ReportWire

Tag: infectious diseases

  • US shift on Venezuelan migrants fuels anxiety in Mexico

    US shift on Venezuelan migrants fuels anxiety in Mexico

    TIJUANA, Mexico — Jose Maria Garcia Lara got a call asking if his shelter had room for a dozen Venezuelan migrants who were among the first expelled to Mexico under an expanded U.S. policy that denies rights to seek asylum.

    “We can’t take anyone, no one will fit,” he answered, standing amid rows of tents in what looks like a small warehouse. He had 260 migrants on the floor, about 80 over capacity and the most since opening the shelter in 2012.

    The phone call Thursday illustrates how the Biden administration’s expansion of asylum restrictions to Venezuelans poses a potentially enormous challenge to already overstretched Mexican shelters.

    The U.S. agreed to let up to 24,000 Venezuelans apply online to fly directly to the U.S. for temporary stays but said it will also start returning to Mexico any who cross illegally — a number that topped 25,000 in August alone.

    The U.S. expelled Venezuelans to Tijuana and four other Mexican border cities since Wednesday, said Jeremy MacGillivray, deputy director of the United Nations’ International Organization for Migration in Mexico. The others are Nogales, Ciudad Juarez, Piedras Negras and Matamoros.

    Casa del Migrante in Matamoros admitted at least 120 Venezuelans from Brownsville on Thursday, said the Rev. Francisco Gallardo, the shelter director. On Friday, the Mexican government was offering free bus rides to Mexico City.

    Venezuelans have suddenly become the second-largest nationality at the U.S. border after Mexicans, a tough challenge for President Joe Biden. Nearly four out of five who were stopped by U.S. authorities in August entered in or near Eagle Pass, Texas, across from Piedras Negras, a Mexican city of about 150,000 people with scarce shelter space.

    “We are on the verge of collapse,” said Edgar Rodriguez Izquierdo, a lawyer at Casa del Migrante in Piedras Negras, which feeds 500 people daily and is converting a school to a shelter for 150 people.

    Tijuana, where Garcia Lara runs the Juventud 2000 shelter, is the largest city on Mexico’s border and likely has the most space. The city says 26 shelters, which are running near or at capacity, can accommodate about 4,500 migrants combined.

    Tijuana’s largest shelter, Embajadores de Jesus, is hosting 1,400 migrants on bunk beds and floor mats, while a group affiliated with University of California, San Diego, is building a towering annex for thousands more.

    Embajadores de Jesus is growing at a blistering pace at the bottom of a canyon where roosters roam freely and shanties made of plywood and aluminum sheets line dirt roads and cracked pavement that easily flood when it rains. A cinderblock building with a kitchen and dining area is nearing completion, while migrants shovel dirt for a soccer field.

    Gustavo Banda, like other shelter directors in Tijuana, doesn’t know what to expect from the U.S. shift on Venezuela, reflecting an air of uncertainty along the Mexican border. Tijuana was blindsided by a surge in Haitian arrivals in 2016, a giant caravan from Central America in 2018 and the implementation in 2019 of a now-defunct policy to make asylum-seekers wait in Mexico for hearings in U.S. immigration court.

    “Nobody really knows what’s going to happen until they start sending people back,” Banda said Thursday as families with young children prepared for sleep.

    Mexico’s Foreign Affairs Ministry said it would temporarily admit “some” Venezuelans who are expelled from the U.S. under a public health order known as Title 42, without indicating a numerical cap. The U.S. has expelled migrants more than 2.3 million times since Title 42 took effect in March 2020, denying them a chance at asylum on grounds of preventing the spread of COVID-19.

    A Mexican official said Mexico’s capacity to take back Venezuelans hinges on shelter space and success of the U.S. offer of temporary stays for up to 24,000 Venezuelans. The official was not authorized to discuss the matter publicly and spoke condition of anonymity.

    Until now, Mexico has only accepted returns from Guatemala, Honduras or El Salvador, in addition to Mexico. As a result, Mexican shelters have been filled with migrants from those countries, along with Haitians.

    Venezuelans, like those of other nationalities including Cuba and Nicaragua, have generally been released in the United States to pursue immigration cases. Strained diplomatic relations have made it nearly impossible for the Biden administration to return them to Venezuela.

    Blas Nuñez-Neto, a top U.S. Homeland Security Department official, didn’t answer directly when asked by reporters Thursday how many Venezuelans are likely to be expelled to Mexico, saying only that he expects fewer will try to cross the border.

    Homeland Security said Venezuelans who cross the border by land after Wednesday’s announcement will be expelled. Edward Pimentel was among the migrants who said they were returned despite being in U.S. custody before the policy was announced.

    “The truth is that our dream is the American dream, we wanted to go to the United States,” Pimentel said outside a Tijuana convenience store.

    In Matamoros, hundreds of Venezuelans protested, saying they entered the U.S. before the policy took effect. Gregori Josue Segovia, 22, said he was processed by U.S. authorities Monday in El Paso, Texas, and was moved around before ending up in Matamoros.

    “We were on three buses and they told us nothing, but we thought everything was normal when we realized were on the (international) bridge” to be returned to Mexico, he said Friday.

    About 7 million Venezuelans have fled their homeland in recent years but had largely avoided the U.S. The U.S. offers a relatively strong economy and slim chances of being returned to Venezuela, suddenly making it more attractive.

    For Venezuelans in Mexico, their best hope may be a U.S. exemption from Title 42 for people deemed particularly vulnerable.

    In Tijuana, it appears more migrants are getting such exemptions from the U.S. Homeland Security Department. The U.S. has been allowing about 150 migrants a day at a border crossing to San Diego, said Enrique Lucero, Tijuana’s director of migration affairs.

    Many are chosen by advocacy groups from Tijuana shelters — causing some migrants to move there not for a place to stay but for a better shot at being selected to enter the U.S., said Lucero.

    Embajadores de Jesus keeps a notebook with names of migrants hoping to qualify for a Title 42 exemption. Banda, a pastor and shelter director, said they wait about three months to enter the U.S.

    Venezuelans who were in Mexico before Wednesday may also apply for one of the 24,000 temporary slots that the U.S. is making available, similar to an effort launched in April for up to 100,000 Ukrainians fleeing Russia’s invasion. They must have a financial sponsor in the U.S. and pay for their flights.

    Mexico welcomed statements from U.S. officials that the temporarily relief offered to Ukrainians and now Venezuelans may expand to other nationalities.

    Orlando Sanchez slept in a bus station in Mexico City with hundreds of other Venezuelans waiting to receive money from family. He said he didn’t have enough for a flight.

    Naile Luna, a Venezuelan who was on her way to Ciudad Juarez, across the border from El Paso, said she hoped being eight months pregnant would spare her being expelled to Mexico. She said she knew nothing about the new policy.

    ———

    Verza reported from Mexico City. Associated Press writer Gisela Salomon in Miami and videographer Jordi Lebrija in Tijuana contributed to this report.

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  • Viral infections are less frequent but more severe in people with Down syndrome due to oscillating immune response

    Viral infections are less frequent but more severe in people with Down syndrome due to oscillating immune response

    Newswise — Individuals with Down syndrome have less-frequent viral infections, but when present, these infections lead to more severe disease. New findings publishing on October 14 in the journal Immunity show that this is caused by increased expression of an antiviral cytokine type I interferon (IFN-I), which is partially coded for by chromosome 21. Elevated IFN-I levels lead to hyperactivity of the immune response initially, but the body overcorrects for this to reduce inflammation, leading to increased vulnerability later in the viral attack.

    “Usually too much inflammation means autoimmune disease, and immune suppression usually means susceptibility to infections,” says senior study author Dusan Bogunovic of the Icahn School of Medicine at Mount Sinai. “What is unusual is that individuals with Down syndrome are both inflamed and immunosuppressed, a paradox of sorts. Here, we discovered how this is possible.”

    Down syndrome is typically caused by triplication of chromosome 21. This syndrome affects multiple organ systems, causing a mixed clinical presentation that includes intellectual disability, developmental delays, congenital heart and gastrointestinal abnormalities, and Alzheimer’s disease in older individuals.

    Recently, it has become clear that atypical antiviral responses are another important feature of Down syndrome. Increased rates of hospitalization of people with Down syndrome have been documented for influenza A virus, respiratory syncytial virus, and severe acute respiratory syndrome due to coronavirus (SARS-CoV-2) infections.

    While people with Down syndrome show clear signs of immune disturbance, it has yet to be elucidated how a supernumerary chromosome 21 leads to dysregulation of viral defenses. To address this knowledge gap, the researchers compared fibroblasts and white blood cells derived from individuals with and without Down syndrome, at both the mRNA and protein levels. They focused on the potent antiviral cytokine IFN-I receptor subunits IFNAR1 and IFNAR2, which are located on chromosome 21.

    The researchers found that increased IFNAR2 expression was sufficient for the hypersensitivity to IFN-I observed in Down syndrome, independent of trisomy 21. But subsequently, the hyper-active IFN-I signaling cascade triggered excessive negative feedback via a protein called USP18, which is a potent IFNAR negative regulator. This process, in turn, suppressed further responses to IFN-I and antiviral responses. Taken together, the findings unveil oscillations of hyper- and hypo-responses to IFN-I in Down syndrome, predisposing to both lower incidence of viral disease and increased infection-related morbidity and mortality.

    “We have a lot more to do to completely understand the complexities of the immune system in Down syndrome,” says first author Louise Malle of the Icahn School of Medicine at Mount Sinai. “We have here, in part, explained the susceptibility to severe viral disease, but this is only the tip of the iceberg.”

    ###

    Cell Press

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  • Study finds Paxlovid can interact badly with some heart medications, and White House renews COVID emergency through Jan. 11

    Study finds Paxlovid can interact badly with some heart medications, and White House renews COVID emergency through Jan. 11

    A new study has found that the COVID antiviral Paxlovid can interact badly with certain heart medications, raising concerns for patients with cardiovascular risk who test positive.

    The study was published in the Journal of the American College of Cardiology and found the reaction involved such medications as blood thinners and statins. As patients who are hospitalized with COVID are at elevated risk of heart problems, they are likely to be described Paxlovid, which was developed by Pfizer
    PFE,
    -0.45%
    .

     “Co-administration of NMVr (Paxlovid) with medications commonly used to manage cardiovascular conditions can potentially cause significant drug-drug interactions and may lead to severe adverse effects,” the authors wrote. “It is crucial to be aware of such interactions and take appropriate measures to avoid them.”

    The news comes just days after the White House made a renewed push to encourage Americans above the age of 50 to take Paxlovid or use monoclonal antibodies if they test positive and are at risk of developing severe disease.

    White House coordinator Dr. Ashish Jha told the New York Times that greater use of the medicine could reduce the average daily death count to about 50 a day from close to 400 currently.

    “I think almost everybody benefits from Paxlovid,” Jha said. “For some people, the benefit is tiny. For others, the benefit is massive.” 

    Yet a smaller share of 80-year-olds with COVID in the U.S. is taking it than 45-year-olds, Jha said, citing data said he has seen.

    On Thursday, the White House extended its COVID pubic health emergency through Jan. 11 as it prepares for an expected rise in cases in the colder months, the Associated Press reported.

    The public health emergency, first declared in January 2020 and renewed every 90 days since, has dramatically changed how health services are delivered.

    The declaration enabled the emergency authorization of COVID vaccines, as well as free testing and treatments. It expanded Medicaid coverage to millions of people, many of whom will risk losing that coverage once the emergency ends. It temporarily opened up telehealth access for Medicare recipients, enabling doctors to collect the same rates for those visits and encouraging health networks to adopt telehealth technology.

    Since the beginning of this year, Republicans have pressed the administration to end the public health emergency.

    President Joe Biden, meanwhile, has urged Congress to provide billions more in aid to pay for vaccines and testing. Amid Republican opposition to that request, the federal government ceased sending free COVID tests in the mail last month, saying it had run out of funds for that effort.

