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  • Japan was already grappling with isolation and loneliness. The pandemic made it worse | CNN

    Japan was already grappling with isolation and loneliness. The pandemic made it worse | CNN

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    Tokyo
    CNN
     — 

    Across Japan, nearly 1.5 million people have withdrawn from society, leading reclusive lives largely confined within the walls of their home, according to a new government survey.

    These are Japan’s hikikomori, or shut-ins, defined by the government as people who have been isolated for at least six months. Some only go out to buy groceries or for occasional activities, while others don’t even leave their bedrooms.

    The phrase was coined as early as the 1980s, and authorities have expressed increasing concern about the issue for the past decade – but Covid-19 has made things worse, according to a survey conducted last November by the government’s Children and Families Agency.

    The nationwide survey found that among 12,249 respondents, roughly 2% of people aged 15 to 64 identified as hikikomori, with a slight increase among those aged 15 to 39. With that percentage applied to Japan’s total population, there are an estimated 1.46 million social recluses in the country, according to a spokesperson from the agency.

    Common reasons cited for social isolation were pregnancy, job loss, illness, retirement and having poor interpersonal relationships – but a top reason was Covid-19, with more than a fifth of respondents citing the pandemic as a significant factor in their reclusive lifestyle.

    No further details were given about the impact of Covid-19 on respondents.

    Japan, like many countries in East Asia, maintained stringent pandemic restrictions well into 2022 even as other places embraced “living with Covid.” It only reopened its borders to overseas visitors last October, ending one of the world’s strictest border controls, more than two years after the pandemic began.

    But the toll of the last few years continues to be deeply felt.

    “Due to Covid-19, opportunities for contact with other people have decreased,” said a separate paper published February in Japan’s National Diet Library.

    It added that the pandemic could have worsened existing social problems like loneliness, isolation and financial hardship, pointing to a rise in reported suicides, and child and domestic abuse.

    Experts have previously told CNN that hikikomori is often thought to stem from psychological issues such as depression and anxiety, though societal factors play a role too, such as Japan’s patriarchal norms and demanding work culture.

    But hikikomori had been around long before the pandemic, tied to Japan’s other looming problem: its population crisis.

    Japan’s population has been in steady decline since its economic boom of the 1980s, with the fertility rate and annual number of births falling to new record lows several years in a row.

    All the while, the elderly population is swelling as people age out of the workforce and into retirement, spelling trouble for an already stagnant economy. Things are so dire the prime minister warned this year that the country was “on the brink of not being able to maintain social functions.”

    For families with hikikomori members, this poses a double challenge, dubbed the “8050 problem” – referring to social recluses in their 50s who rely on parents in their 80s.

    Authorities have cited other factors, too, like the rising number of single adults as the appeal of dating and marriage wane, and weakening real-life ties as people move their communities online.

    In 2018, Japan’s Ministry of Health, Labor and Welfare established a hikikomori regional support body to help those impacted by the phenomenon.

    “We believe that it is important to restore ties with society while providing detailed support for those who have withdrawn by attending to their individual situations,” said Takumi Nemoto, then-head of the ministry, in 2019.

    He added that local and national authorities had launched various services such as consultations and home visits to those affected by hikikomori, housing support for middle-aged and older people, and other community outreach efforts for “households that have difficulty reporting an SOS on their own.”

    But these efforts were dwarfed by the challenges brought during the pandemic, prompting the government to carry out nationwide surveys on loneliness starting 2021, and to release a more intensive plan of countermeasures in December 2022.

    Some measures include pushing public awareness and suicide prevention campaigns through social media; assigning more school counselors and social workers; and continuing a 24/7 phone consultation service for those with “weak social ties.”

    There are also programs geared toward single-parent households such as meal plans for their children, housing loans, and planning services for those going through divorce.

    Though the pandemic may have caused greater loneliness in society, it may also have simply shed light on long-existing problems that usually go overlooked, said the government in the plan.

    “As the number of single-person households and elderly single-person households is expected to increase in the future, there is concern that the problem of loneliness and isolation will become more serious,” it said.

    “Therefore, even if the spread of Covid-19 is brought under control in the future, it will be necessary for the government to … deal with the problems of loneliness and isolation inherent in Japanese society.”

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  • Indiana and Idaho enact bans on gender-affirming care for transgender youth | CNN Politics

    Indiana and Idaho enact bans on gender-affirming care for transgender youth | CNN Politics

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    CNN
     — 

    Indiana Republican Gov. Eric Holcomb signed a bill Wednesday to ban gender affirming care for minors in the state, following a growing trend of GOP-led states restricting transgender youth’s access to such treatments after Idaho enacted similar legislation earlier in the week.

    “Permanent gender-changing surgeries with lifelong impacts and medically prescribed preparation for such a transition should occur as an adult, not as a minor,” Holcomb said in a statement upon signing Senate Bill 480 into law.

    The legislation, which takes effect July 1, states that physicians or practitioners who provide minors with such care, including puberty blocking medication, hormone therapy and surgery intended to help transition genders, will be subject to discipline by their regulatory board.

    Transgender youths’ access to gender-affirming care – medically necessary, evidence-based care that uses a multidisciplinary approach to help a person transition from the gender they were designated at birth to the gender by which they want to be known – has become a flashpoint in red states across the country.

    Some Republicans have expressed concern over long-term outcomes and whether children should be able to make such consequential decisions, even with parental consent. But major medical associations say that gender-affirming care is clinically appropriate for children and adults with gender dysphoria – a psychological distress that may result when a person’s gender identity and sex assigned at birth do not align, according to the American Psychiatric Association.

    Indiana’s new legislation was met with immediate backlash by LGBTQ advocates.

    The American Civil Liberties Union and local ACLU of Indiana sued the state Wednesday on behalf of four transgender youth and their families, as well as a doctor and healthcare clinic, alleging the new law violates their constitutional rights.

    “Gender-affirming care is life-saving care for our clients,” Ken Falk, legal director of the ACLU of Indiana, said in a statement. “No child should be cut off from the medical care they need or denied their fundamental right to be themselves — but this law would do both.”

    Holcomb’s signing of SB 480 came a day after Idaho Republican Gov. Brad Little enacted similar legislation.

    Under the Idaho law, which takes effect on January 1, 2024, physicians or practitioners who provide gender affirming care, including puberty blocking medications as well as surgeries, could face a $5,000 fine and a felony charge.

    “In signing this bill, I recognize our society plays a role in protecting minors from surgeries or treatments that can irreversibly damage their healthy bodies. However, as policymakers we should take great caution whenever we consider allowing the government to interfere with loving parents and their decisions about what is best for their children,” Little said in a statement to lawmakers.

    Following Little’s signing of the bill, the ACLU of Idaho said it planned to challenge the law.

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  • Video: A pause on AI development, why it’s the worst time to buy a car in decades on CNN Nightcap | CNN Business

    Video: A pause on AI development, why it’s the worst time to buy a car in decades on CNN Nightcap | CNN Business

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    The dangers of AI, the worst time to buy a car in decades, and the next Elizabeth Holmes?

    NYU’s Gary Marcus tells “Nightcap’s” Jon Sarlin why he signed an open letter calling for a six-month pause on AI development. Plus, CNN’s Peter Valdes-Dapena explains why car prices may never go back to where they were pre-Covid. And Forbes’ Alexandra Levine details the arrest of Charlie Javice, the 31-year-old fintech founder who sold her company to JPMorgan and now stands accused of fraud. To get the day’s business headlines sent directly to your inbox, sign up for the Nightcap newsletter.

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  • Robert F. Kennedy Jr. files paperwork to run for president as a Democrat | CNN Politics

    Robert F. Kennedy Jr. files paperwork to run for president as a Democrat | CNN Politics

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    CNN
     — 

    Environmental lawyer and anti-vaccine activist Robert F. Kennedy Jr. has filed paperwork with the Federal Election Commission to run for president in 2024 as a Democrat.

    The filing was confirmed Wednesday by his campaign treasurer, John E. Sullivan.

    The 69-year-old is the son of former New York senator, US attorney general and assassinated 1968 presidential candidate Robert F. Kennedy and the nephew of the late President John F. Kennedy.

    Kennedy Jr. is a longtime vaccine skeptic. He has promoted discredited claims linking vaccines and autism and founded the anti-vaccine organization Children’s Health Defense. He has also railed against the coronavirus vaccine and has criticized the federal government’s handling of the pandemic.

    In 2019, three members of his family – his sister Kathleen Kennedy Townsend, brother Joseph P. Kennedy II and niece Maeve Kennedy McKean – forcefully denounced his anti-vaccine views in a Politico Magazine op-ed, arguing that he was “part of a misinformation campaign that’s having heartbreaking – and deadly – consequences.”

    In 2022, Kennedy Jr. invoked Nazi Germany in an anti-vaccine speech at the Lincoln Memorial in Washington, DC. The previous year, Instagram took down his account “for repeatedly sharing debunked claims about the coronavirus or vaccines.”

    Kennedy had tweeted last month that he was considering a presidential run.

    “If it looks like I can raise the money and mobilize enough people to win, I’ll jump in the race,” he said.

