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Tag: diagnostic imaging

  • Nobel Prize awarded for discovery of quantum dots that changed everything from TV displays to cancer imaging | CNN

    Nobel Prize awarded for discovery of quantum dots that changed everything from TV displays to cancer imaging | CNN



    CNN
     — 

    The 2023 Nobel Prize in chemistry has been awarded to a trio of scientists who worked to discover and develop quantum dots, used in LED lights and TV screens, as well as by surgeons when removing cancer tissue.

    The prize was won by Moungi Bawendi, Louis Brus and Alexei Ekimov, the Nobel committee for chemistry announced in Stockholm on Wednesday.

    “For a long time, nobody thought you could ever actually make such small particles. But this year’s laureates succeeded,” said Johan Aqvist, chair of the committee.

    The scientists were lauded as “pioneers in the exploration of the nanoworld” – in which matter starts to be measured in millionths of a millimeter. At this level, strange phenomena start to occur called “quantum effects.”

    Quantum dots consist of just a few thousand atoms. In terms of size, one quantum dot is to a soccer ball as a soccer ball is to the Earth.

    When light is passed through quantum dots they emit a specific color. This can be finely tuned and is determined by the size of the dots. The bigger dots glow red, while the smallest glow green or blue.

    The slightest of changes in the size of the particle can change its hue right across the spectrum of the color wheel.

    “We can tune these dots to fluoresce at any color that a given application requires,” Michael Edelman, CEO of UK-based quantum manufacturer Nanoco, told CNN.

    The laureates’ work has allowed scientists to capitalize on some of the properties of the nanoworld, and quantum dots are now found in living rooms and operating theaters across the world.

    They are now widely used in TVs and have several advantages over traditional LCD panels, creating more vibrant and accurate colors, as well as requiring less energy to operate.

    The dots are also widely used in medical diagnostics. Doctors use them to illuminate molecules that can bind themselves to cancer tumors, allowing the surgeon to distinguish the healthy tissue from the diseased.

    The Nobel committee explained how the scientists’ work had helped develop quantum dots.

    In the 1980s, Ekimov created size-dependent quantum effects in colored glass. “The color came from nanoparticles of copper chloride and Ekimov demonstrated that the particle size affected the color of the glass via quantum effects,” the committee said.

    A few years later, Brus became the first scientist to prove size-dependent quantum effects in particles floating freely in a liquid.

    In 1993, Bawendi then changed the chemical production of quantum dots, resulting in what the committee called “almost perfect particles.” This development allowed the dots to be used in applications.

    Bawendi, a professor at the Massachusetts Institute of Technology, and Brus, professor emeritus at Columbia University, are American. Ekimov is Russian and works for Nanocrystals Technology Inc.

    The deliberations of the Nobel committee are usually shrouded in total secrecy. No shortlists for the Nobel prizes are revealed and the winners are called shortly before the official announcement.

    But the chemistry committee inadvertently published the name of the winning trio before the official announcement on Wednesday.

    Swedish newspaper Aftonbladet published a copy of an email it said was from the academy, Reuters reported. Aqvist told Reuters ahead of the announcement that the email had been a “mistake” and stressed that a final decision had not been made. But hours later, the leaked names were confirmed as laureates.

    “Let me say that this is of course, very unfortunate. We deeply regret what happened for sure,” Hans Ellegren, secretary general of Royal Swedish Academy of Sciences, said at the announcement ceremony.

    “There was a press release sent out for still unknown reasons. We have been very active this morning to trying to find out what actually happened but at this place, we don’t know that. we deeply regret that this happened. The important thing is that it did not affect the awarding of the prize.”

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  • Top Benefits Of CBD: 7 Best CBD Products For Pain, Sleep, And Stress – Medical Marijuana Program Connection

    Top Benefits Of CBD: 7 Best CBD Products For Pain, Sleep, And Stress – Medical Marijuana Program Connection

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  • Medical imaging struggles to read dark skin. Researchers say they’ve found a way to make it easier | CNN Business

    Medical imaging struggles to read dark skin. Researchers say they’ve found a way to make it easier | CNN Business



    CNN
     — 

    Traditional medical imaging – used to diagnose, monitor or treat certain medical conditions – has long struggled to get clear pictures of patients with dark skin, according to experts.

    Researchers say they have found a way to improve medical imaging, a process through which physicians can observe the inside of the body, regardless of skin tone.

    The new findings were published in the October edition of the journal Photoacoustics. The team tested the forearms of 18 volunteers, with skin tones ranging from light to dark. They found that a distortion of the photoacoustic signal that makes the imaging more difficult to read, called clutter, increased with darkness of skin.

    “When you have darker skin, you have more melanin. And melanin is actually one of the optical absorbers that we inherently have within our body,” Muyinatu Bell, an author of the study and director and founder of the Photoacoustic and Ultrasonics Systems Engineering (PULSE) Lab at JHU, told CNN. In other words, the amount of melanin content in the skin could be associated with more clutter.

