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Tag: inflammation

  • Should We Fast for IBS? | NutritionFacts.org

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    More than half of irritable bowel syndrome (IBS) sufferers appear to have a form of atypical food allergy.

    A chronic gastrointestinal disorder, irritable bowel syndrome affects about one in ten people. You may have heard about low-FODMAP diets, but they don’t appear to work any better than the standard advice to avoid things like coffee or spicy and fatty foods. In fact, you can hardly tell which is which, as shown below and at 0:27 in my video Friday Favorites: Fasting for Irritable Bowel Syndrome.

    Most IBS patients, however, do seem to react to specific foods, such as eggs, wheat, dairy, or soy sauce, but when they’re tested with skin prick tests for typical food allergies, they may come up negative. We want to know what happens inside their gut when they eat those things, though, not what happens on their skin. Enter confocal laser endomicroscopy.

    You can snake a microscope down the throat, into the gut, and watch in real-time as the gut wall becomes inflamed and leaky after foods are dripped in. Isn’t that fascinating? You can actually see cracks forming within minutes, as shown below and at 1:03 in my video. This had never been tested on a large group of IBS patients, though, until now.

    Using this new technology, researchers found that more than half of IBS sufferers have this kind of reaction to various foods—“an atypical food allergy” that flies under the radar of traditional allergy tests. As you can see below and at 1:28 in my video, when you exclude those foods from the diet, there is a significant alleviation of symptoms.

    However, outside a research setting, there’s no way to know which foods are the culprit without trying an exclusion diet, and there’s no greater exclusion diet than excluding everything. A 25-year-old woman had complained of abdominal pain, bloating, and diarrhea for a year, and drugs didn’t seem to help. But, after fasting for ten days, her symptoms improved considerably and appeared to stay that way at least 18 months later. It wasn’t just subjective improvement either. Biopsies were taken that showed the inflammation had gone down, her bowel irritability was measured directly, and expanding balloons and electrodes were inserted in her rectum to measure changes in her sensitivity to pressure and electrical stimulation. Fasting seemed to reboot her gut in a way, but just because it worked for her doesn’t mean it works for others. Case reports are most useful when they inspire researchers to put them to the test.

    “Despite research efforts to develop a cure for IBS, medical treatment for this condition is still unsatisfactory.” We can try to suppress the symptoms with drugs, but what do we do when even that doesn’t work? In a study of 84 IBS patients, 58 of whom failed basic treatment (consisting of pharmacotherapy and brief psychotherapy), 36 of the 58 who were still suffering underwent ten days of fasting, whereas the other 22 stuck with the basic treatment. The findings? Those in the fasting group experienced significant improvements in abdominal pain, bloating, diarrhea, loss of appetite, nausea, anxiety, and interference with life in general, which were significantly better than those of the control group. The researchers concluded that fasting therapy “could be useful for treating moderate to severe patients with IBS.”

    Unfortunately, patient allocation was neither blinded nor randomized in the study, so the comparison to the control group doesn’t mean much. They were also given vitamins B1 and C via IV, which seems typical of Japanese fasting trials, even though one would not expect vitamin-deficiency syndromes—beriberi or scurvy—to present within just ten days of fasting. The study participants were also isolated; might that make the psychotherapy work better? It’s hard to tease out just the fasting effects.

    Psychotherapy alone can provide lasting benefits. Researchers randomized 101 outpatients with irritable bowel syndrome to medical treatment or medical treatment with three months of psychotherapy. After three months, the psychotherapy group did better, and the difference was even more pronounced a year later, a year after the psychotherapy ended. Better at three months, and even better at 15 months, as you can see here and at 3:58 in my video.

    Psychological approaches appear to work about as well as antidepressant drugs for IBS, but the placebo response for IBS is on the order of 40%, whether psychological interventions, drugs, or alternative medicine approaches. So, doing essentially nothing—taking a sugar pill—improves symptoms 40% of the time. In that case, I figure one might as well choose a therapy that’s cheap, safe, simple, and free of side effects, which extended fasting is most certainly not. But, if all else fails, it may be worth exploring fasting under close physician supervision.

    All my fasting videos are available in a digital download here.

    Check the videos on the topic that are already on the site here. 

    For more on IBS, see related posts below. 

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    Michael Greger M.D. FACLM

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  • This Weightlifting Mistake Can Get In The Way Of Your Progress (& A Quick Fix)

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    Trainers weigh in on how to prevent burnout and anxiety in the gym.

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  • 4 Ways To Build A Brain Bank & Prevent Cognitive Decline

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    Cognitive decline and even just normal brain changes associated with aging threaten to impact our memories and way of thinking—two things we very much want to hold on to as long as possible. But some people are more resilient to signs of memory loss than others, even when there’s physiological evidence of memory loss. 

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  • Is Your Skin Keeping You Up At Night? The Eczema–Sleep Connection

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    If you’ve ever dealt with eczema, you know it’s more than just dry, itchy skin—it’s a full-body experience that can affect everything from your mood to your energy levels. But here’s something you might not realize: that persistent itch could be quietly sabotaging your sleep.

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  • Oolong Tea Benefits & How It Compares To Black Tea

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    Though oolong tea is low in nutrients, it’s packed with plant compounds that have antioxidant and anti-inflammatory effects in the body. It’s a concentrated source of polyphenols, including theaflavins3, theasinensins, thearubigins4, epigallocatechin (EGC), and epigallocatechin gallate (EGCG), all of which have antioxidant and anti-inflammatory properties. 

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  • 8 Easy Ways To Protect Eye Health & Prevent Vision Loss, From An Optometrist

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    How to eat, exercise, and sleep your way to better eye health.