    His tweet also pointed supporters to his website: “Let Bobby know you want to see his leadership in the White House,” the site says while asking for donations.

    As an environmental lawyer, Kennedy worked with a group that led the Hudson River cleanup. He also worked for the Natural Resources Defense Council and co-founded an environmental law firm.

    Should he go through with his presidential bid, Kennedy would be the latest in a long line of family members to enter politics.

    His sister Kathleen served as the lieutenant governor of Maryland from 1995 to 2003. His brother Joseph was a congressman from Massachusetts from 1987 to 1999. And more recently, his brother Chris Kennedy was an unsuccessful candidate for governor of Illinois in 2018.

    The last Kennedy to hold elected office was his nephew former Massachusetts Rep. Joe Kennedy III, who lost a Democratic Senate primary in 2020. (He is now the US special envoy for Northern Ireland.) Caroline Kennedy, the daughter of former President Kennedy, is currently the US ambassador to Australia.

    The 2024 Democratic presidential race is only beginning to take shape, with President Joe Biden expected to announce his bid for a second term. Author Marianne Williamson launched a second long-shot campaign for the Democratic presidential nomination last month.

    On the Republican side, former President Donald Trump jump-started the race for the party nomination, announcing his third bid for the White House last year. Former United Nations Ambassador Nikki Haley, former Arkansas Gov. Asa Hutchinson and entrepreneur Vivek Ramaswamy are also in the race, while other well-known contenders, including Florida Gov. Ron DeSantis and former Vice President Mike Pence, are weighing bids of their own.

    This story has been updated with additional information.

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  • Florida Senate passes 6-week abortion ban | CNN Politics

    Florida Senate passes 6-week abortion ban | CNN Politics

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    Washington
    CNN
     — 

    Florida’s state Senate on Monday passed a bill that would ban most abortions in the state after the gestational age of six weeks, or about four weeks of pregnancy.

    The bill’s advance, which still needs to pass the state’s GOP-led House, comes one year after Gov. Ron DeSantis signed a 15-week ban into law. The new legislation likely further burnishes the conservative credentials of DeSantis, a potential 2024 presidential candidate, and it was met with outrage by state Democrats, two of whom were arrested during a protest near the state Capitol Monday night.

    The current bill would impose restrictions on telehealth abortions and medication. It would include exemptions for women facing life-threatening harm while pregnant and victims of rape, incest and human trafficking.

    The bill targets both physicians who perform abortions and those who “actively participate in” them, and should the bill become law, any person who violates it could be charged with a third-degree felony.

    The “Heartbeat Protection Act” passed the Florida Senate in a 26-13 vote.

    A protest over the bill near the state Capitol resulted in the arrests of 11 people who were charged with trespassing after a warning, Tallahassee police said. Florida Democrats said state party Chairwoman Nikki Fried and Florida Senate Minority Leader Lauren Book were among them.

    “As the Democratic leader in the Florida Senate, it’s my job to a lead this incredible group of 11 Democrats, other than myself, to fight against these extreme policies,” Book told CNN on Wednesday. ‘Women will die as a consequence of this piece of policy.”

    Other abortion rights advocates say the Florida bill unfairly seeks to ban abortions before many even know they are pregnant.

    “This bill will unfairly and disproportionately impact people who live in rural communities, people with low incomes, people with disabilities, and people of color,” Kara Gross, the legislative director and senior policy counsel at the American Civil Liberties Union of Florida, said in a statement.

    “Hundreds of thousands of pregnant people will be forced to travel out of state to seek the care they need. Many people will not even know they are pregnant by six weeks, and for those who do, it is unlikely they will be able to schedule the legally required two in-person doctor’s appointments before six weeks of pregnancy,” Gross said.

    The White House has also criticized the pending bill.

    “The President and Vice President believe women should be able to make health care decisions with their doctors and families – free from political interference. They are committed to protecting access to reproductive care, and continue to call on Congress to restore the protections of Roe v. Wade in federal law,” White House press secretary Karine Jean-Pierre said in a statement when the bill was first introduced.

    State Sen. Clay Yarborough, one of the bill’s Republican sponsors, said “unborn children deserve the strongest protections possible under our laws.”

    The legislation underscores the ongoing efforts across the country to restrict access to abortion in a post-Roe world. Other Republican-led states have also pursued six-week abortion bans that have been met with legal challenges.

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  • Democrats optimistic about saving abortion access in Wisconsin after liberal’s state Supreme Court win | CNN Politics

    Democrats optimistic about saving abortion access in Wisconsin after liberal’s state Supreme Court win | CNN Politics

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    CNN
     — 

    The victory of a liberal judge in Tuesday’s Wisconsin Supreme Court election marks a significant political realignment toward the left in a crucial swing state, potentially closing the door on an era of Republican dominance with issues such as abortion rights at stake.

    With liberals now poised to effectively control the seven-judge court, Democrats are newly optimistic about saving abortion access in the state, establishing a firewall against any Republican challenges to the 2024 elections and potentially redoing GOP-drawn state legislative and congressional maps. That combination of issues proved a potent force in a race that attracted massive turnout and spending.

    And as they did in last year’s midterms in some places around the country, Democrats, once again, appear to have capitalized on a broad backlash to the US Supreme Court’s overturning of Roe v. Wade and a base still energized by the specter of another Donald Trump presidency.

    Republican-supported Daniel Kelly lost the technically nonpartisan contest to Democratic-backed Janet Protasiewicz, who will begin a 10-year term this summer, effectively flipping control of the divided bench to liberals. Conservative Justice Patience Roggensack’s retirement opened the seat, triggering a contentious race that attracted national attention – and donor dollars. It was the most expensive state judicial election in the country ever.

    “Anger about Roe hasn’t dissipated. Fear for our democracy remains. Voters are still alarmed by the MAGA extremism of candidates like Dan Kelly. And if this race is an early bellwether – we can safely say that Republicans didn’t learn their lesson in 2022,” said Sarah Dohl, the chief campaigns officer for Indivisible, a progressive advocacy group.

    Wisconsin has emerged as one of the country’s most competitive political fronts, with ground that’s expected to again be hotly contested in next year’s presidential and Senate races. But the state government – outside the governor’s office – has been bossed by Republicans. Since defeating GOP Gov. Scott Walker more than four years ago, Democratic Gov. Tony Evers has vetoed roughly 150 bills and been hamstrung in pursuing large parts of his own agenda. Now, GOP policy gains at the state level – most notably its crushing of public sector labor unions – are in doubt.

    In the years before Trump’s emergence, the Wisconsin GOP ran roughshod over state politics and sought to export its national playbook around the country. Walker entered the 2016 GOP presidential primary as an early favorite, pitching his state as a model for the nation. But like so many others in that year’s Republican field, he never got off the blocks as Trump thundered to the nomination.

    That fall, Trump shattered the Democratic illusion of a “blue wall” in the Upper Midwest, defeating Hillary Clinton by fewer than 25,000 votes in the Wisconsin general election.

    But Trump’s victory also triggered a backlash – and a mini Democratic resurgence at the state level.

    Evers was first elected governor during the 2018 Democratic wave. He won a second term last year. And though Republican Sen. Ron Johnson held his seat in 2022, Trump had lost the state two years earlier by a little more than 20,000 votes. His false allegations of 2020 election fraud infuriated Democrats, along with many swing voters, and ultimately in this year’s Wisconsin Supreme Court race hobbled Kelly, who faced blowback for his role in advising GOP officials in their efforts to hatch a fake electors scheme

    And while the court could find itself ruling on election laws again, abortion may the most immediate battle to reach the justices.

    The state’s high court is expected to decide a lawsuit challenging an 1849 law that bans nearly all abortions, which had been dormant for decades but snapped back into place with last year’s US Supreme Court ruling. Protasiewicz, Wisconsin Democrats and allied groups such as Planned Parenthood, NARAL Pro-Choice America and Emily’s List all worked to frame the race as another referendum on abortion rights.

    “For over a decade, anti-choice ideologues have held their iron grip on Wisconsin’s highest court, leaving voters hungry for change,” NARAL president Mini Timmaraju said in a statement. “Judge Janet’s resounding victory comes as abortion access faces an onslaught of attacks by extremist state courts determined to tear up our rights at every step.”

    Victory for abortion rights activists follows a similar result in neighboring Michigan, which voted last fall to enshrine abortion and other reproductive rights into the state constitution while reelecting Democratic women to its three most powerful executive offices. Those results continued a streak of successes for Democrats who dug in hard on the issue – a political winner in many swing states and legislative districts.

    Kelly, the conservative in Wisconsin, was coy about how he would rule on a slate of potential hot-button cases, but his past writings and work for anti-abortion groups allowed Protasiewicz, who signaled her skepticism about the ban, to attack him on the issue. Her past comments also suggest a new day’s dawning for the labor community and Democrats seeking to upend the state’s skewed legislative maps.

    “Everything from gerrymandering to drop boxes to Act 10 may be revisited to women’s right to choose,” Protasiewicz told Wisconsin Radio Network in February. (Act 10 eliminated collective bargaining for most public sector employees.)

    And with another presidential election on the horizon, her willingness to consider attempts to roll back or reverse restrictive voting laws or regulations could have clear national implications.

