SASKATOON, Saskatchewan–(BUSINESS WIRE)– #HealthcareInnovations–ZYUS Life Sciences Corporation (the “Company”) (TSX-V: ZYUS), a Canadian-based life sciences company leading scientific research and global development of innovative cannabinoid-based pharmaceutical drug products, today announced the appointment of Hance Clarke, MD, PhD, FRCPC to ZYUS Life Sciences Inc.’s Clinical Advisory Committee. Dr. Clarke’s extensive background in healthcare and pain management aligns seamlessly with the committee’s mission to pro
Peter Smith, owner of Starlight Cinema Taupō for 43 years (centre) with new owners Tammy and Charlie Prince.
Taupō’s only movie theatre is shutting at the end of the month and the operators have yet to secure a viable alternative venue.
Starlight Cinema’s closure has as much to do with a series of unfortunate events and bad timing as financial viability.
The building which houses the theatre and five retail shops, comes up well short of modern earthquake standards and is set to be demolished, as early as next month.
Previous cinema owner Peter Smith had plans for a brand new purpose-built theatre building in Taupō, but then Covid-19 struck and put a halt to proceedings.
In the meantime, with plans for a new theatre in place, landlord Glynn Pointon purchased the building to knock it down and replace it with three shops at ground level and six subterranean shops accessible from a fully enclosed Starlight Arcade.
In May 2022, with plans for a new theatre building shelved, Smith – who had run the cinema for 43 years – sold it to local couple Tammy and Charlie Prince. Charlie said they were fully aware at the time that the lease on the building would be short-lived.
“So it was coming down either way. We were only guaranteed 12 months in here so we got lucky and got an extra nine months. I didn’t pay a lot for the business. I basically bought the equipment and the stock.”
The building that houses Starlight Cinema in Taupō is old, not up to…
(Bloomberg) — After relaxing its rules on CBD products for both its players and teams, the Brooklyn Nets and New York Liberty have become the first NBA & WNBA team to strike a deal in the CBD category.
The teams, which are under the parent company BSE Global, have signed a multiyear deal with Mynd Drinks, a CBD plant based drink that is THC free. The deal will make Mynd the official wellness and recovery drink partner for both clubs. Official terms of the deal were not disclosed. Mynd also has a deal with the Chicago Cubs, with Major League Baseball agreeing CBD sponsorships in 2022.
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The NBA has been shifting its stance on hemp-based products, and began permitting its teams to sell partnerships in the CBD category in the 2023 off season.
Similarly, the league and its players association agreed to officially removed marijuana from its anti-drug testing program. The collective bargaining agreement between the two organization’s allows players to invest or own passive, non-controlling stakes in CBD companies that also produce marijuana and fully invest in companies that specifically produce CBD. The league and its union’s examples of products containing CBD are oils, creams, drinks, pills and powders.
It however does not allow players to promote marijuana. If a player wishes to promote a CBD product that is produced by a marijuana company, they would need to first get permission from the NBA and…
Harms of high THC content can be avoided through education
The Jan. 25 editorial “High-potency marijuana carries health risks” misses several important realities about cannabis users. I agree with most of the harms stated in the article, many of which can be avoided by educating consumers to “start low, go slow,” and by scrupulously avoiding cannabis use in vulnerable populations, such as teens, pregnant or breastfeeding women, and people with a history of psychosis.
As a cannabis clinician and participant in the legalization movement for the last quarter century, I have found that, in my experience, most cannabis users regulate their consumption, or self-titrate, to their own level of comfort. Your editorial makes it sound as if cannabis users typically use more and more of the product, but cases of marijuana use disorder are rare. It is uncomfortable to consume too much. This is where the anxiety and paranoia come in, and cannabis users tend to try to avoid this.
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I agree that we fetishize high THC levels and that both the cannabis experience and the health of cannabis users might be better with lower THC consumption. We should incorporate the other components of cannabis more, such as CBD and other minor cannabinoids, not just THC. Yet if we limit the potency, people are likely to consume larger amounts to reach the same desired effect. All this accomplishes is to make the…
AUSTIN, Texas & ROTTERDAM, Netherlands–(BUSINESS WIRE)–LED lighting leaders Fluence and Dutch researchers Innexo partner to explore eliminating cannabis vegetation phase, drive energy savings for growers. Source link … Read More
STAMFORD – True to its function, the Planning Board this week signaled likely revisions to the city’s landscape.
Board members approved a zoning change that will allow redevelopment of a busy corner in the heart of downtown, and they cleared the way for two more marijuana dispensaries that would bring the city to its limit of five.
The Planning Board considers applications and votes to recommend whether the Zoning Board should approve them.
So the Planning Board sets the table.
The first request involved the 120,000-square-foot freestanding building at Broad and Summer streets that has been a retail anchor since the 1960s. For decades it was a Caldor discount department store, a downtown landmark. Now it’s a Burlington clothing store.
