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Tag: magic mushrooms

  • Elementary students hospitalized after eating magic mushroom chocolate girl took from mom’s fridge, charges say

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    Minneapolis’ Lake Street sees 2 mass shootings in 1 day, and more headlines



    Minneapolis’ Lake Street sees 2 mass shootings in 1 day, and more headlines

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    A Wright County, Minnesota, woman is facing charges after police say two elementary school students overdosed on hallucinogenic mushrooms.

    Court documents say a 6-year-old and another young girl were taken to the hospital last week.

    School staff says the girls started acting strangely after snack time. They later found a wrapper for a chocolate bar containing the mushrooms.

    One of the girls told police she took the chocolate from her mom’s fridge. 

    The girl’s mother, who is 39, was charged with one count each of fifth-degree drug possession, storing meth paraphernalia in the presence of a child and child endangerment, according to a complaint filed Friday.

    During a search of the mother’s apartment, charges say investigators found drug paraphernalia throughout the residence, including three glass pipes that field-tested positive for methamphetamine. 

    Law enforcement also allegedly found meth near a children’s cup and children’s undergarments. In addition to the meth, fentanyl was also within reach and accessible to a child, charges state.

    Court documents show the woman was recently placed on probation and ordered not to use or possess controlled substances.

    As of Tuesday, a warrant is still out for the woman’s arrest.

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    WCCO Staff

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  • Blue Honey: What Is It and How To Make It

    Blue Honey: What Is It and How To Make It

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    Mary Ekundayo

    Posted by Mary Ekundayo on 03/15/2024 in Alternative Medicine

    Blue Honey: What Is It and How To Make ItBlue Honey: What Is It and How To Make It

    If you have taken magic mushrooms before, then you can attest to their not-so-pleasant raw taste. However, did you know that there are ways to make your shroom experience more enjoyable? For example, you can brew them like tea to drink, cook them with other foods, or grind them to swallow in magic capsules.

    One other tasty solution for your mushrooms is to transform them into blue honey, also called magic mushroom honey. In this article, you’ll learn all you need to know about this sweet psychedelic delight. The most exciting part? You’ll learn how to make a jar or two for yourself. Let’s get started.

    What Is Blue Honey?

    In simple terms, blue honey refers to honey that is infused with psilocybin. Compared with other techniques of extracting psilocybin from psychedelic mushrooms, this honey is easy to prepare, store, and dose.

    The reason it’s called blue is because, more often than not, when it is prepared, one part of it turns blue. The prevailing explanation behind this phenomenon is that psilocin, the compound behind the psychedelic effect of psilocybin, turns blue whenever it’s exposed to oxygen.

    If this theory is true, the implication is that the bluer your honey, the less psychoactive it might be. The same can be said for mushroom tea. It turns into a more vibrant blue the longer the liquid is exposed to air.

    How To Make Blue Honey

    Blue honey is simple to make as long as you have mushrooms are available. Check out our guide on how to prepare yours in the comfort of your home.

    Ingredients

    • Honey (preferably runny honey)
    • Dried magic mushrooms
    • Coffee grinder or knife
    • Airtight glass jar

    Directions

    1. Grind the shrooms into fine powder to make it easy for the honey to extract the psilocybin.
    2. Pour in the honey and ground mushroom powder into the glass jar in alternate layers. You can start with a layer of magic mushrooms, then a layer of honey. Repeat this process until the ingredients are exhausted.
    3. Next, transfer the layered mixture into a bowl and mix thoroughly.
    4. Pour the mixture back into the glass jar, then store it in a cool and dry place for at least one month.

    How To Enjoy Blue Honey

    Blue honey is very versatile and can be enjoyed in so many ways. You can: 

    • Add it to your toast.
    • Add it to your cup of tea. However, ensure your hot tea cools down before adding your blue honey.
    • Add it to other foods that you normally take with honey.
    • Simply eat it on its own. 

    Benefits Of Blue Honey

    If you are skeptical about exploring blue honey, there are some upsides of this magic food that might change your mind. It tastes delicious, it is easy to microdose on blue honey, and its preparation doesn’t require any cooking. Its versatility makes it easy to add to a number of foods so you can choose your own adventure every time. 