    Separately, the head of the World Health Organization urged countries to continue to surveil, monitor and track COVID and to ensure poorer countries get access to vaccines, diagnostics and treatments, reiterating that the pandemic is not yet over.

    Tedros Adhanom Ghebreyesus said most countries no longer have measures in place to limit the spread of the virus, even though cases are rising again in places including Europe.

    “Most countries have reduced surveillance drastically, while testing and sequencing rates are also much lower,” Tedros said in opening remarks at the IHR Emergency Committee on COVID-19 Pandemic on Thursday.

    “This,” said the WHO leader, “is blinding us to the evolution of the virus and the impact of current and future variants.”

    U.S. known cases of COVID are continuing to ease and now stand at their lowest level since late April, although the true tally is likely higher given how many people overall are testing at home, where the data are not being collected.

    The daily average for new cases stood at 38,530 on Thursday, according to a New York Times tracker, down 19% from two weeks ago. Cases are rising in six states, namely Nevada, New Mexico, Kansas, Maine, Wisconsin and Vermont, and are flat in Wyoming. They are falling everywhere else.

    The daily average for hospitalizations was down 7% at 26,665, while the daily average for deaths is down 7% to 377. 

    The new bivalent vaccine might be the first step in developing annual Covid shots, which could follow a similar process to the one used to update flu vaccines every year. Here’s what that process looks like, and why applying it to Covid could be challenging. Illustration: Ryan Trefes

    Coronavirus Update: MarketWatch’s daily roundup has been curating and reporting all the latest developments every weekday since the coronavirus pandemic began

    Other COVID-19 news you should know about:

    • Federal Health Minister Karl Lauterbach has urged German states to reintroduce face-mask requirements for indoor spaces due to high COVID cases numbers, the Local.de reported. Lauterbach was launching his ministry’s new COVID campaign on Friday. “The direction we are heading in is not a good one,” he said at a press conference in Berlin, adding it’s better to take smaller measures now than be forced into drastic ones later.

    • Health officials in Washington and Oregon said Thursday that a fall and winter COVID surge is likely headed to the Pacific Northwest after months of relatively low case levels, the AP reported. King County (Wash.) Health Officer Dr. Jeff Duchin said during a news briefing that virus trends in Europe show a concerning picture of what the U.S. could soon see, the Seattle Times reported.

    Two banners unfurled from a highway overpass in Beijing condemned Chinese President Xi Jinping and his strict Covid policies, in a rare display of defiance. The protest took place days before the expected extension of the leader’s tenure.

    • Kevin Spacey’s trial on sexual-misconduct allegations will continue without a lawyer who tested positive for COVID on Thursday, Yahoo News reported. The “American Beauty” and “House of Cards” star is on trial in Manhattan federal court facing allegations in a $40 million civil lawsuit that he preyed upon actor Anthony Rapp in 1986 when Rapp was 14 and Spacey was 26. Jennifer Keller’s diagnosis comes after she spent about five hours cross-examining Rapp on the witness stand over two days — a few feet away from the jury box without wearing a mask.

    • A man who presents himself as an Orthodox Christian monk and an attorney with whom he lived fraudulently obtained $3.5 million in federal pandemic relief funds for nonprofit religious organizations and related businesses they controlled, and spent some of it to fund a “lavish lifestyle,” federal prosecutors said Thursday. Brian Andrew Bushell, 47, and Tracey M.A. Stockton, 64, are charged with conspiracy to commit wire fraud and unlawful monetary transactions, the U.S. attorney’s office in Boston said in a statement, as reported by the AP.

    Here’s what the numbers say:

    The global tally of confirmed cases of COVID-19 topped 623.9 million on Monday, while the death toll rose above 6.56 million, according to data aggregated by Johns Hopkins University.

    The U.S. leads the world with 96.9 million cases and 1,064,821 fatalities.

    The Centers for Disease Control and Prevention’s tracker shows that 226.2 million people living in the U.S., equal to 68.1% of the total population, are fully vaccinated, meaning they have had their primary shots. Just 110.8 million have had a booster, equal to 49% of the vaccinated population, and 25.6 million of those who are eligible for a second booster have had one, equal to 39% of those who received a first booster.

    Some 14.8 million people have had a shot of the new bivalent booster that targets the new omicron subvariants.

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  • Regina Spektor postpones tour due to ‘bad case’ of Covid-19 | CNN

    Regina Spektor postpones tour due to ‘bad case’ of Covid-19 | CNN



    CNN
     — 

    Regina Spektor has put her national tour on hold after coming down with a “bad case” of Covid-19, the singer announced on Instagram.

    The Grammy-nominated singer-songwriter, 42, wrote that she caught the virus “after being so careful and miraculously avoiding it for over 2.5 years,” and went on to apologize to ticket holders.

    “I have gone from feeling bad, to worse, to terrible. I’ve lost my voice. I am a bit delirious from fever, so in advance I apologize if this note isn’t too coherent,” she wrote in a note posted to her official Instagram. “We will reschedule the shows for when the theaters are able to have me back.”

    Her now-postponed tour was going to hit cities in New York, New Jersey, DC, Georgia, North Carolina, Tennessee and California.

    She performed the opening night of the tour, set to run through the end of this month, in Chicago earlier this week.

    “I just want to add that my heart is with all the people who have suffered from the different iterations of this virus over this long while,” Spektor added. “…To some it is asymptomatic, or some sniffles, and to others it is a long road to recovery or worse, it alters the course of their entire life.”

    Spektor most recently released “Home, Before and After,” her eighth studio album and the first one in six years.

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  • Today in History: October 12, China arrests “Gang of Four”

    Today in History: October 12, China arrests “Gang of Four”

    Today in History

    Today is Wednesday, Oct. 12, the 285th day of 2022. There are 80 days left in the year.

    Today’s Highlight in History:

    On Oct. 12, 1976, it was announced in China that Hua Guofeng had been named to succeed the late Mao Zedong as chairman of the Communist Party; it was also announced that Mao’s widow and three others, known as the “Gang of Four,” had been arrested.

    On this date:

    In 1492 (according to the Old Style calendar), Christopher Columbus’ expedition arrived in the present-day Bahamas.

    In 1792, the first recorded U.S. celebration of Columbus Day was held to mark the tricentennial of Christopher Columbus’ landing.

    In 1870, General Robert E. Lee died in Lexington, Virginia, at age 63.

    In 1933, bank robber John Dillinger escaped from a jail in Allen County, Ohio, with the help of his gang, who killed the sheriff, Jess Sarber.

    In 1971, the rock opera “Jesus Christ Superstar” opened at the Mark Hellinger Theatre on Broadway.

    In 1973, President Richard Nixon nominated House minority leader Gerald R. Ford of Michigan to succeed Spiro T. Agnew as vice president.

    In 1984, British Prime Minister Margaret Thatcher escaped an attempt on her life when an Irish Republican Army bomb exploded at a hotel in Brighton, England, killing five people.

    In 1986, the superpower meeting in Reykjavik, Iceland, ended in stalemate, with President Ronald Reagan and Soviet leader Mikhail S. Gorbachev unable to agree on arms control or a date for a full-fledged summit in the United States.

    In 2000, 17 sailors were killed in a suicide bomb attack on the destroyer USS Cole in Yemen.

    In 2002, bombs blamed on al-Qaida-linked militants destroyed a nightclub on the Indonesian island of Bali, killing 202 people, including 88 Australians and seven Americans.

    In 2007, former Vice President Al Gore and the U.N.‘s Intergovernmental Panel on Climate Change won the Nobel Peace Prize for sounding the alarm over global warming.

    In 2011, a Nigerian al-Qaida operative pleaded guilty to trying to bring down a jetliner with a bomb in his underwear; Umar Farouk Abdulmutallab (OO’-mahr fah-ROOK’ ahb-DOOL’-moo-TAH’-lahb) defiantly told a federal judge in Detroit that he had acted in retaliation for the killing of Muslims worldwide.

    Ten years ago: Thousands of supporters and opponents of Egyptian President Mohammed Morsi clashed in Cairo’s Tahrir Square in the first such violence since Morsi took office more than three months earlier. The European Union won the Nobel Peace Prize for fostering peace on a continent long ravaged by war.

    Five years ago: The Trump administration said it would “immediately” halt payments to insurers under the Obama-era health care law. President Donald Trump lashed out at hurricane-devastated Puerto Rico, saying the federal government can’t keep sending help “forever” and suggesting that the U.S. territory was to blame for its financial struggles.

    One year ago: The New Jersey Nets said Kyrie Irving could not play or practice with them until he could be a full participant; New York City required professional athletes to be vaccinated against COVID-19 in order to play or practice in public venues. (Irving would be allowed to rejoin the team for out-of-town games in January 2022, and for home games two months later.) The head of the Chicago police officers union called on its members to defy the city’s requirement to report their COVID-19 vaccination status or be placed on unpaid leave. The Boeing Co. told employees they must be vaccinated against COVID-19 or possibly be fired. Florida issued its first fine to a county that it said had violated a new state law banning coronavirus vaccine mandates; Leon County was fined $3.5 million.

    Today’s Birthdays: Former Sen. Jake Garn, R-Utah, is 90. Singer Sam Moore (formerly of Sam and Dave) is 87. Broadcast journalist Chris Wallace is 75. Actor-singer Susan Anton is 72. Pop/rock singer/songwriter Jane Siberry is 67. Actor Hiroyuki Sanada is 62. Actor Carlos Bernard is 60. Jazz musician Chris Botti (BOH’-tee) is 60. R&B singer Claude McKnight (Take 6) is 60. Rock singer Bob Schneider is 57. Actor Hugh Jackman is 54. Actor Adam Rich is 54. R&B singer Garfield Bright (Shai) is 53. Country musician Martie Maguire (Courtyard Hounds, The Chicks) is 53. Actor Kirk Cameron is 52. Olympic gold medal skier Bode Miller is 45. Rock singer Jordan Pundik (New Found Glory) is 43. Actor Brian J. Smith is 41. Actor Tyler Blackburn is 36. Actor Marcus T. Paulk is 36. Actor Ito Aghayere is 35. Actor Josh Hutcherson is 30.

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  • Phage Trial to Treat CF Patients With Multi-Drug Resistant Bacterial Infections

    Phage Trial to Treat CF Patients With Multi-Drug Resistant Bacterial Infections

    Newswise — Cystic fibrosis (CF) is an inherited disorder that causes severe damage to the lungs and other organs in the body. Nearly 40,000 children and adults in the United States live with CF, an often difficult existence exacerbated by an opportunistic bacterium called Pseudomonas aeruginosa, which is a major cause of chronic, life-threatening lung infections.

    P. aeruginosa infections are not easily treated. The pathogen can be resistant to most current antibiotics. However, an early-stage clinical trial led by scientists at University of California San Diego School of Medicine, with collaborators across the country, has launched to assess the safety and efficacy of treating P. aeruginosa lung infections in CF patients with a different biological weapon: bacteriophages.

    Bacteriophages are viruses that have evolved to target and destroy specific bacterial species or strains. Phages are more abundant than all other life forms on Earth combined and are found wherever bacteria exist. Discovered in the early 20th century, they have long been investigated for their therapeutic potential, but increasingly so with the rise and spread of antibiotic-resistant bacteria.

    In 2016, scientists and physicians at UC San Diego School of Medicine and UC San Diego Health used an experimental intravenous phage therapy to successfully treat and cure colleague Tom Patterson, PhD, who was near death from a multidrug-resistant bacterial infection. Patterson’s was the first documented case in the U.S. to employ intravenous phages to eradicate a systemic bacterial infection. Subsequent successful cases helped lead to creation of the Center for Innovative Phage Applications and Therapeutics (IPATH) at UC San Diego, the first such center in North America.

    In 2020, IPATH researchers published data from 10 cases of intravenous bacteriophage therapy to treat multidrug-resistant bacterial infections, all at UC San Diego. In 7 of 10 cases, there was a successful outcome.

