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Tag: Budgets and Funding

  • UNC ObGyn, Orange County Department of Health Receive Funding to Reduce Inequities in Maternal Health Care and Outcomes

    UNC ObGyn, Orange County Department of Health Receive Funding to Reduce Inequities in Maternal Health Care and Outcomes

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    Newswise — A study between the UNC Chapel-Hill and Orange County Health Department, called “Thriving Hearts: Healing-Centered, Integrated, Community Maternity Care,” has been approved for a $21-million funding award from the Patient-Centered Outcomes Research Institute (PCORI), an independent, nonprofit organization based in Washington, D.C. The funding award will be used to reduce the incidence of hypertensive disorders of pregnancy (HDP) and improve maternal outcomes across 10 North Carolina counties over the next six years.

    In the United States, rates of maternal mortality and severe maternal morbidity are rising, especially among Black and American Indian/Alaska Native women and women with disabilities, low incomes, or rural residences. Black women with HDP – a group of high blood pressure disorders that includes preeclampsia and gestational hypertension – are 3.7 times more likely to die from complications and are more likely to experience severe morbidity than their white counterparts.

    The project, led by Alison Stuebe, MD, professor of obstetrics and gynecology at the UNC School of Medicine, and Quintana Stewart, director of Orange County’s Health Department, will be coordinating with local health departments, families, and community groups to make pregnancy and birth safer. Their project strategy involves a multi-level intervention to provide support and connection at the individual patient level, the healthcare team level, and the community level.

    “The overarching goal of ‘Thriving Hearts’ is to cultivate conditions for mothers to not only survive pregnancy, but to thrive,” said Stuebe, who is also a Distinguished Scholar of Infant and Young Child Feeding at UNC Gillings School of Global Public Health. “By implementing a multi-level intervention, we want to help community advocates, health system leaders, and policymakers understand what types of support matter to growing families.”

    A Multi-Level Intervention

    The intervention will be delivered by local health departments in Alamance, Caswell, Chatham, Cumberland, Durham, Forsyth, Guilford, Johnston, Orange, and Person Counties, with the goal of strengthening the ecosystem for pregnant and parenting people across each county.

    Local health department staff will be supported to work with maternity care practices in their county to implement home blood pressure monitoring, provide healing-centered support for the health care workforce, and meet the emotional, social, and logistical needs of county residents.

    In addition to health department staff, the project team is comprised of people with lived experience of HDP, including doulas, community health workers, dieticians, social workers, nurses, and researchers. The team will be providing community-informed, multicomponent interventions that simultaneously address health conditions and social determinants of health at the individual, healthcare provider, and community level.

    At the individual level, members of the team will support prenatal clinic staff to determine patients’ risk for developing HDP. Women at high risk will receive a care kit that includes blood pressure-checking tips, a home blood pressure monitor, and a bottle of low-dose aspirin to prevent HDP. They will also be able to sign up for free informational text messages.

    Team members will also be deployed to local hospitals and clinics to provide workshops on burnout and compassion fatigue for health department staff and community healthcare providers. Along with providing small grants to neighborhood organizations, the team’s community health workers will be contacting pregnant women to introduce them to local resources and events and offering referrals to a Medical Legal Partnership to help solve problems like unsafe housing.

    The Five-Year Comparative Effectiveness Study

    Researchers will conduct a five-year study to see how well the Thriving Hearts program works. They will track the progress of the participants – about 140,000 women – before and after the Thriving Hearts program begins.

    Using hospital records, insurance claims, and birth certificates, the team will track how many women get HDP, and how well the program prevented HDP from developing. About three months after birth, the team will survey the participants about their health, well-being, and care. Healthcare workers will also be surveyed to see if their burnout lessened after their county has the Thriving Hearts program.

    Finally, the team will assess how well counties took to Thriving Hearts, and what particular elements were difficult to implement by speaking with patients, community groups, and health team members.

    The funding award for the Thriving Hearts study has been approved pending completion of a business and programmatic review by PCORI staff and issuance of a formal award contract.

     

    About Orange County Health Department

    The mission of Orange County Health Department (OCHD) is to promote and protect health, enhance quality of life, and preserve the environment for everyone in Orange County. In 2023, North Carolina Local Health Department Accreditation (NCLHDA) Board awarded OCHD Reaccreditation with Honors, highlighted two unique programs during their visit: Family Success Alliance (FSA), which serves families to break the cycle of poverty, and the Gateway Collaborative, which offers services in the Gateway Village housing community with the goal of bringing agencies together to support residents.

     

    About UNC School of Medicine

    The UNC School of Medicine (SOM) is the state’s largest medical school, graduating more than 180 new physicians each year. It is consistently ranked among the top medical schools in the US, including 5th overall for primary care by US News & World Report, and 6th for research among public universities. More than half of the school’s 1,700 faculty members served as principal investigators on active research awards in 2021. Two UNC SOM faculty members have earned Nobel Prize awards.

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    University of North Carolina School of Medicine

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  • Texas A&M begins construction on Animal Reproductive Biotechnology Center

    Texas A&M begins construction on Animal Reproductive Biotechnology Center

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    Newswise — Texas A&M AgriLife Research hosted leaders from across The Texas A&M University System in a groundbreaking ceremony of the new Animal Reproductive Biotechnology Center at Texas A&M-RELLIS, a 2,400-acre applied research campus in Bryan.

    The $13 million facility is a joint construction project of AgriLife Research and the Texas A&M College of Agriculture and Life Sciences Department of Animal Science, with completion expected in 2025.

    The center will be integral to new opportunities for advancing collaborative research, teaching and outreach in the department while supporting an overarching vision of leading the science around animal pregnancy and development.

    “The beginning of this construction is another step in carrying out the land-grant mission across The Texas A&M University System,” said Chancellor John Sharp. “This technologically advanced facility will keep Texas A&M at the forefront in advancements in animal expertise and propel innovative, science-based solutions that lead the industry in overcoming challenges.”

    “Innovations in livestock reproduction are crucial to agriculture in Texas, and this building will be an important part of the big ‘ecosystem’ of agriculture and life sciences at Texas A&M,” said Jeffrey W. Savell, Ph.D., vice chancellor and dean for Agriculture and Life Sciences. “This new facility will move research forward and will help train producers and students to carry on this work into the future.”

     

    Anticipated impacts on livestock reproduction

    The new center will be fundamental to increased understanding of ruminant reproduction at molecular, cellular and whole-animal levels while continuing work to address known reproductive issues. It will serve to advance innovation and collaboration through industry-partnered research focusing on the latest techniques and technologies that optimize reproductive efficiency and minimize economic loss for producers.

    G. Cliff Lamb, Ph.D., director of AgriLife Research, said the new center dovetails with a string of advancements across the state research agency that contributed to a near doubling of competitive awards in fiscal year 2023. He also cited the establishment of several interdisciplinary initiatives to solve overarching challenges facing Texas commodities.

    “This facility will be a major boost to translational research for sustainable livestock systems,” Lamb said. “It is critically important that we generate science our partners can trust and apply, and which nourish healthy lives, livelihoods and economies.”

     

    A technologically advanced campus

    The center will house labs, educational spaces, office space, and animal holding and handling areas separated by size and ruminant type. Designated areas for each group will include chutes for specimen collection, stanchion space for hands-on instruction, and preparation and recovery spaces for small ruminants. These workspaces will be supported by load-out areas, holding pens and alleyway circulation.

    “It is exciting to envision what we can discover, and the lives we will improve, as a result of the work at this new facility,” said Clay Mathis, Ph.D., head of the Department of Animal Science. “This facility will further empower our exceptional team of experts to make new discoveries and open up new experiences for students.”

    “It’s an exciting day to be an Aggie, a faculty member and a student at Texas A&M,” said Ky Pohler, Ph.D., associate professor in the Department of Animal Science. “This one-of-a-kind space brings together the latest reproductive technologies under one roof to support research and hands-on teaching. There is no other space like this that exists in the U.S.”

     

    Giving to the Animal Reproductive Biotechnology Center

    Gifts from industry members have helped transition the center from an idea to reality.

    The Texas A&M Foundation is a nonprofit organization that exists to the benefit of Texas A&M University. The Foundation works with former students, corporations and other Texas A&M supporters to match their charitable interests with the university’s priorities. Gifts create scholarships, advance faculty endeavors, enhance student programs and fund new buildings, ultimately creating a brighter future for Texas A&M, one relationship at a time.

    To donate to the new Animal Reproductive Biotechnology Center, go to http://give.am/ANSCConstructionFund or contact Jansen Merrill, director of development, at 979-845-7594.

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    Would you like more information from Texas A&M AgriLife?

    Visit AgriLife Today, the news hub for Texas A&M AgriLife, which brings together a college and four state agencies focused on agriculture and life sciences within The Texas A&M University System, or sign up for our Texas A&M AgriLife E-Newsletter.

    For more resources including photo repository, logo downloads and style guidelines, please visit the Resources for Press and Media.

