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Tag: Gene

  • Gene & Georgetti’s Tony Durpetti Championed Chicago’s Restaurants

    Gene & Georgetti’s Tony Durpetti Championed Chicago’s Restaurants

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    In 1997, Gene & Georgetti unveiled an expansion with two second-floor dining rooms that grew seating at the legendary Chicago steakhouse by 110. Owner Tony Durpetti paid big bucks for fire doors that separated the newly constructed building from the original that was erected in 1872.

    Durpetti would occasionally complain about the expenditure: “That’s $90,000 I’m never going to see again,” he’d tell his daughter, Michelle.

    The spend was worth it. In 2019, a kitchen fire raged through the restaurant, shooting up flames to the second floor. Michelle Durpetti recalls the conversation she had with the fire chief at the scene. He said they were lucky — the fire doors protected the 147-year-old building and kept the damage limited to the new space. The daughter waited until her father arrived to tell him.

    “I was like, ‘Let me talk about that $90,000 you thought you were never going to see again,’” Michelle Durpetti says. “And he’s like — literally — and this was my father, this was what he said all the time when something is, say, incredulous. He looked at me, he goes: ‘No shit.’ And that was him.”

    Gene & Georgetti Tony Durpetti poses in a second-floor dining room in 2014.
    Timothy Hiatt/Eater Chicago

    For 35 years Anthony “Tony” Aldo Durpetti had been an ambassador for Chicago’s hospitality industry, maintaining Gene & Georgetti’s iconic status after purchasing the River North restaurant from his father-in-law, Gene Michelotti (who died in 1989). Michelotti and Alfredo Federighi — nicknamed “Georgetti” — founded the restaurant in 1941. Durpetti and his wife, Marion, navigated Chicago’s turbulent restaurant scene with an eye on preserving Michelotti’s legacy.

    Durpetti died on Thursday, September 26, at Northwestern Memorial Hospital in Chicago from complications due to pulmonary fibrosis and Parkinson’s disease. He was 80.

    Durpetti’s customers included locals, politicians, and celebrities including Lucille Ball, Bob Hope, Mariah Carey, and Lionel Richie. Michelle remembers an evening drinking whiskey with Russell Crowe in 2000, right after Gladiator was released. Crowe was there for a gig with his band, 30 Odd Foot of Grunts. There are no photos — Durpetti believed in leaving celebrities alone and thought pictures might make them uncomfortable.

    Michelle Durpetti dances with her father on her wedding day.
    Gene & Georgetti

    Michelle says that over the last few days, the family has received messages of support from all over the country. Before the steakhouse, her father founded a national radio advertising firm that took him all over the country — New York, Philadelphia, Cleveland, San Francisco, the Carolinas, and beyond. Born on February 1, 1944, he also served as a sergeant in the U.S. Army.

    The Durpettis have plenty of family in Italy and plan on livestreaming funeral services on Thursday, October 3, from Assumption of Catholic Church, located just across the street from the restaurant. Gene & Georgetti will be closed for lunch for a private reception and reopen for dinner at 5 p.m. Dad, who enjoyed Beefeater gin martinis, wouldn’t want to miss out on a lucrative dinner service, Michelle says.

    Working in advertising, Tony Durpetti embraced a flair for gimmicks. Michelle says her father would routinely overbook the restaurant, forcing customers to wait at the bar in waves even though they booked reservations. Online reservation systems didn’t yet exist, but a crowded bar area made Gene & Georgetti a hot spot. As Chicago’s oldest steakhouse, Durpetti took on the challenge of keeping the space relevant as more restaurants and steakhouses opened and provided more competition.

    A man posing in a photo from the ‘80s.

    A younger Tony Durpetti.
    Gene & Georgetti

    “If someone waited for like an hour for a reservation, he joked, ‘Don’t worry, I’ll get you before breakfast,’” Michelle says, though she assures customers that the restaurant ditched this practice long ago.

    In 1994, Tony helped assemble a group of steakhouses across the country, forming an alliance called the Independent Retail Cattleman’s Association. The group would seek listings in airline magazines, grabbing the attention of business-savvy fliers who needed places to empty their business accounts. This was no ranking; they split the cost of the ads and would mix up placements every so often to avoid jealousy between restaurant owners. But the exposure worked, and the business drummed up by the “association” helped Durpetti pay off the loan for expansion within six months. That acumen helped make Gene & Georgetti one of the most successful steakhouses in the country, a fixture on Restaurant Business Online’s Top 100 Independents — a list of the independent restaurants that profit the most.