    Other Things To Note About Blue Honey

    Following these practices will help you end up with high-quality magic mushroom honey:

    • Ensure you use thoroughly dry mushroom stems to make your honey last longer.
    • For a more potent result, use more magic mushroom powder.
    • The psilocybin potency is typically preserved for up to many years without degradation if it’s kept away from light, heat, and oxygen.

    When Not To Take Blue Honey

    The blue honey psilocybin experience is nothing short of powerful and rewarding. Nonetheless, you might need to steer clear of taking it if you are:

    • on prescription pills
    • experiencing anxiety, depression, or other forms of mental stress
    • pregnant or breastfeeding

    How To Know Your Blue Honey Dosage

    The psychedelic effect of your blue honey largely depends on the amount of the mushroom you use, so the potency will be different for different people. As such, you can only determine your dosage by consuming the honey in bits and monitoring its effect on you. Start small and work your way up to larger amounts. 

    After figuring this out once, you can tell how powerful your magic mushroom honey is and the safest quantity to take per time.

    Alternative Ways to Consume Mushrooms

    As you read through this article, you must have noticed that we mentioned other ways to make your magic mushroom less boring to consume. After trying out our blue honey recipe, feel free to explore the other options we have outlined below.

    Magic Mushrooms Capsules

    With handy tools like a capsule machine, empty capsules, and ground shrooms, you’ll get these done in no time. Pour the magic mushroom powder into the empty capsules and close them up using the capsule machine. Voila! Your capsules are ready to be swallowed. You can typically dose these out more accurately as well. 

    Magic Mushrooms Edibles

    You can add magic mushrooms to almost any food that you eat. However, the catch is never to add it during any cooking process to avoid destroying the psilocybin. For example, you can add shrooms to your sauces and toppings after cooking them. Other popular options include adding it to ice cream or a peanut butter and jelly sandwich. 

    Magic Mushrooms Tea

    Do the following to make a cup of shroom tea:

    • Cut your magic mushrooms into small pieces and throw them into a pan of hot water.
    • Let the shrooms simmer for about 20 minutes. Don’t let the water boil to preserve the psychedelic effect of the plant.
    • Strain out the mixture into a cup to get rid of the mushroom stems. 
    • Feel free to add ginger, honey, and other additives you normally put in your tea.

    Lemon Tek

    Lemon tekking is an increasingly popular way to consume shrooms. Some people claim it makes them stronger, but there is little scientific evidence to support this as of yet. Regardless, it’s a tasty and easy way to take shrooms. Here’s how it’s prepared:

    • Add some lemon juice to a glass cup.
    • Pour your ground magic mushrooms into the cup.
    • Let the mixture sit for some time.
    • Add some water and gulp down the drink. 

    Double Delight

    Magic mushroom honey is the perfect blend of the tasty honey world and the psychedelic adventure. Instead of dealing with bone-dry shroom stems, you get to enjoy them in a delicious way.

    However, just as you would do with any other psychedelic, ensure you start small when consuming blue honey to avoid overdosing. A good practice is to start with one teaspoon and slowly increase the quantity based on your tolerance level.

    Enjoy!

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  • How To Make Mushroom Chocolate at Home

    How To Make Mushroom Chocolate at Home

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    Mary Ekundayo

    Posted by Mary Ekundayo on 03/21/2024 in Alternative Medicine

    How To Make Mushroom Chocolate at HomeHow To Make Mushroom Chocolate at Home

    What better way to transform the not-so-tasty magic mushroom into a sweet chocolatey delight than by making mushroom chocolate? 

    If you’ve ever eaten shrooms, then you can attest that they have a rather unpleasant flavor and texture. Of course, this doesn’t in any way affect their medicinal value, but people can be discouraged from benefiting from their worth because of their taste.

    In this article, we’ll show you how to use chocolate to make magic mushrooms into a delicious wonder. The most exciting part? You can get it done at home!