The plan for the site is unclear. Land-use consultant Rick Redniss went before the Planning Board seeking conformity for what he called a “split zone” – regulations now allow building heights of 150 feet in one section of the property and 75 feet in the other.
Redniss requested a zone change to permit 85-foot buildings in the second section. It complies with the recently updated building code, Redniss said, and the property-wide 85-foot height “is important to how this whole site lays out.”
Redniss offered no details about what is planned for the corner, but Planning Board Chair Theresa Dell asked him about a possible apartment building.
SAN FRANCISCO–(BUSINESS WIRE)–Nabis, the leading licensed cannabis wholesale platform in the world’s largest legal market, announces the launch of Nabis Capital. The resource is an updated and streamlined payment solution that supports brand partners by helping to simplify cash flow and provide a form of working capital that is otherwise unavailable to licensed operators. “There’s undoubtedly a large gap in the cannabis fintech space, and Nabis is proud of the work we’ve done to build out thi
NEW YORK–(BUSINESS WIRE)–The Cannabist Company Holdings Inc. (NEO: CBST) (OTCQX: CBSTF) (FSE: 3LP) (“The Cannabist Company” or the “Company”), one of the largest and most experienced cultivators, manufacturers and retailers of cannabis products in the U.S., announced today it has enhanced its national brand platform through the addition of the Ciencia Labs portfolio of award-winning, science-based brands and products, including Dreamt, Luchador and Quell. Ciencia Labs was founded and led by t
What does cannabis, coca leaf, and all coffee have in common? They all contain alkaloids, a powerful group of medicinal compounds found in plants around the world. While little is presently known about cannabis alkaloids, they are suspected to possess impressive medical benefits like other plant alkaloids.
Alkaloids vs. Cannabinoids
Alkaloids are “one of the most common groups of chemicals that [have] medicinal properties found in plants,” commonly used alkaloids include “morphine, cocaine, nicotine, caffeine, quinine, ephedrine, and many more.” They derive their name, alkaloid, from the word alkali, chemicals that react like bases, counteracting acids. Usually found in the outer tissues of plants, the bitter flavor of alkaloids is believed to be a natural defense in plants to prevent them being eaten by herbivores, similar to cannabinoids and terpenes which both assist in preventing predation.
While cannabinoids like THC, CBD, CBG, and THCv, are oily, lipohpilic (binds to fats), and hydrophobic (do not bind to water) compounds, alkaloids are a very different class of chemicals. The biggest chemical difference between alkaloids and cannabinoids is that all alkaloids include a nitrogen atom which binds to additional hydrogen atoms. Cannabinoids, on the other hand, do not have any nitrogen atoms and contain a chain of carbon atoms, which gives them their oily character.
Courtesy Duke University
Despite their differences, efficient methods to extract both alkaloids and cannabinoids from plants is to simply burn the leaves or other parts that contain the chemicals, or perform a chemical extraction. These methods have been used for thousands of years for both types of chemicals; the caffeine in coffee is chemically extracted by brewing with water, cannabis is smoked, and cocaine was originally extracted through chewing or brewed as a tea.
Discovery of Alkaloids in Cannabis
Cannabis is a verycomplicated plant and “more than 500 compounds have been reported from C. sativa, of which 125 cannabinoids have been isolated and/or identified as cannabinoids.” Non-cannabinoid constituents of cannabis include “42 phenolics, 34 flavonoids, 120 terpenes and 2 alkaloids.” Though, there is some debate over the number of alkaloids which have been identified.
The discovery of alkaloids in cannabis actually manages to predate the discovery of the first cannabinoid, CBN, back in 1896, by more than a decade. In 1881, the first research on the alkaloid cannabinine was presented at the British Pharmaceutical Conference, and two years later another physiologically active alkaloid, tetanocannabin, was discovered. Cannabis alkaloid research then remained dormant until the 1970s.
In 1971, a group of scientists isolated four different alkaloids from cannabis, which they named cannabimines A-D. In 1975, two teams of researchers at the University of Mississippi (UMiss) identified and isolated the first spermidine alkaloid, cannabisativine, from the roots, leaves, and stems of both Mexican and Thai cultivars. The next year, the same researchers at UMiss isolated the second spermidine alkaloid, anhydrocannabisativine and showed that cannabisativine could be converted to anhydrocannabisativine.
While the cannabis alkaloids cannabisativine and annhydrocannabisativine were first discovered in Mexican and Thai cultivars, anhydrocannabisativine has since been “found in plant samples of Cannabis from 15 different geographical locations.”
Which Part of The Plant Has the Most Alkaloids?
