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Fonda couldn’t help but laugh while admitting the shamefully superficial reason she’d only date someone 20 or younger.
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Fonda couldn’t help but laugh while admitting the shamefully superficial reason she’d only date someone 20 or younger.
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Newswise — More older Americans use cannabis now than before the pandemic, with 12% saying they’ve consumed a THC-containing substance in the past year and 4% saying they do so multiple times a week, according to a new study of people aged 50 to 80. Those who drink alcohol at risky levels have a much higher rate of cannabis use.
The new findings, published in the journal Cannabis and Cannabinoids Research by a team from the University of Michigan’s Institute for Healthcare Policy and Innovation, suggest a need for more education and screening of older adults for cannabis-related risks.
“As the stress of the pandemic and the increased legalization of cannabis by states converged, our findings suggest cannabis use increased among older adults nationally. Older adults represent a vulnerable age group for cannabis use due to interactions with medications, risky driving, cannabis-related mental health impacts and increased possibility of falls and memory issues,” said Anne Fernandez, Ph.D., an addiction psychologist in the U-M Addiction Center and Department of Psychiatry who led the study.
The data in the study come from the National Poll on Healthy Aging, which IHPI runs with funding from AARP and Michigan Medicine, U-M’s academic medical center. The national poll of 2,023 older adults was taken in January 2021, nine months into the official pandemic declaration and just as the first COVID-19 vaccines were being made available to the groups at the highest risk.
The 12% overall past-year use of cannabis seen in the new study is higher than the 9.5% seen in 2019 by other researchers pre-pandemic, and far higher than the 3% seen in another study in 2006, when only 12 states had passed medical cannabis laws. The NPHA in 2017 found that 6% of older adults had used cannabis for medical purposes.
In the new study, in addition to the 4% who said they use cannabis products four or more times a week, another 5% said they use cannabis once a month or less. The poll question asked about use of any product containing THC, the main psychoactive component of cannabis — including edibles – and used multiple common names for cannabis. It did not differentiate between medical and recreational use of cannabis.
Older adults who said they were unemployed, those who said they were unmarried and had no partner, and those who said they drank alcohol were more likely to say they used cannabis.
Fernandez notes an especially concerning finding: those whose alcohol use was high enough to cause physical and psychological harms were nearly eight times as likely to say they had used cannabis in the past year. But even those with low-risk alcohol drinking patterns were more than twice as likely to say they had used cannabis in the past year.
This group of dual-substance users is one that doctors and public health officials should pay special attention to, she said.
“Other research has shown that using both alcohol and cannabis increases the chance that a person will drive while impaired,” she explained. “They are also more likely to have physical and mental health issues, including substance use disorders. Screening for alcohol use, cannabis use, and other drug use could help more people get counseling and reduce their risk and risk to others.”
While there were no statistical differences among older adults by age, health or mental health status, income or education, those who said they had Hispanic backgrounds were less likely than non-Hispanic older adults to say they used cannabis. Fernandez says this is consistent with other research showing lower cannabis use in the Latino community.
She advises any older adult who chooses to use cannabis products for any reason to be open with their health care provider about it, especially if they also drink alcohol or take certain medications. Physicians, nurse practitioners and pharmacists can advise if any medications a person is taking might interact with cannabis, including ones for insomnia, depression and anxiety, opioid-containing pain medications, seizure medications, and blood thinners.
For more about the poll methodology, see https://www.healthyagingpoll.org/survey-methods
In addition to Fernandez, the study’s authors are U-M addiction psychologist Lara Coughlin, Ph.D., poll deputy director Erica S. Solway, Ph.D., poll manager Dianne C. Singer, poll director Jeffrey T. Kullgren, M.D., M.S., M.P.H., poll data lead Matthias Kirch, M.S. and Preeti N. Malani, M.D., former poll director and current poll senior advisor.
In addition to the poll funding, Fernandez has research funding from the National Institute of Alcohol Abuse and Alcoholism (AA023869).
Prevalence and Frequency of Cannabis Use Among Adults Ages 50–80 in the United States, Cannabis and Cannabinoid Research, DOI: 10.1089/can.2023.0056 https://doi-org.proxy.lib.umich.edu/10.1089/can.2023.0056
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Michigan Medicine – University of Michigan
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U.S. women are now projected to live about six years longer than U.S. men, as COVID-19 and drug overdoses claim more male than female lives, according to research published Nov. 13 in JAMA Internal Medicine.
Overall U.S. life expectancy has declined in recent years and, as of the latest estimate, sits at around 76 years. But as the new research details, women are expected to live significantly longer than men. As of 2021, the latest year with federal data available, life expectancy among U.S. men was 73.5 years, compared to 79.3 years among women.
Across the world, women tend to live longer than men for a variety of reasons, some biological—such as hormonal differences—and some behavioral. Women tend to visit doctors more frequently and are less likely to smoke and drink excessively, for example. That’s been true in the U.S. for a long time. But the 2021 data represent the largest gender-based life expectancy gap in the U.S. since 1996.
The gulf began to widen before the COVID-19 pandemic, the authors note, but the trend accelerated from 2019 to 2021. Deaths from COVID-19 and unintentional injuries, a category that includes accidental drug overdoses, were the largest contributors to the widening of the gap, but differential rates of homicide, heart disease, and suicide deaths also played a role, according to the report. It’s well-established that men die of these causes more frequently than women, and in recent years, they have been some of the most common causes of death overall. Heart disease, COVID-19, and unintentional injuries accounted for three of the top five in 2021.
The gender gap would have been even wider, the authors note, but for factors including increases in maternal mortality and decreases in cancer deaths among men.
Overall, the data underscore the continued importance of limiting COVID-19’s spread, and of finding better ways to improve national mental health and prevent drug overdoses and suicides—fatalities sometimes labeled by experts as “deaths of despair.”
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Jamie Ducharme
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Newswise — (Baltimore, MD) – Carlos Ince, M.D., FACC, board certified in Adult Cardiovascular Disease, and M. Kate Elfrey, D.O., board certified by the American Osteopathic Board in Cardiology and Internal Medicine, are the featured guests on Mercy Medical Center’s monthly talk show, “Medoscopy,” airing Wednesday and Thursday, Nov. 15th and 16th at 5:30 p.m. EST (www.facebook.com/MercyMedicalCenter).
Both Drs. Ince and Elfrey see patients at The Heart Center at Mercy, which specializes in the diagnosis, treatment and prevention of heart disease including coronary artery disease (CAD), heart attack and high blood pressure.
A 30-minute pre-taped program exploring the background and lives of Mercy clinicians, patients and others, Medoscopy was launched in spring 2021 and airs in two 15-minute segments. To view past episodes, visit the Medoscopy playlist on the Mercy Medical Center YOUTUBE channel.
Dr. Ince explained his work with the Association of Black Cardiologists and efforts to address the ongoing issue of racial disparity in medicine. Dr. Elfrey noted how medicine for her is a family affairs, as her father, Stephen J. Plantholt, M.D., FACC, is not only a cardiologist as well, but is her colleague at The Heart Center at Mercy.
Medoscopy is filmed on the campus of Mercy Medical Center in downtown Baltimore with video, sound, and lighting by Zinnia Film.
Founded in 1874 by the Sisters of Mercy, Mercy Medical Center is located in downtown Baltimore City, about six blocks from Baltimore’s famed Inner Harbor. A university-affiliated teaching facility, Mercy is a Catholic hospital with a national reputation for women’s health care, orthopedics, and other specialties. Mercy is home to the renowned Weinberg Center for Women’s Health & Medicine, and the $400+ million Mary Catherine Bunting Center. For more information, visit www.mdmercy.com, and MDMercyMedia on Facebook and Twitter, or call 1-800-M.D.-Mercy.
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Mercy Medical Center
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Anti-aging expert Bryan Johnson is tired of self-proclaimed hustlers who pride themselves on getting little to no sleep.
The centi-millionaire and founder of Blueprint, a health and wellbeing organization studying age biohacking, claims to be the best person in the world at sleeping.
And having seen firsthand how many high fliers deny themselves rest—Johnson was the founder of Braintree which was bought by PayPal in 2013 for $800 million—he’s calling time on the widespread practice.
The phenomenon of successful individuals priding themselves on a lack of sleep is well known.
