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Tag: ketamine

  • L.A. home where Matthew Perry died sells for $8.55 million

    L.A. home where Matthew Perry died sells for $8.55 million

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    Matthew Perry’s former Pacific Palisades home has been sold in an $8.55-million, off-market deal — almost a year to the day since the actor was found dead on the property.

    The four-bedroom, 3,500-square-foot, mid-century modern home was sold to Anita Verma-Lallian, a movie producer and real estate developer based in Scottsdale, Ariz., a representative told The Times. She intends to use the property as a vacation home, her representative said.

    Perry purchased the property in 2020 for $6 million, records show.

    Verma-Lallian bought the home through a trust and was represented by Brooke Elliott Laurinkus of Christie’s International Real Estate Southern California, her representative said. The listing was held by Greg Holcomb of Carolwood Estates, he added.

    Perry was found unresponsive in his backyard hot tub in October 2023. While his death at 54 was initially classified as a drowning, an autopsy revealed that the level of ketamine in his blood was about the same as would be used during general anesthesia.

    In August, Perry’s live-in personal assistant, two doctors and two alleged drug dealers — one known as the “Ketamine Queen” — were charged with providing ketamine that led to Perry’s death.

    Ketamine is a legal medication commonly used as an anesthetic, but is also abused recreationally for its calming and dissociative effects. Federal prosecutors allege that the defendants took advantage of Perry’s addiction to enrich themselves.

    News of Perry’s death was met with an outpouring of grief. The beloved comedic actor starred as Chandler Bing in all 10 seasons of the hit sitcom “Friends.”

    Verma-Lallian received her MBA from USC and is the founder and chief executive of a commercial real-estate consulting firm called Arizona Land Consulting, which specializes in securing and developing land in the Greater Phoenix area.

    In August, she facilitated a $136-million purchase of a 2,100-acre site to house data centers for the AI-powered platform Tract. That same month, she closed two real-estate deals in Buckeye, Ariz., totaling almost $20 million.

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    Clara Harter

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  • Doctor who helped supply Matthew Perry with ketamine pleads guilty

    Doctor who helped supply Matthew Perry with ketamine pleads guilty

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    One of two doctors charged with supplying ketamine to Matthew Perry pleaded guilty Wednesday to illegally distributing the surgical anesthetic.

    Dr. Mark Chavez is among three defendants who signed a plea deal and are facing lesser charges in Perry’s death, which federal prosecutors chalked up to a conspiracy by multiple individuals to provide the actor with the drug.

    The two other defendants who have entered into plea agreements are Perry’s live-in personal assistant, Kenneth Iwamasa, and alleged drug dealer Erik Fleming.

    Two other defendants are not cooperating with prosecutors and face far more serious conspiracy charges.

    Jasveen Sangha, aka the “Ketamine Queen,” presented herself as “a celebrity drug dealer with high quality goods,” according to court documents. She’s accused of supplying Perry’s assistant with ketamine. Dr. Salvador Plasencia, referred to as “Dr. P,” allegedly injected the actor with the drug at his Pacific Palisades home. Both have pleaded not guilty and are set to be tried in March.

    During a brief appearance in federal court in Los Angeles on Wednesday, Chavez was asked how he pleaded and replied, “Guilty, your honor.” He is due back for sentencing in April and could face up to 10 years in federal prison. As part of his plea, Chavez agreed to surrender his medical license. He is free on $50,000 bond.

    Perry, 54, was found dead in the hot tub of his Pacific Palisades home on Oct. 28. He died from “acute effects of ketamine,” according to the Los Angeles County Medical Examiner’s Office. His death triggered a multiple-agency federal investigation.

    Prosecutors last month revealed charges against what U.S. Atty Martin Estrada dubbed a “broad underground criminal network” that supplied the actor.

    In late September, about a month before Perry’s death, prosecutors allege, Plasencia learned the actor was interested in obtaining ketamine, a legal medication commonly used as an anesthetic, according to charging documents in the case.

    Perry had taken the drug through his regular physician in an off-label treatment for depression. But abusers of the drug use it recreationally, drawn to its dissociative effects.

    After learning of Perry’s interest, Plasencia contacted Chavez, who previously operated a ketamine clinic, to obtain the drug to sell to the actor, authorities said. In text messages to Chavez, Plasencia discussed how much to charge Perry for the ketamine, stating, “I wonder how much this moron will pay” and “Let’s find out,” according to court records. The doctors charged Perry $2,000 for a dose that cost Chavez $12, prosecutors allege.

    Chavez, as part of the plea agreement, admitted to diverting ketamine from his San Diego clinic to sell to Plasencia. Chavez admitted he lied to a drug distributor and submitted a prescription under the name of a former patient without their consent.

    Chavez transferred 22 vials of ketamine and nine ketamine lozenges, which were fraudulently obtained, to Plasencia for sale to Perry. Chavez “was fully aware that selling vials of ketamine to a patient for self-administration was illegal,” according to the plea agreement.

    Plasencia, although forbidden by the Drug Enforcement Administration from prescribing controlled substances, continues to practice medicine but must inform patients about the ongoing criminal case.

    Plasencia is facing one count of conspiracy to distribute ketamine, seven counts of distribution of ketamine and two counts of altering and falsifying documents or records related to the federal investigation. If convicted, he faces 10 years for each ketamine-related charge and 20 years for each falsification charge.

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    Richard Winton

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  • Matthew Perry investigation: What we know about the people charged in his death

    Matthew Perry investigation: What we know about the people charged in his death

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    Two doctors and a live-in personal assistant to Matthew Perry are among the people charged following a months-long investigation into how the prescription drug ketamine that contributed to the actor’s death was procured.

    Prosecutors on Thursday charged five people in connection with the death of the “Friends” star, who was found dead in the hot tub at his Pacific Palisades home on Oct. 28. Trace amounts of ketamine — which is sometimes used to treat depression — were found in his stomach, according to the Los Angeles County medical examiner.

    But the level found in his blood was about the same as would be used during general anesthesia, his autopsy showed.

    Since then, authorities have been working to determine how Perry got the drug, which caused cardiovascular overstimulation and respiratory depression. Ketamine is a legal medication commonly used as an anesthetic, but it can be abused recreationally, with users drawn to it for its disassociative effects.