    The state’s voter ID laws, put in place by Republicans, are among the strictest in the country. Wisconsin’s high court played a pivotal role in the outcome of the 2020 election, rejecting a Trump lawsuit aimed at invalidating Joe Biden’s victory – but only by a 4-3 margin with one conservative justice siding with the liberals.

    In the event of another challenge like that, Democrats would now only need their allies to hold the line to prevent a similar bid.

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  • Wisconsin voters are deciding control of state Supreme Court in most consequential election of 2023 | CNN Politics

    Wisconsin voters are deciding control of state Supreme Court in most consequential election of 2023 | CNN Politics

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    CNN
     — 

    Wisconsin voters on Tuesday are deciding the outcome of a state Supreme Court race that could be the most consequential election of the year.

    The race between Democratic-backed Milwaukee County Circuit Court Judge Janet Protasiewicz and Republican-backed former state Supreme Court Justice Daniel Kelly could both break a decadelong era of Republican dominance in one of the nation’s most important swing states and prove pivotal in the fight over the future of abortion access. It’s the most expensive state judicial race ever.

    Conservatives currently hold a 4-3 majority on the Wisconsin high court. But the retirement of conservative Justice Patience Roggensack has given liberals an opening to retake control for at least the next two years, and with it fundamentally shift the political landscape in a state that has been ensnared in political conflict for more than a decade. The race could also effectively decide how the court will rule on legal challenges to Wisconsin’s 1849 law banning abortion – which took effect after the US Supreme Court overturned Roe v. Wade last summer.

    Wisconsin is one of 14 states that directly elect their Supreme Court justices, and winners get 10-year terms. The races are nominally nonpartisan, but political parties leave little doubt as to which candidates they support. Spending in this year’s race – which reached $28.8 million as of March 29, according to the Brennan Center – has far surpassed the previous record for spending on a state judicial contest: $15.4 million in a 2004 Illinois race.

    Republican sway in Wisconsin began with Gov. Scott Walker’s election in 2010 – a victory that was followed by the passage of union-busting laws and state legislative districts drawn to effectively ensure GOP majorities, all green-lit by a state Supreme Court where conservatives have held the majority since 2008.

    Walker lost his bid for a third term to Democratic Gov. Tony Evers in 2018. But Evers has been hamstrung by the Republican-led legislature, with the conservative Supreme Court breaking ties on matters such as a 2022 ruling during the once-a-decade redistricting process in favor of using Republican-drawn legislative maps rather than ones submitted by Evers. The decision cemented Republicans’ solid majority in the state legislature.

    Revisiting those maps, which Protasiewicz has criticized, could lead to new state legislative districts that are less favorable to Republicans if she is victorious.

    The court has also shaped Wisconsin elections in other ways. It barred the use of most ballot drop boxes last year and ruled that no one can return a ballot in person on behalf of another voter. The court played a pivotal role in the outcome of the 2020 election in Wisconsin: Justices voted 4-3, with conservative Brian Hagedorn joining the court’s three liberals, to reject former President Donald Trump’s efforts to throw out ballots in Democratic-leaning counties.

    Tuesday’s election will set the stage for the 2024 presidential race, with the court likely to be asked to weigh in again on election rules, including the state’s voter identification law, and potentially sort through another round of legal challenges afterward.

    But the most immediate battle likely to reach the justices as early as this fall is over Wisconsin’s 1849 law that bans abortion in nearly all circumstances.

    Groups on both sides of the abortion divide have poured vast sums into the race and have attempted to mobilize voters ahead of Tuesday’s election.

    Though the two candidates have refused to say how they’d rule on the issue, they’ve left little doubt about their leanings.

    In a debate last month, Protasiewicz said she was “making no promises” on how she would rule. But she also noted her personal support for abortion rights, as well as endorsements from pro-abortion rights groups. And she pointed to Kelly’s endorsement by Wisconsin Right to Life, which opposes abortion rights.

    “If my opponent is elected, I can tell you with 100% certainty, that 1849 abortion ban will stay on the books. I can tell you that,” Protasiewicz said.

    Kelly, who has done legal work for Wisconsin Right to Life, shot back, saying Protasiewicz’s comments were “absolutely not true.”

    “You don’t know what I’m thinking about that abortion ban,” he said. “You have no idea. These things you do not know.”

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  • US health officials aim to ‘transform’ Alzheimer’s disease research with $300 million data platform | CNN

    US health officials aim to ‘transform’ Alzheimer’s disease research with $300 million data platform | CNN

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    CNN
     — 

    The US National Institute on Aging is moving forward with efforts to build a real-world Alzheimer’s disease database as part of its aim to improve, support and conduct more dementia research.

    Last month, the agency, part of the National Institutes of Health, posted a notice of the grant for the six-year database project, setting its earliest start date as April 2024.

    The NIH confirmed Tuesday that plans are underway to fund the Alzheimer’s disease and Alzheimer’s disease-related dementias’ real-world data platform.

    The National Institute on Aging intends to commit $50 million per year, starting in fiscal year 2024, to fund one award.

    The nonprofit Alzheimer’s Association is among those planning to apply for the grant.

    “The newly-announced NIA funding for a large-scale Alzheimer’s disease research database is truly exciting and a very important step forward for our field, and the Alzheimer’s Association will apply for that grant,” Maria C. Carrillo, Alzheimer’s Association chief science officer, said in an email Tuesday.

    “The Association is already leading ALZ-NET, which is a national network of physicians that is collecting data – including measures of cognition, function and safety – for patients treated with new FDA-approved Alzheimer’s treatments,” Carrillo said. “The NIA funding could expand ALZ-NET’s scope to the benefit of all stakeholders.”

    She added that the Alzheimer’s Association believes everyone should have access to treatments, regardless of their registration status.

    The real-world database “aims to transform” the Alzheimer’s disease research enterprise “by serving as a central hub of research access,” the National Institute on Aging said last week in its announcement of a webinar about the project that’s scheduled for April 19.

    According to the announcement, the aim of the data registry is to provide a comprehensive and diverse database that can “improve applicability and generalizability of findings,” be used as a tool for researchers and allow scientific questions to be answered more quickly.

    Last year, the National Institute on Aging convened an exploratory workshop to discuss gaps in real-world data and opportunities to expand real-world data sources for dementia research.

    Alzheimer’s disease, a brain disorder that affect memory and thinking skills, is the most common type of dementia, the NIH says.

    More than 6 million Americans are living with dementia caused by Alzheimer’s disease, according to the Alzheimer’s Association, and the number of people affected is projected to double in the next two decades, rising to 13 million in 2050.

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  • Infertility affects a ‘staggering’ 1 in 6 people worldwide, WHO says | CNN

    Infertility affects a ‘staggering’ 1 in 6 people worldwide, WHO says | CNN

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    CNN
     — 

    An estimated 1 in 6 people globally are affected by infertility, according to a new report from the World Health Organization, which emphasizes that the condition is common.

    Rates of infertility – defined as not being able to conceive after a year of having unprotected sex – are similar across all countries and regions, Monday’s WHO report says.

    “In our analysis, the global prevalence of lifetime infertility was 17.5%, translating into 1 out of every 6 people experiencing it in their lifetime,” Dr. Gitau Mburu, a scientist of fertility research at WHO, said Monday.

    “Lifetime prevalence of infertility does not differ by income classification of countries,” he said. “Lifetime prevalence was 17.8% in high-income countries and 16.5% in low- and middle-income countries, which, again, was not a substantial or significant difference.”

    Yet there are differences in how much people are spending on fertility treatments and how accessible such treatments are, according to the report.

    “People in the poorest countries were found to spend a significantly larger proportion of their income on a single cycle of IVF or on fertility care compared with wealthier countries,” Mburu said, “exemplifying that this is an area with high-level risk of inequality in access to health care.”

    Global public health groups typically call attention to overpopulation as a major public health concern, so the spotlight that the WHO report turns on infertility not only is surprising but is welcome, said Dr. David Keefe, reproductive endocrinologist and infertility specialist at the NYU Langone Fertility Center in New York.

    “That report did not surprise me in terms of the content, because it’s been known for some time that infertility is much more prevalent than anyone wants to think about: Having a child and having a family is kind of a universal dream or aspiration for people from every country, from every region. What surprised me was the World Health Organization coming out in support of it,” said Keefe, who was not involved with the WHO research.

    “It was a welcome acknowledgment of the other foot dropping on the population front,” he said. “The acknowledgment that this is a worldwide problem and that additional attention must be devoted to it in terms of policy and strategy is welcome.”

    The WHO report – described as the “first of its kind in a decade” – includes an analysis of infertility data from 1990 through 2021. The data came from 133 previously published studies on infertility prevalence.

    “The purpose of this analysis was to generate updated data on the global and regional estimates of infertility prevalence by analyzing all available data from different countries, making sure that we take into account different study approaches,” Mburu said.

    Based on that data, the researchers estimate that lifetime prevalence of infertility – representing the proportion of people who have ever experienced infertility in their reproductive life – was 17.5% in 2022.

    The period prevalence of infertility, meaning the proportion of people with infertility at any given point currently or in the past, was found to be 12.6% in 2022.

