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Tag: Alternative Medicine

  • Judge remains undecided on treatment plan for man charged with stalking Jennifer Aniston

    LOS ANGELES — LOS ANGELES (AP) — A judge remained undecided Friday on the treatment and placement plan for a man charged with stalking Jennifer Aniston and ramming his car into the front gate of her home.

    Jimmy Wayne Carwyle, a 48-year-old from Mississippi, has pleaded not guilty to felony stalking and vandalism. But in May, Judge Maria Cavalluzzi found him not competent to stand trial after evaluations from two experts. At Friday’s hearing in a Los Angeles court dedicated to mental health cases, she heard arguments on Carwyle’s treatment and placement.

    Aniston’s lawyer, Blair Berk, spoke on her behalf for the first time, detailing two years of Carwyle’s harassment and stalking, including various failed attempts to make physical contact with the actor.

    Cavalluzzi said she leaned toward sending Carwyle to a mental health treatment alternative to imprisonment. She requested another hearing, scheduled for later this month, to hear from a mental health professional before making a final decision.

    Prosecutors and Aniston’s attorney will have a chance to weigh in, Cavalluzzi said.

    The judge acknowledged Aniston’s “very real” fear, but she said she can’t ignore the opinions of mental health professionals who have evaluated Carwyle and deemed him not a danger to society. The alternative treatment option offers community-based housing, treatment and support services as opposed to incarceration.

    Prosecutors alleged Carwyle had been harassing the “Friends” star with a flood of voicemail, email and social media messages for two years before driving his Chrysler PT Cruiser through the gate of her home in the wealthy Bel Air neighborhood of Los Angeles on May 5, “only feet away from where she was,” Berk said.

    Carwyle had a stated and “persistent delusion” to impregnate Aniston with three children, Berk said, and “there is simply no way to prevent him from carrying out his delusion if he walks out.”

    The prosecution expressed concern that if Carwyle were offered the treatment in Los Angeles, nothing would stop him “from traveling those few miles to Ms. Aniston,” Berk said.

    Berk and William Donovan, the deputy district attorney, argued Carwyle was a present danger to Aniston and those around her. Berk said he attempted to enter her property twice, but was turned away.

    Carwyle’s lawyer, Robert Krauss, said his client qualifies for alternative treatment, arguing that he hasn’t been convicted of violent crimes. Granting him alternative treatment, “is not like giving him a break or showing him leniency,” Krauss said. “Its just one thing and one thing only — and that is absolute, pure faithfulness of the law.”

    Krauss also referenced a report from the probation department, which recommended Carwyle be granted probation and 90 days in jail if convicted, much less than the over three years maximum sentence for his two charges. Carwyle has been in jail since May and, if convicted, could be let out with time served.

    Carwyle was present at the hearing and addressed questions from Cavalluzzi, saying he “wasn’t right in the head,” when asked about the text messages he sent Aniston. He said he has been taking medication, which is keeping him focused, and admitted his wrongdoing.

    When Cavalluzzi asked how she can be sure he won’t walk away from the treatment program — a stated concern from the prosecution — Carwyle responded, “You have my word.”

    Berk said Carwyle “traveled thousands of miles over a year ago “after sending thousands of messages” that reflected “his delusions and intentions to not just make contact with Ms. Aniston, but to commit criminal wrongs against her, sexual violence against her.” She added that Carwyle stressed in his messaging that he “would be unabated by doctors or others or FBI intervening.”

    Donovan argued that a state hospital is a “much safer, much more effective place for him to go,” and will offer the treatment Carwyle needs to address his delusions. The prosecution also argued there’s no evidence that Carwyle’s delusions toward Aniston have stopped, even with medication.

    Carwyle has been under involuntary medication for the past few months. Krauss said that Carwyle’s actions toward Aniston were “just the product of psychosis from someone who is unmedicated.” The government must keep its “promise of treatment rather than punishment and of rehabilitation rather than incarceration,” he said.

    The hearing was postponed several times in recent months as Carwyle at first objected to the incompetence finding and asked for an opinion, and both sides sought more time to examine the case.

    Carwyle remains jailed, but he is under a judge’s order not to contact or get near Aniston.

    Authorities said Aniston was home at the time of the gate crash, but he did not come into contact with her. A security guard stopped him in her driveway until police arrived. No one was injured.

    Carwyle also faces an aggravating circumstance of the threat of great bodily harm.

    Aniston became one of the biggest stars in television in her 10 years on NBC’s “Friends.” She won an Emmy Award for best lead actress in a comedy for the role, and she has been nominated for nine more. She currently stars in “The Morning Show” on Apple TV+.

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  • Judge Remains Undecided on Treatment Plan for Man Charged With Stalking Jennifer Aniston

    LOS ANGELES (AP) — A judge remained undecided Friday on the treatment and placement plan for a man charged with stalking Jennifer Aniston and ramming his car into the front gate of her home.

    Jimmy Wayne Carwyle, a 48-year-old from Mississippi, has pleaded not guilty to felony stalking and vandalism. But in May, Judge Maria Cavalluzzi found him not competent to stand trial after evaluations from two experts. At Friday’s hearing in a Los Angeles court dedicated to mental health cases, she heard arguments on Carwyle’s treatment and placement.

    Aniston’s lawyer, Blair Berk, spoke on her behalf for the first time, detailing two years of Carwyle’s harassment and stalking, including various failed attempts to make physical contact with the actor.

    Cavalluzzi said she leaned toward sending Carwyle to a mental health treatment alternative to imprisonment. She requested another hearing, scheduled for later this month, to hear from a mental health professional before making a final decision.

    Prosecutors and Aniston’s attorney will have a chance to weigh in, Cavalluzzi said.

    The judge acknowledged Aniston’s “very real” fear, but she said she can’t ignore the opinions of mental health professionals who have evaluated Carwyle and deemed him not a danger to society. The alternative treatment option offers community-based housing, treatment and support services as opposed to incarceration.


    Harassment started 2 years ago, prosecutors say

    Prosecutors alleged Carwyle had been harassing the “Friends” star with a flood of voicemail, email and social media messages for two years before driving his Chrysler PT Cruiser through the gate of her home in the wealthy Bel Air neighborhood of Los Angeles on May 5, “only feet away from where she was,” Berk said.

    Carwyle had a stated and “persistent delusion” to impregnate Aniston with three children, Berk said, and “there is simply no way to prevent him from carrying out his delusion if he walks out.”

    The prosecution expressed concern that if Carwyle were offered the treatment in Los Angeles, nothing would stop him “from traveling those few miles to Ms. Aniston,” Berk said.

    Berk and William Donovan, the deputy district attorney, argued Carwyle was a present danger to Aniston and those around her. Berk said he attempted to enter her property twice, but was turned away.

    Carwyle’s lawyer, Robert Krauss, said his client qualifies for alternative treatment, arguing that he hasn’t been convicted of violent crimes. Granting him alternative treatment, “is not like giving him a break or showing him leniency,” Krauss said. “Its just one thing and one thing only — and that is absolute, pure faithfulness of the law.”

    Krauss also referenced a report from the probation department, which recommended Carwyle be granted probation and 90 days in jail if convicted, much less than the over three years maximum sentence for his two charges. Carwyle has been in jail since May and, if convicted, could be let out with time served.


    Suspect says he won’t walk away from treatment

    Carwyle was present at the hearing and addressed questions from Cavalluzzi, saying he “wasn’t right in the head,” when asked about the text messages he sent Aniston. He said he has been taking medication, which is keeping him focused, and admitted his wrongdoing.

    When Cavalluzzi asked how she can be sure he won’t walk away from the treatment program — a stated concern from the prosecution — Carwyle responded, “You have my word.”

    Berk said Carwyle “traveled thousands of miles over a year ago “after sending thousands of messages” that reflected “his delusions and intentions to not just make contact with Ms. Aniston, but to commit criminal wrongs against her, sexual violence against her.” She added that Carwyle stressed in his messaging that he “would be unabated by doctors or others or FBI intervening.”

    Donovan argued that a state hospital is a “much safer, much more effective place for him to go,” and will offer the treatment Carwyle needs to address his delusions. The prosecution also argued there’s no evidence that Carwyle’s delusions toward Aniston have stopped, even with medication.

    Carwyle has been under involuntary medication for the past few months. Krauss said that Carwyle’s actions toward Aniston were “just the product of psychosis from someone who is unmedicated.” The government must keep its “promise of treatment rather than punishment and of rehabilitation rather than incarceration,” he said.

    The hearing was postponed several times in recent months as Carwyle at first objected to the incompetence finding and asked for an opinion, and both sides sought more time to examine the case.

    Carwyle remains jailed, but he is under a judge’s order not to contact or get near Aniston.

    Authorities said Aniston was home at the time of the gate crash, but he did not come into contact with her. A security guard stopped him in her driveway until police arrived. No one was injured.

    Carwyle also faces an aggravating circumstance of the threat of great bodily harm.

    Aniston became one of the biggest stars in television in her 10 years on NBC’s “Friends.” She won an Emmy Award for best lead actress in a comedy for the role, and she has been nominated for nine more. She currently stars in “The Morning Show” on Apple TV+.

    Copyright 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

    Photos You Should See – Sept. 2025

    Associated Press

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  • The Validity of SIBO Tests  | NutritionFacts.org

    Even if we could accurately diagnose small intestinal bacterial overgrowth (SIBO), if there is no difference in symptoms between those testing positive and those testing negative, what’s the point?

    Gastrointestinal symptoms like abdominal pain and bloating account for millions of doctor visits every year. One of the conditions that may be considered for such a “nonspecific presentation” of symptoms is SIBO, a concept that “has gained popularity on the internet in addition to certain clinical and research circles.” SIBO is “broadly defined as excessive bacteria in the small intestine” and typically treated with antibiotics, but “dispensing antibiotics to patients with the nonspecific, common symptoms associated with SIBO is not without risks,” such as the fostering of antibiotic resistance, the emergence of side effects, and the elimination of our good bacteria that could set us up for an invasion of bad bugs like C. diff—all for a condition that may not even be real.

    Even alternative medicine journals admit that SIBO is being overdiagnosed, creating “confusion and fear.” SIBO testing “is overused and overly relied upon. Diagnoses are often handed out quickly and without adequate substantiation. Patients can be indoctrinated into thinking SIBO is a chronic condition that can not be cleared and will require lifelong management. This is simply not true for most and is an example of the damage done by overzealousness.” “The ‘monster’ that we now perceive SIBO to be may be no more than a phantom.”

    The traditional method for a diagnosis was a small bowel aspiration, an invasive test where a long tube is snaked down the throat to take a sample and count the bugs down there, as you can see at 2:10 in my video Are Small Intestinal Bacterial Overgrowth (SIBO) Tests Valid?.

