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  • The Only Pet Supplement Harnessing Sialic Acid for Pet Health | Animal Wellness Magazine

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    Discover the many benefits of sialic acid for pet health and the only supplement using glyconutrients for skin and coat health, vitality, and more!

    Dog and cat parents understand the value of pet supplements that contain functional ingredients with proven benefits. Supplements of this kind are used to support mobility, cognition, healthy aging, energy, and overall health. And what if there were a functional ingredient that did it all? Sounds too good to be true, right? Glyconutrients like sialic acid have wide-ranging advantages for pet health, but only MIRANEST has found a potent natural source of sialic acid and harnessed it into a powerful pet supplement that supports skin and coat health, digestion, energy, healthy aging, and so much more!

    What Does Sialic Acid Do for the Body?

    Sialic acid is one of the eight essential glyconutrients, specialized sugars the body relies on for cellular repair and regeneration. These sugars are fundamental components of cell membranes and help cells communicate so the body can heal and function properly. Sialic acid also helps activate mitochondria, the tiny power plants inside cells that convert nutrients into ATP, the energy required for nearly every biological process. In addition, glyconutrients like sialic acid stimulate growth factors such as filaggrin and IGF-1.

    Using Sialic Acid for Pet Health Supports Total Body Health

    Skin and Coat

    By stimulating filaggrin and IGF-1, sialic acid reinforces the skin barrier and nourishes hair follicles. And by improving nutrient delivery at the cellular level, it also enables the body to heal from within and:

    • Supports hair regrowth
    • Soothes itching and redness
    • Manages hot spots
    • Reduces allergy symptoms and dandruff
    • Stops excessive shedding

    Muscle Health

    By activating mitochondria, glyconutrients like sialic acid boost cellular energy, support muscle repair and regeneration, and help maintain strength, stamina, and healthy muscle function as the body ages.

    Pain and Mobility

    Sialic acid also supports pain relief and mobility by improving cellular energy, reducing inflammation, promoting tissue repair, and supporting healthy joints, muscles, and connective tissues. This helps dogs and cats move more comfortably and stay active longer.

    Cognition

    Thanks to sialic acid’s ability to support cellular communication, including between neurons, it has neuroprotective properties and contributes to cognitive function and long-term brain health.

    Immunity

    Another role of sialic acid is helping form glycocalyx, the protective outer layer of cells that regulates immune signaling and inflammatory responses. In other words, sialic acid helps regulate inflammation, strengthen immune responses, and protect against pathogens.

    The Best Source of Sialic Acid for Pet Health

    You can find small amounts of sialic acid in foods like organ meats, colostrum, royal jelly, and some dairy products. However, most commercial pet diets are lacking in this important nutrient. Fortunately, one Japanese company has harnessed nature’s most potent source of sialic acid to create a powerful skin and coat solution for dogs and cats. MIRANEST uses a cruelty-free, bio-sustainable swiftlet nest extract paired with healing plant-based ingredients to promote vitality, skin and coat health, hot spots, allergies, joints and mobility, immunity, gut health, and whole-body health. Trusted by more than 100,000 pet parents and pet professionals worldwide, 93% of pet parents see results in as little as 30 days!

    Visit MIRANEST to learn more about sialic acid for pet health and their 100% natural pet products that support health without drugs, steroids, or side effects!

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    Animal Wellness is North America’s top natural health and lifestyle magazine for dogs and cats, with a readership of over one million every year. AW features articles by some of the most renowned experts in the pet industry, with topics ranging from diet and health related issues, to articles on training, fitness and emotional well being.

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    Animal Wellness

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  • How Jogging Slows Aging (The Effects of Running on the Aging Process) – Southwest Journal

    How Jogging Slows Aging (The Effects of Running on the Aging Process) – Southwest Journal

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    Jogging offers several health benefits, such as better cardiovascular health, effective weight management, and a lower risk of metabolic syndrome.

    It’s defined as running at a pace slower than 6 miles per hour.

    Some studies suggest that jogging might also slow aging and contribute to a longer, healthier life.

    In this article, we’ll explore the science behind how jogging can decelerate aging.

    We’ll also discuss a few additional strategies that can help older adults maintain their health.

    The Effects of Running on The Aging Process

    New research highlights the incredible benefits of jogging in the combat of the aging process. In fact, scientists revealed a fascinating correlation between high activity levels and the reversal of biological age.

    A study from Brigham Young University by Larry A. Tucker, shed light on the deep impact of running on our cells. More specifically, the impact of running on telomeres. If you’re not familiar with biochemistry, telomeres are protective sheaths at the end of chromosomes that shrink with age. As a result, their ability to shield our chromosomes diminishes, which leaves our cells vulnerable to dysfunction and demise.[1]

    Surprisingly, the study concluded that 30 to 40 minutes of running, five days a week, could be enough to turn back the cellular clock by a whopping nine years!