Just like how not every part of a cannabis plant has the same amount of cannabinoids, alkaloids are also unequally distributed around the plant. Research has repeatedlyshown that, “cannabis roots are not a significant source of cannabinoids or the aforementioned terpenes, but are rich in other compounds, including … alkaloids.” So while terpenes and cannabinoids are concentrated primarily in the trichomes on the leaves, cannabis alkaloids are primarily found in the roots (but can be found in the stems and leaves as well).
Medical Effects of Cannabis Alkaloids
While cannabis alkaloids have a lot of medical potential, the specifics of that potential are unknown. In the case of cannabisativine and anhydrocannabisativine, “no pharmacological information is available,” but it is believed that “there are several compounds in cannabis root with potential anti-inflammatory activity, including alkaloids.”
Other researchers have noted that, as a class of compounds, “alkaloids may be used as analgesics, antibiotics, anticancer drugs, antiarrhythmics, asthma medications, antimalarials, anticholinergics, bronchodilators, laxatives, miotics, oxytocics, vasodilators, psychotropics, and stimulants,” and that likely includes cannabis alkaloids. One study of cannabis alkaloids found them to “have diuretic, analgesic, anticancer, antipyretic, and antiemetic effects.”
In one study, a petroleum ether solution of cannabis alkaloids and cannabinoids had “a course of action comparable to that of atropine,” a drug commonly given to reduce fluid in the respiratory tract during surgery, which “can also treat insecticide or mushroom poisoning.” It is not clear to what extent those observed effects were due to the alkaloids or the cannabinoids.
A Quick Hit
Despite being one of the most common groups of medicinal chemicals found in plants, alkaloids are some of the least known chemicals in cannabis. Early research shows that they may have strong medical benefits as part of the entourage of medicinal compounds in cannabis.
LOUISVILLE, Ky.–(BUSINESS WIRE)–Brown-Forman Corporation (NYSE:BFA,BFB) announced today a change in its European leadership and Executive Leadership Team (ELT). Effective March 1, 2024, Yiannis Pafilis will become Executive Vice President, President, Europe, and join the ELT. Marshall Farrer, who currently serves as Executive Vice President, Chief Strategic Growth Officer and President, Europe, will retain his responsibilities as Chief Strategic Growth Officer and continue to serve on the ELT
Lexaria Bioscience Corporation, a global innovator in drug delivery platforms, announced that on January 29 it has submitted its much-anticipated Investigational New Drug (IND) application with the US Food and Drug Administration (FDA) for its planned US phase 1b hypertension clinical trial HYPER-H23-1 of DehydraTECH-CBD.
This IND submission follows a successful pre-IND meeting with the US FDA which provided Lexaria with guidance related to the development and filing of the IND. From 2018 through 2023, Lexaria sponsored five investigator-initiated human clinical studies of its DehydraTECH-CBD in an aggregate total of 134 people, without recording a single serious adverse event (the “Studies”). These Studies evidenced significant reductions in resting blood pressure over both acute and multi-week dosing regimens alone and, in some cases, complementary to standard of care medications; suggesting that DehydraTECH-CBD has the potential to have broad therapeutic utility.
As indicated at the FDA website, “once the IND is submitted, the sponsor must wait 30 calendar days before initiating any clinical trials. During this time, FDA has an opportunity to review the IND for safety to assure that research subjects will not be subjected to unreasonable risk.”
Lexaria looks forward to commencing clinical trial HYPER-H23-1 as soon as possible following IND effectiveness, subject to certain conditions including funding. The…
Federal agents thwarted the plans of two travelers attempting to embark on a cruise from PortMiami with illegal cargo.
The travelers, identified as Michael Quesenberry and Savannah Rose Minami are facing several charges.
According to the arrest report, agents seized more than 150 pounds of marijuana from the pair.
The illegal cargo discovery
Department of Homeland Security reported that 112 vacuum-sealed bags of marijuana were found in their luggage.
Reports are that Quesenberry and Minami boarded the Norwegian Joy on January 11 to Southampton, England.
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The inspection
According to reports, agents inspected Quesenberry’s luggage and found 56 separate vacuum-sealed bags, containing a green, leafy substance.
It was later tested positive for marijuana.
After that discovery, agents searched Minami’s luggage and found 56 more bags, packed with marijuana.
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Charges
Quesenberry and Minami face several charges, including conspiracy to export/intent to distribute a controlled substance, attempted exportation of a controlled substance, and possession with intent to distribute a controlled substance.
A Houston-area couple feels victimized all over again after their recent trip to New Orleans. Minnie Washington checked her mail Tuesday and says she found a $135 ticket from the City of New Orleans. Washington said it happened after her and her husband’s truck was stolen right outside their hotel. Making the situation even worse, two days after that, the Washingtons say they were horrified to spot the Chevy Silverado used in a double shooting in the CBD.
NEW ORLEANS —
A Houston-area couple feels victimized all over again after their recent trip to New Orleans.