    The new phase 1b/2 clinical trial advances this work. The trial is co-led by Robert Schooley, MD, professor of medicine and an infectious disease expert at UC San Diego School of Medicine who is co-director of IPATH and helped lead the clinical team that treated and cured Patterson in 2016.

    It will consist of three elements, all intended to assess the safety and microbiological activity of a single dose of intravenous phage therapy in males and non-pregnant females 18 years and older, all residing in the United States.

    The dose is a cocktail of four phages that target P. aeruginosa, a bacterial species commonly found in the environment (soil and water) that can cause infections in the blood, lungs and other parts of the body after surgery.

    For persons with CF, P. aeruginosa is a familiar and sometimes fatal foe. The Cystic Fibrosis Foundation estimates that roughly half of all people with CF are infected by Pseudomonas. Previous studies have indicated that chronic P. aeruginosa lung infections negatively impact life expectancy of CF patients, who currently live, on average, to approximately 44 years.

    In the first stage of the trial, two “sentinel subjects” will receive one of three dosing strengths of the IV bacteriophage therapy. If, after 96 hours and no adverse effects, the second stage (2a) will enroll 32 participants into one of four arms: the three doses and a placebo.

    After multiple follow-up visits over 30 days and an analysis of which dosing strength exhibited the most favorable safety and microbiologic activity, i.e. most effective at reducing P. aeruginosa, stage 2b will recruit up to 72 participants to either receive that IV dose or a placebo.

    Enrollment will occur at 16 cystic fibrosis clinical research sites in the United States, including UC San Diego. It is randomized, double-blind and placebo-controlled. The trial is being conducted through the Antibacterial Resistance Leadership Group and funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, with additional support for the UC San Diego trial site from the Mallory Smith Legacy Fund.

    Mallory Smith was born with cystic fibrosis and died in 2017 at the age of 25 from a multidrug-resistant bacterial infection following a double lung transplant.

    “Mallory’s death was a preventable tragedy,” said her mother, Diane Shader Smith. “We are supporting the IPATH trial through Mallory’s Legacy Fund because Mark and I deeply believe in the promise of phage therapy to save lives by combatting multidrug-resistant bacteria.”

    In an article published in 2020 in Nature Microbiology, Schooley and Steffanie Strathdee, PhD, associate dean of global health sciences and Harold Simon Professor in the Department of Medicine and IPATH co-director, describe phages as “living antibiotics.”

    As such, said Schooley, researchers need to learn how to best use them to benefit patients through the same systematic clinical trials employed to evaluate traditional antibiotics.

    The primary objectives of the new trial are first to determine the safety of a single IV phage dose in clinically stable patients with CF who are also infected with P. aeruginosa, said Schooley.

    “Second, it’s to describe the microbiological activity of a single IV dose and third, to assess the benefit-to-risk profile for CF patients with P. aeruginosa infections. This is one study, with a distinct patient cohort and carefully prescribed goals. It’s a step, but an important one that can, if ultimately proven successful, help address the growing, global problem of antimicrobial resistance and measurably improve patients’ lives.”

    Estimated study completion date is early 2025.

    For more information on the clinical trial and participant eligibility criteria, visit clinicaltrials.gov or visit IPATH and click on the Contact Us button.

    # # #

    University of California San Diego

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  • Today in History: October 11, Anita Hill accuses Thomas

    Today in History: October 11, Anita Hill accuses Thomas

    Today in History

    Today is Tuesday, Oct. 11, the 284th day of 2022. There are 81 days left in the year.

    Today’s Highlight in History:

    On Oct. 11, 1986, President Ronald Reagan and Soviet leader Mikhail S. Gorbachev opened two days of talks in Reykjavik, Iceland, concerning arms control and human rights.

    On this date:

    In 1614, the New Netherland Co. was formed by a group of merchants from Amsterdam and Hoorn to set up fur trading in North America.

    In 1809, just over three years after the famous Lewis and Clark expedition ended, Meriwether Lewis was found dead in a Tennessee inn, an apparent suicide; he was 35.

    In 1884, American first lady Eleanor Roosevelt was born in New York City.

    In 1906, the San Francisco Board of Education ordered the city’s Asian students segregated in a purely “Oriental” school. (The order was later rescinded at the behest of President Theodore Roosevelt, who promised to curb future Japanese immigration to the United States.)

    In 1968, Apollo 7, the first manned Apollo mission, was launched with astronauts Wally Schirra (shih-RAH’), Donn Fulton Eisele and R. Walter Cunningham aboard. The government of Panama was overthrown in a military coup.

    In 1984, Challenger astronaut Kathryn D. Sullivan became the first American woman to walk in space as she and fellow Mission Specialist David C. Leestma spent 3 1/2 hours outside the shuttle.

    In 1991, testifying before the Senate Judiciary Committee, Anita Hill accused Supreme Court nominee Clarence Thomas of sexually harassing her; Thomas re-appeared before the panel to denounce the proceedings as a “high-tech lynching.”

    In 2002, former President Jimmy Carter was named the recipient of the Nobel Peace Prize.

    In 2005, the U.S. Army Corps of Engineers said it had finished pumping out the New Orleans metropolitan area, which was flooded by Hurricane Katrina six weeks earlier and then was swamped again by Hurricane Rita.

    In 2006, the charge of treason was used for the first time in the U.S. war on terrorism, filed against Adam Yehiye Gadahn (ah-DAHM’ YEH’-heh-yuh guh-DAHN’), also known as “Azzam the American,” who’d appeared in propaganda videos for al-Qaida. (Gadahn was killed by a U.S. drone strike in Pakistan in Jan. 2015.)

    In 2014, customs and health officials began taking the temperatures of passengers arriving at New York’s Kennedy International Airport from three West African countries in a stepped-up screening effort meant to prevent the spread of the Ebola virus.

    In 2020, the Los Angeles Lakers beat the Miami Heat 106-93 to win the NBA finals in six games; LeBron James scored 28 points as the NBA wrapped up a season that sent players to a “bubble” at Walt Disney World in Florida for three months because of the pandemic.

    Ten years ago: Vice President Joe Biden and Republican opponent Paul Ryan squared off in their only debate of the 2012 campaign; the two repeatedly interrupted each other as they sparred over topics including the economy, taxes and Medicare.

    Five years ago: The Boy Scouts of America announced that it would admit girls into the Cub Scouts starting in 2018 and establish a new program for older girls based on the Boy Scout curriculum, allowing them to aspire to the Eagle Scout rank. Strong winds fueled wildfires burning through California wine country; the confirmed death toll climbed to 23 as authorities ordered new evacuations. An American woman, Caitlan Coleman, her Canadian husband Joshua Boyle, and their children were freed, five years after they were seized by a terrorist network in the mountains of Afghanistan; officials said the couple and their three children – who’d been born in captivity – were rescued in a dramatic raid orchestrated by the U.S. and Pakistani governments.

    One year ago: Jon Gruden resigned as coach of the Las Vegas Raiders following reports about messages he wrote years earlier that used offensive terms to refer to Blacks, gays and women. U.S.-based economist David Card won the Nobel Prize in economics for pioneering research demonstrating that an increase in the minimum wage doesn’t hinder hiring, and immigrants don’t lower pay for native-born workers. Benson Kipruto and Diana Kipyogei completed a Kenyan sweep in the Boston Marathon, which took place after a 30-month absence; the race was moved from its traditional spring date for the first time in its 125-year history because of the coronavirus outbreak.

    Today’s Birthdays: Former U.S. Defense Secretary William Perry is 95. Actor Amitabh Bachchan is 80. Country singer Gene Watson is 79. Singer Daryl Hall (Hall and Oates) is 76. Sen. Patty Murray, D-Wash., is 72. Actor-director Catlin Adams is 72. Country singer Paulette Carlson is 71. Original MTV VJ Mark Goodman is 70. Actor David Morse is 69. Actor Stephen Spinella is 66. Actor-writer-comedian Dawn French is 65. Pro and College Football Hall of Famer Steve Young is 61. Actor Joan Cusack is 60. Rock musician Scott Johnson (Gin Blossoms) is 60. Comedy writer and TV host Michael J. Nelson is 58. Actor Sean Patrick Flanery is 57. Actor Lennie James is 57. College Football Hall of Famer and former NFL player Chris Spielman is 57. Country singer-songwriter Todd Snider is 56. Actor-comedian Artie Lange is 55. Actor Jane Krakowski is 54. Actor Andrea Navedo is 53. Actor Constance Zimmer is 52. Rapper MC Lyte is 52. Bluegrass musician Leigh Gibson (The Gibson Brothers) is 51. Figure skater Kyoko Ina is 50. Actor Darien Sills-Evans is 48. Actor/writer Nat Faxon is 47. Actor Emily Deschanel is 46. Actor Matt Bomer is 45. Actor Trevor Donovan is 44. Actor Robert Christopher Riley is 42. Actor Michelle Trachtenberg is 37. Actor Lucy Griffiths is 36. Golfer Michelle Wie is 33. Rapper Cardi B is 30.

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  • UN mulls quick foreign troop deployment to ease Haiti crisis

    UN mulls quick foreign troop deployment to ease Haiti crisis

    SAN JUAN, Puerto Rico — The United Nations Security Council on Monday was evaluating options including the immediate activation of foreign troops to help free Haiti from the grip of gangs that has caused a scarcity of fuel, water and other basic supplies.

    Such a force would “remove the threat posed by armed gangs and provide immediate protection to critical infrastructure and services,” as well as secure the “free movement of water, fuel, food and medical supplies from main ports and airports to communities and health care facilities,” according to a letter U.N. Secretary-General António Guterres submitted to the council on Sunday.

    The letter, which was seen by The Associated Press and has not been made public, said one or several member states would deploy the force to help Haiti’s National Police.

    It also states the secretary-general may deploy “additional U.N. capacities to support a ceasefire or humanitarian arrangements.”

    However, the letter notes that “a return to a more robust United Nations engagement in the form of peacekeeping remains a last resort if no decisive action is urgently taken by the international community in line with the outlined options and national law enforcement capacity proves unable to reverse the deteriorating security situation.”

    The letter was submitted after Haiti Prime Minister Ariel Henry and 18 high-ranking officials requested from international partners “the immediate deployment of a specialized armed force, in sufficient quantity,” to stop the “criminal actions” of armed gangs across the country.

    The request comes nearly a month after one of Haiti’s most powerful gangs seized control of a key fuel terminal in the capital of Port-au-Prince, where some 10 million gallons of diesel and gasoline and more than 800,000 gallons of kerosene are stored.

    Tens of thousands of demonstrators also have barricaded streets in Port-au-Prince and other major cities in recent weeks, preventing the flow of goods and traffic as part of an ongoing protest against a spike in the prices of gasoline, diesel and kerosene.

    Gas stations and schools are closed, while banks and grocery stores are operating on a limited schedule.

    Regis Wilguens, a 52-year-old businessman, said he doesn’t believe the anticipated arrival of foreign troops would change anything.

    “The results are always the same,” he said. “The social problems and economic problems have never been solved.”

    Protesters are demanding the resignation of Henry, who announced in early September that his administration could no longer afford to subsidize fuel.

    The deepening paralysis has caused supplies of fuel, water and other basic goods to dwindle amid a cholera outbreak that has killed several people and sickened dozens of others, with health officials warning that the situation could worsen.

    On Sunday, Haitian senators signed a document demanding that Henry’s “de facto government” defer its request for deployment of foreign troops, saying it is illegal under local laws.

    A spokesman for Henry could not be reached for comment.

    The possible presence of international armed forces is something that bothers Georges Ubin, a 44-year-old accountant, who said he knows of people who have been victimized by peacekeepers and believes foreign intervention would not improve things.

    “The foreign troops are not going to solve the major problems that Haiti has,” he said. “These are problems that have been around since I was born. It never gets better.”

