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Tag: Cognitive Decline

  • Semaglutide fails to slow progression of Alzheimer’s in highly anticipated trials, Novo Nordisk says

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    An oral version of semaglutide, the active ingredient in blockbuster drugs Ozempic and Wegovy, failed to slow the progression of Alzheimer’s disease in closely watched trials, Novo Nordisk said Monday.In two Phase 3 trials of more than 3,800 adults receiving standard care for Alzheimer’s, the company evaluated whether an older pill form of semaglutide worked better than a placebo. The drug was shown to be safe and led to improvements in Alzheimer’s-related biomarkers, the company said, but the treatment did not delay disease progression.Novo had long treated Alzheimer’s as a long-shot bet for the popular GLP-1 drugs. Use of these drugs for diabetes and weight loss has exploded in recent years, and they have shown benefits for a wide range of additional health conditions, such as protecting the heart and kidneys, reducing sleep apnea and potentially helping with addiction.Smaller trials and animal studies had suggested GLP-1s might help slow cognitive decline or reduce neuro-inflammation but larger trials like Novo’s were needed to confirm whether patients saw actual benefits.”Based on the significant unmet need in Alzheimer’s disease as well as a number of indicative data points, we felt we had a responsibility to explore semaglutide’s potential, despite a low likelihood of success,” said Martin Holst Lange, chief scientific officer and executive vice president of Research and Development at Novo Nordisk said in a statement on Monday that thanked trial participants.A one-year extension of the trials will be discontinued, Novo said. Results from the trials have not yet been peer-reviewed or published but will be presented at upcoming scientific conferences.Novo has been facing increased competition in the weight loss market and recently announced lowered prices for some cash-paying patients using Ozempic and Wegovy. Novo shares fell Monday after the Alzheimer’s trial announcement.

    CNN —

    An oral version of semaglutide, the active ingredient in blockbuster drugs Ozempic and Wegovy, failed to slow the progression of Alzheimer’s disease in closely watched trials, Novo Nordisk said Monday.

    In two Phase 3 trials of more than 3,800 adults receiving standard care for Alzheimer’s, the company evaluated whether an older pill form of semaglutide worked better than a placebo. The drug was shown to be safe and led to improvements in Alzheimer’s-related biomarkers, the company said, but the treatment did not delay disease progression.

    Novo had long treated Alzheimer’s as a long-shot bet for the popular GLP-1 drugs. Use of these drugs for diabetes and weight loss has exploded in recent years, and they have shown benefits for a wide range of additional health conditions, such as protecting the heart and kidneys, reducing sleep apnea and potentially helping with addiction.

    Smaller trials and animal studies had suggested GLP-1s might help slow cognitive decline or reduce neuro-inflammation but larger trials like Novo’s were needed to confirm whether patients saw actual benefits.

    “Based on the significant unmet need in Alzheimer’s disease as well as a number of indicative data points, we felt we had a responsibility to explore semaglutide’s potential, despite a low likelihood of success,” said Martin Holst Lange, chief scientific officer and executive vice president of Research and Development at Novo Nordisk said in a statement on Monday that thanked trial participants.

    A one-year extension of the trials will be discontinued, Novo said. Results from the trials have not yet been peer-reviewed or published but will be presented at upcoming scientific conferences.

    Novo has been facing increased competition in the weight loss market and recently announced lowered prices for some cash-paying patients using Ozempic and Wegovy. Novo shares fell Monday after the Alzheimer’s trial announcement.

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    November 24, 2025
  • Study Finds Cannabis Users Have Lower Chance of Cognitive Decline | High Times

    Study Finds Cannabis Users Have Lower Chance of Cognitive Decline | High Times

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    The use of cannabis was associated with lower rates of subjective cognitive decline (SCD), according to the findings of a new study from researchers affiliated with the State University of New York (SUNY). The research found that participants who use marijuana for recreational or medicinal purposes reported less confusion and memory loss compared to those who do not use weed. 

    The new study, which was published online last month by the journal Current Alzheimer Research, found that recreational cannabis use had the most significant impact on cognitive decline.

    “Compared to non-users,” the authors wrote, “non-medical cannabis use was significantly associated with 96% decreased odds of SCD,” according to a report from Filter.

    People who used cannabis for medicinal reasons or for both recreational and medical purposes also showed “decreased odds of SCD.” However, the differences did not rise to the level of statistical significance.

    The authors of the study note that previous research has found a link between heavy cannabis use and cognitive performance. Past studies have shown that frequent or heavy marijuana use was associated with lower verbal recall performance, subjective memory complaints and lower cognitive function, among other signs of mental decline.

    “However, the cognitive implications of cannabis are not only determined by the frequency of cannabis consumption,” the researchers wrote, adding that other factors including the particular product used, method of consumption, and reason for use could also “impact the cognitive effects associated with cannabis use.”

    “Our study addresses these knowledge gaps by comprehensively examining how reason, frequency, and method of cannabis use are associated with SCD among US middle-aged and older adults,” the authors of the study added.

    To conduct the study, researchers at SUNY Upstate Medical University in Syracuse, New York analyzed health survey data from the 2021 Behavioral Risk Factor Surveillance System (BRFSS). The researchers note that the system’s cognitive decline model “was restricted to respondents aged 45 years and older in Washington DC and 14 US states (GA, HI, MS, OR, PA, TN, TX, WI, CO, MD, MI, OH, OK, and NY).”

    The total sample included 4,744 observations with valid SCD responses.

    Survey Asked About Memory Lapses And Confusion

    The survey asked respondents, “During the past 12 months, have you experienced confusion or memory loss that is happening more often or is getting worse?” Respondents were given the option to reply yes, no, don’t know/not sure, or to refuse the question.

    The researchers analyzed the survey data based on three cannabis variables including frequency of use over the past month, ranging from zero to 30 days; reason for cannabis use, which included non-user, medical, non-medical or both; and the method of cannabis consumption, such as non-user, smoke, eat, drink, vaporize, dab or other.

    “We found that non-medical cannabis use was significantly associated with reduced odds of SCD in comparison to non-users,” the researchers wrote, adding that there are several possible reasons for the study’s findings.

    The researchers offered several possible reasons that could explain why cannabis use was associated with reduced rates of self-reported cognitive decline. They note that many people use cannabis to help them sleep, citing a recent study that found that “more frequent sleep disturbances were associated with higher dementia risk in a national US older adult sample.”

    “Several studies have found that cannabis use might enhance sleep quality, expedite sleep onset, and reduce sleep disturbances. Non-medical cannabis use could have contributed to the observed decrease in SCD due to its potential benefit on sleep quality,” the discussion section of the new paper said.

    The results of the study were not consistent for some variables, however. Researchers found an association between the method of cannabis consumption, including a higher prevalence of SCD among cannabis smokers. The research also found an association between the frequency of use and cognitive decline.

    “Although increased frequency and different methods of cannabis use showed positive associations with SCD, these relationships were not statistically significant.”

    The researchers stressed that the study does not refute previous research that has shown frequent or heavy marijuana use was associated with cognitive decline. Instead, they said that the mixed findings indicate the need for further research on the subjects.

    “Our findings underscore the importance of considering multiple factors, such as the reasons for cannabis use, when examining the relationship between cannabis and SCD,” the authors wrote in their conclusion. “Further research is needed to explore the underlying mechanisms contributing to these associations.”

    The authors noted several limitations to the study, including a reliance on self-reported data. They also reported possible bias in responses from participants in states that have not legalized medical cannabis, noting that “individuals in such states may be more likely to underreport or misreport their cannabis use.”