    Tony Durpetti’s philosophy was one of “mindful evolution.” During the pandemic, he briefly moved to Florida where the weather was easier for a senior citizen to manage. He would call in to check on the restaurant. His daughter and her husband, Collin Pierson, had quietly transitioned into running operations years ago. Michelle would joke with her father that she wouldn’t “jazz it up” too much, but the restaurant needed to evolve, and they would add more pasta dishes, leaning more into their Tuscan heritage. As his father-in-law was unable to fly due to his health, Pierson would drive him back and forth; the last trip from Florida to Chicago came in January 2024.

    A family of four in a cart.

    Collin Pierson with Tony, Marion, and Michele Durpetti.
    Gene & Georgetti

    Pierson manages the restaurant and recalls his father-in-law’s generosity. Years ago, while he and Michelle were in Barcelona, thieves stole nearly $30,000 in photography equipment, which would have doomed Pierson’s photography business if it weren’t for his future father-in-law’s immediate gesture to pay for replacement gear.

    A couple posiing

    Tony and Marion Durpetti posed outside their River North steakhouse.
    Gene & Georgetti

    Marion and Tony Durpetti on their wedding day.
    Gene & Georgetti

    Chicago’s restaurant world is in mourning.

    “He personified class and lived a daily life of hospitality. Watching him, showed us what this business should be. He set the bar for our generation,” wrote the owners of Piccolo Sogno, one of Durpetti’s favorite restaurants, on Instagram.

    Piccolo owner and chef Tony Priolo knew Durpetti for more than 25 years. He says when he first opened, Durpetti would walk around Gene & Georgetti’s dining room telling every table to visit Piccolo Sogno: “I would call him for advice and he was up always and there for me,” Priolo says. “He was an icon to our industry, he will be greatly missed.”

    Sam Toia, president and chief executive officer of the Illinois Restaurant Association, calls Durpetti a friend and icon and that “his advocacy of the restaurant industry was surpassed only by the genuine love and warmth he showered on his family, his team, and the countless guests he welcomed to Gene and Georgetti’s.”

    Durpetti was conscious of giving opportunities to women, using the phrase “glass ceiling” in conversations with his daughter. While he was the restaurant’s public face, Michelle’s and his wife Marion’s impacts could be felt throughout. “My grandmother (Ida Passaglia) was the first bookkeeper,” Michelle says. “This was a restaurant that was always run by women — it just looked like it was run by men.”

    Michelle Durpetti says that during the height of COVID, there were times when the steakhouse could have ceased operations. The establishment was evicted by its landlord in suburban Rosemont. Her father, who battled Parkinson’s for 15 years, would occasionally visit, boosting the morale of the restaurant. Michelle says her father didn’t realize but it was his meticulous financial planning through the years that enabled the steakhouse to survive the crisis the pandemic presented.

    As she recalls her father’s legacy, Michelle remembers being 18 and challenging her father at the restaurant. She didn’t care for his overbooking policy. He promptly fired her, telling her that she could only return after she accrued enough experience to bring something positive to the table. The ordeal wasn’t scarring; it gave Michelle Durpetti perspective, and in the end, Tony Durpetti trusted his daughter and son-in-law the same way Gene Michelotti trusted him to uphold the restaurant’s legacy.

    “Most people loved my dad,” Michelle Durpetti says. “If you didn’t like my dad, it was probably on you and not on him — and I don’t even say that because he was my dad. People just gravitated to him.”

    A visitation will be held on Thursday, October 3, at Belmont Funeral Home. A Mass will be held at Assumption Catholic Church.

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    Ashok Selvam

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  • A Gene Long Thought To Just Raise The Risk For Alzheimer’s May Cause Some Cases – KXL

    A Gene Long Thought To Just Raise The Risk For Alzheimer’s May Cause Some Cases – KXL

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    WASHINGTON (AP) — For the first time, researchers have identified a genetic form of late-in-life Alzheimer’s disease.

    Most cases of the mind-robbing disease occur after age 65.