    Health Benefits of Chocolate

    One major ingredient in chocolate that is responsible for its health benefits is cocoa. Pure cocoa creates similar results in our body and mind as magic mushrooms, however, at lower levels. As such, the effects of chocolate can include: 

    • Reducing stress levels: Cocoa influences our serotonin system to reduce stress levels, which causes a greater feeling of tranquility.
    • Combating depression: Because it activates oxytocin (or the love hormone) in our brains, chocolate functions as a natural antidepressant.
    • Stimulating the central nervous system (CNS): Chocolate contains theobromine, which improves blood flow in the muscles. This, in turn, enhances alertness, cognitive function, and the delivery of oxygen to the brain. 

    Chocolate + Magic Mushroom: How Safe Is It?

    Chocolate made from pure cocoa functions as mild monoamine oxidase inhibitors or MAOIs. Many antidepressants are MAOIs, which prevent the removal of serotonin and dopamine from the brain. As opposed to mixing stronger MAOIs with shrooms, which can have some unpleasant results, chocolate is safe to use with magic mushrooms. 

    Most of the chocolates you’ll find at stores today are made from refined cocoa. To get the best mushroom chocolate, it is ideal to use some raw cocoa.

    Before Getting Started: A Note On Psilocybin

    The psilocybin in mushrooms doesn’t do well with heat. In fact, it begins to break down around 70°C, which can ultimately ruin its effect. Irrespective of what you want to cook or prepare, you shouldn’t go beyond this temperature.

    The best way to preserve psilocybin is to cook any ingredient that needs heat first and add mushrooms after the heat is gone. So, whether it’s tea you want to add your shrooms into, ensure the water is cooled off first. Similarly, for mushroom chocolate, it’s best to melt the chocolate and then add shrooms when the heat is gone.

    How To Make Magic Mushroom Chocolate

    Once you have your ingredients set, magic mushroom chocolate is pretty easy to make. Here are the resources you’ll need and how to get it done.

    Ingredients and Equipment

    • Cracker-dry magic mushrooms
    • Bars of your favorite chocolate
    • Raw cocoa (optional)
    • A glass or metal bowl
    • A large saucepan
    • Stirring spoon
    • A coffee grinder or sharp knife
    • Baking tray (non-stick)
    • Candy or alcohol thermometer (optional)

    Instructions

    1. Cut or grind the mushrooms into smaller pieces. The smaller they are, the better.
    2. Break your chocolate into smaller chunks and place them in the glass or metal bowl.
    3. To melt the chocolate, pour some water into the saucepan. Then, transfer the bowl with the chocolate into the pan, and ensure there’s about an inch or more space between the water and the base of the bowl.
    4. Bring the saucepan to boil over low heat so that the steam will cause the chocolate in the bowl to melt. You can aid the process by gently stirring the chocolate with a stirring spoon.
    5. Alternatively, you can melt the chocolate by placing the bowl in a microwave and heating it at intervals of 30 seconds so it doesn’t get burnt. 
    6. After melting the chocolate, allow it to cool down to below 70°C. You can use a candy or alcohol thermometer to ascertain the temperature.
    7. Once the chocolate is below 70°C (and still liquid), add the ground mushrooms and the cocoa powder.
    8. Stir the mixture until the content is evenly distributed.
    9. Scoop out the mix in molds onto the baking tray and place in the fridge to cool.
    10. Once it’s cool and solid, your mushroom chocolate is ready to eat!

    Tip: You can also make magic truffles chocolate by following the same process for mushroom chocolate. Additionally, any extra flavoring you want to add should be oil-based and melted separately so it’s easy to mix.

    Carefully Dose Your Mushroom Chocolate

    In practice, it is a bit difficult to tell the exact dose of shrooms in your chocolate. However, a good rule of thumb is to use one dose of mushrooms for a portion of mushroom chocolate. You can then scale it up based on the number of times and the number of people who would eat the shroom chocolate.

    If it’s your first time trying this recipe out, it’s advisable to go even lower with your first dose. Over time, you’ll know the dosage that best suits you.

    Mushroom Chocolate Effects  

    Magic mushrooms are known for the euphoric high they cause. As such, you should expect the psychedelic and relaxing effect of the shrooms after eating the chocolate.

