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Tag: gut

  • OHSU Study: Dangerous Bacteria Stops Gut’s Infection Defense Mechanism – KXL

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    PORTLAND, OR – Research conducted as Oregon Health & Science University shows a specific strain of E. coli can block your gut’s defense against infection.

    Researchers say when bacteria associated with food poisoning, such as E. coli, invade through the digestive tract, gut cells usually fight back by pushing infected cells out of the body to stop the infection from spreading.

    According to the study, which was published recently in Nature, scientists from Genentech in collaboration with researchers from OHSU, discovered that this strain of E. coli — known for causing bloody diarrhea — is able to spread more easily with the ability to stop the body’s natural defense.

    The research shows the bacteria inject a special protein called NleL into gut cells, which breaks down key enzymes, known as ROCK1 and ROCK2, that are needed for infected cells to be expelled. Without this process, the infected cells can’t leave quickly, allowing the bacteria to spread more easily.

    Experts say, when harmful bacteria invade the gut, the body fights back quickly. Usually, the first line of defense is the intestinal lining — made up of tightly packed cells that absorb nutrients and keep bacteria out of the bloodstream. If one of these cells gets infected, it will fall from the gut lining into the intestines to be flushed. This helps prevent the bacteria from spreading.

    “This study shows that pathogenic bacteria can block infected cells from being pushed out,” said Isabella Rauch, Ph.D., senior author of the study and associate professor of molecular microbiology and immunology in the OHSU School of Medicine.

    “It’s a completely different strategy from what we’ve seen before. Some bacteria try to hide from being detected, but this one actually stops the cell’s escape route.”

    This discovery could pave the way for new treatments that target how bacteria cause disease, rather than killing the bacteria outright, like antibiotics do.

    “By understanding how bacteria bypass our body’s defenses, scientists could design anti-virulence therapies that don’t rely on antibiotics,” Rauch said. “That’s really important, especially as antibiotic resistance continues to rise.”

    A colorized electron micrograph of a cluster of E. coli bacteria is shown in this undated handout from the U.S. Department of Agriculture. Acquired Through MGN Online.

    The findings also carry global health implications. This type of E. coli can be especially dangerous for young children, whose bodies can’t handle fluid loss as well. Scientists warn that climate change and weakened food safety systems could make these infections more common.

    “These kinds of bacteria are already a serious problem in places with poor sanitation,” Rauch said. “But with rising temperatures and cutbacks in food safety monitoring, they’re becoming a growing threat in developed countries too.”

    Beyond infectious disease, the discovery could also shed light on gut disorders like IBD, where the gut lining sheds too many cells too often.

    “This cell ‘extrusion’ process happens in healthy guts all the time at a low level,” Rauch said. “But in IBD, it ramps up, and we don’t fully understand why. Similarly, we also see this in gastrointestinal cancers. This research gives us more insight into both sides of the equation, both how the body protects itself and how things go wrong.”

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    Tim Lantz

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  • ‘Gut Health’ Has a Fatal Flaw

    ‘Gut Health’ Has a Fatal Flaw

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    In my childhood home, an often-repeated phrase was “All disease begins in the gut.” My dad, a health nut, used this mantra to justify his insistence that our family eat rice-heavy meals, at the exact same time every day, to promote regularity and thus overall health. I would roll my eyes, dubious that his enthusiasm for this practice was anything more than fussiness.

    Now, to my chagrin, his obsession has become mainstream. Social-media testimonials claim that improving your “gut health” not only helps with stomach issues such as bloating and pain but also leads to benefits beyond the gastrointestinal system (easing problems including, but not limited to, itching, puffy face, slow-growing hair, low energy, acne, weight gain, and anxiety). You can now find a staggering range of products claiming to support digestive health: Joining traditionally gut-friendly fermented foods such as yogurt and sauerkraut are “probiotic” or “prebiotic” teas, cookies, gummies, supplements, powders, and even sodas.