Elon Musk, the CEO of Tesla and owner of X—formerly known as Twitter—says he often sleeps in his office or on sofas in secluded corners of company headquarters.
Likewise Microsoft co-founder Bill Gates said he used to compete with peers to sleep as little as possible, hinting at an underlying judgment if an individual gets a good night’s sleep.
More recently Peter Brown, CEO of investment management firm Renaissance Technologies, said he’s spent some 2,000 nights sleeping in his office—and even offered an employee a pay rise for picking up the phone in the middle of the night.
Gates has since said he’s realized the error of his ways, and Johnson agrees.
The 46-year-old entrepreneur, who is trying to reverse his age to 18, told the Diary of a CEO podcast he goes to sleep at 8.30 pm every night, having eaten his last meal of the day at 11 am.
Although his controversial regime draws astonishment and criticism alike, Johnson countered: “Sleep is the single most important thing any human does on any given day.”
Johnson said a no-sleep culture is embedded into many business circles, adding his friends often feel “trapped” by the pressure of a ‘grind’ lifestyle.
“If you look at it from a cultural identity standpoint [for] people who work hard at an entrepreneurial endeavor there’s this mythology that if you sleep under your desk, or you go days without sleep you’re a hero, that people will tell stories about you,” Johnson said.
“It’s almost like if you’re a great entrepreneur, and if you want to be respected by your peers, and if you want to achieve mythology-like status, you do that sleep deprivation thing.”
Johnson said when he speaks to peers about why they don’t get enough sleep, it’s often because the individual thinks they have to go through sleep deprivation in order to “be the kind of person they want to become.”
He added people “feel trapped that if they don’t [sleep less] they somehow won’t achieve ranking among the social group.”
Gates has echoed this thinking, saying on his podcast earlier this year: “In my thirties and forties when there would be a conversation about sleep it would be like ‘Oh, I only sleep six hours,’ and the other guy says ‘Oh, I only sleep five,’ then ‘Well, sometimes I don’t sleep at all.’
“I’d be like ‘Wow, those guys are so good, I have to try harder because sleep is laziness and unnecessary.”
Increased research into the benefits of sleep has begun to shift some of the ideology around deprivation.
As well as obvious health benefits such as a reduced risk of Alzheimer’s and other chronic diseases such as diabetes, heart disease, obesity, and depression, sleep is needed to operate well at work.
A 2010 study of more than 4,000 U.S. employees found fatigue-related losses total $1967 per employee, representing a “significant” drop in productivity.
Other studies have found a lack of sleep also compromises the quality of work.
In 2016 a report of the construction industry found that poor sleep led to a decrease in job competence, with good sleep helping predict the level of occupancy injury.
“The person who prioritizes sleep is going to be higher performing, they’ll be more lucid, they’ll have better ideas,” Johnson said. “The people who don’t sleep are literally half dead. They’re actually intoxicated, they’re impaired.”
Johnson was referring to a series of studies by the National Institute for Occupational Safety and Health (NIOSH) which found sleep deprivation results in similar impairments to alcohol intoxication.
The reports found being awake for 17 hours is the equivalent of having a blood alcohol content (BAC) of 0.05%, while being awake 24 hours is similar to having a BAC of 0.10%—a level at which it would be illegal for a person to drive a car.
“These are people who are leading organizations,” Johnson continued. “There are groups of people that are expecting them to make high-quality decisions on behalf of the entire group. It’s those very people who are not sleeping well and who are impaired in their judgment. It’s backward.”
Evidence supports Johnson’s point. A 2020 study of partially and totally sleep-deprived subjects found that a lack of sleep increased impulsivity and risk-taking in decision-making situations.
Additionally, well-rested participants gathered evidence to make well-informed decisions while their tired counterparts tended to be less litigious.
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Eleanor Pringle
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Newswise — SAN FRANCISCO — Sickle cell disease is a rare, inherited disorder in which the red blood cells become hard, sticky, and change shape, resembling the farm tool. People who have it can sometimes develop vision problems when these sickle-shaped cells get trapped in the small blood vessels as the back of the eye. Sickle retinopathy is an age-dependent process, with older people being at substantially higher risk, than younger patients. To learn more about how this condition manifests in children, researchers at the University of Tennessee Health Science Center conducted a large, retrospective review at their institution. What they found surprised them. One in three children had retinopathy, of which 9 percent required treatment, suggesting children need to be screened for vision problems as often as adults with sickle cell disease. The study will be presented today at AAO 2023, the 127th annual meeting of the American Academy of Ophthalmology.
“Our data underscores the need for patients — including pediatric patients– with sickle cell disease to get routine ophthalmic screenings along with appropriate systemic and ophthalmic treatment,” said lead researcher, Mary Ellen Hoehn, MD, professor of Ophthalmology at University of Tennessee Health Science Center.
Dr. Hoehn and colleagues also evaluated the effectiveness of different therapies for sickle cell disease. They found that hydroxyurea and chronic transfusions were associated with decreased rates of retinopathy, even when accounting for different genotypes.
To conduct the study, they evaluated records for 652 patients, aged 10 to 25 years (median age: 14) who underwent eye exams (2,240 visits) over a 12-year period. They found:
“We hope that people will use this information to better care for patients with sickle cell disease, and that more timely ophthalmic screen exams will be performed so that vision-threatening complications from this disease are prevented,” Dr. Hoehn said.
About the American Academy of Ophthalmology
The American Academy of Ophthalmology is the world’s largest association of eye physicians and surgeons. A global community of 32,000 medical doctors, we protect sight and empower lives by setting the standards for ophthalmic education and advocating for our patients and the public. We innovate and support research to advance our profession and to ensure the delivery of the highest-quality eye care. Our EyeSmart® program provides the public with the most trusted information about eye health. For more information, visit aao.org.
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American Academy of Ophthalmology (AAO)
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It’s uncomfortable to talk about older adults and driving, a fact that many families who’ve worried about a loved one’s dwindling eyesight, reaction time, or cognition behind the wheel are well aware of. The ability to drive isn’t a right, but in many parts of the U.S. it’s become a necessity, the only way to access the world outside the home. When an older adult’s freedom threatens their safety, who gets to make the choice to take a car or license away?
For a long time, the answer has been an unsure combination of the U.S. government, physicians, and family members. But as the population of Americans older than 65 grows at a faster rate than any other age bracket, seniors’ presence on the road is growing as well. According to the Federal Highway Administration (FHA), there were 48 million licensed drivers ages 65 and older in 2020, nearly 70% more than there were two decades before. Data from the FHA show that seniors account for 20% of drivers on U.S. roads, where the types of impairments frequently associated with aging incur a greater risk of crash involvement.
Policies meant to ensure drivers remain capable as they age—such as stricter vision-testing for license renewals and reporting requirements for dementia diagnoses—exist, but according to new research presented in late October at the 2023 Clinical Trials on Alzheimer’s Disease conference, they may be undermining—or at least complicating—their intended outcomes. For example, some states require that drivers (or their doctors) notify the Department of Motor Vehicles if they get diagnosed with certain conditions that are impossible to evaluate at DMV facilities, like diabetes, seizure disorders, and most importantly, dementia.
Dementia not only directly affects driving abilities, but it also reduces a person’s capacity to recognize their own impairments or dangerous behaviors. Concerned by this dual hazard especially among rising rates of dementia diagnoses, a team led by Hankyung Kate Jun, a research fellow at Harvard Medical School’s Department of Healthcare Policy, wanted to understand how dementia-reporting policies were impacting public health and driver safety. They found only one study ever published on the topic, which looked at dementia diagnoses among those hospitalized after crashes, and found no real trend in line with the policies. So, the team decided to compare expected and actual dementia diagnoses in each state using a predictive model—and found that physicians in the four states that require doctors to notify the DMV when they’ve diagnosed a patient were significantly more likely to underdiagnose dementia. In California, Oregon, Delaware, and Pennsylvania, the rate of underdiagnosis was 14%, compared to 9% in other states.
Fourteen other states require patients themselves to notify the DMV of their own diagnoses, but Jun’s team found no difference in diagnosis margins between these states and states with no mandate whatsoever. The researchers plan to next look at the number of reports actually made to each state’s DMV, licensing changes they’ve caused, and road-accident data—if they can get that information, they can potentially figure out if these unenforced self-reporting mandates are at all effective.
Read More: A Growing American Crisis: Who Will Care for the Baby Boomers?
