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  • Trump unveils deal to expand coverage and lower costs on obesity drugs

    WASHINGTON (AP) — President Donald Trump unveiled a deal Thursday with drugmakers Eli Lilly and Novo Nordisk to expand coverage and reduce prices for the popular obesity treatments Zepbound and Wegovy.

    Known as GLP-1 receptor agonists, the drugs have soared in popularity in recent years, but patient access has been a consistent problem because of their cost — around $500 a month for higher doses — and insurance coverage has been spotty. More than 100 million American adults are obese, according to federal estimates.

    Coverage of the drugs for obesity will expand to Medicare patients starting next year, according to the administration, which said some lower prices also will be phased in for patients without coverage. Starting doses of new, pill versions of the treatments also will cost $149 a month if they are approved.

    “(It) will save lives, improve the health of millions and millions of Americans,” said Trump, in an Oval Office announcement in which he referred to GLP-1s as a “fat drug.”

    Thursday’s announcement is the latest attempt by the Trump administration to rein in soaring drug prices in its efforts to address cost-of-living concerns among voters. Pfizer and AstraZeneca recently agreed to lower the cost of prescription drugs for Medicaid after an executive order in May set a deadline for drugmakers to electively lower prices or face new limits on what the government will pay.

    As with the other deals, it’s not clear how much the price drop will be felt by consumers. Drug prices can vary based on the competition for treatments and insurance coverage.

    Obesity drugs are popular, but costly

    The obesity drugs work by targeting hormones in the gut and brain that affect appetite and feelings of fullness. In clinical trials, they helped people shed 15% to 22% of their body weight — up to 50 pounds or more in many cases.

    Patients usually start on smaller doses and then work up to larger amounts, depending on their needs. They need to stay on the the treatments indefinitely or risk regaining weight, experts say.

    The medications have proven especially lucrative for Lilly and Novo. Lilly said recently that sales of Zepbound have tripled so far this year to more than $9 billion.

    But for many Americans, their cost has made them out of reach.

    Medicare, the federally funded coverage program mainly for people ages 65 and over, now covers the cost of the drugs for conditions such as type 2 diabetes and cardiovascular disease, but not for weight loss alone. Trump’s predecessor, Joe Biden, proposed a rule last November that would have changed that, but the Trump administration nixed it.

    Few state and federally funded Medicaid programs, for people with low incomes, offer coverage. And employers and insurers that provide commercial coverage are wary of paying for these drugs in part because so many people might use them.

    The $500 monthly price for higher doses of the treatments also makes them unaffordable for those without insurance, doctors say.

    Trump tries to show he is in touch with cost-of-living concerns

    Thursday’s announcement comes as the White House is looking to demonstrate that Trump is in touch with Americans’ frustrations with rising costs for food, housing, health care and other necessities.

    “Trump is the friend of the forgotten American,” said Health and Human Services Secretary Robert F. Kennedy, Jr. at Thursday’s announcement. “Obesity is a disease of poverty. And overwhelmingly, these drugs have only been available for people who have wealth.”

    (Obesity rates actually are slightly higher for middle-income Americans than they are for those with the lowest and highest incomes, according to 2017-2020 data collected by the U.S. Centers for Disease Control and Prevention.)

    Kennedy had previously expressed skepticism about GLP-1s, but he was full of praise for Trump for pushing to help a broader segment of Americans have access to the drug.

    Trump, who has a history of commenting on people’s appearance, asked the officials who joined him in the Oval Office whether they had used the weight-loss medications.

    “Do you take any of this stuff, Howard?” Trump asked Commerce Secretary Howard Lutnick. “Not yet,” Lutnick replied. “He’s taking it,” the president said of Steven Cheung, who is the White House director of communications.

    The drug-pricing announcement came days after Democrats swept elections in races across the country. Economic worries were the dominant concern for those casting their ballots, according to findings from the AP voter poll.

    Plan calls for phased-in price reductions

    The White House sought to diminish price-reduction efforts by the previous Democratic administration as a gift to the pharmaceutical industry.