    The study was published as an “article in press,” indicating that it has been accepted by the journal and copyedited and formatted for publication. Further corrections or proofreading changes could come before the article’s final version is published.

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    A.J. Herrington

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    March 6, 2024
  • 6 Aspects Of A Balanced Person: A Complete Picture of Well-Being

    6 Aspects Of A Balanced Person: A Complete Picture of Well-Being

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    What are the six aspects of a balanced person? Physical, mental, emotional, social, work/financial, and meaning/spiritual. Learn more about each one and how to improve it!


    In life, there isn’t one single area that we need to focus on that is going to magically fix all of our problems.

    Instead there are multiple dimensions behind every “good life.” Each dimension requires our attention and each contributes to our overall happiness and well-being.

    Here are six aspects of life that come together to create a “balanced person.” By being more aware of these different dimensions in life, we can determine which areas we need to focus on more and work to improve.

    The different aspects of a balanced person include: 1) Physical, 2) Mental, 3) Emotional, 4) Social, 5) Work/Financial and 6) Meaning/Spiritual.

    If we focus too much on any one area, then we risk neglecting another one. For example, if you become solely focused on just work and money, you may end up spending less time taking care of your physical and mental health, or less quality time with family and friends.

    This is a common trap people fall into. They focus all of their energy and effort into one area in life while completely ignoring another. Often they need to reconfigure their core values and priorities before making a meaningful change.

    This is why practicing balance in all things is so important.

    Each of these areas is one piece of a much larger puzzle, and only when you have all of these areas working together harmoniously can you finally build a complete life that serves all of your needs.

    Here’s a detailed breakdown of each aspect of a “balanced person,” along with tips, tools, and practical advice on how you can start improving each one.

    While reading ask yourself, “Which aspect do I need to focus on the most right now? What’s one small change I can make to improve that area?”

    Now let’s dive in…

    1. PHYSICAL WELL-BEING

    health

    The “physical” aspect of life is all about taking care of our health, especially exercise, diet, and sleep.

    This includes what types of foods and drinks we consume on a daily basis, how often we exercise and keep our bodies moving, personal hygiene and cleanliness, as well as minimizing alcohol, smoking, and other harmful habits to our physical health.

    Our body is one of the most precious gifts we have – and without it we can’t exist. If we don’t stay healthy, we often can’t fully enjoy all the other aspects of life such as family, work, traveling, or leisure.

    Our health can often have a spillover effect into all the other aspects of our lives – for that reason, taking care of our physical health is often an essential first step on any road to self-improvement.

    No matter what the current state of our health is, it’s never too late to start changing our habits, even if it’s something small like stretching in the morning, taking daily walks outside, or starting an active hobby like Yoga, marathon running, or playing sports.

    A healthy body is a healthy mind. When we take better care of our bodies, we also feel more confident, motivated, and energized overall. That’s the beginning of bringing out your best self.


    Things to do:

    • Identify small ways to be more physically active. Often our days are filled with opportunities to be more active, we just need to take advantage of them. Try to cultivate an “everything counts” mindset when it comes to exercise, even if it just means taking a walk around the block, or stretching in the morning, or doing push-ups before lunch. Any physical activity is better than none at all – so seek out small and convenient ways to keep your body moving throughout the day. If you find yourself sitting for long periods of time, get up and do chores, take a walk around the office, or make a phone call while standing up. A sedentary lifestyle is one of the biggest risk factors when it comes to poor health, so finding any reason to stand up more is better than sitting.
    • Find exercise that “clicks” with you and your personality. Different things work for different people. Some people need to commit themselves to a gym membership to get themselves off the couch, while others prefer to work out in the comfort of their own homes. Your personality shapes what exercise you like, so it’s important you find activities that resonate and “click” with you, rather than trying to force yourself to do something you really don’t enjoy. All you need is that one hobby to take your fitness to the next level, whether it be finding an enjoyable sport (like Tennis, or Baseball, or Basketball), or even exercising through video games (such as Wii Fit or Dance Dance Revolution). Try to think of physical activities you enjoyed as a kid, that can often be a good place to rekindle motivation.
    • Keep a healthy and consistent sleep schedule. Sleep is one of the most important habits when it comes to your overall physical and mental health. Research shows that those who don’t get sufficient sleep (between 6-10 hours every night) often suffer worse health outcomes like a weaker immune system, higher risk of obesity, lower energy and stamina, and more stress and anxiety. If your sleep habits aren’t healthy or consistent, it will likely have a negative “ripple effect” on almost every other aspect of your day. When you’re tired and fatigued, you’re more likely to make mistakes at work or argue with your spouse. It’s important not only to get between 6-10 hours of sleep each night, but also to maintain a consistent schedule. If you don’t sleep much on the weekends, it’s difficult to “catch up” on those lost hours throughout the week. Try to go to bed and wake up around the same time each day if possible. Here are more important lessons behind a good night’s sleep, including recognizing that some people are natural “early birds” or “night owls,” and that’s something you need to recognize and work with.
    • Pay attention to your food and diet. There are many different diets out there to choose from – and people can have long debates about which one is better – but the most important thing is to not eat too much, especially junk food, fast food, soda, sweets, and lots of processed food. Use your commonsense. Experiment with different diet changes and see what works best for you. Different diets work better for different people – so there’s no “one size fits all” solution to what exactly you should eat or not eat. One simple diet change is to substitute all your soda/juice/sugary drinks with water instead. Drinking plenty of water is never a bad place to start – most people don’t recognize how dehydrated they can be throughout the day and how it effects them. If you’re trying to lose weight, one popular option you can consider is intermittent fasting where you allow yourself to eat for an 8 hour window each day and fast for the remaining 16 hours. You can also try the “One Meal A Day” approach, where you restrict yourself to just one big meal (with minimal snacking). In general, pay attention to how your body responds to the things you eat: What foods leave you tired and feeling like crap? What foods make you energized and feeling good?
    • Take care of personal hygiene and cleanliness. Proper hygiene is another important aspect of physical health. While it can seem like commonsense, basic habits like taking a shower, brushing your teeth, getting a haircut, trimming your nails, and washing your face are are all important things not to neglect. Not only does cleanliness prevent you from catching germs and getting sick, you also feel better about yourself when you present yourself in the best way possible (and smell good). Often we are surprised by how much better we feel after a fresh new haircut, or clean new clothes, or new cologne/perfume. When mental health is low, we sometimes neglect these basic habits out of laziness or apathy, which is why they are a crucial first step in self-improvement if we aren’t paying enough attention to them.
    • Minimize your bad habits. No one is 100% perfect and we all have a couple bad habits, whether it be eating too many sweets, or drinking alcohol, or staying up late, or smoking cigarettes. In general, it’s important to quit (or minimize) our unhealthy habits as much as possible. “Choose your crutches wisely.” Keep in mind the long-term consequences of your habits – while it may not feel like they are hurting you right now, their effects can often catch up to you in the future. When trying to quit any bad habit, identify your triggers and work from there to change to change your patterns. Often by creating more boundaries between you and your bad habits, you can overcome your urge to do them (until it’s no longer an automatic habit anymore). If you find that you have a serious problem with addiction or drug abuse, consider professional help (such as a therapist, psychologist, or counselor) – there are often local resources available in your area if you do a quick search.

    Please don’t underestimate the importance of keeping your body in the best shape possible. As Socrates famously said, “No man has the right to be an amateur in the matter of physical training. It is a shame for a man to grow old without seeing the beauty and strength of which his body is capable.”

