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Tag: Covid-19 testing

  • Elizabeth Holmes Isn’t Fooling Anyone

    Elizabeth Holmes Isn’t Fooling Anyone

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    Elizabeth Holmes isn’t fooling anyone. Well, almost anyone.

    The convicted fraudster and founder of the defunct medical start-up Theranos, is waiting to begin an 11-year sentence in federal prison. She received this punishment for misleading investors about her lab-in-a-box technology, which she claimed could run hundreds of tests on a few drops of blood. In reality, when Theranos’s Edison device wasn’t exploding, it was delivering unreliable results to frightened patients. Holmes’s fall from grace—she was once the youngest self-made woman billionaire—has been described over and over again. But there’s still a little more blood left in this stone.

    On Sunday, The New York Times ran a profile of Holmes—which included the first interview she’s given since 2016. The author, Amy Chozick, suggests that she was charmed by Holmes, the devoted family woman. Chozick writes that Holmes is “gentle and charismatic,” and “didn’t seem like a hero or a villain. She seemed, like most people, somewhere in between.” This flattering or at least ambivalent tone was not well received. The Axios editor Sam Baker picked the article apart on Twitter. The emergency-medicine physician Jeremy Faust called it “credulous drivel.” Journalists and doctors alike argued that the Times had erred by helping Holmes rehabilitate her image.

    When mistakes happen in the health-care system, doctors try to trace their origin to broken processes. Errors are addressed at the system—not individual—level: If a patient receives an incorrect dose of a medicine, for instance, the blame doesn’t necessarily fall on the nurse who administered it or the physician who prescribed it. The entire drug-delivery process, from pharmacy to bedside, is carefully inspected for unsafe practices. The media—and their content-delivery process—have been going through a similar postmortem over the Theranos debacle. Before John Carreyrou broke the bad news about the company at The Wall Street Journal, reporters were happy to write flattering profiles of Holmes with only the most rudimentary caveats. Even the Journal praised her before it damned her. But the Times’ latest visit to Holmesville suggests that this unsafe practice is still in place.

    As a pathologist—a doctor who specializes in laboratory testing—I’ve been following the Theranos story since the beginning. Holmes’s rise and fall is the most glamorous scandal to hit my field in some time: Most are more body-parts-in-the-back-of-a-pickup than celebrity-stuffed financial crimes. Just last week, I was giving a grand-rounds talk about Theranos. Loopholes in laboratory regulation and widespread ignorance of how blood testing works had caused medical professionals and the public to fall for diagnostic scams, I told the academics in attendance. Toward the end of the lecture, I posed a question: Have the media learned their lesson after enabling Holmes’s charade?

    Much has changed about science reporting in the years since Holmes’s disgrace. I’ve watched the media’s discussion of novel health technologies grow more nuanced and leery. Major news outlets now go out of their way to emphasize the precariousness of early study findings. I’ve been getting more calls from journalists who seek a skeptical perspective on some new lab test or scientific finding. But there are cracks in the media’s armor. The weakest component is the headline: You can still declare all manner of decisive breakthroughs, as long as you append “scientists find” to the title. Another persistent problem is that medical controversies are reported out study by study. Back-and-forth articles about contested areas offer ready-made drama but little clarity. (Masks help prevent COVID; wait, they don’t work at all; never mind, now they do again.) When doctors evaluate the latest research, we recognize that some methods are more reliable than others. Wisdom comes from learning which results to ignore, and scientific consensus changes slowly.

    But journalists’ most stubborn instinct—the one they share with Holmes—is to lean into a good story. It’s the human side of science that attracts readers. Every technical advance must be contextualized with a tale of suffering or triumph. Holmes knew this as well as anyone. She hardly dwelled on how her devices worked—she couldn’t, because they didn’t. Instead, she repeatedly told the world about her fear of needles and of losing loved ones to diseases that might have been caught earlier by a convenient blood test. Of course reporters were taken in. The next entrepreneur to come along and tell a tale like that may also get a sympathetic hearing in the press.