    But why does running greatly impact the cellular clock? The answer may lie in its ability to combat oxidative stress. You see, oxidative stress is notorious for accelerating the shortening of telomeres. Therefore, it significantly accelerates the aging process.

    The study’s findings serve as a reminder that when it comes to slowing down aging, bouts of irregular exercise will not be enough. Instead, you need to have sustained and dedicated effort. It’s those 30 to 40 minutes of rhythmic activity that’s repeated over the course of five days that truly hold the key to making your cells younger.

    More research

    According to a recent study published in the International Journal of Environmental Research & Public Health by the same Larry A. Tucker, 75 minutes of running a week can potentially extend your lifespan by as much as 12 years. The study also focused on telomeres.

    The study examined 4,458 participants, which revealed a notable difference in the biological age of runners who clocked at least 75 minutes of running per week compared to those who ran less than 10 minutes. Although the study did not directly measure mortality rates, it highlighted the significance of cellular aging since reduced telomere length has been linked to higher mortality and increased risk of chronic diseases.

    Study also focused on the concept of “healthspan.” This refers to the duration of one’s life lived without disabling chronic diseases. Numerous studies showed that cardio exercise significantly improves healthspan by reducing the chances of Alzheimer’s disease, cancer, and an array of other diseases. [2]

    Indirect Ways that Running Can Help with The Aging Process

    Better weight management

    Paul T. Williams say that as we age, it is very challenging to maintain a healthy weight. However, a healthy body mass index becomes even more critical for your well-being and longevity. Although various forms of exercise contribute to weight management, research highlights the effectiveness of running in this regard.[3]

    The transition from low-intensity activities, such as walking, to jogging will help you maintain a healthy weight and slow down the aging process, as excess weight is a key factor in accelerated aging and age-related diseases.

    Stronger immune system

    Immunosuppression is one of the hallmarks of the aging process. This is why we see more infections in elderly adults. Furthermore, the severity of the infection is also proportional to the age of the patient. In other words, the older the patient, the more likely they are to experience severe or life-threatening infections.

    John P Campbell indicates that moderate exercise can optimize the function of the immune cells and mitigate the risk related to their dysfunction. This is indispensable to maintain your vitality and resilience against illnesses that commonly afflict older adults. [4]

    Lower risk of metabolic syndrome

    indicates that regular jogging can reduce insulin resistance, which could slow down the aging process. The improvement of insulin sensitivity and metabolic health places running as the cheapest and most effective way to fight against age-related metabolic disorders.

    Note that many elderly adults deal with metabolic syndrome, including type 2 diabetes. The hallmark of the latter is insulin resistance.

    What’s more, chronically elevated blood sugar levels damage capillaries and nerves in the brain, which can considerably accelerate the aging process. [5] [6]

    Improved cognitive abilities

    Cognitive decline is a common feature of aging that affects memory, decision-making, and mental acuity. Running can be a potent intervention to preserve cognitive function as we age.

    Jogging can protect you from age-related cognitive decline through the following mechanisms:

    • Promotion of neuroplasticity.
    • Enhancement of executive function.
    • Protection against the effects of stress on the brain.

    Although these processes may not have a direct impact on telomeres, they surely address one critical aspect of the aging process – Cognitive Decline.

    Lower risk of mood disorders

    Regular jogging exerts potent antidepressant effects and provides a holistic approach to combat age-related mental health challenges. The reduction of stress hormones (e.g., cortisol) and the promotion of endorphin release are prevalent mechanisms.

    You might wonder how the antidepressant effects of running can slow down aging. Well, we have science to back us up. According to a study from 2019, of Alessio Squassina found that mood disorders, including depression, are associated with increased biological age of the cells. [7]

    Bottom Line

    Running is a fantastic physical activity that offers an array of health benefits. T

    he exciting research about running and the aging process should get us all to go out for a jog or at least hop on the treadmill.

    We hope that this article managed to explain how running can slow down the aging process and help older individuals to be healthier.

