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Tag: Aging

  • Researchers uncover factors linked to optimal aging

    Researchers uncover factors linked to optimal aging

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    Newswise — What are the keys to “successful” or optimal aging? A new study followed more than 7000 middle aged and older Canadians for approximately three years to identify the factors linked to well-being as we age.

    They found that those who were female, married, physically active and not obese and those who had never smoked, had higher incomes, and who did not have insomnia, heart disease or arthritis, were more likely to maintain excellent health across the study period and less likely to develop disabling cognitive, physical, or emotional problems.

    As a baseline, the researchers selected participants who were in excellent health at the start of the approximately three-year period of study. This included the absence of memory problems or chronic disabling pain, freedom from any serious mental illness and absence of physical disabilities that limit daily activities — as well as the presence of adequate social support and high levels of happiness and life satisfaction.

    “We were surprised and delighted to learn that more than 70% of our sample maintained their excellent state of health across the study period,” says the first author, Mabel Ho, a doctoral candidate at the University of Toronto’s Factor-Inwentash Faculty of Social Work (FIFSW) and the Institute of Life Course and Aging. “Our findings underline the importance of a strength-based rather than a deficit-based focus on aging and older adults. The media and research tend to ignore the positive and just focus on the problems.”

    There was considerable variation in the prevalence of successful aging based on the respondents’ age at the beginning of the study. Three quarters of the respondents who were aged 55 to 64 at the start of the study period maintained excellent health throughout the study. Among those aged 80 and older, approximately half remained in excellent health.

    “It is remarkable that half of those aged 80 and older maintained this extremely high bar of cognitive, physical, and emotional well-being across the three years of the study. This is wonderful news for older adults and their families who may anticipate that precipitous decline is inevitable for those aged 80 and older.”  says Mabel Ho. “By understanding factors associated with successful aging, we can work with older adults, families, practitioners, policymakers, and researchers to create an environment that supports a vibrant and healthy later life.”

    Older adults who were obese were less likely to maintain good health in later life. Compared to older adults who were obese, those who had a normal weight were 24% more likely to age optimally.

    “Our findings are in keeping with other studies which have found that obesity was related to a range of physical symptoms and cognitive problems and that physical activity also plays a key role in optimal aging,” says co-author David Burnes, Associate Professor at the University of Toronto’s FIFSW and a Canada Research Chair in Older Adult Mistreatment Prevention. “These findings highlight the importance of maintaining an appropriate weight and engaging in an active lifestyle throughout the life course”.

    Income was also as an important factor. Only about half of those below the poverty line aged optimally compared to three-quarters of those living above the poverty line.

    “Although our study does not provide information on why low income is important, it is possible that inadequate income causes stress and also restricts healthy choices such as optimal nutrition. Future research is needed to further explore this relationship,” says senior author Esme Fuller-Thomson, Director of the Institute for Life Course & Aging and Professor at the University of Toronto’s Factor-Inwentash Faculty of Social Work.

    Lifestyle factors are associated with optimal health in later life. Older adults who never smoked were 46% more likely to maintain an excellent state of health compared to current smokers. Previous studies showed that quitting smoking in later life could improve survival statistics, pulmonary function, and quality of life; lower rates of coronary events, and reduce respiratory symptoms. The study found that former smokers did as well as those who had never smoked, underscoring that it is never too late to quit.

    The study also found that engaging in physical activity was important in maintaining good health in later life. Older adults who engaged in moderate to strenuous physical activity were 35% to 45% more likely to age well, respectively.

    The findings indicated that respondents who never or rarely experienced sleep problems at baseline were 29% more likely to maintain excellent health across the study.

    “Clearly, good sleep is an important factor as we age. Sleep problems undermine cognitive, mental, and physical health. There is strong evidence that an intervention called cognitive-behavioral therapy for insomnia (CBT-I) is very helpful for people living with insomnia,” says Esme Fuller-Thomson.

    The study was recently published online, in the International Journal of Environmental Research and Public Health. It uses longitudinal data from the baseline wave (2011-2015) and the first follow-up wave (2015-2018) of data from the Canadian Longitudinal Study on Aging (CLSA) to examine factors associated with optimal aging the first two waves. In the CLSA, there were 7,651 respondents who were aged 60 years or older at wave 2 who were in optimal health during the baseline wave of data collection. The sample was restricted to those who were in excellent health at baseline, which was only 45% of the respondents.

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    University of Toronto

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  • Are You an Optimist? Could You Learn to Be? Your Health May Depend on It.

    Are You an Optimist? Could You Learn to Be? Your Health May Depend on It.

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    By Judith Graham

    Tuesday, December 13, 2022 (Kaiser News) — When you think about the future, do you expect good or bad things to happen?

    If you weigh in on the “good” side, you’re an optimist. And that has positive implications for your health in later life.

    Multiple studies show a strong association between higher levels of optimism and a reduced risk of conditions such as heart disease, stroke, and cognitive impairment. Several studies have also linked optimism with greater longevity.

    One of the latest, published this year, comes from researchers at Harvard’s T.H. Chan School of Public Health in collaboration with colleagues at other universities. It found that older women who scored highest on measures of optimism lived 4.4 years longer, on average, than those with the lowest scores. Results held true across races and ethnicities.

    Why would optimism make such a difference?

    Experts advance various explanations: People who are optimistic cope better with the challenges of daily life and are less likely to experience stress than people with less positive attitudes. They’re more likely to eat well and exercise, and they often have stronger networks of family and friends who can provide assistance.

    Also, people who are optimistic tend to engage more effectively in problem-solving strategies and to be better at regulating their emotions.

    Of course, a feedback loop is at play here: People may be more likely to experience optimism if they enjoy good health and a good quality of life. But optimism isn’t confined to those who are doing well. Studies suggest that it is a genetically heritable trait and that it can be cultivated through concerted interventions.

    What does optimism look like in practice? For answers, I talked to several older adults who identify as optimists but who don’t take this characteristic for granted. Instead, it’s a choice they make every day.

    Patricia Reeves, 73, Oklahoma City. “I’ve had a fairly good life, but I’ve had my share of traumas, like everyone,” said Reeves, a widow of seven years who lives alone. “I think it’s my faith and my optimism that’s pulled me through.”

    A longtime teacher and school principal, Reeves retired to care for her parents and her second husband, a Baptist minister, before they died. During the covid-19 pandemic, she said, “I’ve been developing my spirituality.”

    When I asked what optimism meant to her, Reeves said: “You can see the good in each situation, or you can see the negative. When something isn’t going the way I wish, I prefer to ask myself, ‘What am I learning from this? What part did I play in this, and am I repeating patterns of behavior? How can I change?’”

    As for the challenges that come with aging — the loss of friends and family, health issues — Reeves spoke of optimism as a “can-do” attitude that keeps her going. “You don’t spend your time concentrating on your health or thinking about your aches and pains. You take them in as a fact, and then you let them go,” she said. “Or if you’ve got a problem you can solve, you figure out how to solve it, and you move on to tomorrow.”

    “There’s always something to be grateful for, and you focus on that.”

    Grace Harvey, 100, LaGrange, Georgia. “I look for the best to happen under any circumstances,” said Harvey, a retired teacher and a devoted Baptist. “You can work through any situation with the help of God.”

    Her parents, a farmer and a teacher in Georgia, barely earned enough to get by. “Even though you would classify us as poor, I didn’t think of myself as poor,” she said. “I just thought of myself as blessed to have parents doing the best they could.”

    Today, Harvey lives in a mobile home and teaches Sunday school. She never married or had children, but she was surrounded by loving family members and former students at her 100th birthday party in October.

    “Not having my own family, I was able to touch the lives of many others,” she said. “I feel grateful for God letting me live this long: I still want to be around to help somebody.”

    Ron Fegley, 82, Placer County, California. “I’m positive about the future because I think in the long run things keep getting better,” said Fegley, a retired physicist who lives in the Sierra Nevada foothills with his wife.

    “Science is a very important part of my life, and science is always on the upwards path,” he continued. “People may have the wrong ideas for a while, but eventually new experiments and data come along and correct things.”

    Fegley tends a small orchard where he grows peaches, cherries, and pears. “We don’t know what’s going to happen; no one does,” he told me. “But we enjoy our life currently, and we’re just going to go on enjoying it as much as we can.”

    Anita Lerek, over 65, Toronto. “I was a very troubled younger person,” said Lerek, who declined to give her exact age. “Some of that had to do with the fact my parents were Holocaust survivors and joy was not a major part of their menu. They struggled a lot, and I was full of resentment.”

    When I asked her about optimism, Lerek described exploring Buddhism and learning to take responsibility for her thoughts and actions. “Mine is a cultivated optimism,” she told me. “I go to my books — Buddhist teachings, the Talmud — they’ve taught me a lot. You face all your demons, and you cultivate a garden of wisdom and projects and emotional connections.”