    However, it typically takes about 30 minutes for the effect to kick in. In fact, some varieties of mushrooms can take up to 45 minutes to 1 hour before you feel anything. Therefore, it is best to wait at least an hour before eating more magic chocolate.

    How Long Do Magic Mushrooms Last?

    The truth is that the lifecycle of mushroom chocolate depends largely on how you store the chocolate. If you seal it and store it in a cool and dark place, it can last up to a year while retaining the psychoactive properties of the shrooms.

    Fun fact: While chocolate could have a funny taste with time, it never really spoils.

    Go Create Magic!

    Making magic mushroom chocolate is an easy, delicious, and rewarding journey to embark on. Moreover, the raw cocoa further enhances the stimulating effect of the shrooms.

    Note that this recipe is just a foundation. You can explore the addition of other ingredients like nuts and dried fruits. So, if you love chocolate and also want to try magic mushrooms, what are you waiting for? Go create magic today.

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  • Poison center calls spiked after magic mushrooms were decriminalized

    Poison center calls spiked after magic mushrooms were decriminalized

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    Calls to poison control centers spiked across the U.S. for adolescents and young adults exposed to the hallucinogen psilocybin, according to our analysis of data from 55 U.S. poison centers between 2013 and 2022. The calls increased after 2019 when psilocybin was decriminalized and legalized in several cities and states…

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    Christopher P. Holstege and Rita Farah | The Conversation

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  • Mushroom dreams: Arizona lawmakers signal support for psilocybin use

    Mushroom dreams: Arizona lawmakers signal support for psilocybin use

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    Arizona lawmakers have mushrooms on their mind.

    A bipartisan group of state senators signaled its broad support for a bill making its way through the legislature that legalizes psilocybin mushrooms under controlled, therapeutic settings. Studies have found that psilocybin can be useful in treating mental illnesses such as post-traumatic stress disorder and depression.

    The Arizona Senate passed Senate Bill 1570 on Feb. 29 by a vote of 24-4, with two members not voting. The bill moved to the House and was assigned to the Heath and Human Services Committee on Monday.

    Two weeks before the Senate vote, the Senate Health and Services Committee voted unanimously to recommend approval of the bill. Republican state Sen. Thomas “T.J.” Shope, the principal sponsor of the bill, led the hearing.

    “We just had a press conference on this issue out on the lawn that was probably the most well-attended press conference we’ve had all session long,” Shope said during the Feb. 13 meeting. “That tells me there is a desire to explore what treatment for PTSD looks like other than what is already available to Arizonans.”

    Psychedelic-assisted therapy is not limited to treatment for PTSD. The Arizona Department of Health Services was allotted $5 million in 2023 from the state’s $18 billion budget to conduct clinical trials on the effects of psilocybin mushrooms in treatment for autoimmune disorders, depression, anxiety, substance abuse and chronic pain, among other conditions. The $5 million in funding came after a bill that would have provided $30 million for natural psilocybin research failed to pass.

    A quirk in the funding, though, means that researchers would need to spend grants from the $5 million by the end of the state’s budget year, which is June 30. Supporters of the funding said that’s not enough time. A legislative fix extending the deadline to 2026 — House Bill 2105 — has stalled in the House.

    click to enlarge

    The medical benefits of magic mushrooms are getting serious attention by Arizona lawmakers.

    Daniel Berehulak / Getty Images

    ‘Psilocybin not typically a substance of dependence’

    SB 1570 would establish the Arizona Psilocybin Advisory Board, tasked with approving training programs to license health care professionals in psilocybin-assisted therapy centers. The bill calls for appointments to the APAB to be made by the end of this year.

    According to the bill, the Arizona DHS can begin accepting applications to license health care professionals on Jan. 1, 2026. Only medical doctors, nurse practitioners, physician assistants and naturopaths would be allowed to prescribe psilocybin.

    “During my time as a psychiatric provider, I’ve become acutely aware of how limited our treatment options are for effective mental health interventions, both pharmaceutical and psychotherapeutic,” said Jennifer Montjoy, an Arizona psychiatric nurse practitioner, during the Senate committee meeting in February.

