It’s House of R, mon amis. Mal and Jo are here to give you their thoughts on the season finale, and the season as a whole, of the highly regarded X-Men ’97 (00:00), and what their hopes for the new season may be!
Be sure to check out tickets for the Ringer Residency in Los Angeles this summer!
Hosts: Mallory Rubin and Joanna Robinson Senior Producer: Steve Ahlman Additional Production: Arjuna Ramgopal Social: Jomi Adeniran
Voice performance has become isolating work over the years — these days, for an actor like JP Karliak, a day “on set” is completed from a home studio, and notes come in over Zoom calls. But the goals are the same: find the perfect sound to match a character, and relentlessly chase the perfect take. Karliak has done voice work across the animation and video game spectrum, and is no stranger to IP demands. He’s been in everything from The Boss Baby: Back in Business to Suicide Squad: Kill the Justice League, where he played Batman’s nemesis, Joker. Taking over the role of Morph in Marvel Animation’s X-Men ’97, voiced in the original series by actor Ron Rubin, put him under high pressure from nostalgic fans. Still, alone in the room, he found it: his own pure voice.
“My natural speaking voice doesn’t sound all that different from Ron’s original portrayal,” Karliak tells Polygon, “[and Morph] has a new look, he’s changing. And all these characters are going through all of this plot. For me, it was just sort of like, Why don’t we just sit him in this grounded space, and not slap a character voice on top of it?”
Along with giving Morph a character redesign, the X-Men ’97 writers evolved them into the animated property’s first non-binary character. Karliak, who identifies as genderqueer, was pleased at the change. In the 1990s, using he/they pronouns was less commonplace, but having Rogue make a point of properly addressing Morph in 1997 fits right into the show’s approach to doing whatever feels emotionally right, continuity and era be damned.
“We didn’t fly around and shoot lightning out of our fingers [in 1997 either], so whatever!” Karliak says. “I think the representation is still incredible. And I don’t think it takes away anything from who Morph is. Morph is on a gender journey that will unfold as time passes and he goes through the eras of terminology that we’ve lived through already.”
Image: Marvel Animation
With such a stacked cast, the show doesn’t give Morph a ton of airtime, but their history in the series is deeply felt and considered in each line-reading. X-Men ’97 remains in continuity with X-Men: The Animated Series, which saw Sentinels kill Morph in the first episode, only to have Mister Sinister resurrect the shapeshifter as a brainwashed X-adversary. When his friends rescue him, he disappears from the show again to deal with that trauma.
Morph returns in X-Men ’97 as a goofy but troubled soul finding a place in the world. Karliak says that even if Morph has three lines in an episode, he found himself running through every variation — pure fury, wisecracking, bawling his eyes out, near-deadpan — with voice director Meredith Layne (Castlevania), to give the director and writers what they need to connect the past with present. “As the comic relief of the show, I think he’s burying a lot of things,” Karliak says. “Having him say less was actually the smarter way to go for somebody who’s internalizing a lot.”
Along with voiceover work, Karliak runs the LGBTQIA+ nonprofit Queer Vox, which strives to train aspiring queer VO artists and educate the industry about working with queer talent. He says one quirk of current Hollywood casting is that the group often encounters auditions asking for “non-binary voices,” which he finds funny, despite the attempt at allyship. “It’s like, What does that mean? There’s a lot of conflation of ‘non-binary means androgynous,’ which is not the case,” he says.
And what makes Morph enjoyable for Karliak to bring to life isn’t how the character fits a specific identity slot — it’s how his identity fits into the day-to-day drama at the X-mansion, and the greater global drama of X-Men ’97.
“He’s a superhero who’s got some trauma, he’s got friends, he’s showing up, he’s doing the thing,” Karliak says. “He probably would like to have a significant other at some point — you know, hint, hint, nudge, nudge — and there’s all of that stuff happening. But there’s never a very special Jesse Spano episode of, like, This is the non-binary episode. Because we don’t need it.”
Many fans have wondered whether Morph’s friendship with Wolverine could blossom into something more romantic in future seasons of X-Men ’97. But Karliak hopes it doesn’t, as much as he wants his character to find love.