    The Times reported in June that investigators with the Los Angeles Police Department, the federal Drug Enforcement Administration and the U.S. Postal Service had linked several people to procurement of the ketamine.

    The named defendants in the case include two physicians, Perry’s live-in personal assistant who authorities say injected him with ketamine and a dealer dubbed the “Ketamine Queen” by federal agents.

    Here’s what we know about the people named in the indictment, which was unsealed Thursday:

    Narcotics including methamphetamine and ketamine were seized in a raid on Jasveen Sangha’s North Hollywood home on March 19. Sangha, dubbed the “Ketamine Queen” by investigators, is charged in the death of actor Matthew Perry.

    (U.S. District Court)

    Sangha was arrested in March on narcotics charges and posted a $100,000 bond in a separate case.

    During a raid at Sangha’s home on March 19, authorities seized 1,978 grams of methamphetamine pills, 79 bottles of liquid ketamine, 2,127 grams of pills suspected of being Xanax, 323 grams of a substance suspected of being psilocybin mushrooms and 128 grams of suspected cocaine, according to federal prosecutors. Authorities also found a journal in her home that detailed thousands of dollars in drug transactions, according to Thursday’s indictment.

    Prosecutors say that Perry was not the only victim who overdosed on Sangha’s product.

    In August 2019, she sold ketamine to Cody McLaury hours before his death. One of McLaury’s family members texted Sangha: “The ketamine you sold my brother killed him. It’s listed as the cause of death,” according to court records.

    Days later, according to the records, Sangha searched on Google, “can ketamine be listed as a cause of death[?]”

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    Nathan Solis

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  • Matthew Perry’s Ex Claims He DATED Charlie Sheen’s Ex Brooke Mueller, Who Was Questioned In Friends Star’s Death! – Perez Hilton

    Matthew Perry’s Ex Claims He DATED Charlie Sheen’s Ex Brooke Mueller, Who Was Questioned In Friends Star’s Death! – Perez Hilton

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    Talk about a plot twist here!

    Since last year, the Los Angeles Police Department has been trying to figure out how Matthew Perry got the ketamine that killed him. As we previously reported, the Los Angeles County Medical Examiner’s Office blamed “the acute effects” of the drug as the cause for the heart attack he had in the hot tub. He was undergoing ketamine therapy to treat depression and was closely monitored by medical professionals at the time. However, his last infusion therapy was a week and a half before his death – which means that it did not cause the cardiac arrest “since ketamine’s half-life is 3 to 4 hours or less.” So, the actor must have got the drug from somewhere else. It also meant that he was not 100 percent sober as we all thought!

    At one point, the LAPD’s investigation into this matter led them to a female celebrity who has since been identified by In Touch as Charlie Sheen’s ex-wife Brooke Mueller. She reportedly was questioned “multiple” times by the police about his death in May while she was at a sober living residence and even turned over her laptop and iPhone. She’s cooperating with the investigators, which is good! Although Brooke apparently swears she did nothing wrong, In Touch claimed she already lawyered up.

    Related: Lisa Kudrow Rewatching Friends For This Absolutely Heartbreaking Reason

    As for how Matthew and Brooke know each other? The insider for the outlet said the pair — who both struggled with addiction over the years — “met in rehab” and “formed an unexpected friendship.” Well, they were possibly a lot more than just pals!

    The Friends star’s ex-girlfriend and former assistant Kayti Edwards claimed to The Us Sun on Friday that he was “romantically involved” with Brooke almost two decades ago after they met in an alcoholics anonymous meeting! In fact, Matthew and Brooke were supposedly dating at the same time he was dating Kayti! Whoa! She told the outlet:

    “Brooke dated Matthew in 2006, at around the time I first started hanging out with Matthew. They definitely did not first meet initially in rehab, we all met in AA in 2006. She and I were seeing him at the same time, there was no girlfriend and boyfriend relationship – we just dated. He would take me out on dates and he would take her out on dates. It was kind of like this thing, like ‘Are you going out with Brooke tonight? ​​It was back and forth between her and I but they were definitely romantically involved.”

    What?! Kayti said the relationship between Brooke and Matthew probably lasted about three months:

    “She was like my rival, I knew of her and I’m sure she knew of me. We were hanging out with Matthew, dating him and it wasn’t really a big deal. It was probably a three-month thing because that’s what him and I were. Him and Brooke and me and he never went out publicly and looked romantic, it was always in his house.”

    Of course, Brooke married Charlie two years after they supposedly dated. For years, she and the comedian seemingly were not in contact. Kayti shared:

    “Back in 2010 when I started working for Matthew I even asked about her and if he still talked with Brooke and what he thought about her being with Charlie. He said it didn’t surprise him because that was who she was. She wanted to hook up with an actor with money, so it didn’t surprise him. That’s what she wanted, that lifestyle of being married and having kids with an actor, and I don’t think Matthew was ever going to give that to her.

    Kayti believes the actress and Matthew reconnected sometime after she last spoke to him following the release of his memoir Friends, Lovers, and the Big Terrible Thing in November 2022 because he never told her about it. She explained:

    “At that time he said he didn’t talk to her so they must have reconnected more recently, in the last two years or so I would guess. She was sober when she was dating Matthew in 2006 because he was sober at that time. It’s possible that after Charlie she went off the rails and they reconnected in rehab. I guess I never asked but if they were hanging out I’m pretty sure he would have said ‘Guess who I ran into?’”

    If this is true, is that why the police reportedly wanted to question Brooke? Because they reconnected years after their alleged relationship? It is unknown what the police wanted to ask her about Matthew’s death. Kayti has a theory, though! She claimed the Fools Rush In star had a history of asking people to deliver him drugs:

    “Here’s the bottom line, Matthew was very persuasive. When he was in active addiction he would make out that it wasn’t a big deal. In my mind it was like ‘If it’s not a big deal why don’t you go and get it?’”

    Even she acted as a “courier” for her at times! Kayti recalled:

    “One time he was shooting at Paramount Studios and he sent me to pick up a package for him from an office, it could have been a doctor’s office. I didn’t open it, it was just a box but I had to walk it through the studio with a name tag on and drive to his trailer and was greeted with an envelope of cash for delivering the box. To this day I don’t know what was in the box.”

