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Tag: antibodies

  • Plasma: The Functional, Natural Miracle Ingredient for Dogs and Cats! | Animal Wellness Magazine

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    Spoil and support pets with food, treats, and supplements featuring plasma: It’s tasty, healthy, and natural!

    When buying pet food, treats, and supplements, modern pet parents don’t just look for quality ingredients or complete and balanced nutrition. They also place emphasis on things like functional ingredients with health benefits. Plasma is a clean, natural, and highly digestible nutrient source that stands out as a functional ingredient because it benefits health and helps the planet. Learn more about plasma, how it supports whole-body health, and great products that feature it.

    Plasma Supports Human Health and Pet Health

    Plasma is the liquid component of blood. So when you donate blood, you’re giving plasma, a life-saving gift used around the world every day to help people survive and thrive. And just like plasma supports human health, so too can it play a meaningful role in pet health and nutrition. Plasma sourced from pigs and cattle is collected and dried, preserving the amino acids, nutrients, bioactive compounds, and highly digestible proteins. It’s a tasty, functional ingredient that can be added to pet foods, treats, and supplements to support vitality, well-being, and everyday health.

    Adding Plasma to a Dog’s or Cat’s Diet Is Good for the Whole Body

    Plasma about 70% to 80% protein, so you can see right away one of the main benefits for dogs and cats. Four-legged family members rely on protein-rich diets to build and repair tissues, produce enzymes and hormones, and support overall growth, function, and energy. Beyond that, plasma also contains a myriad of other beneficial compounds, including:

    • Amino acids
    • Electrolytes
    • Minerals
    • Antibodies
    • Immunoglobulins
    • Bioactive peptides
    • Growth factors

    Together, these compounds have a systemic effect, supporting the immune system and its ability to respond to stress and inflammation. They also help with digestive health, the gut microbiome, nutrient absorption, muscle development, skin and coat health, and energy levels.

    What’s more, plasma is a valuable byproduct of meat processing. Reclaiming plasma from the meat industry reduces waste, minimizes environmental impacts, and supports a more efficient food system.

    Easy Ways to Add Plasma to Your Dog’s or Cat’s Diet

    Plasma is a powerful, natural, sustainable ingredient that supports canine and feline health at every life stage. It delivers essential nutrients, helps manage stress and inflammation, supports immunity, and promotes overall vitality, keeping dogs and cats active, resilient, and thriving. When you add food, treats, and supplements with plasma to their diet, you’re supporting whole-body health for them and helping the planet too.

    Visit APC to learn more about plasma for pet health!

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    Animal Wellness is North America’s top natural health and lifestyle magazine for dogs and cats, with a readership of over one million every year. AW features articles by some of the most renowned experts in the pet industry, with topics ranging from diet and health related issues, to articles on training, fitness and emotional well being.

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  • More Sleep Boosts Vaccine Effectiveness: Study

    More Sleep Boosts Vaccine Effectiveness: Study

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    March 14, 2023 – Want to get the maximum level of protection out of vaccines? Then make sure to get at least 7 hours of sleep before and after getting a shot, a new study suggests.

    Compared to people who slept at least 7 hours, people who slept less than 6 hours in the days surrounding a vaccine shot generated significantly fewer antibodies, which are what recognize and kill viruses and bacteria in the body.

    Because the effectiveness of many vaccines declines over time, the boost essentially makes the vaccine’s protection last longer – by up to 2 months, the researchers found. 

    “Good sleep not only amplifies but may also extend the duration of protection of the vaccine,” researcher Eve Van Cauter, PhD, professor emeritus at the University of Chicago, said in a statement.

    The study, published Monday in Current Biology, reanalyzed past research on the connection between sleep and the effectiveness of vaccines for flu and hepatitis. The researchers sought to understand the connection because of indications that people developed varying levels of immunity after receiving the same COVID-19 vaccines. Sleep studies specific to COVID vaccines are not yet available, so the researchers decided to evaluate existing studies and translate those findings to what’s known about COVID vaccines.

    “How we stimulate the immune system is the same whether we’re using an mRNA vaccine for COVID-19 or an influenza, hepatitis, typhoid, or pneumococcal vaccine. It’s a prototypical antibody or vaccine response, and that’s why we believe we can generalize to COVID,” researcher Michael Irwin, MD, an expert from UCLA who specializes in the relationship between psychological processes, the nervous system, and immunity, told CNN.

    When the researchers looked at vaccine response in different groups, the effects of sleep were greatest among men and in people ages 18 to 60 years old. The researchers said more research on the effects in women is needed because variations in their hormone levels impact the immune system. 

    They also found that vaccine effectiveness was not as dramatically impacted by reduced sleep in people age 65 and older. The authors suggested that this is because older people already tend to sleep less than younger people.

    The findings are important because they offer a way for people to modify their own behavior to improve their health and immunity, Van Cauter said.

    “When you see the variability in protection provided by the COVID-19 vaccines — people who have preexisting conditions are less protected, men are less protected than women, and obese people are less protected than people who don’t have obesity,” she said. “Those are all factors that an individual person has no control over, but you can modify your sleep.”

