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Tag: Heart Disease

  • Not eating enough of these six healthy foods is associated with higher cardiovascular disease and deaths globally

    Not eating enough of these six healthy foods is associated with higher cardiovascular disease and deaths globally

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    Embargoed by the European Heart Journal until Thursday, July 6 at 7:05 (EDT)

    Newswise — HAMILTON, ON (July 6, 2023) – A study led by McMaster University and Hamilton Health Sciences researchers at the Population Research Health Institute (PHRI) has found that not eating enough of six key foods in combination is associated with a higher risk of cardiovascular disease (CVD) in adults.

    Consuming fruits, vegetables, legumes, nuts, fish and whole-fat dairy products is key to lowering the risk of CVD, including heart attacks and strokes. The study also found that a healthy diet can be achieved in various ways, such as including moderate amounts of whole grains or unprocessed meats.

    Previous and similar research has focused on Western countries and diets that combined harmful, ultra-processed foods with nutrient-dense foods. This research was global in scope and focused on foods commonly considered to be healthy.

    The World Health Organization estimates nearly 18 million people died from CVD in 2019, representing 32 per cent of all global deaths. Of these deaths, 85 per cent were due to heart attacks and strokes. PHRI researchers and their global collaborators analyzed data from 245,000 people in 80 countries from multiple studies. The results were published in the European Heart Journal on July 6.

    Researchers derived a diet score from PHRI’s ongoing, large-scale global Prospective Urban and Rural Epidemiological (PURE) study, then replicated that in five independent studies to measure health outcomes in different world regions and in people with and without prior CVD.

    “Previous diet scores – including the EAT-Lancet Planetary Diet and the Mediterranean Diet tested the relationship of diet to CVD and death mainly in Western countries. The PURE Healthy Diet Score included a good representation of high, middle, and low-income countries,” said Salim Yusuf, senior author and principal investigator of PURE.

    As well as being truly global, the PURE Healthy Diet Score focused on exclusively protective, or natural, foods.

    “We were unique in that focus. The other diet scores combined foods considered to be harmful – such as processed and ultra-processed foods – with foods and nutrients believed to be protective of one’s health,” said first author Andrew Mente, PHRI scientist and assistant professor at McMaster’s Department of Health Research Methods, Evidence, and Impact.

    “There is a recent increased focus on higher consumption of protective foods for disease prevention. Outside of larger amounts of fruits, vegetables, nuts and legumes, the researchers showed that moderation is key in the consumption of natural foods,” he said.

    “Moderate amounts of fish and whole-fat dairy are associated with a lower risk of CVD and mortality. The same health outcomes can be achieved with moderate consumption of grains and meats – as long as they are unrefined whole grains and unprocessed meats.”

    The PURE Healthy Diet Score recommends an average daily intake of: Fruits at two to three servings; vegetables at two to three servings; nuts at one serving; and dairy at two servings. The score also includes three to four weekly servings of legumes and two to three weekly servings of fish. Possible substitutes included whole grains at one serving daily, and unprocessed red meat or poultry at one serving daily.

    There was no specific funding for this analysis, although each study that contributed data was funded separately and conducted over a 25-year period.

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    A photo of Andrew Mente can be found at: https://macdrive.mcmaster.ca/d/d7cfaeb9c6ac4cfb80f0/

     

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    McMaster University

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  • Heart condition POTS may be linked to COVID

    Heart condition POTS may be linked to COVID

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    Heart condition POTS may be linked to COVID – CBS News


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    COVID-19 infections may be linked to an increase in the heart condition known as POTS, in which a person’s heart rate can spike suddenly. Nikki Battiste reports.

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  • Serious monkey business: chimpanzee heart check via digital camera

    Serious monkey business: chimpanzee heart check via digital camera

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    Newswise — A world-first experiment to measure chimpanzee heart rates via a digital camera could help curb cardiovascular disease in great apes in captivity and provide valuable insights into how their brain develops from an early age.

    Using a contact-free technique to extract cardiac signals from chimpanzees by filming subtle movements in their face or thorax, and monitoring their emotional response to different stimuli, a team of researchers led by the University of South Australia (UniSA) has made some startling discoveries.

    Chimpanzees – our closest living relatives – show similar responses to human babies when they experience fear, excitement, or joy, causing their heart rate to increase or decrease.

    Their response to videos of nature scenes is also the same as humans, relaxing them and lowering their heart rate significantly, despite not being familiar with the environment.

    By monitoring their heart rates from a distance, researchers are confident they can pinpoint early signs of cardiac disease in chimpanzees – one of the main causes of mortality in captive great apes – and flag these endangered animals for treatment.

    Seven chimpanzees were filmed in captivity from a short distance at the Wolfgang Koehler Primate Research Centre in Leipzig, Germany, for the study. UniSA engineers were sent the footage and used artificial intelligence to determine the heart rates.

    Remote sensing engineer UniSA Professor Javaan Chahl says it is the first time that chimpanzee heart rates have been recorded by a digital camera, extracting cardiac signals from their facial hues using image-processing algorithms.

    Previous studies have either relied on sensors attached to the chimpanzee’s body, requiring primates in captivity to be trained to tolerate them, or ensuring the animal is anaesthetised before undertaking basic health checks.

    The researchers not only recorded chimpanzee heart rates using the new technology, but also compared how the apes’ heart rates changed when shown videos of aggressive behaviour between chimpanzees from different groups, scenes of chimpanzees eating, and nature videos.

    Lead author, UniSA PhD student Danyi Wang, says the apes’ heart rate increased when viewing video footage of chimps fighting and feeding, and slowed when looking at nature scenes.

    “Heart rate changes can be linked to emotional responses, mental effort, attention and focus,” Danyi says. “Babies show emotional responses early in development, which can be observed by physiological changes that help them adapt and integrate into their environment. We observed the same in the chimpanzees we monitored.

    “Their responses to viewing nature scenes could be an innate physiological response to the natural world. We know that when humans spend time in nature, or view nature-related stimuli, it has a calming effect. It appears nature has the same effect on chimpanzees, and this could be deeply rooted in our evolutionary history.”

    Because primates have similar DNA to humans, monitoring their physiological changes may provide vital information about the development of their thinking, attention, language, learning, memory and perception.

    Prof Chahl says, as with human infants, heart rate measures could be used to test recognition memory and therefore help reveal mental processes in different contexts.

    “This would not only complement existing efforts to understand the evolution of cognition, but it would also enable us to test populations that otherwise do not engage in cognitive tasks, such as very young or untrained primates.”

    Cardiovascular disease is very common in captive great apes, typically due to age-related changes, thickening of the heart muscles and reduced elasticity. By monitoring their heart, researchers believe they will be able to detect abnormal heart rhythms and potential signs of cardiac disease earlier.

    “Our contact-free technique opens up new routes to study primates’ emotional and cognitive states and may also greatly enhance the health management of a wide range of animal species,” Prof Chahl says.

    The study is published in Behaviour Research Methods, one of the world’s leading journals in experimental psychology.

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  • Martin/Hopkins Method to Calculate LDL Or ‘Bad’ Cholesterol Outperforms Other Equations, Study Shows

    Martin/Hopkins Method to Calculate LDL Or ‘Bad’ Cholesterol Outperforms Other Equations, Study Shows

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    Newswise — In a new large, comprehensive analysis that looked at data from more than 5 million patients, the Martin/Hopkins method developed by Johns Hopkins researchers to calculate low-density lipoprotein (LDL) cholesterol — so-called bad cholesterol — produces higher accuracy rates than the nearly two dozen other available equations.

    The findings, published June 19 in Global Heart, reveal that overall, the Martin/Hopkins algorithm correctly classified 89.6% of patients’ LDL cholesterol values, followed by the Sampson method (which was proposed by the National Institutes of Health), which correctly classified 86.3%. The previous gold standard of testing LDL cholesterol levels, the Friedewald method, correctly classified 83.2% of patients. An even larger advantage of the Martin/Hopkins algorithm was seen over other methods for patients with characteristics such low cholesterol and high triglyceride levels.