    Physical health is about much more than just looking and feeling good about yourself – it’s about living a life of vitality and longevity. You can have everything else in your life figured out, but if you don’t maintain your health you won’t be around very long to use or enjoy it.

    2. MENTAL WELL-BEING

    mental

    If you don’t take care of your body then it will slowly deteriorate – and the same is true for your mind.

    Just because you don’t have to go to school anymore doesn’t mean you can’t keep learning new things, keeping your brain sharp, and challenging your intellect.

    Reading books. Learning about new topics. Having deep conversations. Attending lectures and workshops. Following the news. These are all commonsense ways to keep our minds active and continue to update our knowledge and belief system as we move through life.

    Learning is a lifelong endeavor. Balanced people are always seeking new things to dig into and learn more about like a new hobby, new game, or new skill such as painting, chess, learning a new language, or playing a musical instrument.

    In addition, research shows that continuing to challenge our brain is an important way to prevent cognitive decline as we get older, including lower the risk of dementia and memory loss.


    Things to do:

    • Read more books. Reading is one of the best ways to keep your mind sharp and learn new things. Nonfiction books about science, history, philosophy, or self help can grow your knowledge and broaden your perspective on life; and reading fiction has been shown to have many cognitive benefits such as boosting empathy, creative thinking, and expanding your vocabulary. If you haven’t read a book in awhile, try to make it a goal to read at least one book this year. You can start with a book you already own but never got a chance to read, or ask a friend for a book recommendation, or get a card from your local library and explore countless books for free. Find a topic or subject that interests you and start there!
    • Learn a new skill. Learning multiple skills is a hallmark of being a balanced and well-rounded person. It’s never too late in life to dive into something completely new, such as playing a musical instrument, learning a new language, writing poetry, painting, or playing chess. A jack of all trades mindset can make you stand-out from others in unique ways. Many people have a talent or passion for at least one thing, but when you start combining talents and cultivating multiple interests it shows your range and flexibility as a person. Don’t limit yourself. There’s no pressure to become a “professional” or “expert” in everything you do, just stay on a learning path, have fun while doing it, and enjoy seeing the growth as you go.
    • Watch documentaries. Documentaries are a fun and easy way to explore new topics and learn about interesting things you otherwise wouldn’t experience. Depending on what you like, there are many different subjects to choose from: history, sports, biographies, science, inspirational stories, or nature documentaries (which have also been shown to boost positive emotions like joy, gratitude, and awe). I’ve made a lengthy list of recommended documentaries which I try to keep updated as I discover new ones. Check it out and choose one that catches your eye!
    • Monitor your information diet. Our current world is overloaded with information, including a lot that is wrong, misleading, or straight up lies and propaganda. Now more than ever we need to pay close attention to the information we consume on a daily basis. Try to find trustworthy news and educational sites where you can easily verify what they are saying from other sources. Beware of going down esoteric “rabbit holes” where people only confirm their own biases and beliefs. Actively seek out information from multiple sides so you’re at least aware of different perspectives and counter-arguments. The information pyramid is a great guide on how you should prioritize certain sources over others. In general, a peer-reviewed scientific study should be given more weight than some random influencer on social media. Keep in mind it’s also possible to consume too much and become an information junkie, where you’re addicted to learning new things, but you never act on it or put it into practice.
    • Spend time in active reflection. Give yourself time to think and digest, even if it’s just for 10 minutes while sitting with your first cup of coffee in the morning. You don’t always need to be filling your brain with facts to be a smarter person, you also need to know how to step back and contemplate what you know. Active and engaged minds are always taking advantage of opportunities for everyday reflection when sitting on the bus, taking a shower, or walking the dog. Often your best ideas and insights come in moments when you’re not trying to solve a problem directly but just mulling it over in your mind. Schedule time for solitude every now and then and don’t be afraid to sit alone with your thoughts.
    • Learn how your mind works. One essential component to being a more intelligent thinker is knowing how your mind works. We naturally believe we understand ourselves best, but psychology and neuroscience can sometimes reveal counter-intuitive facts and tendencies. To start, our minds are very susceptible to cognitive biases and logical fallacies that can muddy our thinking and understanding of reality. One of the most common errors is black and white thinking, where we believe a situation needs to be either “A” or “B,” but a third perspective, “C,” is the more accurate view. Our minds like to over-simplify things when reality can often be more nuanced and complex. Show intellectual humility. Be open to being wrong and be open to changing your mind in the face of new evidence and experience.

    Take your education seriously. Maintain a healthy and active brain. Even if you were never a good student in school, that doesn’t mean you can’t improve your knowledge and intelligence, especially once you find subjects you are deeply passionate about. Benjamin Franklin once said, “An investment in knowledge pays the best interest.”

    3. EMOTIONAL WELL-BEING

    emotional

    In the “Mental” section we covered how to keep our brains active and be more intelligent thinkers, but there’s also a whole other side of our psychology that we need to pay attention to as well: our “Emotional” side.

    Emotions can often seem like something that we have limited power over, but being a more emotionally intelligent person means becoming more self-aware and learning how to better respond to our emotions in the moment.

    We can’t ignore our emotions or push them aside forever, they are a necessary facet of life and we must learn to navigate our emotional world effectively if we want to live the best life possible.

    Remember that emotions are a resource, not a crutch. Every emotion serves a function or purpose, and if we channel our emotions in a constructive direction we can make great things happen.

    One important lesson is that even negative emotions like sadness, anger, guilt, or fear are helpful to a better life if we approach them from the right perspective.


    Things to do:

    • Learn the basics of emotional intelligence. There are 4 fundamental pillars of emotional intelligence that we need to cultivate: 1) Self-awareness (recognizing our emotions when they happen), 2) Self-regulation (knowing how to respond to our emotions and channel them in a positive direction, 3) Empathy (being aware of other people’s emotions and internal states), and 4) Social Skills (knowing how to respond to other people’s emotions in a healthy and constructive way). Certain people may be strong at some of these and not for others. For example, someone may be really empathetic and caring, but not know how to regulate their own mood and emotions, leading to burnout and emotional fatigue. An emotionally intelligent person must work on all four of these pillars.
    • Improve body awareness. All emotions have a physical component to them. When you learn how to identify the physical sensations behind each emotion, you’ll be much more attuned to your feelings in the moment as you’re experiencing them. This helps you to be more aware of your feelings before acting on them, and to recognize how emotions often want to push or pull you in a certain direction (“do this” vs. “don’t do that”). Every feeling serves a different function depending on its emotional valence (“positive” vs. “negative”) and arousal level (“high energy” vs. “low energy”). With practice, this improved body awareness can also boost your intuition, making you a better reader of your “gut feelings” and what they are telling you.
    • Learn to channel negative emotions. Negative emotions can serve a positive function if you know how to respond to them in a constructive way. If you struggle with any specific negative emotion (sadness, fear, guilt, or anger), then create a plan for how you will respond to it the next time it arises. For example, “If I’m angry, then I’ll go exercise,” or “If I’m sad, then I’ll write in my journal.” Emotions are energy that can be channeled in multiple directions. Write a list of the many ways you can respond to any negative emotion. Remind yourself you have a choice, and you don’t have to keep following the same pattern between negative emotion → negative behavior. One popular technique is opposite action, where you intentionally do the opposite of what a feeling is telling you to do (to reverse the cycle of negativity).
    • Practice meditation and daily mindfulness. Meditation is a great avenue for better understanding and regulating your emotions. It teaches you how to step back and just observe your thoughts and feelings without needing to immediately react to them. This space between “feelings” and “actions” is crucial for being a more emotionally intelligent person; it’s the main principle behind discipline, willpower, and self-control. Never forget that just because you feel a certain way doesn’t mean you need to act on it. If you’re completely new to meditation, start with the 100 breaths meditation – a simple exercise where you just focus on your breathing. It’s also helpful to learn grounding techniques for when you feel overwhelmed, such as mindful stretching or a 5 senses meditation.
    • Embrace creative expression. It’s difficult to describe many emotions with only words so it’s important to embrace other ways of expressing yourself, such as through music, photography, dance, painting, drawing, acting, or film. Often when I meet people who don’t feel fully connected to their emotional self, they usually lack ways of expressing themselves through art and creativity. A creative outlet is often a prerequisite to better understanding and navigating your emotional world, even if you don’t typically think of yourself as a “creative person.”
    • Savor all of your positive experiences. Life is filled with many joys and pleasures throughout the day and we should try to savor them as much as possible. We have many positive emotions to choose from – joy, gratitude, peace, awe, excitement, laughter, and wonder – and there are a variety of activities that can lead to more positive emodiversity in our lives. Don’t just chase after the same positive experiences over and over again, seek new experiences, new hobbies, and new ways of enjoying life. Learn how to savor happiness as much as possible by being more present in the moment, creating positive memories, and reminiscing on good times.
    • Relax and manage daily stress. Last but not least, it’s necessary we cover stress management as an essential component to mental health and emotional intelligence. Stress is a normal part of everyday life, but if you don’t know how to manage it in a healthy way it can often have a negative influence on your thoughts, feelings, and behaviors by making you more sensitive, irritable, angry, and bothered (even by little things that don’t really matter). Recognize when to push yourself vs. when to step back and recharge. In the complete guide on daily stress, you’ll find a great framework for reframing your “fight, flight, or freeze” response by viewing stress as a signal to pay attention to and guide you throughout the day. Don’t underestimate the importance of your comfort zone and use it as a place to recharge after a challenging or overwhelming day.