Jun believes that the fear of losing the ability to drive may be stopping people from telling the DMV of dementia diagnoses. And in the four states with physician-reporting mandates, she adds, that fear could be discouraging people to seek medical help in the first place. “I do believe like the reason why doctors underdiagnose is not because the doctors want to underdiagnose, but because the patients are reluctant,” she says.
Though the study doesn’t reveal whether these policies are effective in preventing crashes and injuries, it does suggest that they may be part of the family and individual calculus determining whether older people developing dementia are getting the care they need—and highlights the difficult balance between ethical and safety concerns that state DMVs are tasked with establishing in an aging country.
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Haley Weiss
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The discovery of Arizona desert fish is making researchers rethink the history of the world!
In a surprising revelation, researchers at the University of Minnesota uncovered an unexpected treasure trove of longevity within the freshwater fishes of the Arizona desert. Their study, recently published in Scientific Reports, highlights three species within the Ictiobus genus, also known as buffalofishes, with lifespans exceeding 100 years.
This groundbreaking discovery not only shifts our understanding of vertebrate aging but also positions these desert dwellers as potentially key players in aging studies across disciplines.
The central figures of this study are the bigmouth buffalo, smallmouth buffalo, and black buffalo. Native to Minnesota, these species often fall victim to misidentification, mistakenly grouped with invasive species like carp. Consequently, inadequate fishing regulations fail to protect these potential longevity lighthouses. The collaborative research effort, led by Alec Lackmann, Ph.D., from the University of Minnesota Duluth, delved into the lifespans of these species and unraveled their potential in aging research.
Dr. Lackmann’s approach to determining the age of the buffalofishes diverges from traditional scale examination. The team extracted otoliths, or earstones, from the cranium of the fishes. Like the rings on a tree, these otoliths develop a new layer annually. Through meticulous thin-sectioning and examination under a compound microscope, researchers could count these layers, unlocking the true age of the fish.
The study’s results were nothing short of extraordinary:
Interestingly, these centenarian fishes were originally stocked into Roosevelt Lake, Arizona, in 1918. While their counterparts in Roosevelt Lake faced commercial fishing, the Apache Lake population thrived, undisturbed until recent angling activities.
The study also highlights a robust collaboration between conservation anglers and scientists, with anglers contributing to scientific outreach and learning. When anglers observed unique markings on the buffalofishes, they reached out to Dr. Lackmann, initiating a partnership that would lead to this study’s pivotal findings.
Looking ahead, Dr. Lackmann envisions a bright future for studying these unique fish. Their exceptional longevity offers a window into their DNA, physiological processes, and disease resistance across a wide age range. The genus Ictiobus could become a cornerstone in gerontological research, with Apache Lake potentially emerging as a scientific hub for diverse research endeavors.
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WTF
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Newswise — Up to 1.7 million people could be living with dementia in England and Wales by 2040 – over 40% more than previously forecast – finds a new UCL-led study.
Previous studies, based on data up to 2010, showed that dementia incidence had declined in high-income countries. However, the new research, published in The Lancet Public Health, indicates that dementia incidence started to increase in England and Wales after 2008.
Based on this estimated upward incidence trend, researchers project that the number of people with dementia in England and Wales may be significantly higher than expected in the future.
According to previous research* in England and Wales, the number of people living with dementia was previously predicted to increase by 57% from 0.77 million in 2016 to 1.2 million in 2040.
However, the new research, funded by the UK Economic and Social Research Council, suggests that this figure could be as high as 1.7 million.
Researchers examined nine waves of data from people over the age of 50 and living in private households in England between 2002 and 2019, from the English Longitudinal Study of Ageing (ELSA).
They found that the number of people with dementia decreased by 28.8% between 2002 and 2008. However, it increased again by 25.2% between 2008 and 2016.
A similar non-linear pattern was observed across subgroups according to age, sex, and educational attainment.
Most notably, researchers found that disparities in the rate of dementia incidence was increasing between education groups, as there was both a slower decline in 2002-2008 and a faster increase after 2008 in participants with lower educational attainment.
If the incidence rate increases as fast as what was observed between 2008 to 2016 (a 2.8% increase per year) researchers predict that the number of people with dementia in England and Wales is set to increase to 1.7 million by 2040 – approximately twice the number in 2023. This compares to an estimate of one million people if dementia rates had continued to decline as previously reported.
Lead author, Dr Yuntao Chen (UCL Institute of Epidemiology & Health Care), said: “It is shocking to think that the number of people living with dementia by 2040 may be up to 70% higher than if dementia incidence had continued to decline.
“Not only will this have a devastating effect on the lives of those involved but it will also put a considerably larger burden on health and social care than current forecasts predict.
“Continued monitoring of the incidence trend will be crucial in shaping social care policy.”
Although an increase in dementia cases has often been attributed to an ageing population, the researchers also found that the rate of dementia onset within older age groups is also increasing.
Principal investigator, Professor Eric Brunner (UCL Institute of Epidemiology & Health Care), said: “Our research has exposed that dementia is likely to be a more urgent policy problem than previously recognised – even if the current trend continues for just a few years.
“We have found that not only is the ageing population a major driver of the trend in England and Wales but also the number of people developing dementia within older age groups is increasing.
“We don’t know how long this pattern will continue but the UK needs to be prepared so we can ensure that everyone affected, whatever their financial circumstances, is able to access the help and support that they need.”
James White, Alzheimer’s Society’s Head of National Influencing, commented: “Dementia is the biggest health and social care issue of our time. Statistics from this Lancet Public Health study are a stark reminder that, without action, the individual and economic devastation caused by dementia shows no sign of stopping.
“We know that one in three people born in the UK today will develop this terminal condition in their lifetime. With prevalence on the rise, improving diagnosis has never been more important. Everyone living with dementia must have access to a timely, accurate and specific diagnosis, and who you are or where you live should have no bearing on this. The figures also make it clear that pressure on our already struggling social care system is only going to increase. Quality social care can make a huge difference to people’s lives, but we know that people with dementia – who are the biggest users of social care – are struggling with a care system that’s costly, difficult to access, and too often not tailored to their needs.”
Notes to Editors
* https://www.bmj.com/content/
For more information, please contact Chris Lane, UCL Media Relations. T: +44 (0)20 7679 9222 / +44 (0)7717 728 648, E: [email protected]
Yuntao Chen, Piotr Bandosz, George Stoye, Yuyang Liu, Yanjuan Wu, Sophia Lobanov-Rostovsky, Eric French, Mika Kivimaki, Gill Livingston, Jing Liao, Eric J Brunner, ‘Dementia incidence trend in England and Wales, 2002-19, and projection for dementia burden to 2040: analysis of data from the English Longitudinal Study of Ageing’, will be published in The Lancet Public Health on 26th October at 23:30 UK time and is under a strict embargo until this time.
The DOI for this paper will be: https://doi.org/10.1016/S2468-
About UCL – London’s Global University
UCL is a diverse global community of world-class academics, students, industry links, external partners, and alumni. Our powerful collective of individuals and institutions work together to explore new possibilities.
Since 1826, we have championed independent thought by attracting and nurturing the world’s best minds. Our community of more than 50,000 students from 150 countries and over 16,000 staff pursues academic excellence, breaks boundaries and makes a positive impact on real world problems.
The Times and Sunday Times University of the Year 2024, we are consistently ranked among the top 10 universities in the world and are one of only a handful of institutions rated as having the strongest academic reputation and the broadest research impact.
We have a progressive and integrated approach to our teaching and research – championing innovation, creativity and cross-disciplinary working. We teach our students how to think, not what to think, and see them as partners, collaborators and contributors.
For almost 200 years, we are proud to have opened higher education to students from a wide range of backgrounds and to change the way we create and share knowledge.
