn’t keep any food down. He lost 40 pounds in just a few weeks.

    Zack spent the next three years in and out of hospitals and trying medicines that didn’t seem to work. His doctors eventually told the family that they had only one option: surgery to remove large parts of his damaged colon. But Zack’s mom, Angela Rogers, wasn’t on board. She had lost faith in his medical team and feared such an invasive step, so she asked another gastroenterologist for a second opinion. The new doctor suggested that Zack try one last treatment before surgery: hypnotherapy, in which a clinical professional helps a patient become deeply focused and relaxed in order to change their patterns of thinking.

    This time, the change was gradual, but no less dramatic. In the evening after his first hypnotherapy session, Zack felt nauseated but kept his dinner down. Over the next few weeks, he stopped throwing up in school and regained the stamina to play basketball and go for bike rides. Today, Zack is a freshman in college, living away from home—something he wouldn’t have thought was possible before he was hypnotized. “If I never did hypnosis,” he told me, “I would be a complete mess. I genuinely don’t know where I would be.”

    As far-fetched as it may seem, science supports the idea that digestive disorders can be treated with psychological interventions, including hypnosis. Research dating back to the 1980s suggests that, at least in the short term, hypnotherapy can be an effective treatment for irritable bowel syndrome, a gut disorder characterized by painful gastrointestinal symptoms but no visible damage to the gut. Now scientists are investigating whether it might also bring relief to patients with inflammatory bowel disease, who, like Zack, have observable damage to their digestive tract.

    Although hypnosis is a powerful relaxation tool on its own, in clinical settings, it’s most often combined with other, better-studied psychotherapy techniques, such as cognitive behavioral therapy. Research suggests that CBT, which is commonly used to treat conditions such as depression and anxiety, can also be helpful in the treatment of gastrointestinal disorders.

    Unlike CBT, hypnosis retains a reputation for quackery, and is regularly portrayed in pop culture and stage shows as a tool for exercising control over participants—willing or otherwise. And some practitioners do use it for debunked treatments, including recovered memory therapy. But whether hypnotherapy is legitimized as a medical tool has real stakes. Hypnosis practitioners believe—and there’s some research to back this up—that the technique may amplify the effectiveness of more well-established psychological interventions and therefore has the potential to provide rare benefit to patients

    Hypnosis has a long history as a pain reliever. In the first half of the 19th century, before anesthetics were widely available, some surgeons hypnotized their patients. Even today, hypnosis proponents claim that it may be an effective alternative treatment for chronic back pain and the stress of childbirth; a growing body of research suggests that hypnosis can be a cost-effective and side-effect free analgesic for some people with chronic pain, though good clinical data are hard to come by.

    The first randomized controlled trial of hypnotherapy for IBS was published in 1984. Among the participants—a small group of mostly female patients with severe, treatment-resistant disease— those who received hypnotherapy showed greater improvements in abdominal pain, bloating, and bowel function than those who received psychotherapy plus a placebo medication. A 2014 meta-analysis found that about half of IBS patients who try hypnotherapy see at least short-term improvements in their symptoms.

    The evidence for hypnotherapy isn’t as robust in the treatment of IBD, which is really an umbrella term for ulcerative colitis (Zack’s diagnosis) and Crohn’s disease. But there’s reason to believe that hypnosis could yield similar success in addressing symptoms of those conditions. The line between IBD and IBS can be murky; more than a quarter of IBD patients in remission have IBS as well. And although the evidence is still mixed—a study published in 2021, for example, found no difference in treatment outcomes between standard medical treatments and hypnotherapy—some early evidence suggests that hypnotherapy can also reduce inflammation in patients with ulcerative colitis. One small study found that just one session of hypnotherapy reduced ulcerative-colitis patients’ blood levels of several inflammatory markers.

    Perhaps most important, a large body of research shows a strong link between cognition and digestion. Millions of neurons, collectively known as the enteric nervous system, regulate our digestion and are in constant communication with the central nervous system. This connection, called the “brain-gut axis,” may be why we feel so many emotions in our gut, whether the butterflies of anxiety or the clench of anger. It might also explain why both anxiety and depression are more common among patients with IBD compared with the general population. “Unequivocally, stress plays a major role in any digestive disease,” Gary Lichtenstein, a gastroenterology professor and the director of the Inflammatory Bowel Disease Center at the Hospital of the University of Pennsylvania, told me.