    A gene called APOE4 has long been considered a key risk factor.

    But new research says if people inherit two copies of that gene it’s not just a risk — it appears to be the underlying cause.

    About 15% of Alzheimer’s patients are thought to carry the gene pair.

    Scientists say the distinction could have implications for both research and treatment.

    The findings were published Monday in Nature Medicine.

    More about:

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    Grant McHill

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  • Bluebird Bio Stock Is in Free Fall

    Bluebird Bio Stock Is in Free Fall

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    Two weeks ago, bluebird bio secured Food and Drug Administration approval for its gene therapy for sickle cell disease, a significant milestone for the roughly 100,000 people in the U.S. who suffer from the condition.

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  • Gene That Shielded Some Against Black Death May Help, Harm People Today

    Gene That Shielded Some Against Black Death May Help, Harm People Today

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    By Cara Murez 

    HealthDay Reporter

    WEDNESDAY, March 8, 2023 (HealthDay News) — Some people may have a gene that helps protect them from respiratory diseases like COVID-19 — and helped their ancestors fight the plague.

    It comes at a cost.

    This same gene variation may be linked to an increased risk of autoimmune disease, including rheumatoid arthritis and inflammatory bowel disease, according to British researchers.

    “This gene essentially chops up proteins for the immune system,” said lead author Fergus Hamilton, a fellow at the University of Bristol.

    “Although we don’t know the exact mechanism influencing disease risk, carriers of alleles that provide more protection against respiratory disease seem to have an increased risk of autoimmune disease,” he said in a university news release. “It is potentially a great example of a phenomenon termed ‘balancing selection’ — where the same allele has different effect on different diseases.”

    Past research has found that survivors of the bubonic plague pandemic in the Middle Ages, known as Black Death, carried a variant — or allele — in a gene known as ERAP2. Those who died lacked this variant.

    The new study found that humans now have the same variants, which is associated with protection against infections such as pneumonia and COVID.

    To study this, researchers looked at infection, autoimmune disease and parental longevity across participants in three large genetic studies.

    They looked for links between variation in the ERAP2 gene and risk of autoimmune disease and infection.

    “This is a theoretical story of balance — relating to historical and contemporary disease profiles — which reflects our past and is rarely seen in real human examples,” said co-author Nicholas Timpson, a professor of genetic epidemiology at the university’s MRC Integrative Epidemiology Unit.

    Identifying links between genetics and susceptibility to disease can pave the way for potential treatments, researchers noted. It also highlights potential challenges, they said.

    While scientists are developing therapeutics to target ERAP2 for people with Crohn’s disease and cancer, it is important to consider potential effects on infection risk posed by these agents, the authors said.

    Study findings were published March 7 in the American Journal of Human Genetics. Researchers from the Universities of Edinburgh, Oxford, Cardiff, and Imperial College London also worked on the study.

    More information

    The U.S. National Library of Medicine has more on gene variants.

     

    SOURCE: University of Bristol, news release, March 7, 2023

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  • Twitter slashes its staff as Musk era takes hold on platform

    Twitter slashes its staff as Musk era takes hold on platform

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    Twitter began widespread layoffs Friday as new owner Elon Musk overhauls the company, raising grave concerns about chaos enveloping the social media platform and its ability to fight disinformation just days ahead of the U.S. midterm elections.

    The speed and size of the cuts also opened Musk and Twitter to lawsuits. At least one was filed alleging Twitter violated federal law by not providing fired employees the required notice.

    The San Francisco-based company told workers by email Thursday that they would learn Friday if they had been laid off. About half of the company’s staff of 7,500 was let go, Yoel Roth, Twitter’s head of safety & integrity, confirmed in a tweet.

    Musk tweeted late Friday that there was no choice but to cut the jobs “when the company is losing over $4M/day.” He did not provide details on the daily losses at the company and said employees who lost their jobs were offered three months’ pay as a severance.

    No other social media platform comes close to Twitter as a place where public agencies and other vital service providers — election boards, police departments, utilities, schools and news outlets — keep people reliably informed. Many fear Musk’s layoffs will gut it and render it lawless.

    Roth said the company’s front-line moderation staff was the group the least impacted by the job cuts.

    He added that Twitter’s “efforts on election integrity — including harmful misinformation that can suppress the vote and combatting state-backed information operations — remain a top priority.”