    Haitian officials have not specified what kind of armed forces they’re seeking, with many local leaders rejecting the idea of U.N. peacekeepers, noting that they’ve been accused of sexual assault and of sparking a cholera epidemic that killed nearly 10,000 people during their a 13-year mission in Haiti that ended five years ago.

    The letter that the U.N. secretary-general submitted Sunday suggests that the rapid action force be phased out as Haitian police regain control of infrastructure, and that two options could follow: member states establish an international police task force to help and advise local officers or create a special force to help tackle gangs “including through joint strike, isolation and containment operations across the country.”

    The letter notes that if member states do not “step forward with bilateral support and financing,” the U.N. operation may be an alternative.

    “However, as indicated, a return to U.N. peacekeeping was not the preferred option of the authorities,” it states.

    The letter also says the Security Council could decide to strengthen the police component of the current United Nations Integrated Office in Haiti known as BINUH, and to call on member states to provide additional equipment and training to local police, which are understaffed and lack resources. Only about a third of some 13,000 are operational in a country of more than 11 million people.

    The secretary-general said the issue is a matter of urgency, noting Haiti “is facing an outbreak of cholera amid a dramatic deterioration in security that has paralyzed the country.”

    On Monday, Global Affairs Canada said it was extremely concerned about the impact of armed gang activity that has reached “an unprecedented level.”

    “We are carefully considering Prime Minister Ariel Henry’s appeal in consultation with Haitian authorities and our international partners,” the department said.

    It added that it supports targeted sanctions to stop armed gangs and those who finance violence and insecurity in Haiti.

    The U.S. Embassy in Haiti has granted temporarily leave to personnel and urged U.S. citizens to immediately leave the country.

    As U.N. officials and member states mull Haiti’s request, some people including 35-year-old Allens Hemest hope to see troops arrive soon. He is unemployed. Until recently, he worked at a factory that produced plastic cups but shut down amid the crisis.

    “The whole city is under siege,” he said. “If this is going to bring peace, I’m all for it. We can’t continue living like this.”

    ———

    Associated Press reporters Evens Sanon in Port-au-Prince, Haiti and Rob Gillies in Toronto contributed.

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  • UN ponders rapid armed force to help end Haiti’s crisis

    UN ponders rapid armed force to help end Haiti’s crisis

    SAN JUAN, Puerto Rico — U.N. Secretary-General António Guterres submitted a letter to the Security Council on Sunday proposing the immediate activation of a rapid action force following a plea for help from Haiti as gangs and protesters paralyze the country.

    The letter, which was seen by The Associated Press but has not been made public, said the rapid action force would be deployed by one or several member states to help Haiti’s National Police. That force would “remove the threat posed by armed gangs and provide immediate protection to critical infrastructure and services,” as well as secure the “free movement of water, fuel, food and medical supplies from main ports and airports to communities and health care facilities.”

    The letter also states the secretary-general may deploy “additional U.N. capacities to support a ceasefire or humanitarian arrangements.”

    However, the letter notes that “a return to a more robust United Nations engagement in the form of peacekeeping remains a last resort if no decisive action is urgently taken by the international community in line with the outlined options and national law enforcement capacity proves unable to reverse the deteriorating security situation.”

    The letter suggests that the rapid action force be phased out as Haitian police regain control of infrastructure, and that two options could follow: member states establish an international police task force to help and advise local officers or create a special force to help tackle gangs “including through joint strike, isolation and containment operations across the country.”

    The letter notes that if member states do not “step forward with bilateral support and financing,” the U.N. operation may be an alternative.

    “However, as indicated, a return to U.N. peacekeeping was not the preferred option of the authorities,” it states.

    The letter also says the Security Council could decide to strengthen the police component of the current United Nations Integrated Office in Haiti known as BINUH, and to call on member states to provide additional equipment and training to local police, which are understaffed and lack resources. Only about a third of some 13,000 are operational in a country of more than 11 million people.

    The secretary-general said the issue is a matter of urgency, noting Haiti “is facing an outbreak of cholera amid a dramatic deterioration in security that has paralyzed the country.”

    On Friday, Haiti’s government published an official document signed by Prime Minister Ariel Henry and 18 top-ranking officials requesting from international partners “the immediate deployment of a specialized armed force, in sufficient quantity,” to stop the “criminal actions” of armed gangs across the country.

    The request comes nearly a month after one of Haiti’s most powerful gangs surrounded a key fuel terminal in the capital of Port-au-Prince, preventing the distribution of some 10 million gallons of diesel and gasoline and more than 800,000 gallons of kerosene stored on site.

    Tens of thousands of demonstrators also have blocked streets in Port-au-Prince and other major cities in recent weeks, preventing the flow of traffic including water trucks and ambulances, as part of an ongoing protest against a spike in the prices of gasoline, diesel and kerosene.

    Gas stations and schools are closed, while banks and grocery stores are operating on a limited schedule.

    Protesters are demanding the resignation of Henry, who announced in early September that his administration could no longer afford to subsidize fuel.

    The deepening paralysis has caused supplies of fuel, water and other basic goods to dwindle amid a cholera outbreak that has killed several people and sickened dozens of others, with health officials warning that the situation could worsen amid a lack of potable water and cramped living conditions. More than 150 suspected cases have been reported, with the U.N. warning that the outbreak is spreading beyond Port-au-Prince.

    The outbreak comes as UNICEF warns that three-fourths of major hospitals across Haiti are unable to provide critical service “due to the fuel crisis, insecurity and looting.”

    The U.S. Embassy has granted temporarily leave to personnel and urged U.S. citizens to immediately leave Haiti.

    Haitian officials have not specified what kind of armed forces they’re seeking, with many local leaders rejecting the idea of U.N. peacekeepers, noting that they’ve been accused of sexual assault and of sparking a cholera epidemic that killed nearly 10,000 people during their a 13-year mission in Haiti that ended five years ago.

    A Brazilian general and former U.N. peace mission leader who declined to be identified because he is still involved with the U.N. told The Associated Press this weekend that any peacekeeping mission would be established following a decision by the Security Council if it believes there’s a risk to international security.

    The U.N. would send a team for evaluation, and then the Security Council would decide if money is available and which countries would be available for volunteering. He noted that a military mission could cost between 600 to 800 million dollars and would count with 7,000 military components, plus police and civil components.

    “It is an ongoing crisis, which makes it difficult for short term solutions,” he said. “There needs to be international help, no doubt about that.”

    ———

    Associated Press reporter Carla Bridi in Brasilia, Brazil contributed.

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  • A single mom’s 4 kids had to fend for themselves when tragedy struck. How a chance encounter years ago saved their future | CNN

    A single mom’s 4 kids had to fend for themselves when tragedy struck. How a chance encounter years ago saved their future | CNN



    CNN
     — 

    On a dark autumn evening almost four years ago, Janie Yoshida was driving her daughter home from high school play rehearsal when she noticed a teenager walking by himself next to a busy road.

    Tre Burrows, it turned out, was also in the play at Somerset Academy Canyons High School in Boynton Beach, Florida.

    “I pulled over to the side of the sidewalk and rolled the window down and said, ‘Hey, where do you live? I’ll take you home,’” Janie recalled.

    The 17-year-old kept insisting he was fine, until Janie put on “my mom’s voice” and demanded: ‘“Get in the car.”

    The polite young man with the gregarious smile complied. But, Janie soon learned, he led a life more challenging than she imagined – one in which she’d soon play a far bigger role.

    “He wanted me to drop him off at a main intersection. And I said, ‘Of course not. Just show me where you live.’ And he goes, ‘No, I can walk the rest of the way,’” Janie recalled.

    Reluctantly, Tre directed Janie to where he and his family were living.

    A motel.

    “I tried to play it off, like no big deal,” Janie recalled. But in reality, “I’m thinking to myself, ‘Oh my God … just terrible.’”

    From that point on, Janie gave Tre a ride every day after play rehearsal. Sometimes, she would make up an excuse to get fast food along the way, just to make sure Tre had a hot meal.

    “‘I don’t want to cook tonight,’” she’d tell him. “’Let’s just go through the drive thru.’”

    Then one day, Tre let slip another detail about his family life.

    “‘I’m gonna save this (meal),’” he told Janie, “’and split it with my sisters’” – one older and two younger, all together at the motel.

    Tre’s mother, it turned out, had been working two jobs and hanging by a thread to support her four children against immeasurable odds.

    Despite the financial challenges, Cindy Dawkins worked tirelessly to give her kids everything they needed. She had every meal ready, even without a kitchen. She helped with homework. Instead of asking her older ones to work part-time to support the family, she encouraged extracurricular activities such as track or school theater.

    Eventually, Tre told Janie why he’d been so nervous about telling anyone where he lived.

    “He didn’t want anybody to know because he was worried that the Department of Children and Families would come and take them away from his mom,” Janie said. “That’s just heartbreaking.”

    Janie asked to meet this matriarch – and was floored by her work ethic and strength.

    And as much as he loved his mom, Tre had no idea how much she sacrificed for her children.

    Soon, immense tragedy would force him to learn.

    A native of the Bahamas, Cindy moved to the US for what seemed like a promising career in the hospitality industry. But an avalanche of “bad luck on top of bad luck” fell on her, Janie said, including a layoff and a divorce.

    She ended up waitressing at two restaurants – one during the day, the other at night.

    “For the longest (time), she was working two jobs just to keep us afloat, paycheck to paycheck,” said Tre, now 21.

    “And she did all of that with a smile on her face because she didn’t want us to know exactly how hard it was to do all that.”

    But despite working two jobs, Cindy couldn’t get an apartment on her own because of a prior eviction. So she and her children moved into the motel, which cost far more per month than an apartment.

    The late Cindy Dawkins, with her daughter Zoe Clarke, moved to the US from the Bahamas.

    For three years, Cindy raised her four children in a motel room while working multiple jobs.

    Behind the omnipresent smile she put on for her kids, though, Cindy was struggling.

    She lamented that “‘in three years, I haven’t been able to make a home-cooked meal,’” Janie recalled.

    “She was like, ‘I don’t have a moment to myself or any privacy except when I’m in the shower. So if I’m going to break down, I’m going to cry, it’s going to be in the shower,’” Janie recalled.

    “‘And I’ve got to put my face back on, walk out of the bathroom in front of the kids and make sure that they don’t see it from me because I have to make them think everything’s OK.’”

    The family’s bad luck culminated the day Tre missed play rehearsal.

    The next day, Janie asked if he had been sick.

    “‘They kicked us out of the hotel because my mom couldn’t pay,’” Janie recalled him telling her.

    Janie went home and told her husband: “We need to get this family an apartment. I’m going tomorrow.”

    And as readily as she’d opened her car door to Tre that first time, “we just rented an apartment for them,” she said.

    With Janie’s name on the lease, the family of five moved into a two-bedroom apartment – mom in one bedroom, her four children sharing the other.

    Cindy meticulously paid the rent and utilities “earlier or on time – always,” Janie said.

    She got a raise at one of her restaurant jobs, Tre said, allowing her to quit her second job and spend more time with her kids.

    But that cherished time with her children would be short-lived.

    With a new home and better pay, Cindy and her kids eagerly anticipated celebrating her 50th birthday last summer.

    “We were planning on going up to Orlando a few days before and then spend her birthday up there,” Tre said.

    “We noticed that she started getting sick literally the day that we got there. As soon as we arrived, she went to bed and went to sleep and was just sleeping the entire time.”

    Cindy spent her birthday, August 1, in bed with severe Covid-19. The disease ravaged her body so quickly, “I didn’t even get to see her after she went into the hospital,” Tre said.

    On August 7, 2021 – six days after her birthday – Cindy died.

    Disbelief exacerbated her children’s agony.

    “She didn’t have any prior illnesses. … We just didn’t think anything like that would happen because we were healthy,” Tre said.

    “We were seeing the news (about) all the people passing away from Covid, but you never really understand exactly how bad it is until you experience it firsthand. We weren’t thinking this would completely uproot our lives.”

    Tre said his mother did not get vaccinated, in part due to rumors about side effects.