    Emotions can “make us” or “break us” depending on how emotionally intelligent we are. They are a fundamental part of life, but we often have more power over them than we realize. Learn how to channel your emotions in a healthy and constructive way – become a master of them, not a slave to them.

    4. SOCIAL WELL-BEING

    social

    Healthy and positive relationships are an essential ingredient to happiness and well-being.

    No matter who you are, you crave some type of social connection; even the most introverted person on the planet will have a tough time finding happiness all by themselves.

    There used to be a time when I believed “I don’t need people to be happy, all I need is myself.” But over the years I’ve learned more and more that having social support and a sense of belonging is a basic human need that can’t be avoided.

    How strong is your current social circle? Here’s advice to get you started.


    Things to do:

    • Stay connected with friends and family. You should try your best to stay in touch with people who you already have a strong relationship with, especially family and old friends. There’s a simple power in checking in on people and preserving social connections you’ve already established. It doesn’t take much time or effort to show you’re thinking about someone: a simple text, email, or phone call is all you need to let people know you still care and value your relationship with them. You’d be surprised by how much other people appreciate you reaching out to them, even if you haven’t spoken to them in a really long time.
    • Embrace small social interactions. Every time you leave your home, there is opportunity for social interaction. To build your social muscles, embrace the power of 10 second relationships, such as saying “Hi,” to a neighbor or coworker, small talk with a cashier or cab driver, or sparking up a quick conversation while waiting for the train or bus. Research shows even super tiny social interactions can boost positive emotions and feelings of social connectedness. This can also be a great exercise for people who are very introverted (or have a lot of social anxiety) and want to start being a more social person. Make a plan to have a pleasant interaction with at least one new person every day.
    • Learn how to have endless conversations. One big concern for people when it comes to meeting new people is, “What do I say? What if I run out of things to talk about?” One popular technique known as conversation threading provides an excellent framework so that you never run out of topics to talk about. The basic idea is that every sentence contains multiple “threads” we can go down, and often the art of good conversation is being able to 1) Listen to what people say, and 2) Choose a thread to talk more about. Rinse and repeat and a conversation can go on forever. Also consider improvisation exercises so that you can be a faster and more creative thinker in the moment.
    • Improve communication and conflict resolution. It’s a cliché, but communication is everything in relationships. If you don’t know how to express your thoughts and feelings in an honest and constructive way, you’ll have trouble building genuine and healthy connections with others at home, work, or wherever you need to cooperate and work together with people. In romantic relationships, it’s important to know how to communicate your feelings without manipulating or being dramatic. In family and work environments, it’s important to know how to defuse heated arguments before they spiral out of control. The truth is people can be difficult and you’re not going to like everyone’s company. That’s natural. Conflicts have the potential to arise in any social situation, because people have different beliefs, values, and personalities that may be incompatible with each other. What’s most important is to teach yourself the best methods for conflict resolution so you can better navigate the complexities of your social world.
    • Find opportunities to meet new people. Most people make friends through work or school. Once we get older, it can become more difficult to find new connections or become a part of new social circles. Recent research shows that most adults claim to have “less than 5 close friends.” If you’re looking to expand your circle, there are many opportunities available to you. Depending on your likes, hobbies, and interests, consider going out more to music shows, bars, coffee shops, workshops, church/religious services, bowling leagues, adult education classes, sports events, or book clubs. Seek out local groups in your area or volunteer somewhere. You can also take advantage of websites like Meet Up to connect with like-minded people who live close-by. All it takes is one new friend to introduce you to an entirely new social circle. Be patient and don’t worry if you don’t initially hit it off with the first couple people you meet. Finding the right relationships that fit into our lives can take time.
    • Use social media and the internet to connect. The internet can be a great place to connect with like-minded people who we’d never meet in the real world. Online communities on social media, message boards, or video games can often provide a valuable source of social interaction, especially for people who don’t have many “real life” friends. The internet can be particularly helpful for connecting with others who have rare or eccentric hobbies, such as fans of a specific author, athlete, music genre, or comic book franchise. Unfortunately, many online communities can also become negative, competitive, and toxic (see the online disinhibition effect), so it’s necessary you build a positive digital environment that works for you. That doesn’t mean hiding in your own “echo chamber,” but it does mean cultivating a feed and followers who ultimately add value to your life and don’t subtract it. First focus on topics you’re naturally interested in such as science, technology, sports, or movies. Try not to be a passive consumer of information, actively enter conversations by asking questions or sharing knowledge with others. Often times we can build meaningful connections with people online that are just as important as those we find in the real world. However, while online relationships can have many benefits, we shouldn’t see them as a substitute for real world “face to face” interactions.

    Always remember that quality of relationships > quantity of relationships.

    You don’t need to be super popular or the life of the party to have a healthy social life. All you need is a couple really close friends who support you, trust you, and enjoy your presence. That’s everything you need to be socially satisfied.

    Healthy relationships are a fundamental aspect of happiness and well-being for everyone. Our need to belong to a “tribe” or group is hardwired into our brain, biology, and evolution. Like every other aspect of a balanced person, it can’t be ignored.

    Are your daily social needs being fulfilled?

    5. WORK / FINANCIAL WELL-BEING

    work

    Another fundamental aspect of a balanced person is work, money, and material concerns.

    At the most basic level, we depend on food, clothing, shelter, healthcare, and other necessities so we can live a healthy and dignified life.

    People that struggle to make a living can often hurt in many other areas: physical health (can’t afford good foods, healthcare, or medicine), relationships (can’t support family, no money for dating), as well as our mental and emotional well-being (stress, anxiety, and low self-esteem).

    Unless you win the lottery or have someone else to provide for you, finding a steady job or career is often one of the most focused on areas in life. From childhood up until we finish high school or college, we are constantly asked, “What do you want to do for a living?”