    With all this in mind, Kayti thinks Brooke allegedly could have “picked something up” for Matthew sometime before his death:

    “Matthew never got caught for possession because he was smart and he had everybody else do his dirty work. I don’t feel for the doctors who gave it to him but I do feel bad if somebody is going to get in trouble for doing him a favor. I don’t know Brooke enough but I know that if she was involved in this it was probably just picking something up for him.”

    Whoa…

    Brooke has not been arrested for anything at this time. However, the LAPD told People this week that the case is “nearing its conclusion” and feels “multiple people” should be charged with crimes in connection to his death. The US Attorney’s Office will make that final decision after getting all the evidence. If all this is true — Is Brooke one of those people? At this time, she has not addressed any of the reports. But Charlie’s lawyer, Gregory J. Pedrick, addressed the situation, saying:

    “I believe Ms. Mueller’s past choices may have put her in a position to provide some incidental, anecdotal background to the authorities investigating Mr. Perry’s death. Nothing more.”

    Wild stuff! Reactions, Perezcious readers? Let us know in the comments below!

    [Image via InTouch Weekly/The Late Show With Stephen Colbert/YouTube, Nikki Nelson/WENN]

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    Perez Hilton

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  • 4 things to know from Elon Musk’s interview with Don Lemon

    4 things to know from Elon Musk’s interview with Don Lemon

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    SAN FRANCISCO — Don Lemon said Wednesday that his partnership with Elon Musk went down in flames, hours after the former CNN anchor conducted an interview last week with the erratic billionaire for the debut episode of his new independent web-based show.

    “Elon publicly encouraged me to join X with a new show, saying I would have his ‘full support,’” Lemon said in a statement, adding that he took Musk at his word that he was “interested in working directly with diverse voices.”

    In an interview with CNN’s Erin Burnett on Wednesday night, Lemon spoke about his exchange with Musk and shared video excerpts from the 90-minute sit-down, in which Lemon asked Musk questions on an array of topics.

    Lemon said he pressed Musk about the rise in hate speech on X since the billionaire took over the social media platform last year, asking him if he believed that he and the company had a responsibility to moderate hateful content.

    “I don’t have to answer questions from reporters, Don,” Musk replied. “The only reason I’m doing this interview is because you’re on the X platform and you asked for it. Otherwise, I would not do this interview.”

    Lemon also asked Musk about a recent meeting he held with former President Donald Trump. CNN previously confirmed the meeting with Musk, one of several Trump held with donors in Palm Beach in recent weeks as he seeks to raise more money for his financially strained campaign.

    “I was at a breakfast at a friend’s place and Donald Trump came by. That’s it,” Musk said, adding that Trump did “most of the talking.”

    Musk said Trump, who is facing more than a half a billion dollars in civil judgments and multiple criminal cases playing out in the courts, did not ask him for money. Musk said he was “not paying his legal bills in any way shape or form.”

    Lemon also brought up Musk’s open use of the drug ketamine, asking the SpaceX founder if he believed it posed a problem for his government security clearance. Musk, Lemon said, answered no because he has a prescription for the drug.

    In his statement on social media, Lemon said the sit-down he conducted with Musk for the first episode of “The Don Lemon Show,” which will be released Monday on social media platforms including X and YouTube, was “respectful and wide ranging” and that “there were no restrictions on the interview that he willingly agreed to.”

    “His commitment to a global town square where all questions can be asked and all ideas can be shared seems not to include questions of him from people like me,” Lemon added.

    Free speech absolutist?

    In a video posted on his social media Wednesday, Lemon took further aim at Musk’s claim to be a “free speech absolutist.”

    “Throughout our conversation, I kept reiterating to him, although it was tense at times, I thought it was good for people to see our exchange,” Lemon said. “But apparently free speech absolutism doesn’t apply when it comes to questions about him from people like me.”

    While the interview is not yet public, a person familiar with the matter said Musk was miffed when Lemon questioned him on his use of the drug ketamine, his government security clearance, and the issue of antisemitism.

    In a statement, X defended Musk’s decision to pull the plug on its agreement with Lemon.

    “The Don Lemon Show is welcome to publish its content on X, without censorship, as we believe in providing a platform for creators to scale their work and connect with new communities,” the company said in a statement. “However, like any enterprise, we reserve the right to make decisions about our business partnerships, and after careful consideration, X decided not to enter into a commercial partnership with the show.”

    Asked by a user on X what led to the decision, Musk attacked Lemon and CNN, which is not involved in Lemon’s new venture.

    “His approach was basically just ‘CNN, but on social media’, which doesn’t work, as evidenced by the fact that CNN is dying,” Musk wrote. “And, instead of it being the real Don Lemon, it was really just [former CNN chief] Jeff Zucker talking through Don, so lacked authenticity.”

    But a spokesperson for Lemon told CNN that the media personality expects Musk to honor the financial terms of the agreement.

    “Don has a deal with X and expects to be paid for it,” the spokesperson said. “If we have to go to court we will.”

    Lemon technically had not inked a contract with X, people familiar with the matter told CNN. But contracts do not necessarily have to be signed to be legally binding, particularly if it is clear each side had arrived at a mutual understanding. And according to the people close to the matter, Lemon’s camp is confident that a deal had effectively been struck, as evidenced by the fact that X had touted the deal in public announcements earlier this year. Moreover, Musk himself appeared to acknowledge that there had been a deal, texting Jay Sures, the UTA power agent who represents Lemon, “contract is canceled,” according to people familiar with the matter.

    Recruited by Musk

    The deal’s implosion comes after Musk urged Lemon to launch a show on his platform, writing last year on X: “It’d be great to have [MSNBC host] Rachel Maddow, Don Lemon & others on the left put their shows on this platform. No exclusivity or legal docs required! You will receive our full support. The digital town square is for all.”

    In another post, Musk directly appealed to Lemon: “Have you considered doing your show on this platform? Maybe worth a try. Audience is much bigger.”

    Musk has claimed to believe in free speech absolutism, but he has repeatedly taken steps to limit the speech of critics. The billionaire has at times suspended journalists from his platform and filed lawsuits against watchdogs for publishing reports critical of X.

    While Musk frequently launches ugly attacks on journalists and traditional news organizations, he has simultaneously elevated conspiracy theories and extremist rhetoric.