“As somebody who’s consumed a ton of queer media over the years — what coded things we had in the ’90s — I think there have been so many stories told about the queer person that’s pining over the straight best friend. Meh!” he says. “It’s kind of meh to me! I think it’s so much more interesting that they love each other like they’re Frodo and Samwise, and that’s great. It doesn’t need to be more than that. And they can support each other. It makes Morph razzing Wolverine by turning into Jean Grey so much less about like, Oh, I’m jealous, so I’m gonna, like, razz you about your girlfriend who I hate, and more about, Hey, buddy, I think this is harmful for you, and I just want to point this out, that maybe you need to move on.”
Karliak lauds the X-Men ’97 writers room for breaking from obvious stereotypes and traditions to do its own thing. And the work is standing up to all kinds of scrutiny. When the news broke that Karliak would voice Morph as a non-binary character, the usual corners of the internet erupted with vitriol and found their way into his mentions. But now, with the season wrapped up, he’s hearing little pushback.
“There are properties, movies, IPs that have tried to do queer representation and done it more as checking a box, and it was received badly when it was announced, and continued to be received badly when the thing bombed,” he says. “And I think what’s great about this is that it’s done authentically, not only from the portrayal, but from the writing, like Beau [DeMayo], but also Charley [Feldman] and all of the other writers. There is a queer pedigree that’s going into this to make this right. So the people that shouted about it before it came out — once everybody saw it, and it’s just so universally lauded, it really silenced everything. You can’t argue with excellence.”
Hosts: Charles Holmes, Van Lathan, Jomi Adeniran, and Steve Ahlman Senior Producer: Steve Ahlman Additional Production Support: Arjuna Ramgopal Social: Jomi Adeniran
Hosts: Charles Holmes, Van Lathan, Jomi Adeniran, and Steve Ahlman Senior Producer: Steve Ahlman Additional Production Support: Arjuna Ramgopal Social: Jomi Adeniran
The Midnight Boys also chat about the festivities from Van’s birthday party
The Midnight Boys are back to give you another jam-packed episode. First, they take a look at the latest Deadpool & Wolverine trailer (11:45). Then, they talk about the beautiful finale of Shogun (26:33) as well as the latest episode of X-Men ’97 (67:06). All before finally talking about some of the goings-on that happened at Van’s birthday party (82:03).
Hosts: Charles Holmes, Van Lathan, Jomi Adeniran, and Steve Ahlman Senior Producer: Steve Ahlman Additional Production Support: Arjuna Ramgopal Social: Jomi Adeniran
“The name’s Gambit, mon ami … remember it!” Mal and Jo are back to continue their X-Men ’97 deep dive by breaking down episodes 4-6. They discuss the stakes of the show (18:30) and explain why shame plays such a key role (56:40). Plus, they cover every romance and go over all that happened in the middle three episodes (78:37).
Hosts: Mallory Rubin and Joanna Robinson Producer: Mike Wargon Additional Production: Arjuna Ramgopal Social: Jomi Adeniran
Alex Garland’s Civil War, about reporters covering a conflict in the United States at some unspecified future date, might be the most controversial movie of the year. From the moment the film’s first teaser dropped, Garland, an English writer turned director, was criticized as politically clueless for envisioning a scenario in which a rogue president would be targeted by a coalition of Texas and California (which have nothing in common when they vote in national elections), and also for releasing a film on that subject in the first place during an election year with the same presidential candidates as 2020, one of whom tried to nullify the other’s victory. The discord surrounding the movie increased after its premiere at the South by Southwest Film Festival, where Garland said in interviews that Civil War avoided political specifics on purpose in order to start “a conversation” while refusing to speculate on details the movie didn’t include; instead, he said that it was mainly a love letter to journalists, war reporters in particular. There were also gripes that the film was more violent, slick, and loud than substantive, and perhaps represented an “Emperor’s New Clothes” moment for the director of Ex Machina, Annihilation, and Men, all of which were hotly discussed by genre fans but have yet to form a critical consensus.
Garland spoke to Vulture for an hour in Los Angeles recently, elaborating on his decision to avoid political specifics and what responsibility he has to the 2024 American electorate, and digging into more nebulous questions about the relationships between screenwriting and directing, a movie and its audience, and artists and the eras in which they make art. Garland clarified his decision to step away from — though not, as has been previously reported, entirely quit — directing, saying that it was not driven by criticism of him or his latest film, but in fact dated back to the filming of Civil War two years ago.