We were the first in England to welcome women to university education and that courageous attitude and disruptive spirit is still alive today. We are UCL.
www.ucl.ac.uk | Follow @uclnews on Twitter | Read news at www.ucl.ac.uk/news/ | Listen to UCL podcasts on SoundCloud | View images on Flickr | Find out what’s on at UCL Minds
About the Economic and Social Research Council
The Economic and Social Research Council (ESRC) is part of UK Research and Innovation (UKRI), a non-departmental public body funded by a grant-in-aid from the UK government. We fund world-leading research, data and postgraduate training in the economic, behavioural, social and data sciences to understand people and the world around us. Our work helps raise productivity, address climate change, improve public services and generate a prosperous, inclusive, healthy and secure society. www.ukri.org/esrc
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University College London
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Changes to the brain are natural as we age, which often makes it difficult to spot more aberrant signs of cognitive decline in older adults. Neurodegenerative diseases like Alzheimer’s and Parkinson’s, as well as other common disorders that can affect the mind, often first arise as clusters of symptoms that qualify as mild cognitive impairment, or MCI. In many cases, catching disease at this stage can massively increase the success of treatments—which is why researchers at the University of Southern California are so concerned by their recent analysis suggesting that over 90% of Americans with MCI remain undiagnosed. What’s more, of the more than 200,000 primary care physicians surveyed, all of whom see patients 65 and older, 99% are underdiagnosing MCI.
“We expected it to be bad, but we didn’t really expect it to be that bad,” says Soeren Mattke, director of the Brain Health Observatory at USC Dornsife’s Center for Economic and Social Research and a lead author on the team’s most recent paper. There’s a clear reason to address this oversight now. The first Alzheimer’s drug to be approved by the U.S. Food and Drug Administration, which became available this summer, can slow down the disease’s progress, but only if used in the early stages of the condition. About one-third of people diagnosed with MCI will develop dementia due to Alzheimer’s within five years. Mattke says that urgent need motivated the research, published Oct. 24 in the The Journal of Prevention of Alzheimer’s Disease. “We have to find these patients early and get them into treatment,” he says.
Read More: There’s Finally a Fully Approved Alzheimer’s Drug—But Getting It Won’t Be Easy
Getting an MCI diagnosis currently requires a lot of unlikely pieces to fall into place, explains Mattke. First, someone has to notice cognitive changes, which is difficult, given that MCI presents itself with inconsistent symptoms. In some people, it could manifest as unusual memory lapses, in others issues with orientation, and in others still as struggles with information processing or decision making. For physicians, this makes it hard to tell families and patients what to look out for, and for patients, it makes symptoms easier to hide. Neurological decline can be a major source of shame for older adults, who may go out of their way to compensate for symptoms in order to avoid detection by family members and clinical evaluation. This is even more true for people with MCI, whose mental changes fall outside the standard expected for their age group. Because MCI is, by definition, mild, it’s also unlikely to be noticed by someone who doesn’t know the patient well or doesn’t spend much time with them, including their primary care physician.
Good tests for MCI do exist, and if a patient arrives with concerns about mental impairment, a physician might administer the simplest one, which takes about 15 minutes to conduct and score. While 15 minutes might not seem like a lot, it’s just a few shy of the average 19 minutes that primary care physicians spend with their patients. A test is a great option if it’s what a patient came in for, says Mattke, but it’s impossible for the large number of patients who come in for a check-up or other concern and only mention a family member’s worries about their cognition offhandedly at the end of a visit—a common experience for doctors treating older populations. “Then of course, that’s tough for the primary care doctor, because if you start that conversation that takes about half an hour and that upsets your entire day,” he says.
Shorter tests, or tests that can be administered in the waiting room, are clear goals for experts. “These tests are all very new,” says Mattke.
Mattke says he hopes to do additional research that would allow him to put together risk-scoring algorithms that physicians could use to identify people for testing, similar to those that exist to spot older adults at risk for cardiac events. This would be particularly beneficial for improving detection in socioeconomically disadvantaged groups, where risk factors like poor blood pressure and cholesterol—both associated with dementia as well as cardiovascular events—are higher.
“Brain cells don’t grow back,” says Mattke. If you feel like you or a loved one might be showing signs of MCI, “don’t let a physician brush it off.”
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Haley Weiss
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Vera Wang just revealed that her youthful glow doesn’t have anything to do with maintaining a clean diet.
The famed fashion designer, 74, talked about her fast-food habits and her aging philosophy with Page Six at Thursday’s DKMS gala in New York, an annual event run by the Deutsche Knochenmarkspenderdatei nonprofit.
Revealing how she’s not one to keep to a restricted meal plan, Wang admitted to sometimes eating fast food for days on end.
“I do eat McDonald’s, absolutely,” said the bridalwear visionary, who has previously been photographed with a burger and french fries from the chain. “I order it every day, like two weeks on it, and then I’ll change.”
She’s not averse to sweet things either, telling Page Six about some of her go-to Dunkin’ orders.
“I like the cream-filled, sugar-coated donut,” she said. “I like the pink with sprinkles, too.”
While eating lean doesn’t seem to factor into Wang’s wellness plan, she actually credits her high-stakes fashion career with maintaining her ageless appearance.
“Work keeps you young and stimulated,” she told Page Six, adding that her hectic schedule has also included raising two daughters. “Keeping busy is the best antidote [for] good health.”
The designer has dressed some of the most famous brides of all time, working on wedding looks for celebs like Victoria Beckham, Gwen Stefani, Hailey Bieber and Ariana Grande.
Wang previously attributed her clock-stopping looks to not only her job, but the occasional cocktail.
Back in 2020, she told an Instagram follower that her self-care routine included “work, sleep, a vodka cocktail, [and] not much sun.”
The fashion legend is also the proprietor of the adult beverage brand Vera Wang Party, which sells both a classic prosecco and bubbly rosé.
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BYLINE: Noah Fromson
Newswise — Older adults who live in disadvantaged communities are less likely to attend cardiac rehabilitation after common heart procedures, a Michigan Medicine-led study finds.
The study aimed to calculate how many Medicare beneficiaries attended cardiac rehabilitation, a medically supervised program exercise and education program, after coronary revascularization between mid-2016 and 2018.
Patient communities were categorized using the Distressed Community Index, which analyzes economic well-being and social determinants of health, such as educational disparities and poverty rate, of United States zip codes.
Only 26% of patients from distressed communities use cardiac rehab, compared to 46% of patients from areas deemed prosperous. Any patient who attended cardiac rehab, no matter where they lived, had a reduced risk of death, hospitalization and heart attack, according to results published in Circulation: Cardiovascular Quality and Outcomes.
“Addressing barriers to participation in cardiac rehabilitation in distressed communities may improve outcomes for these patients and reduce longstanding disparities in such outcomes,” said first author Michael P. Thompson, Ph.D., assistant professor of cardiac surgery at University of Michigan Medical School.
“While some individuals who face geographic barriers to participation may benefit from transportation services or virtual options for cardiac rehab, there is a critical need to address socioeconomic barriers that prevent so many patients from attending this lifesaving therapy.”
Additional authors include, Hechuan Hou, Francis D. Pagani, M.D., Ph.D., Robert B. Hawkins, M.D., Devraj Sukul, M.D., and Donald S. Likosky, Ph.D., all of University of Michigan, James W. Stewart II, M.D., of Yale School of Medicine, and Steven J. Keteyian, Ph.D., of Henry Ford Health.
This study was funded as part of a career development award Thompson received from the Agency for Healthcare Research and Quality (AHRQ, Grant no. 1K01HS027830).
Paper cited: “Relationship Between Community-Level Distress and Cardiac Rehabilitation Participation, Facility Access, and Clinical Outcomes After Inpatient Coronary Revascularization,” Circulation: Cardiovascular Quality and Outcomes. DOI: 10.1161/CIRCOUTCOMES.123.010148
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Newswise — Toronto, ON — New research from the University of Toronto has revealed the mental health toll of the COVID-19 pandemic on older adults with peptic ulcer disease (PUD), a painful condition in which gastric sores develop in the lining of the stomach or upper portion of the small intestine.
The researchers examined a subsample of older adults from the Canadian Longitudinal Study on Aging, a national dataset of older Canadians. The sample consisted of 1,140 older adults with PUD, of whom 689 had a pre-pandemic history of depression and 451 had no history of depression. By using longitudinal data, the researchers were able to compare the mental health trajectories of those with and without a history of depression. The article was published this week in PLOS ONE.
Among older adults with PUD and no lifetime history of depression, approximately 1 in 8 (13.0%) developed depression for the first time during the COVID-19 pandemic. These numbers were substantially higher when compared to depression levels before the pandemic (2015-2018).