    At this point in life, “I’m grateful for every moment, every experience, because I know it could end any moment,” said Lerek, a lawyer and entrepreneur who writes poetry and still works part time. “It boils down to, ‘Is the glass half-empty or half-full?’ I choose the fullness.”

    Katharine Esty, 88, Concord, Massachusetts. When Esty fell into a funk after turning 80, she looked for a guide to what to expect in the decade ahead. One didn’t exist, so she wrote “Eightysomethings: A Practical Guide to Letting Go, Aging Well, and Finding Unexpected Happiness.”

    For the project, Esty, a social psychologist and psychotherapist, interviewed 128 people in their 80s. “The more people I talked with, the happier I became,” she told me. “People were doing interesting things, leading interesting lives, even though they were coping with a lot of losses.

    “Not only was I learning stuff, having this purpose and focus brought me a tremendous amount of joy. My vision of what was possible in old age was greatly expanded.”

    Part of what Esty learned is the importance of “letting go of our inner vision of what our life should be and being open to what’s really happening.”

    For example, after stomach surgery last year, Esty needed physical therapy and had to use a walker. “I had always prided myself on being a very active person, and I had to accept my vulnerability,” she said. Similarly, although her 87-year-old boyfriend thought he’d spend his retirement fishing in Maine, he can’t walk well now, and that’s not possible.

    “I have come to think that you choose your attitude, and optimism is an attitude,” said Esty, who lives in a retirement community. “Now that I’m 88, my task is to live in the present and believe that things will be better, maybe not in my lifetime but decades from now. Life will prevail, the world will go on — it’s a sort of trust, I think.

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  • Aging is driven by unbalanced genes

    Aging is driven by unbalanced genes

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    • New study finds that most molecular-level changes that occur during aging are associated with gene length
    • Organisms balance the activity of short and long genes
    • Aging is accompanied by a shift in gene activity toward short genes, which are associated with accelerated aging
    • Researcher: ‘Aging is a subtle imbalance, away from equilibrium’ that requires your cells to expend more effort to function properly
    • Findings could lead to medical interventions that slow or even reverse the biological hallmarks of aging

    Newswise — EVANSTON, Ill. — Northwestern University researchers have discovered a previously unknown mechanism that drives aging.

    In a new study, researchers used artificial intelligence to analyze data from a wide variety of tissues, collected from humans, mice, rats and killifish. They discovered that the length of genes can explain most molecular-level changes that occur during aging.

    All cells must balance the activity of long and short genes. The researchers found that longer genes are linked to longer lifespans, and shorter genes are linked to shorter lifespans. They also found that aging genes change their activity according to length. More specifically, aging is accompanied by a shift in activity toward short genes. This causes the gene activity in cells to become unbalanced.

    Surprisingly, this finding was near universal. The researchers uncovered this pattern across several animals, including humans, and across many tissues (blood, muscle, bone and organs, including liver, heart, intestines, brain and lungs) analyzed in the study.

    The new finding potentially could lead to interventions designed to slow the pace of — or even reverse — aging.

    The study will be published on Dec. 9 in the journal Nature Aging.

    “The changes in the activity of genes are very, very small, and these small changes involve thousands of genes,” said Northwestern’s Thomas Stoeger, who led the study. “We found this change was consistent across different tissues and in different animals. We found it almost everywhere. I find it very elegant that a single, relatively concise principle seems to account for nearly all of the changes in activity of genes that happen in animals as they age.”

    “The imbalance of genes causes aging because cells and organisms work to remain balanced — what physicians denote as homeostasis,” said Northwestern’s Luís A.N. Amaral, a senior author of the study. “Imagine a waiter carrying a big tray. That tray needs to have everything balanced. If the tray is not balanced, then the waiter needs to put in extra effort to fight the imbalance. If the balance in the activity of short and long genes shifts in an organism, the same thing happens. It’s like aging is this subtle imbalance, away from equilibrium. Small changes in genes do not seem like a big deal, but these subtle changes are bearing down on you, requiring more effort.”

    An expert in complex systems, Amaral is the Erastus Otis Haven Professor of Chemical and Biological Engineering in Northwestern’s McCormick School of Engineering. Stoeger is a postdoctoral scholar in Amaral’s laboratory.

    Looking across ages

    To conduct the study, the researchers used various large datasets, including the Genotype-Tissue Expression Project, a National Institutes of Health-funded tissue bank that archives samples from human donors for research purposes.

    The research team first analyzed tissue samples from mice — aged 4 months, 9 months, 12 months, 18 months and 24 months. They noticed the median length of genes shifted between the ages of 4 months and 9 months, a finding that hinted at a process with an early onset. Then, the team analyzed samples from rats, aged 6 months to 24 months, and killifish, aged 5 weeks to 39 weeks.

    “There already seems to be something happening early in life, but it becomes more pronounced with age,” Stoeger said. “It seems that, at a young age, our cells are able to counter perturbations that would lead to an imbalance in gene activity. Then, suddenly, our cells are no longer able to counter it.”

    After completing this research, the researchers turned their attention to humans. They looked at changes in human genes from ages 30 to 49, 50 to 69 and then 70 and older. Measurable changes in gene activity according to gene length already occurred by the time humans reached middle age.

    “The result for humans is very strong because we have more samples for humans than for other animals,” Amaral said. “It was also interesting because all the mice we studied are genetically identical, the same gender and raised in the same laboratory conditions, but the humans are all different. They all died from different causes and at different ages. We analyzed samples from men and women separately and found the same pattern.”

    ‘Systems-level’ changes

    In all animals, the researchers noticed subtle changes to thousands of different genes across samples. This means that not just a small subset of genes that contributes to aging. Aging, instead, is characterized by systems-level changes.

    This view differs from prevailing biological approaches that study the effects of single genes. Since the onset of modern genetics in the early 20th century, many researchers expected to be able to attribute many complex biological phenomena to single genes. And while some diseases, such as hemophilia, do result from single gene mutations, the narrow approach to studying single genes has yet to lead to explanations for the myriad changes that occur in neurodegenerative diseases and aging.

    “We have been primarily focusing on a small number of genes, thinking that a few genes would explain disease,” Amaral said. “So, maybe we were not focused on the right thing before. Now that we have this new understanding, it’s like having a new instrument. It’s like Galileo with a telescope, looking at space. Looking at gene activity through this new lens will enable us to see biological phenomena differently.”

    Lengthy insights

    After compiling the large datasets, many of which were used in other studies by researchers at Northwestern University Feinberg School of Medicine and in studies outside Northwestern, Stoeger brainstormed an idea to examine genes, based on their length.

    The length of a gene is based on the number of nucleotides within it. Each string of nucleotides translates to an amino acid, which then forms a protein. A very long gene, therefore, yields a large protein. And a short gene yields a small protein. According to Stoeger and Amaral, a cell needs to have a balanced number of small and large proteins to achieve homeostasis. Problems occur when that balance gets out of whack. 

    Although the researchers did find that long genes are associated with increased lifespans, short genes also play important roles in the body. For example, short genes are called upon to help fight off pathogens.

    “Some short genes could have a short-term advantage on survival at the expense of ultimate lifespan,” Stoeger said. “Thus, outside of a research laboratory, these short genes might help survival under harsh conditions at the expense of shortening the animal’s ultimate lifespan.”

    Suspected ties to long COVID-19

    This finding also may help explain why bodies take longer to heal from illnesses as they age. Even with a simple injury like a paper cut, an older person’s skin takes a longer time to recover. Because of the imbalance, cells have fewer reserves to counteract the injury. 

    “Instead of just dealing with the cut, the body also has to deal with this activity imbalance,” Amaral hypothesized. “It could explain why, over time with aging, we don’t handle environmental challenges as well as when we were younger.”

    And because thousands of genes change at the system-level, it doesn’t matter where the illness starts. This could potentially explain illnesses like long COVID-19. Although a patient might recover from the initial virus, the body experiences damage elsewhere.

    “We know cases where infections — predominantly viral infections — lead to other problems later in life,” Amaral said. “Some viral infections can lead to cancer. Damage moves away from the infected site and affects other areas of our body, which then is less able to fight environmental challenges.”

    Hope for medical interventions

    The researchers believe their findings could open new venues for the development of therapeutics, designed to reverse or slow aging. Current therapeutics to treat illness, the researchers argue, are merely targeting the symptoms of aging rather than aging itself. Amaral and Stoeger compare it to using Tylenol to reduce a fever instead of treating the illness that caused the fever.

    “Fevers can occur for many, many reasons,” Amaral said. “It could be caused by an infection, which requires antibiotics to cure, or caused by appendicitis, which requires surgery. Here, it’s the same thing. The issue is the gene activity imbalance. If you can help correct the imbalance, then you can address the downstream consequences.”