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    Texas A&M AgriLife

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  • Developing carbon-negative cementitious materials, giving new life to ‘unusable’ waste

    Developing carbon-negative cementitious materials, giving new life to ‘unusable’ waste

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    Newswise — ROLLA, Mo. – A Missouri University of Science and Technology research team was recently awarded $2.5 million in funding to find new ways to turn waste products into supplementary cementitious materials (SCMs) – plus use those materials to store carbon permanently in concrete.

    “Years ago, SCMs were used as a cheap option to replace some Portland cement and also have a stronger and more durable concrete mixture,” says Dr. Hongyan Ma, Francisco Benavides Scholar and associate professor of civil engineering at S&T. “There is now a severe shortage of these materials, so my team is looking at creative ways to develop new alternatives that are carbon-negative and will make the industry greener.”

    Ma also serves as director of S&T’s Laboratory of Future Cements and Carbon-Negative Initiatives.

    He says one of the most common SCMs has traditionally been coal combustion residue, or fly ash, but a large percentage of this type of waste is not currently usable in cement. According to the Electric Power Research Institute, 2.5 billion tons of this type of waste have been disposed of in ponds and landfills throughout the United States.

    Ma’s two-year research project, which received a $2 million grant from the U.S. Department of Energy and $500,000 in matching funds from S&T and industry partners, aims to make this unusable waste into something of value.

    The research will also cover the ash from municipal solid waste incinerators, steel slag, recycled concrete and other waste products. The team is currently developing processes to break down the structure of the solid wastes in ways that will also allow them to store CO2.

    The carbon that is combined with these new SCMs will primarily come from the flue gases of power plants and the manufacturing industry, Ma says. By using COdirectly from the flue gasses, as long as the concentration is high enough, his team will not have to use energy-intensive carbon-capture methods.

    Ma says this project is designed to make a significant difference in the concrete industry in the near future, as opposed to focusing on more general, long-term concepts.

    “The work we are conducting is mission-oriented,” he says. “Part of our research is to make sure what we develop is economically feasible. It can’t be too expensive, as it needs to be a realistic option to support the supply chain.”

    Ma is the project’s principal investigator (PI). Serving as his co-PIs at Missouri S&T are: Dr. Aditya Kumar, associate professor of materials science and engineering; Dr. Mahelet Fikru, associate professor of economics; and Dr. Wenyu Liao, assistant research professor of civil engineering. Lawrence Livermore National Laboratory is also collaborating with S&T for the project.

    For more information about Missouri S&T’s civil engineering programs, visit care.mst.edu.

    About Missouri University of Science and Technology 
    Missouri University of Science and Technology (Missouri S&T) is a STEM-focused research university of over 7,000 students located in Rolla, Missouri. Part of the four-campus University of Missouri System, Missouri S&T offers over 100 degrees in 40 areas of study and is among the nation’s top public universities for salary impact, according to the Wall Street Journal. For more information about Missouri S&T, visit www.mst.edu.

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    Missouri University of Science and Technology

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  • UTHealth Houston researchers awarded $2.6M NIH grant to study molecular pathways and potential strategies for treatment of myocardial ischemia and reperfusion injury

    UTHealth Houston researchers awarded $2.6M NIH grant to study molecular pathways and potential strategies for treatment of myocardial ischemia and reperfusion injury

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    Newswise — A four-year, $2.6 million grant to study circadian rhythm and novel therapies to protect the heart during a heart attack or cardiac surgery has been awarded to UTHealth Houston by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health.

    Principal investigator Holger Eltzschig, MD, PhD, professor, and co-investigator Wei Ruan, MD, PhD, assistant professor, from the Department of Anesthesiology, Critical Care and Pain Medicine at McGovern Medical School at UTHealth Houston, are studying translational, pharmacologic, and interventional strategies targeting circadian rhythm and hypoxia signaling that could help patients who are experiencing a heart attack or undergoing open-heart surgery.

    Previously published research in 2012 and 2021 by Eltzschig and Ruan showed that biological rhythms affect myocardial ischemia and reperfusion injury (IRI) severity. IRI can occur in the setting of a heart attack, open-heart surgery, or during circulatory arrest, where blood flow is temporarily cut off (ischemia). During this period, the affected heart tissues suffer from inadequate oxygen supply (hypoxia). Once the obstruction is removed and blood flow resumes (reperfusion), rather than bringing immediate relief, this sudden influx of blood can lead to additional stress and damage to the heart.  

    The previous research further indicated that larger infarctions or higher incidences of heart failure happen in patients with morning onset heart attacks rather than later in the day. This daytime variation of myocardial injury hints at a potential interaction between circadian rhythm and hypoxia signaling.

    “My laboratory has been very interested in studying IRI for over two decades,” said Eltzschig, the John P. and Kathrine G. McGovern Distinguished University Chair and the director of the Center for Perioperative Medicine at McGovern Medical School. “We undertook an unbiased look to understand the molecular mechanisms of why there are differences in heart attacks in the early morning versus the late afternoon.”

    In studies that led up to the current grant application, the team of scientists analyzed heart tissue samples from circadian rhythm-trained mice following heart attacks at different time points of the day. In addition, they analyzed samples derived from the left heart ventricle of patients undergoing cardiac surgery at different times of the day. They identified a highly differentially expressed gene, BMAL1, a core circadian transcription factor. The genetic deletion of BMAL1 in mouse hearts eliminates daytime variations in cardiac injury.

    Natural protective molecules called hypoxia-inducible factors (HIFs) are activated due to a lack of oxygen and promote the adaptation to limited oxygen availability. In addition, HIFs limit excessive tissue inflammation in order to prevent further tissue damage. Specifically, researchers uncovered that HIF2A works together with BMAL1 in heart tissues to provide circadian-dependent heart protection.

    With this grant, researchers will aim to understand how BMAL1 and HIF2A interact and their functional roles in modulating daytime variation of cardiac injury. High-resolution imaging techniques will be employed to study the molecular interactions between BMAL1 and HIF2A by Kuang-Lei Tsai, PhD, co-principal investigator and assistant professor, and postdoctoral researcher Tao Li, PhD, from the Department of Biochemistry and Molecular Biology at McGovern Medical School. They will further explore the possibility of targeting the BMAL1 and HIF2A pathways as therapeutic strategies to protect the heart from injuries during surgery.

    “We are using data to see if the pathways and transcriptional regulations are occurring in patients undergoing cardiac surgery in the morning or the afternoon,” Eltzschig said.

    The other co-principal investigator of the study is Jochen Daniel Muehlschlegel, MD, MMSc, MBA, professor and chair of the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University. NIH Grant R01HL165748 funds this research.

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    University of Texas Health Science Center at Houston

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  • Not all donors are billionaires: Expert suggests new approach for teaching philanthropy

    Not all donors are billionaires: Expert suggests new approach for teaching philanthropy

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    Not all donors are billionaires, but many faculty teach philanthropy by focusing on wealthy donors. With National Philanthropy Day on Monday, Nov. 12, David Campbell, professor of public administration at Binghamton University, State University of New York, suggests a different approach for teaching philanthropy to young people.

    “Many faculty teach experiential philanthropy courses through the lens of debates about giving largely shaped by the assessment of the role wealthy donors play in civic life. But most of our students will NOT become billionaire (or millionaire donors); rather, they are likely (we hope) simply to become generous individuals, who give regularly to support the issues that are important to them. For me, this has meant reorienting my classes to ask students several core questions and to get them to focus on these questions over the course of the semester:  

    • What responsibility do you (we) have to give to your community?  
    • What core values and experiences motivate your giving? 
    • What would it take to make giving a regular part of your life?  (For students, this is hard, because they are students, and don’t yet have any money to give away)?  
    • What are ways that people of limited means can be generous and still make a difference?”  

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    Binghamton University, State University of New York

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  • Internal crowdfunding unlocks innovation and employee engagement

    Internal crowdfunding unlocks innovation and employee engagement

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    Newswise — In a several-round-long crowdfunding initiative, the employees of Siemens AG not only had the opportunity to present their own ideas on an in-house online platform; in the role of investors, they were also able to choose which projects to implement. In other words, they had a chance to do things normally reserved for managers: make decisions and allocate budgets. The researchers assessed how well this distributed decision-making approach worked and the corresponding role of hierarchies. Their conclusion: “Employees submitted high-quality ideas, which their colleagues recognized and financially supported,” says Christina Raasch, a Professor of Digital Economy at KLU and researcher at Kiel Institute for the World Economy (IfW).

    However, these investors weren’t wholly unbiased; they tended to support the ideas of employees at their own hierarchical level. As Raasch explains: “Similarities with the person who submitted it increased their identification with the idea and promoted a sense of group identity, leading to a more positive evaluation.” And the more innovative the idea was, the more pronounced this effect was. In contrast, when investors and creators were competitors, the amounts invested tended to be smaller.

    Tapping hidden know-how and fostering employee loyalty

    Nevertheless, at the end of the day, the advantages of idea competitions with distributed decision-making are self-evident: They allow in-house know-how that is distributed throughout the company and perhaps going to waste to be tapped, while also promoting exchanges and collaboration across internal borders. “In addition, we observed that employee loyalty and motivation improved when their ideas were appreciated and their decisions were respected – the management had no veto power,” Raasch reports. Further, the approach helps to manage larger numbers of ideas, since there are more shoulders to bear the burden.