    A few people find jobs they love, many find jobs they like, and most find jobs they can at least tolerate. Balancing psychological needs with financial needs can be a difficult task depending on your current situation.

    While we don’t always get a choice in what we do for a living, there are important ways to give ourselves more power over our work life and financial life. Here are important guidelines to keep in mind.


    Things to do:

    • Focus on your strengths. Everyone has a place in this world where they add value. Before you decide what type of work you’d like to do for a living, it’s important to know what your natural strengths, skills, and talents are. If you’re friendly and good with people, you may excel at managing, customer service, or human resources type jobs. If you’re more introverted and creative, you may want to focus on writing, graphic design, computer programming, or freelance work. What type of activities are you typically good at (or at least above average)? What were your best subjects in school? What do you enjoy doing and why? Complete the strengths worksheet to discover more about your natural skillset. Ultimately, knowing your strengths will influence what types of jobs or career choices will suit you best – including where you contribute the most value.
    • Value education and experience. No matter what your job is, there are always new ways to learn and improve. The best workers in life are those who are always growing and mastering their craft. College is still an important part of education, but what’s even more important is to stay self-motivated and continue learning after school. Many people I know have landed successful jobs that had virtually nothing to do with what they studied in college. In several cases, they were people who taught themselves coding/programming, built a portfolio to show their work to potential employers, and climbed their way up the company ladder from there. All self-taught. You can also consider going to trade schools, workshops, mentorships, internships, and other forms of gaining knowledge and experience that are outside of the traditional college model. Any work experience is better than none at all – you just need to start somewhere and begin building yourself up.
    • Make the most of your job. While it’s rare for any of us to get our “dream job,” we can always make the most of our work life by being a good employee and doing our best. Use nudges to keep yourself motivated and productive throughout the day, learn mental strategies for getting things done that you normally “don’t like” doing, and make friends at work with bosses, coworkers, clients, or customers, because those are the people you’re going to be spending a lot of time with and it’s crucial you have healthy and functioning relationships with them. No matter what your job is try to see the underlying purpose or meaning behind it. What value does it add to the world? Are you proud of the work you do?
    • Live within your means. Regardless of how much money you make, one of the most commonsense rules for financial well-being is living within your means. This includes keeping a budget that you can maintain (for food, rent/mortgage, bills, gas, clothes, and leisure expenses), and not buying too much stuff you can’t immediately afford. Debt can be common at some point in our lives (due to student loans, credit card debt, medical emergencies, etc.), but try to be mindful to not put yourself in a hole that you can’t climb out of. Avoid luxury expenses that put you at financial risk. We sometimes over-extend ourselves due to social comparison and a “keeping up with the Joneses” mentality. We think if our friend or neighbor gets a brand new car or goes on an expensive trip, then we need to “one-up” them with a similar purchase. Many times people fall into massive debt because they are trying to chase status, fame, luxury, or exorbitant pleasures. In general, keep track of all your monthly expenses and find ways to cut back on spending that isn’t necessary. Learn about spending biases that can lead to overconsumption (like the allure of “FREE!,” the “Relativity Trap,” and “One Click” purchases). Big corporations are masters of psychology and persuasion. If we aren’t vigilant about our spending habits (especially if you enjoy retail therapy), then we’ll often fall for tricks that cause us to spend more money than we should.
    • Create a healthy relationship with material things. This article is about being a balanced person. Work and money are very important aspects of life, but materialistic beliefs can also backfire to hurt us. No one lays down on their deathbed wishing they spent more time in the office. Work-a-holics can end up focusing so much on their career that they neglect giving enough attention to their family, health, and well-being. Never forget that there is a lot more to a good life than just money and material things, despite what you may see glamorized in movies, TV shows, or commercials. Psychology research shows that after a certain point, increased wealth and income has very little effect on our overall happiness and life satisfaction. Being rich sounds awesome, but it won’t necessarily make you any happier than if you earned less with a stable and secure life. Take the materialism quiz to see if you have a healthy relationship with money and stuff.

    Remember, money is important but it isn’t everything.

    Financial well-being will often look radically different depending on the person. Certain people may be content with modest and minimal living, while others crave more luxury, adventure, and pleasure. Whichever lifestyle you choose, it’s necessary that money finds the proper role in your life without being completely consumed by it.

    One succinct way to define true financial well-being is “not needing to think about money all the time.”

    6. MEANINGFUL / SPIRITUAL WELL-BEING

    spiritual

    The meaningful or spiritual aspects of life can often be overlooked.

    We may occasionally ask ourselves big questions like, “Who am I?” “Why am I here?” or “What’s my purpose?” but we rarely translate these questions into our daily lives through action.

    For many people, religion is their main source of spirituality and meaning. Attending church, being part of a local community, prayer, and volunteering or giving to charities are common ways people boost meaning in their daily lives. Religion has been shown to improve happiness and well-being by creating a strong sense of purpose and community.

    However, we don’t need religion to have a meaningful life. There are many other sources of meaning, including art, culture, philosophy, literature, music, relationships, activism, introspection, and creativity.

    Where do you get your meaning in life?


    Things to do:

    • Learn the pillars of a meaningful life. One excellent guide on how to live a meaningful life outlines five different pillars to focus on, including 1) A sense of belonging (having healthy relationships with those around you), 2) A sense of purpose (feeling that you contribute to a larger whole), 3) Storytelling (the life story we tell about ourselves, as well as stories and myths about the world we live in), 4) Transcendence (experiencing “awe” and “inspiration” in the presence of great things), 5) Growth (having a sense that you are evolving and moving forward as a person). All five pillars contribute to a rich and meaningful existence.
    • Spend more time in nature. Nature reminds us that we are part of something larger than ourselves, a whole process known as “life.” Nature is a fantastic source of meaning because it continuously inspires positive emotions like joy, amazement, gratitude, and awe. The best part is that nature is all around us – we don’t need to plan a weekend camping trip to experience it – instead just pay attention to everyday nature that is all around you: trees on the drive to work, birdwatching in your backyard, or spending time in your garden over the summer. Having pets to care for is another easy and wonderful source of nature and connection, even if it’s just a small fish tank to maintain. Nature also includes enjoying the beauty of a nice view such as sunrises, sunsets, mountaintops, storm watching, and star-gazing.
    • Take a complete picture perspective. Finding meaning requires being able to look at things from a big picture perspective. What influence do your actions have in the long-term? What type of impact will you leave on the world after you die? When you keep the complete picture in mind, you recognize that even super small actions can add up and have big results in the future. Your life doesn’t begin at birth nor end at death, you are part of an intergenerational chain of cause-and-effect that has stretched thousands of years. That’s a powerful thought if you can see the true significance behind it.
    • Embrace art, music, and culture. Artists are the creators of new meanings, especially famous painters, musicians, filmmakers, photographers, authors, playwrights, and dancers. Pursuing a creative hobby of your own is one fantastic way to infuse new meaning into your life. You can also embrace art and culture more by going to museums, art galleries, music concerts, and theaters. A lot of beautiful art is archived in online art and cultural exhibits, so you can discover a lot of new inspiration by just sitting in the comfort of your own home. Artists of all forms teach us how universal the human condition is. It’s a huge inspirational boost when you realize a book written over a hundred years ago resonates exactly with how you feel today. One of my strongest memories is attending a music concert of my favorite band with thousands of others listening and singing along. Creativity is one of humanity’s greatest gifts and there’s a lot of wisdom, beauty, and feelings of universal connection it can offer us.
    • Signs, symbols, and synchronicity. A meaningful life can be more about feeling inspiration and empowerment rather than thinking only logically and factually about the world. Embrace things you can’t always explain. If you feel like you’re getting a “sign” from the universe, accept it. Our minds often think unconsciously through the power of symbols, especially through reoccurring dreams or nightmares that may be trying to tell you something important. Meaning can be created anywhere if you have the right perspective. Many of my favorite moments in life are when I experience synchronicity, which is finding a connection between two things that seem completely unrelated at first. For example, if I start reading a book and then someone brings up the same book randomly the next day, I try to see that as a sign that I’m on the right path. It may or may not be true, but it is a simple and easy way to add more meaning to the little things in life.
    • Have faith that life is good. Faith may not have any role in science, but it does play an important role in good living. At the end of the day, one of the most important beliefs we can have is that “life is good” and things will generally work out in the end. One of my personal favorite quotes is, “Pray to God, but row to shore.” It shows us to have hope and faith in life, but still take action and try our best in the moment. Both faith and action are necessary ingredients to a happy and fulfilling life. A belief in God or a higher power can make this whole process easier. However, even if you can’t bring yourself to accept “metaphysical” or “supernatural” ideas, at least try to sense the oneness and interconnectedness of all things. These ideas are an endless source of power, strength, and resilience, even in the face of incredible hardships and tribulations.

