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Tag: Humans

  • A new test for AI labs: Are you even trying to make money? | TechCrunch

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    We’re in a unique moment for AI companies building their own foundation model.

    First, there is a whole generation of industry veterans who made their name at major tech companies and are now going solo. You also have legendary researchers with immense experience but ambiguous commercial aspirations. There’s a clear chance that at least some of these new labs will become OpenAI-sized behemoths, but there’s also room for them to putter around doing interesting research without worrying too much about commercialization.

    The end result? It’s getting hard to tell who is actually trying to make money. 

    To make things simpler, I’m proposing a kind of sliding scale for any company making a foundation model. It’s a five-level scale where it doesn’t matter if you’re actually making money – only if you’re trying to. The idea here is to measure ambition, not success. 

    Think of it in these terms: 

    • Level 5: We are already making millions of dollars every day, thank you very much. 
    • Level 4: We have a detailed multi-stage plan to become the richest human beings on Earth. 
    • Level 3: We have many promising product ideas, which will be revealed in the fullness of time. 
    • Level 2: We have the outlines of a concept of a plan. 
    • Level 1: True wealth is when you love yourself. 

    The big names are all at Level 5: OpenAI, Anthropic, Gemini, and so on. The scale gets more interesting with the new generation of labs launching now, with big dreams but ambitions that can be harder to read. 

    Crucially, the people involved in these labs can generally choose whatever level they want. There’s so much money in AI right now that no one is going to interrogate them for a business plan. Even if the lab is just a research project, investors will count themselves happy to be involved. If you aren’t particularly motivated to become a billionaire, you might well live a happier life at Level 2 than at Level 5. 

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    The problems arise because it isn’t always clear where an AI lab lands on the scale — and a lot of the AI industry’s current drama comes from that confusion. Much of the anxiety over OpenAI’s conversion from a non-profit came because the lab spent years at Level 1, then jumped to Level 5 almost overnight. On the other side, you might argue that Meta’s early AI research was firmly at Level 2, when what the company really wanted was Level 4. 

    With that in mind, here’s a quick rundown of four of the biggest contemporary AI labs, and how they measure up on the scale. 

    Humans& 

    Humans& was the big AI news this week, and part of the inspiration for coming up with this whole scale. The founders have a compelling pitch for the next generation of AI models, with scaling laws giving way to an emphasis on communication and coordination tools.  

    But for all the glowing press, Humans& has been coy about how that would translate into actual monetizable products. It seems it does want to build products; the team just won’t commit to anything specific. The most they’ve said is that they will be building some kind of AI workplace tool, replacing products like Slack, Jira and Google Docs but also redefining how these other tools work at a fundamental level. Workplace software for a post-software workplace! 

    It’s my job to know what this stuff means, and I’m still pretty confused about that last part. But it is just specific enough that I think we can put them at Level 3. 

    Thinking Machines Lab 

    This is a very hard one to rate! Generally, if you have a former CTO and project lead for ChatGPT raising a $2 billion seed round, you have to assume there is a pretty specific roadmap. Mira Murati does not strike me as someone who jumps in without a plan, so coming into 2026, I would have felt good putting TML at Level 4. 

    But then the last two weeks happened. The departure of CTO and co-founder Barret Zoph has gotten most of the headlines, due in part to the special circumstances involved. But at least five other employees left with Zoph, many citing concerns about the direction of the company. Just one year in, nearly half the executives on TML’s founding team are no longer working there. One way to read events is that they thought they had a solid plan to become a world-class AI lab, only to find the plan wasn’t as solid as they thought. Or in terms of the scale, they wanted a Level 4 lab but realized they were at Level 2 or 3. 

    There still isn’t quite enough evidence to justify a downgrade, but it’s getting close. 

    World Labs 

    Fei-Fei Li is one of the most respected names in AI research, best known for establishing the ImageNet challenge that kickstarted contemporary deep learning techniques. She currently holds a Sequoia-endowed chair at Stanford, where she co-directs two different AI labs. I won’t bore you by going through all the different honors and academy positions, but it’s enough to say that if she wanted, she could spend the rest of her life just receiving awards and being told how great she is. Her book is pretty good too! 

    So in 2024, when Li announced she had raised $230 million for a spatial AI company called World Labs, you might think we were operating at Level 2 or lower. 

    But that was over a year ago, which is a long time in the AI world. Since then, World Labs has shipped both a full world-generating model and a commercialized product built on top of it. Over the same period, we’ve seen real signs of demand for world-modeling from both video game and special effects industries — and none of the major labs have built anything that can compete. The result looks an awful lot like a Level 4 company, perhaps soon to graduate to Level 5.

    Safe Superintelligence (SSI) 

    Founded by former OpenAI chief scientist Ilya Sutskever, Safe Superintelligence (or SSI) seems like a classic example of a Level 1 startup. Sutskever has gone to great lengths to keep SSI insulated from commercial pressures, to the point of turning down an attempted acquisition from Meta. There are no product cycles and, aside from the still-baking superintelligent foundation model, there doesn’t seem to be any product at all. With this pitch, he raised $3 billion! Sutskever has always been more interested in the science of AI than the business, and every indication is that this is a genuinely scientific project at heart.  

    That said, the AI world moves fast — and it would be foolish to count SSI out of the commercial realm entirely. On his recent Dwarkesh appearance, Sutskever gave two reasons why SSI might pivot, either “if timelines turned out to be long, which they might” or because “there is a lot of value in the best and most powerful AI being out there impacting the world.” In other words, if the research either goes very well or very badly, we might see SSI jump up a few levels in a hurry. 

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    Russell Brandom

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  • How civilizations lose their spark—and how we might keep ours

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    The feeling will be familiar to many who have visited the great cities of history: I had come to Athens for the first time and made a pilgrimage to its democratic Assembly, Plato’s Academy, and Aristotle’s Lyceum. And it left me with a sense of profound sadness. Here were the scenes of some of the most extraordinary moments in human history, and all that was left was rubble, garbage, and dog waste. Instead of bustling creativity, there was silence, interrupted only by the odd intoxicated passerby.

    To be sure, I also experienced spectacular beauty in Athens, such as the grand monuments on the Acropolis. But even that was a museum to bygone glory. This used to be the place around which the world revolved, and now it’s a collection of patched-together columns, stone blocks and shards with plaques telling us that it used to be impressive.

    This must be what Percy Shelley, a great admirer of ancient Greece, reflected upon when he wrote about the crumbled monument to Ozymandias, king of kings: “‘Look on my works, ye Mighty, and despair!’ / Nothing beside remains. Round the decay / Of that colossal wreck, boundless and bare / The lone and level sands stretch far away.”

    This encounter with the transience of great civilizations set my mind racing. What made it possible for them to rise so spectacularly, and why did they decline so thoroughly? It forced me to consider whether travelers will one day visit our proud landmarks and plazas and think about how our civilization lost its way and became so sluggish and stationary. 

     

    This is a precarious time to write about history’s golden ages. Ours is an era of authoritarian and populist revival, with savage dictators trying to extinguish neighbouring democracies, when the fear of inevitable decline seems more prevalent than belief in progress. 

    The American legal scholar Harold Berman compared his history of the rise of Western law to a drowning man who sees his whole life flash before him, perhaps in an unconscious effort to find something within his own experiences to help him escape his impending doom. We are not yet drowning, but drawing on historical human experience can be a useful way to avoid ending up in a bad situation. It might even help us to keep our vessels seaworthy. 

    It is said that we should study history to avoid repeating its mistakes, and that is all very well. But our ancestors were not just capable of mistakes. Human history is a long list of depravations and horrors, but it is also the source of the knowledge, institutions, and technologies that in the last few centuries have set most of humanity free from such horrors for the first time. The historical record shows what mankind is capable of, in terms of exploration, imagination, and innovation. This in itself is an important reason to study it, to broaden our mental horizon of what is possible. 

    In my new book, Peak Human: What We Can Learn from the Rise and Fall of Golden Ages, I explore seven of the world’s great civilizations: ancient Athens, the Roman Republic and early Roman Empire, the Abbasid Caliphate, Song China, Renaissance Italy, the Dutch Republic, and the Anglosphere. Each of them exemplifies what I think of as a golden age: a period with a large number of innovations that revolutionize many fields and sectors in a short period of time. 

    A golden age is associated with a culture of optimism, which encourages people to explore new knowledge, experiment with new methods and technologies, and exchange the results with others. Its characteristics are cultural creativity, scientific discoveries, technological achievements, and economic growth that stand out compared to what came before and after and compared to other contemporary cultures. Its result is a high average standard of living, which is usually the envy of others and often also of its heirs. 

    Peak Human could have been a much longer book, exploring many other cultures, because golden ages are dependent not on geography, ethnicity, or religion but on what we make of these circumstances. These cultures just happened to excel in the era in which they, for some reason or another, began to interpret or emphasize a particular part of their beliefs and traditions to make them more open to surprises—unconventional ideas and methods imported by merchants and migrants, dreamed up by eccentrics, or stumbled upon by someone fortunate. 

    There are certain important preconditions for this progress. The basic raw materials are a wide variety of ideas and methods to learn from and to combine in new ways. It therefore takes a certain population density to create progress, and urban conglomerations are often particularly creative. Being open to the contributions of other civilizations is the quickest way of making use of more brains, which is why these golden ages often appeared at the crossroads of different cultures and in every instance benefited greatly from the inspiration brought about by international trade, travel, and migration. They were often maritime cultures, always on the lookout for new discoveries. Distance is the “number one enemy of civilization,” as the French historian Fernand Braudel understood so well. 