    Viable paths to joint innovation

    To ensure that companies and employees alike reap the maximum benefits of internal crowdfunding, the processes involved have to be carefully thought through and adapted to the company in question. To ensure the investors aren’t overwhelmed with too many ideas, larger companies should form smaller groups of creators. The management has to stand behind the idea of putting decision-making power in the hands of employees – and can’t snatch it back later. It also needs to be clear where the money the investors are meant to allocate comes from. In most cases, creators want to present their idea together with their own name. Christina Raasch explains why: “This kind of visibility boosts motivation and satisfaction for everyone involved – which is more important than any minor skewing affects in the evaluation.”

    Any company that wants to be innovative and foster new ideas also has to ensure that, if an idea fails, it has no negative consequences for either the creator or the investors; rather, it has to be part of the company’s learning culture. After all, innovations always involve a degree of risk. Another important factor is whether or not investors are anonymous: When investors’ identities are known, they tend to evaluate more thoroughly, but are also more cautious and could be put under pressure by creators. “Another possibility would be to only reveal the identities of the investors for ideas that are implemented,” Raasch suggests. “But I normally recommend permanent anonymity to avoid any potential fallout for investors.”

    How the study was conducted

    Since 2015, Siemens has implemented nine rounds of financing with internal crowdfunding. Here’s how it works: Employees submit their ideas for projects, together with the projected benefits for the company, on a shared platform. All employees can “like” the ideas and share their feedback. Up to a given deadline, creators can continuously refine their projects. Then, a limited number of anonymous investors – all employees are eligible to sign up, and the investors are selected at random – receive a budget, assess the ideas, and are free to allocate funding in 1-euro increments. Those ideas that reach their funding target are green-lighted.

    The team of researchers analyzed the data from the idea platform in anonymized form, assessing e.g. how new the ideas were, the investment choices made, and the hierarchical levels involved – factors that were integrated into the study. In addition, they spoke with creators, investors and managers, and conducted an online survey of employee perceptions of the platform’s benefits. The resulting information offered them deeper insights into internal crowdfunding at Siemens. 

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    Kuhne Logistics University

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  • Can Lifestyle Interventions Benefit Patients With Advanced Breast Cancer?

    Can Lifestyle Interventions Benefit Patients With Advanced Breast Cancer?

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    Newswise — MIAMI, FLORIDA (Oct. 17, 2023) – Can lifestyle interventions such as exercise and intermittent fasting help patients with advanced breast cancer better tolerate side effects from treatment?

    That is the question Tracy Crane, PhD, RDN,  and Carmen Calfa, MD, at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and their collaborators will strive to answer with a $4-million, five-year grant from the National Cancer Institute (NCI).

    Crane, co-lead of Cancer Control and director of Lifestyle Medicine, Prevention and Digital Health at Sylvester, is multiple principal investigator, along with Christina Dieli-Conwright, PhD, and Jennifer Ligibel, MD, from Dana Farber Cancer Institute. Calfa, medical co-director of Cancer Survivorship and Translational Behavioral Sciences at Sylvester, is co-investigator for this phase II, randomized trial, which will include 260 women with advanced breast cancer. The trial is being conducted in English and Spanish and focuses on women starting a CDK4/6 inhibitor medication in combination with hormonal therapy. Researchers hypothesize that the prolonged overnight fasting with and without exercise during daylight hours will help with alignment of circadian activity rhythms and ultimately improve levels of fatigue. Circadian activity rhythms include sleep/wake cycles and physical activity and disruption of these significantly disturbs homeostasis of a variety of biological and metabolic processes including immune function, cellular aging and death.

    Crane said it will build on a recently completed pilot study among 30 women with advanced breast cancer demonstrating that prolonged overnight fasting, a type of intermittent fasting, and exercise interventions were well tolerated and led to reduced fatigue and improved quality of life.

    “We know from previous studies of patients with early breast cancer that lifestyle interventions can reduce fatigue, improve physical function and lessen the impact of other treatment-related side effects,” Crane said. “However, there are few studies and limited data about the impact of exercise and dietary interventions on patients living with advanced breast cancer.”

    About 300,000 new cases of invasive breast cancer are diagnosed every year and about 40,000 women die of metastatic disease, even though treatment for breast cancer has improved significantly in recent years.

    “Although patients are living longer than ever with advanced breast cancer, newer targeted therapies can cause significant side effects, including fatigue, decreased immune defense as well as gastrointestinal symptoms, Calfa explained. “Additionally, hormonal treatments used in combination with targeted therapies can result in menopausal symptoms, mood disorders and impaired sleep.”

    “For some patients,” she added, “the side effects can become debilitating, resulting in them discontinuing treatment and subsequently compromising their oncological outcome. Empowering women with lifestyle interventions that allow them to take charge and drive a positive outcome is essential and I m delighted to take part in this important project.”

    In this study, researchers will evaluate the effectiveness of supervised exercise and prolonged overnight fasting, alone or in combination, on fatigue, biomarkers of inflammation, sleep quality, physical function, body composition and patient-reported outcomes related to depression, anxiety and quality of life versus those in an attention-control supportive care group.

    Outcomes will be assessed 12 weeks after patients enroll in the trial and then again at six and 12 months.

    With October being Breast Cancer Awareness Month, Crane believes the trial’s timing is fortuitous for women living with advanced breast cancer.

    “Our research has the potential to improve treatment tolerability, quality of life and possibly life duration for women living with advanced breast cancer,” Crane said. “Those are the most meaningful outcomes for these women.”

    Enrollment in the study is anticipated to open in early 2024. For more information, check the Crane Lab website.

    Read more about this study on the InventUM blog.

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    Sylvester Comprehensive Cancer Center

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  • NIH awards researchers $1.2M to develop robotic eye examination system

    NIH awards researchers $1.2M to develop robotic eye examination system

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    Newswise — A collaboration between researchers at the University of Illinois Urbana-Champaign and Duke University has developed a robotic eye examination system, and the National Institutes of Health has awarded the researchers $1.2 million to expand and refine the system.

    The researchers have developed a robotic system that automatically positions examination sensors to scan human eyes. It currently uses an optical scan technique which can operate from a reasonably safe distance from the eye, and now the researchers are working to add more features that will help it perform most steps of a standard eye exam. These features will require the system to operate in closer proximity to the eye.

    “Instead of having to spend time in a doctor’s office going through the manual steps of routine examinations, a robotic system can do this automatically,” said Kris Hauser, a U. of I. computer science professor and the study’s principal investigator. “This would mean faster and more widespread screening leading to better health outcomes for more people. But to achieve this, we need to develop safer and more reliable controls, and this award allows us to do just that.”

    Automated medical examinations could both make routine medical services accessible to more people and allow health care workers to treat more patients. However, medical examinations present unique safety concerns compared to other automated processes. The robots must be trusted to operate reliably and safely in proximity to sensitive body parts.

    A prior system developed by Hauser and his collaborators was a robotic eye examination system that deploys a technique called optical coherence tomography which scans the eye to create a three-dimensional map of the eye’s interior. This capability allows many conditions to be diagnosed, but the researchers want to expand the system’s capabilities by including a slit eye examiner and an aberrometer. These additional features require the robot arm to be held within two centimeters of the eye, highlighting the need for enhanced robotic safety.

    “Getting the robot within two centimeters of the patient’s eye while ensuring safety is a bit of a new concern,” Hauser said. “If a patient’s moving towards the robot, it has to move away. If the patient is swaying, the arm has to match their movement.”

    Hauser likened the control system to those used in autonomous vehicles. While the system can’t react to all possible human behaviors, he said, it must prevent “at-fault collisions” like self-driving cars must do.

    The award will enable the researchers to conduct large-scale reliability testing. An important component of these tests is ensuring that the system works for as many people as possible. To achieve this, the researchers have developed a second robot that will use mannequin heads to emulate unexpected human behaviors. Moreover, the second robot will automatically randomize the heads’ appearance with different skin tones, facial features, hair and coverings to help the researchers understand and mitigate the effects of algorithmic bias in their system.

    The system will be designed for use in clinical settings, but Hauser imagines that one day such systems could be used in retail settings much like blood pressure stations.

    “Something like this could be used in an eyeglass store to scan your eyes for the prescription, or it could give a diagnostic scan in a pharmacy and forward the information to your doctor,” he said. “This is really where an automated examination system like this would be most effective: giving as many people access to basic health care services as possible.”

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    Duke University professors Jospeh Izatt of biomedical engineering and Anthony Kuo of ophthalmology are co-principal investigators.

    The award, cosponsored by the National Robotics Initiative, will be distributed over three years.

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    University Of Illinois Grainger College Of Engineering

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  • NSF grant awarded for development of method to recover rare-earth elements from U.S. mines

    NSF grant awarded for development of method to recover rare-earth elements from U.S. mines

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    Newswise — The National Science Foundation (NSF) has awarded a $2 million grant to researchers who are developing new functional materials to separate and recover rare-earth elements and platinum group metals from waste streams of U.S. mines. These critical elements – which are required materials for widely-used products like smartphones and LED lights – are currently largely mined and processed by other countries.