    When this brain-gut axis gets out of whack, it’s known to worsen some digestive disorders. In patients with gastrointestinal issues, the tissues in the gut can become hypersensitive over time. The brain learns to interpret signals from the gut, including normal functioning, as discomfort. This faulty communication results in what experts now call disorders of gut-brain interaction (DGBIs), which include IBS, functional dyspepsia, and other digestive disorders (but not IBD). Hypnosis, proponents say, can help patients rewire the cognitive-digestive connection. In many IBS and IBD cases, “we know there’s a mind-gut connection that can only be helped by a mental-health expert,” says Mark Mattar, a gastroenterologist and director of the IBD center at MedStar Georgetown University Hospital.

    Mattar works closely with Ali Navidi, the clinical psychologist to whom Zack was referred in 2020. Navidi told me that at his practice, GI Psychology, 83 percent of patients with DGBIs who complete at least 10 hypnotherapy sessions achieve their treatment goals, which usually amount to reducing pain, bloating, and other uncomfortable symptoms enough to go about their day-to-day life. His data are unpublished but in line with other studies on IBS showing that more than 80 percent of patients who get gut-directed hypnotherapy as part of their treatment plan experience improvements in pain and other GI symptoms. Those numbers are even higher among children and adolescents.

    Such findings persuaded the American College of Gastroenterology to recommend gut-directed psychotherapies—including hypnosis and CBT—for the treatment of IBS symptoms in its 2021 guidelines. Still, even among IBS patients, they’re not commonly used. No one appears to have studied the popularity of hypnosis specifically among IBS patients, but a 2017 study found that only 15 percent of people diagnosed with IBS had ever pursued “psychological therapies” of any kind.

    For many patients who follow through with hypnotherapy, the experience is not what they expect. Patients may conflate clinical hypnosis with entertainment hypnosis, where subjects quack like a duck or forget their own name. But at practices like Navidi’s, the therapist instead focuses on helping the patient enter a trance state—the same type of consciousness we all experience when we lose track of time working, scrolling Instagram, or driving and suddenly arriving at our destination. “When we’re in a trance, we have this intense, focused concentration, and that can be used in powerful ways,” Navidi said.

    Once the patient is in a trance state, therapists use guided imagery and suggestion to target specific gastrointestinal symptoms. “People get into a very relaxed state, and in that state I start to make suggestions about how the brain and the gut can work together better,” Jessica Gerson, a psychologist at NYU Langone’s Inflammatory Bowel Disease Center, told me. Gerson instructs her IBD patients to imagine the lining of their intestines healing. During his trance states, Zack was able to envision a control room for his pain in which he could dial knobs up and down. “I could turn the stomach pain down to a one or a zero, and it would go away,” Zack recalled recently, a note of surprise still in his voice.

    Many patients initially fear that during hypnosis they are ceding control of their mind and body to the hypnotherapist, Gerson told me. But patients are always “totally conscious, totally in control.” Indeed, Navidi and Gerson use this trance state to show patients exactly how much control they have over their own body. “Having a sense of agency is therapeutic,” Gerson said.

    These days, many gastroenterologists see psychotherapies like hypnosis as an important part of a holistic treatment plan—even for IBD. (IBD patients who do respond to hypnotherapy are likely to continue to need medical monitoring and interventions, Lichtenstein said.) While gut-directed hypnotherapy still hasn’t been proved to help IBD patients without co-occurring IBS symptoms, there’s not much of a downside to trying. The experts I spoke with agreed that hypnosis is relatively risk-free as long as it is administered by a clinician, patients continue to be monitored by their medical doctors, and therapists screen potential patients for severe mental illness and untreated trauma. Patients, too, need to consider whether they can afford hypnotherapy. Like many mental-health services, it’s not always covered by insurance. Zack’s sessions were $265 each out of pocket, but according to Angela, “it was worth every cent and then some.”

    Zack remembers getting stressed out a lot as a kid—over grades, making friends, basketball games, or nothing in particular. He credits Navidi with alleviating not only his stomach pain but also the relentless anxiety; he still uses the relaxation techniques he learned from Navidi when he gets worried about school or a basketball game.