    “Roughly half of patients treated for a major depressive disorder and PTSD do not respond to available treatment options,” she added. “They’re considered treatment-resistant.”

    During the meeting, Montjoy noted that psychedelic-assisted therapy usually consists of one or two sessions. It is meant to be a short-term treatment, in contrast with some forms of talk therapy or prescription medications.

    “Though psilocybin is used recreationally, due to the intensity and duration of high-dose experiences, it’s not typically a substance of dependence,” she said. “It’s also not a substance of ongoing, repeated misuse.”

    Montjoy considers psilocybin a nonaddictive intervention, and she mentioned its potential application for treating anxiety disorders, obsessive-compulsive disorder, end-of-life anxiety and substance misuse, in addition to PTSD. She addressed fears of possible dependence by saying that withdrawal from the use of psychedelics has not been observed in studies.

    Other states have been early adopters of mushroom use. Oregon passed a measure in 2020 that decriminalized hard drugs and allowed psilocybin mushrooms to be used in therapeutic settings. And in 2022, Colorado decriminalized the possession, growing and use of five natural psychedelic substances, including psilocybin. The measure allows for the use of psychedelic mushrooms in licensed facilities by late this year.

    click to enlarge psilocybin mushroom

    A psilocybin mushroom displayed at a growing competition in Denver last November.

    Evan Semón

    Arizona’s opportunity to be a pioneering state

    Jimmy Nguyen is the Colorado-based co-founder of Psychedelic Passage, a site that provides information and referrals to people interested in healing through psychedelics. Both Nguyen and Montjoy acknowledge that embracing the use of psychedelics will not be a magic cure for PTSD or depression, and it isn’t for everyone, though it does provide another tool in addition to traditional treatment options.

    “Arizona has the opportunity to be one of those pioneering states that say, ‘Hey, how does this work for Arizona?’” Nguyen said. “‘How does this work for us and the people who live here?’”

    Nguyen, who has experience both as a facilitator and as a “journeyer” — a user of psychedelics for healing purposes — cited a number of factors to think about when determining whether psychedelics are the right treatment option. These include family attitudes as well as life and medical history.

    When vetting facilitators for his organization, Nguyen looks for certifications and experience with trauma-informed care, as well as first responder skills. Personal experience with psychedelics and a background of caring for clients or journeyers also are important, Nguyen said. A facilitator’s demeanor can affect treatment.

    ”Some psychedelic experiences are full of bliss, love, connection with all and joy,” Nguyen said. “Some others are much more challenging and difficult to navigate through. I find that in those difficult experiences, there can be a lot of learning, a lot of catharsis and potential for growth.”

    Nguyen said clients must feel comfortable; they need to trust the person sitting across from them. “These are experiences that bring up a lot of vulnerable topics,” he added. “These are experiences where individuals can dive really deeply into themselves.”

    Nguyen encourages the use of psychedelic-assisted therapy alongside traditional forms of therapy or medication. He also noted that psilocybin has helped him grapple personally with the inevitability of suffering. The main root cause for most suffering comes from either a feeling of “not enoughness,” he said, or from an individual’s lack of a meaningful relationship with themselves.

    Psychedelics provide an opportunity to dive into the core causes, Nguyen said. “Maybe it’s not addressing the symptom,” he said. “But maybe it’s actually addressing the core reason for why those symptoms exist in the first place.”

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    Noah Cullen

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  • Research Shows Science Behind Psychedelics, Psychotherapy’s Ability To Cause Quick Brain Changes | High Times

    Research Shows Science Behind Psychedelics, Psychotherapy’s Ability To Cause Quick Brain Changes | High Times

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    Psychedelic-assisted psychotherapy merges the principles of talk therapy with the effects of psychedelics. Many people seeking help with depression, PTSD, anxiety, or other mental health conditions have tried one or the other. 

    Some notable research includes looking at the use of psilocybin, one of the psychoactive components of magic mushrooms, to treat anxiety experienced by patients with metastatic cancers. Other studies spotlight the use of psychedelic therapy to help patients receiving hospice care cope with feelings of depression and hopelessness. 