    This method has been almost entirely replaced with breath tests. Normally, a sugar called glucose is almost entirely absorbed in the small intestine, so it never makes it down to the colon. So, the presence of bacterial fermentation of that sugar suggests there are bacteria in the small intestine. Fermentation can be detected because the bacteria produce specific gases that get absorbed in our bloodstream before being exhaled from our lungs, which can then be detected with a breathalyzer-type machine.

    Previously, the sugar lactulose was used, but “lactulose breath tests do not reliably detect the overgrowth of bacteria,” so researchers switched to glucose. However, when glucose was finally put to the test, it didn’t work. The bacterial load in the small intestine was similar for those testing positive or negative, so that wasn’t a useful test either. It turns out that glucose can make it down to the colon after all.

    Researchers labeled the glucose dose with a tracer and found that nearly half of the positive results from glucose breath tests were false positives because individuals were just fermenting it down in their colon, where our bacteria are supposed to be. So, “patients who are incorrectly labeled with SIBO may be prescribed multiple courses of antibiotics” for a condition they don’t even have.

    Why do experts continue to recommend breath testing? Could it be because the “experts” were at a conference supported by a breath testing company, and most had personally received funds from SIBO testing or antibiotic companies?

    Even if we could properly diagnose SIBO, does it matter? For those with digestive symptoms, there is a massive range of positivity for SIBO from approximately 4 percent to 84 percent. Researchers “found there to be no difference in overall symptom scores between those testing positive against those testing negative for SIBO…” So, a positive test result could mean anything. Who cares if some people have bacteria growing in their small intestines if it doesn’t correlate with symptoms?

    Now, antibiotics can make people with irritable bowel-type symptoms who have been diagnosed with SIBO feel better. Does that prove SIBO was the cause? No, because antibiotics can make just as many people feel better who are negative for SIBO. Currently, the antibiotic rifaximin is most often used for SIBO, but it is “not currently FDA-approved for use in this indication, and its cost can be prohibitive.” (The FDA is the U.S. Food and Drug Administration.) In fact, no drug has been approved for SIBO in the United States or Europe, so even with good insurance, it may cost as much as $50 a day in out-of-pocket expenses, and the course is typically two weeks.

    What’s more, while antibiotics may help in the short term, they may make matters worse in the long term. Those “who are given a course of antibiotics are more than three times as likely to report more bowel symptoms 4 months later than controls.” So, what can we do for these kinds of symptoms? That’s exactly what I’m going to turn to next.

    Michael Greger M.D. FACLM

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  • Does Fasting Help Treat Depression?  | NutritionFacts.org

    Caloric restriction can boost levels of brain-derived neurotrophic factor (BDNF), which is considered to play a critical role in mood disorders.

    For more than a century, fasting has been espoused as a treatment of supposed “great utility in the preservation of health,” especially rejuvenating the body and, above all, the mind. When people fast for even 18 hours, though, they may get hungry and irritable. After one or two days, positive mood goes down and negative mood goes up, and after three days, fasters can increasingly feel sad, self-blame, and suffer a loss of libido. Then, something strange starts to happen: People experience a “fasting-induced mood enhancement…reflected by decreased anxiety, depression, fatigue, and improved vigor.” Studies tend to show this across the board. Once you get over the hump, fasters frequently experience “an increased level of vigilance and a mood improvement, a subjective feeling of well-being, and sometimes of euphoria.” And, no wonder, as, by then, endorphin levels may rise by nearly 50 percent, as seen here and at 1:06 in my video Friday Favorites: Fasting to Treat Depression

    This enhancement of mood, alertness, and calm makes a certain amount of evolutionary sense. Our body wants us to feel poorly initially so we continue to eat, day to day, when food is available, but if we go a couple of days without food, our body realizes we can’t just mope in our cave; we need to get motivated to go out and find some calories.

    So, can fasting be used for mood disorders, like depression? It’s great that people can feel better after a few days of fasting, but the critical question revolves around the “persistence of mood improvement over time” once fasting ends and eating resumes. The little published evidence we have comes out of Japan and the former Soviet Union, and some of it is just ridiculous, like this study that included women with a variety of symptoms, which the researchers blame mostly on marital conflict, as you can see below and at 2:08 in my video. Husband not treating you right? How about some “electroshock therapy”? That didn’t seem to help much, so what about “hunger therapy”? Of course, starving the women made them hungry, but that’s what Thorazine is for. If they keep getting injected with an antipsychotic to calm them down, they can sail right through. So, what happened in the study? What would we even do with those results? 

    Another study, however, skipped the Thorazine. The participants fasted for ten days, but they were also kept in bed all day on “absolute bed rest,” completely isolated and “prohibited from seeing other people except the attending doctor and nurse…also denied access to television, radio, newspapers or any other forms of information.” So, if people got better or worse, it would be impossible to tease out the effects of the fasting component on its own. But researchers found that they apparently did get better, with efficacy reportedly demonstrated in 31 out of 36 patients suffering from depression, as seen here and at 2:56 in my video.

    The researchers concluded that fasting therapy may provide an alternative to the use of antidepressant drugs, “thinking the fasting therapy may be a kind of shock therapy.” People are so relieved to be eating again, to get out of solitary confinement, and to even just get out of bed that they report feeling better. That was at the time of discharge, though. How did they feel the next day, the next week, the next month? Fasting is, by definition, unsustainable, so what we want to ideally see are some kind of longer-lasting effects.

    Researchers did a follow-up with a few hundred patients, not just a few months later, but after a few years. Of the 69 who were evidently suffering from depression, 90 percent reported feeling good or excellent results at the end of the ten-day fast, and, remarkably, years later, 87 percent of the 62 individuals who replied claimed that they were still doing well. Now, there was no control group, so we don’t know if they would have done just as well or even better without the fast, and it was all self-reporting, so there may have been a response bias where participants tried to please the researchers. Who knows? Maybe they were afraid they’d get sent back to solitary if they didn’t respond affirmatively. We have no idea, but we do have good evidence for the short-term mood benefits.

    Why would fasting improve feelings of depression? In addition to the endorphins and the surge in serotonin, the so-called happiness hormone, when we fast, there is a bump in brain-derived neurotrophic factor (BDNF), which is considered to play a crucial role in mood disorders. Researchers have perked up rodents with it, but we aren’t rats or mice. What about us? Humans with major depression have lower levels of BDNF circulating in their bloodstream. Autopsy studies of suicide victims show only about half the BDNF in certain key brain regions, compared to controls, suggesting it may play an important role in suicidal behavior, as seen here and at 4:38 in my video

    We can boost BDNF with antidepressant drugs and electroshock; we can also boost it with caloric restriction. We can get a 70 percent boost in levels after three months of cutting 25 percent of calories out of our daily diet, as shown below and at 4:51.

    Is there anything we can add to our diets to boost BNDF levels so we can get the benefits without the hunger? We’ll find out next.

    Michael Greger M.D. FACLM

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  • IBD and Cannabis  | NutritionFacts.org

    Smoking cannabis may help with symptoms of inflammatory bowel disease (IBD) in the short term, but it may make the long-term prognosis worse.

    As this study asks, “Medical Marijuana: A Panacea or Scourge?” For 5,000 years, cannabis “has been used throughout the world medically, recreationally, and spiritually.” It was even prescribed by American physicians “for a plethora of indications” from the mid-19th century to the 1930s, a fact that’s often used by medical marijuana proponents as evidence justifying the modern medical applications.” But the field of old-timey medicine is “fraught with potions and herbal remedies,” not to mention bloodletting and other questionable and harmful remedies.

    Skeptics criticize the medical marijuana movement as the “‘medical excuse marijuana’ movement,” insinuating that children with epilepsy and the terminally ill are being “used as a ‘Trojan horse’ for the legalization of recreational cannabis use” or to peddle “outlandish claims” about “miracle cancer cures,” frustrating researchers in the field who just want to get at the science.

    For example, what about the therapeutic use of cannabis for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis? Conventional therapies work mainly by suppressing the immune system to try to tamp down inflammation. “Given the limited therapy options and known adverse side effects with chronic use” from these drugs, people suffering from these diseases often need to have inflamed sections of their bowels removed surgically, so it’s clear why there’s so much interest in alternative approaches.

    About one in six IBD patients who use marijuana say it helps with their symptoms, so researchers decided to put it to the test. Thirteen patients with IBD were given a third of a pound of marijuana to smoke at their leisure over a period of three months, and they reported feeling significantly better with “reported improvement in general health perception, social functioning, ability to work, physical pain, and depression.” There wasn’t a control group, so it’s unknown if they would have improved anyway or what role the placebo effect may have played. It’s like some of the studies of cannabis used for pediatric epilepsy that had response rates exceeding 30 percent and a frequency cut in half in a third of the kids. Amazing results until you realize you can sometimes get similarly amazing responses from giving kids nothing but a sugar pill placebo, as seen below and at 2:21 in my video Friday Favorites: Cannabis for Inflammatory Bowel Disease (IBD). That’s why it’s critical to do randomized, double-blind, placebo-controlled trials, but there weren’t any on cannabis and IBD until 2013. 

    For 21 patients with Crohn’s disease, nothing seemed to help. So researchers randomized them to either smoke two joints a day of marijuana or a look-alike placebo. The results? Ninety percent of those in the cannabis group got better, compared to only 40 percent in the placebo group. Shown below and at 3:11 in my video is a graph of their symptom scores. As you can see, there was no big change in the placebo group over the two-month study, but the cannabis group cut their symptoms by about half. 

    The researchers acknowledge that long-term cannabis use is not without risks, but it may be a cakewalk compared to the potential adverse—and even life-threatening—side effects of some of the more powerful conventional therapies, so the study was heralded in a paper entitled “High Hope for Medical Marijuana in Digestive Disorders.”

    The study was funded by a medical marijuana advocacy organization, the main supplier in the country, in fact. So, expectations may have been placed on the participants about how much better they would feel—in other words, they may have been primed for the placebo effect. But the researchers controlled for that, right? Those getting the real cannabis did significantly better than those randomized to get the placebo. But the point of a placebo is that it is indistinguishable from the real thing, so the participants don’t know which group they’re in—the control group or the treatment group. How can that be accomplished with a psychoactive drug? It can’t, which is the problem. The researchers tried to hide which group participants were in by only recruiting patients who had never tried cannabis before in the hopes that they wouldn’t notice placebo pot, but, unsurprisingly, most of them did. So, we’re basically left with another unblinded study. The researchers asked a bunch of subjective questions, like “How are you feeling?” and those who pretty much knew they were taking the drug said they were feeling better.