    Musk, meanwhile, tweeted that “Twitter’s strong commitment to content moderation remains absolutely unchanged.”

    But a Twitter employee who spoke with The Associated Press Friday said it will be a lot harder to get that work done starting next week after losing so many colleagues.

    “This will impact our ability to provide support for elections, definitely,” said the employee who spoke on the condition of anonymity out of concerns for job security.

    The employee said there’s no “concrete sense of direction” except for what Musk says publicly on Twitter.

    “I follow his tweets and they affect how we prioritize our work,” said the employee. “It’s a very healthy indicator of what to prioritize.”

    Several employees who tweeted about losing their jobs said Twitter eliminated their entire teams, including one focused on human rights and global conflicts, another checking Twitter’s algorithms for bias in how tweets get amplified, and an engineering team devoted to making the social platform more accessible for people with disabilities.

    Eddie Perez, a Twitter civic integrity team manager who quit in September, said he fears the layoffs so close to the midterms could allow disinformation to “spread like wildfire” during the post-election vote-counting period in particular.

    “I have a hard time believing that it doesn’t have a material impact on their ability to manage the amount of disinformation out there,” he said, adding that there simply may not be enough employees to beat it back.

    President Joe Biden, at a campaign event in Illinois Friday night, said: “Now what are we all worried about? Elon Musk, who goes out and buys an outfit that sends and spews lies all across the world. … How do we expect kids to be able to understand what is at stake?”

    Twitter’s employees have been expecting layoffs since Musk took the helm. He fired top executives, including CEO Parag Agrawal, and removed the company’s board of directors on his first day as owner.

    As the emailed notices went out, many Twitter employees took to the platform to express support for each other — often simply tweeting blue heart emojis to signify its blue bird logo — and salute emojis in replies to each other.

    A Twitter manager said many employees found out they had been laid off when they could no longer log into the company’s systems. The manager said the way the layoffs were conducted showed a “lack of care and thoughtfulness.” The manager, who spoke to the AP on the condition of anonymity out of concerns for job security, said managers were not given any notice about who would be getting laid off.

    “For me as a manager, it’s been excruciating because I had to find out about what my team was going to look like through tweets and through texting and calling people,” the employee said. “That’s a really hard way to care for your people. And managers at Twitter care a lot about their people.”

    A coalition of civil rights groups escalated their calls Friday for brands to pause advertising buys on the platform. The layoffs are particularly dangerous ahead of the elections, the groups warned, and for transgender users and other groups facing violence inspired by hate speech that proliferates online.

    In a tweet Friday, Musk blamed activists for what he described as a “massive drop in revenue” since he took over Twitter late last week.

    Insider Intelligence analyst Jasmine Enberg said there is “little Musk can say to appease advertisers when he’s keeping the company in a constant state of uncertainty and turmoil, and appears indifferent to Twitter employees and the law.”

    “Musk needs advertisers more than they need him,” she said. “Pulling ads from Twitter is a quick and painless decision for most brands.”

    A lawsuit was filed Thursday in federal court in San Francisco on behalf of one employee who was laid off and three others who were locked out of their work accounts. It alleges Twitter violated the law by not providing the required notice.

    The Worker Adjustment and Retraining Notification statute requires employers with at least 100 workers to disclose layoffs involving 500 or more employees, regardless of whether a company is publicly traded or privately held, as Twitter is now.

    The layoffs affected Twitter’s offices around the world. In the United Kingdom, it would be required by law to give employees notice, said Emma Bartlett, a partner specializing in employment and partnership law at CM Murray LLP.

    The speed of the layoffs could also open Musk and Twitter up to discrimination claims if it turns out, for instance, that they disproportionally affected women, people of color or older workers.

    ———

    AP Business Writers Mae Anderson, Alexandra Olson and Ken Sweet in New York, James Pollard in Columbia, S.C., Frank Bajak in Boston and Danica Kirka in London contributed to this story.

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  • Musk takes over Twitter and faces social media crash course

    Musk takes over Twitter and faces social media crash course

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    Twitter’s newly minted owner, the self-described “free speech absolutist” Elon Musk, is about to get a crash course on global content moderation.