    Last year, Musk endorsed an antisemitic conspiracy theory, which resulted in droves of advertisers fleeing X. Only then, days afterward, did Musk publicly express remorse for his actions.

    Lemon was ousted from CNN last year, in a decision that the longtime anchor said left him “stunned.” No specific reason was given by CNN for Lemon’s dismissal, but it came after he was widely criticized for making sexist comments about then-GOP presidential candidate Nikki Haley. Lemon apologized for the remarks at the time, saying, “When I make a mistake, I own it. And I own this one as well.”

    (The-CNN-Wire & 2023 Cable News Network, Inc., a Time Warner Company. All rights reserved.)

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    CNNWire

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  • Paramedics Found Guilty In Death Of Elijah McClain, Who They Injected With An Overdose Of Ketamine

    Paramedics Found Guilty In Death Of Elijah McClain, Who They Injected With An Overdose Of Ketamine

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  • 2 paramedics found guilty in death of Elijah McClain, who they injected with an overdose of ketamine

    2 paramedics found guilty in death of Elijah McClain, who they injected with an overdose of ketamine

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    BRIGHTON, Colo. (AP) — Two Denver-area paramedics were convicted Friday for giving a fatal overdose of the sedative ketamine in the 2019 death of Elijah McClain – a jury verdict that experts said could have a chilling effect on first responders around the country.

    The case over the 23-year-old Black man’s death was the first among several recent criminal prosecutions against medical first responders to reach trial, potentially setting the bar for prosecutors in future cases.

    It also was the last of three trials against police and paramedics charged in the death of McClain, whose case received little attention until protests over the 2020 killing of George Floyd in Minneapolis. An Aurora police officer was convicted of homicide and third degree assault earlier this year while two officers were acquitted.

    The jury found Aurora Fire Rescue paramedics Jeremy Cooper and Peter Cichuniec guilty of criminally negligent homicide following a weekslong trial in state district court. The jury also found Cichuniec guilty on one of two second-degree assault charges. Cooper was found not guilty on the assault charges. They could face years in prison at sentencing.

    McClain’s mother, Sheneen, raised her first in the air and exclaimed, “We did it! We did it! We did it!” while leaving the courthouse with a friend and the president of the Aurora NAACP.

    The outcome could set a precedent going forward for how emergency personnel respond to situations with people in police custody, said University of Miami criminologist Alex Piquero.

    “Imagine if you’re a paramedic,” Piquero said. “They could be hesitant. They could say, ‘I’m not going to do anything’ or ‘I’m going to do less. I don’t want to be found guilty.’”

    The verdict was announced after two days of deliberations. When jurors told the judge Friday afternoon they were stuck on one of the charges, the judge told them to keep trying to reach a verdict. After the verdict was read, deputies prepared to handcuff Cooper as his wife sobbed in the first row.

    Police stopped McClain while he was walking home from a convenience store on Aug. 24, 2019, following a suspicious person complaint. After an officer said McClain reached for an officer’s gun — a claim disputed by prosecutors — another officer put him in a neck hold that rendered him temporarily unconscious. Officers also pinned down McClain before Cooper injected him with an overdose of ketamine. Cichuniec was the senior officer and said it was his decision to use ketamine.

    Prosecutors said the paramedics did not conduct basic medical checks of McClain, such as taking his pulse, before giving him the ketamine. The dose was too much for someone of his size — 140 pounds (64 kilograms), experts testified. Prosecutors say they also did not monitor McClain immediately after giving him the sedative but instead left him lying on the ground, making it harder to breathe.

    McClain’s pleading words captured on police body camera video, “I’m an introvert and I’m different,” struck a chord with protesters and people around the country.

    In a statement released prior to the verdict, McClain’s mother said that everyone present during the police stop of her son displayed a lack of humanity.

    “They can not blame their job training for their indifference to evil or their participation in an evil action,” McClain wrote. “That is completely on them. May all of their souls rot in hell when their time comes.”

    Defense attorneys argued that the paramedics followed their training in giving ketamine to McClain after diagnosing him with “ excited delirium,” a disputed condition some say is unscientific and has been used to justify excessive force.

    The verdicts came after a jury in Washington state cleared three police officers of all criminal charges on Thursday in the 2020 death of Manuel Ellis, a Black man who was shocked, beaten and restrained face-down on a Tacoma sidewalk as he pleaded for breath.

    In the Colorado case, the prosecution said Cooper lied to investigators to try to cover up his actions, telling detectives that McClain was actively resisting when he decided to inject McClain with ketamine, even though the body camera showed McClain lying on the ground unconscious. It also disputed Cooper’s claim that McClain tried to get away from police holding him down — and that he took McClain’s pulse as he bent down to give him the shot of ketamine, which others testified they did not see.

    “He’s trying to cover up the recklessness of his conduct,” Senior Assistant Attorney General Jason Slothouber told jurors in closing statements.

    Cichuniec, who testified along with Cooper this week, said paramedics were trained that they had to work quickly to treat excited delirium with ketamine and said they were told numerous times that it was a safe, effective drug and were not warned about the possibility of it killing anyone.

    Colorado now tells paramedics not to give ketamine to people suspected of having the controversial condition known as excited delirium, which has symptoms including increased strength and has been associated with racial bias against Black men.

    “We were taught that is a safe drug and it will not kill them,” he testified.

    Local authorities in 2019 decided against criminal charges because the coroner’s office could not determine exactly how McClain, a massage therapist, died. Colorado Gov. Jared Polis ordered state Attorney General Phil Weiser’s office to take another look at the case in 2020 and a grand jury indicted the officers and paramedics in 2021.

    The killings of McClain, Floyd and others triggered a wave of legislation that put limits on the use of neck holds in more than two dozen states.

    When the police stopped McClain he was listening to music and wearing a mask that covered most of his face because he had a blood circulation disorder. The police stop quickly became physical after McClain, seemingly caught off guard, asked to be left alone. He had not been accused of committing any crime.

    The officers told investigators that they took McClain down after hearing Officer Randy Roedema say, “He grabbed your gun dude.” Roedema later said Officer Jason Rosenblatt’s gun was the target.

    Prosecutors refuted that McClain ever tried to grab an officer’s gun and no such action is seen in body camera footage.