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  • 3 Smoothie Add-Ins For A Healthier Gut & Inflammatory Response

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    A smoothie a day is arguably one of the easiest ways to pack in loads of nutrients—many of which you can customize tailored to your health goals. Want more protein? Toss some powder in your smoothie. Looking for immune support? Load up your blend with citrus. 

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  • Percussive Therapy: What It Is, Benefits & More

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    Massage guns are popular, and if you’ve tried one, you know why. These handheld devices are designed to ease discomfort, soothe tension and tightness, and promote faster muscle recovery. And they do all of that through percussive massage therapy. (Picture a sleek mini jackhammer that you can use on tight, tense muscles, and you get a general idea.)

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  • 4 Powerful Ways Adaptogens Benefit Dogs and Cats (and the #1 Herb for Them!) | Animal Wellness Magazine

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    Adaptogens benefit dogs and cats in many ways. Here’s a look at four of the most important advantages and why it’s smart to include KSM-66 Ashwagandha in their diet!

    Adaptogens are natural substances like herbs that help the body resist stress. They’re becoming increasingly popular among dog and cat parents, especially as science begins to learn about additional ways they naturally support pet health. One of the most powerful adaptogens is an ancient herb called ashwagandha. The most clinically studied ashwagandha—KSM-66 Ashwagandha—is the only one clinically proven for pets. Let’s look at four key ways adaptogens benefit dogs and cats and why food, treats, and supplements should feature KSM-66 Ashwagandha!

    1. Adaptogens Regulate Cortisol and Reduce Stress

    One of the key benefits of adaptogens is their ability to regulate the stress hormone cortisol. High cortisol levels can contribute to anxiety, digestive issues, and immune dysfunction. By balancing cortisol and other hormones, adaptogenic herbs such as ashwagandha help calm the nervous system and improve resilience to stress.

    2. Adaptogenic Herbs Promote Healing and Restoration

    Adaptogenic herbs help the body heal and repair itself. For example, ashwagandha supports tissue regeneration, promotes wound healing, and modulates inflammation, thereby speeding recovery from illness or injury.

    3. They Help the Body Resist Oxidative Stress

    Oxidative stress from free radicals contributes to aging, inflammation, and chronic disease. Adaptogens like ashwagandha are rich in antioxidants that neutralize free radicals and protect cells from damage, supporting long-term health and possibly helping to slow the progression of degenerative conditions.

    4. Adaptogens Normalize Cellular Function

    Adaptogens help the body on a cellular level, promoting cellular energy production and helping maintain homeostasis. That’s the body’s ability to maintain a stable internal environment with respect to temperature, pH levels, and fluid balance. Homeostasis is necessary for all vital functions, and imbalances can cause severe illness or worse. The balancing effect of adaptogens like ashwagandha helps all animals, especially ones with complex or chronic conditions.

    Adaptogens Benefit Dogs and Cats, and KSM-66 Ashwagandha Is a Proven Choice!

    Ashwagandha is a potent adaptogenic herb that promotes overall health and wellness in companion animals. It helps reduce stress, promote healing and restoration, combat oxidative stress, and normalize cellular function. KSM-66 Ashwagandha has 46 certifications for safety and efficacy and is clinically proven for pets to help manage inflammation and stress, support gut health, and promote healthy aging. It has a neutral taste that dogs and cats don’t mind, so it can be included in a variety of food, treats, and supplements.

    Learn more about how adaptogens benefit dogs and cats, find out more about sustainable KSM-66 Ashwagandha, and discover pet products that feature it!


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    Animal Wellness is North America’s top natural health and lifestyle magazine for dogs and cats, with a readership of over one million every year. AW features articles by some of the most renowned experts in the pet industry, with topics ranging from diet and health related issues, to articles on training, fitness and emotional well being.

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    Animal Wellness

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  • Coffee Can Lower Type 2 Diabetes Risk, According To Research

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    Type 2 diabetes, which affects around 1 in 10 people in America, is a chronic disease marked by insulin resistance. Insulin is a hormone that regulates blood sugar, so people with Type 2 diabetes may have high blood sugar levels, which can lead to heart disease, vision loss, and kidney disease. Diabetes is also linked to high inflammation levels

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  • Should You Take Statins?  | NutritionFacts.org

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    How can you calculate your own personal heart disease risk to help you determine if you should start on a cholesterol-lowering statin drug?

    The muscle-related side effects from cholesterol-lowering statins “are often severe enough for patients to stop taking the drug. Of course, these side effects could be coincidental or psychosomatic and have nothing to do with the drug,” given that many clinical trials show such side effects are rare. “It is also possible that previous clinical trials”—funded by the drug companies themselves—“under-recorded the side effects of statins.” The bottom line is that there’s an urgent need to establish the true incidence of statin side effects.

    “What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug?” That’s the title of a journal article that reports that, even in trials funded by Big Pharma, “only a small minority of symptoms reported on statins are genuinely due to the statins,” and those taking statins are significantly more likely to develop type 2 diabetes than those randomized to placebo sugar pills. Why? We’re still not exactly sure, but statins may have the double-whammy effect of impairing insulin secretion from the pancreas while also diminishing insulin’s effectiveness by increasing insulin resistance.

    Even short-term use of statins may “approximately double the odds of developing diabetes and diabetic complications.” As shown below and at 1:49 in my video Who Should Take Statins?, fewer people develop diabetes and diabetic complications off statins over a period of about five years than those who do develop diabetes while on statins. “Of more concern, this increased risk persisted for at least 5 years after statin use stopped.”