    Chemical & Biomolecular Engineering (ChBE) professor Xiao Su at the University of Illinois Urbana-Champaign leads the project. UIUC professors Diwakar Shukla (ChBE), Alexander Mironenko (ChBE) and Prashant Jain (Chemistry), and Michelle Calabrese (professor in Chemical Engineering & Materials Science at University of Minnesota) are co-Principal Investigators on the project.

    According to the researchers, there is potential for the U.S. to significantly ramp up its production of both rare-earth elements and platinum group metals, as well as secure its supply-chain, through more efficient and sustainable processes for recovery and recycling. Recovery of rare-earth metals and platinum group metals from the waste streams of U.S. mines is currently difficult because they are found as dilute ions in a complex mixture of elements. To address this challenge, the team will develop new polymer-based electrode materials to capture the elements in a way that is highly selective yet reversible, and implement electrically-driven separation processes for sustainable recovery and purification. The researchers combine expertise in machine-learning, molecular dynamics and electronic structure calculations, materials synthesis, characterization, and processing, as well as separation processes.

    “Our aim is to accelerate the discovery of new materials for electrochemical separations through a closed-loop iteration between simulations and experiments,” Su said. “We seek to move beyond a trial-and-error approach for materials design and testing, and establish for the first time a rational framework for creating new redox-polymers tailored for the sustainable electrochemical recovery of critical elements.”

    The grant is administered by NSF’s Designing Materials to Revolutionize and Engineer our Future program. More information about this project, Rational design of redox-responsive materials for critical element separations, is available here. UIUC received $1.6 million in funding, and University of Minnesota received $400,000.

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    University Of Illinois Grainger College Of Engineering

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  • U.S. Department of Energy Selects Team to Advance Fusion Research

    U.S. Department of Energy Selects Team to Advance Fusion Research

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    Newswise — The U.S. Department of Energy (DOE) has announced its selection of a multi-institutional team of data scientists from General Atomics (GA), the San Diego Supercomputer Center (SDSC) and UC San Diego, Hewlett Packard Enterprise (HPE) and Sapientai to develop a Fusion Data Platform (FDP) for advancing high-priority fusion research. In support of this effort the DOE awarded the team a three-year, $7.4 million grant.

    Led by GA, the FDP initially will be deployed at SDSC, located at the University of California San Diego. Once completed, the FDP will be made available to the scientific community to provide access to high-quality fusion data for the efficient creation of reproducible artificial intelligence (AI)/machine learning (ML) models to support the design and operation of a broad range of fusion pilot plants (FPP) designs and plasma configurations within a decadal timescale.

    A suite of AI/ML modeling capabilities developed by Sapientai and UC San Diego computer science and engineering faculty Rose Yu and Sicun Gao will be integrated with the platform, allowing it to serve as a powerful data and analysis tool that meets the growing needs of the fusion science community. 

    “Creating a robust AI/ML platform with very large curated datasets and efficient processing tools will be transformational for fusion energy,” said Brian Sammuli, head of the Fusion Data Science Center at GA and principal investigator. “By advancing AI/ML research in fusion, we will be able to rapidly address many of the remaining challenges in fusion science and reactor development. We look forward to leading this team to provide an outstanding platform for the scientific community to advance fusion research and support the deployment of the first generation of fusion energy power plants.”

    According to Raffi Nazikian, senior director and leader of the ITER Research Hub at GA, a key mission of the FDP is to accelerate AI/ML research by expanding access to high-quality fusion data and the tools needed to process the data at scale.

    “The FDP will include experimental and simulated data in an integrated platform. We are talking many petabytes of data that will be easily accessible on the platform,” said Nazikian. “The success of the FDP will be measured by how well we serve the needs of the fusion and broader data science community, including students and researchers from universities, national laboratories and industry.”  

    SDSC Director Frank Würthwein, professor in the Department of Physics and at the Halıcıoğlu Data Science Institute at UC San Diego, said that the FDP is an important step toward  harnessing the power of fusion data to advance the development of fusion energy.

    “GA and SDSC have a long history dating back almost 40 years, and this is the beginning of a new chapter in our cooperation to advance fusion energy science and education,” Würthwein noted.

    Paolo Faraboschi, HPE fellow and AI Research Lab director at Hewlett Packard Labs, said that his team is excited to help build a powerful data platform for fusion. “Among the FDP unique capabilities will be the ability for users to access, understand and leverage prior data and AI pipelines to advance their research and build reproducible, certifiable AI/ML models. We look forward to working with the scientific community on the FDP to help realize the decadal vision for fusion energy development.”

    Craig Michoski, founder and CEO of Sapientai, also noted his group’s excitement to participate in the FDP project. “This is a phenomenal set of collaborative institutions, and we have high aspirations for the success and impact the FDP project will have across the fusion landscape,” he said. “We think the era of data-driven science and technology advancement is well upon us, and we are extremely excited to see how these tools applied to the treasure trove of DOE’s fusion data can advance the field and accelerate progress towards commercial fusion energy.”

    Supporting Data-Informed FPP Designs

    To achieve fusion conditions relevant for energy production, an FPP must sustain plasmas at temperatures exceeding 100 million degrees Celsius—approximately 10 times the temperature at the center of the sun. In magnetic confinement fusion, plasmas are controlled using powerful electromagnets that shape and confine the superheated gas. At such extreme temperatures, the plasmas may exhibit instabilities that may cause them to momentarily breach the magnetic fields and interact with the inner walls of the fusion machine, which could decrease efficiency or even cause damage. Successfully designing FPPs that account for these and other types of instabilities requires robust data sets to model and predict plasma behaviors across designs.

    The FDP will help to address this need by making large-scale fusion data easier to access and analyze. The multi-institutional team will draw from its significant AI/ML industry expertise to develop the FDP as a resource capable of being collectively utilized across distributed computational facilities.

    The FDP will leverage GA’s scaleable, fusion-specific data processing tool, TokSearch, to process and curate the data sets at the required scale. The team will also draw from HPE’s Common Metadata Framework to create reproducible workflows that include metadata tracking, source code integration, and data version control. A publishing portal will be incorporated into the system to facilitate search and discovery of these curated datasets. A suite of AI/ML modeling capabilities developed by Sapientai and UC San Diego will be integrated with the platform, allowing it to serve as a powerful data and analysis tool that meets the growing needs of the fusion science community.

    About the Team

    The San Diego Supercomputer Center was established in 1985 as one of the nation’s first supercomputer centers under a cooperative agreement by the National Science Foundation in collaboration with UC San Diego and GA. SDSC provides resources, services and expertise to the national research community, including industry and academia, and features the Expanse, Voyager and National Research Platform supercomputers and innovative computing systems. Expanse supports SDSC’s theme of “Computing without Boundaries” with a data-centric architecture, public cloud integration and state-of-the art GPUs for incorporating experimental facilities and edge computing. The first-of-its-kind experimental system with training and inference accelerators to provide high-performance, high-efficiency AI compute, Voyager supports AI research across a range of science and engineering domains. The National Research Platform provides a nationally distributed data and compute platform with GPUs and FPGAs for AI, and a content delivery system with data caches in the internet backbone across four continents. 

    Hewlett Packard Enterprise is the global edge-to-cloud company that helps organizations accelerate outcomes by unlocking value from all their data, everywhere. Built on decades of reimagining the future and innovating to advance the way people live and work, HPE delivers unique, open and intelligent technology solutions as a service.

    Sapientai LLC combines ML and AI with data-intensive science, notably in nuclear fusion and plasma physics. They provide versatile software solutions, including off-the-shelf applications as well as tailored services. With a firm belief in collaboration, Sapientai encourages innovative research partnerships. Their work aligns with the Department of Energy’s mission, committed to advancing scientific frontiers.

    Since the dawn of the atomic age, General Atomics innovations have advanced the state of the art across the full spectrum of science and technology – from nuclear energy and defense to medicine and high-performance computing. Behind a talented global team of scientists, engineers, and professionals, GA’s unique experience and capabilities continue to deliver safe, sustainable, economical, and innovative solutions to meet growing global demands.

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  • T. Boone Pickens Foundation Donates $20 Million to Wilmer Eye Institute, Johns Hopkins Medicine

    T. Boone Pickens Foundation Donates $20 Million to Wilmer Eye Institute, Johns Hopkins Medicine

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    Newswise — The T. Boone Pickens Foundation, established by the late, Texan innovative energy leader and philanthropist, is donating $20 million to the Wilmer Eye Institute, Johns Hopkins Medicine. The gift, announced in 2013, is one of the largest research donations in Wilmer’s history. It will fund vision-saving research and a professorship.

    Pickens’ interest in the treatment and research of eye conditions developed in the 1980s after his father’s diagnosis of macular degeneration, a progressive condition that disrupts the central field of vision and causes vision loss. At the time, no treatments existed to prevent decline of his father’s healthy vision.

    Pickens later publicly disclosed his own battle with macular degeneration and sought treatment from Wilmer for both this condition and cataracts. His care team, which included Walter Stark, M.D., and Neil Bressler, M.D., and which used the latest and most advanced treatments, was able to help Pickens retain most of his eyesight until his death in 2019 at the age of 91.