    Holmes understood that almost everyone—journalists, investors, patients, doctors—can be swayed by a pat narrative. She’s still trying to get ahead by telling stories. In offering herself up to the Times as a reformed idealist and a wonderful mother, Holmes adds to a story that was started by her partner, Billy Evans. As part of Holmes’s sentencing proceedings last fall, Evans wrote a multipage letter to the judge pleading for mercy, which was accompanied by numerous photos of Holmes posing with animals and children. “She is gullible, overly trusting, and simply naive,” Evans wrote about one of the great corporate hucksters of our era.

    Journalists are still telling stories about her too, for better or for worse. Holmes is not naive, nor are most readers of The New York Times. While last weekend’s “a hero or a villain” coverage may be said to have betrayed the patients who were harmed by her inaccurate blood tests, and the memory of a Theranos employee who died by suicide, it is also just another entry in the expanded universe of Holmes-themed entertainment. There are books and podcasts and feature-length documentaries. A TV miniseries about Holmes has a score of 89 percent on Rotten Tomatoes. (“Addictively engrossing!” “Consistently entertaining!”) Surely some of those who now bemoan the Times’ friendly treatment have consumed this material for less-than-academic reasons.

    The prosaic details of a convicted cheat’s domestic life aren’t really news, but they are interesting—because the character of Elizabeth Holmes is interesting. So, too, are her continued efforts to spin a narrative of who she is. But with such well-trodden ground, the irony is built right in. You know that Holmes is a scammer. I know it. On some level, The New York Times seems to know it too; the article runs through her crimes and even quotes a friend of Holmes’s who says she isn’t to be trusted. This isn’t character rehabilitation; it’s content. We’re all waiting to see what Liz gets up to next. Have the media learned their lesson? The real test will arrive when the next scientific scammer comes along, and the one after that—when their narrative is still intact, and their fraud hasn’t yet been revealed. At that point, the system for preventing errors will have to do its work.

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    Benjamin Mazer

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  • COVID-19 Testing in Schools Done Right: Grapefruit Testing’s Nationwide Group of 100+ Doctors Reaches 50,000 Summer Campers With No-Cost Testing

    COVID-19 Testing in Schools Done Right: Grapefruit Testing’s Nationwide Group of 100+ Doctors Reaches 50,000 Summer Campers With No-Cost Testing

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    Grapefruit’s Simple & Sweet approach to COVID-19 testing has reached thousands. Now, they are using their team of ER and public health physicians to provide grant-supported COVID-19 consulting to schools across the country.

    Press Release



    updated: Aug 8, 2021

    Grapefruit Testing has risen to become one of the most recognized names in COVID-19 testing for summer camps and educational institutions. After completing more than 50,000 tests and amassing an astounding team of more than 160 emergency medicine physicians, Grapefruit’s name is not the only thing they are garnering attention for.

    (50,000 tests) is just the beginning. We are humbled to have built a system that goes well beyond providing a test for communities. We empower schools to have the peace of mind that few- if any- medical groups offer. The turn-key approach to tailoring a response strategy to the community is how we see Grapefruit as the unique, best-in-class partner for schools. Having your own consulting public health physician to coordinate on-site, pre-arrival, or response testing is just the beginning. We have a physician on call for schools to interface with at all times, can assist with promoting vaccination within in the community, and work directly with local stakeholders to implement a customized response plan to combat COVID-19 in schools.

    – Richard Pescatore, DO, FACEP, FAAEM,  Medical Director, Grapefruit Medical

    Dr. Pescatore explained that more recently, with the spike in the variants and transmissions in younger populations, the team is receiving dozens of calls requesting consulting as to how to best respond. Many schools are requesting help with use of the  American Rescue Plan (ARP) Elementary and Secondary School Emergency Relief Fund (ESSER) support. Grapefruit continues to serve the community as an effective leader responding to COVID-19 in K-12 schools. They are the only school solutions partner for the School Superintendents Association (AASA) that specializes in COVID-19 testing and consulting.

    The organization’s nationwide footprint continues to grow. They are currently adding more school partners as of August 2021. They do not charge outside of ESSER grant support or the CARES Act Providers Relief Fund.