    “The skin essentially acts as a transmitter of sound, but it’s not the same type of focused sound that we get and we want with ultrasound, it’s everywhere diffused and creates a lot of confusion,” Bell said. “And so, this scattering of the sound that’s caused by the melanin absorption is worse and worse with the higher melanin concentration.”

    The study – a collaboration with researchers in Brazil who had previously used one of Bell’s algorithms – found that signal-to-noise ratio, a scientific measure that compares signal with background noise, improved for all skin tones when the researchers used a technique called “short-lag spatial coherence beamforming” while performing medical imaging. That technique, originally used for ultrasounds, can be applied to photoacoustic imaging.

    The technique involves a combination of light and ultrasound technology, forming a new medical imaging modality, Theo Pavan, an author of the study and associate professor with the department of physics at University of São Paulo in Brazil, told CNN.

    “We really verified that it was much less sensitive to the skin color in terms of the quality of the image that you can get compared to the conventional methods that … is more commonly used by the community,” Pavan said.

    The study is “the first to objectively assess skin tone and to both qualitatively and quantitatively demonstrate that skin” photoacoustic signal “and clutter artifacts increase with epidermal melanin content,” the researchers wrote.

    The applications of photoacoustic technology vary, but with the researchers’ new developments, it may help diagnose health issues more accurately and equitably.

    “Right now, it’s increasing the application of the breast imaging,” and the next step would be to “increase the image quality overall,” said Guilherme Fernandes, an author of the study and a Ph.D. candidate in physics applied to medicine and biology at USP.

    The researchers’ work could also mean advancements for equity in health care at large.

    “In our scientific technology, there is a bias in terms of developing these products, for things that work well in lighter-skinned people,” said Dr. Camara Jones, a family physician, epidemiologist and former president of the American Public Health Association, who was not involved in the new study.

    “The biggest problem is that we use a thing we call race, as a risk factor — as a health risk factor. And so race is the social and interpretation of how people look in a race-conscious society. Race is not biology,” Jones explained. “We’ve mapped the human genome. We know there’s no basis in the human genome for racial sub-speciation.”

    This study isn’t the first to find skin color biases in medical technology. Medical equipment that leverages infrared sensing has also been found to not work as well on darker skin, since skin tone can interfere with the reflection of light.

    Many devices that were in frequent use during the Covid-19 pandemic, such as pulse oximeters and forehead thermometers, involve emitting and capturing light to make a measurement. But if that device isn’t calibrated for darker skin, the pigmentation could affect how the light is absorbed and how the infrared technology works.

    Bell said her research can hopefully pave a way to eliminating discrimination in health care and inspire others to develop technology that helps everyone, regardless of their skin tone.

    “I believe that with the ability to show that we can devise and develop technology — that doesn’t just work for one small subset of the population but works for a wider range of the population. This is very inspiring for not only my group, but for groups around the world to start thinking in this direction when designing technology. Does it serve the wider population?” Bell said.

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  • What You Need To Know About Buying Wholesale CBD – Medical Marijuana Program Connection

    What You Need To Know About Buying Wholesale CBD – Medical Marijuana Program Connection

    Get ready for a truth bomb – buying wholesale CBD is a lot like stepping into a labyrinth, except instead of mythical creatures, you’re navigating through a maze of laws, testing, and quality checks. This isn’t a simple trip to the grocery store where you casually toss items into your shopping cart. Oh no, this is a strategic mission, a chess game if you will, and you’re aiming for checkmate.

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    You’ve Made Up Your Mind to Buy CBD

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    Purchase CBD the Right Way

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    Don’t let the legal jargon intimidate you. It’s just a way to ensure that you’re…

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  • Breast density changes over time could be linked to breast cancer risk, study finds | CNN

    Breast density changes over time could be linked to breast cancer risk, study finds | CNN



    CNN
     — 

    Breast density is known to naturally decrease as a woman ages, and now a study suggests that the more time it takes for breast density to decline, the more likely it is that the woman could develop breast cancer.

    Researchers have long known that women with dense breasts have a higher risk of breast cancer. But according to the study, published last week in the journal JAMA Oncology, the rate of breast density changes over time also appears to be associated with the risk of cancer being diagnosed in that breast.

    “We know that invasive breast cancer is rarely diagnosed simultaneously in both breasts, thus it is not a surprise that we have observed a much slower decline in the breast that eventually developed breast cancer compared to the natural decline in density with age,” Shu Jiang, an associate professor of surgery at Washington University School of Medicine in St. Louis and first author of the new study, wrote in an email.

    Breast density refers to the amount of fibrous and glandular tissue in a person’s breasts compared with the amount of fatty tissue in the breasts – and breast density can be seen on a mammogram.

    “Because women have their mammograms taken annually or biennially, the change of breast density over time is naturally available,” Jiang said in the email. “We should make full use of this dynamic information to better inform risk stratification and guide more individualized screening and prevention approaches.”