    “Walter Stark, like my dad, had deep Oklahoma roots,” says Pickens’ daughter, Liz Cordia. “They became fast friends. This friendship ultimately evolved into Walter treating my grandad’s glaucoma and my dad’s cataracts and later diagnosing his macular degeneration.”

    In 2005 and 2009, Pickens made gifts totaling $8 million — first to establish the Boone Pickens Professorship of Ophthalmology, currently held by Amir Kashani, M.D., Ph.D., and then to help with construction of the Robert H. and Clarice Smith Building to house Wilmer’s research laboratories and state of the art operating rooms.

    “Mr. Pickens’ generous contributions to Wilmer will serve as the foundation on which teams of clinicians, scientists and engineers will develop novel diagnostic and therapeutic interventions to prevent blindness and improve the health of people around the world,” says Kashani.

    Along with cutting-edge research and the Boone Pickens Professorship, the $20 million gift from the Pickens Foundation will endow additional Boone Pickens Professorships, specifically for young investigators, called Rising Professorships. The funds will be allocated to researchers who conduct novel, vision-saving research that may be overlooked by other potential funding opportunities.

    ”The Pickens Rising Professors will be our best and brightest physician-scientists who are early in their careers and exploring their new ideas for improving the care of patients and ending blinding eye diseases” says Peter McDonnell, M.D., Wilmer’s director. “This transformative gift from our friend, Mr. Pickens, will accelerate our work in artificial intelligence, stem cells, nanotechnology and other exciting new frontiers.”

    The gift comes after Cordia and Jay Rosser, a foundation representative, visited Wilmer leaders and researchers early this summer to discuss how the donation would be used at the institute and new research spaces under construction at Johns Hopkins.

    “Advancing health and medical initiatives that would have impacts spanning generations was a core objective in Boone’s giving,” says Rosser. “When all is said and done, his philanthropic impact exceeded $1 billion and was directed at some of the world’s most cutting-edge research institutions, and the Wilmer Eye Institute stands high on that list.”

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  • ASBMB calls for student loan relief

    ASBMB calls for student loan relief

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    Newswise — On June 20, the American Society for Biochemistry and Molecular Biology submitted public hearing testimony to the Department of Education expressing concerns about the growing burden of student loan debt. The society called for expanding debt-relief programs across all educational levels and allowing postdoctoral researchers to defer loan payments until after completion of their training.

    “We are in the midst of a student debt crisis, and it’s hurting the research enterprise and more importantly, the next generation of scientists,” Sarina Neote, ASBMB public affairs director, said. “The average student debt balance has more than doubled in the past two decades, and this increase is coming at the expense of inclusivity. Student debt disproportionately affects underrepresented groups like Black, Latinx and American Indian students; the scientific workforce and enterprise will narrow and suffer if relief doesn’t come soon.”

    Historically marginalized groups such as Black students take on more debt than white students and are more likely to default on their loans.

    Recent Ph.D. graduates and postdocs already struggle to cover basic living costs. The student debt burden causes them to delay important milestones, such as purchasing property, which stifles the national economy, the ASBMB noted.

    To alleviate these financial burdens and allow the scientific workforce to grow, the ASBMB called for the Education Department to expand public and private service programs similar to the successful National Institutes of Health loan-repayment program. This program aims to counteract “financial pressure by repaying up to $50,000 annually of a researcher’s qualified education debt in return for commitment to engage in NIH mission-relevant research.”

    Neote said: “Education attainment and fulfillment should not come with such an unattainably high price tag.”

    About the American Society for Biochemistry and Molecular Biology (ASBMB): The ASBMB is a nonprofit scientific and educational organization with more than 12,000 members worldwide. Founded in 1906 to advance the science of biochemistry and molecular biology, the society publishes three peer-reviewed journals, advocates for funding of basic research and education, supports science education at all levels, and promotes the diversity of individuals entering the scientific workforce. For more information about the ASBMB, visit www.asbmb.org.

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  • Wells Fargo Innovation Incubator Partnership with Danforth Plant Science Center Announces New Cohort Focused on Climate-Aligned Agriculture

    Wells Fargo Innovation Incubator Partnership with Danforth Plant Science Center Announces New Cohort Focused on Climate-Aligned Agriculture

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    Newswise — ST. LOUIS, MO – July 11, 2023 — The Wells Fargo Innovation Incubator (IN²), a technology incubator and platform funded by the Wells Fargo Foundation and co-administered by the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL), announced today it selected seven startups to participate in the program’s 12th cohort. The cohort consists of sustainable agriculture companies focused on mitigating and adapting to the impacts of climate change on global food systems.   

    “In the face of intensifying challenges in the agriculture industry and our environment, the world urgently needs innovative, sustainable solutions,” said Trish Cozart, IN² program manager and the director of the Innovation and Entrepreneurship Center at NREL. “With projections indicating a global population of 10 billion people by 2050, we must develop methods that not only increase productivity, but do so without causing harm to our planet. IN² is at the forefront of this mission, supporting promising startups that are reimagining the future of food and farming.”

    Each company will receive up to $250,000 in non-dilutive funding for various technical assistance and field trial projects to further refine their technologies and business models. The companies will work alongside world-renowned principal investigators at the Donald Danforth Plant Science Center in St. Louis, Missouri, the world’s largest independent plant science research institute. 

    “IN²’s twelfth cohort highlights some of the best startups in climate-aligned agriculture,” said Elliott Kellner, director of commercial innovation at the Danforth Center. “The selected companies have commercially viable technologies with tremendous potential to deliver environmental, economic, and societal benefits.”

    “As one of the top agricultural production lenders in the U.S., Wells Fargo supports scaling clean technologies,” said Robyn Luhning, Chief Sustainability Officer at Wells Fargo. “Through the Wells Fargo IN² program, these companies receive support to commercialize solutions for some of our customers’ most pressing challenges.” 

    The companies were nominated by members of IN²’s Channel Partner network, consisting of more than 60 business incubators, accelerators, and university programs nationwide. The selected startups underwent an in-depth review by Wells Fargo, NREL, the Danforth Center, and IN²’s expert industry advisory board. The seven companies selected for IN²’s cohort 12 are:

    With the addition of these seven companies, IN²’s total portfolio now includes 72 companies, including 26 sustainable agriculture startups. Since joining the IN² program, portfolio companies have raised more than $1.8 billion in external follow-on funding—equivalent to an average of more than $97 for every $1 awarded by Wells Fargo through IN².

    About the Wells Fargo Innovation Incubator (IN²) The Wells Fargo Innovation Incubator (IN²) is a $50 million technology incubator and platform funded by the Wells Fargo Foundation. Co-administered by and housed at the National Renewable Energy Laboratory (NREL) in Golden, Colorado, IN²’s mission is to speed the path to market for early-stage, clean-technology entrepreneurs. Launched in 2014 with an initial focus on supporting scalable solutions to reduce the energy impact of commercial buildings, IN² has since expanded its focus to advance technologies that address the sustainable production of agriculture and housing affordability. For more information, visit in2ecosystem.com.

    About the Donald Danforth Plant Science Center Founded in 1998, the Donald Danforth Plant Science Center is a not-for-profit research institute with a mission to improve the human condition through plant science. Research, education and outreach aim to have impact at the nexus of food security and the environment, and position the St. Louis region as a world center for plant science. The Center’s work is funded through competitive grants from many sources, including the National Institutes of Health, U.S. Department of Energy, National Science Foundation, the Bill & Melinda Gates Foundation and through the generosity of individual, corporate, and foundation donors. Follow us on Twitter at @DanforthCenter.

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  • U.S. Department of Energy Releases Plan to Ensure Free, Immediate, and Equitable Access to Federally Funded Research

    U.S. Department of Energy Releases Plan to Ensure Free, Immediate, and Equitable Access to Federally Funded Research

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    Newswise — WASHINGTON, D.C. — The U.S. Department of Energy (DOE) today released a plan to ensure the Department’s Federally funded research is more open and accessible to the public, researchers, and journalists as part of a broader effort by the Biden-Harris Administration to make government data more transparent. With 17 National Laboratories and scores of programs that fund university and private research, DOE directly supports thousands of research papers per year, and, when this plan goes into effect, those findings will be available immediately and at no cost.

    “Science and innovation cannot flourish in the dark—they require openness, scrutiny, and reexamination so that we can build on them to create the knowledge and technologies that will change the world,” said U.S. Secretary of Energy Jennifer M. Granholm. “As one of the Federal Government’s leading sponsors of research, DOE is proud and excited to get our data and research out into the public’s hands faster and more efficiently, and we look forward to expanding and accelerating that access by engaging the American public in DOE’s mission.”

    DOE’s public access plan supports the August 2022 White House Office of Science and Technology Policy (OSTP) memo that called for Federal agencies to “make publications and their supporting data resulting from federally funded research publicly accessible without an embargo on their free and public release.” The new plan describes the steps DOE will take to enable equitable access to the unclassified and unrestricted results of its multi-billion dollar annual investments in climate, energy, environment, and basic and applied research and development.

    Since 2014, when DOE released its first plan to grant the public more access to research, the Department has provided free public access to nearly 200,000 articles and accepted manuscripts and has enabled broader access to scientific data through rigorous data management planning requirements.