    Trump, instead, consummated a deal that ensures Americans aren’t unfairly financing the pharmaceutical industry’s innovation, claimed a senior administration official, who briefed reporters ahead of Thursday’s Oval Office announcement.

    Another senior administration official said coverage of the drugs will expand to Medicare patients starting next year. The program will start covering the treatments for people who have severe obesity and others who are overweight or obese and have serious health problems, the official said. Those who qualify will pay $50 copays for the medicine.

    Lower prices also will be phased in for people without coverage through the administration’s TrumpRx program, which will allow people to buy drugs directly from manufacturers, starting in January.

    Administration officials said the average price of the drugs sold on TrumpRx will start at around $350 and then drop to $245 over the next two years.

    A Novo Nordisk spokesperson declined to provide details on their pricing changes.

    Lilly said it will sell a starter dose of Zepbound for $299 a month and additional doses at up to $449. Both represent $50 reductions from current prices for doses it sells directly to patients.

    Administration officials said lower prices also will be provided for state and federally funded Medicaid programs. And starting doses of new, pill versions of the obesity treatments will cost $149 a month if they are approved.

    U.S. health regulators on Thursday separately agreed to dramatically expedite review of Lilly’s obesity pill, orforglipron. An FDA decision on Novo Nordisk’s Wegovy pill is expected later this year.

    Doctors who treat patients for obesity say help is needed to improve access. Dr. Leslie Golden says she has roughly 600 patients taking one of these treatments, and at least 75% struggle to afford them. Even with coverage, some face $150 copayments for refills.

    “Every visit it’s, ‘How long can we continue to do this? What’s the plan if I can’t continue?’” said Golden, an obesity medicine specialist in Watertown, Wisconsin. “Some of them are working additional jobs or delaying retirement so they can continue to pay for it.”

    ___

    AP Health Writer Matthew Perrone contributed to this report.

    ___

    The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

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  • India and Singapore agree to cooperate on chips as countries seek to strengthen partnership

    India and Singapore agree to cooperate on chips as countries seek to strengthen partnership

    India’s Prime Minister Narendra Modi speaks prior to a meeting with Brunei Sultan Hassanal Bolkiah at Istana Nurul Iman in Bandar Seri Begawan on September 4, 2024.

    Dean Kassim | Afp | Getty Images

    SINGAPORE — India and Singapore on Thursday signed memorandums of understanding for cooperation on a number of key areas including semiconductors, digital technologies, skill development and health care.

    The announcement comes during Indian Prime Minister Narendra Modi’s two-day visit to the Lion City, which began Wednesday following a trip to Brunei.

    “Singapore and India have built strong foundations for an enduring partnership. The next phase of the Singapore-India partnership is very promising,” Singapore Deputy Prime Minister Heng Swee Keat said at the Singapore-India Forum organized by the Singapore-India Partnership Foundation, Institute of South Asian Studies and the Singapore Business Federation.

    “Singapore, India and the rest of Asia must continue to strengthen on economic connectivity and integration, to allow for capital, ideas and talent to find their optimal uses,” he said.

    Although South Asia continues to be the world’s fastest-growing region — and India the world’s fastest-growing major economy — the region is still playing catch up in terms of GDP per capita.

    India’s GDP per capita currently stands at $2,730, significantly lower than that of the U.S. ($85,370), China ($13,140), Germany ($54,290) and Japan ($33,140), data from the International Monetary Fund showed. Those four economies are also the same ones the South Asian nation is currently trailing behind in terms of overall GDP.

    “Singapore is not just a partner, it is an inspiration for every developing country. We want to create a bunch of Singapores in India,” Modi said in a meeting with Wong.

    On Wednesday, Modi and Singapore’s Prime Minister Lawrence Wong visited Singaporean semiconductor and electronics company AEM, signaling their intent to increase cooperation in chips.

    Increased collaboration can also help both nations overcome “common challenges” such as climate change, aging populations and public health, Heng highlighted.