    The researchers, from Washington University School of Medicine in St. Louis and Brigham and Women’s Hospital in Boston, analyzed health data over the course of 10 years among 947 women in the St. Louis region who completed routine mammograms. A mammogram is an X-ray picture of the breast that doctors use to look for early signs of breast cancer.

    The women in the study were recruited from November 2008 to April 2012, and they had gotten mammograms through October 2020. The average age of the participants was around 57.

    Among the women, there were 289 cases of breast cancer diagnosed, and the researchers found that breast density was higher at the start of the study for the women who later developed breast cancer compared with those who remained cancer-free.

    The researchers also found that there was a significant decrease in breast density among all the women over the course of 10 years, regardless of whether they later developed breast cancer, but the rate of density decreasing over time was significantly slower among breasts in which cancer was later diagnosed.

    “This study found that evaluating longitudinal changes in breast density from digital mammograms may offer an additional tool for assessing risk of breast cancer and subsequent risk reduction strategies,” the researchers wrote.

    Not only is breast density a known risk factor for breast cancer, dense breast tissue can make mammograms more difficult to read.

    “There are two issues here. First, breast density can make it more difficult to fully ‘see through’ the breast on a mammogram, like looking through a frosted glass. Thus, it can be harder to detect a breast cancer,” Dr. Hal Burstein, clinical investigator in the Breast Oncology Center at Dana-Farber Cancer Institute, who was not involved in the new study, said in an email. “Secondly, breast density is often thought to reflect the estrogen exposure or estrogen levels in women, and the greater the estrogen exposure, the greater the risk of developing breast cancer.”

    In March, the US Food and Drug Administration published updates to its mammography regulations, requiring mammography facilities to notify patients about the density of their breasts.

    “Breast density can have a masking effect on mammography, where it can be more difficult to find a breast cancer within an area of dense breast tissue,” Jiang wrote in her email.

    “Even when you take away the issue of finding it, breast density is an independent risk factor for developing breast cancer. Although there is lots of data that tell us dense breast tissue is a risk factor, the reason for this is not clear,” she said. “It may be that development of dense tissue and cancer are related to the same biological processes or hormonal influences.”

    The findings of the new study demonstrate that breast density serves as a risk factor for breast cancer – but women should be aware of their other risk factors too, said Dr. Maxine Jochelson, chief of the breast imaging service at Memorial Sloan Kettering Cancer Center in New York, who was not involved in the study.

    “It makes sense to some extent that the longer your breast stays dense, theoretically, the more likely it is to develop cancer. And so basically, it expands on the data that dense breasts are a risk,” Jochelson said, adding that women with dense breasts should ask for supplemental imaging when they get mammograms.

    But other factors that can raise the risk of breast cancer include having a family history of cancer, drinking too much alcohol, having a high-risk lesion biopsied from the breast or having a certain genetic mutation.

    For instance, women should know that “density may not affect their risk so much if they have the breast cancer BRCA 1 or 2 mutation because their risk is so high that it may not make it much higher,” Jochelson said.

    Some ways to reduce the risk of breast cancer include keeping a healthy weight, being physically active, drinking alcohol in moderation or not at all and, for some people, taking medications such as tamoxifen and breastfeeding your children, if possible.

    “Breast density is a modest risk factor. The ‘average’ woman in the US has a 1 in 8 lifetime chance of developing breast cancer. Women with dense breasts have a slightly greater risk, about 1 in 6, or 1 in 7. So the lifetime risk goes up from 12% to 15%. That still means that most women with dense breasts will not develop breast cancer,” Burstein said in his email.

    “Sometimes radiologists will recommend additional breast imaging to women with dense breast tissue on mammograms,” he added.

    The US Preventive Services Task Force – a group of independent medical experts whose recommendations help guide doctors’ decisions – recommends biennial screening for women starting at age 50. The task force says that a decision to start screening earlier “should be an individual one.” Many medical groups, including the American Cancer Society and Mayo Clinic, emphasize that women have the option to start screening with a mammogram every year starting at age 40.

    “It’s also very clear that breast density tends to be highest in younger women, premenopausal women, and for almost all women, it tends to go down with age. However, the risk of breast cancer goes up with age. So these two things are a little bit at odds with each other,” said Dr. Freya Schnabel, director of breast surgery at NYU Langone’s Perlmutter Cancer Center and professor of surgery at NYU Grossman School of Medicine in New York, who was not involved in the new study.

    “So if you’re a 40-year-old woman and your breasts are dense, you could think about that as just being really kind of age-appropriate,” she said. “The take-home message that’s very, very practical and pragmatic right now is that if you have dense breasts, whatever your age is, even if you’re postmenopausal – maybe even specifically, if you are postmenopausal – and your breasts are not getting less dense the way the average woman’s does, that it really is a reason to seek out adjunctive imaging in addition to just mammography, to use additional diagnostic tools, like ultrasound or maybe even MRI, if there are other risk factors.”

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