    Zack is still on medication for his ulcerative colitis; every eight weeks he has an injection of Stelara, a medication that works by blocking inflammatory proteins. But after two years of appointments with Navidi, for the first time since his 12th birthday, his symptoms are reliably under control—and stress doesn’t make them come roaring back. He hasn’t had a flare up in about a year and a half. Most days, he doesn’t think about his diagnosis at all.

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    Kate Wheeling

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  • Whatever Happened to Carpal Tunnel Syndrome?

    Whatever Happened to Carpal Tunnel Syndrome?

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    Diana Henriques was first stricken in late 1996. A business reporter for The New York Times, she was in the midst of a punishing effort to bring a reporting project to fruition. Then one morning she awoke to find herself incapable of pinching her contact lens between her thumb and forefinger.

    Henriques’s hands were soon cursed with numbness, frailty, and a gnawing ache she found similar to menstrual cramps. These maladies destroyed her ability to type—the lifeblood of her profession—without experiencing debilitating pain.

    “It was terrifying,” she recalls.

    Henriques would join the legions of Americans considered to have a repetitive strain injury (RSI), which from the late 1980s through the 1990s seized the popular imagination as the plague of the modern American workplace. Characterized at the time as a source of sudden, widespread suffering and disability, the RSI crisis reportedly began in slaughterhouses, auto plants, and other venues for repetitive manual labor, before spreading to work environments where people hammered keyboards and clicked computer mice. Pain in the shoulders, neck, arms, and hands, office drones would learn, was the collateral damage of the desktop-computer revolution. As Representative Tom Lantos of California put it at a congressional hearing in 1989, these were symptoms of what could be “the industrial disease of the information age.”

    By 1993, the Bureau of Labor Statistics was reporting that the number of RSI cases had increased more than tenfold over the previous decade. Henriques believed her workplace injury might have had a more specific diagnosis, though: carpal tunnel syndrome. Characterized by pain, tingling, and numbness that results from nerve compression at the wrist, this was just one of many conditions (including tendonitis and tennis elbow) that were included in the government’s tally, but it came to stand in for the larger threat. Everyone who worked in front of a monitor was suddenly at risk, it seemed, of coming down with carpal tunnel. “There was this ghost of a destroyed career wandering through the newsroom,” Henriques told me. “You never knew whose shoulder was going to feel the dead hand next.”

    But the epidemic waned in the years that followed. The number of workplace-related RSIs recorded per year had already started on a long decline, and in the early 2000s, news reports on the modern plague all but disappeared. Two decades later, professionals are ensconced more deeply in the trappings of the information age than they’ve ever been before, and post-COVID, computer use has spread from offices to living rooms and kitchens. Yet if this work is causing widespread injury, the evidence remains obscure. The whole carpal tunnel crisis, and the millions it affected, now reads like a strange and temporary problem of the ancient past.

    So what happened? Was the plague defeated by an ergonomic revolution, with white-collar workers’ bodies saved by thinner, light-touch keyboards, adjustable-height desks and monitors, and Aeron chairs? Or could it be that the office-dweller spike in RSIs was never quite as bad as it seemed, and that the hype around the numbers might have even served to make a modest problem worse, by spreading fear and faulty diagnoses?

    Or maybe there’s another, more disturbing possibility. What if the scourge of RSIs receded, but only for a time? Could these injuries have resurged in the age of home-office work, at a time when their prevalence might be concealed in part by indifference and neglect? If that’s the case—if a real and pervasive epidemic that once dominated headlines never really went away—then the central story of this crisis has less to do with occupational health than with how we come to understand it. It’s a story of how statistics and reality twist around and change each other’s shape. At times they even separate.

    The workplace epidemic was visible only after specific actions by government agencies, employers, and others set the stage for its illumination. This happened first in settings far removed from office life. In response to labor groups’ complaints, the Occupational Safety and Health Administration began to look for evidence of RSIs within the strike-prone meatpacking industry—and found that they were rampant.