    Although the data showed some variation in infertility prevalence across regions – with the highest lifetime prevalence at 23.2% in the Western Pacific, compared with the lowest at 10.7% in the Eastern Mediterranean – those regional differences were not either substantial or conclusive based on the data, according to WHO’s report.

    The researchers also did not determine whether global infertility rates have been increasing or decreasing over time.

    “The data which we analyzed for this report was from 1990 to 2021, and during that period, we did not see evidence of increasing rates of infertility. However, the way the data was arranged, it was not really organized to answer that question,” Dr. James Kiarie, head of contraception and fertility care at WHO, said Monday. “We cannot, based on the data we have, say that infertility is increasing or constant – so we must say that probably the jury is still out on that question.”

    Over time, various factors can affect a person’s fertility, and age is one of the most important, said Dr. Emre Seli, chief scientific officer for the maternal and infant health nonprofit March of Dimes. Seli, who is also a professor at Yale School of Medicine and medical director of Yale Fertility Center, was not involved in the new report.

    “Fertility decreases as the age of the female partner increases,” he said.

    “Fertility is really an emotionally taxing issue for those who are affected by it. It is a major source of stress to want to have a child and not be able to,” Seli said. “Most of my patients are women, and they do become affected by this at many levels, and they do suffer from lack of adequate research as well as lack of adequate insurance coverage to undergo the treatments that they need.”

    Infertility, affecting the male or female reproductive system, can be treated with medicine, surgery or assisted reproductive technologies such as in vitro fertilization or IVF, during which an egg and sperm are joined in a lab dish and put into a womb once the fertilized egg becomes an embryo.

    “Infertility is a major and a widespread health issue affecting a staggering 1 in 6 people globally over the duration of their reproductive lives,” Dr. Pascale Allotey, director of the Sexual and Reproductive Health and Research Department at WHO, said Monday.

    Despite that, solutions for the prevention, diagnosis and treatment of infertility remain “underfunded” and “inaccessible” to many patients due to high costs, Allotey said.

    “Infertility is an important public health concern because it can have wide-reaching negative impacts on the lives of the people affected,” she said. “WHO is calling for universal access to affordable high-quality fertility care, improved data to enable infertility to be meaningfully addressed in health policy and programs, and greater efforts to ensure this issue is no longer sidelined in health research and policy.”

    Mburu added that infertility can also have effects on mental health, raising risks of anxiety, depression and intimate partner violence.

    “Our message is that infertility needs to be included as a priority in responding to the needs of populations in different countries,” Mburu said. “This is because people have a right to expect to obtain the highest possible standard of mental, social and physical health as defined by WHO.”

    The new data from WHO reinforces that more people need fertility coverage and access to high-quality care than was previously thought, said Dr. Asima Ahmad, an endocrinologist and fertility expert who serves as chief medical officer and co-founder of Carrot Fertility, a company that helps employers set up fertility benefits. She added that inequities emerge in who has such access to care, such as Black women who tend to experience inequities in access.

    “These inequities, I’m not surprised that they exist on a global level, because we already see the inequities in the United States domestically, with how infertility impacts different populations and how some populations have limited access. And even with the access that they finally get, they, for example, will have a lower rate of success or even a higher rate of miscarriage,” said Ahmad, who was not involved in the new WHO report.

    “A lot of people don’t have access to clinically vetted evidence-based information around what causes infertility, how to recognize it, and then when you do find out that you have it, how to treat it,” she said. “The other, which is one of the biggest barriers that we see, is financial access to fertility. In the United States, a lot of that access comes through the employer providing, for example, fertility benefits, but on a global level, that’s not necessarily the case, and finances tends to be the biggest barrier.”

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  • FDA inspection finds sterilization issues at recalled eye drop manufacturer’s facility | CNN

    FDA inspection finds sterilization issues at recalled eye drop manufacturer’s facility | CNN

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    CNN
     — 

    The manufacturer of eye drops that have been linked to an outbreak of serious bacterial infections in the US, including at least three deaths, did not follow proper protocol to prevent contamination of its products, according to an inspection report published Friday by the US Food and Drug Administration.

    The FDA visited a Global Pharma Healthcare facility in India for an inspection that started in mid-February, 2½ weeks after the company recalled EzriCare Artificial Tears due to possible contamination.

    At the time of the recall, there were 55 reports of adverse events including eye infections, permanent loss of vision and at least one death with a bloodstream infection. As of late last month, 68 infections had been identified in 16 states, according to the US Centers for Disease Control and Prevention. There have been three deaths, eight cases of vision loss and four surgical eye removals reported.

    An 11-day inspection of the Global Pharma facility resulted in 11 observations by the FDA, including a “manufacturing process that lacked assurance of product sterility,” specifically for batches of product that were manufactured between December 2020 and April 2022 and shipped to the US.

    The EzriCare Artificial Tears product, which is manufactured by Global Pharma, is part of an outbreak of infections from bacteria called Pseudomonas aeruginosa.

    This rare drug-resistant bacteria can spread among people who don’t have symptoms – and to people who haven’t used the eye drops, according to the CDC. This type of spread is particularly common in health care settings.

    “The bacteria can spread when one patient carrying the bacteria exposes another patient, or when patients touch common items or when healthcare workers transmit the germs which is why infection control, like hand hygiene, is so important,” the agency told CNN in an email Monday.

    Several cases in the current outbreak have been identified in people who were carrying the bacteria without signs or symptoms of clinical infections, the CDC said. These cases were discovered through screenings at inpatient health care facilities that had clusters of infections.

    The particular strain of the bacteria associated with this outbreak had never before been reported in the US, and related infections have been identified at acute care hospitals, long-term care facilities, emergency departments, urgent care clinics and other outpatient facilities.

    People affected by the outbreak reported using different brands of artificial tears, but EzriCare Artificial Tears was most commonly reported.

    The FDA inspection of the Global Pharma facility is part of an ongoing compliance matter.

    “The FDA’s highest priority is protecting public health – this includes working with manufacturers to quickly remove unsafe drugs from shelves when they are identified,” the agency said in an email Monday. “The FDA continues to monitor this issue and is working with the Centers for Disease Control and Prevention (CDC) and the companies recalling these affected products. We urge consumers to stop using these products which may be harmful to their health.”

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  • Morning after pill brand speeds up retail access, doubles supply per pack | CNN Business

    Morning after pill brand speeds up retail access, doubles supply per pack | CNN Business

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    New York
    CNN
     — 

    One maker said it is responding to high demand for the morning-after pill, after the US Supreme Court last year ended a constitutional right to abortion, by speeding up availability of the emergency contraceptive in retail stores and introducing a new two-count pack.

    Julie launched as a one-step tablet of emergency contraceptive containing Levonorgestrel, the key ingredient in the popular Plan B emergency contraceptive that was approved by FDA in late 1990s without a prescription, at 4,500 Walmart stores nationwide last September.

    The startup experienced a surge in demand for its $42 tablet at launch amid an overall spike in purchases of emergency contraceptive following the US Supreme Court’s ruling overturning Roe v. Wade in on June 24, 2022.

    The FDA-approved morning-after pill can reduce the chance of pregnancy after unprotected sex or failure of another contraceptive method like a condom, and is ideally taken within 72 hours. The pill, which is legal in all 50 US states, works by delaying ovulation or preventing implantation and cannot terminate a pregnancy.

    While the plan from the beginning was always to make the product widely accessible as quickly possible, the Supreme Court’s ruling only compelled the startup to accelerate the timetable for Julie’s nationwide rollout.

    “The Dobbs decision and overturning Roe v. Wade last year rocked everyone’s world, our customers and our retail partners,” said Amanda E/J Morrison, cofounder of Julie. “It lit a fire under us to provide our product to more women and, more importantly, to educate women about emergency contraceptives.”

    In April, just seven months after hitting the market, Julie is now expanding into 5,600 CVS stores and 1,500 Target stores. The brand is also introducing a new 2-count pack of its emergency contraception (which has a three-year expiration period). The two-count pack rolled out at CVS locations over the weekend.

    “With the two-pack, we want to make it easier for women to keep extra emergency contraceptive at home, just like they would with other birth control options like condoms,” said Morrison.

    The price for two-count pack is $70. Morrison said the pill works most effectively the closer it is taken after unprotected sex, ideally within 72 hours.

    Dr. Colleen Denny, a clinical associate professor in the department of obstetrics and gynecology at NYU Grossman School of Medicine, said she saw the upside to a two-count pack of emergency contraception, which she hasn’t seen before from other emergency contraception brands.

    “It generally makes sense for barriers to emergency contraception, prescription and over the counter, to be as low as possible,” said Denny,

    “Emergency contraception is incredibly safe and effective at preventing pregnancy when used in the right time frame,” she said. “Relationships are complicated. There can be situations where there isn’t access to emergency contraception or women might not ask the partner to use it. So being able to have access to one pill and a backup is a great idea.”

    Kelly Cleland, executive director of the American Society for Emergency Contraception, said emergency contraception brands, like Julie, still have to work harder at making the product not only more accessible, but also more affordable.

    “I am in favor of expanding access, but this is a missed opportunity when a generic brand comes into the market with a high price barrier,” Cleland said about Julie’s $70 price for the two-count pack.