    To become a partner, please reach out to the team at schools@grapefruithealth.net.

    More information on the company can be found at www.grapefruittesting.com.

    Source: Grapefruit Testing

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  • BillionToOne Announces Groundbreaking New COVID-19 Test Unlocking One Million Daily Tests

    BillionToOne Announces Groundbreaking New COVID-19 Test Unlocking One Million Daily Tests

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    Unique Testing Protocol From Precision Diagnostics Company Unlocks One Million Tests Per Day: The BillionToOne COVID-19 test uses different sets of instruments and chemicals from existing COVID-19 tests, enabling labs to unlock a new set of unused capacity.

    Press Release



    updated: Apr 7, 2020

    9​The precision diagnostics company BillionToOne today announced a significant development in the struggle against the COVID-19 pandemic. BillionToOne has developed a highly accurate and cost-effective novel COVID-19 test protocol, unlocking more than one million testing capacity per day in the United States alone. Test reagents will be available in two weeks, pending manufacturing of kits and EUA from the FDA.

    “We’ve all seen the impact this pandemic has had on every aspect of our daily lives,” Dr. Oguzhan Atay, the CEO of BillionToOne, said. “From the loss of lives to the damage to the economy to the strain on the healthcare system, the coronavirus has delivered a crippling blow to the country. We’re honored to be on the front lines of this fight against the pandemic, and we’re certain that this unique technology will help save lives and stop the spread of the virus.”

    As detailed by leading health professionals, extensive testing – over 10 times the current capacity – is needed to stop the spread of the coronavirus in the United States and other countries. At the present moment, current quantitative PCR (qPCR) methods do not support the testing volume needed for rapid COVID-19 response. Additionally, the extreme surge in demand for the same reagents and instruments have caused multiple bottlenecks in the supply chain.

    Using the patent-pending qSanger™ spike-in and proprietary machine learning algorithms, BillionToOne’s COVID-19 assay takes advantage of the 30X higher throughput Sanger sequencing capacity (1,536 samples on qSanger at a time vs 48 samples on qPCR at a time). qSanger™ technology unlocks each Sanger instrument to automatically perform 3,840 tests per day, and there are hundreds of instruments available from the Human Genome Project alone, unlocking millions of testing capacity per day.

    The BillionToOne COVID-19 test uses different sets of instruments and chemicals from existing COVID-19 tests, enabling labs to unlock a new set of unused capacity. BillionToOne sequences the virus’ genome – making the test extremely sensitive and specific, on par or better than other COVID-19 tests available. Additionally, the test is easily adoptable at any labs with Sanger Sequencers, with minimum training.

    Test reagents will be available in two weeks, pending manufacturing of kits and EUA from the FDA. International laboratories without EUA requirements can start testing immediately by using their own reagents and the BillionToOne’s bioinformatics pipeline.

    “I’m extremely grateful to the hard work and dedication of the BillionToOne team to get this vital resource developed so quickly,” Oguzhan said. “Our mission here at BillionToOne is to remove the fear of the unknown by making powerful molecular diagnostics available to all. We believe our COVID-19 test can contribute greatly in removing the unknowns from the COVID-19 crisis response.”

    About BillionToOne

    BillionToOne, headquartered in Menlo Park, California, is a precision diagnostics company with a mission to make molecular diagnostics more accurate, efficient, and accessible for all. The company’s patent-pending QCT molecular counter platform is the only technology platform that can accurately count DNA molecules to the single-count level. BillionToOne’​s first product, UNITY, is the first and only noninvasive prenatal screening that tests fetal cell-free DNA for cystic fibrosis (CF) and spinal muscular atrophy (SMA) through a single sample of the mother’s blood. BillionToOne was co-founded by Oguzhan Atay, Ph.D., and David Tsao, Ph.D. For more information, visit www.billiontoone.com.

    Inquiries:

    For any questions regarding partnership and test adoption, please contact covid19@billiontoone.com. 

    For any media inquiries, contact media@billiontoone.com. 

    General Contact: Oscar Cabot, Head of Marketing ocabot@Billiontoone.com

    Source: BillionToOne, Inc.

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