    Other Northwestern co-senior authors include Richard Morimoto, a professor of molecular biosciences in the Weinberg College of Arts and Sciences; Dr. Alexander Misharin, an associate professor of medicine at Feinberg; and Dr. G.R. Scott Budinger, the Ernest S. Bazley Professor of Airway Diseases at Feinberg and chief of pulmonary and critical care at Northwestern Medicine. 

    The study, “Aging is associated with a systemic length-associated transcriptome imbalance,” was supported by the Office of the Assistant Secretary of Defense for Health Affairs, the U.S. Department of Defense, the National Institutes of Health (grant numbers AG068544, AG049665, AG054407, AG026647, AG057296, AG059579), the Veterans Administration, the National Science Foundation and a gift from John and Leslie McQuown.

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    Northwestern University

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  • Researchers discover rare form of premature-aging syndrome

    Researchers discover rare form of premature-aging syndrome

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    Newswise — DALLAS – Dec. 8, 2022 – UT Southwestern researchers have discovered a new form of progeria, a rare premature-aging syndrome, in a man from Malaysia and traced its cause to a novel gene mutation. The finding, reported in the Journal of Clinical Investigation, could lead to new therapies for more common conditions that share features with this ultra-rare disorder.

    “We realized that this is not like the progeroid syndromes we have seen in the past. It is a completely new subtype,” said study leader Abhimanyu Garg, M.D., Professor of Internal Medicine at UTSW, Section Chief of Nutrition and Metabolic Diseases in the Division of Endocrinology, and Director of Metabolic Diseases in the Center for Human Nutrition. “We wanted to see whether we could find the gene behind it.”

    Dr. Garg explained that colleagues in Malaysia had encountered a patient of Chinese descent with a highly unusual combination of physical characteristics. The 21-year-old male was 3.8 feet tall, weighed 46 pounds, and had a head circumference of 21 inches, all below the lowest 3% of the general population. He also had a unique set of facial features, with a pointed nose, thin lips, a small lower jaw, and severe dental crowding, as well as very low body fat – a condition known as lipodystrophy – and extremely poor vision.

    Because Dr. Garg’s lab focuses on lipodystrophy research and had previously discovered the genetic mutations behind a condition called mandibuloacral dysplasia (MAD), which the Malaysian researchers believed this patient had, they sent Dr. Garg the patient’s blood samples to confirm their tentative diagnosis. However, when Dr. Garg and his colleagues performed genetic testing, they found the patient lacked mutations in either of the two genes linked to MAD.

    Suspecting the patient might have an undiscovered condition, Dr. Garg and his collaborators scanned the entire genomes of the patient and his immediate family members for any unusual gene variants. They quickly narrowed their search to a single gene known as TOMM7.

    From animal studies, this gene was known to produce a protein that comes together in a complex with related proteins to form a pore in the outer membrane of mitochondria, the power-generating organelles of cells.

    To better understand its function in humans, the researchers grew skin cells from a sample derived from the patient and compared them to skin cells from healthy volunteers. Tests showed that the patient’s cells consumed far more oxygen than the healthy cells and produced greater amounts of proteins related to oxygen metabolism. They also produced fewer proteins related to phospholipid metabolism, a process involved in the formation of body fat.

    Further experiments showed that the mutant TOMM7 protein from the patient didn’t interact well with other proteins that form the mitochondrial pore complex. This functional defect, Dr. Garg said, could limit the transportation of proteins through the pore, pointing to a mechanism for the patient’s symptoms.

    Dr. Garg said that more common variants in this gene could help explain population-wide differences in characteristics exaggerated in this patient, such as height, jaw size, body fat, and vision. In addition, because the patient had an older sister who appeared to have the same genetic syndrome and died at age 10, further research on this gene variant could clarify genetic factors that affect aging – and may also eventually lead to a cure for this individual, who may be in danger, Dr. Garg said.

    “We don’t know what his life span may be, but based on what we know about his sister, he may be at risk of premature death,” he said. “I hope other scientists will take it to the next level and figure out a specific treatment that could save this patient from that fate.”

    Dr. Garg holds the Distinguished Chair in Human Nutrition Research.

    Other researchers who contributed to this study include Adwait Amod Sathe, Chao Xing, Anil K. Agarwal, and Prashant Mishra of UTSW; Yanqiu Shao of UTSW and Southern Methodist University; Wee-Teik Keng of Kuala Lumpur Hospital in Malaysia; Zhenkang Chen, Nicholas P. Lesner, and Claire B. Llamas of Children’s Medical Center Research Institute at UT Southwestern; and Pavithira Devi Kailasam of Hospital Pakar Sultanah Fatimah in Malaysia.

    About UT Southwestern Medical Center

    UT Southwestern, one of the nation’s premier academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes, and includes 24 members of the National Academy of Sciences, 18 members of the National Academy of Medicine, and 14 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,900 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in more than 80 specialties to more than 100,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 4 million outpatient visits a year.

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    UT Southwestern Medical Center

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  • Flu shots are recommended for those 65 and older as cases rise

    Flu shots are recommended for those 65 and older as cases rise

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    Newswise — DALLAS – Nov. 30, 2022 – With flu cases on the rise, geriatric specialists at UT Southwestern Medical Center say vaccinations are particularly important this year for people 65 and older who are more at risk from complications than other age groups. 

    As we age, our immune system changes, making us more susceptible to infections like influenza. Older adults make up 70%-85% of seasonal flu-related deaths in the United States and account for 50%-70% of hospitalizations from influenza, according to the Centers for Disease Control and Prevention. Even older adults who spend most of their time at home have family members or home health aides visit, providing opportunities for the influenza virus to spread. The Texas Department of State Health Services has reported a higher number of influenza-like illnesses statewide so far this season compared with recent years.

    “It is important to take action now to prevent the possibility of severe infections, especially for populations at higher risk for complications, which includes older adults,” said geriatrician Deborah Freeland, M.D., Assistant Professor of Internal Medicine at UT Southwestern. “Because the influenza virus changes over time, we need annual vaccinations to help protect against infection and reduce the severity of infection.”

    Dr. Freeland recommends that those age 65 and older get a high-dose influenza vaccine. Research shows that high-dose vaccines reduced the risk of infection by 24% in older adults compared with the standard dose. In addition, the influenza vaccination is shown to lower the risk of heart attacks and death. It can take up to two weeks for the vaccine to become effective, and flu season is already in full swing, so Dr. Freeland advises people to obtain the vaccine as soon as possible.

    Wearing masks in crowded places and washing hands regularly are additional steps people can take to stay healthy. It’s also important for those living with older adults to get the flu vaccine to help decrease the spread of infection to groups at greater risk.

    While some older adults refrain from getting the flu vaccine for fear of catching the flu, Dr. Freeland said vaccines cannot cause influenza infections. However, there can be side effects, including soreness at the injection site, headache, fever, nausea, and muscle aches, which typically resolve within 24-48 hours. UT Southwestern offers flu shots to patients at several locations; they are also available at local pharmacies, doctor’s offices, and other locations.   

    “There is robust data behind the benefits of influenza vaccination,” Dr. Freeland said. “Get your flu vaccination today to protect yourself and those around you.”

    About UT Southwestern Medical Center

    UT Southwestern, one of the nation’s premier academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes, and includes 24 members of the National Academy of Sciences, 18 members of the National Academy of Medicine, and 14 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,900 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in more than 80 specialties to more than 100,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 4 million outpatient visits a year.

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    UT Southwestern Medical Center

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  • Is weakness the new smoking? Muscle strength tied to biological age, study shows

    Is weakness the new smoking? Muscle strength tied to biological age, study shows

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    Newswise — Everyone ages at a different pace. That’s why two 50-year-olds, despite living the same number of years, may have different biological ages – meaning that a host of intrinsic and extrinsic factors have caused them to age at varying paces with different levels of risk for disease and early death.

    Lifestyle choices, such as diet and smoking, and illness all contribute to accelerating biological age beyond one’s chronological age. In other words, your body is aging faster than expected. And for the first time, researchers have found that muscle weakness marked by grip strength, a proxy for overall strength capacity, is associated with accelerated biological age. Specifically, the weaker your grip strength, the older your biological age, according to results published in The Journal of Cachexia, Sarcopenia and Muscle.

    Researchers at Michigan Medicine modeled the relationship between biological age and grip strength of 1,274 middle aged and older adults using three “age acceleration clocks” based on DNA methylation, a process that provides a molecular biomarker and estimator of the pace of aging. The clocks were originally modeled from various studies examining diabetes, cardiovascular disease, cancer, physical disability, Alzheimer’s disease, inflammation and early mortality.

    Results reveal that both older men and women showed an association between lower grip strength and biological age acceleration across the DNA methylation clocks.