    There were no significant changes in objective lab values, like CRP, a sign of inflammation, so perhaps the “cannabis may simply be masking symptoms without affecting intestinal inflammation.” Another indicator that it may not be affecting the course of the disease itself is how quickly the symptoms rebound. Two weeks after the study ended, those in the cannabis group were right back to where they started, as shown here (see week 10) and at 5:05 in my video

    So, “there was no difference in objective inflammatory markers to indicate disease modification. Given the rapid rebound…to pretreatment levels after the 2-week washout period, it seems more plausible that cannabis ameliorated the symptoms of Crohn’s disease, rather than actually modulating the disease.” That may be, but the symptoms are terrible. A reduction in pain is a reduction in pain. Indeed, “from the point of view of the patients, a marked symptomatic improvement and ability to resume normal life is not trivial, even if inflammation persists.” Of course, what if cannabis somehow makes the disease worse in the long run?

    A survey study published the following year found that cannabis provided the same immediate symptomatic relief but was associated with a worse disease prognosis over time. Patients with IBD reported that cannabis improved their pain, cramping, and diarrhea, but use for more than six months by Crohn’s patients appeared to be a strong predictor of them ending up in surgery; they had five times the odds of going under the knife. There are two possible explanations for this: It’s quite possible that the increased disease severity led to the cannabis use and not the other way around. The alternative explanation: “Cannabis use may worsen the prognosis of IBD, leading to greater surgeries and hospitalizations.”

    This is why we need prospective clinical trials where people are followed over time to see which came first. Until then, perhaps we should consider cannabis use for IBD as “potentially harmful.” Not just to err on the side of caution, but because there was a study on hepatitis C patients that found that daily cannabis use was associated with nearly seven times the odds of worse liver fibrosis, which is like scar tissue. If cannabis really does make fibrosis worse, that may explain why cannabis users with IBD may be more likely to require surgery. 

    Michael Greger M.D. FACLM

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  • What About Elderberry, Echinacea, and Cranberries for Colds and the Flu?  | NutritionFacts.org

    How effective are flu shots, elderberries, echinacea, and cranberries?

    The U.S. Centers for Disease Control and Prevention (CDC) recommends that everyone over the age of six months get a routine flu shot every year, unless you have some sort of contraindication, such as an allergy to any of the vaccine’s components. CDC recommends getting vaccinated by the end of October, but it may even be beneficial when received in December or later. How effective are flu vaccines? It depends on the year, but, as you can see below and at 0:33 in my video Friday Favorites: Elderberry Benefits and Side Effects: Does It Help with Colds and the Flu?, the flu vaccine typically reduces the risk of getting the flu by about 40 to 50 percent.

    So, in healthy adults, we can say with moderate certainty that we can decrease our risk of influenza from about 2 percent each year down to just under 1 percent. Older adults may get a similar relative risk reduction, but the baseline risk is higher and the consequences greater, so the absolute benefits are greater, too. In kids, flu vaccines shine; there’s a high certainty of evidence of a substantial drop in risk. But even in this kind of best-case scenario, there’s still a risk with vaccination, so what else can we do?

    In the United States alone, each year, Americans experience millions of cases of influenza and hundreds of millions of colds. What about elderberry supplements? In a test tube, elderberry extracts can inhibit pathogens, including the flu virus. In a petri dish, it can rev up the production of flu-fighting molecules from human immune system cells, like tumor necrosis factor, as much as nearly 45-fold. Elderberry juice can help mice fight off the flu. But what about actual people?

    The first clinical trial was published back in the 1990s: a double-blind, randomized, placebo-controlled trial to treat flu-like symptoms. Researchers found that the odds for improvement before the fifth day in those in the treated group were more than 20 times the odds of the participants in the control group (p < 0.001). Two subsequent double-blind, randomized, placebo-controlled trials showed similar accelerated healing in the elderberry groups, as you can see here and at 1:54 in my video

    I was excited to see this study—“Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travelers”—given a 200-city book tour I was embarking on. It was a randomized, double-blind, placebo-controlled clinical trial of 312 economy class passengers. While taking elderberry didn’t seem to prevent people from coming down with cold symptoms, the duration and severity of symptoms in those who did get a cold seemed to have been lessened, and they suffered an average of about five days instead of seven.

    A similar study using the herb echinacea found a lessening of symptom scores, but it was of only borderline statistical significance. Nevertheless, even though most of the individual trials didn’t find statistically significant improvements, when all such studies were compiled, it seems there may be about a 20 percent decrease incidence of colds, as seen below and at 2:50 in my video.

    Note, though, that there is a concern about publication bias and selective reporting. A number of findings and some entire studies seem to be MIA, suggesting that negative studies may have been quietly shelved. So, we aren’t really sure about echinacea, but all the elderberry studies seem to have positive results, suggesting elderberry supplementation “provides an effective treatment option when advanced or more invasive care [more serious treatment] is not warranted.” This conclusion came from someone with apparent conflicts of interest, though. In fact, each of the four elderberry studies was funded by the elderberry product companies themselves.

    Any other berries that might be helpful? A randomized, placebo-controlled, interventional study—funded, predictably, by Ocean Spray—found that the gamma-delta-T-cells of those drinking a low-calorie cranberry juice beverage for ten weeks appeared to be proliferating at nearly fivefold the rate. These immune cells “serve as a first line of defense.” Though the study participants didn’t get fewer colds, they did seem to suffer less, but not enough to prevent days missed from work or an impairment of their activities, as shown here and at 3:56 in my video

    At least cranberries have never been reported to cause pancreatitis. A man taking an elderberry extract not only suffered an attack of acute pancreatitis, a sudden painful inflammation of the pancreas, but it went away when he stopped it, then reappeared again years later when he tried taking it again, which suggests cause-and-effect. Why take elderberry extracts when you can just eat the elderberries themselves? Well, cooked are fine, but “consuming uncooked blue or black elderberries can cause nausea and vomiting.”

    I found out the hard way, as I explained in an answer to the question, “What was the worst day of your life?” in my London Real interview on my How Not to Die book tour. It turns out elderberry fruits form cyanide, such that eight people had to be medevacked out after someone brought freshly squeezed elderberry juice to a gathering.

    Doctor’s Note:

    Here’s the London Real interview I mentioned.

    What else can we do for the common cold? See the related posts below.

    And, speaking of cranberries, Can Cranberry Juice Treat Bladder Infections?. Watch the video to find out. 

    Michael Greger M.D. FACLM

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  • A King’s Breakfast, a Prince’s Lunch, and a Pauper’s Dinner  | NutritionFacts.org

    A King’s Breakfast, a Prince’s Lunch, and a Pauper’s Dinner  | NutritionFacts.org

    Harness the power of your circadian rhythms for weight loss by making breakfast or lunch your main meal of the day.

    In my last chronobiology video, we learned that calories eaten at breakfast are significantly less fattening than the same number of calories eaten at dinner, as you can see at 0:14 in my video Breakfast Like a King, Lunch Like a Prince, Dinner Like a Pauper, but who eats just one meal a day? 

    What about simply shifting our daily distribution of calories to earlier in the day? Israeli researchers randomized overweight and obese women into one of two isocaloric groups, meaning each group was given the same number of total calories. One group got a 700-calorie breakfast, a 500-calorie lunch, and a 200-calorie dinner, and the other group got the opposite—200 calories for breakfast, 500 for lunch, and 700 for dinner. Since all of the study participants were eating the same number of calories overall, the king-prince-pauper group should have lost the same amount of weight as the pauper-prince-king group, right? But, no. As you can see in the graph below and at 1:01 in my video, the bigger breakfast group lost more than twice as much weight, in addition to slimming about an extra two inches off their waistline. By the end of the 12-week study, the king-prince-pauper group lost 11 more pounds than the bigger dinner group, dropping 19 pounds compared to only 8 pounds lost by the pauper-prince-king group—despite eating the same number of calories. That’s the power of chronobiology, the power of our circadian rhythm. 

    What was the caloric distribution of the king-prince-pauper group getting 700 calories at breakfast, 500 at lunch, and 200 at dinner? They got 50 percent of calories at breakfast, 36 percent at lunch, and only 14 percent of calories at dinner, which is pretty skewed. What about 20 percent for dinner instead? A 50% – 30% – 20% spread, compared to 20% – 30% – 50%?

    Again, the bigger breakfast group experienced “dramatically increased” weight loss, a difference of about nine pounds in eight weeks with no significant difference in overall caloric intake or physical activity between the groups, as shown in the graph below and at 1:57 in my video

    Instead of 80 percent of calories consumed at breakfast and lunch, what about 70 percent compared to 55 percent? Researchers randomized overweight “homemakers” to eat 70 percent of their calories at breakfast, a morning snack, and lunch, leaving 30 percent for an afternoon snack and dinner, or a more balanced 55 percent from the time they woke up through lunch. In both cases, only a minority of calories were eaten for dinner, as you can see below, and at 2:25 in my video. Was there any difference between eating 70 percent of calories through lunch versus only 55 percent? Yes, those eating more calories earlier in the day had significantly more weight loss and slimming. 

    Concluded the researchers: “Stories about food and nutrition are in the news on an almost daily basis, but information can sometimes be confusing and contradictory. Clear messages should be proposed to reach the greatest number of people. One clear communication from physicians could be ‘If you want to lose weight, eat more in the morning than in the evening.’” 

    Even just telling people to eat their main meal at lunch rather than dinner may help. Despite comparable caloric intakes, participants in a weight-loss program randomized to get advice to make lunch their main meal beat out those who instead were told to make dinner their main meal.

    The proverb “Eat breakfast like a king, lunch like a prince, and dinner like a pauper” evidently has another variant: “Eat breakfast yourself, share lunch with a friend, and give dinner away to your enemy.” I wouldn’t go that far, but there does appear to be a metabolic benefit to frontloading the bulk of your calories earlier in the day.

    The evidence isn’t completely consistent, though. A review of dietary pattern studies questioned whether reducing evening intake would facilitate weight loss, citing a study that showed the evening-weighted group did better than the heavy-morning-meal group. Perhaps that was because the morning meal group was given “chocolate, cookies, cake, ice cream, chocolate mousse or donuts” for breakfast. So, chronobiology can be trumped by a junk-food methodology. Overall, the what is still more important than the when. Caloric timing may be used to accelerate weight loss, but it doesn’t substitute for a healthy diet. When he said there was a time for every purpose under heaven, Ecclesiastes probably wasn’t talking about donuts.

    When I heard about this, what I wanted to know was how. Why does our body store less food as fat in the morning? I explore the mechanism in my next video, Eat More Calories in the Morning Than the Evening.