    Modi’s entourage also included Minister of External Affairs S. Jaishankar, National Security Advisor Ajit Doval along with other government officials.

    In a post on X, Modi called Wong a friend and said, “We both agreed on the need to boost trade relations.”

    The country is India’s sixth largest trading partner, with 3.2% share of India’s overall trade. Imports from Singapore in financial year 2024 amounted to $21.2 billion, while exports totaled $14.4 billion.

    Asia’s biggest financial hub is also the largest source of foreign direct investments into India. Cumulative FDI inflows from Singapore to India stood at almost $160 billion from April 2000 to March 2024, amounting to almost a quarter of total FDI inflows to the South Asian nation.

    Lessons from Singapore’s playbook

    Why Apple's betting big on making iPhones in India

    Apple said in April that it will invest over $250 million to expand its Ang Mo Kio campus in Singapore, with CEO Tim Cook saying the country is “truly a one-of-a-kind place.” A month later, global biopharmaceutical firm AstraZeneca announced plans to build a $1.5 billion manufacturing facility in the city.

    India’s manufacturing industry has also made significant strides in the past few years, with Apple supplier Foxconn committing to ramping up investments in the country, while Micron Technology is set to create its first India-made semiconductor chip by early 2025.

    However, the world’s fifth-largest economy still has a long way go.

    “When you are deploying billions of dollars to promote a domestic industry, there are a lot of nuts and bolts that need to be sorted out. So this is absolutely the time for India to learn from Singapore’s successful playbook,” said Samir Kapadia, CEO of India Index and managing principal at Vogel Group.

    In the last seven years, Singapore has opened skill development centers in various Indian states, such as New Delhi and the north-eastern city of Guwahati.

    “This is not just about incentivizing investments for the semiconductor industry, but learning how to govern massive industrial planning and incentive initiatives,” Kapadia added.

    — CNBC’s Vinay Dwivedi contributed to this report.

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  • Federal judge declines to block Medicare drug price negotiations

    Federal judge declines to block Medicare drug price negotiations

    A pharmacist holds a bottle of the drug Eliquis, made by Pfizer Pharmaceuticals, at a pharmacy in Provo, Utah, January 9, 2020.

    George Frey | Reuters

    A federal judge on Friday declined to block the Biden administration from implementing Medicare drug price negotiations, upholding for now a controversial process that aims to make costly medications more affordable for older Americans.

    Judge Michael Newman of the Southern District of Ohio issued a ruling denying a preliminary injunction sought by the Chamber of Commerce, one of the largest lobbying groups in the country, which aimed to block the price talks before Oct. 1.

    That date is the deadline for manufacturers of the first 10 drugs selected for negotiations to agree to participate in the talks.

    But Newman, a nominee of former president Donald Trump, also declined to grant the Biden administration’s motion to dismiss the case entirely.

    Instead, he asked the Chamber to amend its complaint by Oct. 13 to clarify certain details in the case.

    Newman also gave the Biden administration until Oct. 27 to renew its motion to dismiss the case.

    He said “a final determination on standing issues will be made following a short (60-day) discovery period and—assuming they are filed—renewed motions to dismiss.”

    The ruling from Newman is a blow to the pharmaceutical industry, which views the process as a threat to its revenue growth, profits and drug innovation.

    President Joe Biden’s Inflation Reduction Act, which passed in a party-line vote last year, gave Medicare the power to directly hash out drug prices with manufacturers for the first time in the federal program’s nearly 60-year history

    The Chamber, which represents some companies in the industry, and drugmakers like Merck and Johnson & Johnson filed at least eight separate lawsuits in recent months seeking to declare the negotiations unconstitutional. But the Chamber’s suit was the only one seeking a preliminary injunction. 

    Michael Newman, U.S. District Court Judge Ohio

    Source: U.S. District Court

    The Chamber’s lawsuit argues that the program violates drugmakers’ due process rights under the Fifth Amendment by giving the government the power to effectively dictate prices for their medicines.