    For the study, researchers looked at data from October 2015 to June 2019, using the Very Large Database of Lipids — a cohort made up of 5,051,467 adult and pediatric patients. The average age was 56, and 53.3% were women. Analyzing 23 identified LDL cholesterol equations, the researchers found that following the Martin/Hopkins equation, those with the most accurate findings were Sampson, Chen (84.4%), Puavilai (84.1%), Delong (83.3%) and Friedewald. The other 17 equations were less accurate than Friedewald, with accuracy as low as 35.1%.

    Assessing LDL cholesterol is important for understanding the risk of stroke and heart disease, which is the #1 cause of death globally. High levels of LDL cholesterol are associated with buildup of plaque in the arteries that can narrow the blood vessels and restrict blood flow to the heart and the brain, which can lead to heart attack and stroke. By monitoring LDL cholesterol levels, clinicians can identify patients at higher risk and take measures to manage and reduce risk, such as recommending lifestyle changes or prescribing medications like statins and an increasing set of nonstatin medications.

    “The biggest concern is that underestimating LDL cholesterol could lead to withholding treatments that would be beneficial for patients,” says Seth Martin, M.D., M.H.S., senior study author a professor of medicine at the Johns Hopkins University School of Medicine and director of the advanced lipid disorders program at the Ciccarone Center for the Prevention of Cardiovascular Disease.

    Martin, along with his colleagues, created the Martin/Hopkins method in 2013. It has since been recommended by the American College of Cardiology and the American Heart Association, and it is used by several diagnostic laboratories in the United States and around the world. Before Martin/Hopkins was developed, the Friedewald equation was the most commonly used method to gauge LDL cholesterol. However, Martin says that method and others that followed underestimate LDL cholesterol and cardiovascular disease danger for people for whom accuracy matters most: those at high risk.

    “Underestimating LDL cholesterol falsely reassures patients that their LDL cholesterol level is fine when in reality it isn’t,” says Martin. “It’s higher than the lab is reporting and warrants clinical action.”

    The study also revealed the Martin/Hopkins algorithm to be the most accurate across multiple patient subgroups based on age, sex, triglyceride (fat in the bloodstream) levels and fasting status, as well as patients with atherosclerotic cardiovascular disease, diabetes, hypertension, inflammation, thyroid dysfunction and kidney disease.

    “Most proposed alternatives to the Friedewald equation worsen LDL cholesterol accuracy, and their use could introduce unintended disparities in clinical care,” says Martin. “We hope labs that are still using the Friedewald method take a look at our findings and see that it’s time to progress to an LDL cholesterol calculation that better serves patients in guiding lipid treatment to prevent heart disease and strokes.”

    Johns Hopkins Medicine has made the Martin/Hopkins method publicly available, and any lab can use it for free. It can be accessed at LDLcalculator.com.

    Other researchers on the study include Christeen Samuel, Erin Michos, Roger Blumenthal and Steven Jones of the Ciccarone Center for the Prevention of Cardiovascular Disease at the Johns Hopkins University School of Medicine, Jihwan Park with the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health and Aparna Sajja with the MedStar Georgetown University Hospital-Washington Hospital Center.

    Martin and Jones were listed as co-inventors on a patent application that The Johns Hopkins University filed for the Martin/Hopkins method of LDL cholesterol equation. However, the patent application was later abandoned to enable use without intellectual property restrictions.

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  • Researchers Find Major Link Between Cardiovascular Health and Disorders Such as Carpal Tunnel Syndrome, Rotator Cuff Tendinitis

    Researchers Find Major Link Between Cardiovascular Health and Disorders Such as Carpal Tunnel Syndrome, Rotator Cuff Tendinitis

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    Newswise — People with higher risks of cardiovascular disease are significantly more likely to develop carpal tunnel syndrome, tennis elbow, golfer’s elbow, and rotator cuff tendinitis, according to a new study involving researchers at the University of Utah and the Rocky Mountain Center for Occupational and Environmental Health.

    The findings of the study, published June 2 in the Journal of Occupational and Environmental Medicine, have implications for the prevention and treatment of these common musculoskeletal disorders, which affect tens of millions of Americans each year and result in annual costs of more than $6 billion. 

    The lead author of the study is Kurt Hegmann, M.D., a University of Utah professor and the director of the Rocky Mountain Center for Occupational and Environmental Health, a partnership between the University of Utah and Weber State University. He said the strength of the associations the researchers discovered between cardiovascular disease risk factors and musculoskeletal disorders is staggering.

    “It’s rare that you see 17-fold risks of diseases,” Hegmann said. “These results tell us that prioritizing cardiovascular health is a key to preventing these musculoskeletal disorders, which can have a debilitating impact on people’s quality of life. This is something we and other researchers and medical professionals need to be paying a lot of attention to.”

    The authors based their research on data from a nine-year prospective cohort of 1,224 workers across various employment sectors in three states. Baseline data were collected at the beginning of the study, including from interviews, physical exams, anthropometric measurements, and nerve conduction studies, with follow-ups conducted monthly to track the development of symptoms of musculoskeletal disorders. The authors compared the development of musculoskeletal disorders to cardiovascular disease risk through a method based on the Framingham Heart Study model, a widely used tool to assess a person’s 10-year risk for cardiovascular disease. They adjusted their analyses for a number of factors that could skew the results, such as body mass index and the physical strain of participants’ jobs. 

    The findings suggest that poor cardiovascular health contributes to the development of musculoskeletal disorders. Participants at 15% or higher risk of cardiovascular disease were:

    • at four times greater risk of developing one or more musculoskeletal disorders than those at low risk of cardiovascular disease
    • at 17 times greater risk of developing four or more musculoskeletal disorders than those at low risk of cardiovascular disease

    “The importance of heart health is obviously no secret,” said Matthew Thiese, PhD, a co-author from the Rocky Mountain Center for Occupational and Environmental Health. “We know that people need to engage in healthy behaviors so they don’t develop diseases that can shorten their lives. But this study shows that bad outcomes related to musculoskeletal disorders may also be waiting for people who aren’t taking care of their cardiovascular health.” 

    The musculoskeletal disorders the researchers examined are common among Americans and can impair a person’s quality of life. Previous research estimates that up to 5% of the population suffers from carpal tunnel syndrome, for instance, with much higher prevalence among workers whose jobs require forceful movements, while up to 41% of people experience tennis elbow, or lateral epicondylitis. Up to one-third of people develop rotator cuff tears.

    According to the authors, the study prompts questions regarding whether these kinds of conditions are a potential “early warning” signal for cardiovascular disease. Musculoskeletal disorders may occur in a person with poor heart health years or decades before symptoms of cardiovascular disease emerge.

    The findings align with a growing body of evidence that systemic risk factors contribute to developing musculoskeletal disorders. Limitations of the research include that the study was not a randomized control trial. Randomized studies are the gold standard in proving causality, though these types of exposures cannot be randomized.

    The other co-authors associated with the University of Utah included Eric Wood, MD, and Richard Kendall, MD. They conducted the study in collaboration with researchers from the University of Wisconsin-Milwaukee, Infinity Healthcare in Wisconsin, and the Clement J. Zablocki Veterans Affairs Medical Center in Wisconsin.

    About University of Utah Health

    University of Utah Health  provides leading-edge and compassionate care for a referral area that encompasses Idaho, Wyoming, Montana, and much of Nevada. A hub for health sciences research and education in the region, U of U Health has a $458 million research enterprise and trains the majority of Utah’s physicians, and more than 1,670 scientists and 1,460 health care providers at its Colleges of Health, Nursing, and Pharmacy and Schools of Dentistry and Medicine. With more than 20,000 employees, the system includes 12 community clinics and five hospitals. U of U Health is recognized nationally as a transformative health care system and provider of world-class care.

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    University of Utah Health

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  • Man repeatedly shocked with Taser by LAPD died from enlarged heart and cocaine use, coroner says

    Man repeatedly shocked with Taser by LAPD died from enlarged heart and cocaine use, coroner says

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    LOS ANGELES — A teacher who was repeatedly shocked with a Taser by Los Angeles police died from an enlarged heart and cocaine use, according to an autopsy report released Friday.