    Paramedic injected McClain with ketamine as Roedema — and another officer, who was not charged — held him on the ground. McClain went into cardiac arrest en route to the hospital and died three days later.

    Roedema was convicted earlier this month of the least serious charge in a series of charges he could’ve faced, which could lead to a sentence of anywhere from probation to prison time.

    Rosenblatt and officer Nathan Woodyard were acquitted of all charges.

    In the first trials against the police officers, the defense sought to pin the blame for McClain’s death on the paramedics.

    The city of Aurora in 2021 agreed to pay $15 million to settle a lawsuit brought by McClain’s parents.

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  • Matthew Perry died from ‘acute effects of ketamine,’ autopsy finds – National | Globalnews.ca

    Matthew Perry died from ‘acute effects of ketamine,’ autopsy finds – National | Globalnews.ca

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    Matthew Perry died from the acute effects of the anesthetic ketamine, according to the results of an autopsy on the 54-year-old “Friends” actor released Friday.

    The Los Angeles County Department of Medical Examiner said in the autopsy report that Perry also drowned in “the heated end of his pool,” but that it was a secondary factor in his Oct. 28 death, deemed an accident.

    People close to Perry told investigators that he was undergoing ketamine infusion therapy, an experimental treatment used to treat depression and anxiety. But the medical examiner said the levels of ketamine in Perry’s body were in the range used for general anesthesia during surgery, and that his last treatment 1 1/2 weeks earlier wouldn’t explain those levels. The drug is typically metabolized in a matter of hours.

    The report says coronary artery disease and buprenorphine, which is used to treat opioid use disorder, also contributed.

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    Click to play video: 'Matthew Perry, ‘Friends’ star, dead at 54, reports say'


    Matthew Perry, ‘Friends’ star, dead at 54, reports say


    The amount of ketamine detected “would be enough to make him lose consciousness and lose his posture and his ability to keep himself above the water,” said Dr. Andrew Stolbach, a medical toxicologist with Johns Hopkins Medicine who reviewed the autopsy report at the request of The Associated Press.

    “Using sedative drugs in a pool or hot tub, especially when you’re alone, is extremely risky and, sadly, here it’s fatal,” said Stolbach, who noted that both ketamine and buprenorphine can be used safely.

    Perry was declared dead after being found unresponsive at his home in the Pacific Palisades area of Los Angeles. Investigators performed the autopsy the following day.

    The actor had taken drugs in the past but had been “reportedly clean for 19 months,” according to the report.

    Perry had played pickleball earlier in the day, the report says, and his assistant, who lives with him, found him face down in the pool after returning from errands.

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    The assistant told investigators Perry had not been sick, had not made any health complaints, and had not shown evidence of recent alcohol or drug use.

    Postmortem blood tests showed “high levels” of ketamine in his system, which could have raised his blood pressure and heart rate and dulled his impulse to breathe.

    Buprenorphine, commonly used in opioid addiction and found found in therapeutic levels in Perry’s blood, could have contributed to the breathing problem, the autopsy said. It would have been risky to mix the central nervous system depressant with ketamine “due to the additive respiratory effects when present with high levels of ketamine,” according to the autopsy report.


    Click to play video: 'Fans Mourn the Loss of ‘Friends’ Star Matthew Perry'


    Fans Mourn the Loss of ‘Friends’ Star Matthew Perry


    The report said his coronary artery disease would have made him more susceptible to the drugs’ effects.

    Perry was among the biggest television stars of his generation when he played Chandler Bing alongside Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and David Schwimmer for 10 seasons from 1994 to 2004 on NBC’s megahit sitcom “Friends.”

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    His castmates, like many of his friends, family and fans, were stunned by his death, and paid him loving tribute in the weeks that followed.

    Perry was open about discussing his struggles with addiction dating back to his time on “Friends.”

    “I loved everything about the show but I was struggling with my addictions which only added to my sense of shame,” he wrote in his 2022 memoir. “I had a secret and no one could know.”


    Click to play video: '‘Friends’ cast share statement on Matthew Perry’s death: ‘We are a family’'


    ‘Friends’ cast share statement on Matthew Perry’s death: ‘We are a family’


    A woman whose name is redacted in the autopsy report told investigators that Perry had been in good spirits when she spoke to him a few days earlier, but had been taking testosterone shots which she said were making him “angry and mean.” She said he had quit smoking two weeks earlier.

    The woman said he had been receiving the ketamine infusions for his mental health, and that his doctor had been giving them to him less often because he had been feeling well.

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    Ketamine is a powerful anesthetic approved by U.S. health regulators for use during surgery, but in the past decade it has emerged as an experimental treatment for a range of psychiatric and hard-to-treat conditions, including depression, anxiety and chronic pain.

    While not approved by regulators, doctors are free to prescribe drugs for these alternate uses if they think their patients could benefit, and hundreds of clinics across the U.S. offer ketamine infusions and other formulations for various health conditions.

    &copy 2023 The Canadian Press

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  • Matthew Perry died from acute effects of ketamine, officials rule

    Matthew Perry died from acute effects of ketamine, officials rule

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    Matthew Perry died from acute effects of ketamine, a drug sometimes used to treat depression, officials said.

    The ketamine caused cardiovascular overstimulation and respiratory depression, the Los Angeles County medical examiner said. Other contributing factors in the actor’s death included drowning, coronary artery disease and the effects of buprenorphine, a medication used to treat opioid use disorder.

    Perry’s Oct. 28 death was an accident, according to an autopsy.

    The actor was best known for playing the sarcastic and witty Chandler Bing on NBC’s “Friends” for 10 seasons, from 1994 to 2004. In his 2022 memoir, Perry said he began abusing substances at the age of 14 and landed the role on “Friends” a decade later. Fame increased his dependency on alcohol and drugs. At one point, he said in his book, he took nearly five dozen pills a day.

    Following his death at his home in Pacific Palisades, trace amounts of ketamine were found in Perry’s stomach, the medical examiner noted. The level found in his blood was about the same quantity as would be used during general anesthesia.

    According to the report, Perry had been playing pickleball at about 11 that morning, and his live-in assistant last saw him at 1:37 p.m.

    Upon returning to Perry’s home on Blue Sail Drive, the assistant found him floating face-down in his swimming pool. The assistant jumped in, pulled Perry’s head out of the water and called 911.