    “In view of the overwhelming benefit of statins in the reduction of cardiovascular events,” the number one killer of men and women, any increase in risk of diabetes, our seventh leading cause of death, would be outweighed by any cardiovascular benefits, right? That’s a false dichotomy. We don’t have to choose between heart disease and diabetes. We can treat the cause of both with the same diet and lifestyle changes. The diet that can not only stop heart disease, but also reverse it, is the same one that can reverse type 2 diabetes. But what if, for whatever reason, you refuse to change your diet and lifestyle? In that case, what are the risks and benefits of starting statins? Don’t expect to get the full scoop from your doctor, as most seemed clueless about statins’ causal link with diabetes, so only a small fraction even bring it up with their patients.

    “Overall, in patients for whom statin treatment is recommended by current guidelines, the benefits greatly outweigh the risks.” But that’s for you to decide. Before we quantify exactly what the risks and benefits are, what exactly are the recommendations of current guidelines?

    How should you decide if a statin is right for you? “If you have a history of heart disease or stroke, taking a statin medication is recommended, without considering your cholesterol levels.” Period. Full stop. No discussion needed. “If you do not yet have any known cardiovascular disease,” then the decision should be based on calculating your own personal risk. If you know your cholesterol and blood pressure numbers, it’s easy to do that online with the American College of Cardiology risk estimator or the Framingham risk profiler.

    My favorite is the American College of Cardiology’s estimator because it gives you your current ten-year risk and also your lifetime risk. So, for a person with a 5.8 percent risk of having a heart attack or stroke within the next decade, if they don’t clean up their act, that lifetime risk jumps to 46 percent, nearly a flip of the coin. If they improved their cholesterol and blood pressure, though, they could reduce that risk by more than tenfold, down to 3.9 percent, as shown below and at 4:11 in my video.

    Since the statin decision is based on your ten-year risk, what do you do with that number? As you can see here and at 4:48 in my video, under the current guidelines, if your ten-year risk is under 5 percent, then, unless there are extenuating circumstances, you should just stick to diet, exercise, and smoking cessation to bring down your numbers. In contrast, if your ten-year risk hits 20 percent, then the recommendation is to add a statin drug on top of making lifestyle modifications. Unless there are risk-enhancing factors, the tendency is to stick with lifestyle changes if risk is less than 7.5 percent and to move towards adding drugs if above 7.5 percent.

    Risk-enhancing factors that your doctor should take into account when helping you make the decision include a bad family history, really high LDL cholesterol, metabolic syndrome, chronic kidney or inflammatory conditions, or persistently high triglycerides, C-reactive protein, or LP(a). You can see the whole list here and at 4:54 in my video.

    If you’re still uncertain, guidelines suggest you consider getting a coronary artery calcium (CAC) score, but even though the radiation exposure from that test is relatively low these days, the U.S. Preventive Services Task Force has explicitly concluded that the current evidence is insufficient to conclude that the benefits outweigh the harms.

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    Michael Greger M.D. FACLM

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  • This Lowers Signs Of Inflammation After Menopause, Study Finds

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    And about 41% of all people have insufficient levels of it.

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  • Can’t Sleep? Your Skin May Have Something To Do With It

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    For itchy skin conditions, identifying your triggers (which differ for everyone) is key. From there, keep your skin barrier strong and healthy with moisturizing, lipid-rich ingredients—think ceramides, squalane, fatty acids, etc. Galaria also recommends investing in a humidifier, since a dry environment can damage the moisture barrier and lead to itchiness and irritation.

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  • Plastic Particles Are Acting Like Sponges For Heavy Metals

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    In this study,1 researchers used waste plastics like soda bottles, candy boxes, and takeout containers to create nanoplastics in a lab setting. They then exposed these particles to heavy metals, including lead, cadmium, zinc, cobalt, and manganese, to see what would happen. 

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  • An Unexpected Way To Ease Inflammation In The Gut & Support Digestion

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    Already take probiotics? Add this to your routine.

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  • Managing Aggression in Dogs? Try Ashwagandha for Stress and Anxiety Relief | Animal Wellness Magazine

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    Managing aggression in dogs requires a comprehensive approach, and ashwagandha should be included to reduce aggressive behavior caused by pain, stress, or anxiety.

    Aggression in dogs is often misunderstood, but it’s never about a dog being bad. More often, it’s a response to pain, stress, or anxiety. These underlying issues can trigger behaviors like growling, snapping, and avoidance. While addressing behavioral issues is essential, natural supplements like ashwagandha can play a supportive role in managing aggression in dogs. Ashwagandha, particularly clinically proven KSM-66 Ashwagandha, helps manage cortisol levels, reduce inflammation, and promote calm. When used as part of a holistic approach, it can support dogs struggling with stress- or pain-related aggression, helping them feel more balanced, secure, and happy.

    When to Use Ashwagandha for Managing Aggression in Dogs

    Any dog can be aggressive, which can include growling, snapping, avoiding contact, and changes in body language. But aggression doesn’t happen because a dog is bad. Rather, it’s often a symptom of a deeper problem, such as pain or anxiety, which can cause irritability, defensiveness, and reactivity. Ashwagandha can be an effective tool for managing aggression caused by stress or anxiety because this adaptogenic herb naturally:

    • Helps with stress
    • Reduces inflammation
    • Provides relief from pain
    • Supports restorative sleep
    • Promotes a calm mood

    Since aggression is a behavioral issue, addressing it requires a multifaceted approach that includes pain/stress management along with training and socialization.