    To make use of these raw materials, it takes a relatively inclusive society. Citizens have to be free to experiment and innovate, without being subjected to the whims of feudal lords, centralized governments, or ravaging armies. This takes peace, rule of law, and secure property rights. Most importantly, there has to be an absence of orthodoxies imposed from the top about what to believe, think, and say; how to live; and what to do. If we limit the realm of the acceptable to what we already know and are comfortable with, we will be stuck with it, and we will deserve the stagnation we get. If we want more knowledge, wealth, and technological capacity, we have to cut misfits and troublemakers some slack. 

    Institutions that are built for discovery, innovation, and adaptation have profound effects on science, culture, economy, and warfare. It is not easy to sustain such institutions for a long time. The most depressing aspect of studying golden ages is that they don’t last. You don’t have to wait 2,300 years to go back to Athens. There are many stories about people visiting centers of progress just a few decades later and finding that it’s all over. It’s the same place, the same traditions, and the same people, but that irreplaceable spark has disappeared. 

    The California historian Jack Goldstone calls these episodes of temporary growth “efflorescences.” That is really another word for an anti-crisis: Just as a crisis is a sudden and unexpected downturn in indicators of human well-being, an efflorescence is a sharp, unexpected upturn. 

    Goldstone argues that most societies have experienced such efflorescences, and that these usually set new patterns of thought, political organization, and economic life for many generations. This is a corrective to the common notion that humankind has a long history of stagnation and then suddenly experiences progress. History is full of growth and progress; it is just that they were always periodic and efflorescent rather than self-sustaining and accelerating. In other words: They don’t last.

    Civilizations in every era have tried to break away from the shackles of oppression and scarcity, but increasingly they faced opposite forces, which sooner or later dragged them back to Earth. Elites who have benefited from innovation want to kick away the ladder behind them; groups threatened by change try to fossilize culture into an orthodoxy; and aggressive neighbours, attracted to the wealth of nearby achievers, try to kill the goose to steal its golden eggs. 

    Why would intellectual, economic, and political elites accept a system that keeps delivering surprises and innovations? Yes, it might provide their society with more resources, but at the risk of upending a status quo that made them powerful to begin with. Often such institutions came about as a result of revolutionary upheaval or emerged unintentionally because they happened to provide important solutions in difficult situations or at a time of fierce competition against rivals. 

    But sooner or later, most elites regain their composure and begin to reimpose orthodoxies and stamp out the potential for unpredictability. The great economic historian Joel Mokyr calls this Cardwell’s Law, after the technology historian D. S. L. Cardwell, who observed that most societies remain technologically creative for only a short period. 

    The perceived self-interest of incumbents who have much to lose from change goes a long way to explaining why episodes of creativity and growth are terminated. But such groups are always there, always eager to stop the future in its tracks. Why do their reactions prevail in some places and moments but not in others? Many factors are at play, but there is one psychological factor that reinforces all of them. 

    “What is civilization’s worst enemy?” asked the art historian Kenneth Clark. He answered: “First of all fear—fear of war, fear of invasion, fear of plague and famine, that make it simply not worthwhile constructing things, or planting trees or even planting next year’s crop. And fear of the supernatural, which means that you daren’t question anything or change anything.”

     

    We humans have two basic settings: We are traders, and we are tribalists. Early humans prospered (relatively) because they ventured out to explore, experiment, and exchange, to discover new places, partners, and knowledge. But sometimes they only survived their adventures because they were also acutely sensitive to risks and instantly reacted to a potential threat by fighting or fleeing back to the familiar, their cave and their tribe. We need both the adventurous and the risk-sensitive aspects of our personality. But since Homo sapiens emerged over hundreds of thousands of years in a world more dangerous than today’s, our “spider sense” is over-sensitive to threats: It often misfires and is easily manipulated by those who want to divide and conquer. 

    As I documented in my book Open: The Story of Human Progress, this anxious aspect has remained a central part of our nature, even after we left the savannah for a safer world. When we feel threatened as a community by, say, neighbouring armies, pandemics, or recessions, there is often a societal fight-or-flight instinct, causing us to hunt for scapegoats and flee behind physical and intellectual walls, even though complex threats might call for learning and creativity rather than simply avoidance or attack. 

    Again and again, we see civilizations prosper when they embrace trade and experiments but decline when they lose cultural self-confidence. When under threat, we often seek stability and predictability, shutting out that which is different and unpredictable. Unfortunately, this often makes the fear of disaster self-fulfilling, since those barriers limit access to other possibilities and restrict the adaptation and innovation that could have helped us deal with the threat. The problem with paralyzing fear is that it has a tendency to paralyze. 

    I wouldn’t go so far as to say that we have nothing to fear but fear itself. That sounds a bit like underestimating armed raiders and bubonic plague. But it is certainly true that an insular, suppressive angst deprives us of the tools we need to take on the problems we face. Outsiders can kill and destroy, but they can’t kill curiosity and creativity. Only we can do that to ourselves. 

    History often repeats because human nature does. All of the golden ages ended, except one—the one that we are in now. But “history,” said the American journalist Norman Cousins, “is a vast early warning system.” We still know how to swim, but that doesn’t happen automatically; it takes a conscious effort. For that reason, repeating history’s swimming lessons once in a while is helpful. 

    To situate my argument in the context of current culture wars, I object both to the relativist idea that all cultures are equal and to the idea that there is a hierarchy of two opposing and clashing cultures—civilization vs. barbarians (often associated with European Judeo-Christian culture vs. the rest). 

    Yes, some cultures are better than others. Denying that is, as pointed out by the physicist David Deutsch, “denying that the future state of one’s own culture can be better than the present.” It implies that chattel slavery and human rights are equally good (or bad). Some cultures are better than others because they provide institutions for positive-sum games instead of zero-sum; they create liberties and opportunities rather than oppression and destruction. 

    But no, we are not talking here about the inherent traits of two opposite and clashing civilizations. Among the seven golden ages featured here, we meet pagans, Muslims, Confucians, Catholics, Calvinists, Anglicans, and secular civilizations. Those who were seen as barbarians in one era became world leaders in science and technology in the next, and then roles reversed again. They excelled at a time in which their culture was open to the contributions of other civilizations, and so gained access to more brains. 

    This is why both the nationalist right and the woke left are hopelessly unhistorical in their crusades against cultural hotchpotch: Civilizations are not monoliths with inherent traits but complex, growing things defined by how they engage with, adopt, and adapt (appropriate, if you like) what they find elsewhere. It’s the connections and combinations that make them what they are. 

    The battle between freedom and coercion, and between reason and superstition, is not a clash of civilizations. It is a clash within every civilization, and at some level within each one of us. Every culture, country, and government is capable of decency and creativity as well as ignorance and jawdropping barbarianism. That is why “golden” should be understood as much in relationship to what you could otherwise have been as it should be understood as making a comparison with others. It is of course not just down to sheer will, but you and I have it within ourselves to help make our particular place on earth decent and creative rather than the opposite. 

    It is important to grapple with the question “golden ages for whom?” All of the civilizations I describe in this book practised slavery, all of them denied women basic rights, and all took great delight in exterminating neighbouring populations to the last man, woman, and child. 

    Whenever I am tempted to look back at these ages and dream about how amazing it would have been to be alive then—to debate philosophy in the Athenian Lyceum or Baghdad’s House of Wisdom, to discuss political strategy with Cicero or the Song emperor, or to be present at the creation of the Pantheon, The Last Supper, or the printing press—I remind myself that I wouldn’t have come near those places. I would have been a destitute peasant, struggling desperately to keep my family safe from hunger and raiders for another season. 

    If I were one of the lucky ones, that is. As the classicist Mary Beard has remarked, when people say they admire the Roman Empire, they always assume they would have been the emperor or a senator (a few hundred people) and never the enslaved masses in mines, plantations, and other people’s households (a few million). 

    Recorded history is the work of a tiny literate elite, and for most people, in most eras, life was nasty, brutish, and short. In fact, that went for the elites too. No matter how powerful they were, everything could be lost in an instant if they had the misfortune to displease a capricious ruler, and even he had little chance against, say, a bacterial infection or a barbarian invasion. Remember that every time history books record that a city was “sacked,” it means that thousands of civilians were raped, mutilated, and disembowelled. This also tells us something about what mankind is capable of. 

    But history is more than a crime scene. It is also the place where ideas were developed that helped humanity to identify the crimes and overcome them. If we discard all the achievements of those who came before us because they weren’t sufficiently enlightened and decent (they weren’t), we will eventually lose the capacity to discern what is enlightened and decent. Because that very language and moral sense emerged out of their struggles. 

    If you discover something inspiring and useful there, in the overgrown ruins of the past, that can be salvaged to help ensure that our civilization does not just become one in the long list of Goldstone’s temporary efflorescenses, let’s fight for it, shall we? As Goethe once told us, you cannot inherit a tradition from your parents; you have to earn it.

    Johan Norberg is the author of Peak Human: What We Can Learn from the Rise and Fall of Golden Ages, from which this article is adapted by permission of Atlantic Books.

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    Johan Norberg

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  • Unbelievable facts

    Unbelievable facts

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    Human evolution tackles similar challenges in distinct ways. Early native peoples adapted to high…

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  • Why Is Yawning Contagious

    Why Is Yawning Contagious

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    Someone starts and it spreads…why is yawning contagious?