    Paramedics arrived and moved Perry onto the grass, where he was pronounced dead.

    The report noted that Perry had no other drugs in his system and had been 19 months sober at the time of his death. There was no evidence of illicit drugs or paraphernalia at Perry’s home.

    Perry was undergoing ketamine infusion therapy every other day for a period of time but had reduced that intake more recently, and his last known infusion was a week and a half before his death.

    The medical examiner noted the ketamine could not have been from that session as it typically disappears from the system in detectable amounts within three to four hours.

    The medical examiner also noted that Perry, 54, had diabetes and suffered from chronic obstructive pulmonary disease, which refers to a group of diseases that cause airflow blockage and breathing-related problems. He also smoked two packs of cigarettes a day.

    A coroner’s investigator interviewed a person close to Perry who described him as in “good spirits” and said he had quit smoking two weeks prior to his death and was weaning himself off ketamine.

    A legal medication commonly used medically as an anesthetic, ketamine has been increasingly offered “off label” at private clinics in an effort to treat depression and other mental health disorders, said Dr. David Goodman-Meza, an addiction medicine and infectious disease specialist at UCLA.

    Some people also snort or inject it recreationally to experience euphoric or “dissociative” effects that cause someone to feel separated from their own body, Goodman-Meza said. At very high doses, it can make people feel immobilized and spur hallucinations, an experience called a “K-hole.”

    The drug can complicate breathing and increase demands on the heart. If someone already has coronary artery disease and is taking high doses of ketamine, “that could then speed up your heart, create more demand, but then your arteries don’t have the ability to supply that demand,” the physician explained.

    Tucker Avra, a UCLA medical student who works with people recovering from ketamine addiction, said that people using ketamine can also be at risk of passing out or falling down. “If you’re in water,” he said, there’s “a risk of drowning by basically putting yourself under anesthesia by using it.”

    Avra said those using ketamine should test their drugs for the synthetic opioid fentanyl, have Narcan on hand to reverse an opioid overdose in case the drug is contaminated with opioids, and avoid using the drug alone. He said he hoped the tragedy of Perry’s death might encourage doctors to learn more about the side effects of recreational use.

    In 2006, the National Institute of Mental Health concluded that an intravenous dose of ketamine had rapid antidepressant effects. About 300 clinical trials have been held, and they have broadly found that ketamine is extremely fast-acting compared with traditional antidepressants and can relieve depression for a period that can last days or weeks.

    A prescription version of ketamine called Spravato, given through a nasal spray, was approved in 2019 by the FDA for treatment-resistant depression. The number of ketamine clinics in the U.S. has risen from a few dozen to several hundred in the last few years.

    “Ketamine overdose by itself is exceedingly rare,” said Dr. Siddarth Puri, associate medical director of prevention for the Substance Abuse Prevention and Control division at L.A. County’s public health department.

    In general, much of the overdose concern around ketamine surrounds mixing it with other substances that can also affect breathing or heart rate, such as alcohol or opioids, he said.

    People are also at higher risk of bad outcomes if they have underlying conditions such as high blood pressure or breathing problems, Puri said. In medical settings, Puri said, “your doctor is making sure your heart can manage and respond to ketamine appropriately, your breathing is OK … you’re not having any kind of allergic reaction,” and other medications will not compound its effects.

    Perry described taking ketamine infusions in his memoir, “Friends, Lovers, and the Big Terrible Thing.”

    “It’s used for two reasons: to ease pain and help with depression. Has my name written all over it — they might as well have called it ‘Matty,’” he wrote. “Ketamine felt like a giant exhale. They’d bring me into a room, sit me down, put headphones on me so I could listen to music, blindfold me, and put an IV in.”

    He wrote that he would “disassociate” while listening to music and “often thought that I was dying during that hour.”

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    Richard Winton, Emily Alpert Reyes

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  • Chrissy Teigen Says She ‘Saw’ Late Son Jack During Ketamine Therapy Session – Perez Hilton

    Chrissy Teigen Says She ‘Saw’ Late Son Jack During Ketamine Therapy Session – Perez Hilton

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    It sounds like Chrissy Teigen had a “nice” but emotional birthday this year.

    The cookbook author rang in her 38th year around the sun on Thursday. And the following day, she took to Instagram to share with fans that she celebrated her special day by spending time with her four kids and friends – and doing ketamine therapy. During the session, Chrissy said she “saw” her late son, Jack. Alongside pictures from that day, she wrote:

    “I had a really nice birthday went to to see my friends @flamingo_estate, had a beautiful lunch with friends, then did ketamine therapy and saw space and time and baby jack and some weird penguins and cried and cried and cried. Then laid with my babies, then hot pot, then hung with my best friend”

    Related: Chrissy & John Legend Renewed Their Vows For 10th Wedding Anniversary!

    Wow. You can see the post (below):

    Heartbreaking. We cannot imagine how hard that session must have been. Perezcious readers will recall that Chrissy and John Legend tragically lost their son Jack in 2020 due to partial placenta abruption. She opened up about the devastating experience two years later, saying at Propper Daley‘s “A Day of Unreasonable Conversation” summit “had to make a lot of difficult and heartbreaking decisions” at the time. She continued:

    “It became very clear around halfway through that he would not survive, and that I wouldn’t either without any medical intervention. Let’s just call it what it was: It was an abortion. An abortion to save my life for a baby that had absolutely no chance. And to be honest, I never, ever put that together until, actually, a few months ago.”

    We hope Chrissy still had a good birthday this year. Reactions, Perezcious readers? Let us know in the comments below.

    [Image via The Kelly Clarkson Show/YouTube]

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  • Ketamine for Migraine: One Person’s Journey

    Ketamine for Migraine: One Person’s Journey

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    Nicole Safran was angry. After several years of different migraine treatments, one of her pain doctors suggested that it might be time to try a drug called ketamine. “Absolutely not,” she told her doctor. She knew about the drug’s shady past as a party drug known as “special K” and she didn’t want to be linked to it in any way. 


    But Safran was getting desperate. She had developed chronic migraine after a train accident in 2016 when she was 25. Years later, she was still trying to regain control of her life.


    In retrospect, says Safran, she likely had undiagnosed symptoms of migraine from childhood, most obviously abdominal pain and nausea. But after the accident, which caused a serious concussion, her symptoms increased exponentially. 