    The reality is less straightforward. Maintaining the health of the gastrointestinal tract, like the health of any body part, is always a good idea. But expecting certain foods and products to overhaul gut health is unrealistic, as is believing that they will guarantee greater overall well-being. Those claims are “a little bit premature,” Karen Corbin, an investigator at the Translational Research Institute of Metabolism and Diabetes, told me. Obsessing over it just isn’t worth the trouble, and can even do more harm than good. “Gut health” cookies, after all, are still cookies.

    In my dad’s defense, your gut does matter for your health. A massive microbial civilization lives mostly along the large intestine, helping the body get the most out of food. Broadly, a healthy gut is one where the different segments of this population—numerous species of bacteria, fungi, and viruses—live in harmony. An unhealthy one implies a disturbance of the peace: One group may grow too powerful, or an invading microbe may throw things off-balance, leading to problems including gastroenteritis and a compromised immune system.

    Diet in particular has a profound impact on the gut—and how it subsequently makes you feel. “Food can have effects on the microbiome, which can then secondarily affect the host,” Purna Kashyap, a gastroenterologist at the Mayo Clinic, told me. The effects of food on a person and their microbes, he added, are generally congruent; fast food, for example, is “bad for both of us.” Neglect to feed your microbiome and the balance of microbes could tip into disarray, resulting in an imbalanced gut and corresponding bloating, stomach pain, and problems with bowel movements.

    Fermented foods such as yogurt and kimchi, long considered good for digestive health, are known as “probiotics” because they contain live bacteria that take up residence in your gut. Other foods are considered “prebiotic” because they feed the microbes already in your gut—mostly fiber, because it isn’t digested in the stomach. Getting more fiber improves regularity and supports a more normal GI system, Corbin said.

    But the fundamental problem with the gut-health obsession is that “there’s no clear definition of a healthy gut microbiome,” Corbin said. The makeup and balance of people’s microbiomes vary based on numerous factors, including genes, diet, environment, and even pets. This means that a treatment that works to rebalance one gut might not work for another. It also means that a product promoting a healthy gut doesn’t mean anything concrete. The idea that achieving gut health, however it’s defined, can solve stomach-related issues is misguided; many diseases can cause abdominal distress.

    Less certain is how much gut health is responsible for benefits beyond the gastrointestinal tract. No doubt the microbiome is connected to other parts of the body; recent research has suggested that it has a role in weight gain, depression, and even cancer, supporting the idea that having a healthy gut could lead to other benefits. But the mechanisms underpinning them are largely unknown. Which microbes are involved? What are they doing? There are “a lot of tall claims based on animal studies that the microbiome influences diabetes or obesity or whatever,” and the translatability of those studies to humans is “really unlikely,” Daniel Freedberg, a gastroenterologist at Columbia University, told me. Until scientists can show definitively that microbe X leads to outcome Y, Corbin said, any relationships between the gut and overall health are “just correlations.”

    None of this is to say that paying more attention to your digestive health is a bad idea. Especially for people diagnosed with gastrointestinal problems like IBS or Crohn’s disease, it can be essential. For everyone else, pursuing a healthy gut with food and supplements can be a nonspecific process with poorly defined goals. The food industry has capitalized on interest in probiotics and prebiotics—as well as lesser-known postbiotics and synbiotics—making products such as “insanely probiotic” yogurt, probiotic-fortified chocolate and spaghetti, and prebiotic sodas. Particularly with probiotics, the specifics are lacking. Which bacteria, and how many of them, actually make it past the stomach into the colon isn’t well understood. “A lot of probiotics are unlikely to contain viable bacteria, and probably very few of them are really making it through to the colon,” Freedberg said.

    Prebiotics are generally more important, although the source matters. Prebiotic fiber is “one of the most important things that determines what bacteria are there,” Freedberg told me, but getting small amounts from fiber-fortified products isn’t going to make a huge difference. The soda brands Poppi and Olipop largely contain inulin, a type of fiber that’s common in food manufacturing for its slightly sweet taste, Freedberg explained, though it probably doesn’t contain a lot, otherwise it would become “sludgy.” Olipop contains about nine grams of fiber per can, roughly the same amount as one cup of cooked lima beans.