    Whether at work, school or a dinner, once someone yawns, it is over…more yawning, then someone gets up and the fun bubble has popped.  But what happens? Why is yawning contagious? In 400 B.C., Hippocrates thought yawning removed bad air from the lungs before a fever. In the 17th and 18th century, doctors believed yawning increased oxygen in the blood, blood pressure, heart rate and blood flow itself. So it made sense you would want to follow the example…but what makes the body do it involuntary?

    In the past, people have had many hypotheses. In the last century, consensus moved toward the idea that yawning cools down the brain, so when ambient conditions and temperature of the brain itself increase, yawning episodes increase.

    Typically a yawn lasts four to seven seconds and happens in fits of two or three. It involves the following steps:

    • A long inhale (breathing in) using your nose and then mouth.
    • A brief episode of powerful muscle stretching around your mouth and throat.
    • A rapid exhale (breathing out) using your mouth with muscle tension release.

    Yawning is mostly involuntary, meaning you don’t have control over it. And most scientists consider it a reflex.

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    And yawning occurs in just about every species. It happens when an animal is tired. It can be used as a threat display in some species. Yawning can occur during times of social conflict and stress, something researchers call a displacement behavior.  So it isn’t just a human reaction, it is the animal kingdom also….so why does it happen and why is so darn contagious?

    Yawning happens in many animal species – and seems to pass from one to another. Robert Gramner on Unsplash, CC BY

    Yawning is a common but perplexing human function. Scientists have several theories but nothing concrete. Common triggers of yawning include tiredness, boredom, waking up and stress.  A current theory about yawning is the arousal hypothesis states yawning activates your brain. This theory is tied to the fact tiredness and boredom tend to trigger yawning the most.

    Seeing or hearing other people yawn can also cause you to yawn. The wide-open mouth can be contagious, especially in social species such as humans, chimpanzees, bonobos, macaques and wolves. In addition, research on humans tell us people who are more empathetic tend to be more susceptible to contagious yawning. When you see someone else yawn, the networks in your brain responsible for empathy and social skills are activated.

    Is yawning contagious for dogs also. In U.K. biologists tested for contagious yawning between people and man’s best friend. Although 5 of the 19 dogs studied did yawn in response to an unfamiliar person’s yawn, the researchers couldn’t prove the yawns were contagious.  But, cognitive and behavioral scientists at the University of Tokyo once again tested contagious yawning in canines while controlling for stress. This time researchers found dogs were more likely to yawn in response to a familiar person. They concluded dogs can “catch” a yawn from humans and yawning is a social rather than an stress-based behavior.

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    University of Nebraska psychologists looked at contagious yawning in shelter dogs. They found some dogs yawned when exposed to human yawning and had elevated cortisol levels, a proxy for stress. Levels of the cortisol stress hormone did not rise in dogs who didn’t yawn in response to a human yawn. This finding suggests some dogs find human yawning stressful and others do not. More research is needed to evaluate this aspect of the human-dog relationship.The ConversationThe jury’s still out on the true why of yawning. But when it comes to inter-species yawning, collect your own anecdotal data. Try an experiment at home, yawn and see if your pet yawns back.

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    Anthony Washington

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  • The Halo TV show making the humans the villains completely misses the point

    The Halo TV show making the humans the villains completely misses the point

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    It’s become increasingly clear that the Halo TV show has a villain problem. This may seem impossible for a series that’s supposed to be about a hostile race of aliens led by liars who exploit religious fanaticism, but instead the show can’t stop focusing on human bickering, bizarrely relegating the galaxy-conquering aliens to an afterthought for both the characters in the show and the audience.

    I could talk about how Halo’s centering of humans as the bad guys behind every plot cheapens one of the few fascinating moral complexities of the Halo games and books — that the Spartans were built for fundamentally inhumane treatment of rebel fighters and then accidentally found justification in a surprise alien invasion. But it’s more fair and even more damning to talk about all of this on the Halo TV show’s own terms. And on those terms, I simply have no fucking idea why there are even aliens in this show to begin with.

    In an effort to underline the badness of humanity, Halo has completely sidelined the Covenant, throwing the entire show off course and spinning wildly into space. Even the Covenant’s grand invasion of Reach in the show is just another human plot, one of a thousand ways the TV show wants to prove that the human bureaucrats are evil, something we’ve known since the earliest moments of the show’s first season.

    But all this emphasis on humanity’s sins begs a critical question: Almost two full seasons into Halo, what point is it trying to make, exactly? Season 2’s seventh episode, “Thermopylae,” seems to offer some attempt at answering that question, when Makee (Charlie Murphy) pleads with Chief to stop helping humanity so that the two of them can settle Halo on their own and make it a paradise, rather than letting either side use it as a civilization-destroying weapon. Setting aside the silliness that is this version of Halo being so constantly tempted to recast Master Chief (Pablo Schreiber) as the lead of a domestic drama, Makee’s statement still leaves a gap in our understanding of what this show is doing. If the point is “war makes monsters of us all,” then shouldn’t we see that equally in both the human and Covenant factions? And even more pressingly, why won’t anyone acknowledge that the Covenant are the ones who threatened extinction first and based their whole galactic conquest on the Prophets’ lie about a Great Journey that would take them from the galaxy?

    Photo: Adrienn Szabo/Paramount Plus

    We’re subjected to half a dozen scenes each episode of humanity’s reckless and evil leaders making civilization-shaping choices — particularly the ongoing machinations of Admiral Margaret Parangosky (Shabana Azmi), one of the worst and least compelling characters in recent TV memory, thanks to her consistently baffling decisions and seemingly lack of strategy and communication. (Put simply: She’s here to antagonize every other character, with no real character of her own.) Meanwhile we only get to see the Covenant’s side from the point of view of Makee and the criminally underdeveloped Arbiter. Sure, we hear them say that the Prophets might be full of shit and that the Great Journey might be a lie, but it remains a complete mystery why the alien’s genuinely compelling similarity to Earth’s own corrupt and lying authorities is drawn with such a faint line. Perhaps drawing those connections more clearly would help us make sense of why Master Chief has fought more humans in Halo season 2 than he has Covenant.

    Despite the moment-to-moment conflict rarely making sense, or seeming to lead anywhere, it hasn’t stopped the show from introducing more plot threads or drip-feeding longtime series fans with new bits of recognizable lore. For instance, this latest episode gave us our most meaningful look yet at the Forerunners, though they haven’t been named quite yet. It also hinted at yet another alien faction that could soon arrive, but we’ll have to wait and see if that thread goes anywhere.

    All these new introductions do little to lessen the feeling of narrative cheapness that surrounds Halo, however. As more ideas and plots get introduced, it only serves to underline how little sense any of this really makes. Sure, we know the Covenant are knocking on humanity’s front door, but the sudden diversion of every character in the show now converging on a need to capture “the Halo,” as they keep calling it, feels like it came out of nowhere. Which is a pretty astounding feat of messy storytelling considering it’s the object the entire franchise is named after.

    Halo season 2 is now streaming on Paramount Plus. The season finale will be released on Thursday, March 21.

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    Austen Goslin

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  • We Got Lucky With the Mystery Dog Illness

    We Got Lucky With the Mystery Dog Illness

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    In late July 1980, a five-month-old Doberman pinscher puppy in Washington, D.C., started throwing up blood. It died the next day at an animal hospital, one of many pets that suffered that year from a new illness, parvovirus. “This is the worst disease I’ve ever seen in dogs,” a local veterinarian told The Washington Post, in an article describing the regional outbreak. It killed so fast that it left pet owners in disbelief, he said.

    The world was in the middle of a canine pandemic. The parvovirus, which was first recognized in 1978, can live for months outside the body, spreading not just from animal to animal but through feces, sneaking into the yards of dog owners via a bit of excrement stuck to the bottom of a person’s shoe. It quickly traveled across countries and continents, infecting thousands and possibly millions of dogs in the late ’70s and early ’80s. Essentially every dog alive at the time caught it, Colin Parrish, a virology professor at Cornell University’s College of Veterinary Medicine, told me. And untold numbers  died: A single Associated Press report from August 1980 mentions the city of Chicago losing 300 dogs by July of that year, and South Carolina losing more than 700 in just two months.

    A vaccine was quickly developed, but with doses in short supply, the outbreaks dragged on for years. Today, puppies are routinely vaccinated for parvovirus, and the 1978 canine pandemic has faded from public consciousness. Since then, no outbreak has unfolded on that scale, even as dogs have become more integrated into American households. Few people stay up at night worrying about what might happen if a new and devastating disease did appear. Yet, for a moment at the end of last year, it seemed like one might have.

    In late 2023, veterinarians started noticing something odd. They’d seen an uptick in cases of dogs sick with respiratory symptoms responding poorly to antibiotics. Some would develop severe pneumonia quickly and die. Soon, cases of this suspected illness started popping up in states across the country. Around Thanksgiving, media reports began warning dog owners about a “mystery dog illness” spreading nationwide.

    Many experts now suggest that there probably was no “mystery dog illness.” More likely, some mix of previously known illnesses were surging around the same time. Still, the case is not entirely closed, and the prospect of a deadly new disease has left dog owners fearful and jumpy: How much should they worry? Could that seemingly normal cough in the family pet actually be something much more dangerous?

    And if a new disease had started a modern dog pandemic, the world’s first in almost 50 years, what would have happened next is not entirely clear. Unlike humans and livestock, companion animals do not have sophisticated, coordinated infrastructure dedicated to monitoring and managing their diseases. The technology and science might exist to fight a dog pandemic, but any response would depend on what kind of illness we found ourselves dealing with—and whether it could infect humans as well.