    Common Causes of Pain and Stress for Dogs

    Despite best efforts to keep companion animals happy and healthy, there are numerous conditions or experiences that can cause them pain and stress. Things that can lead to aggressive behavior include:

    • Arthritis or joint disease
    • Dental problems
    • Skin infections
    • Hot spots
    • Ear infections
    • Gastrointestinal upset
    • Neurological conditions

    Trust KSM-66 Ashwagandha for Managing Aggression in Dogs Related to Stress and Anxiety

    When you need a proven solution, you need KSM-66 Ashwagandha! It’s the safest and only clinically proven ashwagandha for pets, and it’s the only ashwagandha with carefully controlled levels of withanolides, one of the therapeutic compounds. KSM-66 Ashwagandha has been shown to reduce inflammation and stress, support gut health, and promote healthy aging. As an anti-inflammatory, adaptogenic herb, ashwagandha helps manage cortisol, other hormones, and neurotransmitters, so it’s beneficial for managing aggression in dogs when it’s related to pain or stress.

    Learn more about sustainable, all-natural KSM-66 Ashwagandha and find pet products that feature it!


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    Animal Wellness is North America’s top natural health and lifestyle magazine for dogs and cats, with a readership of over one million every year. AW features articles by some of the most renowned experts in the pet industry, with topics ranging from diet and health related issues, to articles on training, fitness and emotional well being.

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    Animal Wellness

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  • Are Carboxymethylcellulose, Polysorbate 80, and Other Emulsifiers Safe?  | NutritionFacts.org

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    Emulsifiers are the most widely used food additives. What are they doing to our gut microbiome?

    When grocery shopping these days, unless you’re sticking to the produce aisle, “it is nearly impossible to avoid processed foods, particularly in the consumption of a typical Western diet,” which is characterized by insufficient plant foods, too much meat, dairy, and eggs, and a lot of processed junk, “along with increased exposure to additives due to their use in processed foods.”

    The artificial sweetener sucralose, for example, which is sold as Splenda, “irrefutably disrupts the gut microbiome at doses relevant to human use” and “induces glucose intolerance.” In other words, it can make our blood sugars worse instead of better. It’s relatively easy to avoid artificial sweeteners, but “it may be much more difficult to avoid ingestion of emulsifiers…because they are commonly added to a wide variety of foods within the modern Western diet.” In fact, “emulsifiers are the most widely used additives,” and “most processed foods contain one or more emulsifiers that allow such foods to maintain desired textures and avoid separation into distinct parts (e.g, oil and water layers).” We now consume emulsifiers by the megaton every year, thanks to a multibillion-dollar industry, as you can see below and at 1:03 in my video Are Emulsifiers Like Carboxymethylcellulose and Polysorbate 80 Safe?.

    Emulsifiers are commonly found in fatty dressings, breads and other baked goods, mayonnaise and other fatty spreads, candy, and beverages. “Like all authorized food additives, emulsifiers have been evaluated by risk assessors, who consider them safe. However, there are growing concerns among scientists about their possible harmful effects on our intestinal barriers and microbiota,” in terms of causing a leaky gut. As well, they could possibly “increase the absorption of several environmental toxins, including endocrine disruptors and carcinogens” present in the food.

    We know that the consumption of ultra-processed foods may contribute to weight gain. Healthier, longer-lived populations not only have low meat intake and high plant intake, but they also eat minimally processed foods and “have far less chronic diseases, obesity rates, and live longer disease-free.” Based on a number of preclinical studies, it may be that the emulsifiers found in processed foods are playing a role, but who cares if “emulsifiers make rats gain weight”? When we read that “emulsifiers can cause striking changes in the microbiota,” they aren’t talking about the microbiota of humans.

    Often, mice are used to study the impact on the microbiome, but “only a few percent of the bacterial genes are shared between mice and humans.” Even the gut flora of different strains of mice can be considerably different from each other, so if we can’t even extrapolate from one type of mouse to another, how are we supposed to translate results from mice to humans? “Remarkably, there has been little study of the potential harmful effects of ingested…emulsifiers in humans.”

    Take lecithin, for example, which is “perhaps best known as a key component of egg yolks.” Lecithin was found to be worse than polysorbate 80 in terms of allowing bacteria to leak through the gut wall into the bloodstream. However, it’s yet to be determined whether lecithin consumption in humans causes the same problem. “There is certainly a paucity in the data of human trials with the effects of emulsifiers in processed foods,” but we at least have data on human tissue, cells, and gut flora.

    A study was titled: “Dietary emulsifiers directly alter the human microbiota composition and gene expression ex vivo potentiating intestinal inflammation.” Ex vivo means outside the body. Researchers inoculated an artificial gut with fresh human feces until a stable culture was established, then added carboxymethylcellulose (CMC) or polysorbate 80 (P80), resulting in boosts in proinflammatory potential starting within one day with the carboxymethylcellulose and within the first week with polysorbate 80, as you can see below and at 3:39 in my video.

    “This approach revealed that both P80 and CMC acted directly upon human microbiota to increase its proinflammatory potential…” When researchers then tested the effect of these emulsifiers on the protective mucus layer in petri dish cultures of human gut lining cells, they found that they can partially disrupt the protective layer. As you can see below and at 4:00 in my video, the green staining is the mucus. Both emulsifiers cut down the levels.

    However, this study and the last both used emulsifier concentrations that were far in excess of what people might typically get day-to-day. 

    “Translocation of Crohn’s disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers” is probably the study that raised the greatest potential concern. The researchers surgically obtained cells, as well as actual intestinal wall tissue, and found that polysorbate 80 could double the invasion of E. coli through the intestinal lining tissue, as shown here and at 4:27 in my video.

    In contrast, adding fiber—in this case, fiber from plantains—could seal up the gut wall tissue twice as tightly, as seen below and at 4:33.

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    Michael Greger M.D. FACLM

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  • The Functional Lab Testing Revolution

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    What if the very hormone designed to help you survive is actually the reason you’re struggling to thrive?

    My mother relentlessly saved and sacrificed so that she could enjoy her life in retirement. But two years into retirement, she was diagnosed with early onset Alzheimer’s.