“Although individuals with peptic ulcers were already known to be vulnerable to depression, our findings show that the pandemic severely exacerbated this vulnerability,” said lead author Esme Fuller-Thomson, Professor at the University of Toronto’s Factor-Inwentash Faculty of Social Work (FIFSW) and director of the Institute for Life Course & Aging (ILCA). “COVID-19 introduced many unforeseen stressors for people with chronic health conditions, such as higher levels of stress and lower levels of physical activity and social support, which may contribute to their worsening mental health.”
When the analysis was limited to those who had a lifetime history of depression, approximately 1 in 2 (46.6%) experienced recurrent or persistent depression during the pandemic.
“One of the major risk factors for depression in later life is having a previous history of depressive episodes,” said co-author Hannah Dolhai, a former research assistant at the ILCA. “Older adults with a history of depression who also had to navigate challenges with managing their chronic illness during the pandemic are a vulnerable subpopulation of Canadians.”
The researchers also identified several risk factors for depression among those with PUD, such as experiencing difficulty accessing healthcare.
“We found that individuals who reported challenges with healthcare access during the pandemic had a higher risk for depression. It’s important to think about the potential cascading mental health consequences of the healthcare restrictions that occurred during COVID-19,” said co-author Andie MacNeil, a research assistant at the FIFSW and Institute for Life Course and Aging. “While the shift towards telemedicine helped maintain healthcare continuity for many individuals, it is not always accessible or preferable for some patients”
Other risk factors for depression among older adults with PUD included feeling lonely at the beginning of the pandemic and experiencing functional limitations.
“Loneliness is a well-established risk factor for depression. For many older adults, the physical distancing limitations early in the pandemic meant increased time alone and declines in social support. Although these guidelines were important to protect the health of Canadians, they can also had unintended mental health consequences. It is important to find ways to foster social connection even when staying apart,” said co-author Grace Li, PhD candidate in the Sociology Department at the University of Victoria.
Co-author Ying Jiang, Senior Epidemiologist at the Public Health Agency of Canada points out that previous research on the relationship between PUD and depression has highlighted how symptoms like chronic pain can severely disrupt functional status and dramatically reduce quality of life in patients. “It is unsurprising that this relationship persisted into the pandemic, and that those with reduced functional status faced a higher risk of depression,” Jiang said.
Women were also found to have a higher risk of depression when compared to men.
“During the pandemic, many women experienced increased household labour and caregiving responsibilities due to school closures and restrictions in other community services, like older adult day programs. This exacerbation of gender-role stress may have impacted the mental health of many women,” said co-author Margaret de Groh, Scientific Manager at the Public Health Agency of Canada.
“By drawing attention to those with the highest risk for depression, we hope our findings will help inform targeted screening and intervention. Many older adults may still need mental health support in the post-COVID era,” said Fuller-Thomson.
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Newswise — Fifty years ago, in the fall of 1973, a landmark study began in the rural Louisiana town of Bogalusa that would change how the world sees heart disease.
The Bogalusa Heart Study, which tracked the health of the town’s children into adulthood, found for the first time that heart disease begins in childhood.
The community-wide study pioneered a new approach to pediatrics by proving that high blood pressure and high cholesterol in children doesn’t fade with age, with no intervention, and could result in hypertension and heart disease later in life. One of the longest-running biracial health studies in the world, it was also one of the first to identify race-based health disparities between Black and White participants.
“This study had a global impact on healthcare and left a tremendous public health legacy,” said Lydia Bazzano, principal investigator of the Bogalusa Heart Study and director of the Center for Lifespan Epidemiology Research at Tulane University School of Public Health and Tropical Medicine. “There’s never going to be a clinical trial that proves that childhood intervention results in improvements 40-50 years later. This is the best evidence we have, and I don’t know if there will ever be another study like this.”
This fall, Tulane University is celebrating 50 years of groundbreaking research by the Bogalusa Heart Study, while also looking ahead to what the study’s next 50 years can achieve.
The Bogalusa Heart Study – in collaboration with researchers from LSU’s Pennington Biomedical Research Center and Mary Bird Perkins Cancer Center – received a $14.5 million grant from the National Institute on Aging in 2019 to investigate whether high blood sugar levels in early life can later lead to declines in brain health.
With a now middle-aged cohort of participants, Bazzano said she believes Bogalusa “can do the same thing for brain health in the next 50 years that we did for heart health in the last 50.”
“It all starts with the heart,” Bazzano said. “The brain is one of the first stops for blood that comes from the heart, so it made sense to look at how vascular aging impacts the brain.”
Early results indicate that participants who perform worse on neuropsychological testing previously showed more heart disease risk factors. Brain scans of middle-aged participants also revealed white brain lesions on those who, as young adults, had slightly elevated blood sugar levels. These lesions, called white matter hyperintensities, indicate not enough oxygen and nutrients are reaching the smallest blood vessels in the brain and are associated with cognitive decline.
Researchers are also working to identify blood biomarkers of dementia in the hopes of one day being able to identify risk of dementia via a blood test.
“Just as childhood was not thought of as a time when heart disease would start, early middle age is not seen as time when dementia might originate,” Bazzano said. “This could have a revolutionary effect on the field.”
The Bogalusa Heart Study has included more than 16,000 participants since it was started by pediatric cardiologist and Tulane University graduate Dr. Gerald Berenson. The data collected continues to be vital to research around nutrition, childhood obesity and genetic risk factors.
While the longevity of the Bogalusa Heart Study can be partly attributed to the dedication of its researchers, the study’s historic streak may have ended long ago without its deep roots in the community.
Joe Culpepper, a native and former police chief of Bogalusa, was 11 years old when he and 5,000 children first began receiving health screenings in 1973. A long white trailer of lab equipment pulled up to his elementary school. Researchers organized students into groups with bracelets of colored yarn. Blood pressure was checked. Weight was measured. Blood was drawn.
The check-ups continued as years went on, but Culpepper had no idea that the findings of the study would have global implications.
“I still go to get tests done. One of my brothers is still actively participating. Friends in Baton Rouge occasionally come back to Bogalusa to participate, and my sister-in-law now manages the lab,” Culpepper said. “We’re all proud of the study, and the medical knowledge gained from studying folks like me our whole lives hopefully makes things better for the kids coming up.”
At the Bogalusa Heart Study lab, two current employees are former participants in the study. Another, Phylis Cothern, has been a lab technician for 10 years, but before her, her mother began working for the study in 1972, when the pilot was underway. Now, Cothern’s two daughters and her granddaughter are study participants.
“We depend on the community and the community depends on us. It’s overwhelming the amount of good this study has done for the community, but I’m just honored to be a part of the legacy,” Cothern said.
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According to a recently published article on Axios, women have higher out-of-pocket expenses for their health care than men despite having similar health insurance. Even when removing maternity care from the equation, women each year are paying $15.4 billion more out of pocket for health care. This so-called ‘Pink tax’ reflects the penalty levied on females for everything from tampons and razors—is alive and well in the U.S. healthcare system. Below are some of the latest headlines in the Women’s Health channel on Newswise.
A New AI Model Has Been Developed to Improve Accuracy of Breast Cancer Tumor Removal
-University of North Carolina School of Medicine
Social media and low self-compassion behind rise in cosmetic surgery
-University of South Australia
Exposure to extreme heat associated with adverse health outcomes for pregnant women
-University of California, Irvine
Iron supplements provided in prenatal visits improved outcomes
-UT Southwestern Medical Center
Study finds the placenta holds answers to many unexplained pregnancy losses
-Yale University
Witchcraft accusations an ‘occupational hazard’ for female workers in early modern England
-University of Cambridge
Substance Abuse in Pregnancy Doubles Cardiovascular Risk
-Cedars-Sinai
In major breakthrough, researchers close in on preeclampsia cure
-University of Western Ontario (now Western University)
When it comes to starting a family, timing is everything
-University of Oxford
Using personalized medicine to target gynecological cancers
-University of California, Los Angeles (UCLA), Health Sciences
Internet searches increased for self-managed abortions when Roe vs. Wade was overturned
-University of California, Irvine
Stem cell-derived components may treat underlying causes of PCOS
-University of Chicago Medical Center
High levels of particulate air pollution associated with increased breast cancer incidence
-National Institute of Environmental Health Sciences (NIEHS)
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Newswise — WASHINGTON—A newly published quality improvement study shows how a simple intervention by health care providers reduced the number of older adult patients with type 2 diabetes at risk for hypoglycemia (low blood sugar) by almost 50% and led to de-escalation of diabetes medications that cause hypoglycemia in 20% of patients.