    “We didn’t want to do this and then (have it) potentially cause us to get sick,” Tre said. “We know better than that now. But I guess that was the reasoning behind her not getting” vaccinated.

    Tre and his siblings joined a growing group of children no one wants to be part of: the orphans of Covid. More than 212,000 US children have lost one or both parents to Covid-19, according to estimates from Imperial College London. And the number of children robbed of their parents keeps rising.

    “It never crossed my mind,” Tre said, “that me and my older sister would be the ones taking care of our little sisters.”

    Tre was the first to hear from the doctor his mother had passed. He rushed to the hospital and told his older sister, Jenny Burrows, now 25, to get there immediately.

    When Jenny arrived, “We cried for hours,” Tre recalled. “Our little sisters were at home (sleeping). Then we gathered ourselves and we tried to figure out, ‘OK, how are we going to tell our sisters?’”

    They woke up heir siblings Zoe Clarke, then 15, and Sierra Clarke, then 12. The most horrific nightmare had just turned into reality.

    The late Cindy Dawkins, with daughter Sierra Clarke, worked multiple jobs to support her children.

    But Tre and Jenny didn’t have time to mourn. Their minds were racing:

    “‘OK, are we about to get kicked out of the apartment we’re staying in because we can’t afford the bills?

    “‘How are we going to move on from this home?

    “‘How are we going to get the girls … everything they need for school?’”

    And the biggest question of all: Will the younger children get taken away?

    Despondent, overwhelmed and tasked with planning a funeral, Tre told Janie his mother passed.

    “I just lost it. I couldn’t believe it,” Janie said. “It was devastating.”

    She realized the siblings quickly needed help – and not just financially.

    They needed to learn how to parent on the fly.

    So once again, like she did all those years back from the driver’s seat, Janie went into mom mode.

    Without a living legal guardian, the children’s greatest fear was getting separated. Maybe the younger siblings would get taken away into state custody and foster care. Or maybe they would be sent to the Bahamas to live with relatives.

    Janie helped Jenny get to work on Priority No. 1: Becoming the younger girls’ legal guardian. It was one of the myriad legal complications that followed their mother’s death.

    “Another thing that’s helping us tremendously is we were able to get the girls set up with Social Security benefits from my mom,” Tre said, which will help support Sierra and Zoe until they turn 18.

    Janie and her husband also paid the remaining six months on the apartment’s lease. And she started a GoFundMe account, with an initial goal of paying for Cindy’s funeral expenses.

    Then just as Janie had stepped in as a stranger to help Tre’s hard-working but struggling family, hundreds more strangers did the same.

    The crowdsourcing fund grew so popular, it yielded enough for a down payment on a house so the children wouldn’t have to worry about getting evicted. Any extra funds likely will go toward Sierra’s and Zoe’s college education in the coming years.

    Janie also taught the older siblings about car insurance, credit and other life skills they would need to know immediately, now that they had dependents.

    Tre Burrows, left, and Jenny Burrows, right, became unexpected parents after their mom Cindy Dawkins died from Covid-19.

    The hardest part of being both a brother and a parent to younger siblings is “definitely the mental aspect of all of that,” Tre said.

    “The attitude stuff is a big thing for teenagers. They’re teenagers. Like getting chores done, getting your homework done, the attitude that comes with all that … basically, everything that goes with raising a 16- and 12-year-old,” he said.

    He and Jenny try to balance it all “while also making sure they don’t look at it like, ‘Oh, since Mom isn’t here, now you think you’re the boss and you can do all this stuff?’”

    And Tre tries to balance tough love with “not being too harsh with them, obviously, because we all just went through a horrible situation.”

    Tre and Jenny also now juggle a daily marathon of jobs, their own schooling and taking care of their sisters’ basic needs, their education and their mental health.

    Tre works at a computer repair company and has started training to become an emergency medical technician and firefighter. And Jenny, a dental assistant, wants to finish training to become a dental hygienist.

    The older siblings devised a plan for how to finish their education while paying the bills and taking care of the girls.

    “When I was going through EMT school … my sister would drop them off at school. I would pick them up, and (then) I would head to school. That was our plan,” Tre said.

    “And my sister would be the one at home with them, making sure they’re getting their homework done, making sure they’re OK mentally. And obviously I would help with that whenever I’m not in school. And basically I would get through that, get through the fire academy, doing the same thing,” he said.

    “And then once I’m done with schooling, the roles will kind of be reversed. So I’ll be the one that’s dropping them off, and I’ll be home with them (while) my sister’s at school, getting her career situated.”

    It’s a daunting task. But it’s nothing compared to what his own mother did, Tre said.

    “My biggest (concern) was just making sure I can fill her shoes,” he said. “I never really understood exactly how much she was doing until now, when my sister and I are the ones who have to do it.”

    Tre is also immensely grateful to the countless strangers who helped him and his siblings find a home and stay together.

    And it all traces to Janie giving him a ride home from school that dark autumn evening.

    “Without her,” he said, “we wouldn’t know what we would have done.”

    And Janie has learned from Cindy’s children, she said. Perhaps they inherited their mother’s fortitude.

    “I know they have the same instinct inside of them, just like their mom did – that hey, even if it sucks, let’s get up and make the best of it,” she said.

    “They’re my inspiration now.”

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  • Vaccination status, mortality among intubated patients with COVID-19–related acute respiratory distress syndrome

    Vaccination status, mortality among intubated patients with COVID-19–related acute respiratory distress syndrome

    About The Study: Full vaccination status compared with controls was associated with lower mortality among critically ill patients who required invasive mechanical ventilation owing to COVID-19–related acute respiratory distress syndrome in this study including 265 patients. These results may inform discussions with families about prognosis.

    Authors: Ilias I. Siempos, M.D., D.Sc., of the National and Kapodistrian University of Athens Medical School in Athens, Greece, is the corresponding author.

    To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  

    (doi:10.1001/jamanetworkopen.2022.35219)

    Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

    #  #  #

    Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2022.35219?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=100722

    About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

    JAMA – Journal of the American Medical Association

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  • Large number of U.S. COVID deaths could be prevented if patients would take Pfizer’s Paxlovid, White House coordinator warns

    Large number of U.S. COVID deaths could be prevented if patients would take Pfizer’s Paxlovid, White House coordinator warns

    A large number of U.S. COVID deaths could be prevented if patients would take Paxlovid, the antiviral developed by Pfizer
    PFE,
    -1.79%

    that helps reduce the risk of hospitalization and death, according to White House COVID coordinator Dr. Ashish Jha.

    Jha told the New York Times that the average daily death count could be reduced to about 50 a day from 400 currently, if every American aged 50 and above that tests positive for the virus took a course of either Paxlovid or used monoclonal antibodies.

     “The public doesn’t seem to understand that the evidence around hospitalization and deaths is really powerful,” Dr. Robert Wachter, chair of medicine at the University of California in San Francisco told the paper.

    The issue seems to be a combination of worry about certain issues that Paxlovid can cause, including a strange metallic taste and the potential for “rebound COVID,” where patients quickly become reinfected after the five-day course of pills has been completed. That happened to both President Joe Biden and first lady Jill Biden recently.

    The second reason is that many Americans — and Republicans, in particular — have refused to take COVID seriously and are not willing to take steps to reduce its impact. Trials have found Paxlovid to be effective across all age groups, but mostly among older patients. But as the COVID death rate for people under 50 is already close to zero, reducing it in a statistically significant way is difficult.

    See now: CDC scraps travel health notices as countries slow testing, and study confirms Republican-leaning counties suffered more COVID deaths than Democrat-leaning ones

    “I think almost everybody benefits from Paxlovid,” Jha said. “For some people, the benefit is tiny. For others, the benefit is massive.” 

    Yet a smaller share of 80-year-olds with COVID in the U.S. is taking it than 45-year-olds, Jha said citing data he has seen.

    From the CDC: Stay Up to Date with COVID-19 Vaccines Including Boosters

    The news comes as U.S. known cases of COVID are continuing to ease and now stand at their lowest level since late April, although the true tally is likely higher given how many people are testing at home, with data generally not being collected.

    The daily average for new cases stood at 41,605 on Thursday, according to a New York Times tracker, down 25% from two weeks ago. Cases are declining in northeastern states including New York and New Jersey, while cases are rising in the western states Montana, Washington and Oregon.

    The daily average for hospitalizations was down 11% at 27,021, while the daily average for deaths is down 8% to 391.

    Coronavirus Update: MarketWatch’s daily roundup has been curating and reporting all the latest developments every weekday since the coronavirus pandemic began

    Other COVID-19 news you should know about:

    • Molnupiravir, the COVID pill developed by Merck
    MRK,
    +0.18%

    and privately held Ridgeback Therapeutics, produced mixed results in two recent studies, the companies said Thursday. Early data from a trial conducted in the U.K. by the University of Oxford found no evidence of a difference when molnupiravir was added to usual care in reducing hospitalizations and death. A second study conducted in Israel found a benefit in patients who were 65 and older, but no benefit for 40- to 60-year-olds.

    • Homelessness is surging in the U.S. again as pandemic programs that halted evictions are being phased out, the Associated Press reported. The overall number of homeless people in a federal report to be released in the coming months is expected to be higher than the 580,000 unhoused before the coronavirus outbreak, the National Alliance to End Homelessness said. The AP tallied results from city-by-city surveys conducted earlier this year and found the number of people without homes is up overall compared with 2020 in areas reporting results so far.

    • The idea was to have China in stable and tip-top shape when thousands of delegates gather in Beijing to usher in a historic third term in power for Xi Jinping, BBC News reported. However, the coronavirus is not playing nicely. In recent weeks, tens of millions of people have again been confined to their homes in lockdowns across 60 towns and cities, and this is bringing political pressure on the man who has become the most powerful Chinese figure since the first communist-era leader, Mao Zedong.

    Covid-19 lockdowns, corruption crackdowns and more have put China’s economy on a potential crash course. WSJ’s Dion Rabouin explains how China’s economic downturn could harm the U.S. and the rest of the world. Illustration: David Fang

    • A new COVID-19 wave appears to be brewing in Europe as cooler weather arrives, with public health experts warning that vaccine fatigue and confusion over types of available vaccines will likely limit booster uptake, Reuters reported. The omicron subvariants BA.4 and BA.5 that dominated this summer are still behind the majority of infections, but newer omicron subvariants are gaining ground. Hundreds of new forms of omicron are being tracked by scientists, the World Health Organization said this week.

    Here’s what the numbers say:

    The global tally of confirmed cases of COVID-19 topped 620.5 million on Friday, while the death toll rose above 6.55 million, according to data aggregated by Johns Hopkins University.

    The U.S. leads the world with 96.6 million cases and 1,062,130 fatalities.

    The Centers for Disease Control and Prevention’s tracker shows that 225.8 million people living in the U.S., equal to 68% of the total population, are fully vaccinated, meaning they have had their primary shots. Just 110.5 million have had a booster, equal to 48.9% of the vaccinated population, and 24.8 million of those who are eligible for a second booster have had one, equal to 37.9% of those who received a first booster.

    Some 11.5 million people have had a shot of the new bivalent booster that targets the new omicron subvariants.

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  • Opinion: The Fed doesn’t have a choice anymore. Get ready for a recession | CNN Business

    Opinion: The Fed doesn’t have a choice anymore. Get ready for a recession | CNN Business

    Editor’s Note: Gad Levanon is the chief economist at the Burning Glass Institute. He’s the former head of The Conference Board’s Labor Market Institute. The opinions expressed in this commentary are his own.

    To many economists and analysts, the US economy has represented a paradox this year. On the one hand, GDP growth has slowed significantly, and some argue, even entered a recession. On the other hand, overall employment growth has been much stronger than normal.

    While GDP declined at an annualized rate of 1.1% in the first half of 2022, the US economy added 2.3 million jobs in the last six months, far more than in any other six-month period in the 20 years prior to the pandemic.