    Among his first moves after completing his $44 billion takeover Thursday was to fire the social media platform’s top executives, including the woman in charge of trust and safety at the platform, Vijaya Gadde.

    He also posted a conciliatory note to wary advertisers, assuring them he won’t allow Twitter to devolve into a “free-for-all hellscape.”

    The problem is, not even the world’s richest man can have it both ways.

    Lightly moderated “free speech” sites such as Gab and Parler serve as cautionary tales of what can happen when the guardrails are lowered. These small, niche sites are popular with conservatives and libertarians fed up with what they see as censorship of their viewpoints on mainstream platforms like Facebook. They are also full of Nazi imagery, racist slurs and other extreme content, including calls to violence.

    Some conservative personalities jumped on Twitter Friday after Musk’s takeover to recirculate long-debunked conspiracy theories in an apparent attempt to see if the site’s policies on misinformation were still being enforced.

    Advertisers don’t want to promote their products next to disturbing, racist and hateful posts — and most people don’t want to spend time on chaotic online spaces where they are barraged by racist and sexist trolls.

    On Friday, GM announced it would be pausing advertising on Twitter while it figures out the direction of the platform under Musk. But Lou Paskalis, former head of media for Bank of America, said Twitter’s most loyal advertisers, many Fortune 100 companies, believe in the platform and probably won’t leave unless “some really untoward things” happen.

    But it’s not just ads and jokes that are at stake.

    Eddie Perez, a former Twitter civic integrity team leader, said Musk seems to consider Twitter a digital public square where everyone has equal voice. It’s a “quaint idea of the modern-day version of the town square,” Perez said.

    But that’s not how the major social media platforms work. They have instead become powerful tools of asymmetric warfare, and many of their users don’t realize they are being manipulated with disinformation by nation states and bad domestic actors — many with significant resources.

    “The danger here is that in the name of ‘free speech,’ Musk will turn back the clock and make Twitter into a more potent engine of hatred, divisiveness, and misinformation about elections, public health policy, and international affairs,” said Paul Barrett, deputy director of the NYU Stern Center for Business and Human Rights.

    Though he’d been expected to reinstate banned accounts — ranging from conspiracy theorist Alex Jones to Rep. Marjorie Taylor Greene — Musk said on Friday that no decisions on content or reinstatements will be made until a “content moderation council” is put in place. The council, he wrote, would have “diverse viewpoints,” but he gave no further details.

    Musk may be starting from scratch, but Twitter has spent years building up its content moderation system, which is still far from perfect. As such, experts have expressed grave concern’s about Musk’s efforts — after all, the Tesla CEO has little experience navigating the temperamental and geopolitical world of social media, even if he is a constant and wildly popular user of the site he just bought.

    “I am most concerned about Musk’s decision to summarily fire Vijaya Gadde, Twitter’s head of legal policy, trust, and safety — a senior executive who was trying, however imperfectly, to keep the platform from spreading even more harmful content than it does,” Barrett said.

    Many are looking to see if he will welcome back a number of influential conservative figures banned for violating Twitter’s rules — speculation that is only heightened by upcoming elections in Brazil, the U.S. and elsewhere.

    “I will be digging in more today,” Musk tweeted early Friday, in response to a conservative political podcaster who has complained that the platform favors liberals and secretively downgrades conservative voices.

    Former President Donald Trump, an avid tweeter before he was banned, said Friday he was “very happy that Twitter is now in sane hands” but promoted his own social media site, Truth Social, that he launched after being blocked from the more widely used platform.

    Trump was banned two days after the Jan. 6 attacks for a pair of tweets that the company said continued to cast doubts on the legitimacy of the presidential election and raised risks for the presidential inauguration that Trump said he would not be attending.

    Another task for Musk: delivering on his promise to clean up the fake profiles, or “spam bots” that have preoccupied him and bedeviled Twitter since long before he expressed interest in acquiring it.

    The bot count matters because advertisers — Twitter’s chief revenue source — want to know roughly how many real humans they are reaching when they buy ads. It’s also important in the effort to stop bad actors from amassing an army of accounts to amplify misinformation or harass political adversaries.

    ———

    Associated Press writers Frank Bajak, Jill Colvin and Mae Anderson contributed to this story. Follow AP’s coverage of Elon Musk: https://apnews.com/hub/elon-musk

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