    REFERENCES:

    1. Larry A. Tucker,
      Physical activity and telomere length in U.S. men and women: An NHANES investigation,
      Preventive Medicine, Pages 145-151, ISSN 0091-7435, https://doi.org/10.1016/j.ypmed.2017.04.027.
    2. Blackmon CM, Tucker LA, Bailey BW, Davidson LE. Time Spent Jogging/Running and Biological Aging in 4458 U.S. Adults: An NHANES Investigation. International Journal of Environmental Research and Public Health. 2023; 20(19):6872. https://doi.org/10.3390/ijerph20196872
    3. Williams PT. Greater weight loss from running than walking during a 6.2-yr prospective follow-up. Med Sci Sports Exerc. 2013 Apr;45(4):706-13. doi: 10.1249/MSS.0b013e31827b0d0a. PMID: 23190592; PMCID: PMC4067491.
    4. Campbell JP, Turner JE. Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan. Front Immunol. 2018 Apr 16;9:648. doi: 10.3389/fimmu.2018.00648. PMID: 29713319; PMCID: PMC5911985.
    5. Lin X, Zhang X, Guo J, Roberts CK, McKenzie S, Wu WC, Liu S, Song Y. Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2015 Jun 26;4(7):e002014. doi: 10.1161/JAHA.115.002014. PMID: 26116691; PMCID: PMC4608087.
    6. https://www.cdc.gov/diabetes/library/features/diabetes-and-your-brain.html
    7. Squassina A, Pisanu C, Vanni R. Mood Disorders, Accelerated Aging, and Inflammation: Is the Link Hidden in Telomeres? Cells. 2019 Jan 15;8(1):52. doi: 10.3390/cells8010052. PMID: 30650526; PMCID: PMC6356466.

     

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    Srdjan Ilic

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  • Life Is Worse for Older People Now

    Life Is Worse for Older People Now

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    Last December, during a Christmas Eve celebration with my in-laws in California, I observed what I now realize was the future of COVID for older people. As everyone crowded around the bagna cauda, a hot dipping sauce shared like fondue, it was clear that we, as a family, had implicitly agreed that the pandemic was over. Our nonagenarian relatives were not taking any precautions, nor was anyone else taking precautions to protect them. Endive spear in hand, I squeezed myself in between my 94-year-old grandfather-in-law and his spry 99-year-old sister and dug into the dip.

    We all knew that older people bore the brunt of COVID, but the concerns seemed like a relic from earlier in the pandemic. The brutal biology of this disease meant that they disproportionately have fallen sick, been hospitalized, and died. Americans over 65 make up 17 percent of the U.S. population, but they have accounted for three-quarters of all COVID deaths. As the death count among older people began to rise in 2020, “a lot of my patients were really concerned that they were being exposed without anyone really caring about them,” Sharon Brangman, a geriatrician at SUNY Upstate University Hospital, told me.

    But even now, three years into the pandemic, older people are still in a precarious position. While many Americans can tune out COVID and easily fend off an infection when it strikes, older adults continue to face real threats from the illness in the minutiae of their daily life: grocery trips, family gatherings, birthday parties, coffee dates. That is true even with the protective power of several shots and the broader retreat of the virus. “There is substantial risk, even if you’ve gotten all the vaccines,” Bernard Black, a law professor at Northwestern University who studies health policy, told me. More than 300 people still die from COVID each day, and the overwhelming majority of them are older. People ages 65 and up are currently hospitalized at nearly 11 times the rate of adults under 50.

    Compounding this sickness are all the ways that, COVID aside, this pandemic has changed life for older adults. Enduring severe isolation and ongoing caregiver shortages, they have been disproportionately harmed by the past few years. Not all of them have experienced the pandemic in the same way. Americans of retirement age, 65 and older, are a huge population encompassing a range of incomes, health statuses, living situations, and racial backgrounds. Nevertheless, by virtue of their age alone, they live with a new reality: one in which life has become more dangerous—and in many ways worse—than it was before COVID.


    The pandemic was destined to come after older Americans. Their immune systems tend to be weaker, making it harder for them to fight off an infection, and they are more likely to have comorbidities, which further increases their risk of severe illness. The precarity that many of them already faced going into 2020—poverty, social isolation and loneliness, inadequate personal care—left them poorly equipped for the arrival of the novel coronavirus. More than 1 million people lived in nursing homes, many of which were densely packed and short on staff when COVID tore through them.

    A major reason older people are still at risk is that vaccines can’t entirely compensate for their immune systems. A study recently published in the journal Vaccines showed that for vaccinated adults ages 60 and over, the risk of dying from COVID versus other natural causes jumped from 11 percent to 34 percent within a year of completing their primary shot series. A booster dose brings the risk back down, but other research shows that it wears off too. A booster is a basic precaution, but “not one that everyone is taking,” Black, a co-author of the study, told me. Booster uptake among older Americans for the reengineered “bivalent” shots is the highest of all age groups, but still, nearly 60 percent have not gotten one.