    This tight labor market – and the rapid wage growth it has spurred – is causing inflation to become more entrenched. The Consumer Price Index, which measures a basket of goods and services, was 8.3% year-over-year in August. That’s lower than the 40-year high of 9.1% in June, but still painfully high. To address it, the Federal Reserve is likely to drive the economy into a recession in 2023, crushing continued job growth.

    Why has employment growth remained so strong? First, the US economy is holding on better than many expected. The Atlanta Fed’s GDPNow estimate for real GDP growth in the third quarter of 2022 is 2.3%, suggesting that while the economy is now growing much more slowly than it did last year, we are still not in a recession. When the demand for goods and services strengthens, so does the demand for workers producing these goods and services.

    Second, despite the slowing of the economy and the growing fears of recession, layoffs are still historically low. Initial claims for unemployment insurance, an indicator highly correlated with layoffs, were 219,000 for the week ended October 1 – higher than the week prior, but still one of the lowest readings in recent decades. After years of increasingly traumatic labor shortages, many employers are reluctant to significantly reduce the number of workers even as their businesses are slowing. That’s because companies are worried that they will have trouble recruiting new workers when they start expanding again.

    Third, many industries are growing faster than normal because they are still recovering from the pandemic. Convention and trade show organizers, car rental companies, nursing homes and child day care services, among others, are all growing fast because they are still well below pre-pandemic employment levels.

    Fourth, just as some industries are growing because they are still catching up, others are experiencing high growth as they adjust to a new normal of higher demand. Demand for data processing and hosting services, semiconductor manufacturing, mental health services, testing laboratories, medical equipment and pharmaceutical manufacturing is higher than before the pandemic. And it’s likely that these represent structural changes to buying patterns that will keep demand high.

    Fifth, during the pandemic, corporate investments in software and R&D reached unprecedented levels, which drove a rapid increase in new STEM jobs. Because these workers are especially well paid, they have had plenty of disposable income to spend on goods and services, which has supported job growth throughout the economy.

    These factors are spurring positive momentum that will not disappear overnight. Employment growth is likely to slow down from its historically high rates, but it will still remain solid in the coming months. ManpowerGroup’s Employment Outlook Survey shows that the hiring intentions for the fourth quarter are still very high, despite dropping from the previous quarter.

    Next year, however, will look very different. Many of the industries that are still recovering from the pandemic will have reached pre-pandemic employment levels. With demand saturated, those industries may revert to slower hiring. But this alone is unlikely to push job growth into negative territory. What will do that is monetary policy.

    There are two ways to rein in the labor market: Either reduce demand for workers or increase the labor supply. But it’s hard to engineer a boost in labor supply. That takes the kind of legislative action needed to increase immigration, drive people into the labor force or grow investment in workforce training. This is likely to prove elusive in today’s polarized political environment.

    The only option that leaves the Fed is to engineer a recession by continuing to raise interest rates. Expect to see that happen in 2023.

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  • Today in History: October 7, Fox News Channel’s debut

    Today in History: October 7, Fox News Channel’s debut

    Today in History

    Today is Friday, Oct. 7, the 280th day of 2022. There are 85 days left in the year.

    Today’s Highlight in History:

    On Oct. 7, 1991, University of Oklahoma law professor Anita Hill publicly accused Supreme Court nominee Clarence Thomas of making sexually inappropriate comments when she worked for him; Thomas denied Hill’s allegations and would go on to win Senate confirmation.

    On this date:

    In 1765, the Stamp Act Congress convened in New York to draw up colonial grievances against England.

    In 1916, in the most lopsided victory in college football history, Georgia Tech defeated Cumberland University 222-0 in Atlanta.

    In 1949, the Republic of East Germany was formed.

    In 1982, the Andrew Lloyd Webber-Tim Rice musical “Cats” opened on Broadway. (The show closed Sept. 10, 2000, after a record 7,485 performances.)

    In 1985, Palestinian gunmen hijacked the Italian cruise ship Achille Lauro (ah-KEE’-leh LOW’-roh) in the Mediterranean. (The hijackers shot and killed Leon Klinghoffer, a Jewish-American tourist in a wheelchair, and pushed him overboard, before surrendering on Oct. 9.)

    In 1989, Hungary’s Communist Party renounced Marxism in favor of democratic socialism during a party congress in Budapest.

    In 1992, trade representatives of the United States, Canada and Mexico initialed the North American Free Trade Agreement during a ceremony in San Antonio, Texas, in the presence of President George H.W. Bush, Canadian Prime Minister Brian Mulroney (muhl-ROO’-nee) and Mexican President Carlos Salinas de Gortari.

    In 1996, Fox News Channel made its debut.

    In 1998, Matthew Shepard, a gay college student, was beaten and left tied to a wooden fencepost outside of Laramie, Wyoming; he died five days later. (Russell Henderson and Aaron McKinney are serving life sentences for Shepard’s murder.)

    In 2001, the war in Afghanistan started as the United States and Britain launched air attacks against military targets and Osama bin Laden’s training camps in the wake of the September 11 attacks.

    In 2003, California voters recalled Gov. Gray Davis and elected Arnold Schwarzenegger their new governor.

    In 2020, President Donald Trump returned to the Oval Office for the first time since he was diagnosed with COVID-19; he credited an experimental drug treatment with helping his recovery. Debating from behind plexiglass shields, Vice President Mike Pence and Democrat Kamala Harris zeroed in on Trump’s handling of the coronavirus pandemic, with Harris labeling it “the greatest failure of any presidential administration” while Pence defended the overall response.

    Ten years ago: Venezuelan President Hugo Chavez won re-election for the third time. (Chavez died in March 2013 at age 58 after a two-year battle with cancer; he was succeeded by Vice President Nicolas Maduro.)

    Five years ago: Country music star Jason Aldean, who had been on stage at an outdoor concert in Las Vegas less than a week earlier when a gunman opened fire on the crowd, paid tribute to the victims and to the late Tom Petty by opening “Saturday Night Live” with Petty’s song, “I Won’t Back Down.” Protesters rallied across Russia in a challenge to President Vladimir Putin on his 65th birthday; heeding calls from opposition leader Alexei Navalny to pressure authorities into letting him enter the presidential race.

    One year ago: Abortions quickly resumed in at least six Texas clinics after a federal judge halted the most restrictive abortion law in the nation. (A federal appeals court would allow the law to go back into effect the following day.) The Senate dodged a U.S. debt disaster, voting to extend the government’s borrowing authority into December and temporarily avert an unprecedented federal default. (The House would approve the extension days later.) Google said it would crack down on digital ads promoting false claims about climate change, in hopes of limiting revenue for climate change deniers and stopping the spread of misinformation.

    Today’s Birthdays: Author Thomas Keneally is 87. Comedian and talk-show host Joy Behar is 80. Former National Security Council aide Lt. Col. Oliver North (ret.) is 79. Rock musician Kevin Godley (10cc) is 77. Actor Jill Larson is 75. Country singer Kieran Kane is 73. Singer John Mellencamp is 71. Rock musician Ricky Phillips is 71. Russian President Vladimir Putin is 70. Actor Mary Badham (Film: “To Kill a Mockingbird”) is 70. Rock musician Tico Torres (Bon Jovi) is 69. Actor Christopher Norris is 67. Cellist Yo-Yo Ma is 67. Gospel singer Michael W. Smith is 65. Olympic gold medal ice dancer Jayne Torvill is 65. Actor Dylan Baker is 64. Actor Judy Landers is 64. Recording executive and TV personality Simon Cowell is 63. Actor Paula Newsome is 61. Country singer Dale Watson is 60. Pop singer Ann Curless (Expose) is 59. R&B singer Toni Braxton is 55. Rock singer-musician Thom Yorke (Radiohead) is 54. Rock musician-dancer Leeroy Thornhill is 53. Actor Nicole Ari Parker is 52. Actor Allison Munn is 48. Rock singer-musician Damian Kulash (KOO’-lahsh) is 47. Singer Taylor Hicks is 46. Actor Omar Miller is 44. Neo-soul singer Nathaniel Rateliff (Nathaniel Rateliff & the Night Sweats) is 44. Actor Shawn Ashmore is 43. Actor Jake McLaughlin is 40. Electronic musician Flying Lotus (AKA Steve Ellison) is 39. MLB player Evan Longoria is 37. Actor Holland Roden is 36. Actor Amber Stevens is 36. MLB outfielder Mookie Betts is 30. Actor Lulu Wilson is 17.

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  • U.S. risks prolonging pandemic if it doesn’t back WTO push to get vaccines and treatments to lower-income countries, lawmakers warn

    U.S. risks prolonging pandemic if it doesn’t back WTO push to get vaccines and treatments to lower-income countries, lawmakers warn

    The U.S. is at risk of prolonging the COVID pandemic if it fails to back an initiative that aims to get vaccines, diagnostics and treatments to lower-income countries, a congressional group has told President Joe Biden.

    In a letter to Biden from the group led by Earl Blumenauer, a Democrat from Oregon, the group urged him to back the World Trade Organization’s agreement in June to ease exports of lifesaving therapies.

    With more than 600 million shots in arms, 21,500 free testing sites, the ability to order at-home tests for free, and more treatments available now than at any point in the pandemic, the outlook in the United States is better than ever. Unfortunately, however, the prospect for many low-income countries is not so positive — putting the United States’ own success in jeopardy,” the lawmakers wrote.

    The letter was sent ahead of a meeting of the WTO council for trade-related aspects of IP rights that is due to kick off Thursday.

    The group noted that lower-income countries are facing a higher risk of severe illness, hospitalization and death as only a small percentage of their populations are vaccinated. Just 19% of people in those countries are vaccinated, compared with about 75% in high-income countries, according to the Multilateral Leaders Taskforce on COVID-19, a joint initiative of the International Monetary Fund, the World Bank, the World Health Organization and the WTO.

    U.S. known cases of COVID are continuing to ease and now stand at their lowest level since late April, although the true tally is likely higher given how many people are testing at home, where the data are not being collected.

    The daily average for new cases stood at 43,149 on Wednesday, according to a New York Times tracker, down 23% from two weeks ago. Cases are rising in most northeastern states by 10% of more, while cases in the western states Montana, Washington and Oregon are rising.

    The daily average for hospitalizations was down 11% at 27,184, while the daily average for deaths is down 8% to 391. 

    The new bivalent vaccine might be the first step in developing annual Covid shots, which could follow a similar process to the one used to update flu vaccines every year. Here’s what that process looks like, and why applying it to Covid could be challenging. Illustration: Ryan Trefes

    Coronavirus Update: MarketWatch’s daily roundup has been curating and reporting all the latest developments every weekday since the coronavirus pandemic began

    Other COVID-19 news you should know about:

    • China’s huge Xinjiang region has been hit with sweeping COVID travel restrictions ahead of a key Communist Party congress later this month, the Associated Press reported. Trains and buses in and out of the region of 22 million people have been suspended, and passenger numbers on flights have been reduced to 75% of capacity in recent days, according to Chinese media reports. The region is home to minorities who have been forced into prison-like re-education centers to force them to renounce their religion, typically Islam, and allegedly subjected to human-rights abuses.

    • Five current or former Internal Revenue Service workers have been charged with fraud for illegally getting money from federal COVID-19 relief programs and using a total of $1 million for luxury items and personal trips, prosecutors said, the AP reported. The U.S. attorney’s office in Memphis said Tuesday that the five have been charged with wire fraud after they filed fake applications for the Paycheck Protection Program and the Economic Injury Disaster Loan Program, which were part of a federal stimulus package tied to the pandemic response in 2020.

    • Peloton Interactive Inc.
    PTON,
    +3.84%

    said it plans to cut about 500 jobs, roughly 12% of its remaining workforce, in the company’s fourth round of layoffs this year as the connected fitness-equipment maker tries to reverse mounting losses, the Wall Street Journal reported. After enjoying a strong run early on in the pandemic, Peloton has struggled since the start of the U.S. recovery, and CEO Barry McCarthy, who took over in February, said he is giving the unprofitable company another six months or so to significantly turn itself around and, if it fails, Peloton likely isn’t viable as a stand-alone company.