Minnie Washington checked her mail Tuesday and says she found a $135 ticket from the City of New Orleans.
Washington said it happened after her and her husband’s truck was stolen right outside their hotel.
Making the situation even worse, two days after that, the Washingtons say they were horrified to spot the Chevy Silverado used in a double shooting in the CBD.
The total loans portfolio registered a significant 11.6 per cent increase from December 31, 2022, reaching Dh88.9 billion.
The bank has reported that a notable increase in net profit was attributed to exceptional revenue contributions from both net interest and other operating income bolstered by substantial loan growth. Higher market interest rates also influenced the uptick in revenue.
The positive outlook for UAE business activity and confidence is also sustained by robust domestic non-oil business activity.
Commenting on the bank’s performance, Dr Bernd van Linder, Chief Executive Officer, said, “CBD has accomplished an outstanding result attributable to excellent revenue growth and improved broad-based business performance.”
The Department of Justice has rescinded a DEA decision to fire a special agent who was let go due to a positive reading for CBD on a drug test.
DEA special agent Anthony L. Armour will be re-hired as a special agent and be reimbursed for back pay and legal expenses after a years-long court battle that stretches back to 2019 when a routine drug test showed he had been using CBD, which Armour maintained in court was for the purpose of treating chronic pain in lieu of highly-addictive opioid based painkillers.
“I’m excited to be getting back to work at DEA,” Armour said to The New York Times. “I hope to finish my career at DEA by helping its mission in taking dangerous drugs like fentanyl off the streets.”
Armour’s battle with chronic pain goes back to an injury he sustained during his college football career. He was also injured on the job as a DEA agent in a car crash during a surveillance operation, after which he suffered from back pain and a sprained neck. He ordered CBD products and a vaporizer from the internet, under the impression that he was not taking any illegal risks as the 2018 Farm Bill federally legalized hemp products.
“For Armour and many others in this country, this change meant new opportunities—particularly as to CBD, a non-THC cannabinoid in the cannabis plant,” a portion of the lawsuit said. “Armour hoped CBD oils could play a role in his pain management. That he did is unsurprising. From Martha Stewart to Wrigley Field, CBD has become embedded in American culture.”
After he failed the drug test, Agent Armour turned the CBD products he had ordered into his superiors. Under federal law, hemp-derived products are defined as such if they contain less than 0.3% THC (please follow these handy-dandy little hyperlinks if you want more information on the clusterfuck of loopholes the Farm Bill created with regard to hemp-derived cannabis products). Of the three different hemp-based products Agent Armour turned in, court documents showed that two of them tested within the 0.3% THC range but one of them tested above the allowed threshold at 0.35%, which could be due to the notoriously unreliable potencies of hemp products and the methods by which they are tested.
The DEA even went so far as to double down on their decision years into the lawsuit in late August of 2023. They filed a court brief defending Agent Armour’s termination just days before the Department of Health and Human Services officially recommended the federal rescheduling of cannabis from Schedule 1 to Schedule 3. The DEA also issued an official notice to all DEA employees after Armour’s termination to avoid all CBD products despite their federally legal status.
“Mr. Armour was an outstanding DEA agent when he took a chance in 2019. He believed it was unlikely that CBD products would cause him to test positive for marijuana, but he knew it was possible, and he bought those unregulated products on the internet and consumed them anyway,” the DEA brief said. “Mr. Armour argues that he ‘displayed negligence or poor decision-making,’ and DEA properly held him accountable for his poor decisions when they resulted in a verified positive drug test. DEA lost trust in Mr. Armour and properly removed him.”
Despite a years-long fight to keep Agent Armour off the payroll the DEA has agreed to reinstate him and pay him $470,000 in back pay and legal fees, according to the New York Times who obtained a copy of the court filings from earlier this month. Agent Armour told the New York Times he still sees value in using CBD for pain management but that he will consult a medical professional for viable alternatives upon his return to work.
“Federal drug testing policies—and importantly, attitudes about drug testing—have not caught up with the times. I’m not the only career law enforcement officer in this country with chronic pain, nor am I the only law enforcement officer that has turned to legal cannabis products to address pain,” Agent Armour said in court testimony in September. “Nobody should have to choose between suffering pain and serving our country.”
… 2021 armed robbery of a marijuana dealer in San Bernardino, which … .M.” – for one pound of marijuana. Jones placed the order knowing … and Jones then stole the marijuana and a firearm belonging to …
BOSTON–(BUSINESS WIRE)–Manatt, Phelps & Phillips, LLP, a multidisciplinary, integrated professional services firm, today announced the arrival of National Advisor Tim Andrews to the Firm’s Boston office and national Digital and Technology group. With experience that cuts across digital transformation in industries ranging from health care, life sciences and biotech to digital media and technology, Andrews works with C-level executives—including Chief Technology Officers, Chief Information