    Because dogs don’t interact with one another as much as humans do, dog transmission networks are different from ours. They see one another on walks, in day cares, or in dog parks. Some might travel between states or even between countries, but many just stay in their backyard. Their cloistered networks make it hard for some viruses to move among them. In 2015 and 2016, outbreaks of a nasty canine flu called H3N2, which was traced to a single introduction in the United States from South Korea, never reached full pandemic status. “I just remember seeing so many of these pretty sick dogs, like every day,” Steve Valeika, a veterinarian and infectious-disease specialist in North Carolina, told me. “And then it just stopped.” Most of his cases were from one boarding facility.

    A disease such as parvo, which can spread without direct contact, has a better chance of circulating widely. But even then, authorities could respond quickly, maybe even quicker than in 1978. The same mRNA tools that led to the speedy development of a COVID vaccine for humans could be used in a dog pandemic; the ability to test for dog diseases has improved since parvovirus. Information travels that much faster over the internet.

    Still, as companion animals, dogs and cats fall into an awkward space between systems. “There is no CDC for dogs,” Valeika said. “It’s all very patchwork.” Typically, animal disease is managed by agricultural agencies—in this country, the USDA. But these groups are more focused on outbreaks in livestock, such as swine flu, which threaten the food supply, the economy, or human safety. If an outbreak were to emerge in companion animals, veterinary associations, local health departments, and other dog-health groups may all pitch in to help manage it.

    The dairy and pig industries, for example, are far more coordinated. “If they said, ‘We need to get all the players together to talk about a new emerging disease issue on pigs,’ that’d be easy. They’d know who to call, and they’d be on the phone that afternoon,” Scott Weese, professor in veterinary infectious diseases at the University of Guelph, in Canada, explains. Organizing a conference call like that on the topic of a dog disease would be trickier, especially in a big country like the United States. And the USDA isn’t designed around pets, although “it’s not that they don’t care or don’t try,” he said. (The USDA did not respond to a request for comment.) No one is formally surveilling for dog disease in the way government agencies and other groups monitor for human outbreaks. At base, monitoring requires testing, which is expensive and might not change a vet’s treatment plan. “How many people want to spend $250 to get their swab tested?” Parrish asked.

    Dogs aren’t human. But they are close to humans, and it is easy to imagine that, in a dog pandemic, owners would go to great lengths to keep their pets safe. Their closeness to us, in this way, could help protect them. It also poses its own risk: If a quickly spreading dog disease jumped to humans, a different machinery would grind into gear.

    If humans could be vulnerable and certainly if they were getting sick, then the CDC would get involved. “Public health usually takes the lead on anything where we’ve got that human and animal side,” Weese told me. These groups are better funded, are better staffed, and have more expertise—but their priority is us, not our pets. The uncomfortable truth about zoonotic disease is that culling, or killing, animals helps limit spread. In 2014, after a health-care worker in Spain contracted Ebola, authorities killed her dog Excalibur as a precaution, despite a petition and protests. When the woman recovered, she was devastated. (“I’ve forgotten about everything except the death of Excalibur,” she later told CNN.) Countries routinely cull thousands of livestock animals when dealing with the spread of deadly diseases. If a new dog-borne pathogen threatened the lives of people, the U.S. would be faced with the choice of killing infected animals or dedicating resources to quarantining them.

    A scenario in which pet owners stand by while their dogs are killed en masse is hard to imagine. People love their pets fiercely, and consider them family; many would push to save their dogs. But even in a scenario where humans were safe, the systems we’ve set up might not be able to keep pets from dying on a disturbing scale. Already, there’s a nationwide shortage of vets; in a dog-health emergency, people would want access to emergency care, and equipment such as ventilators. “I am concerned that we don’t have enough of that to deal with a big pandemic as it relates to pets,” Jane Sykes, a medicine and epidemiology professor at the UC Davis School of Veterinary Medicine and the founder of the International Society for Companion Animal Infectious Diseases, told me.

    Congress has mandated that the CDC, USDA, and Department of the Interior, which oversees wildlife, work on strengthening “federal coordination and collaboration on threats related to diseases that can spread between animals and people,” Colin Basler, the deputy director of CDC’s One Health Office, wrote in an email statement. A new, deadly canine disease would almost certainly leave experts scrambling to respond, in some way. And in that scramble, pet owners could be left in a temporary information vacuum, worrying about the health of their little cold-nosed, four-legged creatures. The specifics of any pandemic story depend on the disease—how fast it moves, how it sickens and kills, and how quickly—but in almost any scenario it’s easy to imagine the moment when someone fears for their pet and doesn’t know what help will come, and how soon.

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    Caroline Mimbs Nyce

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  • WTF Fun Fact 13657 – Humanity's Last Day Together

    WTF Fun Fact 13657 – Humanity's Last Day Together

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    October 31, 2000, was humanity’s last day all humans were together on Earth.

    Since that day, there has always been at least one person in space, marking a continuous human presence off our planet.

    The International Space Station: A New Era

    The event that initiated this ongoing human presence in space was the launch of Expedition 1 to the International Space Station (ISS). The ISS has since been home to astronauts from around the world. It serves as a research laboratory where scientific studies are conducted in microgravity.

    Expedition 1 crew members, William Shepherd (USA), Yuri Gidzenko (Russia), and Sergei Krikalev (Russia), were the pioneers of this new era. They launched aboard a Russian Soyuz rocket and began what has become over two decades of continuous human occupation of the ISS.

    The Significance of October 31, 2000: Humanity’s Last Day

    This date is more than just a historical milestone. It signifies humanity’s leap into a future where living and working in space is a reality.

    The ISS has been instrumental in advancing our understanding of space and science. Research conducted there has led to breakthroughs in medicine, environmental science, and materials engineering. The microgravity environment provides unique conditions for experiments impossible to replicate on Earth.

    Future Missions

    Living aboard the ISS has provided vital information about the effects of long-duration spaceflight on the human body. This knowledge is crucial for planning future missions to the Moon, Mars, and beyond.

    Understanding how to maintain physical and mental health in space is key to the success of these ambitious projects.

    As we look to the future, the legacy of October 31, 2000, continues to influence space policy and aspirations.

    With plans for lunar bases and Mars expeditions, the horizon of human space habitation is expanding. The ISS has laid the groundwork for these future endeavors, proving that humans can live and thrive in the harsh environment of space.

     WTF fun facts

    Source: “Celebrating the 20th Anniversary of the First International Space Station Module” — ISS National Laboratory

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    WTF

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  • Bats Could Hold the Secret to Better, Longer Human Life

    Bats Could Hold the Secret to Better, Longer Human Life

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    In Linfa Wang’s ideal world, all humans would be just a bit more bat-like.

    Wang, a biochemist and zoonotic-disease expert at Duke-NUS Medical School, in Singapore, has no illusions about people flapping about the skies or echolocating to find the best burger in town. The point is “not to live like a bat,” Wang told me, but to take inspiration from their very weird physiology in order to boost the quality, or even the length, of human life. They might not look it, but bats, Wang said, are “the healthiest mammals on Earth.”

    That thought might be tough to square with bats’ recent track record. In the past three decades—from 1994, when Hendra virus jumped to humans, to 2019, when SARS-CoV-2 emerged—at least half a dozen of the most devastating viral epidemics known to have recently leapt into people from wildlife have had their likeliest origins in bats. But bats themselves rarely, if ever, seem to fall ill. Ebola, Nipah, Marburg, and various coronaviruses don’t appear to trouble them; some bats can survive encounters with rabies, which, left untreated in humans, has a near 100 percent fatality rate. “They’ve evolved mechanisms to limit the damage of disease,” says Emma Teeling, a bat biologist at University College Dublin, who collaborates with Wang.

    The creatures’ apparent ability to defy death goes even beyond that. Some nectar-devouring species spend years spiking their blood-sugar levels high enough to send a human into a hyperglycemic coma—and yet, those bats never seem to develop what we’d call diabetes. Others have been documented surviving up to 41 years in the wild—nearly 10 times as long as mammals of their size are generally expected to live—all the while avoiding cancer and fertility dips.

    Wang and Teeling, along with several colleagues, were recently awarded a $13 million grant by the European Research Council to try to better understand the biology behind these batty abilities—and how it might help other creatures. (And they’re certainly not the only ones trying to find out.) Wang’s team, as he likes to cheerfully boast, has already put some of his ideas to the test by genetically engineering a healthier, more disease-tolerant “bat-mouse.” He and his colleagues are still years away from creating any sort of bat person, but they are confident that this line of thinking could one day inform new treatments for humans—to combat diabetes, to temper infectious diseases, maybe even to extend the life span.

    The key to bats’ health seems to be flight, or at least the effects that evolving flight has had on the bat body. Flight, for all its perks, is one of the most energetically taxing transportation options: When bats fly, their metabolism can rev up to 15 to 16 times above its resting state; their heart rate may soar above 1,000 beats per minute; their body temperature can exceed 105 degrees Fahrenheit, effectively plunging the animals into an epic fever state. Put all of that on virtually any other mammal, and their body would likely be overwhelmed by the blaze of extreme inflammation, the toxic by-products of their metabolism effectively rending cells apart.