    The Jan. 3 death of Keenan Darnell Anderson, 31, prompted an outcry over the Los Angeles Police Department’s use of force. It was one of three fatal LAPD confrontations, including two shootings, that took place only days into the new year.

    The specific manner of Anderson’s death was undetermined but the cause was listed as “effects of cardiomyopathy and cocaine use” and his death was “determined hours after restraint and conducted energy device use,” the coroner’s report said.

    The family’s attorney, Carl Douglas, did not immediately respond to an email from The Associated Press Friday evening seeking comment on the report.

    Mayor Karen Bass said her thoughts were with Anderson’s friends and family “as I know the release of this report will cause them and many Angelenos great pain as they still mourn this loss.”

    “The coroner raises questions that still must be answered and I await the result of the investigation already underway,” Bass said in a statement.

    Anderson was a high school English teacher in Washington, D.C., and a cousin of Black Lives Matter co-founder Patrisse Cullors.

    He was visiting family members in Los Angeles when he was stopped on suspicion of causing a hit-and-run traffic accident in the Venice area, police said.

    An officer found Anderson “running in the middle of the street and exhibiting erratic behavior,” according to a police account.

    Anderson initially complied with officers as they investigated whether he was under the influence of drugs or alcohol, but then he bolted, Police Chief Michel Moore said.

    Police chased Anderson and he was shocked with a Taser at least six times during a struggle when he resisted arrest, police said.

    “They’re trying to George Floyd me,” Anderson said as an officer threatened to use a stun gun, which was repeatedly deployed seconds later as Anderson was face down on the pavement and begged for help, saying, “I’m not resisting.”

    Anderson screamed for help after he was pinned to the street by officers and repeatedly shocked, according to police body camera footage released by the LAPD. Footage also showed an officer pressing his forearm on Anderson’s chest and an elbow in his neck.

    “They’re trying to kill me,” Anderson yelled.

    After being subdued, Anderson went into cardiac arrest and died at a hospital about four hours later.

    His relatives have filed a $50 million claim with the city, which is a legal requirement before filing a lawsuit. The claim alleges officers unreasonably used deadly force, failed to follow training and filed false police reports.

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  • Nurse denied hospital requests for 8-year-old migrant girl who died in Border Patrol custody

    Nurse denied hospital requests for 8-year-old migrant girl who died in Border Patrol custody

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    Nurse denied hospital requests for 8-year-old migrant girl who died in Border Patrol custody – CBS News


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    A nurse who treated an 8-year-old migrant girl who fell ill and then died on May 17 at a Border Patrol facility in Harlingen, Texas, denied multiple requests from the girl’s family that she be taken to a hospital, federal officials confirmed Thursday. Anadith Tanay Reyes Alvarez suffered from sickle cell anemia and heart disease. Omar Villafranca has more.

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  • Despite flags, Border Patrol staff didn’t review fragile 8-year-old girl’s file before she died

    Despite flags, Border Patrol staff didn’t review fragile 8-year-old girl’s file before she died

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    HARLINGEN, Texas — Border Patrol medical staff declined to review the file of an 8-year-old girl with a chronic heart condition and rare blood disorder before she appeared to have a seizure and died on her ninth day in custody, an internal investigation found.

    U.S. Customs and Border Protection has said the child’s parents shared the medical history with authorities on May 10, a day after the family was taken into custody.

    But a nurse practitioner declined to review documents about the girl the day she died, CBP’s Office of Professional Responsibility said in its initial statement Thursday on the May 17 death. The nurse practitioner reported denying three or four requests from the girl’s mother for an ambulance.

    Anadith Tanay Reyes Alvarez, whose parents are Honduran, was born in Panama with congenital heart disease. She received surgery three years ago that her mother, Mabel Alvarez Benedicks, characterized as successful during a May 19 interview with The Associated Press.

    A day before she died, Anadith showed a fever of 104.9 degrees Fahrenheit (40.5 degrees Celsius), the CBP report said.

    A surveillance video system at the Harlingen, Texas, station was out of service since April 13, a violation of federal law that prevented evidence collection, according to the Office of Professional Responsibility, akin to a police department’s office of internal affairs. The system was flagged for repair but wasn’t fixed until May 23, six days after the girl died.

    Still, the report relied on interviews with Border Patrol agents and contracted medical personnel to raise a host of new and troubling questions about what went wrong during the girl’s nine days in custody, which far exceeded the agency’s own limit of 72 hours.

    Investigators gave no explanation for decisions that medical staff made and appeared to be at a loss for words.

    “Despite the girl’s condition, her mother’s concerns, and the series of treatments required to manage her condition, contracted medical personnel did not transfer her to a hospital for higher-level care,” the Office of Professional Responsibility said.

    Troy Miller, CBP’s acting commissioner, said the initial investigation “provides important new information on this tragic death” and he reaffirmed recent measures including a review of all “medically fragile” cases in custody to ensure they are out of custody as soon as possible. Average time in custody has dropped by more than half for families in two weeks, he said.

    “(This death) was a deeply upsetting and unacceptable tragedy. We can — and we will — do better to ensure this never happens again,” Miller said.

    Anadith entered Brownsville, Texas, with her parents and two older siblings May 9 when daily illegal crossings topped 10,000 as migrants rushed to beat the end of pandemic-related restrictions on seeking asylum.

    She was diagnosed with the flu May 14 at a temporary holding facility in Donna, Texas, and was moved with her family to Harlingen. Staff had about nine encounters with Anadith and her mother over the next four days at the Harlingen station until her death over concerns including high fever, flu symptoms, nausea and breathing difficulties. She was given medications, a cold pack and a cold shower, according to the Office of Professional Responsibility.

    A court-appointed monitor expressed concern in January about chronic conditions of medically fragile children not getting through to Border Patrol staff.

    Dr. Paul H. Wise, a Stanford University pediatrics professor who was in South Texas last week to look into the circumstances around what he said was a “preventable” death, said there should be little hesitation about sending ill children to the hospital, especially those with chronic conditions.

    Anadith’s mother told the AP that she informed staff of her child’s conditions, which included sickle-cell anemia, and repeatedly asked for medical assistance and an ambulance to take her daughter to a hospital but the request were denied until her child fell unconscious.

    Karla Marisol Vargas, an attorney for the Texas Civil Rights Project who is representing the family, said Border Patrol agents rejected her pleas for medicine until the day she died.

    “They refused to review documents showing the illnesses that her daughter had,” Vargas said.

    The family is living with relatives in New York City while funeral arrangements are made.

    ___

    Associated Press writer Elliot Spagat in San Diego contributed to this story.

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  • Hackensack Meridian Health Recognized for Excellence with ACC Chest Pain Center Accreditations

    Hackensack Meridian Health Recognized for Excellence with ACC Chest Pain Center Accreditations

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    Newswise — The American College of Cardiology has recognized all eligible Hackensack Meridian medical centers for their demonstrated expertise and commitment in treating patients with chest pain. They were recently awarded Chest Pain Center Accreditations based on rigorous onsite evaluation of the staffs’ ability to evaluate, diagnose and treat patients who may be experiencing a heart attack. 

    According to the Centers for Disease Control and Prevention, more than 730,000 Americans suffer a heart attack each year.  The most common symptom of a heart attack for both men and women is chest pain or discomfort. However, women are more likely to have atypical symptoms. Other heart attack symptoms include, but are not limited to, tingling or discomfort in one or both arms, back, shoulder, neck or jaw, shortness of breath, cold sweat, unusual tiredness, heartburn-like feeling, nausea or vomiting, sudden dizziness and fainting.

    Percutaneous coronary intervention (PCI) is also known as coronary angioplasty. It is a non-surgical procedure that opens narrowed or blocked coronary arteries with a balloon to relieve symptoms of heart disease or reduce heart damage during or after a heart attack.

    Jersey Shore University Medical Center in Neptune, NJ and JFK University Medical Center in Edison, NJ, earned ACC Chest Pain Center with Primary PCI and Resuscitation Accreditation.