    Surveillance efforts spread from there, and so did the known scope of the problem. By 1988, OSHA had proposed multimillion-dollar fines against large auto manufacturers and meatpacking plants for underreporting employees’ RSIs; other businesses, perhaps spooked by the enforcement, started documenting such injuries more assiduously. Newspaper reporters (and their unions) took up the story, too, noting that similar maladies could now be produced by endless hours spent typing at the by-then ubiquitous computer keyboard. In that way, what had started playing out in government enforcement actions and statistics morphed into a full-blown news event. The white-collar carpal tunnel crisis had arrived.

    In the late 1980s, David Rempel, an expert in occupational medicine and ergonomics at UC San Francisco, conducted an investigation on behalf of California’s OSHA in the newsroom of The Fresno Bee. Its union had complained that more than a quarter of the paper’s staff was afflicted with RSIs, and Rempel was there to find out what was wrong.

    The problem, he discovered, was that employees had been given new, poorly designed computer workstations, and were suddenly compelled to spend a lot of time in front of them. In the citation that he wrote up for the state, Rempel ordered the Bee to install adjustable office furniture and provide workers with hourly breaks from their consoles.

    A computer workstation at The Fresno Bee in 1989 (Courtesy of David Rempel)

    Similar injury clusters were occurring at many other publications, too, and reporters cranked out stories on the chronic pain within their ranks. More than 200 editorial employees of the Los Angeles Times sought medical help for RSIs over a four-year stretch, according to a 1989 article in that newspaper. In 1990, The New York Times published a major RSI story—“Hazards at the Keyboard: A Special Report”—on its front page; in 1992, Time magazine ran a major story claiming that professionals were being “Crippled by Computers.”

    But ergonomics researchers like Rempel would later form some doubts about the nature of this epidemic. Research showed that people whose work involves repetitive and forceful hand exertions for long periods are more prone to developing carpal tunnel syndrome, Rempel told me—but that association is not as strong for computer-based jobs. “If there is an elevated risk to white-collar workers, it’s not large,” he said.

    Computer use is clearly linked to RSIs in general, however. A 2019 meta-analysis in Occupational & Environmental Medicine found an increased risk of musculoskeletal symptoms with more screen work (though it does acknowledge that the evidence is “heterogeneous” and doesn’t account for screen use after 2005). Ergonomics experts and occupational-health specialists told me they are certain that many journalists and other professionals did sustain serious RSIs while using 1980s-to-mid-’90s computer workstations, with their fixed desks and chunky keyboards. But the total number of such injuries may have been distorted at the time, and many computer-related “carpal tunnel” cases in particular were spurious, with misdiagnoses caused in part by an unreliable but widely used nerve-conduction test. “It seems pretty clear that there wasn’t a sudden explosion of carpal tunnel cases when the reported numbers started to go up,” Leslie Boden, an environmental-health professor at the Boston University School of Public Health, told me.

    Such mistakes were probably driven by the “crippled by computers” narrative. White-collar workers with hand pain and numbness might have naturally presumed they had carpal tunnel, thanks to news reports and the chatter at the water cooler; then, as they told their colleagues—and reporters—about their disabilities, they helped fuel a false-diagnosis feedback loop.

    It’s possible that well-intentioned shifts in workplace culture further exaggerated the scale of the epidemic. According to Fredric Gerr, a professor emeritus of occupational and environmental health at the University of Iowa, white-collar employees were encouraged during the 1990s to report even minor aches and pains, so they could be diagnosed—and treated—earlier. But Gerr told me that such awareness-raising efforts may have backfired, causing workers to view those minor aches as harbingers of a disabling, chronic disease. Clinicians and ergonomists, too, he said, began to lump any pain-addled worker into the same bin, regardless of their symptoms’ severity—a practice that may have artificially inflated the reported rates of RSIs and caused unnecessary anxiety.

    Henriques, whose symptoms were consistent and severe, underwent a nerve-conduction test not long after her pain and disability began; the result was inconclusive. She continues to believe that she came down with carpal tunnel syndrome as opposed to another form of RSI, but chose not to receive surgery given the diagnostic uncertainty. New York Times reporters with RSIs were not at risk of getting fired, as she saw it, but of ending up in different roles. She didn’t want that for herself, so she adapted to her physical limitations, mastering the voice-to-text software that she has since used to dictate four books. The most recent came out in September.