    “We’ve known that muscular strength is a predictor of longevity, and that weakness is a powerful indicator of disease and mortality, but, for the first time, we have found strong evidence of a biological link between muscle weakness and actual acceleration in biological age,” said Mark Peterson, Ph.D., M.S., lead author of the study and associate professor of physical medicine and rehabilitation at University of Michigan.

    “This suggests that if you maintain your muscle strength across the lifespan, you may be able to protect against many common age-related diseases. We know that smoking, for example, can be a powerful predictor of disease and mortality, but now we know that muscle weakness could be the new smoking.”

    The real strength of this study was in the eight to 10 years of observation, in which lower grip strength predicted faster biological aging measured up to a decade later, said Jessica Faul, Ph.D., M.P.H., a co-author of the study and research associate professor at the U-M Institute for Social Research.

    Past studies have shown that low grip strength is an extremely strong predictor of adverse health events. One study even found that it is a better predictor of cardiovascular events, such as myocardial infarction, than systolic blood pressure – the clinical hallmark for detecting heart disorders. Peterson and his team have previously shown a robust association between weakness and chronic disease and mortality across populations.

    This evidence coupled with their study’s recent findings, Peterson says, shows potential for clinicians to adopt the use of grip strength as a way to screen individuals for future risk of functional decline, chronic disease and even early mortality.

    “Screening for grip strength would allow for the opportunity to design interventions to delay or prevent the onset or progression of these adverse ‘age-related’ health events,” he said. “We have been pushing for clinicians to start using grip strength in their clinics and only in geriatrics has this sort of been incorporated. However, not many people are using this, even though we’ve seen hundreds of publications showing that grip strength is a really good measure of health.”

    Investigators say future research is needed to understand the connection between grip strength and age acceleration, including how inflammatory conditions contribute to age-related weakness and mortality. Previous studies have shown that chronic inflammation in aging – known as “inflammaging” – is a significant risk factor for mortality among older adults. This inflammation is also associated with lower grip strength and may be a significant predictor on the pathway between lower grip strength and both disability and chronic disease multimorbidity.

    Additionally, Peterson says, studies must focus on how lifestyle and behavioral factors, such as physical activity and diet, can affect grip strength and age acceleration.

    “Healthy dietary habits are very important, but I think regular exercise is the most critical thing that somebody can do to preserve health across the lifespan,” he said. “We can show it with a biomarker like DNA methylation age, and we can also test it with a clinical feature like grip strength.”

    Additional authors include Stacey Collins, M.A., Helen C.S. Meier, Ph.D., M.P.H., Alexander Brahmsteadt, M.D., all of University of Michigan.

    This work was supported in part by the National Institutes of Health (NIH) grant (R01 AG060110 to J.F.).
    Paper cited: “Grip strength is inversely associated with DNA methylation age acceleration,” The Journal of Cachexia, Sarcopenia and Muscle. DOI: 10.1002/jcsm.13110

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    Michigan Medicine – University of Michigan

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  • Q&A: Health Challenges Facing Aging Latinos

    Q&A: Health Challenges Facing Aging Latinos

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    Alicia Arbaje, MD, PhD, MPH, associate professor at Johns Hopkins School of Medicine, talks to WebMD about the health challenges of elders in America’s many Hispanic communities. 

    This interview was edited for length and clarity. 


    WebMD: What’s the best way to refer to people with Hispanic roots or identities in a medical context? 


    Arbaje: This is a great question. The terms are important and unfortunately many of them were put upon us by other cultures and because of a history of colonization. For example, the “Latinx” term is not well embraced by the Latino population – especially older adults. It’s also not widely used in the scientific literature or in geriatrics, though this may change over time. 

    We see “Latino,” “Latina,” and “Hispanic,” but there’s no great term. This can cause a problem with how data is collected for this population. The best thing to do when working with people of Latin descent is to meet people where they are and ask them to self-identify. Most people tend to identify themselves by nationality (i.e., Puerto Rican, Dominican, etc.). When you put everyone together in one bucket it can sometimes discount the rich diversity and even different health backgrounds.

    [For this Q&A with Dr. Arbaje, WebMD will use the terms Hispanic and Latino to refer to anyone who may have roots in Latin America and parts of the Caribbean.]


    WebMD: What are the biggest health challenges for today’s aging Hispanic population?


    Arbaje: In general, they’re the same issues that happen in most aging populations: Heart disease, diabetes, cancer, respiratory disease. But some things are more common. Dementia seems to disproportionately affect Latinos compared to other groups. And more than 50% of people of Hispanic descent will have type 2 diabetes in their lifetime compared to less than 40% for the rest of the population.

    In addition, Hispanic Americans are 1.2 times more likely to be obese than non-Hispanic whites and 1.5 times more likely to have kidney disease compared to other Americans. In addition, while Hispanics have a lower rate of some of the common cancers in the U.S., they have a higher rate of cancer caused by infectious agents such as liver, stomach, and cervical cancer.

    The higher incidence of these diseases has a lot to do with historical marginalization versus there being something inherent in Latinos that makes them more likely to have these conditions.


    Continued

    WebMD: Do people in the Latino community receive a different standard of medical care because of their race or cultural background?


    Arbaje: In some cases, yes. I see this play out in a variety of ways. The biggest challenge is a lack of access to care, which can lead to a delayed diagnosis. Dementia, for example, tends to be diagnosed later in Latinos. 

    A lack of trust in the medical community can also delay a diagnosis. This mistrust is sometimes based in disturbing history. To take one example, U.S. scientists tested the birth control pill in Puerto Rican women without their full consent.   

    Sometimes there are language barriers between doctors and aging patients and that can add to the problem. Unfortunately, the reality is that some in the medical community still look down on people of Latin descent who may not speak English as a first language.


    WebMD: Does research data focus on unique issues and health outcomes for Hispanics? 


    Arbaje: People don’t often think about how data can be skewed – especially the data currently available to us. We have a long way to go as studies and some medical data don’t give enough detail and may not reflect the real makeup of the U.S. population.

    One problem is a possible undercounting of Latinos. Nationally, most of the data about the older population comes from Medicare. But Medicare data isn’t great for identifying ethnicity, especially people of multiple ethnicities. As a result, many Hispanics are classified as “other” or “unknown.” 

    Also, in most medical record software programs people aren’t allowed to self-identify. And if they are, available options may not be accurate. 

    And many medical records systems may not account for the multiple last names common in many Latino cultures. As a result, some people may mistakenly have two more medical records, which can mean unsafe or incorrect medical care. 


    WebMD: What can someone in this population do to improve some of those health outcomes?


    Arbaje: We know nutrition is critical to health. I encourage Latinos to consider their country of origin, which likely follows a plant-based diet. If you don’t have easy access to fresh fruits and vegetables, ask for help through peers, health care professionals, or even the faith community. 


    Continued

    Of course, exercise is important for anyone as well, especially for those who are getting older. 

    I also say: Demand that the health care you receive is aligned with your goals. This may be uncomfortable for the older generations as they aren’t taught to question their doctors, but younger caregivers can help. 

    For example, if you’re a caregiver, you could say “My grandfather wants to be able to get to church on the weekends. What can we do to get that?” Or “My grandmother wants to spend more time with her grandchildren. Would these medications allow her to do this?” Present your goals clearly and directly.


    WebMD: What about the emotional health impacts faced by this community?


    Arbaje: Depression is a problem in older people, but can be hard to diagnose in the Latino community because there’s a stigma often around talking about things like depression that may imply weakness. Or I see patients who assume a low mood is a “normal” part of aging and won’t talk to their doctors about it. 

    Social isolation is a problem. It can worsen depression and hasten dementia. That’s why staying socially connected is so important as people get older. In many cases, due to immigration and migration, family support systems in Latino communities may be far away and so less able to help. Many younger people, for example, have left Puerto Rico for jobs on the U.S. mainland, leaving a lot of the aging population behind with less support. 

    That’s why finding, building, and nurturing a support system is so important.


    WebMD: Did we learn anything about the health of Latinos during the pandemic?


    Arbaje: COVID affected Latinos more than the general population – mostly younger people in the meat packing and home health care industries. And there are some long-term effects that are yet to be seen as these folks age. I think this is going to be an emerging place to watch. In some ways, COVID can accelerate some underlying diagnoses. We have yet to see what happens there.


    Continued

    WebMD: How can health care providers better serve the Latino community?


    Arbaje: Hire them! Make it a priority to improve data about the Latino community. Approach care with cultural humility. Engage in shared decision-making and meeting people where they are instead of communicating in a way that places the full blame for health challenges on the patient. 

    Yes, individual responsibility is important, but good health care is a partnership.


    WebMD: What’s your message to loved ones and caregivers of those in the aging community?