    This is the fifth video in an 11-part series on chronobiology. If you missed the first four, check out the related posts below. 

    Michael Greger M.D. FACLM

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  • How to Make a “Medicine Ball,” Starbucks’s Slightly Controversial Tea Drink – POPSUGAR Australia

    How to Make a “Medicine Ball,” Starbucks’s Slightly Controversial Tea Drink – POPSUGAR Australia

    When you’re searching for relief from the discomfort of a cold or the flu, you likely hit up the drugstore’s cold and flu aisle. But at least some people also swing by their local Starbucks for a semi-controversial, cult-favorite drink. Yes, we’re talking about the Starbucks “Medicine Ball,” a soothing tea blend that has garnered a loyal following for its comforting effects.

    We’re believers that the best forms of relief come from the most unexpected places, and that anything that offers a glimmer of comfort amidst the discomfort of sickness is worth its weight in gold. The only problem with the Starbucks Medicine Ball drink is that you have to leave your house to get it – and, if you’re drinking it because you’re not feeling well, that means potentially exposing the hard-working baristas to your germs. With that in mind, we pulled together a Starbucks Medicine Ball recipe, to help you recreate the soothing comfort in the safety of your own home.

    What’s In a Starbucks Medicine Ball?

    Firstly, it’s crucial to point out that the Starbucks Medicine Ball does not contain actual medicine. At Starbucks, the drink is officially known as Honey Citrus Mint Tea. The menu states it was a popular customer creation that ended up on the regular menu. The soothing beverage combines Jade Citrus Mint green tea, Peach Tranquility herbal tea (a tea made with sweet peach, pineapple, chamomile blossoms, and lemon verbena), hot water, steamed lemonade, and honey.

    This drink does contain a small amount of caffeine, as it is made with a green tea which naturally contains this stimulant. But the overall caffeine level of this drink is relatively low compared to other Starbucks beverages, making it a comforting choice for those looking for a warm, soothing option with a hint of a caffeine pick-me-up.

    And while, again, the Starbucks Medicine Ball does not contain any true medicine, some people find that consuming honey helps ease their sore throat somewhat, while mint may help clear congestion temporarily.

    How To Order the Starbucks “Medicine Ball” Drink

    To order a Medicine Ball at Starbucks, simply approach the counter and ask for a Honey Citrus Mint Tea, the drink’s official name. If desired, you can customize your tea drink by asking for more or less lemonade and/or honey if you want it sweeter or not-as-sweet.

    A word of warning: some baristas aren’t huge fans of the Starbucks Medicine Ball, as evidenced by several Reddit threads like this one. The main complaint seems to be its popularity among sick people, who put baristas’ health at risk by coming into stores in person to order the drink. So keep in mind that if you are sick and contagious, you may not be considered the kindest patron if you’re prancing into a crowded Starbucks store, sniffling and sneezing – potentially exposing other customers to your illness. If you’re sick and you want to enjoy this drink, send a friend to snag one for you, hit up the drive-through (while wearing a mask), or make our Starbucks Medicine Ball recipe at home instead.

    Related: Is It Rude to Lie About Being Sick? And 21 Other Illness Etiquette Questions

    Starbucks Medicine Ball Tea Recipe

    To recreate the soothing Starbucks Medicine Ball tea at home, you’ll need the following ingredients:

    • 1 bag of Teavana Jade Citrus Mint Green Tea
    • 1 bag of Teavana Peach Tranquility Herbal Tea
    • 8 ounces of hot water
    • 8 ounces of steamed lemonade
    • 1 tablespoon of honey

    Steps:

    1. Heat your water to a near-boil and pour 8 ounces into a mug.
    2. Add both tea bags to the mug and allow them to steep for about 3-5 minutes.
    3. While the tea is steeping, heat your lemonade. You can do this by either heating it on the stove or by using a microwave. Aim for it to be hot but not boiling.
    4. Remove the tea bags from the mug, ensuring to squeeze them gently to extract the flavorful tea without releasing bitterness.
    5. Add the hot lemonade to your mug with the steeped tea.
    6. Stir in a tablespoon of honey, adjusting according to your sweetness preference.
    7. Enjoy your homemade Starbucks Medicine Ball, perfect for soothing a sore throat or just warming up on a chilly day.

    If you don’t have access to Teavana teas, you can use other brands of green tea, mint tea, and peach tea to recreate this concoction. And if you don’t have lemonade on hand, a healthy squeeze of lemon juice can do in a pinch, although you may need to increase the amount of water and honey you use to compensate.

    Then, sip and enjoy the soothing sensation. Ahhh…


    Lauren Manaker is an award-winning registered dietitian and freelance writer who is passionate about providing evidence-based nutrition information in a fun and interesting way.


    Lauren manaker

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  • Stay informed on women’s health issues in the Women’s Helth channel

    Stay informed on women’s health issues in the Women’s Helth channel

    According to a recently published article on Axios, women have higher out-of-pocket expenses for their health care than men despite having similar health insurance. Even when removing maternity care from the equation, women each year are paying $15.4 billion more out of pocket for health care. This so-called ‘Pink tax’ reflects the penalty levied on females for everything from tampons and razors—is alive and well in the U.S. healthcare system. Below are some of the latest headlines in the Women’s Health channel on Newswise. 

    A New AI Model Has Been Developed to Improve Accuracy of Breast Cancer Tumor Removal

    -University of North Carolina School of Medicine

    Social media and low self-compassion behind rise in cosmetic surgery

    -University of South Australia

    Exposure to extreme heat associated with adverse health outcomes for pregnant women

    -University of California, Irvine

    Iron supplements provided in prenatal visits improved outcomes

    -UT Southwestern Medical Center

    Study finds the placenta holds answers to many unexplained pregnancy losses

    -Yale University

    Witchcraft accusations an ‘occupational hazard’ for female workers in early modern England

    -University of Cambridge

    Substance Abuse in Pregnancy Doubles Cardiovascular Risk

    -Cedars-Sinai

    In major breakthrough, researchers close in on preeclampsia cure

    -University of Western Ontario (now Western University)

    When it comes to starting a family, timing is everything

    -University of Oxford

    Using personalized medicine to target gynecological cancers

    -University of California, Los Angeles (UCLA), Health Sciences

    Internet searches increased for self-managed abortions when Roe vs. Wade was overturned

    -University of California, Irvine

    Stem cell-derived components may treat underlying causes of PCOS

    -University of Chicago Medical Center

    High levels of particulate air pollution associated with increased breast cancer incidence

    -National Institute of Environmental Health Sciences (NIEHS)

     

    Newswise

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  • Tribal courts across the country are expanding holistic alternatives to the criminal justice system

    Tribal courts across the country are expanding holistic alternatives to the criminal justice system

    Inside a jail cell at Laguna Pueblo in New Mexico, Albertyn Pino’s only plan was to finish the six-month sentence for public intoxication, along with other charges, and to return to her abusive boyfriend.

    That’s when she was offered a lifeline: An invitation to the tribe’s Healing to Wellness Court. She would be released early if she agreed to attend alcohol treatment and counseling sessions, secure a bed at a shelter, get a job, undergo drug testing and regularly check in with a judge.

    Pino, now 53, ultimately completed the requirements and, after about a year and a half, the charges were dropped. She looks back at that time, 15 years ago, and is grateful that people envisioned a better future for her when she struggled to see one for herself.

    “It helped me start learning more about myself, about what made me tick, because I didn’t know who I was,” said Pino, who is now a case manager and certified peer support worker. “I didn’t know what to do.”

    The concept of treating people in the criminal justice system holistically is not new in Indian Country, but there are new programs coming on board as well as expanded approaches. About one-third of the roughly 320 tribal court systems across the country have aspects of this healing and wellness approach, according to the National American Indian Court Judges Association.

    Some tribes are incorporating these aspects into more specialized juvenile and family courts, said Kristina Pacheco, Tribal Healing to Wellness Court specialist for the California-based Tribal Law and Policy Institute. The court judges association is also working on pilot projects for holistic defense — which combine legal advocacy and support — with tribes in Alaska, Nevada and Oklahoma, modeled after a successful initiative at the Confederated Salish and Kootenai Tribes in Montana.

    “The thought and the concept will be different from tribe to tribe,” said Pacheco. “But ultimately, we all want our tribal people … to not hurt, not suffer.”

    People in the program typically are facing nonviolent misdemeanors, such as a DUI, public intoxication or burglary, she said. Some courts, like in the case of Pino, drop the charges once participants complete the program.

    A program at the Port Gamble S’Klallam Tribe in Washington state applies restorative principles, and assigns wellness coaches to serve Native Americans and non-Natives in the local county jail, a report released earlier this year by the John D. and Catherine T. MacArthur Foundation outlined. The Muscogee (Creek) Nation in Oklahoma has a reintegration program that includes financial support and housing services, as well as cultural programming, career development and legal counsel. In Alaska, the Kenaitze Indian Tribe’s wellness court helps adults in tribal and state court who are battling substance abuse and incorporates elements of their tribe’s culture.

    “There’s a lot of shame and guilt when you’re arrested,” said Mary Rodriguez, staff attorney for the court judges association. “You don’t reach out to those resources, you feel that you aren’t entitled to those resources, that those are for somebody who isn’t in trouble with the law.”

    “The idea of holistic defense is opening that up and reclaiming you are our community member, we understand there are issues,” Rodriguez said. “You are better than the worst thing you’ve done.”

    The MacArthur Foundation report outlined a series of inequities, including a complicated jurisdictional maze in Indian Country that can result in multiple courts charging Native Americans for the same offense. The report also listed historical trauma and a lack of access to free, legal counsel within tribes as factors that contribute to disproportionate representation of Native Americans in federal and state prisons.

    Advocates of tribal healing to wellness initiatives see the approaches as a way to shift the narrative of someone’s life and address the underlying causes of criminal activity.

    There isn’t clear data that shows how holistic alternatives to harsh penalization have influenced incarceration rates. Narrative outcomes might be a better measure of success, including regaining custody of one’s children and maintaining a driver’s license, said Johanna Farmer, an enrolled citizen of the Rosebud Sioux Tribe in South Dakota and a program attorney for the court judges association.

    Some tribes have incorporated specific cultural and community elements into healing, such as requiring participants to interview their own family members to establish a sense of rootedness and belonging.

    “You have the narratives, the stories, the qualitative data showing that healing to wellness court, the holistic defense practices are more in line with a lot of traditional tribal community practices,” Farmer said. “And when your justice systems align with your traditional values or the values you have in your community, the more likely you’re going to see better results.”

    While not all of these tribal healing to wellness programs have received federal funding, some have.