    The Chamber said an appeals court established a precedent that when the government sets prices, it must provide procedural safeguards to ensure a company receives a reasonable rate and fair return on investment. It stems from the 2001 case Michigan Bell Telephone Co. v. Engler, according to the Chamber.

    The Medicare negotiations do not provide these safeguards and impose price caps that are well below a drug’s market value, the Chamber argued.

    “There is a very, very high risk, maybe a guarantee, but certainly a very, very high risk, that this regime will result in prices that are unfair,” Jeffrey Bucholtz, an attorney for the Chamber, told judge Newman during a hearing earlier this month.

    He added that drugmakers either must agree to the price the government sets, or face an excise tax of up to 1,900% of U.S. sales of the drug.

    But lawyers for the DOJ said during the hearing that the program was far from compulsory. Drugmakers can choose the alternative to those two options: Withdraw their voluntary participation in the Medicare and Medicaid programs, according to attorney Brian Netter. 

    “The measure of relief here is for manufacturers to decide whether they want to stay in the program under the terms that are on offer,” Netter said. “If they choose not to, that’s their prerogative.”

    The other suits are scattered in federal courts around the U.S.

    Legal experts say the pharmaceutical industry hopes to obtain conflicting rulings from federal appellate courts, which could fast-track the issue to the Supreme Court. 

    Medicare covers roughly 66 million people in the U.S., according to health policy research organization KFF. The drug price talks are expected to save the insurance program an estimated $98.5 billion over a decade, the Congressional Budget Office said. 

    In August, the Biden administration unveiled the 10 drugs that will be subject to the first round of price talks, officially kicking off a lengthy negotiation process that will end in August 2024. The reduced prices for those initial medications won’t go into effect until January 2026.

    That includes blood thinners from Bristol-Myers Squibb and J&J, and diabetes drugs from Merck and AstraZeneca. It also includes a blood cancer drug from AbbVie, one of the companies represented by the Chamber of Commerce. 

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  • Stocks making the biggest moves premarket: Intel, Roku, Procter & Gamble and more

    Stocks making the biggest moves premarket: Intel, Roku, Procter & Gamble and more

    Signage outside Intel headquarters in Santa Clara, California, on Monday, Jan. 30, 2023.

    David Paul Morris | Bloomberg | Getty Images

    Check out the companies making headlines before the bell.

    Intel — Shares popped 6.7% after the chipmaker posted better-than-expected second-quarter results and a return to profitability after two consecutive losing periods. Intel’s forecast for the third quarter also came in above analyst expectations. The company reported adjusted earnings of 13 cents a share on revenues of $12.95 billion.

    Roku — The streaming stock rallied nearly 10% after reporting a narrower-than-expected loss for the second quarter. Roku reported a loss of 76 cents a share and revenues of $847 million. Analysts polled by Refinitiv had anticipated a loss of $1.26 per share and $775 million in revenue.

    Biogen — Biogen shares moved slightly lower after the biotechnology company said it’s acquiring Reata Pharmaceuticals for $172.50 per share, in a cash deal valued at about $7.3 billion. Shares of Reata soared more than 51% on the news.

    Procter & Gamble — The consumer giant saw shares rise more than 1% in premarket trading after the company reported quarterly earnings and revenue that beat analysts’ expectations. However, P&G released a gloomy outlook for its fiscal 2024 sales that fell short of Wall Street’s estimates.

    Exxon Mobil — Shares moved slightly lower after the oil stock posted mixed second-quarter results. The company reported earnings of $1.94 a share, excluding items, that fell short of the $2.01 expected by analysts, per Refinitiv. Revenues came in at $82.91 billion, above the expected $80.19 billion.

    Chevron — The oil stock lost nearly 1% even after reporting a beat on the top and bottom lines for the second quarter. Earnings fell from a year ago due to a drop in oil prices.

    First Solar – Shares soared 12% after the solar company posted earnings per share of $1.59 on revenue of $811 million for the second quarter. Those results beat Wall Street expectations of 96 cents per share on revenue of $721 million, according to Refinitiv. The company also announced plans to invest up to $1.1 billion to build a fifth manufacturing facility in the United States.