    Cleland said a study done last year by the American Society for Emergency Contraception on access to emergency contraception in stores compared price at retail for branded and generic emergency contraception options. The report said some generic options were priced at $6 or less.

    Julie said it set the price for its single pill and two-count pack so it can fund its one-for-one donation program (in which the company donates one box for every box purchased) and to cover business costs tied to packaging and marketing.

    By overturning Roe v. Wade, the Supreme Court revoked the notion that the constitutional right to privacy included an abortion. In Dobbs v. Jackson Women’s Health Organization, the Supreme Court expanded states’ authority to regulate or restrict abortion.

    A total of 26 US states have since implemented new abortion restrictions or all-out bans.

    In the rulings’ immediate aftermath, doctors and prescribers saw a sharp jump in demand for different forms of contraception, including emergency contraception, and longer-lasting forms of birth control. The rush on emergency contraceptives forced some pharmacy chains to impose temporary purchase limits.

    “Every time there is a new development on restrictions to reproduction health care, there’s a run on emergency contraceptive. Our retail partners confirmed this,” said Morrison, adding that news events continue to influence buying patterns for emergency contraceptive.

    “The current political climate has emboldened Julie,” Morrison said. This, according to the company, includes expanding Julie’s available within communities through unexpected places like bars, restaurants and coffee shops.

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  • Sen. Fetterman opens up about ‘downward spiral’ before receiving treatment for depression | CNN Politics

    Sen. Fetterman opens up about ‘downward spiral’ before receiving treatment for depression | CNN Politics

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    CNN
    CNN
     — 

    Pennsylvania Sen. John Fetterman opened up about his struggle with depression during a candid interview with CBS News that was taped during his stay at Walter Reed National Military Medical Center.

    “I had stopped leaving my bed. I had stopped eating. I was dropping weight. I had stopped engaging … most things that I love in my life,” Fetterman told CBS’ Jane Pauley.

    The Pennsylvania Democrat said he had never attempted to harm himself but that he was “indifferent” about his life. “If the doctor said, ‘Gee, you have 18 months to live,’ I’d be like, ‘Yeah. OK, well, that’s how things go,’” he said.

    Fetterman, whose win helped cement Democrats’ 51-49 Senate majority last fall, was discharged last week from Walter Reed, where he had been treated for his depression.

    He had suffered a stroke last year during the days ahead of the primary. When he returned to the campaign trail, Fetterman often struggled to communicate with lingering auditory processing issues, relying on assistance through devices with closed captioning to converse and answer questions.

    The same auditory processing issues impacted him in his early days in the Senate. And when he struggled with substantial weight loss and a loss of appetite, he was diagnosed with clinical depression, and later was admitted to Walter Reed for treatment.

    “I was at a Democratic retreat, and many of my colleagues were coming up to me and asking, ‘Why aren’t you eating?’” Fetterman recalled during the interview.

    But following his discharge from Walter Reed, Fetterman said in a statement, “I want everyone to know that depression is treatable, and treatment works.”

    “This isn’t about politics — right now there are people who are suffering with depression in red counties and blue counties. If you need help, please get help,” he said.

    Fetterman is expected to return to the Senate the week of April 17, but he told CBS that his immediate plans include taking his son “to the restaurant that we were supposed to go (to) during his birthday but couldn’t because I had checked myself in for depression.”

    “And being the kind of dad, the kind of husband, the kind of senator that Pennsylvania truly deserves.”

    Editor’s note: If you or someone you know is struggling with suicidal thoughts or mental health matters, please call the 988 Suicide and Crisis Lifeline, or visit the hotline’s website.

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  • The fatal mauling of 4-year-old forces India to grapple with stray dog problem | CNN

    The fatal mauling of 4-year-old forces India to grapple with stray dog problem | CNN

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    New Delhi
    CNN
     — 

    For nearly a minute, the 4-year-old boy attempts to valiantly escape the hungry pack of stray dogs as they circle around him.

    He tries to run, but one of the animals pulls the boy to the ground. Two more dogs close in, offering the victim little respite.

    The boy, who has not been publicly identified, is dragged by the pack for several feet, writhing in pain as the strays pounce. He strives to wrestle from their grip, but his small and fragile body cannot compete with the aggressors.

    His piercing screams alert his father nearby – but it was too late. The child was declared dead upon arrival at the hospital.

    The brutal attack, captured by a security camera in Hyderabad in February, a sprawling city in the central Indian state of Telangana, has horrified the nation of 1.3 billion and placed focus on an issue that long divided opinion: what to do with India’s vast number of stray dogs?

    The issue is a sensitive one in a country where there is an ingrained cultural respect for animals and an aversion to culling. Most agree stray dogs are an issue, but there is a fierce debate over how best to respond.

    According to the Press Trust of India, there are around 62 million strays in the country, although experts say the real number would be nearly impossible to verify.

    Most of these animals – lovably nicknamed ‘Indie’ dogs – live in harmony with humans. Often, residents of gated communities come together to feed them, some even adopting them as family pets.

    But over the years, bites and killings by stray dogs have put many cities on edge, with politicians, the media, and citizens scrambling to present various solutions.

    Long before the death of the 4-year-old boy in Hyderabad made headlines, local media have run similar tales about India’s “killer dogs” – stories that are then often picked up by international outlets.

    “”Man-eater’ dog terror back in Bihar,” wrote The Telegraph India in a story last month after a series of bites in the northern Indian state.

    It is illegal to kill stray dogs in India. A 2001 law states strays should instead be picked up, neutered, and vaccinated against rabies, before being released.

    But in light of the gruesome attacks, many of which have happened to children, some have attempted to challenge the law.

    In 2016, a campaign to kill stray dogs after a series of bites in the southern state of Kerala gained traction in the local news.

    But animal rights activists were angered, instead urging authorities to offer clemency and find other solutions. The hashtag #BoycottKerala began trending on social media, and the plan was later abolished.

    While the law requires strays to be neutered and vaccinated, experts say there is a lack of strict implementation.

    “Of course we have a stray dog problem,” Anjali Gopalan, managing trustee at the All Creatures Great and Small, a Delhi-based non-profit that cares for animals, said.

    “Not only do we have a stray dog problem, but we also have a problem with rabies in this country. So, steps have to be taken to deal with both.”

    Rabies is a vaccine-preventable disease which can spread to humans if they are bitten or scratched by an infected animal. It is almost always fatal unless a series of jabs can be administered soon after someone is bitten.

    Dogs are the source of the vast majority of human rabies deaths, according to the World Health Organization (WHO) and contribute up to 99% of all rabies transmissions to humans. India is endemic for rabies, the WHO said, accounting for 36% of the world’s rabies deaths.

    A key way to reduce rabies within a stray dog population is to capture and vaccinate as many animals as possible.

    But veterinarian Sarungbam Devi, founder and trustee of Animal India Trust, said India needs to do more.

    “At the time of the sterilization, we vaccinate the dog only once and then they are released. That’s all the vaccination a stray dog gets in his lifetime and that’s not enough,” she said.

    A lack of resources in the country means it is difficult to push government bodies to increase the inoculation of street dogs against the virus, Devi added.

    But when it comes to dog bites, Devi said, education plays the biggest role: “The government hasn’t done anything to increase awareness or educate the masses. We need to educate people, we need to be more vocal and visual about the (anti-bite) programs,” she said.

    “People need to know what to do when a dog bites you, how to you prevent it … I don’t think I have ever seen anything on this anywhere.”

    The Society for the Prevention of Cruelty to Animals (SPCA) recommends avoiding unfamiliar dogs and wild animals, not running when approached by an unknown dog and always supervising children and dogs, among other things, to avoid bites.

    According to the government, more than 6.8 million Indians were bitten by stray dogs in 2020 – and increase from 3.9 million in 2012. And experts say those numbers are likely not the full picture.

    CNN has reached out to the Department of Animal Husbandry and Dairying but has not received a response.

    “The problem is lack of awareness towards how to live around dogs,” Devi said, adding there needs to be an “intense anti-rabies drive and sterilization program everywhere in India.”

    But many Indian cities and states have been successful in bringing down their feral dog population and eradicating rabies.

    In the financial capital Mumbai, as many as 95% of the city’s stray dogs have been sterilized owing to “consistent” implementation of re-vaccination and welfare programs, said Abodh Aras, CEO of the non-profit Welfare of Stray Dogs.

    A robust public health system for post-bite treatment and regular school programs about dog bite and rabies prevention has also contributed, Aras said.

    “There are other places that have success stories. There is Goa that has eliminated rabies, (the state of) Sikkim that has got its state of operations around, and eliminated rabies,” he added. “It needs a combination of government support, will and infrastructure, and animal welfare NGOs working in that area for this model to be successful.”

    But not every city has the resources to implement this model.

    Take for example Noida, a satellite city of more than half a million on the outskirts of Delhi that is a comparatively wealthy place and home to many middle-class families.

    Devi, from the Animal India Trust, said Noida remains “very disorganized,” and her organization is the only non-profit covering the entire city – a colossal and tedious task for a small team, she said.

    Stray dogs caught by authorities in Noida on October 18, 2022.