    Don’t missPeloton CEO says ‘naysayers’ are looking at the company’s $1.2 billion quarterly loss all wrong.

    Here’s what the numbers say:

    The global tally of confirmed cases of COVID-19 topped 619.9 million on Wednesday, while the death toll rose above 6.55 million, according to data aggregated by Johns Hopkins University.

    The U.S. leads the world with 96.6 million cases and 1,061,490 fatalities.

    The Centers for Disease Control and Prevention’s tracker shows that 225.3 million people living in the U.S., equal to 67.9% of the total population, are fully vaccinated, meaning they have had their primary shots. Just 109.9 million have had a booster, equal to 48.8% of the vaccinated population, and 23.9 million of those who are eligible for a second booster have had one, equal to 36.6% of those who received a first booster.

    Some 7.6 million people have had a shot of one of the new bivalent boosters that target the new omicron subvariants that have become dominant around the world.

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  • Today in History: October 6, the launch of Instagram

    Today in History: October 6, the launch of Instagram

    Today in History

    Today is Thursday, Oct. 6, the 279th day of 2022. There are 86 days left in the year.

    Today’s Highlight in History:

    On Oct. 6, 1973, war erupted in the Middle East as Egypt and Syria launched a surprise attack on Israel during the Yom Kippur holiday. (Israel, initially caught off guard, managed to push back the Arab forces before a cease-fire finally took hold in the nearly three-week conflict.)

    On this date:

    In 1536, English theologian and scholar William Tyndale, who was the first to translate the Bible into Early Modern English, was executed for heresy.

    In 1927, the era of talking pictures arrived with the opening of “The Jazz Singer” starring Al Jolson, a feature containing both silent and sound-synchronized sequences.

    In 1928, Chiang Kai-shek became president of China.

    In 1939, in a speech to the Reichstag, German Chancellor Adolf Hitler spoke of his plans to reorder the ethnic layout of Europe — a plan that would entail settling the “Jewish problem.”

    In 1976, President Gerald R. Ford, in his second presidential debate with Democrat Jimmy Carter, asserted that there was “no Soviet domination of eastern Europe.” (Ford later conceded such was not the case.)

    In 1979, Pope John Paul II, on a week-long U.S. tour, became the first pontiff to visit the White House, where he was received by President Jimmy Carter.

    In 1981, Egyptian President Anwar Sadat was shot to death by extremists while reviewing a military parade.

    In 2003, American Paul Lauterbur and Briton Peter Mansfield won the Nobel Prize for medicine for discoveries that led to magnetic resonance imaging.

    In 2010, social networking app Instagram was launched by Kevin Systrom and Mike Krieger.

    In 2014, the Supreme Court unexpectedly cleared the way for a dramatic expansion of gay marriage in the United States as it rejected appeals from five states seeking to preserve their bans, effectively making such marriages legal in 30 states.

    In 2018, in the narrowest Senate confirmation of a Supreme Court justice in nearly a century and a half, Brett Kavanaugh was confirmed by a 50-48 vote; he was sworn in hours later.

    In 2020, President Donald Trump, recovering from COVID-19, tweeted his eagerness to return to the campaign trail and said he still planned to attend an upcoming debate with Democrat Joe Biden in Miami; Biden said there should be no debate as long as Trump remained COVID positive. (The debate would be canceled.)

    Ten years ago: Five terror suspects, including Egyptian-born preacher Mustafa Kamel Mustafa, widely known as Abu Hamza al-Masri, arrived in the United States from England and appeared in court in New York and Connecticut. (Mustafa was convicted in 2014 of supporting terrorist organizations.)

    Five years ago: The board of directors of The Weinstein Co. said movie mogul Harvey Weinstein was on indefinite leave from the company he founded amid an internal investigation into sexual harassment allegations against him. The International Campaign to Abolish Nuclear Weapons, a grassroots effort aimed at pressuring the world’s nuclear powers to give up those weapons, won the Nobel Peace Prize.

    One year ago: A federal judge ordered Texas to suspend a new law that had banned most abortions in the state since September. (An appeals court would reinstate the law two days later.) The Los Angeles City Council voted to enact one of the nation’s strictest vaccine mandates; it required the shots for everyone entering bars, restaurants, nail salons, gyms and even a Lakers game. The World Health Organization endorsed the world’s first malaria vaccine and said it should be given to children across Africa in the hope that it would spur stalled efforts to curb the spread of the parasitic disease; the vaccine was developed by GlaxoSmithKline in 1987.

    Today’s Birthdays: Broadcaster and writer Melvyn Bragg is 83. Actor Britt Ekland is 80. The former leader of Sinn Fein (shin fayn), Gerry Adams, is 74. Singer-musician Thomas McClary is 73. Musician Sid McGinnis is 73. Rock singer Kevin Cronin (REO Speedwagon) is 71. Rock singer-musician David Hidalgo (Los Lobos) is 68. Pro Football Hall of Famer Tony Dungy is 67. Actor Elisabeth Shue is 59. Singer Matthew Sweet is 58. Actor Jacqueline Obradors is 56. Country singer Tim Rushlow is 56. Rock musician Tommy Stinson is 56. Actor Amy Jo Johnson is 52. Actor Emily Mortimer is 51. Actor Lamman (la-MAHN’) Rucker is 51. Actor Ioan Gruffudd (YOH’-ihn GRIH’-fihth) is 49. Actor Jeremy Sisto is 48. Actor Brett Gelman is 46. R&B singer Melinda Doolittle is 45. Actor Wes Ramsey is 45. Actor Karimah Westbrook is 44. Singer-musician Will Butler is 40. Actor Stefanie Martini is 32.

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  • UCLA Fielding School of Public Health-led research demonstrates the importance of influenza vaccination globally

    UCLA Fielding School of Public Health-led research demonstrates the importance of influenza vaccination globally

    Newswise — LOS ANGELES (Oct. 5, 2022) – An international team of researchers has demonstrated that among patients hospitalized for influenza, those who were vaccinated had less severe infections, including reducing the odds for children requiring admittance to an intensive care unit by almost half.

    In addition, the researchers found that deaths among hospitalized adults, 65 or older, who had been vaccinated were 38% lower compared to those who had not been vaccinated.

    “A common complaint about influenza vaccine is that they are typically 40-60% effective against infection – or the ‘what’s the point?’ complaint. So it is important to note that although everyone in this study was hospitalized, vaccinated individuals were less likely to be severely ill or die, suggesting that you are likely to have far less severe consequences if vaccinated,” said Dr. Annette Regan, UCLA Fielding School of Public Health assistant professor of epidemiology and lead author of the peer-reviewed research, published this week in the October edition of The Lancet Infectious Diseases. “This is an important point, especially in light of the upcoming influenza season coupled with ongoing COVID-19 activity, both this season and into the future.”

    Globally, influenza contributes to 9.5 million hospitalizations, 81.5 million hospital days, and 145,000 deaths each year. Vaccination offers the best method of preventing influenza illness, reducing illness in the general population by 40–60%, experts say.

    Specifically, The Lancet analysis found that three groups routinely targeted for influenza vaccination experiences less severe illness. Children who had received only part of their first series of influenza vaccines had 36% lower chances of being admitted to an intensive care unit (ICU), and children who had fully completed their first series of influenza vaccines had 48% lower chances of admission to ICU compared to unvaccinated children, the researchers found.

    The study – “Severity of influenza illness associated with seasonal influenza vaccination among hospitalized patients in four South American countries” – is the product of an international team of researchers from the United States, Argentina, Brazil, Chile, and Paraguay, and drew on data from all four South American countries over a period of seven years. Data were obtained through the Network for the Evaluation of Vaccine Effectiveness in Latin America and the Caribbean, influenza (REVELAC-i) which is coordinated by the Pan American Health Organization (PAHO).

    “Although several studies have reported drops in influenza illness following influenza vaccination, the results have focused predominantly on adults in the United States, and this study aimed to evaluate the severity of influenza illness by vaccination status in a broad range of age groups, and across multiple South American countries,” said Dr. Marta Von Horoch, a co-author who serves as coordinator of the National Immunization Program in Paraguay. “We were very pleased to work with our partners in the U.S. and across the continent, and these findings demonstrate, quite clearly, the importance of influenza vaccination for children and adults, no matter where they live.”

    The study – the first-ever on this scale in South America – examined influenza-related hospitalization rates and outcomes across all four countries from 2013-19. Specifically, the analysts reviewed the outcomes for some 2,747 patients hospitalized with confirmed influenza virus infection, in three age groups – children aged 6–24 months, adults aged 18–64 years, and adults aged 65 years or older.

    Given the reality that vaccination rates have fallen, in the U.S. and globally during the COVID-19 pandemic, including among children, the findings should help make clear the benefits of timely, pro-active immunization campaigns to the public, the researchers said.

    “With influenza season approaching this winter and influenza vaccines now available, these results highlight the importance of getting vaccinated for flu for anyone six months of age or older – as CDC recommends,” Regan said. “It is critical that healthcare providers and the public understand the risks of missing out on vaccinations – it is so much better to prevent a serious illness than to suffer through it, for the patient and everyone in their community.”

    PRINCIPAL INVESTIGATOR: Regan, also a faculty affiliate with UCLA’s Bixby Center on Population and Reproductive Health, has taught at the university since 2019. She earned her PhD from the University of Western Australia in 2016. As part of her doctoral work, Regan established one of the largest population-based cohorts to investigate the safety of influenza vaccination in pregnancy and Australia’s first rapid surveillance system for monitoring the safety of vaccines given during pregnancy. She is also currently leading a large U.S. study on COVID-19 vaccination during pregnancy. Regan has served as an epidemiologist with the Western Australia Department of Health (2013-16) and Epidemiologist for the U.S. Centers for Disease Control and Prevention (2007-11). She is also on faculty at the University of San Francisco’s School of Nursing and Health Professions.

    METHODS: Using surveillance data from four South American countries, the team examined indicators of severity of illness among influenza-associated hospitalizations, including length of hospital stay, admission to ICU, and death in hospital. Data collection conformed to a common protocol, reducing heterogeneity in measurements. As a result, the researchers were able to evaluate the health effects associated with influenza vaccination in a large sample of three priority groups, including children aged 6–24 months. The large sample size also enabled analyses by influenza virus subtype and by number of pre-existing health conditions. The results for each group was subjected to separate statistical analyses.

    FUNDING: This work was supported by a grant from the U.S. Centers for Disease Control and Prevention (CDC) through cooperative agreements with the Pan American Health Organization and the World Health Organization.

    CITATION: Regan A, Arriola CS, Couto P, et al. Severity of influenza illness associated with seasonal influenza vaccination among hospitalised patients in four South American countries, 2013–19: a surveillance-based cohort study. Lancet Infectious Diseases, S1473-3099(22)00493-5.

    ============================

    The UCLA Fielding School of Public Health, founded in 1961, is dedicated to enhancing the public’s health by conducting innovative research, training future leaders and health professionals from diverse backgrounds, translating research into policy and practice, and serving our local communities and the communities of the nation and the world. The school has 761 students from 26 nations engaged in carrying out the vision of building healthy futures in greater Los Angeles, California, the nation and the world.

    UCLA Fielding School of Public Health

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  • The determinants of persistent and severe COVID-19 revealed

    The determinants of persistent and severe COVID-19 revealed

    Newswise — As COVID-19 wreaks havoc across the globe, one characteristic of the infection has not gone unnoticed. The disease is heterogeneous in nature with symptoms and severity of the condition spanning a wide range. The medical community now believes this is attributed to variations in the human hosts’ biology and has little to do with the virus per se. Shedding some light on this conundrum are Associate Professor SUMI Tomonari from Okayama University, Research Institute for Interdisciplinary Science (RIIS) and Associate Professor Kouji Harada from Toyohashi University of Technology, the Center for IT-based Education (CITE). The duo recently reported their findings on imbalances in the host immune system that facilitate persistent or severe forms of the disease in some patients.