    Arbaje: To the caregivers, I say, “You are not alone.” There are people who can help make your loved one’s life match what they want it to be as best as possible. Geriatricians in particular see it as a mission to help older adults have a better quality of life. But you can also get support from other health care and mental health professionals and from your faith community and peers. 

    Lastly, know you are doing noble work. Treasure this time. It is a distinct honor and privilege to usher someone through the later stations in their life. It can be challenging, but it’s important and sacred work that has real value.



    WebMD Feature


    Sources

    SOURCE: 

    Alicia I. Arbaje, MD, MPH, PhD, associate professor of medicine, Johns Hopkins University School of Medicine; director of transitional care research, Center for Transformative Geriatrics Research, Division of Geriatric Medicine and Gerontology.



    © 2022 WebMD, LLC. All rights reserved.

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  • Esteam Health CEO Keynoting at Symposium Featuring 23 Experts on Topics Related to Arts and Health in Aging Care

    Esteam Health CEO Keynoting at Symposium Featuring 23 Experts on Topics Related to Arts and Health in Aging Care

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    Esteam Health is a private company that provides arts and health programming as a service to aging care facilities in the United States.

    Press Release


    Oct 31, 2022 08:30 EDT

    Alyssa Janney, Founder and CEO of the start-up company Esteam Health, will be keynoting at an upcoming Virtual Symposium titled: A New Methodology in Aging Care – Interdisciplinary Arts & Health Programming, on Nov. 2, 2022. 

    Esteam Health is a private company that will be launching evidence-based, interdisciplinary arts and health programming as a service to aging care facilities in 2023. Esteam Health programs have a primary goal of producing improvements in intrinsic capacity for older adults in aging care facilities. Keynoting in this virtual symposium will provide an opportunity for Janney to make the case for what makes interdisciplinary, evidence-based arts and health programming different than what is commonly available in aging care facilities now. Janney reports, “The challenge that program developers have had is that due to high turnover rates in aging care facilities, program quality and continuity can suffer. But there are also serious opportunity costs for residents who may depend upon evidence-based programming for their cognitive, social, emotional, physical and spiritual health.” 

    Alyssa Janney, MBA, has worked at the cutting-edge of the global arts and health field for 18 years. Throughout the years, she has built relationships with other top experts in the field. Esteam Health is proud to be a title sponsor for the Symposium and would like to invite anyone engaged in the business of aging care to join leading artists, academics, health experts, research scholars, aging care experts, business executives and creative arts therapists for a virtual symposium exploring the arts as a new frontier in health, aging care, and wellbeing. The symposium is being offered by the Esteam Health Foundation. (http://esteamhealthfoundation.org)

    ESTEAM HEALTH LLC

    We believe it’s time for a paradigm shift in aging care. We are innovating at the intersection of science, medicine, technology and the arts. 
    An interdisciplinary body of knowledge is building identifying opportunities to employ these discoveries in sustainable ways so that we can address some of the most challenging problems in eldercare. We know that arts experiences measurably change the body, brain, and behavior, and we are translating this knowledge into specific practices that improve intrinsic capacity, meaning lower resident dependency rates in eldercare. These benefits are expected to create a ripple effect of efficiency improvements that will transform eldercare in ways that are pleasing to insurers, healthcare providers, eldercare organizations, employees and most importantly…residents of eldercare facilities.  

    Source: Esteam Health LLC

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  • Before Natural Disasters Strike, Seniors Living Alone Need To Prepare

    Before Natural Disasters Strike, Seniors Living Alone Need To Prepare

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    The New York Times
    NYT
    profiled older storm victims facing an uncertain future after Hurricane Ian. The featured picture was an older couple with their arms around each other, comforting each other. The reporter then disclosed that the couple was unable to rebuild the lives they had enjoyed for 20-plus years in their adopted state of Florida because they didn’t have the resources to rebuild. That’s a tragedy for them and others in that same boat.

    The story went on to say that they had chosen to return to Kentucky, the far-less-expensive state from which they moved, to stay with their daughter and figure out their next steps. Sounds like a reasonable plan for them. But what about the millions of people in this country who don’t have children whose basement or garage apartment they can move into for a few months or years? What about people who don’t have a spouse with whom to share the emotional and logistical burden of rebuilding their lives?

    Solo agers, people without children or other family support, represent an increasingly large percentage of the older adult population in the United States. The childless, alone, number more than 12 million and when you add in those who are estranged from their children or live thousands of miles away, it becomes a very impressive picture in a very unsettling way.

    For a variety of reasons, retired cohorts in earlier decades included far fewer solo agers. The Baby Boomers, however — especially the later ones born between 1955 and 1964 — had more than double the rate of childlessness of all previous generations. This fact presents challenges for individuals, communities, and government services.

    One of the biggest challenges for individuals who consider themselves solo agers is developing a backup plan. No one likes to think about disaster striking where they live, but we live in turbulent times and natural disasters are becoming more and more common. If you consider yourself to be a solo ager, it’s important to take a realistic look at the kind of disaster that might happen in your area. In my own area it’s fire. Other parts of the country are threatened by tornadoes, hurricanes, flooding, or earthquakes.

    The Centers for Disease Control and Prevention recommends that all older adults create an emergency preparedness plan, and recommends taking the following measures:

    • Choose a contact person who will check on you during a disaster, and decide how you will communicate with each other (for instance, by telephone or knocking on doors). Consider speaking with your neighbors about developing a check-in system together.
    • Create a list of contact information for family members and friends. Leave a copy by your phone(s) and include one in your emergency supply kit.
    • Plan how you will leave and where you will go during an evacuation. If you are living in a retirement or assisted living community, learn what procedures are in place in case of emergencies. Keep a copy of exit routes and meeting places in an easy-to-reach place.
    • If you have medical, transportation, or other access needs during an emergency, consider signing up for SMART911, Code Red, or your local county registry, depending upon which service your area uses to helps first responders identify people who may need assistance right away.

    These days, most people rely on their cell phones, so make sure you have your ICE (in case of emergency) contact prominently displayed on your phone. You may even want to create a separate contact entry just for this purpose.

    One other preparatory action you might want to consider is creating a reciprocal shelter plan with a friend in a different geographic location. Here is an example: Jeanne lives in an area of Oklahoma considered to be part of “tornado alley.” Like most people in the area, she has a storm shelter, but Jeanne fears the day may come when she will emerge from the storm cellar to find that her home had been destroyed by the tornado.

    Jeanne’s friend, Alice, lives in Galveston, Texas which, being a coastal city, is vulnerable to hurricanes. Jeanne and Alice know each other from their college days, are both single solo agers and have become “shelter partners,” each agreeing to house the other for up to two years following a catastrophe which makes either of their homes unlivable. The statistical chances of either of these women becoming homeless because of a major catastrophe are quite slim, of course. But it does happen to thousands of people every year, so they have wisely chosen to be prepared.

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    Sara Zeff Geber, PhD, Contributor

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  • TSOLife Closes Series A Funding to Provide Senior Living Operators More Advanced Decision-Making Tools

    TSOLife Closes Series A Funding to Provide Senior Living Operators More Advanced Decision-Making Tools

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    Press Release


    Oct 18, 2022

    TSOLifeInc., the only AI-based business intelligence platform that translates resident intake data into actionable insights that help communities create individualized experiences, announced today that it completed a $9 million Series A funding round. Arnie Whitman, a long-time venture investor in senior care and technology, Executive Chairman at Formation Capital and Founding Partner at Generator Ventures led the round to help accelerate the development of TSOLife’s next-generation Minerva platform. Omega Healthcare Investors, Inc. and Ziegler Link-age Fund III joined the round as well.  

    TSOLife has already achieved significant milestones, partnering with some of the largest operators in the industry. “The pandemic fueled the understanding that engagement and resident experience is vital to the physical and mental health of residents and the success of a community,” said David Sawyer, the Founder and Chief Executive Officer of TSOLife. “This funding round will accelerate our ability to enhance the lives of seniors by leveraging data to provide robust resident insight technology unique to TSOLife. We have a passion for bringing state-of-the-art-tech to the market, while never forgetting that our goal is to improve the lives of residents and staff.”  

    TSOLife Minerva is the first-of-its kind business intelligence platform that uses Artificial Intelligence (AI) to transcribe resident interviews and automatically convert the information into organized, consumable data. This person-centered data fuels powerful dashboards providing staff with personal, actionable insights and saves valuable staff time.  

    “TSOLife improves staff efficiency not by demanding more, but by eliminating time-consuming tasks, which is a win-win for providers,” said Katie Schmitz, Chief Administrative Officer of the Ziegler Link-age Fund III. “The platform allows staff to spend more time doing what they love – engaging with residents!” The next generation of the Minerva platform will leverage care-level-specific engagement data to help increasingly tech-savvy seniors self-select their own experience and take more control of their overall health and well-being.