    Key elements of the new DOE public access plan, as laid out by OSTP, will include elimination of any “embargo” period before the public gains free access to journal articles or final accepted manuscripts resulting from federal funding; immediate access to scientific data displayed in or underlying publications and expanded access to scientific data not displayed in publications; and broad adoption of persistent identifiers (PIDs) for research outputs, organizations, awards and contracts, and people.

    Most requirements and guidance will be in place by the end of 2024 with implementation by the end of 2025. DOE’s model for implementing access to publications and scientific data will be similar to existing practices—for publications, through submissions of accepted manuscripts or open access articles which will be made available through DOE’s public access repository, and for data, through submission of data management and sharing plans to DOE.

    Key changes include the requirement to submit accepted manuscripts or open access journal articles immediately upon publication and an increased focus on immediate and broader sharing of scientific data.

    DOE has played a leading role in the assignment and use of PIDs among Federal research agencies, and the new plan builds on this record and expands DOE’s support of PIDs for research outputs, such as data and software, research and sponsoring organizations, and for researchers themselves. DOE will work internally, and with other agencies, to develop options for PIDs for research and development awards and contracts and will update its public access plan when those details are finalized. 

    The Department engaged with numerous communities in developing its plan and will continue to encourage participation and input from researcher communities, libraries, professional societies, publishers, Federal agency partners, and the public.

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  • Find the latest expert commentary on the recent U.S. Supreme Court decisions here

    Find the latest expert commentary on the recent U.S. Supreme Court decisions here

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    This Thursday, the United States Supreme Court rejected affirmative action at colleges and universities around the nation, declaring that the race-conscious admissions programs at Harvard and the University of North Carolina were unlawful. Now on Friday, the Supreme Court decided to block the Biden administration’s student debt relief program and sided with a Christian web designer in Colorado who refuses to create websites to celebrate same-sex weddings out of religious objections. Despite their limited federal elected power, Conservatives have racked up more huge wins in the great political battles of the early 21st century.

    Newswise is your source for expert commentary. Below is a roundup of recent expert pitches concerning the United States Supreme Court.

    Sociologists Available to Discuss Affirmative Action Ruling in College Admissions

    – American Sociological Association (ASA)

    Law and diversity experts react to Supreme Court’s affirmative action decision

    – Tulane University

    Three important takeaways from SCOTUS decision in Groff v. DeJoy

    – University of Georgia

    SCOTUS decision on race-based admission: experts can comment

    – Indiana University

    U law expert available to comment on Supreme Court decision on affirmative action

    – University of Utah

    Recent SCOTUS decision puts to rest extreme 2020 presidential election claims, confirms state judicial input on states’ election rules

    – University of Georgia

     

     

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    Newswise

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  • Sylvester study identifies ‘marked disparities’ in federal cancer research funding

    Sylvester study identifies ‘marked disparities’ in federal cancer research funding

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    Newswise — MIAMI, FLORIDA (EMBARGOED UNTIL JUNE 8, 2023) – A research team at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine compiled and analyzed statistics from federal cancer research funding sources and found that funds tend to be allocated more heavily toward cancers that occur more often in non-Hispanic white people than in other racial and ethnic groups.

    The study found that funding across cancer sites is not concordant with lethality and that cancers with high incidence among racial/ethnic minorities receive lower funding, but the study’s authors say addressing these inequities could make a difference in cancer research disparities within a short time.

    “The results of this study are immediately actionable,” said Dr. Shria Kumar, a Sylvester gastroenterologist and the senior author of a paper in the June 8 Journal of the National Cancer Institute. “Agencies can evaluate their own recent funding distributions and those for upcoming cycles, then they can prioritize funding for cancers that disproportionately impact minorities to mitigate disparities and reduce cancer burden.”

    The authors analyzed federal funding data to determine correlations between funding directed to cancer incidence and funding aimed at cancer mortality. They focused on National Cancer Institute funding for the 19 most common cancers, considering their respective “public health burdens,” a term that includes the incidence rate of the disease, the mortality rate, and person-years of life lost.

    Although previous studies of funding distribution have evaluated these three factors separately, the Sylvester team evaluated funding using a validated measure – funding-to-lethality (FTL) scores – that incorporates all three metrics and provides a composite, objective perspective on disease burden.

    “We were very surprised that correlation was stronger for incidence than mortality. It shows how complex and multifaceted funding allocation is, but it really underlines the need to look at it objectively, as we did here, and use it as a tool to mitigate cancer disparities, a common goal,” Kumar said.

    Breast and prostate cancer had the highest and second-highest FTL scores, while esophagus and stomach cancer ranked 18th and 19th. Kumar and colleagues noted that breast cancer research received approximately 50 times more funding than stomach cancer in 2018, even though estimated breast cancer deaths were only four times those of stomach cancer deaths.

    The authors also cited previously published statistics showing that cancers more frequently affecting non-Hispanic white people – such as breast cancer, leukemia and lymphoma – receive more funding than cancers with high incidence rates among racial and ethnic minorities – such as stomach, uterine and liver cancers.

    “In my research and in clinical practice, disparities in cancer are an unfortunate but well-known entity. I’m a gastroenterologist, and disparities are of paramount concern in my areas of expertise – stomach and colorectal cancer,” Kumar said. “Racial and ethnic disparities are well documented across the spectrum of cancer types, and this is of utmost importance. The White House’s Cancer Moonshot initiative has a focus on mitigating cancer disparities, and the NCI is very attuned to the impact that disparities have on our quest to improve cancer burden.”

    Specifics from the study:

    • There was a stronger correlation between FTL scores and race/ethnicity-specific cancer incidence, rather than mortality.
    • There was strong correlation between a cancer’s incidence among non-Hispanic white people and its FTL score, but this was not the case for other racial/ethnic groups, where there was only a weak to moderate correlation.
    • There was a moderate to strong correlation between a cancer’s mortality among non-Hispanic white people and its FTL score, but there was only a weak correlation for all other racial/ethnic groups.

    For the study, Kumar and her team obtained data from the NCI’s Surveillance, Epidemiology and End Results (SEER) database, the United States Cancer Statistics (USCS) database, and Funding Statistics between 2014 and 2018. For each year, they identified the incidence rate and mortality rate – both overall and by race/ethnicity – per 100,000 people for the 19 most common cancer sites, as well as NCI funding for each cancer.

    “Despite initiatives to bolster cancer research funding and to mitigate disparities in cancer outcomes, there are marked disparities in federally funded cancer research that do not correlate with lethality,” the authors said. “Our paper identifies discrepancies in funding by demographic groups and highlights the need to ensure that federal funds are equitably distributed. This is especially important given the discrepancies in cancer outcomes for minorities, particularly in the more underfunded cancers.”

    Additional authors: Dr. Shida Haghighat is the study’s first and corresponding author. Co-authors include Dr. Chunsu Jiang, Dr. Wael El-Rifai, Alexander Zaika, and Dr. David S. Goldberg. All authors are affiliated with the University of Miami Miller School of Medicine or Sylvester Comprehensive Cancer Center and the University of Miami Health System.

    Funding: Dr. Haghighat is supported by a National Institutes of Health training grant, T32 DK 116678-05.

    Disclosures: The authors declare no personal, professional or financial conflicts of interest.

    Journal: Journal of the National Cancer Institute: Urgent Need to Mitigate Disparities in Federal Funding for Cancer Research.

    DOI: https://doi.org/10.1093/jnci/djad097

    # # #

    PHOTO CAPTION/CREDIT:

    “Racial and ethnic disparities are well documented across the spectrum of cancer types, and this is of utmost importance,” said Dr. Shria Kumar. “The White House’s Cancer Moonshot initiative has a focus on mitigating cancer disparities, and the NCI is very attuned to the impact that disparities have on our quest to improve cancer burden.” Photo by Sylvester

    # # #

    MEDIA CONTACT:
    Sandy Van
    [email protected]
    808.206.4576

     

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  • Debt ceiling blues. Find political experts on the debt negotiations and the presidential bids in the Politics channel

    Debt ceiling blues. Find political experts on the debt negotiations and the presidential bids in the Politics channel

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    The House is on track Wednesday afternoon to begin considering a bipartisan plan to suspend the nation’s debt ceiling and limit spending, with the nation facing the risk of default if the debt ceiling is not raised by June 1st. The two parties remain deeply divided about how to rein in the federal deficit, with Democrats arguing wealthy Americans and businesses should pay more taxes while Republicans want spending cuts.

    More contenders enter the Republican presidential nominees’ list with Gov. DeSantis and Sen. Tom Scott declaring their bids to run. Do they have enough support to take on the front-runner, former President Donald Trump?

    Below are some of the latest expert pitches posted in the Politics channel.