    For every COVID death, many more older people develop serious illness. Risk increases with age, and people older than 70 “have a substantially higher rate of hospitalizations” than those ages 60 to 69, Caitlin Rivers, an epidemiologist at Johns Hopkins University, told me. Unlike younger people, most of whom fully recover from a bout with COVID, a return to baseline health is less guaranteed for older adults. In one study, 32 percent of adults over 65 were diagnosed with symptoms that lasted well beyond their COVID infection. Persistent coughs, aches, and joint pain can linger long after serious illness, together with indirect impacts such as loss of muscle strength and flexibility, which can affect older people’s ability to be independent, Rivers said. Older COVID survivors may also have a higher risk of cognitive decline. In some cases, these ailments could be part of long COVID, which may be more prevalent in older people.

    Certainly, some older adults are able to make a full recovery. Brangman said she has “old and frail” geriatric patients who bounced back after flu-like symptoms, and younger ones who still experience weakness and fatigue. Still, these are not promising odds. The antiviral Paxlovid was supposed to help blunt the wave of old people falling sick and ending up in the hospital—and it can reduce severe disease by 50 to 90 percent. But unfortunately, it is not widely used; as of July, just a third of Americans 80 or older took Paxlovid.

    The reality is that as long as the virus continues to be prevalent, older Americans will face these potential outcomes every time they leave their home. That doesn’t mean they will barricade themselves indoors, or that they even should. Still, “every decision that we make now is weighing that balance between risk and socialization,” Brangman said.


    Long before the pandemic, the threat of illness was already very real for older people.  Where America has landed is hardly a new way of life but rather one that is simply more onerous. “One way to think about it is that this is a new risk that’s out there” alongside other natural causes of death, such as diabetes and heart failure, Black said. But it’s a risk older Americans can’t ignore, especially as the country has dropped all COVID precautions. Since Christmas Eve, I have felt uneasy about how readily I normalized putting so little effort into protecting my nonagenarian loved ones, despite knowing what might happen if they got sick. For older people, who must contend with the peril of attending similar gatherings, “there’s sort of no good choice,” Black said. “The world has changed.”

    But this new post-pandemic reality also includes insidious effects on older people that aren’t directly related to COVID itself. Those who put off nonemergency visits to the doctor earlier in the pandemic, for example, risked worsening their existing health conditions. The first year of the pandemic plunged nearly everyone into isolation, but being alone created problems for older adults that still persist. Before the pandemic, the association between loneliness and higher mortality rates, increased cardiovascular risks, and dementia among older adults was already well established. Increased isolation during COVID amplified this association.

    The consequences of isolation were especially profound for older adults with physical limitations, Naoko Muramatsu, a community-health professor at the University of Illinois at Chicago, told me. When caregivers or family members were unable to visit, people who required assistance for even the smallest tasks, such as fetching the mail and getting dressed, had no options. “If you don’t walk around and if you don’t do anything, we can expect that cognitive function will decline,” Muramatsu said; she has observed this firsthand in her research. One Chinese American woman, interviewed in a survey of older adults living alone with cognitive impairment during the pandemic, described the debilitating effect of sitting at home all day.“I am so useless now,” she told the interviewer. “I am confused so often. I forget things.”

    Even older adults who have weathered the direct and indirect effects of the pandemic still face other challenges that COVID has exacerbated. Many have long relied on personal caregivers or the staff at nursing facilities. These workers, already scarce before the pandemic, are even more so now because many quit or were affected by COVID themselves. “Long-term care has been in a crisis situation for a long time, but it’s even worse now,” Muramatsu said, noting that many home care workers are older adults themselves. Nursing homes nationwide now have nearly 200,000 fewer employees compared with March 2020, which is especially concerning as the proportion of Americans over age 65 explodes.

    Older people won’t have one single approach to contending with this sad reality. “Everybody is trying to figure out what is the best way to function, to try to have some level of everyday life and activity, but also keep your risk of getting sick as low as possible,” Brangman said. Some of her patients are still opting to be cautious, while others consider this moment their “only chance to see grandchildren or concerts or go to family gatherings.” Either way, older Americans will have to wrestle with these decisions without so many of their peers who have died from COVID.

    Again, many of these people did not have it great before the pandemic, even if the rest of the country wasn’t paying attention. “We often don’t provide the basic social support that older people need,” Kenneth Covinsky, a clinician-researcher at the UCSF Division of Geriatrics, said. Rather, ageism, the willful ignorance or indifference to the needs of older people, is baked into American life. It is perhaps the main reason older adults were so badly affected by the pandemic in the first place, as illustrated by the delayed introduction of safety precautions in nursing homes and the blithe acceptance of COVID deaths among older adults. If Americans couldn’t bring themselves to care at any point over the past three years, will they ever?