    Here’s what I’ve learned since becoming a Functional Diagnostic Nutrition Practitioner: she didn’t just “get” Alzheimer’s two years after retirement. It was building and building for years before that. She was making it worse with lifestyle choices: the over-exercising that women in their 40s and 50s often do, eating trans fats during the low-fat craze of the 80s and 90s.

    Had I known what I know now, her outcome might have been different.

    This is why I’m passionate about functional health. This is why thousands of practitioners are learning to identify and address the root causes of dysfunction before they become disease. If we can reach people in that gray space (when things are out of balance but before they become diagnosable conditions), we can change their trajectory. We can save lives.

    As functional health practitioners, we see it every day: clients who’ve tried everything, followed every protocol, cleaned up their diet, and taken all the right supplements, yet they’re still stuck in that frustrating place of “I’m okay, but I’m not great.”

    The missing piece? Understanding cortisol and its profound impact on every system in the body.

    If you’ve ever wondered why some clients get amazing results while others plateau, or why you yourself might be experiencing symptoms that doctors dismiss as “normal aging,” this deep dive into cortisol will change everything.

    What Is Wellness, Really?

    Before we dive into cortisol, let’s get clear on what we’re actually working toward. At FDN, we don’t believe in “fine” or “okay.” We believe in abundant vitality.

    Picture this as a spectrum:

    The Right Side (The Medical Model): Symptoms → Sickness → Disease → Death

    The Middle (Neutral Health): No symptoms, but no energy either. This is the “I’m fine, I guess” zone where most people live.

    The Left Side (True Wellness): High energy, optimal function, metabolic fire, abundant vitality, joy for life.

    Here’s the thing: neutral health equals a neutral life. When you’re operating from “I’m okay, I don’t have any complaints,” you’re not building empires, writing books, raising joyful kids, or showing up as your best self in relationships.

    Good health, abundant vitality, is your birthright. It’s not just for the lucky few.

    The Body’s Incredible Healing Power (And What’s Limiting It)

    Your body is a self-healing machine. You know this because when you get a cut, it heals. When you break a bone, it mends. When you catch a cold, you recover.

    But this healing ability isn’t infinite. If it were, we’d never age or die.

    So what’s the difference between what your body can heal and what it can’t?

    It’s a savings versus spending problem.

    Think of your body as having a bank account called “Vital Reserve.” This is your innate intelligence: your body’s natural ability to function at 100% and fix imbalances before they become problems.

    Where do you spend this precious currency? On your environment.

    This has always been the case. Our paleolithic ancestors spent their Vital Reserve on not knowing if food would be available, dealing with harsh weather, avoiding predators, and navigating tribal conflicts.

    Today? We spend it on mental-emotional stress, environmental toxins, and poor lifestyle habits that are constantly draining our account.

    The main spender of Vital Reserve is stress.

    The Modern Stress Problem: It’s Not What You Think

    When most people think of stress, they picture this: work deadlines, traffic, relationship conflicts, financial pressure. And yes, these mental-emotional stressors are huge.

    But there are two other categories most people completely miss:

    Physical Stressors:

    • Sitting too long
    • Blue light exposure from screens
    • Too much coffee
    • Not exercising enough (or exercising too much)
    • Needing wine to fall asleep
    • Poor sleep quality

    Environmental Stressors:

    • Depleted soils
    • EMF exposure
    • Chemicals in food, water, and air
    • Toxins our paleolithic ancestors never encountered

    Plus, there’s the existential stress of modern life: What’s my purpose? How do I make my life meaningful when I’ll likely be forgotten in 100 years?

    All of these are constantly withdrawing from your Vital Reserve account.

    how to test cortisol levels naturally

    Meet Cortisol: Your Body’s “Energy on Credit” System

    Cortisol is your primary stress hormone, and it’s actually designed to help you survive. When your environment throws stressors at you, cortisol says, “We need to put internal spending on hold and take all available resources to deal with this external threat.”

    Cortisol breaks the body down for quick energy. We call this “catabolic.”

    Why would your body have a mechanism for breaking itself down? Because sometimes you need energy RIGHT NOW. When your boss says, “This project is actually due in 30 minutes,” you can’t drive to the store, buy food, cook it, eat it, digest it, and then produce energy. You need quick fuel immediately.

    So cortisol reaches for easy-to-break-down tissues like cartilage, tendons, connective tissue, and muscle, converting them to blood sugar.

    Here’s the kicker: Cortisol is also a natural painkiller and anti-inflammatory. It masks the damage it’s doing, which is why it makes you feel amazing in the moment: clear thinking, quick reactions, pain-free movement.

    Think of cortisol as your body’s credit card. You’re borrowing energy now and promising to pay it back later through rest, recovery, and healing.

    When “Energy on Credit” Becomes a Problem

    Throughout history, humans dealt with stress that was intense but occasional and short-lived. A wild animal attack, a natural disaster, a tribal conflict: these were serious but temporary.

    Take a moment to think about this: Does this describe the stress in your life?

    For most of us, stress is intense, constant, and never-ending. We wake up stressed, work stressed, drive home stressed, and lie in bed stressed about tomorrow’s stress.

    This creates what we call “catabolic debt”: you’re constantly running up charges on your cortisol credit card without ever paying it back.

    Chronic stress is not within our biological design.

    Consider this: Anthropological studies show paleolithic humans worked only 15-20 hours per week. How many of you work only 15-20 hours per week? (And remember, “work” includes housework, childcare, and all the other responsibilities that don’t stop when you leave the office.)

    They lived in close communities with cooperative resource sharing and had each other’s backs. Think about your own life: Do you know your neighbors? If you do, would they really have your back if things got serious?

    Most of us are duplicating resources instead of sharing them. We’re all figuring out our own childcare, making our own meals, maintaining our own everything. There’s no interdependence, no shared load.