    “TSO is the tip of the spear in gathering social insights to improve quality of life and relationships in a unique and powerful way,” said Arnie Whitman, lead investor. “Data and AI will allow for more personalization and better social and health outcomes. Everyone talks about social determinants; TSO actually measures it!” Visit www.tsolife.com for more information.

    About TSOLife, Inc.

    TSOLife partners with senior living communities across the nation to provide a first-of-its-kind business intelligence platform using Artificial Intelligence (AI) called Minerva. Minerva creates powerful dashboards with a suite of information and personalized tools for staff to put prospect and resident knowledge into practice. TSOLife provides actionable insights and fuels decision-making in senior living communities. Visit www.tsolife.com for more information.

    About Omega Healthcare Investors, Inc.

    Omega is a REIT that invests in the long-term healthcare industry, primarily in skilled nursing and assisted living facilities. Its portfolio of assets is operated by a diverse group of healthcare companies, predominantly in a triple-net lease structure. The assets span all regions within the U.S., as well as in the United Kingdom.

    About Ziegler Link-Age Fund III, LP

    Ziegler Link-Age Fund III is the third fund managed by a joint venture between Ziegler (www.ziegler.com) and Link-Age (www.LinkageConnect.com) that seeks to support emerging companies operating in or developing businesses focused on aging and related care. The Fund’s investments align with the goals of its limited partner investors who consist primarily of organizations across the senior living and care, healthcare, and aging services landscape that have a significant interest in finding innovative solutions to improve the independence, quality and cost of care, and overall lives of the aging population.

    Source: TSOLife

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  • Age vs. genetics: Which is more important for determining how we age?

    Age vs. genetics: Which is more important for determining how we age?

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    Newswise — Amid much speculation and research about how our genetics affect the way we age, a University of California, Berkeley, study now shows that individual differences in our DNA matter less as we get older and become prone to diseases of aging, such as diabetes and cancer.

    In a study of the relative effects of genetics, aging and the environment on how some 20,000 human genes are expressed, the researchers found that aging and environment are far more important than genetic variation in affecting the expression profiles of many of our genes as we get older. The level at which genes are expressed — that is, ratcheted up or down in activity — determines everything from our hormone levels and metabolism to the mobilization of enzymes that repair the body.

    “How do your genetics — what you got from your sperm donor and your egg donor and your evolutionary history — influence who you are, your phenotype, such as your height, your weight, whether or not you have heart disease?” said Peter Sudmant, UC Berkeley assistant professor of integrative biology and a member of the campus’s Center for Computational Biology. “There’s been a huge amount of work done in human genetics to understand how genes are turned on and off by human genetic variation. Our project came about by asking, ‘How is that influenced by an individual’s age?’ And the first result we found was that your genetics actually matter less the older you get.”

    In other words, while our individual genetic makeup can help predict gene expression when we are younger, it is less useful in predicting which genes are ramped up or down when we’re older — in this study, older than 55 years. Identical twins, for example, have the same set of genes, but as they age, their gene expression profiles diverge, meaning that twins can age much differently from each other.

    The findings have implications for efforts to correlate diseases of aging with genetic variation in humans, Sudmant said. Such studies should perhaps focus less on genetic variants that impact gene expression when pursuing drug targets.

    “Almost all human common diseases are diseases of aging: Alzheimer’s, cancers, heart disease, diabetes. All of these diseases increase their prevalence with age,” he said. “Massive amounts of public resources have gone into identifying genetic variants that predispose you to these diseases. What our study is showing is that, well, actually, as you get older, genes kind of matter less for your gene expression. And so, perhaps, we need to be mindful of that when we’re trying to identify the causes of these diseases of aging.”

    Sudmant and his colleagues reported their results this week in the journal Nature Communications.

    Medawar’s hypothesis

    The findings are in line with Medawar’s hypothesis: Genes that are turned on when we are young are more constrained by evolution because they are critical to making sure we survive to reproduce, while genes expressed after we reach reproductive age are under less evolutionary pressure. So, one would expect a lot more variation in how genes are expressed later in life.

    “We’re all aging in different ways,” Sudmant said. “While young individuals are closer together in terms of gene expression patterns, older individuals are further apart. It’s like a drift through time as gene expression patterns become more and more erratic.”

    This study is the first to look at both aging and gene expression across such a wide variety of tissues and individuals, Sudmant said. He and his colleagues built a statistical model to assess the relative roles of genetics and aging in 27 different human tissues from nearly 1,000 individuals and found that the impact of aging varies widely — more than twentyfold — among tissues.

    “Across all the tissues in your body, genetics matters about the same amount. It doesn’t seem like it plays more of a role in one tissue or another tissue,” he said. “But aging is vastly different between different tissues. In your blood, colon, arteries, esophagus, fat tissue, age plays a much stronger role than your genetics in driving your gene expression patterns.”

    Sudmant and colleagues also found that Medawar’s hypothesis does not hold true for all tissues. Surprisingly, in five types of tissues, evolutionary important genes were expressed at higher levels in older individuals.

    “From an evolutionary perspective, it is counterintuitive that these genes should be getting turned on, until you take a close look at these tissues,” Sudmant said. These five tissues happen to be the ones that constantly turn over throughout our lifespan and also produce the most cancers. Every time these tissues replace themselves, they risk creating a genetic mutation that can lead to disease.

    “I guess this tells us a little bit about the limits of evolution,” he said. “Your blood, for instance, always has to proliferate for you to live, and so these super-conserved, very important genes have to be turned on late in life. This is problematic because it means that those genes are going to be susceptible to getting somatic mutations and getting turned on forever in a bad, cancerous way. So, it kind of gives us a little bit of a perspective on what the limitations of living are like. It puts bounds on our ability to keep living.”

    Sudmant noted that the study indirectly indicates the effect on aging of one’s environment, which is the impact of everything other than age and genetics: the air we breathe, the water we drink, the food we eat, but also our levels of physical exercise. Environment amounts to up to a third of gene expression changes with age.

    Sudmant is conducting similar analyses of the expressed genes in several other organisms — bats and mice — to see how they differ and whether the differences are related to these animals’ different lifespans.

    UC Berkeley graduate students Ryo Yamamoto and Ryan Chung are co-first authors of the paper. Other co-authors are Juan Manuel Vazquez, Huanjie Sheng, Philippa Steinberg and Nilah Ioannidis. The work was supported by the National Institute of General Medical Sciences (R35GM142916) of the National Institutes of Health.

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    University of California, Berkeley

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  • Yes, coffee can help you live longer and protect you from cardiovascular disease, with a few caveats

    Yes, coffee can help you live longer and protect you from cardiovascular disease, with a few caveats

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    Coffee is one of the world’s most popular beverages. Here in the United States and in 17 other countries, September 29th is celebrated as National Coffee Day. For the rest of the world, October 1st is International Coffee Day.  It is all about celebrating a love of the caffeinated beverage made from the beans of the tropical evergreen coffee plant and paying respect to the world’s coffee farmers. 

    The possible health benefits of coffee have been percolating in the news for years: Coffee can lower your risk for diabetes, coffee may protect against disease and even some cancers. More recently, headlines claim that coffee can extend your life or reduce cardiovascular disease risk. Good news, coffee lovers. The claim is mostly true.   

    New research showed that people that drank two to three cups of coffee a day appear to live longer. The study also found that there was a reduced risk of cardiovascular disease. All types of coffee, including ground, instant, and decaf, appeared to provide this health benefit. The research was published on September 27, 2022, in the European Journal of Preventive Cardiology

    Maya Vadivloo backs the claim that coffee is good for you, with some caveats. She is the Associate Professor and Director in Health Sciences Department of Nutrition and Food Sciences at the University of Rhode Island. Vadivloo is an expert on nutrition, appearing often on such outlets as Today.com.

    “Based on existing evidence, I would say it is mostly true that coffee consumption appears to protect against cardiovascular and total mortality, with a few caveats.  I believe evidence remains inconclusive about intake >5 cups/day and that the method of preparation may matter, with some question about whether compounds released when boiling coffee (vs. drip or similar methods) may be less favorable (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524812/).”

    For those who don’t drink our coffee black, are the benefits still there after we add flavorings such as sugar or cream? “The addition of milk etc. to coffee does not eliminate all health benefits,” says Vadiveloo.  “However, in line with other recommendations for a healthy dietary pattern, limiting forms of added sugar and replacing high-fat dairy with low-fat products would be better for health outcomes and energy balance.”

    Is coffee the magic bullet that will help us live longer, healthier lives? Not quite, says Vadiveloo.