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    Yasmin Tayag

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  • Study Confirms Memory, Concentration Issues After Lyme Disease

    Study Confirms Memory, Concentration Issues After Lyme Disease

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    Nov. 15, 2022 – People who have been treated for Lyme disease, but continue to have symptoms, have changes in their brains that confirm the memory and concentration problems many of them have reported, a new study has found. 

    Many people with what’s known as post-treatment Lyme disease – or PTLD – complain about problems with memory and concentration, which sometimes come with fatigue, muscle pain, insomnia, and depression. 

    To understand potential changes in brain function that might explain these cognitive difficulties, researchers used specialized imaging techniques to compare the brains of 12 adults with PTLD and 18 adults with no history of Lyme disease. 

    The researchers found changes in the white matter of the brains of those with PTLD. White matter is found in the deeper brain tissues and contains nerve fibers that are extensions of nerve cells.

    “We found that … white matter function increased while participants with PTLD were performing a cognitive task,” says lead investigator Cheri Marvel, PhD, an associate professor of neurology and psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine in Baltimore.

    “I think if patients heard this, they might feel validated that there is a biologic basis for their persistent symptoms, even if there is no good way to treat the cognitive difficulties yet,” she says. This may be similar to what patients with long COVID experience, Marvel says.

    The study was published online Oct. 26 in the journal PLOS One.

    ‘We Could Begin to Connect the Dots’

    “Objective biologic measures” of PTLD symptoms “typically can’t be identified using regular MRIs, CT scans, or blood tests,” senior author John Aucott, MD, director of the Johns Hopkins Lyme Disease Clinical Research Center, said in a news release.

    Because of the number of people affected by this condition — 10%-20% of the nearly half a million Americans who contract the disease each year — the researchers felt they needed to “expand” the evaluation methods.

    “We were motivated by the persistent complaints of cognitive difficulties by patients who have been treated for their Lyme disease, with a lack of data to explain the reason behind these symptoms,” Marvel says.

    It seemed logical “that if there were cognitive and neurological symptoms involved, then the brain may reveal something about this. Then we could begin to connect the dots between the patient experience and the underlying mechanisms driving them,” she says.

    To investigate, Marvel’s team used functional magnetic resonance (fMRI), an imaging technique that measures blood flow to areas of the brain, often while specific tasks are performed — in this case, short-term memory tasks that involved memorizing and recalling capital and lowercase letters as well as the alphabetical order of multiple letters.

    Those with PTLD performed more slowly on some of the memory tasks, although their slower speed did not affect the accuracy of their performance.

    The researchers found unusual activity in the white matter of the frontal lobe — an area of the brain involved in cognitive tasks, such as memory recall and concentration — in the PTLD group. 

    Typically, this type of tissue sees less blood flow, compared to gray matter in the brain, and is responsible for moving information around the brain and “delivering” it to the gray matter. The amount of activity they saw “is unusual to observe with the MRI methods we used, and we did not see such activity in the healthy control group,” Marvel says. 

    Sign of Healing?

    To confirm the finding, the investigators used a second imaging technique called diffusion tensor imaging in all 12 PTLD patients and 12 of the 18 people without PTLD.  The imaging technique detects whether there is water moving within the brain tissue and what direction it goes. 

    In the patients with PTLD, the researchers found what’s called axon diffusion – or leakage – from the white matter was tied to better brain function. The water that was diffusing was found in the same white matter regions that the first imaging test had identified.

    “This led us to speculate that the white matter changes are a healthy response to Lyme disease’s effect on the brain,” Marvel says. She suggests that the increased white matter leakage “may be a marker of healing during PTLD and represent a healthier outcome.”

    In the meantime, the researchers want to work with other experts to answer their remaining questions, she says. 

    “It is important for clinicians to know that PTLD leads to real, quantifiable brain changes and that patients’ cognitive complaints may be a direct consequence of these brain changes, rather than a side effect of other symptoms, such as fatigue, for example,” Marvel said. 

    Commenting on the study for this report, John Keilp, PhD, an associate professor of clinical psychology at Columbia University in New York City, says it is an “important, carefully executed study that expands upon earlier brain imaging studies of patients with PTLD” using “state-of-the-art brain imaging and analysis methods.”

    The researchers “have shown us a way forward to examine these patients and this disorder in greater detail as we attempt to unlock the uncertainties surrounding the physiological basis of these patients’ symptoms,” says Keilp, who heads the neuropsychology laboratory in the division of Molecular Imaging and Neuropathology at the New York State Psychiatric Institute.

     

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