    As it happens, a very similar story had played out on the other side of the world more than a decade earlier.

    Reporters in Australia began sounding the alarm about the booming rates of RSIs among computer users in 1983, right at the advent of the computer revolution. Some academic observers dismissed the epidemic as the product of a mass hysteria. Other experts figured that Australian offices might be more damaging to people’s bodies than those in other nations, with some colorfully dubbing the symptoms “kangaroo paw.” Andrew Hopkins, a sociologist at the Australian National University, backed a third hypothesis: that his nation’s institutions had merely facilitated acknowledgement—or stopped suppressing evidence—of what was a genuine and widespread crisis.

    “It is well known to sociologists that statistics often tell us more about collection procedures than they do about the phenomenon they are supposed to reflect,” Hopkins wrote in a 1990 paper that compared the raging RSI epidemic in Australia to the relative quiet in the United States. He doubted that any meaningful differences in work conditions between the two nations could explain the staggered timing of the outbreaks. Rather, he suspected that different worker-compensation systems made ongoing epidemics more visible, or less, to public-health authorities. In Australia, the approach was far more labor-friendly on the whole, with fewer administrative hurdles for claimants to overcome, and better payouts to those who were successful. Provided with this greater incentive to report their RSIs, Hopkins argued, Australian workers began doing so in greater numbers than before.

    Then conditions changed. In 1987, Australia’s High Court decided a landmark worker-compensation case involving an RSI in favor of the employer. By the late 1980s, the government had discontinued its quarterly surveillance report of such cases, and worker-comp systems became more hostile to them, Hopkins said. With fewer workers speaking out about their chronic ailments, and Australian journalists bereft of data to illustrate the problem’s scope, a continuing pain crisis might very well have been pushed into the shadows.

    Now it was the United States’ turn. Here, too, attention to a workplace-injury epidemic swelled in response to institutional behaviors and incentives. And then here, too, that attention ebbed for multiple reasons. Improvements in workplace ergonomics and computer design may indeed have lessened the actual injury rate among desk workers during the 1990s. At the same time, the growing availability of high-quality scanners reduced the need for injury-prone data-entry typists, and improved diagnostic practices by physicians reduced the rate of false carpal tunnel diagnoses. In the blue-collar sector, tapering union membership and the expansion of the immigrant workforce may have pushed down the national number of recorded injuries, by making employees less inclined to file complaints and advocate for their own well-being.

    But America’s legal and political climate was shifting too. Thousands of workers would file lawsuits against computer manufacturers during this period, claiming that their products had caused injury and disability. More than 20 major cases went to jury trials—and all of them failed. In 2002, the Supreme Court ruled against an employee of Toyota who said she’d become disabled by carpal tunnel as a result of working on the assembly line. (The car company was represented by John Roberts, then in private appellate-law practice.) Meanwhile, Republicans in Congress managed to jettison a new set of OSHA ergonomics standards before they could go into effect, and the George W. Bush administration ended the requirement that employers separate out RSI-like conditions in their workplace-injury reports to the government. Unsurprisingly, recorded cases dropped off even more sharply in the years that followed.

    Blue-collar workers in particular would be left in the lurch. According to M. K. Fletcher, a safety and health specialist at the AFL-CIO, many laborers, in particular those in food processing, health care, warehousing, and construction, continue to suffer substantial rates of musculoskeletal disorders, the term that’s now preferred over RSIs. Nationally, such conditions account for an estimated one-fifth to one-third of the estimated 8.4 million annual workplace injuries across the private sector, according to the union’s analysis of Bureau of Labor Statistics reports.

    From what experts can determine, carpal tunnel syndrome in particular remains prevalent, affecting 1 to 5 percent of the overall population. The condition is associated with multiple health conditions unrelated to the workplace, including diabetes, age, hypothyroidism, obesity, arthritis, and pregnancy. In general, keyboards are no longer thought to be a major threat, but the hazards of repetitive work were always very real. In the end, the “crippled by computers” panic among white-collar workers of the 1980s and ’90s would reap outsize attention and perhaps distract from the far more serious concerns of other workers. “We engage in a disease-du-jour mentality that is based on idiosyncratic factors, such as journalists being worried about computer users, rather than prioritization by the actual rate and the impact on employment and life quality,” Gerr, the occupational- and environmental-health expert at the University of Iowa, told me.