    Gopalan, from All Creatures Great and Small, points to even more difficult operations in rural India, where electricity is lacking and maintaining cold storage for vaccines is an issue.

    Following the 4-year-old’s death in Hyderabad, officials promised swift action to prevent future tragedies.

    “We have been sterilizing dogs and anti-rabies injections are being given to them,” Greater Hyderabad Municipal Corporation Mayor Vijayalaxmi Gadwal, told local news agency, ANI.

    “So far in Hyderabad we have identified more than 500,000 dogs and sent more than 400,000 dogs for sterilization. We are following every guideline which is being given to us by the Supreme Court. We’re also going to adopt these dogs so that the number of stray dogs will be reduced.”

    That campaign may have an impact locally. But it many fear it is likely only a matter of time before another pack of dogs somewhere in India takes a child’s life.

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  • Meet the judge presiding over Trump’s criminal arraignment | CNN Politics

    Meet the judge presiding over Trump’s criminal arraignment | CNN Politics

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    CNN
     — 

    When Donald Trump enters a New York courtroom on Tuesday, he’ll face a seasoned judge who is no stranger to the former president’s orbit.

    Acting New York Supreme Court Judge Juan Merchan has sentenced Trump’s close confident Allen Weisselberg to prison, presided over the Trump Organization tax fraud trial and overseen former adviser Steve Bannon’s criminal fraud case.

    But Trump’s historic arraignment on Tuesday will perhaps be Merchan’s most high-profile case to date, even after a long career atop the state-level trial court.

    Merchan has been described by observers as a “tough” judge, yet one who is fair, no matter who is before him.

    Here’s what you need to know.

    Trump’s arraignment is likely to be a spectacle with a show of law enforcement and with the former president already fanning the flames on social media with his views on Merchan and his indictment.

    But in the courthouse, Merchan does not stand for disruptions or delays, attorneys who have appeared before him told CNN, and he’s known to maintain control of his courtroom even when his cases draw considerable attention.

    “Judge Merchan was efficient, practical, and listened carefully to what I had to say,” Nicholas Gravante, the attorney who represented Weisselberg in his plea, said via email.

    “He was clear in signaling his judicial inclinations, which helped me tremendously in giving Mr. Weisselberg informed legal advice. Judge Merchan was always well-prepared, accessible, and – most importantly in the Weisselberg matter – a man of his word. He treated me and my colleagues with the utmost respect, both in open court and behind closed doors.”

    Karen Friedman Agnifilo, a private practice attorney who previously worked as the chief assistant district attorney in the Manhattan District Attorney’s Office, supervising cases Merchan presided over, echoed that sentiment.

    “[Merchan] doesn’t let the prosecutors or the defendants create any issues in his courtroom. He doesn’t let a media circus or any other kind of circus happen. I don’t think Donald Trump attacking him and threatening him is going to bode very well for him in the courtroom,” Agnifilo said.

    “The judge is the kind of judge where he will ignore it and not hold it against Donald Trump. He’s not vindictive in any way like that.”

    Merchan showed some of his tough side when Weisselberg was sentenced, telling the former Trump associate that if he had not already promised him a five-month sentence, he would have handed him a “much greater” sentence after having listened to evidence at trial.

    When he presided over Bannon’s criminal fraud case, Merchan chastised the former Trump aide’s new team of attorneys for delaying the case when they asked for more time to review new evidence.

    In addition to the Trump cases, Merchan has also presided over other high-profile cases, including the “soccer mom madam” trial, in which he set a $2 million bond for suburban mom Anna Gristina, who was charged with running a $2,000-an-hour escort service for the wealthy, Bloomberg News reported.

    Merchan also handed a 25-years-to-life sentence to a Senegalese man who raped and murdered his girlfriend.

    Trump attorney Timothy Parlatore said during an interview Friday on CNN that Merchan was “not easy” on him when he tried a case before him, but echoed that the judge likely will be fair.

    “I’ve tried a case in front of him before. He could be tough. I don’t think it’s necessarily going to be something that’s going to change his ability to evaluate the facts and the law in this case,” Parlatore said.

    Merchan, however, is also credited by his peers for having helped create the Manhattan Mental Health Court, which he often presides over and where he has earned a reputation for “compassionate” rulings that give defendants second chances.

    “I watched a colleague of mine try a shooting case where someone got shot, so he’s able to try those very serious violent crimes and then switch,” said Brendan Tracy, a criminal defense attorney who previously served as an assistant district attorney in the Manhattan District Attorney’s Office.

    “Maybe someone who was a serial shoplifter and then charged with grand larceny and is in mental health treatment court because they had mental health issues, he was able to handle the wide range of cases and do them all fairly,” Tracy added.

    Still, Earl Ward, a trial attorney and chair of public defender nonprofit The Bronx Defenders, said that having watched Merchan preside over cases in the Mental Health Court, the judge often sided with prosecutors.

    “He’s fair and his rulings are consistent with the law, but if it’s a close call, his reputation is that he lands on the prosecution’s side,” Ward said.

    Merchan launched his legal career in 1994 when he started off as an assistant district attorney in the trial division in the Manhattan District Attorney’s Office. Several years later, he moved on to the state attorney general’s office, where he worked on cases in Long Island.

    In 2006, New York Mayor Michael Bloomberg, then a Republican, appointed Merchan to Family Court in the Bronx, and Democratic Gov. David Paterson appointed him to the New York State Court of Claims in 2009, the same year he began serving as an acting New York Supreme Court Judge.

    Born in Bogota, Colombia, Merchan emigrated to the United States at the age of 6 and grew up in the New York City neighborhood of Jackson Heights, Queens, according to a New York Times profile of the judge. He was the first in his family to go to college. t

    Merchan initially studied business at Baruch College in New York before he dropped out of school to go work only to return several years later to finish school so that he could get his law degree, the Times reported.

    He eventually received his law degree from Hofstra University.

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  • Abortion foes take aim at ballot initiatives in next phase of post-Dobbs political fights | CNN Politics

    Abortion foes take aim at ballot initiatives in next phase of post-Dobbs political fights | CNN Politics

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    CNN
     — 

    After a string of recent ballot-box victories for abortion rights groups, opponents of the procedure are redoubling their efforts – including, in some places, pushing to make it harder to use citizen-approved ballot measures to guarantee abortion access.

    An anti-abortion coalition in Ohio, for instance, recently unleashed a $5 million ad buy targeting an effort to enshrine abortion rights in the state’s constitution through a ballot initiative – just as the initiative’s organizers won approval to collect signatures to put the question to voters in November. Meanwhile, legislators in Ohio and other states are weighing bills that would make it more difficult to pass citizen-initiated changes to state constitutions.

    The US Supreme Court’s decision to overturn Roe v. Wade last year left abortion laws up to the states, and abortion rights groups quickly scored wins on ballot measures in six of them – including in the battleground state of Michigan, where voters protected abortion access, and in the Republican strongholds of Kansas, Kentucky and Montana, where voters defeated efforts to restrict abortions.

    “What we saw in the midterms last year was a wake-up call,” said Kelsey Pritchard, director of state public affairs for Susan B. Anthony Pro-Life America. She said helping local groups defeat abortion-related ballot measures is one of the top three priorities for the group’s state affairs team.

    Groups on both sides of the abortion divide have poured big sums into an upcoming state Supreme Court race in Wisconsin that has seen record spending and offers a key test of the potency of the abortion issue among voters in a battleground state. Whether a conservative or liberal candidate wins a swing seat Tuesday on the seven-member high court there could determine the fate of abortion rights in the state. A Wisconsin law, enacted in 1849, that bans nearly all abortions is being challenged in court and is likely to land before the state Supreme Court.

    More fights over ballot initiatives on abortion are stirring to life around the country. In addition to Ohio – where a state law banning abortion as early as six weeks into a pregnancy has been put on hold by a judge – abortion rights proponents have begun to push ballot proposals in South Dakota and Missouri. Most abortions are now illegal in those two states.

    And groups in at least more six states are considering citizen initiatives as a way to guarantee or expand access to abortions, said Marsha Donat, capacity building director at The Ballot Initiative Strategy Center, which helps progressive groups advance ballot measures.

    Ohio, however, looms as the next big abortion battleground on the 2023 calendar – with skirmishes already underway in the courts, the state legislature and on the airwaves.

    A state “fetal heartbeat” law that prohibits many abortions as early as six weeks into pregnancy took effect when the US Supreme Court struck down Roe with its decision last June in Dobbs v. Jackson Women’s Health Organization. But the law has been put on hold by a judge in Cincinnati in a case that’s expected to end up before the state’s high court.

    Abortion rights supporters recently won approval to begin collecting signatures to put a measure on the November ballot that would guarantee Ohioans’ access to abortion. If approved by voters, state officials could not prohibit abortion until after fetal viability, the point at which doctors say the fetus can survive outside the womb.

    The initiative says that “every individual has a right to make and carry out one’s own reproductive decisions, including but not limited to decisions” on contraception, fertility treatment, continuing one’s own pregnancy, miscarriage care and abortion.

    It also would bar the state from interfering with an individual’s “voluntary exercise of this right” or that of a “person or entity that assists an individual exercising this right.”