    A “meaningful life” can be one of the most difficult areas of life to improve, especially while living in a world that is filled with nihilism, hedonism, and materialism.

    However, once you build a strong spiritual core you can withstand almost any difficulty or hardship. It can empower you to a whole new level that non-spiritual people don’t usually have access to.

    CONCLUSION

    To sum things up we must invest time and energy in all six of these aspects if we want to live a happy and balanced life.

    Once again, these six aspects of a balanced life include: 1) Physical, 2) Mental, 3) Emotional, 4) Social, 5) Work/Financial, and 6) Meaningful/Spiritual.

    Which area are you the strongest in? Which area are you the weakest in?

    Keep this framework in mind as you embark on a lifetime of self-improvement. Try the Daily Routine (PDF) exercise and use this resource as a guideline.


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    Steven Handel

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    January 29, 2024
  • ‘If Exercise Could Cure This, I Would Have Been Cured So Quickly’

    ‘If Exercise Could Cure This, I Would Have Been Cured So Quickly’

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    In the weeks after she caught COVID, in May 2022, Lauren Shoemaker couldn’t wait to return to her usual routine of skiing, backpacking, and pregaming her family’s eight-mile hikes with three-mile jogs. All went fine in the first few weeks after her infection. Then, in July, hours after finishing a hike, Shoemaker started to feel off; two days later, she couldn’t make it to the refrigerator without feeling utterly exhausted. Sure it was a fluke, she tried to hike again—and this time, was out of commission for months. Shoemaker, an ecologist at the University of Wyoming, couldn’t do her alpine fieldwork; she struggled to follow a movie with a complex plot. She was baffled. Exercise, the very thing that had reliably energized her before, had suddenly become a trigger for decline.

    For the majority of people, exercise is scientifically, physiologically, psychologically good. It boosts immunity, heart function, cognition, mood, energy, even life span. Doctors routinely prescribe it to patients recovering from chronic obstructive pulmonary disease and heart attacks, managing metabolic disease, or hoping to stave off cognitive decline. Conditions that worsen when people strive for fitness are very rare. Post-exertional malaise (PEM), which affects Shoemaker and most other people with long COVID, just happens to be one of them.

    PEM, first described decades ago as a hallmark of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is now understood to fundamentally alter the body’s ability to generate and use energy. For people with PEM, just about any form of physical, mental, or emotional exertion—in some cases, activities no more intense than answering emails, folding laundry, or digesting a particularly rare steak—can spark a debilitating wave of symptoms called a crash that may take weeks or months to abate. Simply sitting upright for too long can leave Letícia Soares, a long-hauler living in Brazil, temporarily bedbound. When she recently moved into a new home, she told me, she didn’t bother buying a dining table or chairs—“it just felt useless.”

    Read: How much less to worry about long COVID now

    When it comes to PEM, intense exercise—designed to boost fitness—is “absolutely contraindicated,” David Putrino, a physical therapist who runs a long-COVID clinic at Mount Sinai, in New York, told me. And yet, the idea that exertion could undo a person rather than returning them to health is so counterintuitive that some clinicians and researchers still endorse its potential benefits for those with PEM; it’s dogma that Shoemaker heard repeatedly after she first fell ill. “If exercise could cure this,” she told me, “I would have been cured so quickly.”

    The problem is, there’s no consensus about what people who have PEM should do instead. Backing off physical activity too much might start its own downward spiral, as people lose muscle mass and strength in a phenomenon called deconditioning. Navigating the middle ground between deconditioning and crashing is “where the struggle begins,” Denyse Lutchmansingh, a pulmonary specialist at Yale, told me. And as health experts debate which side to err on, millions of long-haulers are trying to strike their own balance.


    Though it’s now widely accepted that PEM rejiggers the body’s capacity for strain, scientists still aren’t sure of the precise biological causes. Some studies have found evidence of impaired blood flow, stymieing the delivery of oxygen to cells; others have discovered broken mitochondria struggling to process raw fuel into power. A few have seen hints of excessive inflammation, and immune cells aberrantly attacking muscles; others point to issues with recovery, perhaps via a slowdown in the clearance of lactate and other metabolic debris.

    The nature of the crashes that follow exertion can be varied, sprawling, and strange. They might appear hours or days after a catalyst. They can involve flu-like coughs or sore throats. They may crater a patient’s cognitive capacity or plague them with insomnia for weeks; they can leave people feeling so fatigued and pained, they’re almost unable to move. Some of Shoemaker’s toughest crashes have saddled her with tinnitus, numbness, and extreme sensitivity to sound and light. Triggers can also change over time; so can people’s symptoms—even the length of the delay before a crash.

    But perhaps the worst part is what an accumulation of crashes can do. Rob Wüst, who studies skeletal-muscle physiology at Amsterdam University Medical Center, told me that his team has found an unusual amount of muscle damage after exertion in people with PEM that may take months to heal. People who keep pushing themselves past their limit could watch their baseline for exertion drop, and then drop again. “Every time you PEM yourself, you travel a little further down the rabbit hole,” Betsy Keller, an exercise physiologist at Ithaca College, told me.

    Read: Long COVID has forced a reckoning for one of medicine’s most neglected diseases

    Still, the goal of managing PEM has never been to “just lay in a bed all day and don’t do anything,” Lily Chu, the vice president of the International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME), told me. In the 1960s, a group of scientists found that three weeks of bed rest slashed healthy young men’s capacity for exertion by nearly 30 percent. (The participants eventually trained themselves back to baseline.) Long periods of bed rest were once commonly prescribed for recovery from heart attacks, says Prashant Rao, a sports cardiologist at Beth Israel Deaconess Medical Center, in Massachusetts. But now too much rest is actively avoided, because “there’s a real risk of spiraling down, and symptoms worsening,” Rao told me. “I really fear for that, even for people with PEM.”

    There is no rulebook for threading this needle, which has led researchers to approach treatments and rehabilitation for long COVID in different ways. Some clinical trials that involve exercise as an intervention explicitly exclude people with PEM. “We did not feel like the exercise program we designed would be safe for those individuals,” Johanna Sick, a physiologist at the University of Vienna who is helping run one such trial, told me.