    As for today’s potential “hazards at the keyboard,” we know precious little. Almost all of the research described above was done prior to 2006, before tablets and smartphones were invented. Workplace ergonomics used to be a thriving academic field, but its ranks have dwindled. The majority of the academic experts I spoke with for this story are either in the twilight of their careers or they’ve already retired. A number of the researchers whose scholarship I’ve reviewed are dead. “The public and also scientists have lost interest in the topic,” Pieter Coenen, an assistant professor at Amsterdam UMC and the lead author of the metaanalysis from 2019, told me. “I don’t think the problem has actually resolved.”

    So is there substantial risk to workers in the 2020s from using Slack all day, or checking email on their iPhones, or spending countless hours hunched at their kitchen tables, typing while they talk on Zoom? Few are trying to find out. Professionals in the post-COVID, work-from-home era may be experiencing a persistent or resurgent rash of pain and injury. “The industrial disease of the information age” could still be raging.

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    Benjamin Ryan

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  • Is This Premenstrual Condition a Mental Illness or Oppression?

    Is This Premenstrual Condition a Mental Illness or Oppression?

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    This article originally appeared in Undark Magazine.

    For one week of every month, I have a very bad time. My back aches so badly I struggle to stand up straight. My mood swings from frantic to bleak. My concentration flags; it’s difficult to send an email. Then, my period starts, and the curse is lifted. I feel okay again.

    Like some 1 to 7 percent of menstruating women, I meet the criteria for premenstrual dysphoric disorder, or PMDD. According to the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR), a person with PMDD experiences marked emotional changes—such as sadness, anger, or anxiety—and physical or behavioral changes—such as difficulty concentrating, fatigue, or joint pain—in the week before their period. PMDD can also affect trans men and nonbinary people who menstruate.

    When I first heard of PMDD, it was a revelation. Here was a concrete explanation for the pain and stress I was feeling every month. Better yet, there was a simple, effective treatment: common antidepressant drugs called selective serotonin reuptake inhibitors, or SSRIs, which can be prescribed for people to take only in the two weeks before their period. Birth-control pills, cognitive behavioral therapy, and calcium supplements may also help.

    Then I heard about the controversy surrounding the diagnosis. When the American Psychiatric Association added a form of PMDD as a proposed disorder to the diagnostic manual in the 1980s—DSM-III-R—some scholars pushed back. They saw the diagnosis as part of the historical oppression of women, done in the name of mental health. The controversy reared up again as PMDD remained in the 1994 DSM-IV, where it was also listed under “Depressive Disorder Not Otherwise Specified.” Many people who menstruate experience emotional changes during their cycles, so defining it as a mental illness could have serious personal and societal consequences, critics argued. A 2002 Monitor on Psychology article, “Is PMDD real?,” quoted the late psychologist and author Paula Caplan: “Women are supposed to be cheerleaders,” she said. “When a woman is anything but that, she and her family are quick to think something is wrong.”

    In the end, the APA weighed these concerns and pushed ahead, adding PMDD to the DSM-5 as an official diagnosis in 2013. But I found the criticism disquieting. Had I embraced a modern hysteria diagnosis? Were the symptoms I experienced even real?

    Researchers have looked for hormonal differences between people who experience severe premenstrual distress and people who don’t. In some cases, they’ve found them: A 2021 meta-analysis found that people with PMDD tend to have lower levels of estradiol, a form of estrogen, between ovulation and menstruation. But other studies have shown little to no difference in hormone levels. “There are no biomarkers. There’s no test that can be done which helps identify someone with PMDD,” says Lynsay Matthews, who researches PMDD at University of the West of Scotland.

    Instead, to receive treatment, people experiencing premenstrual distress have to monitor their own mind and body. PMDD diagnosis is based on a symptom diary kept over the course of multiple menstrual cycles.

    The symptoms recorded in those diaries can be severe. In a 2022 survey, 34 percent of people with PMDD reported a past suicide attempt. More than half reported self-harm. “If someone has suicidal ideation or self-harm, or suicide attempts every month for 30 years, that wouldn’t be described as a normal female response to the menstrual cycle,” Matthews says.