    The cost of modern life is enormous:

    • 70-80% of doctor visits are for stress-related illnesses
    • People with high anxiety are 4-5 times more likely to die from heart attack or stroke
    • Stress contributes to 50% of all illnesses
    functional medicine approach to high cortisol

    The Stress Response Curve: Your Roadmap to Understanding Where You Are

    This is where it gets really interesting. Understanding this curve will change how you see your health (and your clients’ health) forever.

    We all start in the green zone: Homeostasis. When you experience occasional stressors, cortisol and adrenaline spike, you handle the situation, then return to baseline to rest and repair.

    But when stress becomes chronic, you move into the orange zone: Acute Stress. You’re constantly producing cortisol and adrenaline, never returning to homeostasis.

    Here’s the thing: on your way up this curve, you feel AMAZING. Remember when you could pull all-nighters and still ace exams? When you could eat junk food without consequences? When you had laser focus for 12-16 hours straight?

    That’s the acute phase. You’re running on cortisol, and it feels like superpowers.

    Then you hit Peak Production. Your body says, “We’ve put way too much on the cortisol credit card. We have to cut back.”

    Now you fall into the Compensatory Phase. Your cortisol numbers might look normal to a doctor, but the distribution is all wrong. Maybe you have too much in the morning and crash by afternoon, or you spike at night and can’t sleep.

    Plus, you have a relativity problem. You’re used to feeling like Superman from the acute phase, so normal cortisol levels feel terrible by comparison.

    Continue down this path, and you reach the Exhaustive Phase. Like a phone on low battery mode, everything still works but at 30% capacity and not for long. You’re devoting everything to just getting through the day.

    The Hidden Cost: What Happens to Your Body’s Core Systems

    At FDN, we focus on six foundational systems that chronic stress systematically shuts down. We call them the H-I-D-D-E-N systems, and understanding what happens to each one under chronic stress is crucial for practitioners:

    H – Hormones DHEA is your anabolic hormone: the one responsible for building you back up after cortisol breaks you down. This is how you pay off your cortisol credit card. But when stress is constant, DHEA steps back and says, “I’ll come back when it’s safe to focus internally, but right now we need to keep spending on the environment.” DHEA becomes chronically low, which means your healing potential becomes chronically low.

    Then sex hormones get the message: “We don’t have enough resources to fund fertility right now.” Sex hormones plummet, taking motivation and joy for life with them. This is when you get to that neutral state where you’re thinking, “I have dreams I want to pursue, but it’s just too much effort. I’ll just watch Netflix instead.”

    I – Immune Your immune system is expensive to run. Under chronic stress, it says, “I cost a ton of money, so I’m going to operate at 30% capacity and not for very long.” Now you’re getting sick often, it takes forever to heal, you can’t shake that cough, and if anyone around you is sick, you know you’re going down.

    D – Digestion Digestion costs a lot of energy to function properly. When you’re spending everything on stress, digestion goes into low-power mode. Now you’re only digesting at 30% capacity. Even if you’re eating the cleanest diet in the world, you can’t use it. You’re not getting the building blocks to repair or the nutrients your body needs to power metabolic functions at full capacity.

    D – Detoxification Detoxification is another huge system that’s expensive to run. When your body’s bank account is overdrawn from cortisol debt, detox says, “I don’t have enough money to find these toxins, bind them up, and effectively remove them. So I’ll put them in storage instead.” Your body shoves toxins into fat cells, brain tissue, and bones, creating a toxic backlog that makes you feel slow, gives you acne, throws off digestion, and impairs hormone production.

    E – Energy Production Your mitochondria can’t function optimally when all resources are diverted to stress response. This leads to that “tired but wired” feeling where you’re exhausted but can’t actually rest.

    N – Nervous System Sleep, mood, and cognitive function all suffer. This is where we see the brain fog, insomnia, anxiety, and depression that so many people struggle with.

    The fundamental principle of FDN: These systems don’t operate in isolation. You can’t just say, “Oh, you have classic hormone symptoms, so let’s run a hormone test.” You miss immunity, digestion, detoxification: all the other systems contributing to what we call “Metabolic Chaos.”

    This is why the “take this supplement for that symptom” approach rarely works long-term. You’re not dealing with isolated problems: you’re dealing with systemic dysfunction where multiple systems are compromised simultaneously.

    Real-Life Case Studies: The Stress Curve in Action

    Let’s look at three real clients to see how this plays out. As FDN practitioners, we use what we call “clinical correlation,” which means we never look at lab numbers in isolation. We always consider how someone feels alongside their test results.

    Case Study 1: Adam – The Acute Phase Crash

    Profile: 35-year-old male, broker at a mid-size investment firm, former athlete still crushing CrossFit workouts

    Symptoms: Weight gain, trouble concentrating, loss of muscle mass despite rigorous workouts, headaches 

    Doctor’s Assessment: “Your results are unremarkable. This is normal aging.”

    Lab Results:

    • Cortisol sum: 9 (acute phase)
    • Four-point pattern: Way too high in morning, drops low at noon, crashes severely in afternoon, bounces back up at night
    • DHEA: 2 (low end of normal range)
    • Clinical correlation: Catabolic debt despite “normal” DHEA

    The Reality: How do we know Adam isn’t on the left side of the stress curve going up into acute phase? His symptoms tell us everything. If he were on the way up, he’d feel amazing and wouldn’t be in our office. Instead, he’s on the right side coming down from peak production.

    His cortisol pattern explains everything: sky-high morning cortisol makes him feel wired and anxious, the afternoon crash leaves him unable to concentrate (not ideal for an investment broker), and the nighttime spike disrupts his sleep.