    Between 2020 and 2022, the U.S. Department of Justice distributed more than a dozen awards that totaled about $9.4 million for tribal healing to wellness courts.

    This year, the Quapaw Nation in Oklahoma started working on a holistic defense program after seeing a sharp increase in cases following a U.S. Supreme Court ruling that said a large area of eastern Oklahoma remains a Native American reservation.

    So far this year, about 70 cases have been filed, up from nearly a dozen in all of 2020, said Corissa Millard, tribal court administrator.

    “When we look at holistic approaches, we think, what’s going to better help the community in long term?” she said. “Is sending someone away for a three-year punishment going to be it? Will they reoffend once they get out? Or do you want to try to fix the problem before it escalates?”

    For Pino, the journey through Laguna Pueblo’s wellness court wasn’t smooth. She struggled through relapses and a brief stint on the run before she found a job and an apartment to live in with her son nearby in Albuquerque, New Mexico. Her daughters live close by.

    She largely credits the wellness court staff for her ability to turnaround her life, she said.

    “They were the ones that stood by me, regardless of what I was choosing to do; that was the part that brought me a lot of hope,” she said. “And now where I’m at, just to see them happy, it gets emotional, because they never let go. They never gave up on me.” ___

    Associated Press writer Felicia Fonseca in Flagstaff, Arizona, contributed.

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  • Oath Keepers convicted in Jan. 6 Capitol riot get prison in latest extremist sentencings

    Oath Keepers convicted in Jan. 6 Capitol riot get prison in latest extremist sentencings

    WASHINGTON — Two Florida men who stormed the U.S. Capitol with other members of the far-right Oath Keepers group were sentenced Friday to three years in prison for seditious conspiracy and other charges — the latest in a historic string of sentences in the Jan. 6. 2021 attack.

    David Moerschel, 45, a neurophysiologist from Punta Gorda, and Joseph Hackett, a 52-year-old chiropractor from Sarasota, were convicted in January alongside other members of the antigovernment extremist group for their roles in what prosecutors described as a violent plot to stop the transfer power from former President Donald Trump to President Joe Biden after the 2020 election.

    Both men were among the lower-level members charged with seditious conspiracy. Moerschel was sentenced to three years in prison and Hackett got three and a half years.

    All told, nine people associated with the Oath Keepers have been tried for seditious conspiracy and six were convicted of the rarely used Civil War-era charge in two separate trials, including the group’s founder Stewart Rhodes. Rhodes was sentenced last week to 18 years in prison — a record for a Jan. 6 defendant. Three defendants were cleared of the sedition charge but found guilty of other Jan. 6 crimes.

    Moerschel and Hackett helped amass guns and ammunition to stash in a Virginia hotel for a so-called “quick reaction force” that could be quickly shuttled to Washington, prosecutors said. The weapons were never deployed. Moerschel provided an AR-15 and a Glock semi-automatic handgun and Hackett helped transport weapons, prosecutors said.

    On Jan. 6, both men dressed in paramilitary gear and marched into the Capitol with fellow Oath Keepers in a military-style line formation, charging documents stated.

    “The security of our country and the safety of democracy should not hinge on the impulses of madmen,” Justice Department prosecutor Troy Edwards said.

    Moerschel told the judge he was deeply ashamed of forcing his way into the Capitol and joining the riot that seriously injured police officers and sent staffers running in fear.

    “When I was on the stairs, your honor, I felt like God said to me, ‘Get out here.’ And I didn’t,” he said in court, his voice cracking with emotion. “I disobeyed God and I broke laws.”

    Moerschel was a neurophysiologist who monitored surgical patients under anesthesia before his arrest, though he’s since been fired and now works in construction and landscaping. A former missionary, he is married with three children.

    Hackett similarly said he remembered feeling horrified as stepped foot in the Capitol that day: “I truly am sorry for my part in causing so much misery,” he said.

    He originally joined the group after seeing vandalism at a commercial area near his house during the summer of 2020, when protests against police brutality were common, his attorney Angela Halim said. “He did not join this organization because he shared any beliefs of Stewart Rhodes,” she said.

    Still, he later attended an “unconventional warfare” training, and in the leadup to Jan. 6 he repeatedly warned other Oath Keepers about “leaks” and the need to secure their communications, and later changed his online screen names, authorities have said.

    “Taken together, his messages show he perceived the election as an existential threat,” said prosecutor Alexandra Hughes.

    How the chiropractor and father ended up storming the Capitol, though, is “hard to wrap one’s head around,” said U.S. District Judge Amit Mehta. The group’s increasingly heated online conversations and false claims of a stolen election “can suck you in like a vortex make and make it very difficult to get out.”

    Neither man was a top leader in the group, and both left shortly after Jan. 6. Both sentences were far lower than the 12 years prosecutors sought for Hackett and 10 for Moreschel.

    Moreschel was in the Capitol for about 12 minutes, and didn’t do anything violent or scream at police officers, Mehta noted. He also handed his guns over to police.

    “Sentencing shouldn’t be vengeful, it shouldn’t be such that it is unduly harsh simply for the sake of being harsh,” said the judge, who also imposed a three-year term of supervised release for both men.

    Moerschel’s attorneys had asked for home confinement, arguing that he joined the Oath Keepers chats shortly before the riot and was not a leader.

    “He was just in the back following the crowd,” attorney Scott Weinberg told the judge.

    Defense attorneys have long said there was never a plan to attack the Capitol and prosecutors’ case was largely built on online messages cherry-picked out of context.

    The charges against leaders of the Oath Keepers and another far-right extremist group, the Proud Boys, are among the most serious brought in the Justice Department’s sprawling riot investigation. Prosecutors have also won seditious conspiracy convictions in the case against former Proud Boys national chairman Enrique Tarrio and three other group leaders in what prosecutors said was a separate plot to keep Trump in the White House.

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  • Music Therapy: Relief for Chronic Pain Sufferers

    Music Therapy: Relief for Chronic Pain Sufferers

    Newswise — In Sörmland, Sweden, music therapy is offered as a method of treatment for people living with chronic pain. Currently, the effects of what is known as the FMT method are being investigated through a research project at Mälardalen University (MDU).

    In the FMT method, (Functionally oriented Music Therapy), music experiences and movement are combined with the purpose of contributing to a person’s well-being and recuperation. During the treatment, a therapist assesses what basic functions the participant needs to develop, and with the help of musical instruments such as drums and cymbals in various formations, different movements in the body are stimulated. Today, the treatment is given through a healthcare agreement in Sörmland.

    In a current research project which has been launched at MDU, researchers wish to investigate whether it is possible to find scientific evidence that the FMT method is effective in increasing well-being, improving quality of life, and if and in what way it can relieve suffering and pain in people who live with chronic pain.

    “I believe it is essential to evaluate health-promoting alternative methods in the area of chronic pain, as many people in society suffer from this. This project aims to explore and evaluate an up until now unexplored treatment method for people living with long standing pain,” says Helena Lööf, Associate Professor and Senior Lecturer in Health Sciences at MDU.

    The method contributed to recovery
    The backdrop to the project is a pilot study which showed that the FMT method helped people affected by stroke and Parkinson’s disease to recover better.

    “Pain is the most common reason for seeking primary care services. Therefore in this way, many people are affected and from a societal standpoint it is good to have a variety of support efforts. This is in line with person-centred healthcare.”

    Scientific evaluation needed
    “Through a care agreement with a FMT treatment centre in Eskilstuna, this method is already being used in primary care in Sörmland. But the method is not evidence-based, which is why a scientific evaluation is needed. We will evaluate the effects of FMT in people suffering from chronic pain in comparison with the standard care that is provided in local healthcare. We also wish to create a deeper understanding of the importance of music and movement in recovery.”

    Today, FMT is used in habilitation, rehabilitation and psychiatric healthcare.

    “If the results of the project are positive, that is, if evidence can be found that various aspects of health are affected or improved, these can be used as evidence-based support for health promotion purposes for people suffering with chronic pain.”

    “And on the other hand, if the results show that FMT has no or only a minor effect, this is in itself an important contribution to new knowledge about treatment and recovery for these people. Our research team is looking forward to investigating this over the next few years,” says Helena Lööf.

    Malardalen University

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  • Illegal trade and poor regulation threaten pangolins in China

    Illegal trade and poor regulation threaten pangolins in China

    Newswise — Pangolins, unique scale-covered mammals, are drastically declining in numbers across Asia and Africa, largely due to illegal trade. Part of the trade, both legal and illegal, supports the traditional Chinese medicine market, which has attracted conservation attention. The level of demand for pangolins and other animals in traditional Chinese medicine, however, hasn’t been thoroughly studied.

    In a new study published in the journal Nature Conservation, Dr Yifu Wang, currently a postdoc researcher at the University of Hong Kong, investigated pangolin scale trade in China, interviewing staff in hospitals and pharmaceutical shops in two provinces (Henan and Hainan). Between October 2016 and April 2017, she and her team talked to doctors from 41 hospitals and shop owners and assistants from 134 pharmaceutical shops.

    The research found pangolin scales and their derivatives were widely available in hospitals and pharmaceutical shops across Henan and Hainan Provinces. The legislation in place, however, has not been able to prevent ongoing illegal trade in pangolin products. Her team found that 46% of surveyed hospitals and 34% of surveyed pharmaceutical shops were selling pangolin scale products illegally.

    “Existing legal trade allows 711 hospitals to sell pangolin products as medicine with regulations on manufacturer, package, and national annual sale quantity,” explains Dr Yifu Wang. “However, we show that pangolin scales are under heavy demand and unpermitted sellers are commonly found illegally selling pangolin products.”

    “Quantities of products traded by permitted legal sellers are estimated to greatly exceed the supply capacity of legal sources,” she continues.

    This widespread illegal trade, coupled with the very limited legal supply capacity compared to market demand, is concerning. The researchers point to the urgent need to reduce demand from traditional Chinese medicine on pangolin scales and revise the current legal pangolin scale trade system.

    “We also highlight the importance of incorporating the traditional Chinese medicine sector into combating illegal wildlife trade and species conservation beyond pangolins,” they conclude.

    The researchers plan to continue investigating the pangolin scale market in China to understand the trade after COVID-19.

     

    Original source:

    Wang Y, Turvey ST, Leader-Williams N (2023) The scale of the problem: understanding the demand for medicinal pangolin products in China. Nature Conservation 52: 47-61. https://doi.org/10.3897/natureconservation.52.95916

    Pensoft Publishers

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  • Learning to love music

    Learning to love music

    Newswise — In an inviting space full of vibrant bold colors, fiber optic curtains, and a vibrating haptic chair, sounds of “Row Row Row Your Boat” and other popular children’s songs fill the air, and children with autism are becoming their own composers, learning to love music. 