    A conservative group called Protect Women Ohio immediately launched an ad campaign – putting $4 million on the air and $1 million into digital advertising – to cast the amendment as one that would strip parents of their authority to prevent a child from having an abortion or undergoing gender reassignment surgery, although the proposed constitutional amendment makes no mention of transgender care.

    Officials with Protect Women Ohio argue that the initiative’s language is broad enough to be interpreted as extending to gender reassignment surgery, an assertion initiative proponents say is false.

    In the campaign aimed at defeating the amendment, “we’ll make sure they have to own every last word of this radical initiative,” said Aaron Baer, the president of Center for Christian Virtue and a Protect Women Ohio board member, told CNN. “They chose this language for a reason, and we’re not going to let them off the hook.”

    Lauren Blauvelt – who chairs Ohioans for Reproductive Freedom, the group promoting the initiative – said the ad “is completely wrong” and called it an “unfortunate talking point from the other side.”

    “Our amendment … creates the fundamental right that an individual can make their own reproductive health care decisions” and does not touch on other topics, she said.

    But the ad campaign highlights the effort to link abortion to the transgender and parental rights issues currently animating conservative activists.

    Susan B. Anthony’s Pritchard said she believes that her side can win on the issue of limiting abortions but “we believe also that we broaden our coalition and broaden awareness of what these things actually do when we highlight the parental rights issue that is very real.”

    The initiative’s supporters need to collect more than 413,000 signatures from Ohioans by July 5 to qualify for the November ballot. Under current Ohio law, changes to the state’s constitution can be approved via ballot initiative by a simple majority of voters.

    A bill introduced by Republican state Rep. Brian Stewart would increase that threshold to 60% and would mandate that the signatures needed to put an amendment on the ballot come from all 88 counties in the state, instead of 44, as currently required.

    Ohio state Senate President Matt Huffman backs raising the threshold and also supports holding an August special election to change the ballot initiative rules. If successful, the higher threshold would be in effect before November’s election when voters could consider adding abortion rights to the state constitution.

    Neither Huffman nor Stewart responded to interview requests from CNN.

    Ohio lawmakers recently voted to end August special elections, citing their expense and low participation. But Huffman recently told reporters in Ohio that a special election – with a potential price tag of $20 million – would be worth the expense if it helped torpedo the abortion initiative.

    “If we save 30,000 lives as a result of spending $20 million, I think that’s a great thing,” he said, according to Cleveland.com.

    The Ballot Initiative Strategy Center is tracking 109 measures across 35 states that could affect initiatives put to voters in 2024. Some would increase the threshold for an initiative to pass. Others would increase the minimum number of signatures – or require that they come from a broader geographic area – before an initiative could qualify for the ballot in the first place, Donat said.

    Many of the bills that seek to make it more difficult to pass ballot initiatives do not specifically target abortion issues. But they come as progressive groups increasingly turn to the initiative process as a way to bypass Republican-controlled legislatures and put a raft of issues – from legalizing marijuana to expanding Medicaid eligibility and boosting the minimum wage – directly to voters.

    “Attacks, through state legislatures, on the ballot measure process have been pretty consistent and pretty aggressive for the last several (election) cycles,” said Kelly Hall, executive director of the Fairness Project, which has helped pass progressive measures in red states.

    Hall said the abortion issue, while not the sole focus of current efforts to curb ballot initiatives, has put “additional fuel on an already burning fire.”

    In Missouri, a state law banning most abortions – including in cases of rape and incest – took effect last year after Roe was overturned. A group called Missourians for Constitutional Freedom has filed petition language that proposes adding abortion protections to the state constitution via ballot initiative. In recent cycles, voters in Missouri have expanded Medicaid eligibility and legalized recreational marijuana use through such initiatives.

    This year, the state’s Republican-controlled legislature is weighing making it harder for those initiatives to succeed. In February, the state House voted to raise the bar for amending the state constitution from a simple majority to 60%. Voters would have to approve the higher threshold.

    “I believe the Missouri Constitution is a living document but not an ever-expanding document,” Republican state Rep. Mike Henderson, the measure’s sponsor, said during House floor debate. “And right now, it has become an ever-expanding document.”

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  • Pope jokes he’s ‘still alive’ as he leaves hospital | CNN

    Pope jokes he’s ‘still alive’ as he leaves hospital | CNN

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    Rome
    CNN
     — 

    Pope Francis joked that he is “still alive” as he left a hospital in Rome where he spent the past few days being treated for a respiratory infection.

    He stopped to talk to journalists after being discharged from Rome’s Gemelli hospital on Saturday morning.

    The Pontiff was in good spirits when he replied to CNN’s Delia Gallagher’s questions about how he was feeling, telling her “[I’m] still alive, you know!”

    When asked if he got scared on Wednesday due to his respiratory problems, the Pope recalled what an “old man” told him after going through a similar situation.

    “An old man, older than me, told me after a situation like this: ‘Father, I didn’t see death, but I saw it coming. It’s ugly, eh!’”

    Pope Francis, 86, was taken to Gemelli hospital on Wednesday and was given antibiotics to treat infectious bronchitis.

    The pontiff – who as a young man suffered from severe pneumonia and had part of a lung removed – has had a recent history of medical issues.

    He has often been seen with a walking stick and sometimes uses a wheelchair due to pain in his right knee. Last year, he canceled a trip to Democratic Republic of Congo and South Sudan after doctors said he might also have to miss a later trip to Canada unless he agreed to have 20 more days of therapy and rest for his knee. He ultimately went to the DRC and South Sudan in February.

    Francis also suffers from diverticulitis, a common condition that can cause the inflammation or infection of the colon. In 2021, he had surgery to remove part of his colon.

    The Pope is expected to participate in a Palm Sunday Mass service in St Peter’s Square, the Vatican says.

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  • At least 5 killed and dozens others are hospitalized as tornadoes tear through the South and Midwest | CNN

    At least 5 killed and dozens others are hospitalized as tornadoes tear through the South and Midwest | CNN

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    CNN
     — 

    Devastating storms and tornadoes scraped the South and Midwest Friday into early Saturday, killing at least five people, injuring dozens more, trapping others in their homes, and damaging businesses and critical infrastructure – with the threat of more severe weather looming into Saturday afternoon.

    More than 50 preliminary tornado reports were made Friday in at least six states, including in Arkansas, where storms killed three people – two in the small city of Wynne and another person in North Little Rock, local officials said.

    Two people were killed in Indiana by a storm Friday night that damaged homes and a volunteer fire department near Sullivan, a city about a 95-mile drive southwest of Indianapolis, State Police Sgt. Matt Ames said.

    At least 50 people were sent to hospitals in Arkansas’ Pulaski County, where a tornado roared through the Little Rock area Friday, county spokesperson Madeline Roberts said. Five others were hospitalized after a tornado touched down Friday in Covington, Tennessee, according to a spokesperson for Baptist Memorial Health Care.

    Preliminary information shows at least 22 tornadoes were reported in Illinois, eight in Iowa, four in Tennessee, five in Wisconsin and a couple in Mississippi.

    In Arkansas, at least a dozen tornadoes were reported, including in the Little Rock area. Twisters in that state left homes nearly leveled, and roads were covered with what once was the roofs and walls of buildings.

    William Williams, who told CNN affiliate KATV he’s an employee at a Kroger supermarket in Little Rock, said he’s “thankful to be alive” after a tornado rolled near the area while he was working Friday afternoon. He’d taken shelter inside the store, and went outside afterward to see people injured, including a woman he said had a severe leg injury.

    “Everything happened in like five seconds. It came – boom,” Williams told KATV. “You could hear a lot of commotion and stuff. … I go outside, and it is crazy. People had blood all over their faces. … I’m just thankful that I’m alive.”

    About 100 miles east of Little Rock, the city of Wynne was “basically cut in half by damage from east to west,” Mayor Jennifer Hobbs told CNN Friday evening.

    “We are still in triage mode,” Hobbs said, adding that crews were trying to determine the severity of the damage and any potential injuries.

    In northern Illinois, more than 200 people were inside the Apollo Theatre in Belvidere for an event when its roof collapsed Friday night, leaving one person dead and dozens injured, the city fire chief said. The collapse came as a line of storms packing 50 mph winds and dumping hail moved through the area, according to officials and the National Weather Service. It wasn’t immediately clear whether the storm caused the theater’s roof to crumble.

    Twenty-eight people were taken to hospitals as a result of the collapse, Belvidere Fire Chief Shawn Schadle said.

    Friday’s severe storms came a week after severe weather walloped the Southeast and killed at least 26 people. An overnight tornado, which makes people most prone to extensive damages, leveled much of Rolling Fork, Mississippi, where estimated maximum winds of 170 mph roared.

    A team from Summit Energy say a prayer together before investigating a burst gas line in Cammack Village, Arkansas, near Little Rock, after a tornado swept through the area Friday.

    Tornadoes still could happen in southeastern Indiana, western Ohio and northern Kentucky on Saturday through 5 a.m. ET, according to the Storm Prediction Center. The area, which includes the cities of Dayton and Cincinnati, was under a tornado watch that warned of wind gusts up to 70 mph along with large hail.