    Enphase Energy – Shares of Enphase dropped more than 15% after the company posted second-quarter revenue Thursday of $711 million that fell short of analyst estimates of $722 million, according to Refinitiv. The stock also faced a wave of downgrades Friday morning from Deutsche Bank, Wells Fargo and Roth MKM.

    Sweetgreen – Shares of the salad chain slid more than 13% after the company posted weak sales that missed Wall Street expectations in the second quarter and a net loss of $27.3 million, or 24 cents per share. Sweetgreen did say it’s aiming to turn a profit for the first time by 2024.

    Ford Motor – The automaker said adoption of electric vehicles is going more slowly than the company forecast and that it expects to lose $4.5 billion on the EV business this year, widening losses from roughly $3 billion a year earlier. Otherwise, Ford posted strong quarterly earnings that beat Wall Street expectations and raised its full-year guidance. Shares were flat in premarket trading.

    Juniper Networks — Shares of the technology company fell 8% after Juniper’s third-quarter guidance came in lighter than expected. The company said it expects earnings per share between 49 cents and 59 cents, with revenue between $1.34 billion and $1.44 billion. Analysts had penciled in 62 cents per share and $1.48 billion of revenue. The company’s second-quarter results did come in slightly above expectations.

    AstraZeneca — U.S. listed shares of the drugmaker added more than 5% before the bell. The U.K.-based company reported second-quarter earnings of $2.15 per share on $11.42 billion in revenue. That surpassed the EPS of $1.95 expected by analysts polled by Refinitiv on revenues of $11.03 billion. AstraZeneca also said it would buy a portfolio of preclinical rare disease gene therapies from Pfizer for up to $1 billion.

    Xpeng — The Chinese electric vehicle stock jumped more than 6% in the premarket. Jefferies upgraded shares to a buy from a hold, citing Xpeng’s joint development plan with Volkswagen

    New York Community Bancorp — The regional bank stock rose about 2% before the bell after JPMorgan upgraded New York Community Bancorp to an overweight rating from neutral. The Wall Street firm called the company a “massive market share taker” in its upgrade.

    Mondelez International — Mondelez International added 2.7% before the bell on strong second-quarter results. The snack maker on Thursday reported earnings of 76 cents a share, excluding items, on $8.51 billion in revenue. Analysts polled by Refinitiv had estimated EPS of 69 cents and revenues of $8.21 billion.

    — CNBC’s Tanaya Macheel, Yun Li and Jesse Pound contributed reporting

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  • FDA advisors recommend AstraZeneca antibody to protect babies from RSV

    FDA advisors recommend AstraZeneca antibody to protect babies from RSV

    Narisara Nami | Moment | Getty Images

    A panel of independent advisors to the Food and Drug Administration unanimously recommended Thursday that the antibody nirsevimab be approved for use to protect infants from respiratory syncytial virus, the leading cause of hospitalization among newborns.

    If the FDA approves nirsevimab, the antibody would become the first medical intervention available in the U.S. that can protect all infants from RSV. The FDA, which is not obligated to follow the recommendation of its advisory panel, is expected to make a final decision on nirsevimab in the third quarter of this year.

    Nirsevimab is a monoclonal antibody made by AstraZeneca. The medication would be marketed by Sanofi.

    The advisory panel voted 21-0 to recommend its approval.

    RSV kills nearly 100 babies in the United States every year.

    Infants hospitalized with RSV often require oxygen support, intravenous fluids and are sometimes placed on a ventilator to support their breathing.

    The virus is a major public health threat. A surge in RSV infections last year overwhelmed children’s hospitals leading to calls for the Biden administration to declare a public health emergency in response.

    RSV circulates at the same time as the flu and Covid-19, which puts added pressure on hospitals.

    There is another monoclonal antibody used against RSV called palivizumab. But this antibody is only for preterm infants and those with lung and congenital heart conditions that are high risk of severe disease. Palivizumab also has to be administered monthly.