    Other researchers hold out hope that activity-based interventions may still help long-haulers, and are keeping patients with PEM in experiments. But some of those decisions have been controversial. The government-sponsored RECOVER trial was heavily criticized last year for its plan to enroll long-haulers in an exercise study. Scientists have since revised the trial’s design to reroute participants with moderate to severe PEM to another intervention, according to Adrian Hernandez, the Duke cardiologist leading the trial. The details are still being finalized, but the plan is to instead look at pacing, a strategy for monitoring activity levels to ensure that people stay below their crash threshold, Janna Friedly, a physiatrist at the University of Washington who’s involved in the trial, told me.

    Certain experimental regimens can be light enough—stretching, recumbent exercises—to be tolerable by many (though not all) people with PEM. Some researchers are trying to monitor participants’ heart rate, and having them perform only activities that keep them in a low-intensity zone. But even when patients’ limitations are taken into account, crashes can be hard to avoid, Tania Janaudis-Ferreira, a physiotherapist at McGill University, in Quebec, told me. She recently wrapped a clinical trial in which, despite tailoring the regimen to each individual, her team still documented several mild to moderate crashes among participants with PEM.

    Read: Long COVID is being erased—again

    Just how worrisome crashes are is another matter of contention. Pavlos Bobos, a musculoskeletal-health researcher at the University of Western Ontario, told me that he’d like to see more evidence of harm before ruling out exercise for long COVID and PEM. Bruno Gualano, a physiologist at the University of São Paulo, told me that even though crashes seem temporarily damaging, he’s not convinced that exercise worsens PEM in the long term. But Putrino, of Mount Sinai, is adamant that crashes set people back; most other experts I spoke with agreed. And several researchers told me that, because PEM seems to upend basic physiology, reduced activity may not be as worrisome for people with the condition as it is for those without.

    For Shoemaker, the calculus is clear. “Coming back from being deconditioned is honestly trivial compared to recovering from PEM,” she told me. She’s willing to wait for evidence-based therapies that can safely improve her PEM. “Whatever we figure out, if I could get healthy,” she told me, “then I can get back in shape.”


    At this point, several patients and researchers told me, most exercise-based trials for long COVID seem to be at best a waste of resources, and at worst a recipe for further harm. PEM is not new, nor are the interventions being tested. Decades of research on ME/CFS have already shown that traditional exercise therapy harms more often than it helps. (Some researchers insisted that more PEM studies are needed in long-haulers—just in case the condition diverges substantially from its manifestation in ME/CFS.) And although a subset of long-haulers could be helped by exercise, experts don’t yet have a great way to safely distinguish them from the rest.

    Even pacing, although often recommended for symptom management, is not generally considered to be a reliable treatment, which is where most long-COVID patient advocates say funds should be focused. Ideally, Putrino and others told me, resources should be diverted to trials investigating drugs that might address PEM’s roots, such as the antiviral Paxlovid, which could clear lingering virus from long-haulers’ tissues. Some researchers are also hopeful about pyridostigmine, a medication that might enhance the delivery of oxygen to tissues, as well as certain supplements that might support mitochondria on the fritz.

    Those interventions are still experimental—and Putrino said that no single one is likely to work for everyone. That only adds to the challenge of studying PEM, which has been shrouded in disbelief for decades. Despite years of research on ME/CFS, Chu, of the IACFS/ME, told me that many people with the condition have encountered medical professionals who suggest that they’re just anxious, even lazy. It doesn’t help that there’s not yet a blood test for PEM; to diagnose it, doctors must ask their patients questions and trust the answers. Just two decades ago, researchers and physicians speculated that PEM stemmed from an irrational fear of activity; some routinely prescribed therapy, antidepressants, and just pushing through, Chu said. One highly publicized 2011 study, since widely criticized as shoddy science, appeared to support those claims—influencing treatment recommendations from top health authorities such as the CDC.

    The CDC and other organizations have since reversed their position on exercise and cognitive behavioral therapy as PEM treatments. Even so, many people with long COVID and ME/CFS are still routinely told to blow past their limits. All of the long-haulers I spoke with have encountered this advice, and learned to ignore it. Fighting those calls to exercise can be exhausting in its own right. As Ed Yong wrote in The Atlantic last year, American society has long stigmatized people who don’t push their way through adversity—even if that adversity is a medically documented condition that cannot be pushed through. Reconceptualizing the role of exercise in daily living is already a challenge; it is made all the more difficult when being productive—even overworked—is prized above all else.

    Read: Fatigue can shatter a person

    Long-haulers know that tension intimately; some have had to battle it within themselves. When Julia Moore Vogel, a researcher at Scripps, developed long COVID in the summer of 2020, she was at first determined to grit her way through. She took up pilates and strength training, workouts she at the time considered gentle. But the results were always the same: horrific migraines that relegated her to bed. She now does physical therapy to keep herself moving in safe and supervised amounts. When Vogel, a former competitive runner, started her program, she was taken aback by how little she was asked to do—sometimes just two reps of chin tucks. “I would always laugh because I would be like, ‘These are not exercises,’” she told me. “I’ve had to change my whole mental model about what exercise is, what exertion is.”

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    Katherine J. Wu

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    January 25, 2024
  • Hearing Loss: The Mental and Emotional Impact

    Hearing Loss: The Mental and Emotional Impact

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    The Mental and Emotional Impact of Hearing Loss

































    091e9c5e820faac4091e9c5e820faac4FED-Footermodule_FED-Footer_091e9c5e820faac4.xmlwbmd_pb_templatemodule0144002/02/2021 01:57:340HTML















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    December 14, 2023
  • Insomnia, Sleep Apnea Rise in Women With MS

    Insomnia, Sleep Apnea Rise in Women With MS

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    By Cara Murez 

    HealthDay Reporter

    MONDAY, March 27, 2023 (HealthDay News) — While thinking declines can be a common symptom of multiple sclerosis in women, new research suggests sleep, or lack of it, could be making matters worse.

    “Sleep disorders have gained substantial recognition for their role in cognitive [thinking] decline, which affects up to 70% of people with multiple sclerosis,” explained study author Dr. Tiffany Braley, director of the Multiple Sclerosis/Neuroimmunology Division and the MS Fatigue and Sleep Clinic at University of Michigan Health.

    “Our results highlighted important pathways between sleep and perceptions of cognitive function in women with MS,” Braley said in a university news release. “We have previously identified important associations between objective cognitive performance and sleep in people with MS, but little is known about how sleep and MS interact together to impact long-term cognitive outcomes, particularly among women who are less likely to be diagnosed with sleep disorders.”

    Using data for more than 60,000 women in the 2013 and 2017 waves of the Nurses’ Health Study, the reseachers found that women with MS were more likely than those without MS to report sleep disorders such as obstructive sleep apnea, insomnia and sleepiness.
     

    Sleep disorders identified in 2013 contributed to thinking problems reported by women with MS in 2017, including memory and ability to follow instructions and conversations, according to the authors.

    Sleep apnea accounted for 34% of the total effect between MS and the ability to follow instructions, the study found.

    The findings were published recently in the Multiple Sclerosis Journal.

    “With this longitudinal study design, we are able to better estimate the burden of sleep disorders among nurses, compared to health care claims data of similar size, which include diagnosed people with sleep disorders,” said senior study author Galit Levi Dunietz, an associate professor in the Department of Neurology’s Division of Sleep Medicine at Michigan Medicine.

    “However, as sleep disorders are frequently underdiagnosed, health care claims data miss many people with sleep disorders who were not evaluated for these conditions,” Dunietz said in the release.

    Interventions to delay thinking issues may be most effective in pre-symptomatic or early symptomatic stages, Braley noted.