    She had throbbing pain in her head, jaw, neck, and sinus area, tingling in the back of her head, light sensitivity, tinnitus, and phantom smells and visual effects (auras), among other symptoms. Doctors diagnosed chronic intractable migraine. “I basically had some level of head pain and migraine symptoms every day,” Safran says. And on many of those days, her symptoms were debilitating. 


    The effects on her work life were immediate. Her managers were confused. She simply wasn’t able to do what she could do before the accident. 


    “I was very close to losing my job.” 


    Her social life took a hit as well. “I’ve lost many friends throughout the process, even though I learned they probably really weren’t friends to begin with. But that’s really challenging when you’re in your mid-20s, living in New York City and your whole world comes crashing down around you and you don’t really know what the future holds.” 


    “People just constantly dismiss you and think, ‘Oh, it’s just a headache,’” Safran says. “No! It’s so much more than that. It is a full-body disease. It impacts every aspect of my life.”


    To make things worse, her response to a laundry list of standard medications and therapies had been patchy at best. She could get some moderate relief some of the time, but nothing seemed to really cut through the constant barrage of migraine symptoms for any length of time. 


    And so in June 2021, after a long discussion with her doctor and some reading about the therapeutic uses of ketamine, she decided to give it a try.

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  • Hong Kong jails first person for possession of CBD products after woman arriving from US caught with drugs – Medical Marijuana Program Connection

    Hong Kong jails first person for possession of CBD products after woman arriving from US caught with drugs – Medical Marijuana Program Connection

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    Hong Kong jails first person for possession of CBD products after woman arriving from US caught with drugs Original Author … Read More

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  • The Future of Treatment

    The Future of Treatment

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    By James Giordano, PhD, as told to Kara Mayer Robinson

    Over the last 20 years, we’ve seen major strides in the treatment options for major depressive disorder.

    We now understand that depression isn’t the same for everyone. The idea is to identify and diagnose what’s happening in a person’s neurochemistry so we can target our treatment in a way that works specifically for them.

    Advances in Evidence-Based Treatment

    Drug therapy has come a long way in recent years. We’ve improved the scope and focus of drug therapy by developing more selective or specialized antidepressants and combining them in new ways, with fewer side effects.

    Drug therapy today may include newer medications like citalopram (Celexa) and escitalopram (Lexapro) as well as existing medications like fluoxetine (Prozac) and sertraline (Zoloft). 

    It tends to work best when combined with psychotherapy, as supported by ample evidence. We now know the most effective and efficient types of therapy appear to be cognitive-behavioral and psychodynamic therapy.

    For people whose depression is resistant to psychotherapy and drug therapy, doctors may use electroconvulsive therapy (ECT). Today’s version of ECT is much more specific, with lower side effects. It’s usually reserved for people who have severe, drug-resistant depression with bipolar characteristics.

    Newer Treatments

    Many new therapies have been introduced that have led to major improvement for patients.

    Ketamine

    A newer therapy involves the drug ketamine, which has been used in the past as an anesthetic and has robust benefits. It’s a relatively new approach. It’s been around for about 5 years.

    Ketamine therapy resets your brain node and network connectivity to reduce, if not abolish, many depressive signs and symptoms. Many patients have longstanding relief, and in some cases, recover.

    Ketamine therapy may involve as little as a single dose. Or it could be multiple doses over a short period of time. But it must be done under medical supervision. While it’s usually outpatient therapy, proper dosing and support of a patient using ketamine is critical.

    It’s not the first drug of choice because it has fairly profound effects on the brain and has to be used with caution. Right now it’s used for severe treatment-resistant depression. But there’s an ongoing discussion that people with severe depression may do well using it earlier in treatment.

    I think you’ll see an increased use of ketamine in the future, particularly for those who don’t get help from other treatments.

    Psychedelics

    There’s building evidence for the use of psychedelic drugs to treat major depression.

    Drugs like psilocybin, commonly known as mushrooms, and LSD (lysergic acid diethylamide) can change the properties in your brain chemistry that are involved in depression.

    Microdoses or millidoses of these drugs can be very effective, either by themselves or when used with antidepressants. They can improve symptoms, behavior, and function. They tend to be fast-acting, but for some people the effects don’t last long.

    Psychedelics are still viewed with relative stigma and they’re a controlled substance. It’s necessary to find the right microdose and schedule for the best effect. Not all clinicians are skilled, comfortable, or willing to provide psychedelic drugs.

    Another drawback is that people may try to self-medicate, which is very difficult. This is a very specific method that requires clinical skill.

    More research is needed. We need medicine-based evidence for the use and value of psychedelics in treating certain types of depression.

    Transcranial Magnetic Stimulation (TMS)

    TMS, which involves passing a very weak magnetic current through your skull, is interesting. It works like a dimmer switch to change the electrical activity of your brain and reduce signs and symptoms of depression.

    There’s very promising research that repetitive TMS can be very effective in treating certain forms of treatment-resistant depression. It’s very easy to do, can be tailored to each patient’s needs, and often has a rapid and durable response. It can be used by itself or combined with psychotherapy or drug treatment.

    But while the effects of TMS are robust, they may taper over time. It may require multiple sessions, and you have to find a clinician who’s trained and skilled to administer TMS.

    Deep Brain Stimulation (DBS)

    Deep brain stimulation is a new, emerging treatment that involves implanting electrodes to target specific areas of the brain. It can be adjusted for each individual patient to most effectively control their symptoms and signs of depression.

    DBS was first tried in 2005. Since then, the science has advanced considerably with the help of the BRAIN Initiative, an NIH program aimed at revolutionizing our understanding of the human brain. Now we have a better understanding of how to target the brain more precisely, which may lead to better results. More research will help even more.

    DBS appears to reset the network activities of the brain. Over time, the brain activity involved in depression may be turned off, which means patients stay in remission. There’s evidence to suggest DBS has long-lasting effects.

    An interesting effect we’ve seen with some patients is how significantly it changes their outlook. Some people appear more outgoing and ebullient, with a newfound vigor and even changing interests. It’s hard to tell if these changes are a side effect of DBS or if it’s the result of feeling the burden of depression lifted. It’s very interesting.

    A downside of DBS is that it’s neurosurgery, so there’s the risk of infection and hemorrhage. It’s rare, but there’s also a risk of misplacement, or electrode drift.