    Hospitals that have received this accreditation have proven exceptional competency in treating patients with heart attack symptoms and have primary PCI available 24/7 every day of the year. As required to meet the criteria of the accreditation designation, they comply with standard Chest Pain Center protocols and are equipped with a robust hypothermia program for post-cardiac arrest treatment. These facilities also maintain a “No Diversion Policy” for out-of-hospital cardiac arrest patients.

    Hackensack University Medical Center in Hackensack, NJ; Riverview Medical Center in Red Bank, NJ; Ocean University Medical Center in Brick, NJ; Bayshore Medical Center in Holmdel, NJ and Raritan Bay Medical Center in Perth Amboy, NJ, earned ACC Chest Pain Center with Primary PCI Accreditation.  Hospitals that have received this accreditation have proven exceptional competency in treating patients with heart attack symptoms and have primary PCI available 24/7 every day of the year. As required to meet the criteria of the accreditation designation, they have streamlined their systems from admission to evaluation to diagnosis and treatment all the way through to appropriate post-discharge care and recommendations and assistance in patient lifestyle changes. In addition, they have formal agreements with other facilities that regularly refer heart attack patients to their facility for primary PCI.

    Southern Ocean Medical Center in Manahawkin, NJ, earned ACC Chest Pain Center Accreditation.  Hospitals with this accreditation have proven exceptional competency in treating patients with heart attack symptoms. They have streamlined their systems from admission to evaluation to diagnosis and treatment all the way through to appropriate post-discharge care and recommendations and assistance in patient lifestyle changes. 

    “Hackensack Meridian Health has demonstrated its commitment to providing New Jersey with excellent heart care,” said Deepak L. Bhatt, MD, MPH, FACC, chair of the ACC Accreditation Management Board. “ACC Accreditation Services is proud to award Hackensack Meridian medical centers with Chest Pain Center Accreditations.”

    Hospitals receiving Chest Pain Center Accreditations from the ACC must take part in a multi-faceted clinical process that involves: completing a gap analysis; examining variances of care, developing an action plan; a rigorous onsite review; and monitoring for sustained success. Improved methods and strategies of caring for patients include streamlining processes, implementing guidelines and standards, and adopting best practices in the care of patients experiencing the signs and symptoms of a heart attack. Facilities that achieve accreditation meet or exceed an array of stringent criteria and have organized a team of doctors, nurses, clinicians, and other administrative staff that earnestly support the efforts leading to better patient education and improved patient outcomes.

    “Depending on a variety of factors, patients experiencing a heart attack are treated with clot-dissolving drugs (thrombolysis), balloon angioplasty (PCI) and stenting, surgery or a combination of treatments,” said Elizabeth A. Maiorana, MBA, MSN, R.N., vice president, Cardiovascular Care Transformation Services, Hackensack Meridian Health.  “I’m proud of our medical centers’ cardiac teams for achieving excellence in providing these treatments, done accordingly with their licensure.” 

    For information about Hackensack Meridian’s heart care services, visit

    www.hackensackmeridianhealth.org/en/services/heart-care.  For a free physician referral, call 844-HMH-WELL.

    The ACC offers U.S. and international hospitals like Hackensack Meridian’s access to a comprehensive suite of cardiac accreditation services designed to optimize patient outcomes and improve hospital financial performance. These services are focused on all aspects of cardiac care, including emergency treatment of heart attacks.

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  • Ribosomal jam: Heartbreaking traffic

    Ribosomal jam: Heartbreaking traffic

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    Newswise — Fukuoka, Japan—A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.

    The mutation was found to delay the rate of translating mRNA, leading to ribosomes colliding and causing protein folding abnormalities. The abnormal proteins would then be targeted and degraded by the cell’s quality control system. Moreover, while the deficiency in the ribosomal protein, known as RPL3L, altered translation dynamics for the entire tissue, its effects were most pronounced for proteins related cardiac muscle contraction.

    The study, published in Nature Communications, shines new insight into the dynamics of a molecule as fundamental as ribosomes. Furthermore, since RPL3L gene deficiencies have been found in humans with cardiomyopathy and atrial fibrillation, the team hopes their new findings can lead to future treatments.

    You are likely familiar with the process of how cells produce the proteins and molecules that make the body function. DNA is transcribed into messenger RNA, or mRNA, which is then used as a blueprint to link amino acids together and build a protein. At the heart of the protein building process is the ribosome which reads the mRNA and translates that code into proteins.

    Because of its fundamental function, ribosomes are found within all cells and were thought to be generally the same. However, recent studies have revealed the existence of differences in ribosomal structures.

    “These differences in a ribosomal structure have shown to lead to translation specificity. For example, some ribosomes are better at producing proteins that control metabolism, or the cell cycle. It’s a new concept called Ribosome Heterogeneity,” explains Keiichi I. Nakayama of Kyushu University’s Medical Institute of Bioregulation who led the study. “We hypothesized that this heterogeneity exists between tissues. After screening for tissue-specific ribosomal proteins we found one that was only expressed in heart and skeletal muscle: RPL3L.”

    To elucidate the function of RPL3L, the team studied the hearts of mice with a mutated RPL3L gene. As expected, echocardiographic analysis showed that they had reduced cardiac contractility. Their next step was to study why exactly this mutation led to such a condition. As it turns out, the RPL3L mutation was causing a ‘translational traffic jam’ for proteins critical in proper heart function.

    “We found that the mutant RPL3L would delay translation for the proline and alanine codons on mRNA. This delay caused ribosomes to collide, resulting in proteins not folding correctly,” continues Nakayama. “Misfolded proteins would then be cleared out from the cell by its quality control system. More importantly, much of the misfolded proteins were ones involved in cardiac contraction.”

    The team hopes that by deepening our understanding of the translation dynamics of ribosome such as RPL3L, they can better understand how its genetic mutations—found in patients with dilated cardiomyopathy and atrial fibrillation—can lead to heart disease.

    “We are developing new understandings in the field of biology and medicine every day, even in something as fundamental as ribosomes. I’m exciting to see what we’ll find next,” concludes Nakayama.

    ###

    For more information about this research, see “RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function,” Chisa Shiraishi, Akinobu Matsumoto, Kazuya Ichihara, Taishi Yamamoto, Takeshi Yokoyama, Taisuke Mizoo, Atsushi Hatano, Masaki Matsumoto, Yoshikazu Tanaka, Eriko Matsuura-Suzuki, Shintaro Iwasaki, Shouji Matsushima, Hiroyuki Tsutsui, Keiichi I. Nakayama Nature Communicationshttps://doi.org/10.1038/s41467-023-37838-6

    About Kyushu University 
    Kyushu University is one of Japan’s leading research-oriented institutes of higher education since its founding in 1911. Home to around 19,000 students and 8,000 faculty and staff, Kyushu U’s world-class research centers cover a wide range of study areas and research fields, from the humanities and arts to engineering and medical sciences. Its multiple campuses—including one of the largest in Japan—are located around Fukuoka City, a coastal metropolis on the southwestern Japanese island of Kyushu that is frequently ranked among the world’s most livable cities and historically known as Japan’s gateway to Asia. Through its Vision 2030, Kyushu U will ‘Drive Social Change with Integrative Knowledge.’ Its synergistic application of knowledge will encompass all of academia and solve issues in society while innovating new systems for a better future.

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  • TVT 2023 Late-Breaking Science Announced

    TVT 2023 Late-Breaking Science Announced

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    Newswise — NEW YORK – May 12, 2023 – The Cardiovascular Research Foundation (CRF) announced that TVT: The Structural Heart Summit will feature 15 Late-Breaking Clinical Science studies. An annual meeting featuring cutting-edge research and techniques for structural heart interventions, TVT will take place June 7-10, 2023, at the Phoenix Convention Center – West in Phoenix, Arizona.

    TVT has become the epicenter of innovation and collaboration in the structural heart arena over its 16-year history. The meeting brings together world-renowned experts and master operators to help translate novel discoveries into practical therapies for patients with valvular heart disease.

