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The San Francisco 49ers are down bad in terms of injuries.
More news: Is Jauan Jennings Playing? 49ers Get Massive News on Star WR
Quarterback Brock Purdy and tight end George Kittle have already been ruled out of Week 2. The good news is that Purdy might return in Week 3 after reports that he is suffering from a version of turf toe.
Kittle is out for the next four games due to a hamstring injury. The other bit of good news is that receiver Jauan Jennings is expected to suit up. and reports indicated that he was on the field and preparing to do so against the New Orleans Saints.
While there is some good news regarding injuries on the team, the 49ers were just dealt some bad news regarding the status of All-Pro left tackle Trent Williams.
#49ers OT Trent Williams just finished testing his knee out and then a long conversation with OL coach Chris Foerster and members of the training/medical staff. He’s headed back to the locker room now.
— Nick Wagoner (@nwagoner) September 14, 2025
According to 49ers reporter Nick Wagoner, Williams was out on the field and attempting to test out his knee. However, he had a long conversation with offensive line coach Chris Foerster, and went back into the locker room.
Though the 49ers have yet to release their inactives list just yet, signs point to Williams not being able to suit up.
Photo by Ian Maule/Getty Images
More news: 49ers Receive Major Brock Purdy Update Before Week 2 Absence
Williams is just another in the long list of offensive injuries the 49ers are being dealt with at the start of this season.
For Mac Jones, losing Williams will make things far more dangerous in terms of stopping the Saints’ pass rush. At least he will have the chance to dish the ball out to Jennings.
The 49ers were able to pick up a big win against the Seattle Seahawks in Week 1, even with their mounting injuries. They look to do the same against the Saints in Week 2.
Jones will lead the offense, which still has Christian McCaffrey, Ricky Pearsall, and Jennings. However, they will do so without Williams and Kittle.
For more on the 49ers and NFL, head to Newsweek Sports.
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