Twenty percent of Americans aged 65 and older have diabetes. This age group is particularly at risk for hypoglycemia because older people are often overtreated with insulin and other diabetes medications that can cause hypoglycemia. Severe hypoglycemia episodes in older adults can lead to adverse events such as falls, seizures, coma, and even death.
Severe hypoglycemia from insulin and certain oral type 2 diabetes medications is the second most common adverse drug event resulting in emergency room visits and hospitalizations in older people with diabetes.
“This study demonstrates that a low-cost clinical decision support tool, without the additional use of continuous glucose monitoring technology, can decrease the number of patients at high risk for hypoglycemia and reduce overtreatment with insulin and diabetes medications that cause hypoglycemia,” said study author Jeffrey B. Boord M.D., M.P.H., of Parkview Health System in Fort Wayne, Ind. Boord is the Chair of the Endocrine Society’s Hypoglycemia Prevention Initiative Steering Committee. “The patients in our study also reported significant reductions in the negative impact of hypoglycemia on their daily lives.”
The study included 94 patients at risk of treatment-related hypoglycemia at Pottstown Medical Specialists in Pottstown, Pa. Physicians were trained on how to use a clinical decision support (CDS) tool to facilitate shared decision making with patients and improve health outcomes.
During three clinic visits over 6 months, the clinicians used the tool to assess hypoglycemic risk, set individualized HbA1c (blood sugar level) goals, and reduce or discontinue the use of diabetes medications that can cause hypoglycemia.
The use of the clinical decision support tool and shared decision making reduced the at-risk population by 46% and led to the discontinuation of hypoglycemic medications in 20% of participants. Patients also completed a validated patient-reported outcome tool (TRIM-HYPO) to evaluate the impact of non-severe hypoglycemic events on their daily lives. The patients reported improvements in their daily functioning, emotional well-being, diabetes management, sleep disruption and work productivity related to reduction in non-severe hypoglycemic events.
“Because this intervention was so successful, we hope that our clinical decision support tool could be adopted for use in other primary care settings to lower the risk of hypoglycemia and improve the overall well-being of older adults with diabetes,” Boord said.
The HypoPrevent study was part of a larger, multi-year joint effort by the Endocrine Society and Avalere Health, known as the Hypoglycemia Prevention Initiative, to determine best practices in primary care to reduce the impact of hypoglycemia on older (65+) people with type 2 diabetes who use medications that cause hypoglycemia and have a recent A1c <7%, both of which put them at increased risk of hypoglycemia.
In conjunction with HypoPrevent, the Society formed a technical expert panel to develop quality measures—tools that help us measure or quantify healthcare processes, outcomes, patient perceptions and organizational structure—to reduce the risk of hypoglycemia in the outpatient setting. These performance measures are designed to help providers identify opportunities to improve patient care.
For details about the initiative including an implementation guide for how to use the clinical decision tool and resources on the key role of the diabetes educator, visit: endocrine.org/hypoglycemia-prevention-initiative.
The other authors of this study are Deborah A. Koehn of VCU Stony Point Women’s Health in Richmond, Va.; Kathleen Marie Dungan of The Ohio State University in Columbus, Ohio; Amisha Wallia of Northwestern University Feinberg School of Medicine in Chicago, Ill.; Deborah Otcasek Lucas of Avalere Health and BridgingCare LLC in Washington, D.C.; Robert W. Lash and Mila N. Becker of the Endocrine Society in Washington, D.C.; and Lawrence D. Dardick of David Geffen School of Medicine at UCLA in Los Angeles, Calif.
The study was funded by Abbott Laboratories, Eli Lilly and Company, Merck, Novo Nordisk and Sanofi.
The study, “Reducing Hypoglycemia From Overtreatment of Type 2 Diabetes in Older Adults: The HypoPrevent Study,” was published in the Journal of the American Geriatrics Society.
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Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world’s oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.
The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at www.endocrine.org. Follow us on Twitter at @TheEndoSociety and @EndoMedia.
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Newswise — مدينة روتشستر، ولاية مينيسوتا — البلعميات هي إحدى أنواع خلايا الدم البيضاء، وهي جزء من خط الدفاع الأول للجسم ضد العدوى. بالإضافة إلى دورها في قتل الكائنات الدقيقة الضارة، يمكن للبلعميات بدء استجابة الجسم ضد الأورام. على الرغم من ذلك، فالبلعميات -مثل كل الخلايا الأخرى- تتقدم في العمر، وربما تدخل في مرحلة الشيخوخة. قد يرتبط هذا بتقدم عمر الإنسان، أو إصابته بالأمراض، أو بمختلف المشكلات الفسيولوجية.
عندما تصبح البلعميات خلايا مسنة، تتوقف عن التكاثر، إلا أنها لا تموت، ولا يتم التخلص منها دائمًا. لذا تتراكم البلعميات المسنة في بعض الأنسجة وتفرز بعض الجزيئات الضارة. لهذا يطلق على الخلايا المسنة اسم “خلايا الزومبي”. وحتى الآن، لم نستطع التوصل إلى سبب تحول الخلايا السليمة إلى خلايا مسنة.
في هذا البحث الجديد والذي نُشر في مجلة Cancer Cell البحثية، اكتشف الباحثون أن الخلايا البلعمية المسنة لا تتراكم فقط في الرئة، بل وتعزز من نمو ورم الرئة.
وضح د. دارِن بيكر أن “البيولوجي المتخصص في الخلايا المسنة في Mayo Clinic وكبير المؤلفين” من الناحية النظرية، لم نتوقع وجود احتمالية لأن تتحول البلعميات لخلايا مسنة تتسبب في نمو الورم. “لذا يقربنا هذا البحث خطوة من فهم كيفية تكون الأورام على المستوى الخلوي.”
اكتشف د. بيكر وزملاؤه أن البلعميات المسنة قد تمنع الجهاز المناعي من الاستجابة لمنع النمو الشاذ للخلايا. وبالتالي يؤدي هذا لتكون ورم.
“ووضح د. لويس بريتو، الباحث الرئيسي، وزميل أبحاث ما بعد الدكتوراه، وخريج كلية Mayo Clinic للدراسات العليا للعلوم الطبية الحيوية. “استطعنا من خلال التجارب والتحليلات المختلفة أن نفرّق بين البلعميات المسنة وغيرها من البلعميات الطبيعية. ووجدنا أنه إنه استطعنا التخلص من البلعميات المسنة بأساليب جينية أو دوائية، فيمكننا تأخير عملية تكوٌن الورم.
استنتج الباحثون أن الخلايا محتملة التسرطن تتواصل مع الخلايا المحيطة بها بما في ذلك البلعميات. وتحفز الخلايا محتملة التسرطن البلعميات لتتحول لخلايا مسنة. بعدها، تساهم الخلايا المسنة في تغيير المنطقة المحيطة لتعزيز نمو الورم.
في البداية اعتقد الباحثون أن التخلص من الخلايا المسنة سيؤدي إلى زيادة الأورام الغُدّية في الرئة، وهو نوع الورم الذي كانوا يدرسونه. ولكن أظهرت نتائج التجارب الأولية خلاف ذلك.
وضح د. بريتو “كان الأمر محفِّزًا، فكلما قمنا بتجربة كانت النتائج عكس توقعنا تمامًا.” “إن أزلنا مثبطات الأورام المسنة فمن المتوقع أن تزيد نسبة الأورام. ولكن النتائج أظهرت العكس. فبعد إزالة مثبطات الأورام المسنة، قلت نسبة الأورام.”
عمل الباحثون مع المؤلف المشارك د. هو لي، الباحث في الطب الفردي في Mayo Clinic، وأجروا تسلسل الحمض الننوي الريبوزي أحادي الخلية في معمله. ساهم هذا البحث في تحديد البلعميات الرئوية كخلية رئيسية تعزز نمو الأورام. والآن، يعتقد الباحثون أن البلعميات تستجيب لإشارات الخلايا محتملة التسرطن مع بدء تكون الورم.
يقول د. بيكر “أعدنا التفكير في فرضياتنا الأولية، فقد تعملنا الكثير عما يمكن أن تفعله الخلايا. بعدها اتضح لنا كيف يمكن للبلعميات المسنة أن تؤثر على الخلايا الأخرى وعلى البيئة وعلى جهاز المناعة.”