    “While I love coffee, I am always cautious of media coverage that suggests there is some ‘magic bullet’ to improve mortality. While I believe there is compelling evidence that 2-3 cups (or even <5 cups of coffee) have cardioprotective and mortality benefits, it’s not a recommendation that exists in isolation.  Regular coffee consumption when part of a heart-healthy diet rich in minimally processed fruits, vegetables, healthy sources of protein (mostly plant sources like nuts and legumes, seafood, and fish), whole grains, heart-healthy vegetable oils, and limited in added sugars, salt, and high fat meats as advocated by the recent American Heart Association dietary guidance (https://www.ahajournals.org/doi/10.1161/CIR.0000000000001031) is the secret to improving overall health and mortality. (**disclaimer, I was a part of the AHA writing group)

    So I would say, if people enjoy coffee, they should continue to do so as part of a healthy dietary pattern, and to be mindful of what things they add to their coffee to maximize the health benefits.  And further, if people want to replace less healthy beverages in their diet (e.g., sodas and fruit juices) with coffee, that would be a positive step.”

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    Newswise

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  • Breast Cancer Screening: Understanding Risk and Age

    Breast Cancer Screening: Understanding Risk and Age

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    Newswise — New Brunswick, N.J., October 1, 2022 – Aside from skin cancer, breast cancer is the most commonly diagnosed cancer in women in the United States and will result in an estimated 43,250 deaths in the nation this year, according to the American Cancer Society. The most effective screening tool for breast cancer is a mammogram, which uses low dose X-rays to create images of the breast. This method can find breast cancer before there are any signs or symptoms, and before the cancer grows larger or spreads to other parts of the body. Fortunately, when breast cancer is detected early, it is easier and more successful to treat, which is why all women should learn about screening regardless of their age. 

    Risk of developing breast cancer increases as you get older. The two most significant risk factors for developing breast cancer include being a woman and increasing age, however, there are other factors that may increase your risk. You may also be at high risk if you have a mother or sister who developed breast or ovarian cancer or if you have multiple family members who developed breast, ovarian or prostate cancer. According to the American Cancer Society, breast cancer mainly occurs in middle-aged and older women, with a median age at the time of diagnosis at 62.

    Women over 70 are still at risk of breast cancer. It is generally recommended that women begin getting a mammogram at age 40 annually. For women aged 50 to 74 years, The United States Preventative Services Task Force (USPSTF) recommends concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening mammography in women aged 75 years or older. The American Cancer Society advises physicians to continue screening patients as long as they are in “good overall health” and have a life expectancy of 10 year or longer.

    All women should pay attention to breast cancer warning signs. Early disease usually does not cause pain. As the cancer grows, symptoms may include a lump or thickening in or near the breast or in the underarm area, change in the size or shape of the breast, or tenderness. Other symptoms include nipple discharge or the nipple pulled back into the breast, or a change in the way the skin of the breast, areola, or nipple looks or feels (warm, swollen, red, or scaly).

    Early detection saves lives. If you are unsure about breast cancer screening recommendations for your personal situation, discuss with your doctor to make a decision that feels right for you. Learn more at rwjbh.org/mammo.

    Michele Blackwood, MD, FACS, is Chief, Section of Breast Surgery at Rutgers Cancer Institute of New Jersey, the state’s leading cancer center and  only National Cancer Institute-Designated Comprehensive Cancer Center and Medical Director, Northern Regional Director of Breast Services at  RWJBarnabas Health.

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    Rutgers Cancer Institute of New Jersey

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  • NHCOA to Host Virtual ‘Caring for the Caregiver During the Pandemic’ Training

    NHCOA to Host Virtual ‘Caring for the Caregiver During the Pandemic’ Training

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    Press Release


    Jul 12, 2022

    The National Hispanic Council on Aging (NHCOA) remains committed to its mission of empowering Hispanic older adults, their families, and caregivers. One of its key focal points for 2022 and beyond is advocating for the caregivers who do so much for aging and ailing loved ones. Providing quality care for their care recipient is only one of the many invaluable duties they perform tirelessly every day; within this new inhabited reality due to the COVID-19 pandemic, it is vital that caregivers recognize the importance of self-care, mental health, and taking advantage of the resources available to them.

    To help support and educate caregivers, on Saturday, July 16, 2022, NHCOA will be holding a one-day virtual training titled “Caregiving Training: Caring for the Caregiver during the Pandemic.” This training (conducted in Spanish) will focus on providing caregivers with the tools and resources they need to overcome caregiving challenges, including those imposed on them by the COVID-19 pandemic. The training will also emphasize the importance of practicing self-care habits, recognizing one’s role as a caregiver, and understanding what that role entails. As part of the training, there will be a discussion surrounding approaches to maintaining the caregiver’s mental, emotional, and physical health.

    The “Caring for the Caregiver during the Pandemic” training is sponsored by our friends at AARP. “Caregivers are the backbones of America’s care system, providing the bulk of care for older people in the U.S. as they strive to live independently. Caregiving can be an all-consuming experience that leaves the caregiver exhausted and lonely – that’s why AARP is proud to support this initiative led by NHCOA to provide mental health resources for caregivers,” said Yvette Peña, Vice President of Audience Strategy, Office of Diversity Equity & Inclusion at AARP.

    Spaces for this training will be limited, so be sure to contact Christine S. Perez at c.perez@nhcoa.org or research@nhcoa.org to ensure a spot.

    NHCOA’s Caregiving Training: Caring for the Caregiver during the Pandemic

    WHEN: July 16, 1 p.m. (EDT)

    WHERE: via Zoom RSVP: contact Christine S. Perez at c.perez@nhcoa.org or research@nhcoa.org. Or contact NHCOA at 202-658-8664 (via WhatsApp) and 202-347-9733.

    About the National Hispanic Council on Aging (NHCOA): NHCOA is the leading national organization working to improve the lives of Hispanic older adults, their families, and their caregivers. Headquartered in Washington, D.C., NHCOA has been a strong voice dedicated to promoting, educating, and advocating for research, policy, and practice in the areas of economic security, health, and housing for Hispanic older adults, families, and caregivers for more than 50 years. For more information about NHCOA, call 202-347-9733 or visit www.NHCOA.org.

    About AARP: AARP is the nation’s largest nonprofit, nonpartisan organization dedicated to empowering people 50 and older to choose how they live as they age. With a nationwide presence and nearly 38 million members, AARP strengthens communities and advocates for what matters most to families: health security, financial stability and personal fulfillment. AARP also produces the nation’s largest circulation publications: AARP The Magazine and AARP Bulletin. To learn more, visit www.aarp.org, www.aarp.org/espanol or follow @AARP, @AARPenEspanol and @AARPadvocates, @AliadosAdelante on social media.

    Source: NHCOA

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  • NHCOA Joins AARP With the Virtual Campaign Caring for the Caregiver

    NHCOA Joins AARP With the Virtual Campaign Caring for the Caregiver

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    Press Release



    updated: May 4, 2022

    NHCOA is launching an online campaign dedicated to bringing awareness about caring for the caregiver sponsored by AARP. Being a caregiver can be very rewarding, but it can also be stressful. Caregivers not only have to take charge of looking after their loved ones but also need to upkeep their personal lives; it can be an overwhelming way of life. But as a very important role in society, it is extremely crucial for caregivers to practice day-to-day activities that will help them to maintain a healthy mindset.

    Caregivers need to be mentally and physically healthy in order to be able to assist those who need their help. Family and professional caregivers need to be aware of their own health, and self-care and be mindful to not put their well-being at risk. The combination of loss, prolonged stress, the physical demands of caregiving, and the biological vulnerabilities that come with age can place one at risk for significant health problems as well as early death.

    The importance of the campaign is to ensure that caregivers can recognize themselves as an essential part of the field and that they need to care for themselves with the same diligence as they care for others. Through the virtual campaign, they can find resources and tools to keep themselves mentally and physically healthy,” states Dr. Yanira Cruz, President and CEO of NHCOA.

    As Latinos, caring for family and friends is one of life’s greatest honors,” says Yvette Peña, Vice President in the Office of Diversity, Equity and Inclusion at AARP. “It’s also one of life’s greatest responsibilities. AARP is proud to work with NHCOA to make sure caregivers feel supported in their role by equipping them with the resources, knowledge, and plans they need to look after those they love.

    Faced with the urgent need to make caregivers aware of the importance of caring for their own health with the same attention they give to their loved one’s health, NHCOA has partnered with AARP to create an online campaign titled “Caring for the Caregiver.” The digital campaign consists of social media posts and articles that will be published on NHCOA’s social channels. Follow the campaign on our social media to learn more about this project and see important information for taking care of caregivers.

    About the National Hispanic Council on Aging (NHCOA): NHCOA is the leading national organization working to improve the lives of Hispanic older adults, their families and their caregivers. Headquartered in Washington, D.C., NHCOA has been a strong voice dedicated to promoting, educating, and advocating for research, policy, and practice in the areas of economic security, health, and housing for Hispanic older adults, families, and caregivers for more than 50 years.