    Such studies suggest that people, especially those with terminal illnesses like cancer, experience profound psychological transformations in a single six-hour session involving psilocybin when combined with psychotherapy. This dual approach results in a drastic improvement in mood and acceptance of one’s situation. 

    And now, neuroscientists understand more about how and why these positive outcomes occur. Research indicates that forming new neural connections facilitates assimilating new skills, memories, and attitudes, PsyPost reports. Known as arborization, this process is comparable to the branching of trees, which it’s named after. This happens when neurons create new pathways. This neural growth is crucial in fostering changes in cognition and emotional responses.

    Scientists use a method known as two-photon microscopy to examine this phenomenon in living cells. This technique lets them monitor the development and retraction of spines on neurons. Prepare for some science, reader: These neuron spines comprise one part of the synapses, essential for facilitating communication between neurons. 

    Scientists widely believed that lasting spine formation in the brain required continuous and repetitive mental effort. But, new research from Yale suggests that it could happen quickly and even in one dosage. The scientists observed swift spine formation in the frontal cortex of mice after just a single dose of psilocybin. Obviously, the mice did not receive therapy and integration. But, the study showed that mice administered with psilocybin exhibited around a 10% increase in spine formation. These changes were not fleeting; they were noted one day post-treatment and then persisted for over a month.

    Psychoactive compounds mainly alter brain activity by interacting with receptors on neural cells. Among these, the serotonin receptor 5HT, commonly targeted by traditional antidepressants, exists in multiple subtypes. So, there’s more than one way to use them to prompt positive change. Psychedelics like DMT (the key ingredient in ayahuasca) activate a specific receptor subtype known as 5-HT2A. Researchers believe this receptor also plays a crucial role in facilitating hyperplastic states, periods when the brain undergoes rapid changes. 

    The 5-HT2A receptors, which DMT activates, are found not only on the surface of neuron cells but also within the neuron itself. The famous internal 5-HT2A receptor is key to igniting the rapid changes in neuronal structure. Serotonin is unable to penetrate the cell membrane, which is why people don’t experience hallucinations when taking antidepressants like Prozac or Zoloft (much to many readers taking the mood-elevators distaste). In contrast, psychedelics can cross the cell boundary and influence the internal 5-HT2A receptor, promoting the growth of dendrites and an increase in spine formation.

    Besides being the active component in ayahuasca, as readers may know, DMT is also a molecule naturally produced in mammalian brains — including humans. 

    The fact that our brains make DMT suggests that human neurons can generate their own ‘psychedelic’ molecules (albeit in minuscule amounts). It’s conceivable that the brain employs its own endogenous DMT as a mechanism for adaptation, such as forming dendritic spines on neurons to embed crucial mental states. Ideally, a patient would use therapy in conjunction with these molecular changes for the best possible outcome when seeking help for a mental health condition. 

    While the brain only makes small amounts of DMT, you may have heard that when we die, there’s a massive burst of it, explaining some of what folks claim to see during near-death experiences. The hypothesis that the brain releases DMT in large quantities at death is a favorite in the psychedelic community; however, it remains a hypothesis without solid scientific backing. Research in this area is challenging not only to any drug laws but also to the ethical and practical difficulties of studying the brain at the moment of death.

    However, the psychedelic community must remember that bad trips do happen, and that’s not something you want happening to you or someone that you love in the final days of your life. As PsyPost points out, in “These Precious Days,” a collection of essays by Ann Patchett, she recounts an experience of consuming mushrooms with a friend who was battling pancreatic cancer. Her friend underwent a spiritual and transformative experience, emerging with a heightened connection to her loved ones. Patchett, however, describes her experience differently, likening it to spending eight hours in a dark, nightmarish scenario, akin to being in a cauldron of lava at the Earth’s core, where she felt as if she was constantly battling snakes. 

    While there’s evidence that psychedelic therapy can do miraculous work, explained by even more miraculous science, even all the Yale researchers and psychonauts in the world can’t prevent with complete certainty the risk of battling snakes in a cauldron of lava at the Earth’s core. 