دُعم هذا البحث من قبل مركز بول ف. جلين لعلم أبحاث الشيخوخة البيولوجي التابع لـ Mayo Clinic وكلية Mayo Clinic للدراسات العليا للعلوم الطبية الحيوية.
تم نشر ورقة بحثية تكميلية في مجلة Cancer Cell من قبل الباحثين في المملكة المتحدة.
للحصول على القائمة الكاملة للمؤلفين والإفصاحات والتمويل، راجع الورقة البحثية.
لمزيد من المعلومات، يرجى زيارة ديسكافريز إيدج.
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نبذة عن مايو كلينك
مايو كلينك هي مؤسسة غير ربحية تلتزم بالابتكار في الممارسات السريرية والتعليم والبحث وتوفير التعاطف والخبرة لكل مَن يحتاج إلى الاستشفاء والرد على استفساراته. لمعرفة المزيد من أخبار مايو كلينك، تفضَّل بزيارة شبكة مايو كلينك الإخبارية.
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While it’s not exactly accurate to say it was a voice from the grave that commanded me to drop out of the Mrs. America pageant, it’s not exactly a lie, either. The truth lies somewhere in between and involves a questionable photographer, a threat from a friend to disown me, and a dingy bra once worn by Ivana Trump. But for five days, I was Cathy Alter, your Mrs. Georgetown DC.
It started from a place of insecurity — never a good thing in competition. My 11-year-old son, Leo, and I were sharing a late lunch at a British-style pub in Washington’s Dupont Circle. As we sat demolishing our mozzarella sticks, I took a moment to check my phone for emails. Maybe it was my text neck, or maybe Leo had never seen me in severe profile, but whatever the case, he reached over and grabbed the hunk of loose flesh residing below my chin (a wattle, a friend would helpfully explain).
“What’s that?” he asked, tugging on it like an udder.
I don’t remember how I answered him. But I do remember trying not to cry or ask my son if he was some kind of sociopath.
“I feel bad about my neck,” Nora Ephron confessed, in the opening essay and 2006 book of the same name.
“Our faces are lies and our necks tell the truth,” she wrote. “You have to cut open a redwood tree to see how old it is, but you wouldn’t have to if it had a neck.”
These days, at 57, it’s hard not to look in the mirror without thinking about how my reflection has changed. It’s me but not me. The face is certainly mine, just more gutted, the area underneath my eyes carved out by a wood gauge. It’s less feminine, somehow, and more Founding Fathers, especially when my hair is pulled back in a Jefferson braid. We won’t discuss my burgeoning FUPA.
To accept this image would be the healthiest way to proceed. The most empowering thing I could do for myself would be to love the marionette mouth, the nasolabial folds, the “elevens” between my brows, the time stamps that make this face uniquely mine. To say, to sing, to emblazon on a T-shirt: Here I am, world! A middle-aged woman with declining looks and a soft body!
Instead, I went home and sobbed to my husband, Karl.
“All boys should think their mothers are the most beautiful women in the world,” I said through my tears. “And it’s clear that Leo does not.”
“Well,” Karl said, “what can you do about it?”
I couldn’t tell if he was answering me rhetorically or expecting me to come up with an action plan.
And I did have a plan. Or, more accurately, a wild impulse that stomped on any attempt at levelheadedness.
“I’ll tell you what I’m going to do,” I told him. “I’m going to enter a beauty pageant — and win.”
When I was growing up in Connecticut, my parents threw an annual Miss America party where guests bet on the contestants as if the young women were racehorses. It was the hottest ticket in town. Friends arrived in evening gowns and tuxedos, tossed $20 into the pot, and rooted for their “girl” while tearing down the 49 others.
My mother, a 6-foot-tall beauty with a penchant for red lips and backless suede dresses, could be especially vicious, taking note of a competitor’s “thunder thigh” or “unfortunate underbite” or describing a pair of straight-on nostrils as looking like “the Holland Tunnel.”
As the owner of the hippest clothing boutique the Bermuda-bag-carrying women of our sleepy town had ever seen, my mother was a true arbiter of style and presentation. By midnight, everyone was tanked and the guest who got closest to choosing the evening’s winner paraded around in a homemade sash and dime-store crown, both courtesy of my mother.
Now, decades later, I found a slew of pageants on Pageant Planet, a website that consolidates local and regional contests including Miss Earth USA, Mr. Crimson and Cream, and the pageant I wound up entering, Mrs. DC America. There were pageants for veterans, for senior citizens (I’m still a few years away from that one), for full-figured women, and one that sounds like a meta version of itself, The Empowered Woman pageant. If I were to create a montage of the contestants I saw across the site, the result would look like the b-rolls from all the Real Housewives franchises in existence.
The rules to enter the Mrs. DC America pageant were straightforward. If you were married, you could enter — which meant I could potentially be competing with child brides. Contestants are judged in three categories: the interview, the evening gown and the swimsuit. As if striding across the stage in a bathing suit and high heels wasn’t terrifying enough, there would be an opening dance number. With choreography. The winner of Mrs. DC would go on to represent the District of Columbia at the national Mrs. America Pageant in Las Vegas.
The next morning, I called one of the pageant directors. After a bit of chitchat, I learned that I had a little less than five weeks to prepare for the event, which would be held at a community center over an hour away, in Frederick, Maryland. Somehow, I’d imagined that I’d have at least a year to get ready, both physically and mentally. Now things were becoming both very real and very surreal.
“What do you want your sash to say?” she asked.
When I hesitated, baffled by her question, she clarified. “Where do you live in Washington?”
Which is how I appointed myself Mrs. Georgetown DC, after forking over a deposit of $250 (the entire cost of entry was $750) and promising to schedule a headshot with the official pageant photographer within the week.

I immediately launched into overdrive, making a to-do list like I was planning my wedding. Each action item begot new actions. I made an appointment for highlights, but did I also want to talk about hair extensions? How much were hair halos? (What were hair halos?!) There was no time to sit and reflect on who I was fast becoming.
I called the photographer and asked him what I’d need to bring to the photo shoot. Everything on his list included the word glitzy. Also, he advised, “Wear something that either shows your cleavage or your shoulders but not both. That’s just overkill.”
He suggested I buy a bag of rhinestones and glue them onto my bathing suit, which, for some reason, he kept calling a “one-piece bikini.”
“Are you going to photograph me in a bathing suit?” I asked him.
“No,” he said. “I just wanted to tell you about rhinestones.” His parting advice, worthy of its own bedazzled T-shirt was, “Go glam or go home.”
My friends were divided on my new title. Some had a field day at my expense. “Can your bathing suit be Victorian or come with a turtleneck?” asked one. “Does AARP have a beauty pageant?” asked another, choking back laughter. One emailed me an Amazon link for Preparation H, which has famously been used to tighten bags under the eyes. “Maybe you can use this on your butt, too,” was the subject line.
Others were more perplexed.
“It’s ironic that you’re looking for acceptance and confidence in the very place designed not to give it,” said one of my closest friends, expressing concern.
A few were outraged. When I met a friend and former editor, she pounded on the table. “You can’t do this!” she said, holding her fist up for another strike. “What does this say about the progress we’ve been making as women?”
She brought up how precarious it is to be female in the wake of Roe v. Wade and the gutting of abortion rights and the horrible message about appearance that I would be sending to Leo. She told me she wasn’t sure if she could be my friend if I went through with the pageant.
Still another saw me as a champion just for entering: “You’ve been given a bigger stage, to stand up for all people who feel less than. You’re saying, ‘I’m here, I made it, and so can you.’”
I had been Mrs. Georgetown for two days before the idea of competing began to seem like a genuinely half-baked idea. What the heck was I doing? And what sort of message was I sending to myself? To my husband? To Leo? (“Do you think I could win?” I had asked the poor kid, who immediately looked to Karl for a clue before answering, “It depends on the competition.”)

I’ve always had a complicated relationship with beauty. As their ruthless Miss America parties suggest, my parents placed great value on physical appearance. When we were little, my father used to chase my younger brother and me around our swimming pool with a spray bottle of Sun In hair lightener. After growing up poor, eating mayonnaise sandwiches and fending for himself, having golden-haired, sun-kissed children who looked like they belonged in the Kennedy compound was, for him, an emblem of success.