    This is the scene in the Sensory Room at the Route 9 Library and Innovation Center, where the music is theirs to alter as they see fit. When children like what they hear, they pause to listen more closely, smile, or dance. Other children focus intently as they explore the many combinations of sound available at their fingertips. Some young listeners take delight in adding a drumbeat or fast countermelody while others seem to prefer a calmer rendition of a familiar tune. As they listen, these children learn what they like to listen to and what they don’t, providing a valuable glimpse into how they respond to musical sounds. 

    The children are piloting a listening device developed by University of Delaware researchers Daniel Stevens, a professor of music theory in the School of Music within the College of Arts and SciencesMatthew Mauriello, assistant professor of computer and information sciences in the College of Engineering, and their respective students.

    The professors’ divergent backgrounds were a complementary match for this innovative project that aims to better the lives of children with developmental disabilities. Together, they applied for and were awarded $50,000 from the Maggie E. Neumann Health Sciences Research Fund to advance their research. The fund specifically targets interdisciplinary research and innovation that aims to improve the lives of people with disabilities.

    The device is the dream of sophomore Elise Ruggiero, a double major in music performance and psychology. Her younger brother was diagnosed with autism at age 2. 

    “I started playing violin at age 9. As I advanced in the music field and had recitals, I noticed that sitting still and listening to music was a challenge for my brother,” Ruggiero said. “When we’d go out to eat, if the restaurant was playing music too loudly, it would make him extremely anxious, and there wasn’t much we could do about it.” 

    In a freshman honors music theory class, Stevens tasked his students with solving a problem in the community. 

    “I asked students: ‘How would you like to change the world in which you live and work with your music skills?’ My challenge was met with stunned silence,” Stevens recalled.

    But students quickly got to work, reaching out to local organizations, identifying issues, and dreaming up ways to solve problems. Ruggiero used her personal experience to team up with Autism Delaware, and her idea to create an interactive music device for children with autism was ultimately selected to move forward as the class project.

    “It was really satisfying knowing that something I knew was a problem I wanted to tackle for so long is achievable,” Ruggiero said. “Seeing other people who are passionate about it too made me realize that together we can make a difference.” 

    Music theory students in Stevens’ class spent hours designing various renditions of what the team has been describing as modular music that’s modifiable to suit a child’s listening needs and preferences. 

    “Listeners with autism have real needs. Those with auditory sensitivities, for example, may be unable to participate in the formative experiences that children have singing songs with their parents or classmates, in part, because the music might be too fast, or it might have too much stimulation, or it might not have enough stimulation,” Stevens said. “Every child with autism is different, so we need to compose music that would address various needs.”

    Had a device like this existed years ago, Ruggiero said it could have helped her brother.

    “He was turned off by the idea of making music at a young age because he was so sensitive to sound,” Ruggiero said. “For other kids with autism, I want them to have the option to want to make music.”

    Mauriello joined the project shortly after its inception to help design, build and deploy the technology in the field. He’s passionate about applying computing to challenges related to social good using his background in human-computer interaction, a blend of computer science and engineering, design, and psychology. 

    “I enjoy opportunities to understand and empathize with users. This allows me to build technologies that meet their specific needs,” Mauriello said. 

    With generous support from the Maggie E. Neumann Health Sciences Research Fund, the researchers transformed an idea into a prototype. Now, a controller housed inside a white 3D-printed box with a series of presets, or light-up buttons with pictures of instruments provides a potentially infinite amount of sound combinations and aims to enhance the listening experience for children with autism. Every time a child presses a button, the sound or melody changes, sometimes slightly, other times dramatically; each interaction is recorded so Stevens and Mauriello can gather data about listening preferences and find new ways to display this data back to composers to help them create more suitable music. 

    “We want to understand the way children with autism hear the world and interact with music by looking at the larger patterns that start to emerge in the data,” Stevens said. “Music is such a rich artform, and yet we hear it so frequently, we take for granted melody, harmony, texture, rhythm and all these elements that work together to make every listening experience enjoyable. When it comes to listeners with autism, every sound is up for grabs. It’s been really rewarding to think about how music can serve the listener. The needs of this particular group of listeners invite us to think creatively about how sounds can be manipulated and designed to meet their needs.” 

    That’s an area of particular interest to Simon Brugel. The sophomore computer science major, who’s on the spectrum, brings personal experience to the project. He said he is sensitive to loud noises. 

    “I don’t like squeaking or alarms,” Brugel said. “I can notice some subtle sounds others might not notice, and I prefer some instruments over others.” 

    Brugel helped design and write the software for the prototype and never expected to work on a project with potential for broad impact this early in his college career.  

    “It’s satisfying to know that my creations are having an impact on the community or the advancement of research,” Brugel said. 

    By participating in this interdisciplinary research, Mauriello wants his students to understand that computing technology can serve diverse populations. 

    “To help broaden participation in computing, we need to demonstrate that computing can have an impact on diverse problems that are facing society,” Mauriello said. “This project offers a nice opportunity for that as computer science and engineering students work with music students to build something that can have a real impact on the world.” 

    Abby Von Ohlen, a sophomore music education major, loved playing a role in this project and watching the idea blossom.  

    “Seeing this idea come to fruition has been such a good experience,” Von Ohlen said. “I’ve always been able to enjoy music and not be overstimulated by it. It’s interesting to see that even just changing one track or sound level can affect someone. It’s fulfilling to know that others will be able to enjoy music as much as I do.” 

    Ruggiero has observed initial trials for the device and said feedback has shown the device can be engaging and might be more attractive to children if it looked more like a toy. 

    “A parent of one of the children suggested that he might enjoy the device more if it was shaped like a fire truck that they could wheel around while listening to music,” Ruggiero said. “If it was more physically appealing, it might make kids more inclined to play with it.” 

    For older children, Ruggiero envisions an app being useful. 

    “If a teen or adult is out in public and something bothers them, they can modify it or use their own music on their phone to calm themselves, I would love that,” she said. 

    Through working on this project, Ruggiero got a lot more than she ever dreamed of in her first year of college. She had simply hoped to meet new friends and become well-adjusted to college life.  

    “I was not expecting to have my idea go as far as it’s gone. It makes me so happy and excited,” she said.

    Now, she’s dreaming of a career in music therapy.

    “This project made me interested in the research aspects of music and psychology,” she said. “I want to work with people on the spectrum and make music more accessible to them.” 

    Ultimately, Mauriello and Stevens said they hope the music listening device becomes a permanent fixture in the Route 9 Library’s sensory room. They also hope to incorporate the device in music and special education classes.  

    “The research is very clear — music participation is incredibly important to a child’s social and emotional formation, their motor development, and their interactions with family members, other children and their community,” Stevens said. “We’re inspired to make formative, engaging, participatory musical experiences accessible to every child with autism in our state and beyond over time.”

    For more information on the project, . 

    About the fund

    Maggie E. Neumann Health Sciences Research Fund was established in 2020 to support research designed to improve health and quality of life outcomes for children and adults with physical and developmental disabilities. While the fund resides at the College of Health Sciences, the intent is to support interdisciplinary research across all colleges.

    The research fund was created with a gift from Donald J. Puglisi and Marichu C. Valencia in honor of their granddaughter, Maggie E. Neumann. Puglisi is a member of UD’s Board of Trustees and they both serve on the President’s Leadership Council.

    University of Delaware

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  • Saint Louis University’s Cannabis Science Certificate Wins Outstanding Program Award

    Saint Louis University’s Cannabis Science Certificate Wins Outstanding Program Award

    Newswise — ST. LOUIS – Saint Louis University’s Cannabis Science and Operations Certificate program was named the 2023 Outstanding Program by the University Professional and Continuing Education Association (UPCEA). The award recognizes outstanding professional and continuing education programs allowing students to earn academic credit.

    The honor was awarded during UPCEA’s annual conference this week.

    Launched in the fall of 2020 in SLU’s School for Professional Studies, the Cannabis Science and Operations Certificate is the most successful program in SPS’s history. Just three years after its launch, the program has 300 students and more than 140 graduates.

    SLU’s program was the first of its kind in St. Louis. Courses are taught by industry professionals and address all aspects of cannabis operations, including:

    • The fundamentals of growing, manufacturing and dispensing cannabis
    • Plant science and cultivation
    • Cannabis extraction and product production
    • Compliance and dispensary operations
    • Pharmacological properties of cannabis

    The 16-hour certificate program culminates with a research project.

    “While this program is 100% online, there are hands-on opportunities in each course that are successfully preparing our students to work in every aspect of the cannabis industry, providing well-rounded employees,” said program director Stacy Godlewski.

    Because the program instructors are all industry experts students have opportunities to network nationally with insiders across a variety of fields.

    “A high percentage of students are receiving job offers and reporting higher salaries due to the fact that they are enrolled in this program,” Godlewski said.

    Graduates from the program have found positions in cannabis sales, marketing, dispensary management, quality assurance and laboratory technology.

    In January 2022, the School for Professional Studies added a Medical Cannabis Science and Therapeutic Management Certificate. The Medical Cannabis Science and Therapeutic Management program is aimed at people who care for others by providing science-based education on cannabis-based therapy options.

    UPCEA is a leader in online and professional continuing education.

    About UPCEA

    UPCEA is the leading association for online and professional continuing education. Founded in 1915, UPCEA now serves the leading public and private colleges and universities in North America. The association supports its members with innovative conferences and specialty seminars, research and benchmarking information, professional networking opportunities and timely publications. Based in Washington, D.C., UPCEA builds greater awareness of the vital link between adult learners and public policy issues. Learn more at upcea.edu.

    About Saint Louis University

    Founded in 1818, Saint Louis University is one of the nation’s oldest and most prestigious Catholic institutions. Rooted in Jesuit values and its pioneering history as the first university west of the Mississippi River, SLU offers more than 13,500 students a rigorous, transformative education of the whole person. At the core of the University’s diverse community of scholars is SLU’s service-focused mission, which challenges and prepares students to make the world a better, more just place.

    Saint Louis University

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  • First-of-its-Kind Study Examines the Impact of Cannabis Use on Surgical Patients’ Post-Procedure Healthcare Needs

    First-of-its-Kind Study Examines the Impact of Cannabis Use on Surgical Patients’ Post-Procedure Healthcare Needs

    BYLINE: Jacqueline Mitchell

    Newswise — BOSTON – As legislation in multiple states eases former restrictions around medical and recreational cannabis in the United States, an increasing proportion of the population reports use of the drug. Between 2016 and 2018, more than 22 percent of Massachusetts residents reported any prior cannabis use for medical or recreational reasons. However, little is known about cannabis use in patients who undergo surgery or interventional procedures, where cannabis use has important additional clinical implications.