    To cope with this self-destructive form of locomotion, bats have evolved two essential safeguards. First, they are extraordinarily good at maintaining bodily Zen. Even when pushed into extreme forms of exertion, bat bodies don’t get all that inflamed—maybe in part because they lack some of the molecular machinery that kicks those systems into gear. Which means that bats simply rack up less damage when their bodies get stressed. And for any damage that does occur, bats have a second trick: Their cells appear to be unusually efficient at cleanup and repair, rapidly stitching back together bits of torn-up DNA.

    Those strategies, Wang and Teeling told me, haven’t just made flight a breeze for bats. They also mitigate other types of bodily harm. Cancer tends to unfurl after errors appear in particular parts of our genetic code. And, molecularly speaking, aging is basically what happens to the body as it accumulates a lifetime of cellular wear and tear. In a sense, stress is simply stress: The root causes of these chronic health issues overlap with the greatest taxes of flight. So the solutions that keep a bat body running smoothly in the air can address problems throughout its lifetime. While humans get worse at repairing damage with age, bats’ ability improves, Teeling told me.

    All of this can also help explain why bats are such hospitable hosts for pathogens that can kill us. Many of the most dangerous cases of infectious disease are driven by the body’s overzealous inflammatory response; that reaction can pose a greater threat than any damage that a pathogen itself might do to cells. Many of our defenses are like bombs set off on our home turf—capable of killing invaders, yes, but at great cost to us. Bats have such a high threshold for igniting inflammation that many viruses seem able to inhabit their tissues without setting off that degree of destruction. In laboratory experiments, bats have been dosed with so much virus that their tissues end up chock-full—clocking some 10 million units of Ebola virus per milliliter of serum, or 10 million units of the MERS coronavirus per gram of lung——and researchers were still unable to discern serious problems with the bats’ health. Bats and their viruses have, in effect, struck “an immunological detente,” says Tony Schountz, a bat immunologist at Colorado State University.

    Such astronomical levels of virus aren’t a bat’s preferred state. Bat bodies also happen to be very good at tamping down viral replication up front. Part of the reason seems to be that, in certain bat species’ bodies, parts of their antiviral defense system “are always on,” Wang told me. “I call them ‘battle ready.’” So when a pathogen does appear, it knocks up against a host that is already teeming with powerful proteins, ready-made to block parts of the viral life cycle, hindering the microbe from spinning out of control.

    The catch here is that the viruses have wised up to bats’ tricks—and evolved to be more forceful as they attempt to infiltrate and replicate inside of, and then spread between, those well-defended cells. And that bat-caliber offense can be excessive in a human that lacks the same shields, says Cara Brook, a disease ecologist at the University of Chicago. That might help explain why so many bat viruses hit us so hard.. Couple that show of force with our difficulties reining in our own inflammation, and what might have been a trivial infection for a bat can turn into utter chaos for a person.

    One of Wang’s primary ideas for dealing with this kind of host-pathogen mismatch is to use drugs to make our inflammatory responses a bit more muted—that is, a bit more bat-like. That option is especially intriguing, he told me, because it could also lower the risk of autoimmunity, maybe even forestall aging or certain kinds of chronic metabolic disease. His bat-mouse, which was engineered to express a particular inflammation-suppressing bat gene, is an experiment with that principle, and it seemed to fare better against flu, SARS-CoV-2, even gout crystals.

    But the idea of muffling inflammation isn’t exactly new: Our medical armamentarium has included steroids and other immune-system-modulating drugs for decades. All have their limits and their drawbacks, and a treatment specifically inspired by bats would likely be subject to the same caveats, says Arinjay Banerjee, a virologist and bat immunologist at the University of Saskatchewan. Inflammation, as damaging as it can be, is an essential defense. Any drug that modifies it—especially one taken long-term—must avoid the hurt of too much while skirting the risk of not enough. And ultimately, humans just aren’t bats. Plop a bat’s defense into a human body, and it might not work in the way researchers expect, says Hannah Frank, a bat immunologist at Tulane University. To truly see bat-like benefits in people, chances are, we’d need more than one treatment turning more than one physiological dial, Banerjee told me.

    As much as researchers are learning about bats, the gaps in their knowledge are still huge. What’s observed in one of the more than 1,400 species of bats may not hold true for another. Plus, bat physiology is distinct enough from ours that no one really can precisely say what optimal health for them looks like, Frank told me. Although bats rarely die from their viruses, those infections may be still taking a toll in ways that researchers have yet to appreciate, Brook told me. Bats aren’t the only intriguing virus-carriers, either. Rodents, too, haul around a lot of deadly pathogens without falling sick, as Schountz points out. Nor are they the only mammals that live at extremes. Naked mole rats withstand low-oxygen conditions underground; seals must cope with organ-crushing pressures when they dive. Like flight, those adaptations may have rejiggered immunity in yet untold ways.

    Certainly, though, bats have more to offer us than many people give them credit for. In the aftermath of a Hendra virus outbreak in Australia, years ago, “we even had a politician say, Let’s bomb the bats,” Wang told me. The start of the coronavirus pandemic, too, ignited calls for bat cullings; some animals were even reportedly burned out of roosts. “I still don’t want a bat as a pet,” Wang told me. But if his findings keep panning out, maybe someday people will associate bats less with the diseases we don’t want to get from them, and more with the healthy traits we do.

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    Katherine J. Wu

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  • The Other Group of Viruses That Could Cause the Next Pandemic

    The Other Group of Viruses That Could Cause the Next Pandemic

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    Whether it begins next week, next year, or next decade, another pandemic is on its way. Researchers can’t predict precisely when or how the outbreak might begin. Some 1.6 million viruses are estimated to lurk in the world’s mammalian and avian wildlife, up to half of which could spill into humans; an untold number are attempting exactly that, at this very moment, bumping up against the people hunting, eating, and encroaching on those creatures. (And that’s just viruses: Parasites, fungi, and bacteria represent major infectious dangers too.) The only true certainty in the pandemic forecast is that the next threat will be here sooner than anyone would like.

    But scientists can at least make an educated guess about what might catalyze the next Big One. Three main families of viruses, more than most others, keep scientists up at night: flu viruses, coronaviruses, and paramyxoviruses, in descending order of threat. Together, those groups make up “the trifecta of respiratory death,” Sara Cherry, a virologist at the University of Pennsylvania, told me.

    Flu and coronavirus have a recent track record of trouble: Since 1918, flu viruses have sparked four pandemics, all the while continuing to pester us on a seasonal basis; some scientists worry that another major human outbreak may be brewing now, as multiple H5 flu viruses continue to spread from birds to mammals. The past two decades have also featured three major and deadly coronavirus outbreaks: the original SARS epidemic that began in late 2002; MERS, which spilled into humans—likely from camels—in 2012; and SARS-CoV-2, the pandemic pathogen that’s been plaguing us since the end of 2019. Common-cold-causing coronaviruses, too, remain a fixture of daily living—likely relics of ancient animal-to-human spillovers that we kept transmitting amongst ourselves.

    Paramyxoviruses, meanwhile, have mostly been “simmering in the background,” says Raina Plowright, a disease ecologist at Cornell. Unlike flu viruses and coronaviruses, which have already clearly “proven themselves” as tier-one outbreak risks, paramyxoviruses haven’t yet been caught causing a bona fide pandemic. But they seem poised to do so, and they likely have managed the feat in the past. Like flu viruses and coronaviruses, paramyxoviruses can spread through the air, sometimes very rapidly. That’s certainly been the case with measles, a paramyxovirus that is “literally the most transmissible human virus on the planet,” says Paul Duprex, a virologist at the University of Pittsburgh. And, like flu viruses and coronaviruses, paramyxoviruses are found in a wide range of animals; more are being discovered wherever researchers look. Consider canine distemper virus, which has been found in, yes, canines, but also in raccoons, skunks, ferrets, otters, badgers, tigers, and seals. Paramyxoviruses, like flu viruses and coronaviruses, have also repeatedly shown their potential to hopscotch from those wild creatures into us. Since 1994, Hendra virus has caused multiple highly lethal outbreaks in horses, killing four humans along the way; the closely related Nipah virus has, since 1998, spread repeatedly among both pigs and people, carrying fatality rates that can soar upwards of 50 percent.

    The human versions of those past few outbreaks have petered out. But that may not always be the case—for Nipah, or for another paramyxovirus that’s yet to emerge. It’s entirely possible, Plowright told me, that the world may soon encounter a new paramyxovirus that’s both highly transmissible and ultra deadly—an “absolutely catastrophic” scenario, she said, that could dwarf the death toll of any epidemic in recent memory. (In the past four years, COVID-19, a disease with a fatality rate well below Nipah’s, has killed an estimated 7 million people.)

    All that said, though, paramyxoviruses are a third-place contender for several good reasons. Whereas flu viruses and coronaviruses are speedy shape-shifters—they frequently tweak their own genomes and exchange genetic material with others of their own kind—paramyxoviruses have historically been a bit more reluctant to change. “That takes them down a level,” says Danielle Anderson, a virologist at the Doherty Institute, in Melbourne. For one, these viruses’ sluggishness could make it much tougher for them to acquire transmission-boosting traits or adapt rapidly to spread among new hosts. Nipah virus, for instance, can spread among people via respiratory droplets at close contact. But even though it’s had many chances to do so, “it still hasn’t gotten very good at transmitting among humans,” Patricia Thibault, a biologist at the University of Saskatchewan who studied paramyxoviruses for years, told me.