My mother’s guiding principle was that it was more important to look good than to feel good. When I was in high school, she sat me down and gently explained that because I was no natural beauty — “no Christie Brinkley” were her words — I’d always have to wear makeup.
I was on the tender cusp of womanhood, and my mother’s grim appraisal took root in my soul. Before dementia completely robbed her of the ability to speak, the last clear words my mother said to me were, “How about some blush?”
On my third day as Mrs. Georgetown, I decided it was time to try on evening gowns at my favorite consignment shop in D.C. Even though the saleswomen aren’t permitted to mention the origin stories of their merchandise, I’ve gotten in pretty good with some of the staff and have been able to wheedle out some details.
Along these lines, I wound up in the dressing room with what I knew was an evening gown once worn by Ivana Trump by a designer whose name I didn’t recognize. It was $125 and the color of tomato sauce from a can, with a mermaid silhouette, red jewels scattered down the front, and about 40 miles of tulle. When I unzipped it, I saw there was a grimy Calvin Klein strapless bra sewn inside, size 36C, and I had a sudden pang, knowing such a private detail about Ivana. My mother, too, wore a 36C. Placing my own breasts inside the bra — and being this close to its original owner — was surprisingly intimate.
I looked at myself in the dressing room mirror, trying and failing to imagine myself striding across a stage in a conference center in Frederick, Maryland, giving a royal wave, chest out, smile aided by Vaseline on my teeth, hammertoes screaming at the straps of my stilettos.
“Take it off,” it said. “It’s not you,” it said.
Whether it was my mother speaking or Ivana, it didn’t matter. The dress wasn’t me. And neither, I realized, was the pageant.
My mother often warned me about falling for a pretty face. “Looks fade,” she had said after a man with movie star looks obliterated my heart. She could have been talking about her own vulnerabilities around appearance and aging. It was the way I knew that, despite her critical eye, even she recognized deep down that there were things more valuable than looks. My mother would have been unsparing in her assessment of my chances in the pageant (none) and in my decision to enter it (dumb).

What good is beauty, anyway? It was surely a burden for my mother, who tried mightily to keep up appearances until that weight shifted to my father. He became her de facto makeup artist as she sat strapped in a wheelchair, unable to perform her own ministries, her hands clenched in rage.
After watching him spoon-feed her lunch (“Now, now,” he’d say whenever she tried to bite his fingers), the sight of him dabbing her lips with her trademark Love That Red made me reevaluate my own definition of devotion — of obligation. In the face of the inevitable, my father’s tacit efforts broke my heart.
On my final day as Mrs. Georgetown, I phoned the pageant director and dropped out of the race.
“Did something happen?” She sounded aghast, like maybe I had microderm-ed my face off.
“I don’t have the full support of my family and friends,” was my excuse, which approached the truth, at least partially.
The woman who went on to wear my Mrs. Georgetown sash, I learned later, was from Rockville, Maryland. In her official pageant headshot, she looks a little like a Facetuned Jennifer Coolidge.
The pageant fell on the same weekend as my father’s 90th birthday. Home in Connecticut, I showed my father a photo of my “replacement.”
“Good thing you dropped out,” he said. “You didn’t stand a chance.”
“Grandpa!” Leo looked at my face, concerned.
“Thanks for your vote of confidence,” I said, lightly punching his arm and reassuring myself that limitations are not heritable.
Later that night, Leo slipped me a note before bedtime. It read, in part, “I love you for yourself. I love your sweet, sweet, heart. Though you are beautiful, it’s what is inside that counts.”
It is a note I wish my mother would have written and dropped in the mail, addressed to herself.
Cathy Alter’s articles and essays have appeared in O, the Oprah Magazine, The Cut, Wired, and The Washington Post, among others. She is the author of “Virgin Territory: Stories From the Road to Womanhood,” the memoir “Up for Renewal: What Magazines Taught Me About Love, Sex, and Starting Over,” and “CRUSH: Writers Reflect on Love, Longing, and the Lasting Power of Their First Celebrity Crush.” She lives in Washington, D.C.
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BYLINE: Kelly Craine
Newswise — National Daughters Day is Sept. 25, an oft-overlooked holiday that has been around since 1932. But much like the holiday, adult daughters are often unnoticed for the important role they play in the lives of their parents.
Allison M. Alford, Ph.D., clinical associate professor of business communication at Baylor University and co-host of the weekly podcast, “Hello Mother, Hello Daughter,” researches adult daughters and their “invisible labor” in maintaining the unity of a family. Adult daughters find themselves providing support, nurturing and much more in a socially and communicatively constructed, shaped and molded role that includes navigating, responding to and negotiating cultural and familial discourses. These behaviors occur throughout a daughter’s life and represent significant resources funneled toward her parents to maintain and nurture a relationship.
Alford’s research on “daughtering” – the active way that daughters relate to and care for parents – is how she describes the work and effort that daughters provide their parents.
“It’s that purposeful work that helps relationships flourish but often goes uncredited as work, even by daughters themselves, in part because the efforts are wrapped in misleading language and society hasn’t adopted a lexicon specifically for daughtering,” said Alford, who edited the book, “Constructing Motherhood and Daughterhood Across the Lifespan,” with research partner Michelle Miller-Day, Ph.D., of Chapman University in Orange County, California.
Daughtering involves such “invisible labor” as planning and organizing family events, resolving conflicts, acting as a buffer with other family members, preparing for the future and more—with the intent of supporting important family relationships, Alford said. With dashes of “mental load” and “adulting,” thrown in the mix, adult children are engaging in effortful and intense relationship-building, from which they usually benefit in the form of familial support and love.
Embracing National Daughters Day
In recent years, social media has embraced National Daughters Day with parents posting loving tributes and sharing stories about their daughters, recognition that Alford encourages.
“Adult daughters put a lot of effort into their families and recognizing their hard work with praise and affirmation shows that what they do matters. Every daughter would love to hear compliments on her daughtering,” Alford said, recommending that parents take time on Sept. 25 to acknowledge and thank their adult daughters for the care and time they give to the family.
A few simple ways parents can acknowledge adult daughters:
Also on Sept. 25, Alford and Miller-Day will launch Season 2 of their weekly podcast, “Hello Mother, Hello Daughter,” which continues to explore what it means to be an adult daughter and how daughtering and mothering work together to create a harmonious family.
This season, the hosts interview experts on adult mother-daughter relationship topics and share helpful resources that can enable positive family interactions. The podcast will be available everywhere you listen to podcasts. “Hello Mother, Hello Daughter” also is on social media on Instagram and Facebook.
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Shania Twain is in her fearless era.
The country-pop diva talked about embracing menopause and why she’s proud to be flaunting more than ever in an interview with the New York Post’s Alexa magazine published Wednesday.
Twain ― a five-time Grammy winner with a number of hits to her name, including “That Don’t Impress Me Much” and “Man! I Feel Like a Woman!” ― described the experience as a rewarding challenge.
“I think menopause was a very good thing for me because there were a lot more things changing in everything about me physically that I had to very quickly come to terms with,” Twain, 58, said.
“Menopause taught me to quickly say, ‘You know, it may only get worse. So just love yourself now. Just get over your insecurities — they’re standing in your way. And fear is standing in your way,’” she explained.
“I always sing about being fearless and all of that. I go there when I write. But I’m not living it the way I’m writing it. And I want to live the way I write. I’m more fierce than I ever was because I really demanded it about myself.”
Scott Legato via Getty Images
That new outlook inspired Twain to bare her soul, and more, for the cover of her single “Waking Up Dreaming,” which came out last year.
Talking about her topless, Western-themed photo shoot, she said: “I think I needed to capture where I am right now, because it’s a moment that I want to remember.”
“So I just had to be brave about it, to own it,” she said. “And I felt really good that I felt like, ‘Yeah, I’m OK with that.’ I need to be able to look at myself in the mirror every day. I’m perfectly the way I should be. This is the way I should be at my age. I’m fine with it. And I’m not afraid of it anymore. It’s all good.”
The Canadian singer-songwriter struck a similar tone around the time of the song’s release last year.
“I am a woman in my late 50s, and I don’t need to hide behind the clothes,” she told People magazine. “I can’t even tell you how good it felt to do nude shooting.”
“I was just so unashamed of my new body, you know, as a woman that is well into my menopause,” she said. “I’m not even emotional about it; I just feel okay about it. It’s really liberating.”
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