    Nirsevimab, by contrast, would also be administered to healthy infants, who make up a majority of the hospitalizations. It is also given as a single dose, which would make administration easier.

    Nirsevimab is not considered a vaccine because it is a monoclonal antibody.

    It is unclear whether the federal Vaccines for Children program will provide nirsevimab for uninsured and underinsured children for free because the antibody is regulated as a drug.

    Nirsevimab is already approved in Canada, Europe and the United Kingdom.

    Efficacy

    Nirsevimab was up to 75% effective at preventing lower respiratory tract infections that required medical attention and 78% effective at preventing hospitalizations, according a review by the FDA.

    A more conservative estimate by FDA put the antibody’s effectiveness at about 48% against lower respiratory tract infections that required medical attention. This estimate assumed patients with missing data on their health outcomes had lower respiratory tract infections that required medical attention.

    CNBC Health & Science

    Read CNBC’s latest health coverage:

    Nirsevimab is administered as a single injection with the dose depending on the infant’s weight. Infants that weigh less than 5 kilograms would receive a 50 mg injection for their first RSV season, and those weighing 5 kilograms or greater would receive a 100 mg injection.

    Children less than two years old who remain at risk for severe RSV in their second season would receive a single 200 mg injection of nirsevimab.

    Safety

    The FDA did not identify any safety concerns in its review of nirsevimab.

    Other monoclonal antibodies have been associated with serious allergic reactions, skin rashes and other hypersensitivity reactions.

    The FDA did not find any cases of serious allergic reactions in the nirsevimab trials and cases of skin rash and hypersensitivity reactions were low in infants who received the antibody. But Dr. Melissa Baylor, an FDA official, said cases of these side effects will likely occur if nirsevimab is approved.

    Twelve infants who received nirsevimab in the trials died. None of these deaths were related to the antibody, according to the FDA’s review.

    Four died from cardiac disease, two died from gastroenteritis, two died from unknown causes but were likely cases sudden infant death syndrome, one died from a tumor, one died from Covid, one died from a skull fracture, and one died of pneumonia.

    “Most deaths were due to an underlying disease,” Baylor said. “none of the deaths appeared to be related to nirsevimab.”

    There is very close attention to safety due to historical failures in the development of RSV vaccines. Scientists first tried to develop a vaccine in the 1960s with an inactivated virus, but that shot actually made disease from RSV worse in some children when they received their first natural infection, resulting in the death of two infants.

    Manish Shroff, head of patient safety at AstraZeneca, said the company will keep a close eye on the safety of nirsevimab through a large global monitoring system: “Safety is of utmost importance,” he said.

    Baylor said there are also unanswered questions about how nirsevimab would interact with vaccines in development that confer protective antibodies to the fetus by administering the shot to the mother.

    It’s unclear if giving nirsevimab to infants whose mothers received such RSV vaccines would provide additional protection or create potential safety issues,” Baylor said.

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  • Hospitalizations on the rise in New York City as new COVID strains spread rapidly

    Hospitalizations on the rise in New York City as new COVID strains spread rapidly

    Hospitalizations are rising again in New York City with the spread of new COVID-19 subvariants that are better at evading immunity. Cases of flu and respiratory syncytial virus, or RSV, are also increasing.

    State data show about 1,100 patients hospitalized with COVID as of Oct. 24, up from 750 in mid-September, as the New York Times reported. Case numbers have held steady, although with many people testing at home where data are not being collected, those numbers are not reliable.

    Data from the Centers for Disease Control and Prevention show that the omicron sublineages named BQ.1 and BQ.1.1 accounted for 42.5% of all cases in the New York region in the week through Oct. 29, up from 37% the previous week.

    That was more than the BA.5 omicron subvariant, which accounted for 35.7% of new cases in the New York region in the latest week. The two sublineages were not even registering as recently as three weeks ago, demonstrating just how fast they are spreading.