    The researchers commenced their study by computer simulations with models based on a host’s immune system and its natural response to SARS-CoV-2 exposure. Mathematical equations for the dynamics of cells infected by SARS-CoV-2 were plugged in to predict their behavior. Now, the immune system has messenger cells known as dendritic cells (DCs). These cells report information (in the form of antigens) about the invaders to the warriors, or T cells, of the immune system. The model showed that at the onset of infection, DCs from infected tissues were activated and then antibodies to neutralize SARS-CoV-2 gradually started building.

    To investigate long-term COVID-19, the behavior of DCs 7 months after infection was evaluated by the computer simulation. the baseline model simulation revealed that DCs drastically decreased during the peak of infection and slowly built up again. However, they tended to remain below pre-infection levels. These observations were similar to those seen in clinical patient samples. It seemed like low DC levels were associated with tenacious long-term infection.

    The subsequent step was to understand if DC function contributed to disease severity. It was found that a deficiency of the antigen-reporting function of DCs and lowered levels of chemicals known as interferons released by them were related to severe symptoms. A decrease in both these functions resulted in higher amounts of virus in the blood (viral load). What’s more, the researchers also found two factors that affected the virus’s ability to replicate in the host, namely, antigen-reporting DCs and the presence of antibodies against the virus. Anomalies in these functions could hamper viral clearance, enabling it to stay in the body longer than expected, whereas a high ability of these immune functions suppresses viral replication and yields prompt viral clearance.

    Components of immune signalling that directly affect the outcome of COVID-19 infection were revealed in this study. “ Our mathematical model predicted the persistent DC reduction and showed that certain patients with severe and even mild symptoms could not effectively eliminate the virus and could potentially develop long COVID,” concludes the duo. A better understanding of these immune responses could help shape the prognosis of and therapeutic interventions against COVID-19.

    Background
    Dendritic cells and the immune system: Dendritic cells (DCs) are part of the body’s innate immune system and are present in areas that come in close contact with pathogens such as the skin, respiratory tract, and gastrointestinal tract. When these tissues are infected, the DCs collate information about the pathogen and display it. DCs are now activated and transform into antigen-presenting cells (APCs). APCs then migrate to the lymph nodes where T cells reside to report this information. The T cells then migrate to and kill the invading pathogens. DCs also play a role in inflammation, a protective mechanism of the body, by releasing interferons. Interferons are chemical messengers that warn neighboring cells of a viral infection.

    It is known that although the numbers of DCs do not change with age, their function is impaired. Since older patients have a higher proclivity for developing severe COVID-19, the patterns of DC function in severe infection were thus investigated by the computer simulation experiments.

    Okayama University

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  • OPEC announces the biggest cut to oil production since the start of the pandemic | CNN Business

    OPEC announces the biggest cut to oil production since the start of the pandemic | CNN Business


    London
    CNN Business
     — 

    OPEC+ said Wednesday that it will slash oil production by 2 million barrels per day, the biggest cut since the start of the pandemic, in a move that threatens to push gasoline prices higher just weeks before US midterm elections.

    The group of major oil producers, which includes Saudi Arabia and Russia, announced the production cut following its first meeting in person since March 2020. The reduction is equivalent to about 2% of global oil demand.

    The price of Brent crude oil rose 1.5% to more than $93 a barrel on the news, adding to gains this week ahead of the gathering of oil ministers. US oil was up 1.7% at $88.

    The Biden administration criticized the OPEC+ decision in a statement on Wednesday, calling it “shortsighted” and saying that it will hurt low and middle-income countries already struggling with elevated energy prices the most.

    The production cuts will start in November, and the Organization of Petroleum Exporting Countries (OPEC) and its allies will meet again in December.

    In a statement, the group said the decision to cut production was made “in light of the uncertainty that surrounds the global economic and oil market outlooks.”

    Global oil prices, which soared in the first half of the year, have since dropped sharply on fears that a global recession will depress demand. Brent crude is down 20% since the end of June. The global benchmark hit a peak of $139 a barrel in March after Russia’s invasion of Ukraine.

    OPEC and its allies, which control more than 40% of global oil production, are hoping to preempt a drop in demand for their barrels from a sharp economic slowdown in China, the United States and Europe.

    Western sanctions on Russian oil are also muddying the waters. Russia’s production has held up better than predicted, with supply being diverted to China and India. But the United States and Europe are now working on ways to implement a G7 agreement to cap the price of Russian crude exports to third countries.

    The oil cartel came under intense pressure from the White House ahead of its meeting in Vienna as President Biden tried to secure lower energy prices for US consumers. Senior Biden administration officials were lobbying their counterparts in Kuwait, Saudi Arabia, and the United Arab Emirates (UAE) to vote against cutting oil production, according to officials.

    The prospect of a production cut was framed as a “total disaster” in draft talking points circulated by the White House to the Treasury Department on Monday, which CNN obtained. “It’s important everyone is aware of just how high the stakes are,” one US official said.

    With just a month to go before the critical midterm elections, US gasoline prices have begun to creep up again, posing a political risk the White House is desperately trying to avoid.

    Rising oil prices could mean inflation remains higher for longer, and add to pressure on the Federal Reserve to hike interest rates even more aggressively.

    But the impact of Wednesday’s cut, while a bullish signal for oil prices, may be limited as many smaller OPEC producers were struggling to meet previous production targets.

    “An announced cut of any volume is unlikely to be fully implemented by all countries, as the group already lags 3 million barrels per day behind its stated production ceiling,” Rystad Energy analyst Jorge Leon said in a note.

    Rystad Energy estimates that the global oil market will be oversupplied between now and the end of the year, dampening the effect of production cuts on prices.

    — Alex Marquardt, Natasha Bertrand, Phil Mattingly, Mark Thompson and Betsy Klein contributed to this report.

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  • A strong fall COVID booster campaign could save 90,000 U.S. lives and avoid more than 936,000 hospitalizations, study finds

    A strong fall COVID booster campaign could save 90,000 U.S. lives and avoid more than 936,000 hospitalizations, study finds

    A strong fall COVID booster campaign could save about 90,000 people living in the U.S. from dying of the virus and avoid more than 936,000 hospitalizations, according to a new study by the Commonwealth Fund.

    As immunity wanes and new variants that can evade protection from early vaccines emerge, surges in hospitalizations and deaths are increasingly likely this fall and winter, the authors wrote. That makes it important that people get the bivalent boosters recently authorized by the Food and Drug Administration and help stop transmission, they wrote.

    Researchers analyzed three scenarios to evaluate the impact of vaccination on reducing fatalities, hospitalizations and medical costs to both the Medicare and Medicaid programs.

    The first measured the outcome if daily vaccination rates remain unchanged from current levels; they have gradually declined since the first wave of the omicron variant. Federal financial support has also not been replenished, amid a perception among many Americans that the pandemic is over and as congressional Republicans oppose legislative efforts to continue the pandemic fight.

    As of Oct. 3, some 68% of the U.S. population has had primary shots, but fewer than half of those have received a booster dose, and only 36% of those aged 50 and older have had a second booster.

    The second and third Commonwealth Fund scenarios looked at outcomes if rates increased by the end of 2022.

    In one scenario, researchers imagined booster uptake would track flu-shot coverage in 2020 to 2021. The other scenario assumed 80% of eligible individuals 5 and older get a booster by the end of 2022.


    Source: Commonwealth Fund

    The data found that more than 75,000 deaths could be prevented along with more than 745,000 hospitalizations if coverage reaches similar levels to 2021 to 2022 flu vaccination. The best scenario would save $56 billion in direct medical costs over the course of the next six months.

    “Stratifying by insurance type, we found direct medical costs would be reduced by $11 billion for Medicare alone under scenario 1 and $13 billion under scenario 2,” the authors wrote. “An additional $3.5 to $4.5 billion in savings would accrue to Medicaid. Even if the federal government paid all vaccination costs, accelerated campaigns would generate more than $10 billion in net savings from federal programs like Medicare and Medicaid.”

    The study comes as U.S. known cases of COVID are continuing to ease and now stand at their lowest level since late April, although the true tally is likely higher given how many people are testing at home, with data not being collected.

    The daily average for new cases stood at 44,484 on Tuesday, according to a New York Times tracker, down 22% from two weeks ago. Cases are rising in most northeastern states by 10% of more, while cases in the are rising in the western states Montana, Washington and Oregon.

    The daily average for hospitalizations was down 12% at 27,334, while the daily average for deaths is down 8% to 393. 

    The new bivalent vaccine might be the first step in developing annual Covid shots, which could follow a similar process to the one used to update flu vaccines every year. Here’s what that process looks like, and why applying it to Covid could be challenging. Illustration: Ryan Trefes

    Coronavirus Update: MarketWatch’s daily roundup has been curating and reporting all the latest developments every weekday since the coronavirus pandemic began

    Other COVID-19 news you should know about:

    • Long COVID, a condition that can encompass symptoms such as respiratory distress, cough, “brain fog,” fatigue and malaise that last 12 weeks or longer after initial infection, is becoming a long-term challenge as both employers and workers navigate an ever-mutating virus, according to Liz Seegert, writing for NextAvenue.org. The Centers for Disease Control and Prevention found that one in five COVID survivors younger than 65 experienced at least one incident that might be related to previous COVID-19 infection. Among those 65 and older, the rate was one in four. Their data also show that nearly three times as many people age 50 to 59 currently have long COVID than those 80 or older.

    • A retired judge opened a public inquiry on Tuesday into how Britain handled the coronavirus pandemic, saying bereaved families and those who suffered would be at the heart of the proceedings, the Associated Press reported. Former Court of Appeal judge Heather Hallett said the inquiry would investigate the U.K.’s preparedness for a pandemic, how the government responded, and whether the “level of loss was inevitable or whether things could have been done better.”

    With each mutation, the Covid-19 virus is becoming more transmissible. WSJ’s Daniela Hernandez breaks down the science of how Covid variants are getting better at infecting and spreading. Illustration: Rami Abukalam

    • Health experts are keeping an eye on new versions of the BA.5 omicron subvariant amid concerns those virus versions can evade the drugs developed to fight COVID, Salon reported. Of particular concern are two named BQ.1 and BQ.1.1, along with BA.2.75.2, which is spreading in Singapore, India and parts of Europe. Then there’s XBB, which some research suggest is the most antibody-evasive strain tested so far. The World Health Organization said in its weekly update on the virus that BA.5 descendent lineages continued to be dominant in the latest week, accounting for 80.8% of sequences shared through a global database. It also noted “increased diversity” within omicron and its lineages.

    • Eiger BioPharmaecuticals Inc.
    EIGR,
    -5.01%

    said Wednesday it will not pursue emergency authorization of its experimental treatment for mild and moderate COVID-19 infections. It had asked the Food and Drug Administration to consider an EUA application based on data from the Together trial, a Phase 3 study that has assessed 11 possible treatments for COVID-19 that is being conducted in Brazil and Canada. Eiger said the FDA instead recommended the company consider running its own pivotal trial for peginterferon lambda that would support full approval of the drug.

    Here’s what the numbers say:

    The global tally of confirmed cases of COVID-19 topped 619.2 million on Wednesday, while the death toll rose above 6.55 million, according to data aggregated by Johns Hopkins University.

    The U.S. leads the world with 96.5 million cases and 1,060,446 fatalities.

    The Centers for Disease Control and Prevention’s tracker shows that 225.3 million people living in the U.S., equal to 67.9% of the total population, are fully vaccinated, meaning they have had their primary shots. Just 109.9 million have had a booster, equal to 48.8% of the vaccinated population, and 23.9 million of those who are eligible for a second booster have had one, equal to 36.6% of those who received a first booster.

    Some 7.6 million people have had a shot of the new bivalent booster that targets the new omicron subvariants that have become dominant around the world.

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