    In a new study published in The Lancet’s eClinical Medicine, researchers led by anesthesiologists at Beth Israel Deaconess Medical Center (BIDMC) analyzed de-identified data from patients who underwent non-cardiac surgery in Boston between 2008 and 2020. The scientists found that cannabis users had a higher complexity of co-existing conditions overall, including mood disorders such as depression and substance use disorders. Patients with a diagnosed cannabis use disorder more often required advanced postprocedural healthcare – such as admission to an intensive care unit – compared to non-users. However, patients whose use of cannabis was not classified as a disorder had lower odds of requiring advanced healthcare after surgery compared to patients who never use cannabis.

    “Our analysis revealed that cannabis use is very common and has substantially increased among patients undergoing surgery, reflecting trends in the general population; however, differential effects on postprocedural health care utilization were observed between patients with moderate non-medical cannabis use and patients with a cannabis use disorder,” said corresponding author Maximillian S. Schaefer, Director of the Center for Anesthesia Research Excellence at BIDMC. “We hope our data helps make clinicians aware of how different patterns of cannabis use might represent different patient populations, which in turn translates into distinct perioperative risk profiles.”

    In this hospital registry study, Schaefer and colleagues analyzed de-identified data from 210,639 adult patients undergoing noncardiac surgery at BIDMC between January 2008 and June 2020. Non-medical cannabis use was identified before procedures during routine, structured interviews about past and ongoing habits of drug use, in accordance with the American Society of PeriAnesthesia Nursing recommendations. Patients with cannabis use disorder were identified through diagnostic codes.

    Over the entire study period, the researchers found that more than 16,000 patients, or 7.7 percent, used cannabis prior to surgery, of which 14,045 (87 percent) were identified as non-medical users and 2,166 (13 percent) had a diagnosis of cannabis use disorder. Of all the patients undergoing surgery, a total of 24,516 patients, or 12 percent, required advanced post-procedural healthcare utilization, among which 1,465 patients self-identified as non-medical cannabis users, 418 patients presented with cannabis use disorder and 22,633 patients had no reported ongoing cannabis use.

    Overall, patients who self-identified as cannabis users were on average younger, more often male, and more likely to suffer from depression, anxiety and schizoaffective disorders. Substance use disorders related to alcohol, cocaine, IV drugs, prescription medications and psychedelic drugs were more frequent in patients who used cannabis.

    “As these comorbidities have been associated with increased complications including arrhythmias and sudden cardiac death after anesthesia, a history of cannabis use disorder might serve as an indicator of potentially complicating factor for patients undergoing anesthesia that in turn contribute to the requirement of higher-level healthcare utilization after surgery,” Schaefer said.

    Compared to patients who did not use cannabis, patients with a diagnosis of cannabis use disorder had higher odds of requiring advanced post procedural healthcare utilization. Specifically, a diagnosis of cannabis use disorder was linked with higher odds of a 30-day hospital readmission, compared to patients who did not use cannabis.

    By contrast, patients with reported ongoing non-medical cannabis use had lower odds of advanced post-procedural healthcare unit utilization compared to patients who did not use cannabis. Moreover, such use was linked to shorter hospital length of stay than patients who did not use cannabis. Over the course of the study period, the scientists saw the prevalence of cannabis use rise from 5 percent in 2008 to 14 percent by 2020 and observed higher rates of cannabis use among those undergoing surgery than previous studies reported. While the scientists acknowledge the discrepancy could be the result of regional consumption patterns, they suggest their inclusion of ongoing self-reported non-medical cannabis users based on structured pre-admission interviews paints a more accurate picture than findings that identified patients’ cannabis use on diagnostic codes alone.

    “This cohort represents a distinctively different patient population of more general non-medical users,” said Schaefer. “These differential findings in patients who self-identified as ongoing, non-medical cannabis users without a diagnosis of disorder strongly suggest that future studies need to differentiate these two patient populations. Findings based on the identification of cannabis use from diagnostic codes alone might not be applicable to most mainstream cannabis users.”

    Co-authors included first author Elena Ahrens, Luca J. Wachtendorf, Laetitia S. Chiarella, Sarah Ashrafian, Aiman Suleiman, Tim M. Tartler, Basit A. Azizi, Guangqing Chen, Amnon A. Berge, Denys Shay, Valerie Banner-Goodspeed, Haobo Ma, and Kevin P. Hill, of BIDMC; Bijan Teja, of University of Toronto; and Matthias Eikermann of Albert Einstein College of Medicine.

    This work was supported by an unrestricted, philanthropic grant of Jeff and Judy Buzen. Hill has served as a consultant for Greenwich Biosciences and has received an honorarium from Walters-Klewer as an author. Schaefer received funding for investigator-initiated studies from Merck and Co which do not pertain to this manuscript. Schaefer received honoraria for presentations from Fisher and Paykel healthcare and Mindray medical information international limited period. All other authors declare no competing interests.

     

    Beth Israel Deaconess Medical Center

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  • Using games to promote women’s health and wellbeing in India

    Using games to promote women’s health and wellbeing in India

    Newswise — A new paper in Oxford Open Digital Health, published by Oxford University Press, indicates that it may be possible to use mobile game apps to induce young women to make active decision choices to improve their health and welfare.

    A team of programmers and researchers based in India and the United States worked to create a direct-to-consumer digital platform for mobile games, called Game of Choice, Not Chance, with their first game for adolescent girls called Go Nisha Go. The game uses discovery and play to try to empower young girls to become active decision makers. The game involves a travel adventure story and presents players with challenges, conflicts, and negotiations analogous to what they might encounter in their own lives. Drawing on principles of game-based learning, a player experiences the outcome of her in-game decisions through her avatar, the game’s protagonist. Players also receive feedback on their decisions with the option to play again and experience a different outcome. Throughout the game players also received access to real-world resources that could provide relevant information, skill-building opportunities, and links to healthcare products to help them navigate issues such as menstrual hygiene management and building career skills.

    The objective of this study was to develop psychographic profiles to help game developers create relatable characters. Researchers conducted the study in four Indian cities using a qualitative survey of 105 women ages 15 to 19. They used the survey to collect information on the role models, families, education, dreams, fears, and decision-making powers of the young women.

    Primarily, the researchers note, participants wished to be seen as obedient, respectful toward parents, and a follower of prevalent social norms. Participants also expressed a desire to remain in school as long as possible and enjoy full careers as adults. While the desire to remain in education and pursue a career was widespread, the young women often lacked the necessary means to execute these goals. The participants seemed to have unclear priorities, limited guidance, and an obscure understanding of the impact of small or big choices on their future. The researchers note that developing skills involving being clear about goals, improving negotiation strategies, and understanding the connections between choices and outcomes will be used to improve the game.

    The study’s authors identified four personas of adolescent girls. They will use the traits of these personas to align the game with the intended audience so that the narrative of the game and the scenarios players explore will be relatable and engaging.

    “This study represents a novel approach to research for an equally innovative game for agency-building and health awareness among adolescents,” said the paper’s lead author, Aparna Raj.

    The paper, “Psychographic profiling – a method for developing relatable avatars for a direct-to-consumer mobile game for adolescent girls on mobile in India,” is available at: https://academic.oup.com/oodh/advance-article/doi/10.1093/oodh/oqad001/6979783.

    Oxford University Press

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  • Actinidia arguta (sarunashi) juice inhibits lung cancer in mice

    Actinidia arguta (sarunashi) juice inhibits lung cancer in mice

    Newswise — Lung cancer is the leading cause of death in Japan and across the globe. Among all the cancers, lung cancer has one of the lowest five-year survival rates. Smoking tobacco and using tobacco-based products is known to heavily contribute to the development of lung cancer. It is a clinically established fact that the active ingredients in various fruits minimize the risk of chronic diseases including cancer. “Sarunashi” (Actinidia arguta) is an edible fruit cultivated in Japan’s Okayama Prefecture. Using a mouse model, researchers from Okayama University led by Dr. Sakae Arimoto‑Kobayashi, Associate Professor in the Faculty of Pharmaceutical Sciences, Okayama University, have shown that Sarunashi juice and its constituting component isoquercetin (isoQ) help prevent and reduce lung cancer.

    A. arguta is one of the richest sources of polyphenols and vitamin C. Previously, the researchers had demonstrated the inhibitory effect of Sarunashi juice (sar-j) on mutagenesis, inflammation, and mouse skin tumorigenesis. They had identified the components of A. arguta responsible for the anti-mutagenic effects as water-soluble and heat-sensitive phenolic compounds. Subsequently, the researchers proposed the polyphenolic compound isoQ as a constituting component with anticarcinogenic potential.

    Dr. Arimoto‑Kobayashi explains, “In this study, we sought to investigate the chemopreventive effects of A. arguta juice and its constituting component isoQ on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice, and identify the possible mechanisms underlying the anti-tumorigenic effects of A. arguta.”

    To this end, the team induced tumor growth in mice using NNK, a known cancer-causing compound present in tobacco products. Using a series of experiments and controls, the team studied the effects of sar-j and isoQ on lung tumorigenesis in mice.

    The results were encouraging: The number of tumor nodules per mouse lung in the group that received NNK injections and oral doses of A. arguta juice was significantly lower than that in the group injected with NNK only. Moreover, the oral administration of isoQ also reduced the number of nodules in the mouse lungs.

    Next, the team broke ground by discovering the likely mechanism of action. NNK and 1-methyl-3-nitro-1-nitrosoguanidine or “MNNG” are known mutagens—agents that trigger DNA mutations. The team therefore designed a series of experiments to study the effect of sar-j and isoQ on NNK- and MNNG-mediated mutagenesis using Salmonella typhimurium TA1535—a bacterial strain commonly used for detecting DNA mutations. As expected, the mutagenicity of NNK and MNNG detected using S. typhimurium TA1535 decreased in the presence of sar-j. However, when similar tests were conducted using S. typhimurium YG7108, a strain lacking key enzymes responsible for DNA repair, sar-j was unable to decrease the mutagenic effects of NNK and MNNG. Based on this critical observation, the researchers concluded that sar-j seems to mediate its antimutagenic effect by accelerating DNA repair.

    Finally, using cell-based experiments, the team also showed that sar-j suppressed the action of “Akt,” a key protein involved in cancer signaling. It is a known fact that Akt and an associated protein called “PI3k,” get over-activated in several human cancers.