    Experts are also concerned about a nationwide surge in RSV, which can cause breathing difficulties in small children and older adults and for which there is currently no vaccine.

    There was good news from Pfizer Inc., however, which said Tuesday that data from a late-stage trial of an RSV vaccine had proved effective in preventing severe illness in children up to 6 months old.

    The Phase 3 trial found that the vaccine, given to pregnant mothers, achieved vaccine efficacy of 81.8% in infants from birth through the first 90 days of life. The trial found efficacy of 69.4% through the first 6 months of life.

    Pfizer
    PFE,
    +3.14%

    said it expects to make its first U.S. regulatory application for the vaccine by the end of 2022 and to follow on with other regulatory bodies. It will also submit the results of the trial for peer review in a scientific journal.

    The daily U.S. average for new COVID cases stood at 37,665 on Monday, according to a New York Times tracker, which was flat as compared with two weeks ago. The daily average for hospitalizations was up 2% to 27,184, while the daily average for deaths was down 3% to 348. 

    Coronavirus Update: MarketWatch’s daily roundup has been curating and reporting all the latest developments every weekday since the coronavirus pandemic began

    Other COVID-19 news you should know about:

    • Apple 
    AAPL,
    -1.75%

    supplier Foxconn
    2317,

    said Tuesday it has quadrupled bonuses for workers at its Zhengzhou plant in central China as it seeks to quell discontent over COVID restrictions and retain staff at the giant iPhone manufacturing site, Reuters reported. Daily bonuses for employees, who are part of a Foxconn unit responsible for making electronics including smartphones, have been raised to 400 yuan ($55) a day for November from 100 yuan, according to the official WeChat account of Foxconn’s Zhengzhou plant. The move comes after workers fled the site over the weekend to avoid COVID curbs after complaining about their treatment and provisions via social media.

    Workers at the world’s biggest assembly site for Apple’s iPhones walked out as Foxconn has struggled to contain a COVID-19 outbreak. The chaos highlights the tension between Beijing’s rigid pandemic controls and the urge to keep production on track. Photo: Hangpai Xinyang/Associated Press

    • The Wall Street Journal reported Tuesday that Hong Kong stocks appeared to be rallying after an anonymous post on Chinese social media suggested that the government may intend to soften pandemic-related restrictions beginning in March. Other outlets also reported on the rumor. American depositary receipts for Chinese companies surged on the news.

    See: Alibaba and Nio among Chinese stocks surging as hopes build about potential reopening

    • Pfizer’s COVID antiviral Paxlovid brought in $7.5 billion in sales in the third quarter of the year, compared with a FactSet consensus of $7.6 billion. The drug company also reiterated guidance for Paxlovid revenues in 2022, saying it still expects $22 billion in sales for the year. The FactSet consensus is $22.5 billion. Pfizer raised its full-year revenue guidance for the company’s Comirnaty COVID vaccine by $2 billion to $34 billion. The guidance includes doses expected to be delivered in fiscal 2022, primarily under contracts signed as of mid-October.

    • AstraZeneca PLC’s
    AZN,
    +1.77%

    AZN,
    +0.90%

    COVID vaccine Vaxzevria has been granted full marketing authorization in the European Union, Dow Jones Newswires reported. The Anglo-Swedish pharmaceutical giant said Vaxzevria has been shown to be effective against all forms of the virus. Vaxzevria was originally granted conditional marketing authorization due to the urgency of the COVID-19 pandemic, it said.

    Here’s what the numbers say:

    The global tally of confirmed cases of COVID-19 topped 630.6 million on Monday, while the death toll rose above 6.59 million, according to data aggregated by Johns Hopkins University.

    The U.S. leads the world with 97.5 million cases and 1,070,429 fatalities.

    The Centers for Disease Control and Prevention’s tracker shows that 226.9 million people living in the U.S., equal to 68.4% of the total population, are fully vaccinated, meaning they have had their primary shots.

    So far, just 22.8 million Americans have had the updated COVID booster that targets the original virus and the omicron variants, equal to 7.3% of the overall population.

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