    TVT’s late-breaking clinical science will highlight the latest advances in transcatheter aortic valve replacement as well as mitral, tricuspid, and left atrial appendage occlusion therapies. Data from these trials will help guide the selection of patients who will benefit most from these procedures and help define optimal treatment strategies, tools, and techniques for new and emerging treatments.

    Thursday, June 8, 2023

    Late-Breaking Clinical Science I

    Mitral Valve Disease

    Innovation & Clinical Science, Room 106

    11:00 AM – 12:15 PM MST

    • Contemporary, Core-Lab Assessed, Acute Clinical Outcomes from 2000+ Patients with Mitral Regurgitation Treated with the 3rd and 4th Generation MitraClip™ Systems: Results from the EXPANDed Post Approval Studies
    • Longer-Term Clinical and Echocardiography Follow-up of Transcatheter Mitral Valve Replacement with the Trans-apical Intrepid System
    • Contemporary Outcomes of Transcatheter Transeptal Mitral Valve in Valve in the United States
    • Mitral Valve Repair versus Replacement after Transcatheter Edge-to-Edge Mitral Repair: Results from The CUTTING-EDGE Registry
    • Pressure Gradients and Mortality Following Transcatheter Mitral Valve in Valve and Valve in Ring

    Friday, June 9, 2023

    Late-Breaking Clinical Science II

    Aortic Valve Disease (TAVR)

    Innovation & Clinical Science, Room 106

    11:00 AM – 12:15 PM MST

    • 5 Year Outcomes of TAVI Patients with Prosthesis-Patient Mismatch
    • Transcatheter Aortic Valve Replacement Using a Balloon-Expandable Valve in Patients with Type-0 Bicuspid Aortic Valve Stenosis
    • Real-World Early Outcomes of Evolut FX Versus PRO+ Transcatheter Aortic Valve Replacement
    • Analysis of New Permanent Pacemaker Implantation in the PORTICO NG Study Utilizing the Intra-Annular, Self-Expandable Navitor™ Transcatheter Aortic Heart Valve
    • Three-Year Outcomes from the Evolut Low Risk TAVR Bicuspid Study

    Saturday, June 10, 2023

    Late-Breaking Clinical Science III

    Early Human Experiences – Mitral Valve Replacement Innovation

    Innovation & Clinical Science, Room 106

    • Innovalve First-in-Human TMVR Experience (TWIST FIH): Clinical Outcomes and Echocardiography Evidence for Reverse Remodeling
    • Early Human Experience with the Cephea Transseptal TMVR System in Complex Mitral Anatomies
    • Bioprosthetic Surgical Valves in Intermediate-risk Patients: 1-Year Outcomes of the PARTNER 3 Mitral Valve-in-Valve Study
    • AltaValve Early Feasibility Study: Preservation of Mitral Valve Physiology Using a Passive Fixation TMVR Device
    • Trans-septal Mitral Valve Replacement with HighLife Valve in a Patient with Moderate-Severe Mitral Regurgitation

    In addition to the 15 late-breaking science studies, TVT will feature:

    • More than 30 live cases from 13 leading academic medical centers in North America and Europe
    • Six tracks: Imaging, Left Atrial Appendage (LAA)/Patent Foramen Ovale (PFO), Heart Failure, Mitral, Tricuspid, and TAVR
    • Case-based sessions and hands-on training
    • Moderated poster presentations
    • And much more!

    Additional information on TVT is available at https://tvt2023.crfconnect.com/.

    About CRF

    The Cardiovascular Research Foundation (CRF) is one of the world’s leading nonprofit organizations specializing in interventional cardiology innovation, research, and education. CRF is dedicated to helping doctors improve survival and quality of life for people suffering from heart and vascular disease. For over 30 years, CRF has helped accelerate medical breakthroughs and educated doctors on the latest treatments for heart disease. CRF’s centers of excellence include the CRF Skirball Center for Innovation, CRF Clinical Trials Center, CRF Center for Education, CRF Digital, TCTMD, and Structural Heart: The Journal of the Heart Team. For more information, visit www.crf.org.

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  • Professor and students seek to uncover Nature’s chilling secret

    Professor and students seek to uncover Nature’s chilling secret

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    Newswise — Eric Bredahl, PhD, and his team of undergraduate research assistants are trusting that Nature, if asked nicely, or at least insistently, will yield another of her secrets.

    What happens, they want to know, when hibernating animals settle in for their long winter nap? They know hibernators experience a surge of a chemical known as adenosine, that heartbeats subsequently slow dramatically — in the case of a squirrel declining from 300 beats a minute to a few beats per minute, and that the burning of sugars is replaced by the metabolism of lipids.

    But how does this extreme state of relaxation last so long without reducing muscle mass or causing heart damage through reduced blood flow, or through the damage that sometimes occurs when normal blood flow resumes?

    The answers to these questions carry important implications for the preservation and successful transplantation of a human heart on its speedy journey from donor to recipient. That journey typically takes four to five hours, during which time the heart’s temperature is lowered and metabolism slowed through the use of a chilled organ preservation solution.

    Imagine, though, that a hibernation-like process could be used to improve organ storage and double the transport window, thus allowing for a larger donor and recipient pool. The dramatic slowing of function could potentially double its transportation window to 10 or 12 hours, thus allowing residents of difficult-to-reach rural areas better accessibility to donor hearts.

    “How and why can the heart of a hibernator function at such a low temperature for such an extended period without any ill effects?” — Eric Bredahl, PhD

    “How do you keep a hibernating animal alive for four months in the absence of food without a reduction in function having any negative effects?” asks Bredahl. “Nature has evolved all these unique mechanisms, unique pathways, and the more we understand about them the more we might be able to take those same mechanisms and apply them to a clinical condition.

    “In our case, what we are really interested in is how and why the heart of a hibernator can function at such a low temperature for such an extended period without any ill effects. We have an idea of how that happens. Now we are taking those same processes and applying them to a clinical application like transporting hearts for cardiac transplant.”

    Can it be done? Bredahl is hopeful.

    “Preliminary data says it may be possible,” he says. “But we are still doing basic research. Every couple of days we add more data and more data. It’s very exciting stuff.”

    Bredahl, an associate professor in exercise science, is aided in this quest by a $112,000 grant from the Great Plains IDeA Clinical Translational Research Program. The study is formally titled “Expanding the Cardiac Transplant Window: Treatments Derived from Hibernators,” and uses rat hearts to study the response of hearts to hibernation-like influences. It is a joint project of Bredahl and Matt Andrews, PhD, professor in the School of Natural Resources at the University of Nebraska-Lincoln.

    And, of course, a group of undergraduates availing themselves of Creighton’s many opportunities for adventures in research.

    “This project would not have been possible without our undergrads,” Bredahl says. “Liz Kettler (BS’23) and Nik Johnson (BS’22), for example, put almost a year’s worth of work into this project. It is phenomenal what they did.” 

    Furthermore, this project received significant help from Frazer Heinis, a post-doctoral researcher at the University of Nebraska-Lincoln.

    The incoming cohort of undergraduate students will have similar opportunities, Bredahl said.

    “I have about seven of them, and they are going to do a whole variety of things,” he says. “Some of them will work with me on cardiac tissue doing functional assessments. Some of them will do molecular assessment where we try to quantify how much damage is happening from storage, and others will do protein analysis to see if there is any change in regulatory protein expression.

    “It will basically be groups of three, and they will have their own research project and every one of them will have something that they can present, hopefully something that they can publish and give them experience that will be second to none.”

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  • Mental illness may put people under 40 at a greater chance of heart attack and stroke | CNN

    Mental illness may put people under 40 at a greater chance of heart attack and stroke | CNN

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    CNN
     — 

    Adults in their 20s and 30s with mental disorders have a higher chance of having a heart attack or stroke, according to a new study.

    The study published Monday in the European Journal of Preventive Cardiology looked at the health data of more than 6.5 million people through the Korean National Health Insurance Service database.

    The people included in the new study ranged in age from 20 to 39 and underwent health examinations between 2009 and 2012. Their health was monitored until December 2018 for new onset heart attacks and stroke.