    Even though his DHEA looks “normal,” when we compare it to his cortisol level of 9, he’s clearly catabolic dominant. He’s breaking down faster than he’s building up, which explains why his intense CrossFit sessions aren’t building muscle: they’re just adding more stress to an already overloaded system.

    Case Study 2: Caitlyn – The Compensatory Struggle

    Profile: 48-year-old court stenographer, recently divorced 

    Symptoms: Insomnia, fatigue, joint pain 

    Doctor’s Assessment: “Your results are fine. Everything’s in normal range.”

    Lab Results:

    • Cortisol sum: Compensatory phase (appears “normal” to doctors)
    • Four-point pattern: Way too low in morning, slightly higher at noon, drops severely in afternoon, spikes at night
    • DHEA: Low
    • Clinical correlation: Cortisol dominant, catabolic debt

    The Reality: Caitlyn’s cortisol sum looks normal, but the distribution is completely dysfunctional. She can barely drag herself out of bed in the morning, crashes hard in the afternoon (imagine trying to accurately record legal proceedings when your cortisol is plummeting), and lies awake at night because her cortisol spikes just when it should be lowest.

    She also has a relativity problem. When she was in the acute phase, she felt like Superman. Now that she’s in compensatory with “normal” cortisol levels, she feels terrible by comparison. Her DHEA is low, confirming she’s still in catabolic debt despite the lower cortisol numbers.

    Case Study 3: Maggie – The Exhaustive Phase Crisis

    Profile: 43-year-old chef at a popular five-star restaurant, diagnosed with hypothyroid 

    Symptoms: Weight gain in hips and belly, trouble keeping up at work, depression, irregular menstrual cycle 

    Lifestyle: Working 60+ hours per week, consistently sleeping only 5 hours per night 

    Medical Status: Seeing a counselor, considering antidepressant medication

    Lab Results:

    • Cortisol sum: 3.1 (exhaustive phase)
    • Four-point pattern: Way too low in morning, drops low at noon, slight bounce in afternoon, drops again at night
    • DHEA: Very low
    • Clinical correlation: Still catabolic dominant despite low cortisol

    The Reality: Maggie’s body is operating like a phone on low battery mode: everything still works, but at 30% capacity and not for long. Her thyroid has downregulated because there’s literally not enough energy in the system to maintain normal function.

    The depression isn’t just psychological: it’s physiological. Her body can’t afford to fund optimal brain function. Even though her cortisol is very low and her DHEA is very low, she’s still cortisol dominant and in catabolic debt.

    This is why understanding the stress curve is so crucial. Three people, three different phases, three different approaches needed.

    functional lab testing for health coaches

    The Path Forward: Why Understanding Cortisol Changes Everything

    Here’s why this matters for you as a health practitioner:

    1. It explains why some clients plateau. If you’re not addressing the stress component, you’ll hit a ceiling on healing no matter how perfect the diet or supplement protocol.

    2. It validates your clients’ experiences. When someone says, “I used to be able to handle so much more,” or “I don’t feel like myself anymore,” you now understand the physiology behind it.

    3. It gives you a roadmap for intervention. Different phases require different approaches. Someone in the acute phase needs different support than someone in the exhaustive phase.

    4. It highlights the importance of comprehensive testing. A single cortisol measurement tells you almost nothing. You need the full pattern plus clinical correlation.

    The FDN Approach: Test, Don’t Guess

    At FDN, we don’t just talk about stress: we measure it. We use what we call “clinical correlation,” which means we never look at lab numbers in isolation. We always consider how someone feels alongside their test results.

    We look at:

    • Four-point cortisol patterns throughout the day (not just a single measurement)
    • DHEA levels and the cortisol-to-DHEA ratio
    • How stress is affecting all the H-I-D-D-E-N systems
    • The complete picture of metabolic chaos
    • Progress tracking with tools like the Metabolic Chaos Scorecard

    Then we address it systematically through our DRESS protocol:

    D – Diet: Personalized nutrition based on lab findings, not generic “healthy eating” advice 

    R – Rest: Sleep optimization and recovery strategies tailored to your stress phase 

    E – Exercise: Right-sized movement for your current capacity (over-exercise is just as harmful as under-exercise) 

    S – Stress Reduction: Targeted techniques for your specific stressors: mental/emotional, physical, environmental, and lifestyle factors 

    S – Supplementation: Targeted support based on actual lab results, not guesswork

    This isn’t about generic protocols. It’s about understanding exactly where someone is on the stress curve and what their body needs to heal.

    Key Takeaways for Health Practitioners

    Cortisol isn’t the enemy. A lot of people talk about cortisol as if it’s the villain—commercials make it sound like cortisol just makes you “old and fat.” That’s not what cortisol does. Cortisol is a vital hormone for navigating stress. The problem is chronic stress disrupting its natural rhythm.

    Understanding the stress curve is diagnostic gold. It explains why clients feel the way they do and gives you a framework for intervention. Different phases require different approaches.

    Clinical correlation is everything. You can’t just look at lab numbers in isolation. A cortisol sum of 5 might be “normal” to a doctor, but if your client feels terrible and the distribution is dysregulated, that tells you the real story.

    You can’t ignore stress and expect lasting results. No matter how perfect your diet protocol or how targeted your supplements, chronic stress will cap healing potential. There’s a ceiling you’ll never break through if you don’t address the stress component.

    The body’s systems are interconnected. You can’t just “fix hormones” without addressing how stress is affecting immunity, digestion, detoxification, and all the other H-I-D-D-E-N systems. This is why comprehensive testing and systematic protocols are crucial.

    Metabolic Chaos requires a systematic approach. When multiple systems are compromised simultaneously, you need a framework like DRESS that addresses all aspects of healing, not just isolated symptoms.