    For Saturday, about 55 million people are under a slight risk of severe weather – a Level 2 of 5 – in parts of the Ohio Valley, the Northeast, including New York City and Philadelphia, and parts of the Southeast, according the Storm Prediction Center.

    Scattered strong to severe thunderstorms could happen in these areas, and hail and few tornadoes are possible, the center said.

    On Friday, large hail proved to be a dangerous when it bombarded northern Illinois, cracking and denting cars’ windshields, according to a Facebook post from the Fulton County Emergency Services and Disaster Agency.

    Police and firefighters get help from volunteers clearing downed trees on Keihl Avenue after storms ripped through the area on Friday in Sherwood, Arkansas.

    About 78 miles southeast of there, several businesses were “basically destroyed,” Sheriff Jack Campbell told CNN, and up to 40 homes were damaged around Sherman, less than 10 miles north of Springfield.

    Nearly 300,000 homes and businesses were in the dark early Saturday across Indiana, Illinois, Arkansas and Tennessee, with about one-third of the outages reported in Indiana, according to the tracking website PowerOutage.us.

    In Arkansas, Gov. Sarah Huckabee Sanders declared a state of emergency, noting the state will “spare no resource” in responding and recovering from the storm and activated the state’s National Guard.

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  • CDC to warn some travelers to watch for Marburg virus symptoms as it investigates outbreaks in Africa | CNN

    CDC to warn some travelers to watch for Marburg virus symptoms as it investigates outbreaks in Africa | CNN

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    CNN
     — 

    The US Centers for Disease Control and Prevention is sending personnel to Africa to help stop outbreaks of Marburg virus disease and is urging travelers to certain countries to take precautions. The CDC is also taking steps to keep infections from spreading to the United States.

    Equatorial Guinea and Tanzania are facing their first known outbreaks of Marburg virus, a viral fever with uncontrolled bleeding that’s a close cousin to Ebola. This week, the CDC urged travelers to both countries to avoid contact with sick people and to watch for symptoms for three weeks after leaving the area. Travelers to Equatorial Guinea should take enhanced precautions and avoid nonessential travel to the provinces where the outbreak is ongoing, the agency said.

    In the United States, the agency will post notices in international airports where most travelers arrive, warning them to watch for symptoms of the virus for 21 days and to seek care immediately if they become ill. They will also get a text reminder to watch for symptoms.

    The CDC is standing up a “center-led” emergency response; it’s not as all-encompassing as when the CDC stands up its Emergency Operations Center, such as for Covid-19 and mpox. But it will refocus the efforts and attention of the staff of its National Center for Emerging and Zoonotic Infectious Diseases to respond to the outbreaks, which are in two countries on opposite sides of Africa, indicating that the deadly hemorrhagic fever is spreading.

    Equatorial Guinea, on the coast in West Africa, declared an outbreak of Marburg virus disease in mid-February with cases spread across multiple provinces. As of March 22, Equatorial Guinea had 13 confirmed cases, including nine people who have died and one who has recovered, according to the World Health Organization. Nine CDC staffers are on the ground there. They have established a field laboratory and are assisting with testing, case identification and contact tracing.

    Tanzania, on the coast in East Africa, declared an outbreak of Marburg virus disease on March 21, with cases reported in two villages in the Kagera region, according to the CDC. As of March 22, Tanzania has had eight confirmed cases, including five deaths. The CDC has a permanent office in Tanzania that is assisting with the outbreak. It is sending additional staff to support those efforts.

    Marburg virus is a rare and deadly virus that causes fever, chills, muscle pain, rash, sore throat, diarrhea, weakness or unexplained bleeding or bruising. It is spread through contact with body fluids and contaminated surfaces. People can also catch it from infected animals. It is fatal in about half of cases who get it. Other countries in Africa have had to quell outbreaks before.

    In its early stages, the infection is difficult to distinguish from other illnesses, so a history of travel to either of those countries will be essential to helping clinicians spot it.

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  • How these mice navigating a virtual reality game may help Alzheimer’s patients | CNN

    How these mice navigating a virtual reality game may help Alzheimer’s patients | CNN

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    CNN
     — 

    Researchers in New York developed a virtual reality maze for mice in an attempt to demystify a question that’s been plaguing neuroscientists for decades: How are long-term memories stored?

    What they found surprised them. After forming in the hippocampus, a curved structure that lies deep within the brain, the mice’s memories were actually rooted through what’s called the anterior thalamus, an area of the brain that scientists haven’t typically associated with memory processing at all.

    “The thalamus being a clear winner here was very interesting for us, and unexpected,” said Priya Rajasethupathy, an associate professor at Rockefeller University and one of the coauthors of a peer-reviewed study published in the journal Cell this week. The thalamus “has often been thought of as a sensory relay, not very cognitive, not very important in memory.”

    This new research, however, indicates that it could play a vital role in converting short-term memories to long-term memories. And Rajasethupathy said that should make the thalamus a key area of study for researchers attempting to help patients who suffer from conditions such as Alzheimer’s, who are able to recall old memories but may have trouble remembering new information.

    “it implicates a part of the brain — the thalamus — in the long-term storage of memories in a way that wasn’t even hypothesized by anyone else,” said Loren Frank, a professor of physiology at the University of California San Francisco, who was not involved in the study.

    Rajasethupathy noted that neuroscientists have long known that memories take shape in the hippocampus, and is the focus of the vast majority of research around conditions like amnesia and Alzheimer’s.

    Past research has “led to this model where memories are formed in the hippocampus but then become independent over time and slowly stabilized in the cortex,” the wrinkled, outermost portion of the brain. The question has been exactly how memories travel from one area to another, Rajasethupathy said.

    “That process has been mysterious, I would say, for more than 50 years,” Rajasethupathy said.

    It was the right time for her lab to attempt to pinpoint an answer, she added, thanks to new technology that allowed the researchers to track activity in multiple parts of each subject’s brain. The innovations enabled the team to trace how memories are traveling as the mice learned to navigate a maze.

    “I think what they did was technically very challenging,” Frank said. “Particularly where they were trying to (observe) activity from multiple neurons in three different areas at once, using this sort of fiber microscopes. That’s a pretty state of the art thing.”

    The study — led by Rockefeller graduate students Andrew Toader and Josue Regalado, working inside Rajasethupathy’s lab — involved strapping the mice into a headpiece designed to hold them steady while a machine used optical fibers to record their brain activity.

    The maze took them into various “rooms” that offered either incentives, such as sugar water, or deterrents, like a puff of air to the face.

    The mice returned to the maze for days, enough time for them to create long-term memories.

    “The analogy would be your birthday dinner versus the dinner you had three Tuesdays ago,” Toader said in a statement. “You’re more likely to remember what you had on your birthday because it’s more rewarding for you—all your friends are there, it’s exciting—versus just a typical dinner, which you might remember the next day but probably not a month later.”

    Meanwhile, the researchers used chemicals to inhibit parts of the mice’s brains to determine how it affected their ability to create and store memories.

    Not only did they find that the anterior thalamus was a crucial waypoint for these memories — they also found that by stimulating that area in the rodents’ brains, the researchers were “able to help mice retain memories that they would usually forget,” according to a news release about the study.

    Rajasethupathy added, “Some memories are more important to us than others. We found that, not only do mice need the anterior thalamus to consolidate memories, but that by activating it, we could enhance consolidation of a memory that mice would usually forget.”

    Rajasethupathy noted that there were some limitations to the study. It does not, for example, indicate that traveling through the anterior thalamus is the only route memories can take on their way to long-term storage.

    “I want to be clear that this is not the end all be all,” she said. “Maybe everything isn’t consolidated through this pathway. But I’m very confident this is one very important circuit.”

    This study also relied on mice, who don’t have identical brains to humans but have proven to be extremely useful models for discovering how our own brains function. The long-term memory storage process takes weeks in rodents, whereas it can take months for humans, Rajasethupathy added.

    It’s also possible that different types of memory take different highways, she noted. There are explicit memories, which focus on facts, figures and specific data points, and implicit memories are typically tied to emotion and can form without a person realizing it. The thalamus may not be involved in the same manner for both types of information.

    But Frank, the UCSF professor, said the study will have broad implications for future research, spurring more investigations into the thalamus’ role in memory storage.

    “It’s nice for the field to getting to the point where we can think about the long-term evolution of memories and really try to understand how that works,” he said. “And the study is definitely a step in that direction.”

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  • Democratic congressman announces he has ‘serious but curable form of cancer’ | CNN Politics

    Democratic congressman announces he has ‘serious but curable form of cancer’ | CNN Politics

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    CNN
     — 

    Democratic Rep. Dan Kildee of Michigan announced in a statement on Friday that he has been “diagnosed with squamous cell carcinoma, a serious but curable form of cancer.”

    The congressman went on to say, “In a few weeks, I will have surgery to remove the cancer. The prognosis after surgery and treatment is excellent. My doctors have advised me it will take a few weeks to recover after the surgery. I’m eager to have this chapter behind me and get back to work. But in the meantime, I’ll be away from the office for a period of time. My congressional office will remain open to serve the people of Michigan’s Eighth Congressional District.”

    This story is breaking and will be updated.

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