    About 13% of participants had some type of mental disorder — which included insomnia, anxiety, depression, somatoform disorder, post-traumatic stress disorder, substance use disorder, eating disorders, bipolar disorder, schizophrenia or a personality disorder, according to the study.

    Those people younger than 40 with a mental disorder were 58% more likely to have a heart attack and 42% more likely to have a stroke than those with no disorder, the study found.

    “We have known for some time that mental health and physical health are linked, but what I find surprising about these findings is that these links were observable at such a young age,” said Dr. Katherine Ehrlich, an associate professor of behavioral and brain sciences at the University of Georgia. Ehrlich was not involved in the research.

    Coronary arterial disease and heart attacks are rare before the age of 40, so a study as large as this one was needed to see the relationship between mental health and such an unusual occurrence in young people, she said.

    Ehrlich said she would like to know more about the physical activity and diets of the people involved to understand better if those factors have an influence on the relationship between mental health conditions and heart attack and stroke.

    “For example, if you are chronically depressed, you may struggle to maintain a healthy diet and get adequate physical activity, which might in turn increase your risk for cardiac events over time,” she said.

    But the increased risk could not be attributed to lifestyle differences alone, as the authors controlled for factors including age, sex, high blood pressure, diabetes, high cholesterol, metabolic syndrome, chronic kidney disease, smoking, alcohol, physical activity and income, the study said.

    That doesn’t mean lifestyle should be ignored, however, said study author Dr. Eue-Keun Choi, a professor of internal medicine at Seoul National University College of Medicine in South Korea.

    “While lifestyle behaviours did not explain the excess cardiovascular risk, this does not mean that healthier habits would not improve prognosis,” Choi said in a statement. “Lifestyle modification should therefore be recommended to young adults with mental disorders to boost heart health.”

    One in eight people between ages 20 and 39 studied had some sort of mental illness, meaning a substantial number of people could be predisposed to heart attack and stroke, study author Dr. Chan Soon Park, a researcher at Seoul National University Hospital in South Korea said in a statement.

    That could point to a greater need for managing psychological conditions and monitoring heart health in those at risk, Park added.

    “If we can reduce the number of people living with chronic mental illness, we may find secondary benefits in future years regarding the number of people managing cardiac-related conditions,” Ehrlich said.

    It is important to note that the findings do not show that mental illness causes heart attacks or stroke, she added. But the research does indicate a risk factor to watch out for.

    There may be benefit in preventive measures to minimize risks, Ehrlich said, which can include maintaining a healthy diet and incorporating physical activity.

    Choi recommends that people with mental health conditions receive regular checkups as well.

    These findings may also emphasize the importance of addressing loneliness, she added.

    “Many individuals with mental illness suffer from social isolation and loneliness, and for years researchers have been sounding the alarm that loneliness is detrimental for physical health,” Ehrlich said.

    “Efforts to improve social connectedness among young people may be critical to addressing the rising rates of cardiometabolic conditions in adulthood,” she added.

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  • Apixaban vs. Warfarin in Patients with an On-X Mechanical Aortic Valve

    Apixaban vs. Warfarin in Patients with an On-X Mechanical Aortic Valve

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    Newswise — Although the On-X aortic valve and apixaban have been approved for use by the U.S. Food and Drug Administration (FDA), they had not been approved to be used together. Between May 2020 and September 2022, the PROACT Xa randomized, multicenter, open-label trial compared the direct factor Xa inhibitor apixaban (Eliquis) with warfarin in patients with bileaflet carbon aortic valves.

    A total of 863 patients from 60 sites who were at least 3 months out from aortic valve replacement (AVR) were randomized 1:1 to receive apixaban 5 mg twice daily or warfarin with a target INR of 2–3. Enrolled patients had a median age of 56 years; 24% were female. Among participants, 46% had AVR in the 12 months prior to randomization, 17% had AVR along with an aortic root graft, and 16% were reoperations on the aortic valve. Most patients (93%) received 81 mg of aspirin daily with the assigned anticoagulant.

    The study was discontinued on Sept. 21, 2022, at the recommendation of the PROACT Xa Data and Safety Monitoring Board based on observed higher rate of thromboembolic events (valve thrombosis and thromboembolism) in patients randomized to apixaban than warfarin.

    Lars Svensson, MD, of the Cleveland Clinic, will present the results of this study Saturday, May, 6, at the American Association for Thoracic Surgery (AATS) 103rd Annual Meeting in Los Angeles, detailing the events that led to the discontinuation.

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    Attribution to the American Association for Thoracic Surgery (AATS) 103rd Annual Meeting is requested in all coverage.

     

    ABOUT AATS

    The American Association for Thoracic Surgery (AATS) is an international organization that encourages, promotes, and stimulates the scientific investigation of cardiothoracic surgery. Founded in 1917 by a respected group of the earliest pioneers in the field, its original mission was to “foster the evolution of an interest in surgery of the Thorax.” Today, the AATS is the premier association for cardiothoracic surgeons in the world and works to continually enhance the ability of cardiothoracic surgeons to provide the highest quality of patient care. Its more than 1,500 members have a proven record of distinction within the specialty and have made significant contributions to the care and treatment of cardiothoracic disease. Visit aats.org to learn more.

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  • Non-elective CABG Outcomes are Adversely Impacted by COVID Infection, but not by Altered Processes of Care

    Non-elective CABG Outcomes are Adversely Impacted by COVID Infection, but not by Altered Processes of Care

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    Newswise — As thoracic researchers consider the myriad effects of COVID-19, they are looking at the impacts of the disease on patients and treatments, as well as care and treatment during the pandemic. Emily Grimsley, MD, at the University of South Florida, and co-authors looked at the differential effects of COVID-19 active viral infection, viral convalescence, and altered care processes on coronary artery bypass grafting (CABG) outcomes.

    Using data from the National COVID Cohort Collaborative (N3C) about CABG cases between 2020 and 2022, the group looked at patients who had tested negative for COVID-19, tested positive less than two weeks prior to surgery (COVID-Active infection), and tested positive more than two weeks prior to surgery. For control data, they used data from the National Surgical Quality Improvement Program (NSQIP).

    The incidence of in-hospital mortality, 30-day mortality, and infectious complications were significantly higher in the COVID-Active cohort compared to the other two groups. Adjusted analyses indicated in-hospital mortality, 30- and 90-day mortality, and infectious complications were significantly greater in the COVID-Active group compared to COVID-negative patients. 

    Comparing the equivalent mortality data for pre-COVID and the N3C data for COVID-negative patients, Grimsley’s group concluded that although the processes of care were altered by the pandemic, patient mortality did not change for COVID-negative patients. Their results indicate it is the COVID-19 infection that caused worse outcomes. Per Dr. Grimsley, “Even though healthcare delivery was significantly altered during the pandemic, it did not negatively affect patient mortality after CABG. In line with various other studies, we did see that patients with active COVID-19 infection did have higher mortality than their COVID-negative counterparts.” The group proposes further study to define the optimal timing of CABG in those with recent COVID-19 infection.

    Dr. Grimsley will present the results of this study Saturday, May 6, at the American Association for Thoracic Surgery (AATS) 103rd Annual Meeting in Los Angeles.

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    Attribution to the American Association for Thoracic Surgery (AATS) 103rd Annual Meeting is requested in all coverage.

     

    ABOUT AATS

    The American Association for Thoracic Surgery (AATS) is an international organization that encourages, promotes, and stimulates the scientific investigation of cardiothoracic surgery. Founded in 1917 by a respected group of the earliest pioneers in the field, its original mission was to “foster the evolution of an interest in surgery of the Thorax.” Today, the AATS is the premier association for cardiothoracic surgeons in the world and works to continually enhance the ability of cardiothoracic surgeons to provide the highest quality of patient care. Its more than 1,500 members have a proven record of distinction within the specialty and have made significant contributions to the care and treatment of cardiothoracic disease. Visit aats.org to learn more.