    Of course, any product that is inherently unhealthy won’t magically become good for you the moment fiber or live bacteria are added to it. With desserts and salty snacks, no amount of fiber “is going to overcome the issue” that they are full of sugar or salt, Corbin said. Concerns about medium aside, though, gut-health products elicited a shrug from her: Buying foods containing additional prebiotic fiber is a “reasonable approach,” so long as they’re healthy to begin with. If probiotics make a patient feel “fantastic,” Freedberg said, “I’m not going to rock the boat.” Prebiotic and probiotic products may help to a degree, but don’t expect them to overhaul an unhealthy gut one soda at a time. All of the experts I spoke with said that people concerned about their gut health should eat a lot of fruits, vegetables, whole grains, and legumes, and cut out junk that won’t feed their microbiome. In other words, a basic healthy diet is more than enough to achieve good gut health.

    My dad’s gut-health mantra was apparently borrowed from Hippocrates, suggesting that people have been obsessing over the digestive system for thousands of years with the belief that it is the key to overall health. The draw of this idea is its simplicity: Proposing that the body’s many ills can be collapsed into a single mega-ailment makes treatment seem refreshingly uncomplicated compared with the medical interventions needed to address individual problems. That the proposed treatments are easy and self-administrable—sipping fibrous soda, popping bacteria-packed pills—adds to the appeal.

    But perhaps what is most compelling about the idea is that there is some truth to it. Lately, research on the microbiome has seen some promising advances. A large study published in 2022 showed significantly elevated levels of certain bacteria in people with depressive symptoms. Another study, co-authored by Corbin in 2023, was one of the first to show, in a human clinical trial, that a high-fiber diet shifts the microbiome in a way that could promote weight loss. This moment is especially confusing because we are finally beginning to understand the gut’s connections to the rest of the body, and how eating certain foods can soothe it. Much more is known about the gut than in the days of Hippocrates, but still far less than the gut influencers on social media would have you believe.

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    Yasmin Tayag

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  • 7 Reasons to Trust Your Gut in Entrepreneurship | Entrepreneur

    7 Reasons to Trust Your Gut in Entrepreneurship | Entrepreneur

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    Opinions expressed by Entrepreneur contributors are their own.

    Starting a business is an exciting but daunting prospect. You need to consider many factors when taking the plunge and deciding whether or not you can make it a success. One crucial factor that shouldn’t be overlooked is trusting your gut.

    Trusting your gut means more than just relying on instinct or being impulsive. It’s about trusting your intuition and decisions when starting a business. It’s about learning how to recognize the signs that something isn’t right and taking action accordingly rather than having an emotional reaction to every situation. Knowing how to trust your gut can help you make decisions confidently, even in uncertain times.

    Related: Should You Actually Trust Your Gut Feelings?

    Why should you trust your gut?