    DeSantis to launch 2024 presidential campaign on Twitter, expert discusses implications for democracy

    -Virginia Tech

    GW Experts on Ron DeSantis Presidential Campaign Launch

    -George Washington University

    University of West Florida Expert Available to Interview on the Debt Ceiling

    -University of West Florida

    University of West Florida Expert Available to Discuss Gov. Ron DeSantis’ Looming Presidential Campaign

    -University of West Florida

    University at Albany Experts Available to Discuss U.S. Debt Ceiling Crisis

    -University at Albany, State University of New York

    GW Experts on Tim Scott 2024 Presidential Campaign

    -George Washington University

    Social media expert discusses consequences of changes for TikTok, Twitter

    -Virginia Tech

    University of West Florida professor available to interview about Gov. DeSantis’ potential run for President

    -University of West Florida

    Media Availability: Experts to Comment on New Hampshire’s First-in-the-Nation Primary Status

    -University of New Hampshire

    Looming debt ceiling deadline: Expert says economic impact could be significant if deal is not reached by June 1

    -Virginia Tech

    After Title 42: Limited Access to Asylum, Increased Discrimination, Rapid Deportation, predicts SMU Expert

    -Southern Methodist University

    Politics Experts in the Expert Directory 

    Yphtach Lelkes, PhD
    Associate Professor of Communication at the University of Pennsylvania, Annenberg School for Communication

    Yphtach (Yph) Lelkes’s interests lie at the intersection of political communication, public opinion, and political psychology.

    Jennifer   Chudy, PhD

    Jennifer Chudy, PhD
    Knafel Assistant Professor of Social Sciences; Assistant Professor of Political Science at Wellesley College

    Dr. Chudy focuses on White racial attitudes generally and the attitude of racial sympathy – defined as White distress over Black suffering – specifically.

    Adam   Cayton, Ph.D.

    Adam Cayton, PhD
    Associate Professor, Government Department at the University of West Florida

    Dr. Adam Cayton conducts research on representation in Congress, legislative institutions, campaign effects, institutional change, and other topics.

    Megan  Goldberg, Ph.D.

     Megan Goldberg, PhD
    Assistant Professor of American Politics at Cornell College

    Her work examines the dynamics of state politics in an increasingly nationalized context, studies how governors and state parties shift their rhetoric and ideologies towards elections, and how often governors use national politics to frame issues.

    Adam   Cayton, Ph.D.

    Neil O’Brian, PhD
    Assistant Professor of Political Science at the University of Oregon

    Neil can comment on public opinion and political participation in Oregon’s congressional and statewide races as well as national politics. His research agenda and expertise also include the partisan politics of abortion in the United States.

     

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  • Nebraska team explores ways to expand Holocaust education

    Nebraska team explores ways to expand Holocaust education

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    BYLINE: Deann Gayman | University Communication and Marketing

    Newswise — On Holocaust Remembrance Day, a large group of University of Nebraska–Lincoln undergraduates stood quietly and reflected near the Nebraska Holocaust Memorial in Wyuka Cemetery.

    Following a talk from instructor Gerald Steinacher, Rawley Professor of History, the students walked along the Sea of Stones representing the 11 million murdered during the Holocaust, read the names of victims with Nebraska relatives on the bricks among them, and took in the information from the Wall of Remembrance. Some walked the path through the tree-lined Butterfly Garden, placed in memory of the 1.5 million children who were systematically killed by the Nazis.

    Maggie Nielsen, a double major in German and advertising and public relations, said the experience at the memorial was moving, especially because she is Jewish.

    “It was really nice to see the responsiveness to the memorial,” she said. “It seems random to have such a thing in Nebraska, when you think about the grand scheme of things, but you realize, looking around and reading the names, there’s good reason for it to be here, and it was touching to see my non-Jewish classmates take part in something so meaningful. It was beautiful to witness.”

    Steinacher asked the students afterward to write a reflection as they sat surrounded by the Sea of Stones and looking up to the gleaming metal, concrete and photos that formed the Star of Remembrance.

    Reflections following experiences like this one, and interactions with second-generation survivors, are a key component to the class, History of the Holocaust, as Steinacher has centered the course design on helping students understand and more fully grasp the atrocities as well as what led up to them.

    And, with the passage of time, that’s becoming harder, he said.

    “We used to be able to bring survivors to class to talk directly with our students and share their stories,” Steinacher said. “That always had an impact by bridging the distance of space and time, but most survivors have now passed away, or are not able to travel because of age or poor health. We’re crossing the bridge between contemporary history — when we can remember things because we lived them — and history, when those who experienced it are no longer here.”

    That fact, as well as rising antisemitism and Holocaust distortion, makes this class, and others like it, all the more important. For the last five years, Ari Kohen, Schlesinger Professor of political science and director of the Harris Center for Judaic Studies, and a team of Nebraska scholars including Steinacher, have been gathering data on best practices in Holocaust education, with the aim of making courses more meaningful and impactful for students.

    “In general, there is a knowledge problem,” Kohen said. “We’ve seen data that tells us students are not learning about the Holocaust. But more than that, we’re seeing a caring problem. The timeliness of this project matters because there has been a dramatic resurgence in antisemitic incidences all over the country.”

    In 2020, Kohen and Steinacher published the first article based in the findings of the pilot study. That article caught the attention of the Conference on Jewish Material Claims against Germany, based in New York, which has funded the research for four years.

    With the funding, Kohen said they will be able to continue the mixed methods approach to learning how to teach about the history of the Holocaust in a way that resonates with students. Students who take the class and opt-in to participate are asked to complete a pre- and post-survey, take part in an interview about the course, and have their written reflections from the class coded and incorporated into the study. With the grant, Kohen said they’ve been able to add research strength to the team, including the addition of expertise from Nebraska’s Methodology and Evaluation Research Core. Kohen also hopes to incorporate alumni of the course into the surveys.

    Most of the findings have lined up with the researchers’ hypotheses — that personal narratives and experiences are the most impactful, which can be realized with book choices and adding experiential learning into the syllabus.

    “Overwhelmingly, students have mentioned the book ‘The Sunflower’ (by Simon Wiesenthal), as something that made them think differently,” Kohen said. “There are excellent historical texts on this time period, but they don’t seem to land the same way — it doesn’t stick with them.

    “We’ve found there is something really impactful about the field trips, where students have visited a synagogue or the Holocaust Memorial or have had the opportunity to meet and speak with people who are Jewish. It seems like common sense, and things we’ve known as educators, but having quantitative information that shows these things work could help educators design more impactful courses everywhere.”

    The funding will help cover costs to host a conference for educators in the future to talk about the findings and how to translate these best practices to both high school and undergraduate college courses. Kohen expects the team to welcome educators for these conferences in the final two years of the grant.

    For students like Nielsen, the assigned readings, field trips, reflections and hearing personal stories have helped her delve much deeper into her understanding of the Holocaust.

    “With my background in German, and being Jewish, I had preconceptions and notions that I knew everything about the Holocaust, but this class has challenged those notions and made me rethink how I approach this era,” Nielsen said. “We read the book ‘Ordinary Men,’ which was about people who weren’t targeted, but were still affected because they were forced to become perpetrators. I had always assumed that they were willing, joyful participants, but I’ve realized many were doing what they thought they had to do to not become another target.”

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    University of Nebraska-Lincoln

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  • Immigration experts on Title 42, analysis of immigration policies, and other migrant news in the Immigration Channel

    Immigration experts on Title 42, analysis of immigration policies, and other migrant news in the Immigration Channel

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    Title 42, the United States pandemic rule that had been used to immediately deport hundreds of thousands of migrants who crossed the border illegally over the last three years, has expired. Those migrants will have the opportunity to apply for asylum. President Biden’s new rules to replace Title 42 are facing legal challenges. The US Homeland Security Department announced a rule to make it extremely difficult for anyone who travels through another country, like Mexico, to qualify for asylum. Border crossings have already risen sharply, as many migrants attempted to cross before the measure expired on Thursday night. Some have said they worry about tighter controls and uncertainty ahead. Immigration is once again a major focus of the media as we examine the humanitarian, political, and public health issues migrants must face. 

    Below are some of the latest headlines in the Immigration channel on Newswise.

    Expert Commentary

    Experts Available on Ending of Title 42

    George Washington University Experts on End of Title 42

    ‘No one wins when immigrants cannot readily access healthcare’

    URI professor discusses worsening child labor in the United States

    Biden ‘between a rock and a hard place’ on immigration

    University of Notre Dame Expert Available to Comment on House Bill Regarding Immigration Legislation, Border Safety and Security Act

    American University Experts Available to Discuss President Biden’s Visit to U.S.-Mexico Border

    Title 42 termination ‘overdue’, not ‘effective’ to manage migration

    Research and Features

    Study: Survey Methodology Should Be Calibrated to Account for Negative Attitudes About Immigrants and Asylum-Seekers

    A study analyses racial discrimination in job recruitment in Europe

    DACA has not had a negative impact on the U.S. job market

    ASBMB cautions against drastic immigration fee increases

    Study compares NGO communication around migration

    Collaboration, support structures needed to address ‘polycrisis’ in the Americas

    TTUHSC El Paso Faculty Teach Students While Caring for Migrants

    Immigrants Report Declining Alcohol Use during First Two Years after Arriving in U.S.

    How asylum seeker credibility is assessed by authorities

    Speeding up and simplifying immigration claims urgently needed to help with dire situation for migrants experiencing homelessness

    Training Individuals to Work in their Communities to Reduce Health Disparities

    ‘Regulation by reputation’: Rating program can help combat migrant abuse in the Gulf

    Migration of academics: Economic development does not necessarily lead to brain drain

    How has the COVID-19 pandemic affected immigration?