    The genetic stability of paramyxoviruses can also make them straightforward to vaccinate against. Our flu and coronavirus shots need regular updates—as often as annually—to keep our immune system apace with viral evolution. But we’ve been using essentially the same measles vaccine for more than half a century, Duprex told me, and immunity to the virus seems to last for decades. Strong, durable vaccines are one of the main reasons that several countries have managed to eliminate measles—and why a paramyxovirus called rinderpest, once a major scourge of cattle, is one of the only infectious diseases we’ve ever managed to eradicate. In both cases, it helped that the paramyxovirus at play wasn’t great at infecting a ton of different animals: Measles is almost exclusive to us; rinderpest primarily troubled cows and their close kin. Most flu viruses and SARS-CoV-2, meanwhile, can spread widely across the tree of animal life; “I don’t know how you can eradicate that,” Anderson told me.

    The problem with all of these trends, though, is that they represent only what researchers know of the paramyxoviruses they’ve studied—which is, inevitably, a paltry subset of what exists, says Benhur Lee, a virologist at Mount Sinai’s Icahn School of Medicine. “The devil we don’t know can be just as frightening,” if not more, Lee told me. A pattern-defying paramyxovirus may already be readying itself to jump.

    Researchers are keyed into these looming threats. The World Health Organization highlights Nipah virus and its close cousins as some of its top-priority pathogens; in the U.S., paramyxoviruses recently made a National Institute of Allergy and Infectious Diseases list of pathogens essential to study for pandemic preparedness. Last year, the Bill & Melinda Gates Foundation announced a hefty initiative to fund paramyxovirus antiviral drugs. Several new paramyxovirus vaccines—many of them targeting Nipah viruses and their close relatives—may soon be ready to debut.

    At the same time, though, paramyxoviruses remain neglected—at least relative to the sheer perils they pose, experts told me. “Influenza has been sequenced to death,” Lee said. (That’s now pretty true for SARS-CoV-2 as well.) Paramyxoviruses, meanwhile, aren’t regularly surveilled for; development of their treatments and vaccines also commands less attention, especially outside of Nipah and its kin. And although the family has been plaguing us for countless generations, researchers still don’t know exactly how paramyxoviruses move into new species, or what mutations they would need to become more transmissible among us; they don’t know why some paramyxoviruses spark only minor respiratory infections, whereas others run amok through the body until the host is dead.

    Even the paramyxoviruses that feel somewhat familiar are still surprising us. In recent years, scientists have begun to realize that immunity to the paramyxovirus mumps, once thought to be pretty long-lasting and robust, wanes in the first few decades after vaccination; a version of the virus, once thought to be a problem only for humans and a few other primates, has also been detected in bats. For these and other reasons, rubulaviruses—the paramyxovirus subfamily that includes mumps—are among the potential pandemic agents that most concern Duprex. Emmie de Wit, the chief of the molecular-pathogenesis unit at Rocky Mountain Laboratories, told me that the world could also become more vulnerable to morbilliviruses, the subfamily that includes measles. If measles is ever eradicated, some regulators may push for an end to measles shots. But in the same way that the end of smallpox vaccination left the world vulnerable to mpox, the fall of measles immunity could leave an opening for a close cousin to rise.

    The next pandemic won’t necessarily be a paramyxovirus, or even a flu virus or a coronavirus. But it has an excellent chance of starting as so many other known pandemics have—with a spillover from animals, in parts of the world where we’ve invaded wild habitats. We may not be able to predict which pathogen or creature might be involved in our next big outbreak, but the common denominator will always be us.

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    Katherine J. Wu

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  • Struggling to Become a Twitch Partner? Even the CEO Faces Rejection!

    Struggling to Become a Twitch Partner? Even the CEO Faces Rejection!

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    Difficult to become a Twitch Partner, for everyone…even the big boss!

    The world of streaming on Twitch is more competitive than ever and even the CEO of the platform, Daniel Clancy, experienced it first hand. The CEO of Twitch, who streams on the platform in his spare time, revealed on Twitter/X that he had submitted a secret application to the Twitch Partner Program, but it was rejected. To be admitted to the Twitch Partner Program, streamers must meet several strict criteria, including an average of around 75 viewers per broadcast, excluding views from hosting, raids, first page or integrations. Clancy’s candidacy was rightly rejected because the attendance of his streams was too fluctuating.

    A Partner Program too difficult to reach?

    This rejection recalls the challenges many streamers face when aspiring to become Partners on Twitch. Streamers who are not CEO of a multinational, and often have more need of the income that could result from it. Even though we can regularly hear criticism on this subject, the Partner Program is still quite strict. And for good reason, it offers Streamer-exclusive benefits, such as monetization opportunities, channel customization, expanded VOD storage, and priority support. The requirement for a constant and high attendance makes accessing the Partner Program difficult, even for established streamers. This is, among other things, what pushes a very large number of them to stream every day of the year or almost.

    It’s not humans who decide?

    The rejection of the CEO’s candidacy sparked amused reactions from many Internet users, because it is funny to say the least. We also saw some encouraging reactions to push Dan Clancy to persevere, because one day, he will have his partnership! Above all, for some, it may have proven one thing. One thing Twitch – like most social platforms – wouldn’t easily admit: that many things, and in particular the Partner Program, are not managed by humans, but robots. Indeed, a robot does not differentiate between Dan Clancy or another streamer, but judges them all the same way. A human on the other hand… One wonders if a Twitch employee had had to evaluate Dan Clancy’s Partner Program application, would he have validated it? even if it did not completely meet the required criteria?

    Find our guide to choosing the best streaming hardware if you want to get started on Twitch or another platform.

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    Alice Zampa

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  • An Unusual Theory Suggests That Sex Helps the Body Tolerate a Fetus

    An Unusual Theory Suggests That Sex Helps the Body Tolerate a Fetus

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    In the early 1990s, while studying preeclampsia in Guadeloupe, Pierre-Yves Robillard hit upon a realization that seemed to shake the foundations of his field. Preeclampsia, a pregnancy complication that causes some 500,000 fetal deaths and 70,000 maternal deaths around the world each year, had for decades been regarded as a condition most common among new mothers, whose bodies were mounting an inappropriate attack on a first baby. But Robillard, now a neonatologist and epidemiologist at Centre Hospitalier Universitaire de La Réunion, on Réunion Island in the Indian Ocean, kept seeing the condition crop up during second, third, or fourth pregnancies—a pattern that a few other studies had documented, but had yet to fully explain. Then, Robillard noticed something else. “These women had changed the father,” he told me. The catalyst in these cases of preeclampsia, he eventually surmised, wasn’t the newness of pregnancy. It was the newness of paternal genetic material that, maybe, the mother hadn’t had enough exposure to before.

    Robillard’s idea was unconventional not only because it challenged the dogma of the time, but because it implied certain evolutionary consequences. Preeclampsia appears to be exclusive (or almost exclusive) to humans, and may have arisen as a by-product of the particularly aggressive ways in which our fetuses pillage their mother’s body for resources. So, Robillard and his colleagues posited, maybe the dangers it poses then pressured humans into developing a bizarre trait: being rather inefficient at conceiving offspring. Maybe, if humans aren’t terribly fertile, they need to have a lot of sex; maybe having a lot of sex repeatedly exposes a mother to her partner’s semen, inuring her to the molecular makeup of future offspring. If preeclampsia is a kind of immune overreaction, then perhaps unprotected sex is the world’s most unconventional allergy shot.

    That, at least, is what Robillard and his colleagues contend—a notion that’s “a bit controversial, and a bit awkward,” Inkeri Lokki, an immunologist and reproductive biologist at the University of Helsinki, told me. She remembers a senior researcher in the field once framing the upshot of the hypothesis as “pick your partner early, and practice.”

    Foreign genetic material aside, a mother’s body has every reason to be wary of a fetus. Pregnancy is an intergenerational struggle in which the fetus tries to pillage all the nutrients it can from the mother’s tissues, while the mother tries to keep some of her own resources in reserve.

    For most mammals, the two parties easily reach a lasting stalemate. Among humans, though, the fetus starts “with the upper hand,” Amy Boddy, an evolutionary biologist at UC Santa Barbara, told me. Whether it’s because of the extreme nutritional demands of our energy-guzzling brain, or just a constraint of how the primate lineage evolved, no other developing mammal invades quite as vigorously as the human embryo does: Through two waves of invasion, our placental cells burrow so deeply into the lining of the uterus that they breach its muscular layer, where they unfurl, melt, and rewire an entire set of blood vessels until they widen and relax. In the process, tissues liquify, and cells are forced apart, all to get an enormous amount of “blood delivered to the placenta,” Julienne Rutherford, a biological anthropologist at the University of Arizona College of Nursing, told me.

    The fetus thrives in these conditions—but it also asks so much of the mother’s body that it almost invites pushback. Preeclampsia, then, at least when it appears prior to 34 weeks of gestation, is arguably a manifestation of a human mother’s defenses wising up to the invasion, then kicking into overdrive. When researchers examine tissue samples in early-onset preeclampsia cases, they tend to find that the placenta has been prevented from invading the uterus thoroughly enough, Haley Ragsdale, a biological anthropologist at Northwestern University, told me. Now at risk of starving, the fetus tries to juice more from mom—in part by raising maternal blood pressure, preeclampsia’s hallmark symptom. (High blood pressure that arises in the last few weeks of pregnancy can signal late-onset preeclampsia, but researchers generally think the causes are distinct.)