    1. You know what’s right for you. Every decision you make needs to be right for you and your business. While opinions from family and friends are valuable, ultimately, you should make the final call based on what you believe is best for you and your business. Only by listening to what feels right internally can you make the right decision for yourself and your venture.
    2. Recognize patterns. Experienced entrepreneurs know how to identify patterns in their businesses that signal opportunities or challenges ahead. Learning to read between the lines will help inform decisions that lead to growth and success for your business. Recognizing patterns also enables you to spot potential problems before they become too big of an issue so that issues can be addressed quickly as they arise.
    3. Make quick decisions. Trusted entrepreneurs take decisive action when faced with difficult situations rather than dwelling on them for too long or overthinking their options. This helps them move quickly from one challenge or opportunity to another without getting bogged down in analysis paralysis or second-guessing themselves due to fear of failure or change. By identifying patterns in their businesses, trusted entrepreneurs can make quick decisions with confidence that align with their core values and goals for their company without hesitation or indecision, delaying progress or putting them at risk of missing out on potential opportunities down the line due to lack of action now.
    4. Stay true to yourself. One crucial thing successful entrepreneurs understand is staying true to who they are as individuals while running their businesses regardless of external pressures from peers, industry trends, etc. Staying true allows them to remain focused on achieving their goals rather than being distracted by temporary fads or industry hype since trust relies heavily on consistency over time.
    5. Don’t get caught up in the details. Many entrepreneurs get caught up in details when starting a business instead of focusing on what matters most: the people involved in making things happen! That’s why trusted entrepreneurs prioritize relationships over tasks; they understand that building strong relationships between key stakeholders is essential for long-term success, even if it requires extra effort during tough times like start-up phases which may require everyone to work together diligently until stability sets in!
    6. Listen to advice but ignore the noise. A successful entrepreneur understands where the advice comes from before accepting it; advice from experienced professionals should be taken seriously, but input from random strangers should be ignored since chances are it might not have a basis in reality nor provide any tangible benefits, either short term or long term! That’s why trusted entrepreneurs listen carefully before acting upon feedback received because sometimes “no” is just as important as “yes”! Additionally, if the advice does come from someone reputable, then there’s no harm double checking facts provided out of precaution because mistakes can happen, so always verify information correctly before proceeding!
    7. Embrace failure. Ultimately failure happens, but it doesn’t mean destruction; failure provides valuable lessons which can help shape future decisions made by trusting entrepreneurs who embrace adversity instead of running away from it because when done correctly, failure leads us closer to our desired outcomes, not away from them due diligence coupled dedication paying off eventually if persistent enough!

    Related: Know When to Trust Your Gut and When to Seek Outside Advice

    Conclusion

    Starting a business requires courage and conviction. Trusting your gut is just one way successful entrepreneurs learn how to manage risks while navigating uncharted territory successfully!

    It’s all about learning how to recognize patterns within our environment, spotting opportunities, taking decisive actions while staying true to ourselves, never allowing outside noise to distract us and focusing solely on what matters.

    Energy is spent unnecessarily, so always trust your gut and never settle for anything less than the best. Strive higher — only then will you reap the rewards.

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    Kartik Jobanputra

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  • COVID Infection Disrupts the Gut’s Microbiome

    COVID Infection Disrupts the Gut’s Microbiome

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    By Dennis Thompson 

    HealthDay Reporter


    TUESDAY, Nov. 1, 2022 (HealthDay News) — COVID-19 is known to mess with a person’s lungs, and can have long-term effects on the brain.

    Now doctors have found another way COVID harms your health — through your gut.

    A COVID infection can reduce the number of bacterial species in the gut, creating an opportunity for dangerous antibiotic-resistant bacteria to thrive, according to a new study in the journal Nature Communications.

    “Our findings suggest that coronavirus infection directly interferes with the healthy balance of microbes in the gut, further endangering patients in the process,” said study co-senior author Ken Cadwell, a microbiologist at NYU Grossman School of Medicine in New York City.

    An unhealthy gut leaves a person vulnerable to life-threatening diarrhea from harmful bacteria like C. difficile. It also can cause other health problems like bloating and acid reflux.

    The study is the first to show that COVID alone damages the gut microbiome, researchers said. Before now, doctors had suspected that the use of antibiotics to treat COVID had been damaging gut bacteria.

    Analysis of nearly 100 men and women hospitalized with COVID in 2020 found that most patients had low gut microbiome diversity. In fact, full quarter had guts dominated by a single type of bacteria, the researchers found.

    At the same time, populations of several potentially harmful microbes increased. Some antibiotic-resistant bacteria had migrated into the bloodstream of 20% of patients.

    “Now that we have uncovered the source of this bacterial imbalance, physicians can better identify those coronavirus patients most at risk of a secondary bloodstream infection,” Cadwell said in an NYU news release.
     

    The findings were published Nov. 1.


    More information

    The Cleveland Clinic has more about gut health.

     

    SOURCE: NYU Grossman School of Medicine, news release, Nov. 1, 2022



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