    Immigrants with Darker Skin Tones Perceive More Discrimination

     

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    Newswise

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  • Gun Violence: Can Research Help?

    Gun Violence: Can Research Help?

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    Newswise — The problem of gun violence in America can at times seem utterly intractable.

    The horrific frequency of mass shootings (almost 300 in the first six months of 2022, according to the Gun Violence Archive), the tragic daily toll of firearm-related deaths (124 per day on average, according to the CDC), and the inability of politicians to implement effective gun control measures have had devastating personal consequences for individuals and families and pose a significant public health challenge for the nation.

    The CDC reports that firearm-related injuries rank among the five leading causes of death for people ages 1 to 44 and are now the leading cause of death for children and adolescents, killing more people ages 1 to 19 than car accidents, drug overdoses, or cancer.

    But for epidemiologist and gun violence expert Charles Branas, PhD, the Gelman Professor of Epidemiology and chair of the Department of Epidemiology in the Mailman School of Public Health, the scope and recalcitrance of the problem only heighten the urgency of answering one basic question: “What do you do about it?”

    Toward that end, in 2020 Dr. Branas helped launch the Columbia Scientific Union for the Reduction of Gun Violence, or SURGE, a coalition of faculty, students, and alumni from across the university dedicated to finding creative scientific solutions to gun violence.

    The need for such interventions is especially pressing given the difficulty of enacting gun control at the state and national levels, despite research by Dr. Branas and others showing that stricter gun control laws do in fact reduce gun violence. (The bipartisan gun safety legislation passed by Congress in June supports some existing evidence-based measures, but in limited fashion.)

    Efforts to find solutions have been hindered by a lack of government funding for scientific research into gun violence. Federal funding dried up in 1996 after Congress passed the Dickey Amendment, which barred the CDC, and later the NIH, from spending money to promote gun control and dissuaded many young scientists from pursuing careers in gun violence research.

    Recently, however, SURGE and other groups persuaded Congress to renew federal funding. And Dr. Branas hopes that fresh grants from the CDC and the NIH, coupled with opportunities for networking and collaboration provided by SURGE, will encourage a new generation of researchers to develop innovative, evidence-based interventions to prevent gun violence. 

    Dr. Branas sees signs that this is already happening.

    Junior faculty, including Ashley Blanchard, MD, a pediatric emergency physician at VP&S, are investigating novel interventions with the support of fellow SURGE members. And the coalition is helping senior faculty like Dr. Branas and Paul Appelbaum, MD, the Elizabeth K. Dollard Professor of Psychiatry, Medicine and Law, engage with like-minded colleagues from a variety of disciplines. Other SURGE members are from Columbia’s schools of law, nursing, and social work and from Teachers College and Barnard College.

    “I remember walking into the room during our first meeting and just being in awe that there was this larger campus consortium of people interested in doing this type of work,” says Dr. Blanchard, assistant professor of pediatrics (in emergency medicine). “As a junior investigator, I can’t navigate the path to a firearm-related research career without having that mentorship. Having that room, and those groups of people, has really been incredible.”

    DEEP ROOTS

    If SURGE represents a new path to novel solutions to gun violence, it builds on decades of work by VP&S physicians. SURGE member Danielle Laraque-Arena, MD, a pediatrician and professor of clinical epidemiology and pediatrics at the Mailman School and VP&S, helped pioneer place-based gun violence interventions while working at Harlem Hospital from 1986 to 2000, a period that coincided with a national spike in gun violence.

    During that time, Dr. Laraque-Arena and Barbara Barlow, MD, then chief of pediatric surgery at Harlem Hospital, partnered with city agencies and community members to reduce injury rates among children and adolescents in central Harlem.

    Data collected through the Northern Manhattan Injury Surveillance System, a population-based survey developed by the Mailman School to tally severe injuries, indicated that adolescents represented 89% of gun-related deaths. Many of the deaths involved unintentional firearm injuries or individuals caught in crossfire, and the vast majority of fatalities occurred before hospitalization, which suggested that only prevention could significantly reduce firearm fatalities among young people in the area. 

    Dr. Laraque-Arena and her colleagues focused on implementing programs designed to create safe spaces and activities for children and adolescents, including several locations that involved rehabilitating and greening public spaces such as parks and playgrounds. The goal was to reduce the risk of intentional and unintentional injuries alike; an analysis showed that such broad-based, environment-oriented projects did significantly reduce firearm injuries.

    Decades later, Dr. Branas tested the power of place-based interventions through citywide experiments conducted in Philadelphia, Detroit, and New Orleans. Among other things, he and his colleagues showed that rehabilitating abandoned buildings and vacant lots, which function as storage lockers for illegal firearms, can reduce gun violence by as much as 39%.

    Dr. Branas is in talks with the parks department and other city agencies to bring similar programs to New York City. Together with SURGE member Sonali Rajan, PhD, an associate professor of health education at Teachers College, Dr. Branas leads a nationwide case-control study of firearm violence prevention tactics and policies in K-12 schools. The study, which is funded by the NIH, will examine 650 schools, comparing the safety measures (metal detectors, active shooter drills, armed school personnel) in place at schools that have experienced shootings with those that have not.

    RIGOROUS SCIENTIFIC APPROACH

    Dr. Appelbaum, who has for many years explored the relationship among mental health, gun violence, and gun policy, and Dr. Blanchard bring a similarly rigorous scientific approach to understanding—and preventing—gun violence.

    In a series of studies examining the relationships among gun ownership, gun violence, and mental illness, Dr. Appelbaum has debunked the notion, often floated by politicians in the wake of mass shootings, that such events can be prevented by addressing serious mental illness.

    “As human beings, we have a natural inclination when we see an act that is incomprehensible to assume that the person who did it must be, in lay terms, crazy,” Dr. Appelbaum says. The data suggest that most of those who commit these acts are not mentally ill. “They’re angry, they’re isolated, they’re frustrated, but they are not suffering from psychosis or other severe mental disorders.”

    Dr. Appelbaum points out that the situation is different for suicide. Depression, substance use, and other mental disorders are strong risk factors for self-harm. As a result, efforts to identify and treat people suffering from such disorders can indeed prevent suicides if done effectively.

    Nonetheless, he says, the most effective way to prevent gun violence, whether directed at others or at oneself, is to limit access to firearms.

    REDUCING ACCESS

    Measures aimed at keeping guns out of the hands of high-risk groups include red flag laws that allow the authorities to temporarily confiscate firearms from individuals who represent a threat to themselves or others; safe storage options, such as gun safes and trigger locks; and child access prevention laws that penalize adults for failing to store firearms safely and allowing children access to them.

    Such measures have been shown to reduce firearm injuries and deaths and could play a particularly important role in preventing suicides. Studies show that most people who attempt suicide do so on impulse, moving from decision to action in less than an hour.

    “There’s good evidence to show that especially in adolescents, the transition from contemplating suicide to action is very short-lived and transient and therefore utilizes whatever means are easily available,” Dr. Blanchard says. 

    The extraordinary lethality of guns means that someone who decides to commit suicide and has access to a firearm is much more likely to succeed than someone who does not. Research indicates that acts of suicide involving a firearm are fatal 90% of the time, compared with 13.5% for self-poisoning.

    “The gun doesn’t give you a second chance,” says Dr. Laraque-Arena.

    As a result, taking firearms out of the equation immediately reduces the likelihood that a suicide attempt will succeed. In keeping with that logic, Dr. Blanchard is conducting a pilot feasibility study of a tablet-based tool called Lock and Protect intended to increase safe storage or removal of guns and other lethal means by parents whose adolescents are at increased risk of suicide.

    The tool is being studied in the pediatric emergency department at NewYork-Presbyterian’s Morgan Stanley Children’s Hospital, where Dr. Blanchard and her colleagues often see patients who engage in predictors of suicide such as suicidal ideation and self-harm. The primary goal of the study, which involves experts from the departments of emergency medicine and psychiatry and the Irving Institute for Clinical and Translational Research’s Implementation Science Initiative, is to determine the feasibility of implementing the tool and expanding a trial for a larger emergency department population.

    Patients and their parents enroll in the study together. The tool evaluates suicide risk using questionnaires such as the Columbia Suicide Severity Rating Scale and guides parents through the process of identifying the lethal means in their homes (guns, medications, ligatures) and understanding how they can best keep their children safe.

    The tool was designed to take into consideration factors such as the cost of safe storage and the values of parents, including those who feel strongly about gun ownership. At tool completion, a safety plan is provided to parents to implement at home. Dr. Blanchard and her team follow up with parents at two weeks and with patients and parents at four weeks, with the long-term objective of understanding if the tool helps change home storage of guns and other lethal means.

    Lock and Protect is precisely the kind of innovative gun violence intervention that Dr. Branas hoped SURGE would produce, and he is certain that more will be developed as the coalition continues to grow.

    “We are two years into this,” he says. “We’ve done quite a bit, but we’re still building.”

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    Columbia University College of Physicians & Surgeons

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