    Co-author Katsuyuki Kiura, a Professor in the Department of Allergy and Respiratory Medicine, Okayama University Hospital, muses, “Sar-j and isoQ reduced NNK-induced lung tumorigenesis. Sar-j targets both the initiation and growth or progression steps during carcinogenesis, specifically via anti-mutagenesis, stimulation of alkyl DNA adduct repair, and suppression of Akt-mediated growth signaling. IsoQ might contribute in part to the biological effects of sar-j via suppression of Akt phosphorylation, but it may not be the main active ingredient.”

    Their findings were published on 9 December 2022 in Genes and Environment.

    In summary, the study shows that lung tumorigenesis in mice was suppressed following the oral intake of sar-j. Although clinical trials are warranted, the constituting components of sar-j, including isoQ, seem to be attractive candidates for chemoprevention.

     

    About Okayama University, Japan

    As one of the leading universities in Japan, Okayama University aims to create and establish a new paradigm for the sustainable development of the world. Okayama University offers a wide range of academic fields, which become the basis of the integrated graduate schools. This not only allows us to conduct the most advanced and up-to-date research, but also provides an enriching educational experience.

    Website: https://www.okayama-u.ac.jp/index_e.html

    About Dr. Sakae ArimotoKobayashi from Okayama University, Japan

    Dr. Sakae Arimoto‑Kobayashi works as an Associate Professor at Okayama University’s Faculty of Pharmaceutical Sciences. Dr. Arimoto‑Kobayashi has multiple publications to her credit. Her research group primarily conducts studies on mutations and DNA damage induced by N-nitrosamino acids and near-ultraviolet irradiation, analysis of oxidative and alkylative DNA damage caused by the genotoxic agents, anti-carcinogenesis/anti-mutagenesis, and the chemopreventive effect of active ingredients in fruits and drinks.

    Okayama University

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  • Democracy has its flaws, but it has emerged from the pandemic in much ruder health than the alternative | CNN

    Democracy has its flaws, but it has emerged from the pandemic in much ruder health than the alternative | CNN



    CNN
     — 

    For nearly half a decade, you could be forgiven for thinking just about everything in Western democracy seemed a bit broken. The social-media yelling in 140 characters. The wild populism, and dog-whistle racism. The clumsy coronavirus lockdowns and their attendant conspiracy theories. The tolerance of absolute, constant falsehoods. The questioning and beleaguering of the electoral process.

    Some began to behave as if it were smoother on the other side of the fence, in autocracies where things are just ordered to happen, and criticism is swallowed whole.

    Yet, as we stagger past the third anniversary of Covid-19’s emergence, the fallacy that autocracies are a superior social contract is crumbling. At the end of 2022, the world is a place where consent matters, and debate might actually save your hide.

    The Trump era created a safe space for autocracies to flex on the global stage, while American tried to put itself First, and its commander-in-chief was happy to receive “lovely” letters from North Korea, or get very close to the Kremlin. But it took the pandemic to expose the utter mess one man in charge can create.

    The most glaring and unimaginably stark example is Russia. President Vladimir Putin bumbled his way through the pandemic with snap lockdowns, a poorly performing vaccine, and a general disregard for how useful accurate data can be in defeating a complex foe like Nature. But it was his personal choices that led to a disconnect which has proved fatal to tens of thousands of innocent Ukrainians, and perhaps even more Russian soldiers.

    The persistent warnings from Western intelligence in January that an invasion of Ukraine was imminent seemed far-fetched to many analysts, including me. Those analysts overlooked the enormity of the task, and the assumption the Kremlin remained a rational actor. Those calming caveats were swiftly whisked away when – in the days leading up to the war – Putin summoned his security henchmen and dressed them down, at a safe distance of well over 20 feet, and then delivered a 57-minute televised speech showing he had spent the pandemic reading all the wrong parts of the internet.

    His spoken dissertation even reminded Russians how mean Bill Clinton had been 20 years ago, shunning Putin’s stated desire to join NATO. Putin’s isolation had compounded not just his historical grievances. There were now fewer subordinates in contact with him, and fewer opinions voiced to counter the absurd assumption Russia’s invasion would be welcomed by Ukrainians and last about three days.

    A RUSI report recently noted that seized Russian orders showed units expected to be “cleaning up” within 10 days, and that no effective “red team” assessment of the plan – challenging its assumptions – had happened.

    And so, the largest land war in Europe for 75 years began, and with it a likely military defeat for Russia that may rewrite the established norms of European security and see Moscow’s place as a global superpower evaporate. Putin’s insecurities over NATO and the practical task of connecting the occupied Crimean Peninsula to the Russian mainland fueled his catastrophic decision. But the Kremlin head’s isolation – along with his echo chamber of paranoid nonsense – cemented it.

    But even now, in this late stage in the Russian military demise, when its readiest form of resupply is forced conscripts to the frontline, Moscow must be mindful of consent. The “partial mobilization” announced in September has sent 77,000 Russian men to Ukraine, Putin recently said. But it has also unleashed a wave of protests perhaps not seen in Russia since the 1990s.

    Tightening the screws on dissent is a sign opposition is growing, not ebbing. The nastier Russia gets, the more acutely aware the Kremlin is of its unpopularity. Invading Ukraine was the worst decision a Russian leader has made since the Soviets invaded Afghanistan. We know how that misadventure ended.

    Police officers detain demonstrators in St. Petersburg on September 21, 2022, following calls to protest against partial military mobilisation announced by President Vladimir Putin.

    The pandemic caused economic and emotional stress in every society, leaving citizens less tolerant of poor managers and outdated dogma. Even the United Kingdom swiftly ejected two prime ministers over issues of conduct and incompetence, not long after their ruling Conservative Party had won a landslide victory at the last election.

    The economic fallout from the pandemic is also the backdrop for another dazzling failure of autocracy, in Iran. But the focal point of recent protests has been the brutal treatment of teenagers for protesting mandatory headscarves. Killing a young woman for not wanting to dress more conservatively than her grandmother perhaps did (Iran was – as recently as the 1970s – secular) is grotesque in any society.

    Iranians protest the death of 22-year-old Mahsa Amini after she was detained by the morality police, in Tehran, Iran, on October 1, 2022.

    But it lit the touch paper in communities ravaged by years of sanctions, the pandemic, and persistent inflation of perhaps as much as 50%. Permit salaries and savings to diminish that much annually, and any elected government could expect to be ousted fast. In Iran’s cities, the violence around this dogma did not distract from the economic fury, but amplify it.

    Well over half of Iran’s population was born in the 1990s, when the Islamic Revolution was already a decade old. A system born in the era of the landline is telling youth born into the world of fax machines how to behave in the era of quantum computing.

    The pandemic hit Iran hard, and I witnessed in 2020 how poorly resourced Tehran’s hospitals were. When your parent is dying and you can’t get a ventilator for them, you don’t have time for a lengthy discourse blaming US sanctions imposed because of Iran’s confrontation of the American hegemony in the region. An emergency like Covid can damage what remains of the contract between ruling conservatives and citizens: If you cannot protect us from a disease at our time of need, then what is the purpose of the corruption, repression and rules on women’s dress?

    Medical workers transport a patient with Covid-19 at Rasoul Akram Hospital in Tehran on October 20, 2020.

    The recent public confusion over whether the country’s morality police would be disbanded – a statement made by the prosecutor general which was later mauled – is a sign of government reform perhaps, but also an indication of how state power is not a tidy behemoth in Iran. There is debate, too, and here it clearly, with hundreds of corpses already underfoot, considered bending to popular will.

    This stark and deadly repression does not at this time herald the demise of the Iranian regime. But it is perhaps a moment of irreversible acceptance that the people cannot just be Ctrl-Alt-Deleted when they don’t suit the state program. It is a recognition that even the best-resourced, most controlling and efficient of repressive regimes – China – has had to deal with.

    Iranians protest the death of 22-year-old Mahsa Amini after she was detained by the morality police, in Tehran on October 27, 2022.

    The pandemic led Beijing to resort to mass control on a whole new level. Its solution to the disease ravaging the planet was to be the harshest of all – in limiting movement. The authorities’ favored tool – used to its limits – was the one almost every other society realized would not work indefinitely.

    Until recently, Chinese citizens were still being welded into their homes in quarantine, and even burning to death in one tragic instance when they perhaps could have been rescued from a domestic fire. It’s perhaps the most damning indictment of China’s one-person rule this century.

    Workers in  protective clothes walk past barriers placed to close off streets in areas locked down after the detection of cases of Covid-19 in Shanghai on March 15, 2022.

    The world has been on a steep learning curve, where social distancing, economic subsidies, vaccines, agonizing deaths and limited global travel have led most societies to now accept the Covid-esque persistent cough as part of what happens in winter. Yet China’s initial decision – stifle the disease – has barely evolved. Its vaccine program has faltered, yet its original tool of mass surveillance has not.

    What is more remarkable is not protests breaking out under such an authoritarian yoke, but that President Xi Jinping did not presume they would.

    Beijing appeared to have been taken by surprise, but also believed it could repress its way out of the unrest. The recent removal of significant parts of the quarantine and testing systems does not solve China’s Covid problems. It was simply their authorities’ only choice. And it is a badly timed one. China is not adequately vaccinated to cope with a massive rise in cases, particularly its elderly population, many experts argue. Even if 1% catch it badly, that is 14 million people in need of medical care – roughly the population of Zimbabwe.

    A demonstrator holds a blank sign and chants slogans during a protest in Beijing, China, on Monday, November 28, 2022.

    Huge challenges require decision-makers of enormous ability. Xi has unparalleled power, evidenced when he sat by as his predecessor Hu Jintao was inexplicably led out during the highly choreographed closing moments of the recent National Congress. But it is pretty clear that Xi got the big decisions around Covid wrong. And that the country where SARS-Cov-2 first emerged is enduring the longest impact of the virus because of poor decisions by its leaders.

    It is a problem for Xi. The singular selling point of autocratic power is that it is absolute: that you can get things done without the delay of debate and compromise that democratic systems endure.

    The point is to be strong, implement decisions fast, and consider dissent the cost of tough, good decisions; not to appear strong, implement fast, and then change your mind publicly after months pursuing a bad idea. For Xi, it is also dangerous for a population to learn they can only truly communicate with their government through disobedience and protest.

    It’s important to feel discomfort when extolling the virtues of modern democracy. It doesn’t really work. It is slow and encourages ego and half-measures. It keeps changing its mind and wasting endless resources while stumbling for the solution.

    But it provides space for dissent and, more importantly, other, competing ideas. And, if you are forcing taxi drivers to fight in a war of choice you are losing, or shooting teenagers for taking off headscarves, or imprisoning people in their apartments to suppress a virus the rest of the world is living calmly with, alternative ideas are important.

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