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    Sophie Saint Thomas

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  • Lawyer says Alaska Airlines pilot was not under the influence of intoxicants

    Lawyer says Alaska Airlines pilot was not under the influence of intoxicants

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    Lawyer says Alaska Airlines pilot was not under the influence of intoxicants – CBS News


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    A lawyer for an off-duty Alaska Airlines pilot who is accused of trying to shut off a plane’s engines midflight said his client was not under the influence of intoxicants at the time. This comes after the pilot allegedly told officers following his arrest that he had taken psychedelic mushrooms about two days prior to the flight, per court documents.

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  • New Research Exploring Psychedelics as a Treatment for Anxiety in Cancer Patients | High Times

    New Research Exploring Psychedelics as a Treatment for Anxiety in Cancer Patients | High Times

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    The use of psychedelics as a treatment for serious mental health conditions continues to gain traction as multiple studies focus on the psychological symptoms commonly experienced by cancer patients. In one study, researchers at the University of Washington are exploring the use of psilocybin, one of the psychoactive components of magic mushrooms, to treat anxiety experienced by patients with metastatic cancers. Other research focuses on using psychedelic therapy to help patients receiving hospice care cope with demoralization. 

    In a separate study at the Center for Psychedelic Medicine at the New York University (NYU) School of Medicine, researchers are conducting a clinical trial using psilocybin-assisted therapy to treat existential distress in patients with advanced-stage cancer in collaboration with colleagues at the University of Colorado. Dr. Xiaojue Hu, a psychiatrist and researcher at NYU’s Center for Psychedelic Medicine, noted that the study “is building on the same work in this area originally done at NYU in the 2010s.” 

    “Now, there are many other studies using psilocybin in cancer patients, including a study using psilocybin in combination with multidisciplinary palliative care to treat demoralized cancer survivors with chronic pain going on at Emory University,” she told SurvivorNet.

    Hu explained that psychedelic-assisted therapy could be a more sustainable and effective treatment for cancer patients than other commonly prescribed alternatives including antidepressants. 

    “From the psilocybin research on depression alone, we’ve seen clinically significant impact from just one or two doses of psilocybin in conjunction with therapeutic support that can last up to 14 months for some patients,” said Hu. “This is in contrast to antidepressants, which people have to take on a daily basis for potentially years, with a risk of relapse when the meds are tapered off.”

    Psilocybin And MDMA For Mental Health

    Clinical research and other studies into psychedelics such as psilocybin and MDMA have shown that the drugs have potential therapeutic benefits, particularly for serious mental health conditions such as depression, PTSD, substance misuse disorders and anxiety. In January, a California biopharmaceutical company announced positive results from a clinical trial testing MDMA as a treatment for PTSD. Research published in the peer-reviewed journal JAMA Psychiatry in 2020 found that psilocybin-assisted psychotherapy was an effective and quick-acting treatment for a group of 24 participants with major depressive disorder. A separate study published in 2016 determined that psilocybin treatment produced substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer.

    Although the research is promising, Hu said that psychedelic-assisted therapy does not work for everyone and that further research is needed to confirm the efficacy and safety of the treatment.

    “Psychedelics aren’t a panacea or miracle cure for anxiety and depression, as there’s still much that’s unknown about them and there’s always the potential for adverse effects, like with any treatment,” Dr. Hu said.

    Hu added that research has focused on using psychedelic treatments in conjunction with multiple sessions that integrate more traditional forms of therapy.

    “Most of the research is also done when psychedelics, such as psilocybin, are used in the context of therapeutic support with usually two therapists, which can include up to three sessions of preparation and three sessions of integration afterwards,” she said. “So the results are not completely due to the physiologic effects of psilocybin alone, in my opinion, but must be taken into context with the therapeutic and environmental support that’s also offered.”

    Hu also noted that psychedelic-assisted therapy is conducted in a tightly controlled environment because the set and setting in which a patient receives the treatment can have an impact on its success.