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  • A New T-Cell activation assay based on Hyris qPCR Technology marks a disruptive approach for the detection of SARS-CoV-2 specific cellular immunity

    A New T-Cell activation assay based on Hyris qPCR Technology marks a disruptive approach for the detection of SARS-CoV-2 specific cellular immunity

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    A scientific paper recently published in Nature Biotechnology reveals new research regarding how we track and monitor T-cell patients’ immunity to SARS-CoV-2, leveraging the unique characteristics of Hyris System™. The study results from a joint effort of an international research team from the Icahn School of Medicine at Mount Sinai, Singapore Duke-NUS Medical School, laboratory diagnostic service providers Synlab, and Hyris.

    Press Release
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    Jun 15, 2022


    LONDON, June 15, 2022 (Newswire.com)
    –
    With over 460 million global cases thus far, 6 million of which have resulted in death, the COVID-19 pandemic from SARS-CoV-2 proved to be a dire health crisis on a global scale. In this concerning scenario, the unprecedented effort by the international scientific community is even more remarkable and led – in record time – to the deployment of mRNA and viral vector-based vaccines. With more than 10 billion total vaccine doses administered worldwide, vaccination campaigns have already started to attenuate this global crisis. In order to maximize vaccine effectiveness, the efficacy and duration of protective immunity will need to be systematically assessed and monitored as widely as possible.

    A team of internationally renowned medical scientists recently published a related paper in Nature Biotechnology, addressing the efficacy and sensitivity of a new type of assay to detect SARS-CoV-2 cellular immunity.

    “To date, antibody tests have been the typical, if not the only clinical endpoints commonly used to measure the immune response to SARS-CoV-2,” explains Antonio Bertoletti, Professor at Duke-NUS Medical School. “Both the humoral (antibodies) and cellular immune response act in coordination to achieve long-term protection from viral infections. Antibodies are important for preventing infection, protecting the body from disease, while cellular immunity is essential to eliminate virus-infected cells, thus helping to fight the disease itself,” concludes Professor Bertoletti. 

    Therefore, according to the study, measuring the T-cells’ response is a new disruptive approach to fighting SARS-CoV-2. An individual negative to an antibody test could still be protected thanks to responsive T-cells.

    This new study thus shows the relevance of a quantitative PCR approach to T-cell testing, thanks to the joint effort with SYNLAB, one of the world’s leading providers of laboratory diagnostic services, and Hyris, a global biotech company focused on AI-powered genetic analysis.

    The research leveraged Hyris’ signature technology, the disruptive Hyris System™.

    “These highly scalable screening methods will be particularly important, to monitor the magnitude and duration of functional cellular immunity towards emerging variants, thus helping to prioritize revaccination strategies in vulnerable populations,” states Cristina Lapucci, Head of Genetics and Molecular Biology at SYNLAB Italy.

    “We have been very committed to putting our System at such prestigious partners’ service,” says Stefano Lo Priore, Founder and CEO at Hyris. “Many medical institutions worldwide already adopted our technology, embracing the unprecedented simplicity, connectivity, and scalability of the Hyris SystemTM.”

    The rapid deployment of SARS-CoV-2 vaccines to a large proportion of the population now suggests new approaches to measure the duration of the immune response, and the potential need for vaccine boosters should be evaluated.

    “The assays used in our study rely on the quantification of CXCL10 mRNA after incubation of whole blood with SARS-CoV-2 specific peptides. The levels of induced CXCL10 transcripts correlate robustly with the IFN-gamma produced by activated antigen-specific T cells, serving as a proxy to detect cellular immunity in COVID-19 recovered and SARS-CoV-2 vaccinated subjects,” points out Ernesto Guccione, PhD, Professor of Oncological Sciences, and Pharmacological Sciences, at Icahn Mount Sinai.

    “This is particularly important after the emergence of SARS-CoV-2 variants like Omicron that evade most of the neutralizing ability of antibodies, but not that of T-cells,” continues Megan Schwarz, a graduate student at Icahn School Mount Sinai and first author of the manuscript. “Precise measurement of cellular responses underlying virus protection, therefore, represents a crucial parameter of immune defence.”

    “The solutions already present on the market are usually performed based on the traditional fluorescence methodologies typically used in the immunological domain,” adds Jordi Ochando, PhD, Assistant Professor of Oncological Sciences, Medicine (Nephrology), and Pathology, Molecular, and Cell-Based Medicine at Icahn Mount Sinai. “This research demonstrates that CXCL10 mRNA expression confirms data obtained with traditional methods (i.e., ELISpot) compared with naïve, COVID-19 convalescent and SARS-CoV-2 vaccinated subject,” he concludes.

    This study could prove a key solution to further support the scientific community playing a strategic role in facing this global challenge.

    Contact a Hyris expert to discover how to perform beyond your current diagnostic capability at info@hyris.net.

    Source: Hyris

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