    Why exactly the placenta’s invasion flags in early-onset cases remains contentious, Offer Erez, an ob-gyn at Soroka University Medical Center, in Israel, told me. One possibility, as Robillard and others argue, is that a mother’s immune system, unaccustomed to her partner’s particular blend of molecules, codes the fetus as foreign, and dispatches a fleet of defenses to waylay the threat. If that’s indeed the case, a logical workaround might involve familiarizing her body with those foreign substances—and nipping her overreaction in the bud.

    Semen could do the trick: It’s chock-full of paternal material, and introduced into the vaginal tract, where a legion of immune cells and molecules roam. It also contains signaling molecules that might be able to mollify the maternal immune system. Repeat exposures with no harm send a clear message: I am safe, says Gustaaf Dekker, who leads the department of obstetrics and gynecology at Northern Adelaide Local Health Network, in Australia, and who has collaborated for years with Robillard.

    In the past three decades, Dekker, Robillard, and their colleagues have amassed a large amount of evidence to support that idea. Across several populations, the risk of early-onset preeclampsia seems to be higher among couples conceiving for the first time; it’s also higher among people using donor sperm and eggs. The risk also seems lower among couples who have a lot of penetrative or oral sex before they get pregnant—at least, if they skip the condoms, some studies suggest. There’s even evidence that repeat exposures to seminal fluid can make female mice more tolerant of cells sampled from their mates.

    From an evolutionary perspective, the theory goes even further. If it is important to indoctrinate the maternal immune system with semen, “that is a strong selective pressure” for humans to adopt a suite of behaviors to facilitate that exposure, says Bernard Crespi, an evolutionary biologist at Simon Fraser University, in Canada, who’s collaborated with Robillard. Our bodies’ combative approach to placentation could help to explain our semi-monogamous nature, our comparably low fertility among mammals, and our comparatively large testes, which can provide a generous supply of sperm. It may even have influenced the unusual ways in which the female human body conceals its own fertility. Unlike other mammals, we don’t regularly enter an obvious period of heat, or visibly signal when we ovulate—both traits that encourage more frequent sex in pursuit of reproduction. If repeat couplings are just kind of our thing, maybe it’s because they make our pregnancies that much safer.

    The paternal-immunity hypothesis is not the only possible explanation for early-onset preeclampsia, and for some researchers, it is far from the strongest one. Fathers could be playing a different role in the condition. Some evidence suggests that certain males pass down DNA that predisposes their offspring to implant a bit differently in the womb, Laura Schulz, a women’s-health researcher at the University of Missouri School of Medicine, pointed out to me. And Carlos Galaviz Hernández, a geneticist at CIIDIR Unidad Durango, in Mexico, told me that immune compatibility may matter, too: The mother might be able to better tolerate some partners, analogous to the way that organ transplants are more successful if certain molecular signatures match. In some cases, the mother’s DNA may be the dominant force. Certain women, for instance, seem genetically predisposed to developing the condition, regardless of whom they partner with.

    Jimmy Espinoza, a maternal-fetal-medicine specialist at UTHealth Houston’s McGovern Medical School, also pointed out to me that the idea Robillard has championed has its own scientific issues. In recent years, especially, other teams of researchers have found evidence that seems to directly contradict it—in some cases, finding that some people may reduce their chances of preeclampsia if they switch to a different partner for a subsequent child. (Dekker and Robillard argue that several of these studies had issues, including possible misdiagnoses and not distinguishing enough between early- and late-onset preeclampsia.)

    All of these ideas may have some truth to them—in part because preeclampsia, like cancer, is a catchall term for different disease pathways that manifest similarly at their tail end, Andrea Edlow, a maternal-fetal-medicine specialist at Massachusetts General Hospital, told me. And despite evidence to the contrary, “I still support the hypothesis,” Dekker told me. In his opinion, “nobody has come up with a better one.”

    Even if the semen hypothesis turns out to be correct, it’s hard to know what to do with that information. Breakthroughs are desperately needed: Although preeclampsia has been documented for millennia, diagnostics, treatments, and preventives are scant. Maybe better understanding paternal exposures will someday lead to preconception vaccines, or targeted immunotherapies for people deemed high risk. Today, though, the idea’s most actionable takeaways are very limited. In Robillard’s ideal world, clinicians would recommend at least six months of sexually active cohabitation, or at least 100 sexual encounters, before conception; pregnant people would also routinely disclose their sexual history with their partner to their doctor, and changes in partners would be noted in medical charts. Unsurprisingly, “it’s been an uphill battle” to sell some of those ideas to colleagues, Dekker told me.

    Edlow, for one, generally supports the idea of paternal tolerance. But “it’s not something I would talk to patients about,” she told me. Sarah Kilpatrick, the chair of the department of obstetrics and gynecology at Cedars-Sinai, in Los Angeles, feels similarly. There’s just not quite enough evidence to build a recommendation, she told me—and designing a large clinical trial to rigorously test these ideas is difficult, especially for a condition with such serious risks.

    Plus, a pre-pregnancy injunction to have more sex to lower the risk of preeclampsia can only really apply to a very specific audience. It assumes heterosexuality; it implies monogamy. Even the amount of sex that Robillard advocates for could pose a challenge for some couples who meet those criteria. And heterosexual, monogamous couples hardly represent the full universe of people who are getting pregnant—among them people who are pursuing single parenthood, who get pregnant through intrauterine insemination or in vitro fertilization, who are seeking donor sperm or embryos, and who get pregnant quickly or perhaps unintentionally. And although the chances of preeclampsia may be slightly elevated in some of those cohorts, in the broadest terms, “why person X gets it, and why person Y doesn’t get it, we just don’t know,” Kilpatrick told me. Plus, a clinical strategy that pushes for, or even seems to justify, long-term sexual monogamy puts medical professionals in the position of actively prescribing a very specific and limited vision of human sexuality, Rutherford, the biological anthropologist, told me.

    Frankly, Edlow told me, “I don’t want to take this condition that affects pregnancy and make it all about men’s sperm.” There may yet be other ways to trigger tolerance, or keep the maternal immune system in check. Preeclampsia, for whatever reason, may be an evolutionary snarl our lineage got tangled up in. But to address it, or even solve it, people may not need to bend to evolution’s whims.

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    Katherine J. Wu

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  • The Robots Are Coming — But Some Jobs Are Better Left To Us Humans. | Entrepreneur

    The Robots Are Coming — But Some Jobs Are Better Left To Us Humans. | Entrepreneur

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    Opinions expressed by Entrepreneur contributors are their own.

    It doesn’t take much reading to see that artificial intelligence (AI) is rapidly upending our ideas of which activities need to be performed by living, breathing humans. From data analytics to content creation, big businesses and fledgling entrepreneurs alike are experimenting with a wide variety of ways to use AI to cut costs and bolster their bottom line.

    But even with the seeming rush to use artificial intelligence, the value of human-to-human contact cannot be overlooked — especially in those activities that involve direct interaction with the end consumer.

    Turning over your business to robots may seem like a more efficient option, but neglecting human-to-human interactions could ultimately hurt your business in the long run.

    Related: The Human Touch: What It Takes To Maintain Meaningful Client Relationships In A World Driven By Artificial Intelligence

    Many people prefer human interaction over AI

    Notably, even with more people being willing to use artificial intelligence, the vast majority aren’t ready to give up on human contact. For example, a study from Faye Travel Insurance found that while 18% of travelers prefer to use a virtual travel assistant, 23% prefer working exclusively with a human travel agent — and 51% prefer to use both options.

    As this study shows, more often than not, artificial intelligence is being used as a supplemental form of assistance (if it is being used at all) because people still want some form of human help and connection.

    Another example comes from an article published by the University of British Columbia School of Social Work, which notes that while AI has helped offer more resources in the field of social work, many people in need of mental and emotional support are putting a premium on getting assistance from living, breathing people.

    Notably, the article cites the experience of a computer programmer who had access to an online support bot to help address trauma related to a motor vehicle accident. The patient didn’t use the support bot or his online support group because, as he explained, “I prefer talking to real people.”

    Neither of these examples is meant to downplay the fact that many people do use AI for these and other activities — and sometimes prefer it to getting human help. But in an increasingly digital society, the vast majority of people still want some type of human-to-human connection in some aspect of their lives.

    Whether it comes down to trust, personal preference or the need for emotional attachment, there is no denying that people want real, meaningful interaction with other human beings. Even in a recent survey that found that 73% of consumers believe AI can positively impact the customer experience, 77% still said “an element of human touch” was needed to create positive experiences.

    Related: The Human Element: Your Most Important Business Resource

    AI cannot replace real, human innovation

    Writing for The New York Times, columnist David Brooks notes that while AI is poised to provide tools for outsourcing mental work, it also lacks several traits that are inherently human — things that AI can’t truly replicate. As Brooks explains, AI can’t produce a distinct personal voice, true creativity, unusual worldviews, empathy or situational awareness.

    These uniquely human attributes are especially vital when dealing with individuals — whether they be an employee or a customer. Artificial intelligence may be good at identifying patterns and trends, but it is not equipped to form a meaningful, authentic emotional relationship with an individual.

    In his column, Brooks was advising college students on the skills they should develop to set themselves apart as they start their careers. But these same attributes are certainly valuable to entrepreneurs and their businesses as well. Unusual worldviews and creativity are often defining attributes of entrepreneurs that help them develop new ideas to revolutionize industries.

    Of course, such attributes become even more valuable when working with other human partners to generate ideas and solve problems. For example, brainstorming is often cited as a valuable business activity because it forces decision-makers to consider different points of view and avoid groupthink. It encourages critical thinking as people share and evaluate their ideas and perspectives.