     

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  • Valved Sano Shunt Improves Immediate Outcomes Following Norwood Operation for Hypoplastic Left Heart Syndrome

    Valved Sano Shunt Improves Immediate Outcomes Following Norwood Operation for Hypoplastic Left Heart Syndrome

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    Newswise — Hypoplastic left heart syndrome (HLHS) is a birth defect that affects normal blood flow through the heart. As the baby develops during pregnancy, the left side of the heart does not form correctly. The Centers for Disease Control and Prevention (CDC) estimates that each year about 1,025 babies in the United States are born with hypoplastic left heart syndrome—about one out of every 3,841 babies each year. 

    Although HLHS outcomes have improved tremendously with staged surgical palliation and the technical and management refinements incorporated over time, the overall 5-year survival rate is ~65%. Considerable Stage I perioperative and interstage morbidity and mortality remain, despite refinements of the surgical technique of the Norwood procedure. Two options used to circumvent the birth defect are the Blalock-Taussig (BT) shunt, which connects the right subclavian artery to pulmonary artery, and the Sano shunt, which connects directly from the right ventricle to the pulmonary artery. Although many centers have adopted the Sano shunt because it solves some of the weaknesses of the BT shunt physiology and improves survival outcomes, it has several shortcomings.

    David Kalfa, MD, PhD, and associates at Columbia University Medical Center hypothesized that use of the Valved Sano (VS) during the Norwood Stage I operation would improve cardiac hemodynamics, stabilize end-organ function postoperatively, reduce cardiac events and reinterventions, and boost ventricular recovery during the initial Stage I hospitalization and interstage periods. The group reviewed 25 consecutive HLHS neonates who underwent a valved Sano (VS) Stage I operation using a femoral venous homograft and 25 consecutive HLHS neonates who underwent a standard non-valved Sano (NVS) between 2014 and 2022. Primary outcomes were ventricular function, tricuspid regurgitation, end-organ function, Sano and pulmonary artery (PA) reintervention, and survival at post-operative, discharge, interstage, and pre-Glenn time points. 

    This retrospective analysis indicates that the VS was associated with improved multi-organ recovery and hemodynamic stability resulting in fewer patients experiencing cardiac events, fewer PA reinterventions before Stage II, and enhanced ventricular function recovery during initial hospitalization following the Norwood operation. These beneficial associations exist without an accompanied increase in conduit reinterventions. These promising findings warrant increased use and study of the VS during the Norwood operation.

    Dr. Kalfa will present this study Saturday, May 6, at the American Association for Thoracic Surgery (AATS) 103rd Annual Meeting in Los Angeles.

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    Attribution to the American Association for Thoracic Surgery (AATS) 103rd Annual Meeting is requested in all coverage.

     

    ABOUT AATS

    The American Association for Thoracic Surgery (AATS) is an international organization that encourages, promotes, and stimulates the scientific investigation of cardiothoracic surgery. Founded in 1917 by a respected group of the earliest pioneers in the field, its original mission was to “foster the evolution of an interest in surgery of the Thorax.” Today, the AATS is the premier association for cardiothoracic surgeons in the world and works to continually enhance the ability of cardiothoracic surgeons to provide the highest quality of patient care. Its more than 1,500 members have a proven record of distinction within the specialty and have made significant contributions to the care and treatment of cardiothoracic disease. Visit aats.org to learn more.

     

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  • Study Uncovers Post-Vaccine Heart Inflammation Risks

    Study Uncovers Post-Vaccine Heart Inflammation Risks

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    Newswise — New Haven, Conn. — When new COVID-19 vaccines were first administered two years ago, public health officials found an increase in cases of myocarditis, an inflammation of the heart muscle, particularly among young males who had been vaccinated with mRNA vaccines. It was unclear, however, what exactly was causing this reaction.

    In a new study, Yale scientists have identified the immune signature of these heart inflammation cases.

    These findings, published May 5 in the journal Science Immunology, rule out some of the theorized causes of the heart inflammation and suggest potential ways to further reduce the incidence of a still rare side effect of vaccination, the authors say.

    Myocarditis is a generally mild inflammation of heart tissue which can cause scarring but is usually resolved within days. The increased incidence of myocarditis during vaccination was seen primarily in males in their teens or early 20s, who had been vaccinated with mRNA vaccines, which are designed to elicit immune responses specifically to the SARS-CoV-2 virus.

    According to the Centers for Disease Control and Prevention (CDC), among males aged 12 to 17, about 22 to 36 per 100,000 experienced myocarditis within 21 days after receiving a second vaccine dose. Among unvaccinated males in this age group, the incidence of myocarditis was 50.1 to 64.9 cases per 100,000 after infection with the COVID-19 virus.

    For the new study, the Yale research team conducted a detailed analysis of immune system responses in those rare cases of myocarditis among vaccinated individuals. The team was led by Carrie Lucas, associate professor of immunobiology, Akiko Iwasaki, Sterling Professor of Immunobiology, and Inci Yildirim, associate professor of pediatrics and epidemiology.

    They found that the heart inflammation was not caused by antibodies created by the vaccine, but rather by a more generalized response involving immune cells and inflammation.

    “The immune systems of these individuals get a little too revved up and over-produce cytokine and cellular responses,” Lucas said.

    Earlier research had suggested that increasing the time between vaccination shots from four to eight weeks may  reduce risk of developing myocarditis.

    Lucas noted that, according to CDC findings, the risk of myocarditis is significantly greater in unvaccinated individuals who contract the COVID-19 virus than in those who receive vaccines. She emphasized that vaccination offers the best protection from COVID-19-related disease.

    “I hope this new knowledge will enable further optimizing mRNA vaccines, which, in addition to offering clear health benefits during the pandemic, have a tremendous potential to save lives across numerous future applications,” said Anis Barmada, an M.D./Ph.D. student at Yale School of Medicine, who is a co-first author of the paper with Jon Klein, also a Yale M.D./Ph.D. student.

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  • Hackensack Meridian Mountainside Medical Center Awarded Spring 2023 ‘A’ Hospital Grade from Leapfrog Group

    Hackensack Meridian Mountainside Medical Center Awarded Spring 2023 ‘A’ Hospital Grade from Leapfrog Group

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    Newswise — Montclair, NJ – (May 3, 2023) – Hackensack Meridian Mountainside Medical Center received an “A” Hospital Safety Grade from The Leapfrog Group, a national nonprofit upholding the standard of patient safety in hospitals and ambulatory surgery centers. This national distinction celebrates Mountainside Medical Center’s achievements in prioritizing patient safety by protecting patients from preventable harm and errors. The new grades reflect performance primarily during the height of the pandemic.

    “The past few years have been a challenge, but at Mountainside Medical Center never wavered in our commitment to providing safe patient care,” said Tim O’Brien, chief executive officer at Mountainside Medical Center.  “I am proud of the Mountainside team, who understand and work hard to implement patient-first practices.

    The Leapfrog Group, an independent national watchdog organization, assigns an “A,” “B,” “C,” “D” or “F” grade to general hospitals across the country based on over 30 national performance measures reflecting errors, accidents, injuries and infections, as well as systems hospitals have in place to prevent harm.

    “This new update of Hospital Safety Grades shows that, at the national level, we saw deterioration in patient safety with the pandemic,” said Leah Binder, president and CEO of The Leapfrog Group. “But this hospital received an ‘A’ despite those challenges. I congratulate all the leaders, staff, volunteers, and clinicians who together made that possible.”

    The Leapfrog Hospital Safety Grade is the only hospital ratings program based exclusively on hospital prevention of medical errors and harm to patients. The grading system is peer-reviewed, fully transparent and free to the public. Grades are updated twice annually, in the fall and spring.

    About Hackensack Meridian Mountainside Medical Center

    Newswise — Hackensack Meridian Mountainside Medical Center has been serving Montclair and its surrounding New Jersey communities since 1891. The hospital provides patients access to innovative and effective treatment in specialized centers within the hospital focused on radiology, women’s health, oncology, surgery, bariatrics, neurosciences, stroke, and cardiovascular services. Mountainside is designated as a Primary Stroke Center by The Joint Commission and The NJ State Department of Health and Senior Services and is one of only a few community hospitals licensed by the State to perform emergency cardiac angioplasty and emergency neuroendovascular procedures. To learn more about Hackensack Meridian Health Mountainside Medical Center visit www.mountainsidehosp.com.