    “We typically don’t expect different results if someone took their Lexapro [an antidepressant] in different moods, with different people, or in different environments, but we definitely can when it involves psychedelics,” she said.

    While the research continues, the use of psychedelics to treat serious mental health conditions such as anxiety and depression has yet to achieve approval from health regulators. The U.S. Department of Health and Human Services projects that the Food and Drug Administration will eventually approve MDMA and psilocybin mental health treatments, according to a letter from the department in May 2022. In 2017, the FDA granted MDMA-assisted therapy Breakthrough Therapy designation, indicating that the therapy is a significant improvement over existing treatments. 

    The Multidisciplinary Association for Psychedelic Studies (MAPS) predicts that an application to use MDMA to treat PTSD will be submitted to the FDA at some point in 2023, and approval could come as early as 2024. But so far, MDMA-assisted therapy has not been approved by any regulatory agency and the safety and efficacy of MDMA-assisted therapy for the treatment of PTSD have not been firmly established.

    “MDMA and psilocybin have the most clinical research and legal momentum behind them right now, with psilocybin already being legalized in Oregon and Colorado and MDMA phase III trials recently being completed,” said Hu.

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    A.J. Herrington

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  • Colorado Says Yes to Medical Use of ‘Magic Mushrooms’

    Colorado Says Yes to Medical Use of ‘Magic Mushrooms’

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    By Cara Murez 

    HealthDay Reporter

    MONDAY, Nov. 14, 2022 (HealthDay News) – Colorado voters have voted narrowly to approve the medical use of “magic mushrooms” in Colorado.

    “I’m in awe of what we were able to accomplish,” said Veronica Lightning Horse Perez, a lead proponent for legalizing psilocybin, the main psychoactive compound in mushrooms. “Over a million people voted yes on this. To think that many people see the value in these medicines, that many people know that these can be used for healing — that’s huge.”

    In 2018, the U.S. Food and Drug Administration called psilocybin a “breakthrough therapy,” which has sped up development of medications using the compound.

    Psilocybin may have potential as a treatment for a host of mental health conditions, including depression, anxiety, post-traumatic stress disorder (PTSD), drug dependency and eating disorders. Clinical trials to further research this are continuing.

    A movement to legalize psilocybin is growing: Oregon voters approved allowing its therapeutic use in 2020, while it has been decriminalized in Washington, D.C. and more than a dozen additional cities, NBC News reported.

    An additional 19 states have seen the introduction of bills to legalize its possession, though none have been approved yet. These include Missouri, Iowa and Kansas. More than a dozen other states are seeking to further study its health benefits, including Florida, NBC News reported.

    Meanwhile, Hawaii’s state Senate has approved assembling a task force that would plan for making the drug available to adults as a mental health treatment. Connecticut has adjusted its state budget to fund programs that would use the drug in working with veterans and retired first responders.

    In Oklahoma’s House of Representatives, a bill to authorize scientific research into psilocybin is headed to the Senate. It would allow state-run clinical trials for adults with specific conditions, NBC News reported.

    “More folks are starting to recognize and understand, when it comes to psychedelic therapy, this is not some sort of radical field. It’s becoming more mainstream,” Oklahoma state Rep. Daniel Pae, who co-authored the bill, told NBC News.

    Texas has already passed a similar bill to study the drug.

    Meanwhile, psilocybin remains illegal at the federal level and in most states, NBC News reported.

    Importantly, the new Colordao law does not allow retail sales or use in various circumstances, including schools, in public or while operating a vehicle.

    Denver-based addiction counselor Kevin Franciotti told NBC News that the measure gives Colorado the “opportunity to be a leader in pushing American drug policy in the right direction.”

    Still, opponents of the Colorado measure called for not jumping ahead of FDA approval.

    “I’m hoping the rest of the country can learn the hard lessons from my state’s foray,” Luke Niforatos, who leads two national organizations that opposed the measure. “As the years go on and we learn more about this experiment, hopefully we’ll say we’re going to let the FDA and scientists lead medicine, not corporations.”

    More information

    The National Library of Medicine has more on psilocybin as a therapeutic.

     

     

    SOURCE: NBC News

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