    Most importantly, it builds a sense of cohesion as multiple people come together to collaborate and work on a solution. AI can certainly help in this process, such as by helping predict the outcomes of different actions or decisions. But it is unlikely to bring that same energy to the room that you get when going through the work with other people. And its own ideas and output, while they may be useful, aren’t going to be as creative or unique as what your own team might come up with.

    Related: Is AI A Risk To Creativity? The Answer Is Not So Simple

    Don’t forget to be human

    Can AI tools help your business become more efficient? Absolutely. But this doesn’t necessarily mean you should go all-in on trying to automate every last activity. People crave real, human communication and contact. There are many things that machines can do, but it’s important to remember they can’t replace genuine human contact.

    In a day when so many are rushing to use artificial intelligence, remembering to be human could be what helps set your business apart. As you learn to use AI to supplement your efforts while still maintaining a strong focus on the human element that you and your team members have to offer, you can unlock new opportunities and ideas while providing the connection that we all so desperately need.

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    Lucas Miller

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  • Jimmy Carter Wins Boxing Match Against Jake Paul

    Jimmy Carter Wins Boxing Match Against Jake Paul

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    ATLANTA—The heavily anticipated fight between the former U.S. president and the YouTube personality ended in a TKO Thursday night as Jimmy Carter won his debut boxing match against Jake Paul. The cruiserweight match, first announced in early April, pitted the 6-foot-1, 191-pound Paul against the 5-foot-10, 190-pound Carter in the the final fight on the evening’s card. The first two rounds featured even sparring, with the 26-year-old social media star and the 98-year-old known for his humanitarian work trading jabs and fighting conservatively as Carter made up for his shorter reach with quicker hand speed and better mobility. As the third round went on and Paul visibly tired, Carter gained the upper hand, viciously landing a flurry of blows on the influencer before the bell. The former Georgia governor’s reported nine months of 10-hour daily training sessions paid off when he landed a devastating right hook 12 seconds into the fourth round and knocked Paul to the ground, winning the match and along with it a $600,000 purse. Bloodied and grinning to show off a lost tooth as the referee raised his arm in victory, Carter repeatedly bellowed “Rosalynn” as the former first lady fought through the swarming crowd, climbed into the ring, and embrace her victorious husband.

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  • Linus Is Stepping Down As CEO Of Linus Media Group

    Linus Is Stepping Down As CEO Of Linus Media Group

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    Screenshot: YouTube

    Canadian YouTuber Linus Sebastian, best known to most as the guy behind the insanely popular Linus Tech Tips channel, has announced that he’s stepping down as CEO of the companies he helped create and has been running for the past ten years.

    In a 10-minute video called “It’s time”, Sebastian announces that as of July 1 he’ll no longer be heading up Linus Media Group, the company that not only runs the Linus Tech Tips show but also companies like Creator Warehouse and Floatplane Media as well.

    I’m Stepping Down..

    “I wasn’t built for this, and I’m tired”, he says. “Like ‘really can’t do this anymore’ tired. And if I try to drag myself through another 10 years of business administration I know I’m gonna destroy myself, and probably end up killing the company and the community that I love so much in the process”.

    Of course he isn’t leaving the show or YouTube altogether. We’d have said that up top if he were. Instead he’ll be moving into a new job called “Chief Vision Officer”—which he admits is “a stupid, BS-sounding, made-up role”—which will allow him to not just keep making videos, but maybe even appear in more of them, since he’ll have been freed up to do so without having to focus on all the business stuff that comes with being CEO of a company that at time of publishing has around 100 employees.

    Interestingly, Sebastian says that at the same time he was making this decision, Linus Media received an offer of $100 million to “sell out”, which was in the form of 60% cash straight-up, and 40% equity in the (undisclosed) purchasing company. Linus decided to turn it down, though, citing a combination of factors like the fact they liked working with the company as it was and that, to be real, they were already super rich already.

    Terren Tong, previously with Corsair, will replace Sebastian as CEO.

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    Luke Plunkett

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  • Your Next Mosquito Repellent Might Already Be in Your Shower

    Your Next Mosquito Repellent Might Already Be in Your Shower

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    For as long as I can remember, I have been that friend—the one who, from May to November, gets invited to every outdoor soiree. It’s not because I make the best desserts, even though I do. It’s because, with me around, the shoes can come off and the DEET can stay sheathed: No one else need fear for their blood when the mosquitoes are all busy biting me.

    Explanations abound for why people like me just can’t stop getting nipped—blood type, diet, the particular funk of the acids that emanate from our skin. Mosquitoes are nothing if not expert sniffers, evolving over millennia to detect the body’s many emissions, including the carbon dioxide we exhale and the heat we radiate.

    But to focus only on a mosquito’s hankering for flesh is to leave a whole chapter of the pests’ scent-seeking saga “largely overlooked,” Clément Vinauger, a chemical ecologist at Virginia Tech, told me. Mosquitoes are omnivores, tuned to sniff out blood and plants. And nowadays, most humans, especially those in the Western world, tend to smell a bit like both, thanks to all the floral, citrusy lotions and potions that so many of us slather atop our musky flesh.

    That medley of scents, Vinauger and his colleagues have discovered, may be an underappreciated part of what makes people like me smell so darn good to pests. The findings are from a small study with just five volunteers, four brands of soap, and one mosquito species, and still need to be confirmed outside the lab. But they’re a reminder that, as good or as bad as some of us might inherently smell to a mosquito, the insects experience us as dietarily diverse smorgasbords—not just as our animal selves.

    Researchers have also long known that “everything we use on our skin will affect mosquitoes’ behavior or attraction toward us,” says Ali Afify, a mosquito researcher at Drexel University. That includes extracts from plants—among them, chemicals such as citronella and limonene, which have both been found to repel the bloodsucking insects in at least some contexts. Something about encountering floral and faunal cues together seems to bamboozle mosquitoes, as if they’re “seeing an organism that doesn’t exist,” says Baldwyn Torto, a chemical ecologist and mosquito expert at the International Centre of Insect Physiology and Ecology. After all, female mosquitoes, the only ones that bite, spend their lives toggling between seeking nectar and hunting for blood, but never both at the same time. That’s part of why Vinauger initially figured that soap might deter mosquitoes from flying in for a sip.

    The story ended up being a bit more complicated. The researchers, led by Morgen VanderGiessen and Anaïs Tallon, collected chemicals from their volunteers’ arms—one scrubbed with soap, the other left aromatically bare—and offered them to the mosquitoes. One body wash, a coconut-and-vanilla-scented number made by Native, seemed to make a subset of people less appetizing, probably in part, Vinauger told me, because mosquitoes and other insects are not into coconut. (Duly noted.) But two other cleansers, made by Dove and Simple Truth, bumped up the attractiveness of several of their volunteers—even though all of the soaps in the study contained plenty of limonene. (None of the manufacturers of the body washes used in the study responded to a request for comment.)

    No single product was a universal attractant or repellent, which probably says more about us than it does about body wash. A bevy of lifestyle choices and environmental influences can tweak an individual’s unique odor profile; even identical twins, Torto told me, won’t smell the same to a mosquito on the prowl. Soaped up or no, some people will remain stubbornly magnetic to mosquitoes; others will continue to disgust them. This makes it “hard to say, ‘Hey, this soap will make you really attractive’ or ‘That soap will keep mosquitoes completely away from you,’” says Seyed Mahmood Nikbakht Zadeh, a chemical ecologist and medical entomologist at CSU San Bernardino, who wasn’t involved in the study. Plus, soap is hardly the only scented product that people use: Whatever enticing ingredients your body wash might contain, Tallon told me, could easily be counteracted by the contents of your lotion or deodorant.

    The point of the study isn’t to demonize or extol any particular products—especially considering how few soaps were tested and how many factors dictate each individual’s odor profile. The five volunteers in the study can’t possibly capture the entire range of human-soap interactions, though the researchers hope to expand their findings with a lot of follow-up. “I wouldn’t want the public to be alarmed about what type of soap they’re using,” Torto told me.

    But just knowing that personal-care products can alter a person’s appeal could kick-start more research. Scientists could design better baits to lure skeeters away from us, or develop a new generation of repellents using gentle, plant-based ingredients that are already found in our soaps. “DEET is really efficient, but it’s a chemical that melts plastic,” Vinauger told me. “Could we do better?”

    The researchers behind the study are already trying. After analyzing the specific chemicals in each of the soaps they tested, they blended some of the most alluring and aversive substances into two new concoctions—a flowery, fruity attractant and a nuttier repellent—and offered them to the insects. The repellent was “as strong as applying DEET on your skin,” Vinauger told me, “but it’s all coming from those soap chemicals.”

    What’s not yet clear, though, is how long those powers of repulsion last. Most people don’t manage more than a daily scrub; meanwhile, “the odors coming out of your pores are continuously coming out, so in the long run, those might win out,” says Maria Elena De Obaldia, a neurogeneticist who previously studied mosquito attraction at Rockefeller University. And it’s a lot less practical to ask someone to shower every few hours than to simply reapply bug spray.

    I’m certainly not ready to blame my mosquito magnetism on my body wash (which, for what it’s worth, contains a lot of “coconut-based cleanser”) or anything else in my hygiene repertoire. Part of the problem is undoubtedly just me—the tastiest of human meat sticks. But the next time I shop for anything scented, I’ll at least know that whatever wafts out of that product won’t just be for me. Some pest somewhere is always catching a stray whiff.

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    Katherine J. Wu

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