    About AARP: AARP is the nation’s largest nonprofit, nonpartisan organization dedicated to empowering people 50 and older to choose how they live as they age. With a nationwide presence and nearly 38 million members, AARP strengthens communities and advocates for what matters most to families: health security, financial stability and personal fulfillment. AARP also produces the nation’s largest circulation publications: AARP The Magazine and AARP Bulletin. To learn more, visit www.aarp.org, www.aarp.org/espanol or follow @AARP, @AARPenEspanol and @AARPadvocates, @AliadosAdelante on social media.

    ——————————————-

    Contact: Marcela Martínez

    Company: National Hispanic Council on Aging (NHCOA)

    Phone: 202-347-9733

    Email: publicrelations@nhcoa.org

    Web: www.nhcoa.org

    Twitter, Facebook, Instagram: @NHCOA

    Source: NHCOA

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  • Doctors Open Medical Spa With Focus on Overall Wellness and Aesthetic Services

    Doctors Open Medical Spa With Focus on Overall Wellness and Aesthetic Services

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    Press Release



    updated: Mar 21, 2019

    It’s a beautiful spa feeling with a traditional take on medicine. Two physicians, Neurosurgeon Robert S. Davis, MD, and Internal Medicine Physician Hema Edupuganti, MD, are looking forward to opening Nūr Medical Spa on March 25 and expanding their medical practices to include unique healing options.

    The ultimate focus of the spa will be total wellness including body improvement through weight loss and lifestyle changes as well as anti-aging treatments and bioidentical hormone replacement therapy. Every service is designed to make women and men feel their most healthy.

    Drs. Davis and Edupuganti are excited to offer minimally invasive cosmetic procedures that will make clients look and feel better. “People can look great at any age,” says Dr. Davis. “I want them to look how they feel and have personalized care. We will really take time with our patients to understand their unique beauty and wellness concerns.”

    Nūr Medical Spa will offer other luxurious services as well, including facials, Botox treatments and dermal fillers, chemical peels, hair removal, skin tightening, UltraShape, and VelaShape. More services will be added at a later date, and all will focus on beauty and wellness.

    “This has been my dream for years,” Dr. Edupuganti says. “I want women and men to improve their confidence and self-esteem. This will allow them to think positively about themselves and enjoy their lives that much more.”

    The spa will offer 40 percent off laser treatments for any appointment booked from now to March 29. Customers may schedule the service to occur after those dates, but the appointment must be made within that date range to qualify for special pricing. Laser services include hair removal, laser skin tightening, laser spider vein treatment, laser facials and Intense Pulsed Light (IPL). All laser services at Nūr are to be performed with the most technologically advanced lasers available, providing their clients with fewer treatments and minimal discomfort.

    Located at 4309 Bluebonnet Boulevard, Nūr Medical Spa is now accepting appointments. Call (225) 255-2963 to schedule your first appointment.

    Source: Nūr Medical Spa

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  • Empty Nesters Capturing Their Second Life With Action, Connections, and Tools

    Empty Nesters Capturing Their Second Life With Action, Connections, and Tools

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    Mastering The Empty Nest is a National movement launched by conflict expert and mediator, Karleen Andresen, for the 35+ parent crowd, also known as, empty nesters.

    ​​​​​​​​​​​​​As young adult children leave the proverbial bed of roses, some parents appear to move on without a hitch; however, contrary to appearances, this substantial crowd is realizing a loneliness left in the wake. An increase in divorce among the empty nest is being recognized by religious groups to entertainment websites, and conflict resource tools are Andresen’s answer, “…because I have seen it work repeatedly.”

    Conflict experts, like mediators, are brought into a court situation in the eleventh hour, when it’s time to divide assets. “It’s like the hospice for families and couples because it’s where relationships go to die” says Andresen. Yet, Andresen can attest that if empty nesters gain the necessary tools earlier, “There are many relationships that could be redeemed or rescued.”

    According to WSJ and others there has been an increase of divorce among the empty nester crowd; however, Andresen says, “…using mediation or conflict tools, there are many relationships that could be redeemed or rescued.”

    Karleen Andresen, Owner/CEO

    “People don’t get married or live together to get divorced. Behind every long lasting relationship are smaller tasks at work, and every bit of effort has needs and required tools to make it successful” Andresen says, “Knowledge, connection, a place to commiserate, a judge free zone, and tools can help them choose their terms. Andresen is not absent of reality, “Divorce can still come, but imagine it happening because it was their decision and not a knee jerk reaction to their loss.” She also says when it’s a thoughtful choice between people, there is more peace and wholeness present.

    Mastering the Empty Nest is for pre-empty nest and empty nest age adults and provides free resources for those looking to recapture their “second life.” The site provides free information, a networking channel to ask and receive answers to questions, online webinars on how to navigate the changes that happen, a membership program, one-on-one consulting, and conferences to build a new life plan as couples or individuals.

    An article is included for your use and publication as you see fit.

    ###

    1 POWERFUL TIP FOR EMPTY NESTERS TO STEER CLEAR OF THE AFTER CHRISTMAS CRASH – so powerful it will become a new tradition

    written by: Karleen Andresen

    Long awaited homecomings, late night visits, and traditional pecking and hen pecking is all part of the holiday legacy experienced between November 1 to January 2 each and every season. Like the sun rising and setting, this period of time is fraught with frenzy and tension, but beloved and expected. However, darker days lay ahead for empty nesters especially after Christmas.

    Without immediate re-engagement, empty nesters can be lulled into a reminiscent depression or isolation creating an emotional crash after Christmas. This can come almost immediately, or after the dishes are finished and the tree is at the curb. It can also show up weeks later as the calendar and shopping list have fewer entries.

    For empty nesters, Christmas is a highly anticipated event. There is the pre-baking, special dishes prepared for each family member, thoughtful gifts, wrapping paper and ribbons, wiping down the stemware to be spot free, polishing of the silver, and making sure you know your store hours for last minute required dashes.

    The after Christmas crash is not easy, but gleaning from experience and training, this single tip could help an empty nester land on their feet. When I created this in my life, it was so enjoyed that it has became a tradition. This is geared for couples, but can easily be modified for single empty nesters to do with friends.

    Plan and follow through with an activity for the two of you on the same day as the house empties

    The day everyone leaves is the day you should have your next activity with your companion. Doing so will give you something to anticipate and talk about as the children are packing up to leave. I remember an aunt and uncle left my Grandmother’s home on Christmas day for their gift to each other: a trip to Venice. As a young girl, it was delightful to watch the anxiety while everyone helped them pack, to listen to everyone speculate about their trip, and soak up the energy that surrounded them. Planning something the same day as departure also comes with some of the same frenzy as my aunt and uncles trip. Finally, make this plan equally important to planning for the arrival of the extended family or leaving on that jet plane.

    If you’re not sure what to do, consider attending a champagne brunch, strolling an outdoor or indoor mall, take a long drive and just stop at a local cafe and absorb the experience, or even spend a couple hours at a local McDonald’s. You might take a trip because airlines usually participate in Black Friday sales that can last for weeks. Maybe you dine at an expensive restaurant or visit people at an assisted living facility. Perhaps you want to look at babies at the local hospital or shut yourself in at a fine hotel overnight. Really, the choice is yours to plan, but it must be planned, expected, and treated as something you are gifting. The finale? Adding a few guidelines will be the icing to a warm event. 

    Here are five guidelines to really add the nuances needed to make an empty nester forget their woes.

    • Gauge The Activity Toward The Schedule Ahead – For example, if you only have a few hours then plan something that fits within that timeframe. If you have the ability to spend a day or overnight, pull out the stops and extend the holiday celebration.
       
    • Forget The Clean Up – If you haven’t quite gotten the house back in order, don’t worry, the work will not clean itself. It will be there when you return. 
       
    • Get Dressed Up – It can be cumbersome to think about, but just like the effort made for the children, make the same effort for yourselves.
       
    • Conversation Starters – Talk about the best experiences of the holidays, the most growth you noticed in each of the family members, what you noticed about each other during the season, and how you will walk into the future together.
       
    • Hold Hands – This is so powerful that it requires announcing it. Touch is a necessity, and as empty nesters this can be a forgotten technique if not reminded.

    It is a sobering time when you realize there are no more high demands on your time, no more hems to sew, no more scraped knees to kiss, and no more graduation invitations that need to be sent, but with a little help and openness, you can make a new tradition your best yet.

    Karleen Andresen is a conflict expert dealing with legal cases and high conflict personalities. She runs an online community of empty nesters seeking connection and tools to navigate the terrain of living their second life. Prior, Andresen grew a women in business magazine to be the #1 in her State and published From Mystery to Math Formula: Simple equations to build your business; available on Amazon. Join her at www.MasteringTheEmptyNest.com 

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