    About The Leapfrog Group                                                                                  

    Founded in 2000 by large employers and other purchasers, The Leapfrog Group is a national nonprofit organization driving a movement for giant leaps for patient safety. The flagship Leapfrog Hospital Survey and new Leapfrog Ambulatory Surgery Center (ASC) Survey collect and transparently report hospital and ASC performance, empowering purchasers to find the highest-value care and giving consumers the lifesaving information they need to make informed decisions. The Leapfrog Hospital Safety Grade, Leapfrog’s other main initiative, assigns letter grades to hospitals based on their record of patient safety, helping consumers protect themselves and their families from errors, injuries, accidents and infections. For more, follow us on Twitter and Facebook, and sign up for our newsletter.

     

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  • Behavior Patterns of People Who Achieve Clinically Significant Weight Loss

    Behavior Patterns of People Who Achieve Clinically Significant Weight Loss

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    Newswise — COLUMBUS, Ohio – A new study analyzing data on over 20,000 U.S. adults links a healthier diet and increased exercise to weight loss that reduces heart disease risk – while associating skipping meals and taking prescription diet pills with minimal weight loss, weight maintenance or weight gain. 

    For many in the study sample, however, losing a “clinically significant” 5% of their body weight did not eliminate their risk factors for cardiovascular disease, results showed. In fact, the average composite score on eight risk factors for heart disease was the same across the entirety of the study population – regardless of reported weight changes, up or down.

    The study is the first to compare weight-loss strategies and results in the context of the American Heart Association’s “Life’s Essential 8,” a checklist promoting heart disease risk reduction through the pursuit of recommended metrics for body weight, blood pressure, cholesterol, blood sugar, smoking, physical activity, diet and sleep. The AHA first defined a construct of cardiovascular health with “Life’s Simple 7” metrics in 2010, and updated the recommendations to the “Life’s Essential 8” in June 2022. 

    The Ohio State University researchers found that overall, U.S. adults had an average score of 60 out of 100 on the eight measures – suggesting there is plenty of room for improvement even among those whose diet and exercise behaviors helped move the needle on some metrics. 

    “The Life’s Essential 8 is a valuable tool that provides the core components for cardiovascular health, many of which are modifiable through behavior change,” said senior study author Colleen Spees, associate professor of medical dietetics in the School of Health and Rehabilitation Sciences at Ohio State.  

    “Based on the findings in this study, we have a lot of work to do as a country,” she said. “Even though there were significant differences on several parameters between the groups, the fact remains that as a whole, adults in this country are not adopting the Life’s Essential 8 behaviors that are directly correlated with heart health.”

    The research was published recently in the Journal of the American Heart Association

    Data for the analysis came from 20,305 U.S. adults aged 19 or older (average age of 47) who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016. Participants reported their smoking status, physical activity, average hours of sleep per night, weight history and weight loss strategy, and what they had eaten in the previous 24 hours. Health exams and lab tests measured their body mass index, blood pressure, LDL (bad) cholesterol and blood glucose. 

    The Ohio State researchers used the data to determine individuals’ values for Life’s Essential 8 metrics and assessed their diet quality according to the Healthy Eating Index, which gauges adherence to U.S. Dietary Guidelines for Americans

    Within the sample, 17,465 individuals had lost less than 5% of their body weight, maintained their weight or gained weight in the past year. The other 2,840 reported intentional loss of at least 5% of their body weight in the same time frame.

    “Clinically significant weight loss results in improvements in some health indices,” Spees said. “People should feel hopeful in knowing that losing just 5% of their body weight is meaningful in terms of clinical improvements. This is not a huge weight loss. It’s achievable for most, and I would hope that incentives people instead of being paralyzed with a fear of failure.” 

    In this study, adults with clinically significant weight loss reported higher diet quality, particularly with better scores on intakes of protein, refined grains and added sugar, as well as more moderate and vigorous physical activity and lower LDL cholesterol than the group without clinically significant weight loss. On the other hand, the weight-loss group also had a higher average BMI and HbA1c blood sugar measure and fewer hours of sleep – all metrics that would bring down their composite Life’s Essential 8 score.

    A greater proportion of people who did not lose at least 5% of their weight reported skipping meals or using prescription diet pills as weight-loss strategies. Additional strategies reported by this group included low-carb and liquid diets, taking laxatives or vomiting, and smoking. 

    “We saw that people are still gravitating to non-evidence-based approaches for weight loss, which are not sustainable. What is sustainable is changing behaviors and eating patterns,” Spees said. 

    With federal data estimating that more than 85% of the adult U.S. population will be overweight or obese by 2030 (compared to the current rate of 73%), Spees said that to fend off related increases in heart disease and other health problems, a paradigm shift toward prevention is in order.

    “We absolutely need to be moving toward prevention of disease versus waiting until people are diagnosed with a disease. This becomes quite overwhelming, and individuals may feel it’s too late at that point,” she said. 

    One idea to consider, she said, would be prescriptions for regular visits with registered dietitians trained in behavior change, complete with insurance reimbursement – similar to physical therapy. 

    “We have fantastic research, we have incredible educators,” she said. “What we don’t have is policy that promotes optimal health across the lifespan, from pregnancy through older adulthood.”

    Co-authors of the study included first author Emily Hill (supported by a National Center for Advancing Clinical Sciences fellowship), Lauren Cubellis, Randell Wexler and Christopher Taylor.

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    Ohio State University

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  • Researchers identify cause of cancer drug-related heart damage

    Researchers identify cause of cancer drug-related heart damage

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    Newswise —

    A new study led by researchers from UCL (University College London) has found the likely reason why some cancer treatments can cause damage to the heart. This development brings safer cancer drugs one step closer.

    Modern cancer drugs are effective in treating cancer, but some of them can cause damage to the heart, known as cardiotoxicity. The damage can range from slight changes in the heart’s ability to pump blood to severe heart failure. The exact mechanisms by which these drugs cause damage have not been fully understood so far.

    A new study, supported by the British Heart Foundation, has found certain proteins in the blood that can increase the chances of developing heart diseases, including heart failure. These proteins are also affected by cancer drugs that can cause damage to the heart. The study was published in the journal Science Advances.

    The study found proteins in the blood that are connected to heart diseases and can be affected by cancer drugs, which explains how some cancer treatments damage the heart. By identifying those at risk, better cancer treatments can be developed that avoid affecting these proteins.

    The study has found new possible targets for drugs to treat heart diseases such as heart failure. These drugs could work by stopping proteins that increase the risk of developing heart diseases or by activating proteins that lower the risk.

    To begin their research, the scientists conducted a study called genome-wide association. This involved analyzing the DNA of almost 37,000 individuals who did not have heart disease and were part of the UK Biobank study. Through this analysis, they identified genetic variations that were associated with changes in the ventricles, which are the heart’s pumping chambers.

    Our genes have instructions to make proteins, which are important for the body. By analyzing the DNA of almost 37,000 people without heart disease, researchers found 33 proteins linked to the risk of developing different heart diseases. These proteins are present in the blood and are coded for by genetic variants. Some of these proteins are also targeted by cancer drugs.

    Dr. Floriaan Schmidt, the lead author from UCL Institute of Cardiovascular Science, said that the proteins identified in the study can help in developing new drugs for cancer and heart diseases. The findings can provide a blueprint for drug development, making scientists more confident in designing drugs that can shrink tumors without causing damage to the heart or improve the heart’s pumping action.

    Professor Sir Nilesh Samani from the British Heart Foundation has said that although there have been advancements in cancer treatment, there is a risk of heart damage caused by some cancer drugs.

    Professor Sir Nilesh Samani explained that this study has paved the way for the development of safer and more targeted drugs, reducing the risk of heart problems after cancer treatment. He believes that this research can help to make worries about heart damage after cancer treatment a thing of the past.

    This research was also supported by the UKRI/NIHR Multimorbidity fund Mechanism and Therapeutics Research Collaborative and the Rosetrees Trust.

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    University College London

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