    “Perceived cognitive decline, even in the absences of objective changes, could be an important window of opportunity to identify treatable exacerbating factors, such as sleep disorders,” she said.

    More information

    The National Multiple Sclerosis Society has more on thinking declines in people with MS.

     

    SOURCE: Michigan Medicine – University of Michigan, news release, March 21, 2023

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    March 27, 2023
  • Diabetes, Tooth Loss Can Be Double Trouble for Aging Brains

    Diabetes, Tooth Loss Can Be Double Trouble for Aging Brains

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    By Cara Murez 

    HealthDay Reporter

    WEDNESDAY, March 15, 2023 (HealthDay News) — Diabetes is a known risk factor for mental decline and dementia. Paired with total tooth loss, the potential harm to the brain is even more significant, new research indicates.

    The findings highlight the importance of good dental care and diabetes control in aging adults, said Bei Wu, lead author of a new study of nearly 10,000 adults.

    “Access to dental care for older adults, especially those with diabetes, is really important,” said Wu, vice dean for research at the New York University Rory Meyers College of Nursing and co-director of the NYU Aging Incubator in New York City.

    The American Diabetes Association recommends regular dental checkups for anyone with diabetes — “but how many people are following that and how many clinicians are recommending this?” Wu said.

    On its own, poor oral health, especially gum disease and tooth loss, has also been linked to cognitive impairment and dementia.

    Wu notes that researchers are now beginning to understand how oral health, diabetes and cognitive decline may exacerbate one another. 

    “We need to raise awareness of this,” she said.

    Inflammation plays a role in both diabetes and gum disease, the study notes. These inflammatory processes may contribute to declines in reasoning and thinking skills — so-called cognitive decline. 

    Poor nutrition is another pathway. Having painful gums and missing teeth can make it difficult to chew healthy food. This can lead to nutritional deficiency. The impaired blood sugar levels and insulin sensitivity found in diabetes can also worsen nutritional deficiency, according to the study.

    And certain bacteria related to chronic periodontitis, or gum disease, may also affect cognitive function, Wu said.

    To study this in combination, the researchers divided older adults into groupings by age: 65 to 74, 75 to 84 and 85 and older.

    The researchers used data from the University of Michigan’s Health and Retirement Study for 2006 to 2018, which measured memory and cognition every two years. This included 9,948 older adults. 
     

    In adults ages 65 to 84, those with diabetes and complete tooth loss together had the highest rate of accelerated mental decline compared to those with neither condition.

    Those with just diabetes ages 65 to 74 or just complete tooth loss ages 65 to 84 also had faster cognitive decline.

    But mental decline was fastest in those ages 65 to 74 with both diabetes and total tooth loss.

    Researchers did not find conclusive evidence linking mental decline with toothlessness and diabetes in adults ages 85 and older.

    They theorized that perhaps the less healthy among this group had already died before their reaching their late 80s. Or it’s possible that this age group already had greater cognitive impairment.

    Wu noted that the study is observational and can’t prove cause and effect.

    Cautioning that he is not a diabetes expert, Dr. Cyprien Rivier, a postdoctoral fellow in neurology at Yale School of Medicine, said the connections between diabetes and periodontitis make sense. Rivier was not involved in the study.
     

    Experts are aware that inflammation leads to changes in the microarchitecture of the brain.

    “We know that when there are high levels of systemic inflammations, the white matter is getting a bit more disorganized,” Rivier said.
     

    This leads to worse brain health and cognitive outcomes, he said.

    Mouth health is very important for other areas of the body, including heart health, Rivier noted. For example, the American Heart Association says patients who’ve had heart valve issues must take antibiotics before certain dental procedures because of bacteria that can travel through the bloodstream.
     

    “The effects of oral health on the whole body are now really well-defined,” Rivier said.
     

    More studies are needed to assess these connections, yet good dental health is an easy and important target for improving health, Rivier said.

    “It’s rather inexpensive. It’s pretty easy to improve oral health on a population level,” Rivier said.

    The study authors say older adults who have poor dental health and diabetes would benefit from cognitive screenings from their primary care providers.

    The study findings were published March 12 in the Journal of Dental Research.

    More information

    The U.S. National Institute on Aging has more on cognitive health and older adults.

     

    SOURCES: Bei Wu, PhD, vice dean for research, New York University Rory Meyers College of Nursing and co-director, NYU Aging Incubator, New York City; Cyprien Rivier, MD, MSc, postdoctoral fellow, neurology, Yale School of Medicine, New Haven, Conn.; Journal of Dental Research, March 12, 2023

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    March 15, 2023
  • Groundbreaking Changes for Continuing Care Retirement Community Kendal at Lexington

    Groundbreaking Changes for Continuing Care Retirement Community Kendal at Lexington

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    The Kendal Corporation begins a $40M construction project to better serve Lexington community.

    Press Release
    –


    updated: Feb 20, 2018


    LEXINGTON, Virginia, February 20, 2018 (Newswire.com)
    –
    ​​In the picturesque Shenandoah Valley, a vibrant community of nearly 200 independent senior residents, medical and continuing care providers, and their Lexington, Virginia neighbors gathered Thursday for a highly celebrated groundbreaking ceremony that kicked off a $40M renovation and expansion initiative.

    The project was designed to make life brighter and more homelike for residents, to make facilities friendlier to those who suffer from cognitive decline and to provide a model work environment for Kendal’s highly skilled staff. When it is complete, the Borden Health Center will be the most up-to-date skilled care nursing facility in the region and will continue to provide care to residents and regional neighbors alike. Currently, 80 percent of Borden admissions come from the general community, 40 percent of those are supported by Medicaid.

    We are proud of our long legacy of partnering with, and caring for, both our full-time community residents and our Lexington area neighbors. After the renovations, the residents and staff living and working in the skilled care and assisted living centers will enjoy bright, home-like settings with modern amenities and comforts, and we really want to get the word out that our facility is open to everyone.

    Bob Glidden, Kendal at Lexington Board of Directors Chairman

    “We are proud of our long legacy of partnering with, and caring for, both our full-time community residents and our Lexington area neighbors,” Board Chair Bob Glidden said. “After the renovations, the residents and staff living and working in the skilled care and assisted living centers will enjoy bright, home-like settings with modern amenities and comforts and, our facilities are open to everyone.”

    Additionally, the Webster Assisted Living Center and the Anderson Dining room will both be upgraded to increase Kendal’s legendary neighborhood community feel. The architects have reworked the existing footprint to enhance natural light and remove structural obstacles.

    “In each planned renovation, we carefully considered the needs of our residents and seek to meet and exceed model care practices, even as expectations and opportunities for advancement continue to evolve. We work every day to ensure that Kendal at Lexington is the kind of place we would all choose as our home,” Mina Tepper, Executive Director at Kendal at Lexington said.

    In addition to the care facility upgrades, the phase three Kendal expansion will produce 30 new independent living cottages, increasing the number of residential living opportunities by 25 percent.

    “To see Kendal expand to meet our original vision is truly remarkable,” Dianne Herrick, one of Kendal at Lexington’s original founders and a current full-time resident, said. “There is so much we now know about what it takes to provide a positive aging experience, and Kendal is at the cutting edge, delivering fulfilling experiences to all its residents. I’m just so excited for what comes next.”

    More information: http://kalex.kendal.org/expansion/press

    Media Contact:

    Jennifer Eddy
    202-709-7509 (w) | 540-878-9681 (c)
    j.eddy@eddycommunications.com

    Source: Kendal at Lexington

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    February 20, 2018

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