    Your Next Steps

    If you’re ready to master functional lab testing and learn how to identify and address cortisol dysregulation in your practice, FDN provides the training, community, and ongoing support you need.

    Because here’s the truth: your clients deserve more than “fine.” They deserve abundant vitality. And you deserve the confidence that comes from knowing exactly how to help them achieve it.

    When you understand cortisol (really understand it), you hold the key to unlocking transformation for every client who walks through your door.

    Ready to become the practitioner who always knows what to do next?

    The answer lies in data-driven functional health. The answer lies in understanding that robust health isn’t just about the absence of symptoms: it’s about the presence of vitality.

    And it starts with the hormone you can’t ignore: cortisol.

    Want to learn more about becoming a Functional Diagnostic Nutrition Practitioner? 

    Discover how our comprehensive training program gives you the tools to master cortisol testing, interpretation, and protocols that get results. Because when you know how to test, you never have to guess. View an indepth case study here. 

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    Elizabeth Gaines

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  • 9 Amazing Ways All-Natural KSM-66 Ashwagandha Supports Pet Health! | Animal Wellness Magazine

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    Here are 9 powerful ways all-natural KSM-66 Ashwagandha can change our dog and cat’s health for the better, just by adding it to their diet.

    Ashwagandha is an ancient adaptogenic herb with many health benefits for modern dogs and cats. Its wide-ranging benefits make it a powerful addition to any dog’s or cat’s daily diet. But what exactly is it about this adaptogenic herb that makes it so effective? All-natural KSM-66 Ashwagandha is a high-quality, root-only extract known for its high potency and safety. It contains a unique blend of therapeutic compounds that support the body in a variety of ways, from easing stress and enhancing sleep to reducing inflammation and supporting cognitive health. Let’s explore how this premium form of ashwagandha can benefit our companion animals’ well-being and why it deserves a place in their daily routine.

    1. Ashwagandha Reduces Anxiety

    Ashwagandha is a natural anxiolytic, meaning it reduces anxiety and promotes emotional balance. It works by lowering cortisol levels and calming the nervous system, without the drowsiness or side effects of pharmaceutical sedatives. It’s particularly helpful for animals dealing with:

    • General stress
    • Separation or travel anxiety
    • Noise phobias
    • Stress-related behaviors
    • Aggression related to anxiety

    2. KSM-66 Ashwagandha Is Proven to Promote Calm

    Unlike generic extracts, KSM-66 Ashwagandha has been extensively studied in dogs, cats, and even horses. These studies show it can reduce behavioral signs of stress—such as digestive upset, destructive behavior, or withdrawal—making it a reliable option for promoting a calm and balanced temperament in companion animals.

    3. The Herb Has Anti-Inflammatory Properties

    Chronic inflammation underlies many common health problems in dogs and cats, from joint problems to skin conditions. Ashwagandha’s natural anti-inflammatory properties help reduce pain, swelling, and discomfort, making it a useful tool for managing:

    • Arthritis
    • Mobility issues
    • Allergies
    • Chronic disease
    • And more

    4. It Helps Modulate the Immune System

    Ashwagandha’s anti-inflammatory properties also help to keep the immune system in balance, preventing both underactive and overactive immune responses. This helps the body fight infections, manage autoimmune conditions, and relieve allergies.

    5. It Has the Power to Enhance Cognition

    As dogs and cats age, cognitive decline can impact memory, learning, and behavior, just like with humans. Ashwagandha acts as a nootropic, meaning it supports memory, brain health, and mental clarity. Further, its antioxidant and anti-inflammatory effects help older animals and seniors stay sharp and responsive as they age.

    6. Ashwagandha Acts as a Sleep Aid

    Because of its calming effects, ashwagandha also acts as a natural sleep aid. Deep, restorative sleep is essential for healing, immune function, and mood regulation. This makes all-natural KSM-66 Ashwagandha especially helpful for seniors, animals recovering from illness, or those with high levels of stress or anxiety.

    7. Promoting Better Sleep Means Less Fatigue

    Low energy, lethargy, or exercise intolerance could be signs of chronic fatigue or stress. Ashwagandha improves resilience and vitality by supporting healthy energy levels, mitochondrial function, and stress recovery.

    8. It Supports the HPA Axis

    The hypothalamic-pituitary-adrenal (HPA) axis controls how the body responds to stress. Ashwagandha helps balance cortisol and other hormones, promoting healthy adrenal function, stable mood, and healthy energy level.

    9. It Supports Muscle Maintenance and Growth

    Lastly, KSM-66 Ashwagandha has anabolic properties that support muscle strength and recovery. This makes it ideal for active animals, seniors, or those recovering from injury or illness. It can even help reduce muscle wasting in dogs or cats with chronic disease.

    Look for KSM-66 Ashwagandha in Supplements, Treats, and Food!

    Ashwagandha is a versatile, natural supplement for dogs and cats, and KSM-66 Ashwagandha is the safest and only clinically proven one for pets. Whether your dog or cat needs help with anxiety, inflammation, sleep, or aging gracefully, KSM-66 Ashwagandha’s premium, root-only extract is a powerful ingredient to look for in treats, food, and supplements. The levels of therapeutic compounds are carefully controlled to ensure companion animals get all the benefits without any side effects. And the company’s dedication to quality and sustainability guarantee their ashwagandha is good for people, companion animals, and the planet.

    Learn more about the pet health benefits of all-natural KSM-66 Ashwagandha and find pet products that feature this ancient herb with modern benefits!


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    Animal Wellness is North America’s top natural health and lifestyle magazine for dogs and cats, with a readership of over one million every year. AW features articles by some of the most renowned experts in the pet industry, with topics ranging from diet and health related issues, to articles on training, fitness and emotional well being.

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    Animal Wellness

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