    There is evidence that SSRIs work for people with PMDD, in ways researchers don’t fully understand. “In some cases, hours after taking an effective SSRI, people can feel a lot better,” Matthews says, referring to PMDD patients. In contrast, people with depression usually need to take SSRIs for weeks before feeling the effects. Researchers know the drugs’ mechanism of action is different for PMDD—they just don’t know why. “When people find that out, they find it quite validating that it is a medical condition,” Matthews says.

    Tamara Kayali Browne, a bioethicist at Deakin University, in Australia, agrees that some people experience serious distress in the week before their period—but disagrees with calling it a mental illness.

    “The crux of the problem seems to be that we are in a patriarchal society that treats women very differently and puts a lot of women under a lot of significant, disproportionate stress,” Browne says. That disproportionate stress begins early. Eighty-three percent of a sample of Australian PMDD patients reported trauma in early life. It continues in adulthood. A Swedish survey of 1,239 people with PMDD found that raising children was associated with higher rates of premenstrual distress.

    Between ovulation and menstruation, many people experience higher physical and emotional sensitivity. They may feel unwilling or unable to deal with the stressors they tolerate the rest of the month: the screaming baby, the messy partner. “Is it the time of the month where the truth comes out?” Browne suggests. Seen in this light, irritability, anxiety, and low mood are understandable reactions to life stressors, not symptoms of mental illness.

    There is a long history of doctors labeling women crazy. There is also a long history of doctors dismissing women’s pain. Debates about premenstrual distress are caught in the middle.

    When critics question PMDD and the less severe premenstrual syndrome, it can feel invalidating. “It’s time to stop questioning whether women’s experiences are real and instead start making them real priorities,” the journalists Emily Crockett and Julia Belluz wrote in response to an article that suggested PMS is culturally constructed.

    At the same time, when left unchecked, casual sexism can seep into the medical discourse around PMDD. Early pharmaceutical advertisements marketing SSRIs for PMDD show how this works in practice. In 2000, Eli Lilly packaged fluoxetine hydrochloride in a pink-and-purple capsule and branded it Sarafem. Advertisements for the drug featured incapable, unreasonable women; one fights a shopping cart, another bickers with her (male) partner. “Think it’s PMS? Think again. It could be PMDD.” (The Sarafem brand has since been discontinued.)

    What if we can question the structural factors that make life harder for women while providing medical support for people who are suffering? Could the critiques lead us to more, not fewer, options for people with PMDD?

    Medical interventions can be lifesaving for people with PMDD. But they don’t address a society that places a heavy burden on the shoulders of people assigned female at birth.

    Browne compares severe premenstrual distress to a broken leg. “If you have a broken leg, you really do need painkillers, because you’re experiencing pain,” she says. “But it’s not going to be helpful in the long term if you don’t deal with whatever the underlying cause is.” In the week before menstruation, the life stressors a person with PMDD deals with the rest of the month can feel unbearable. Those life stressors can and should be addressed alongside conventional medical treatment.

    One common stressor is the caregiving load. “Parenting is not only a massive trigger, but it’s also the biggest burden or the biggest guilt that comes with having PMDD,” Matthews says. “Not only are you struggling yourself every month, but you also feel as though you’re failing your children every month.” The co-parent can help alleviate this burden. When fathers spend more time with their kids—and doing child-related chores—mothers tend to be less stressed about parenting.

    Another stressor is relationship difficulties. The emotional changes that come with the premenstrual phase can make conflict with a partner more likely. They can also prompt the PMDD sufferer’s partner to dismiss those feelings. “Nowadays, a partner might still be inclined to say, ‘Wait a minute, I know it’s that time of your month again. You’re just being oversensitive,’” Browne points out. Women in relationships with women, who tend to be more understanding of premenstrual change than men, report a more positive experience of the week before their period.

    Researchers have done great, necessary work to understand PMDD, work that should continue. How are people who experience premenstrual distress biologically different from people who don’t? Can we find new, more effective drugs to treat that distress?

    In the meantime, we need to build a better world for people who experience premenstrual distress. Doctors can prescribe medicine, but managers can make accommodations in the workplace. Co-parents can take on more caregiving responsibility. And partners can provide love and support.

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    Ciara McLaren

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