    Other cons include side effects and cost. Insurance companies don’t uniformly cover DBS. As the technology gets better, there will be a need for maintenance and upkeep that may be costly.

    I believe DBS is the future. When it works, it really works.

    On the Horizon

    The emerging technology is moving toward minimal or noninvasive DBS.

    There’s cutting-edge technology involving nonsurgical implantation of electrodes. A program at DARPA, an agency that supports the BRAIN Initiative, is looking at small transmitters and stimulators that can be delivered into the bloodstream, inhaled, or even swallowed, then guided to the brain.

    Other groups are looking at minimally invasive approaches that can be done in a doctor’s office. All it requires is a very small hole in your scalp, where doctors insert fluid electrodes, then guide them to the brain electromagnetically. When they get to the brain, they harden.

    I believe this is the future. It may be ready in some form in 5-10 years.

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  • Advances in Treatment for Major Depressive Disorder

    Advances in Treatment for Major Depressive Disorder

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    Major depressive disorder is the most widespread mood disorder in the world. Also called clinical depression, or just depression, it’s when you have symptoms of low mood or hopelessness for at least 2 weeks. Scientists still don’t know what causes it. But they know that treating it is complex and that people who have it need more ways to feel better faster.

    For about half a century, scientists have put a lot of effort into improving medications that target a small set of neurotransmitters. Those are chemicals in the brain — serotonin, norepinephrine, and dopamine in particular — that affect how your nerve cells talk to each other, which then affects your mood.

    Most people respond to standard antidepressants. But at least 30% of people who try two different kinds of these drugs continue to have symptoms of depression. That’s called treatment-resistant depression.

    So, over the past 2 decades, scientists have changed how they think about treatment for major depressive disorder as their understanding of the brain biology behind depression has changed.

    The biggest change is that medication research has gone past only targeting certain neurotransmitters, says Gerard Sanacora, MD, PhD, director of the Yale Depression Research Program in New Haven, CT. “We’ve opened up a whole new vista of potential targets for new drugs.” 

    New Medications and Faster Results

    There’s a long-held idea that depression takes weeks or months to resolve. But new fast-acting treatments have “changed what we think is possible in the field,” Sanacora says.   

    In 2019, the FDA approved brexanolone (Zulresso). It’s the first drug specifically for postpartum depression, which is a type of major depression. Experts aren’t exactly sure how it works. But it’s a human-made version of a steroid your body makes naturally. It affects your GABA receptors, which help regulate mood.

    Brexanolone isn’t as easy to take as other antidepressants. You get it through a vein in your arm at a health care facility over the course of 60 hours. But it can work quickly. Your depression symptoms might start to lift by the end of your treatment.

    Another breakthrough drug came out that same year.     

    Esketamine is a prescription nasal spray. The low-dose psychedelic drug boosts the activity of glutamate in parts of your brain related to mood. Glutamate’s job is to excite cells in the brain and nervous system. Esketamine can trigger new connections in your brain too. You may start to see improvements in your depression within hours or days of using it, Sanacora says.

    Esketamine offers lifesaving hope for people with suicidal thoughts and relief for people with treatment-resistant depression. But used alone, symptom relief may only last a couple of weeks. That’s why experts agree you should take rapid-onset drugs alongside traditional treatments.

    As for those with mild or moderate depression, Sanacora still first suggests cognitive behavioral therapy, followed by conventional antidepressants also known as selective serotonin reuptake inhibitors (SSRIs). Doctors need more information on the safety and long-term effects of newer treatments for depression.

    “Over the past 20 years, we’ve had a transformative change in the way we treat depression,” Sanacora says. “But we still have to smooth it out to understand for which patients these treatments are best and when.”

    Improvements in Brain Stimulation

    Medications aren’t the only treatment for depression. Electroconvulsive therapy has been around for more than 70 years. It remains one of the most effective ways to manage major depressive disorder, especially if you don’t respond to other treatments. While it isn’t new, scientists have fine-tuned the procedure over the past decades.

    Today, electroconvulsive therapy uses less energy than it did in the past. The goal is to give you the same benefits but with less negative impact on your memory and thinking skills. “That’s been a huge improvement,” says Susan Conroy, MD, PhD, a psychiatrist and neuroscientist at Indiana University School of Medicine.

    Conroy also uses transcranial magnetic stimulation to treat depression, which has fewer side effects than electroconvulsive therapy. It works by sending magnetic pulses around your skull.

    Brain tissue translates these signals into electrical energy, Conroy says, which changes the way areas of your brain talk to each other. “By changing that circuitry, we think that’s how transcranial magnetic stimulation gets people better from depression.”

    These and other forms of brain stimulation aren’t right for everyone. But tell your doctor if other treatments don’t help and your depression keeps you from doing daily activities, you aren’t eating, and you have constant suicidal thoughts.

    “These are all signs your treatment needs to be escalated and pretty quickly,” Conroy says.

    Future Treatment

    Lots of other promising treatments for depression are on the horizon. Deep brain stimulation is one. In this treatment, a surgeon implants electrodes in your brain. These nodes send painless zaps that alter the electrical activity that’s causing your symptoms.

    You can think of this treatment kind of like a pacemaker for your mood. While it’s not approved for the general public, it might be soon. “Technology is advancing really quickly,” Conroy says.

    Researchers are also studying a drug called SAGE-217. Sanacora says there’s interest in how it might help prevent a serious relapse in people with a history of depression. The idea is that you’d take it as soon as your symptoms come back. “But you don’t wait until the symptoms are full-blown,” he says.

    There’s also a lot of buzz around drugs like psilocybin. Studies show these “magic mushrooms” can ease depression about as fast as ketamine — what esketamine is made from — with effects that may last longer. But when it comes to psychedelics, Sanacora says, “We need a lot more research before we can say anything with confidence.”

    In his 25 years in the field, Sanacora says he’s never seen such excitement around treatments for depression. But that doesn’t mean researchers have all the answers or that major depressive disorder has a cure.

    Still, you can take steps now to ease depression or guard against a relapse. That might include medication, different kinds of talk therapy, regular exercise, a good social life, and a healthy sleep routine. You should be doing “all the things we know you can do to protect yourself as much as possible,” Sanacora says.

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