How are you feeling right now? Or is that a trick question? It’s a fair question. It’s weird. Selling movies, which is basically what I’m doing, is not normal human interaction. It just isn’t. It’s always a little bit odd. This movie is particularly odd, so it amplifies the weirdness. I can normally relax slightly more when I’m doing interviews, and I’m more guarded, more careful, choosing words more precisely — or attempting to.
I do need to ask you — You can ask whatever you want.
Why would you want to stop directing? It’s a complicated thing. What I said was “for the foreseeable future,” and I mean that in a literal sense. I’m working on four — in a way, five — film projects at the moment, none of which are for me to direct. They’re for other people. So I’m working hard, and I consider screenwriting to be a form of filmmaking. Prior to directing, I functioned as a screenwriter, and I don’t think it’s lesser. I just think it’s other. It has different obligations.
You have a family, yes? Yeah, two kids. I shot a bunch of stuff really back-to-back. I was away a lot, away from home a lot, away from life a lot. That is a contributing factor to the decision. But also I think temperamentally I’m a writer who opted to direct, rather than someone who always had a burning desire to direct. The first film I directed, Ex Machina, I did to protect certain scenes, to not leave them open to discussion.
Alicia Vikander and Domhnall Gleeson in Ex Machina. Photo: Universal Pictures
Protect them from whom? From whoever the director might be. I just wanted to remove that voice for a period of time. And that would have been true with this movie as well. Like, there would be certain scenes in the way they’re unfolding that I would have found impossible to watch if they weren’t unfolding in the right way.
Which scenes in Ex Machina were you concerned about being mishandled or misinterpreted if someone else had directed the movie? It would have had to do with the specificity of some of the dialogue. On the day, in the moment, there might be an actor who suddenly doesn’t feel like a line is fitting in their mouth, and they say, “Hey, can I say it like this?” And the director, who may not understand the exact reason a particular construction of sentences is in there, might say “sure” and then it’s gone and something is lost. There would be many moments in Ex Machina to do with a specific way something is being described.
Did your concerns have to do with the story’s sexual aspects? Absolutely, yeah. It’s a thought experiment I often have: I’ll think of a script and I’ll imagine, What if X directed it? What if Y directed it? What would happen? And in Ex Machina, there was just some stuff that was close to a line and that could not go over a line. It isn’t always the case, but I’ve had a few experiences where stuff in a screenplay was getting changed in a way I couldn’t stomach. Sometimes I would then turn into a kind of pit bull, which I don’t like doing and I don’t want to be. And sometimes I would just have to shrug.
Was it a case where you felt the intent or the quality of the writing had been compromised or mangled? Or was it simply “That’s not how I would have done it”? On occasion, it might be “That’s not how I would have done it.” But often it wasn’t to do with — this is going to sound like a contradiction with what I just said — the exact words; it would be to do with the exact meaning behind the words. You could actually change the dialogue and hold on to the meaning. That would be completely unproblematic. I’ve never cared about that. But the meaning of a scene can completely change, and the role of a scene within a story can completely change.
Can you give me an example? I’d rather not.
Maybe later? Privately, I could do them easily! I could reel them off! But then also you get confronted with another weird thing, right, which is: So the film is not as you intended, but who cares? Does it actually matter? Film is collegial.
In theory! In theory. I think the way I work is pretty collegial! But what will happen is, there will be some things I care about massively, and it has to be that way on that thing. But in and around that thing, there’s enormous latitude to change things, and I’m actually looking for other people to elevate it past the point that I would have been able to consider.
So these four or five new projects you have in the works are all things where you’d be okay with saying, in effect, “Fly little bird, leave the nest, whatever happens is okay”? Correct. It’s to do with … to me, it feels like my last four films as a director are a sequence of films which are following a sequence of thoughts. Civil War, I think, as far as I can tell, ends that sequence.
What is the sequence? Is it “the science-fiction sequence”? “The speculative-fiction sequence”? I probably lean towards science fiction. Fiction is almost by definition speculative —but speculative to degrees, and sci-fi is definitely at the far end of one of those degrees. I also think sci-fi sort of allows for or even encourages big ideas, which is nice. You don’t have to feel embarrassed of them, actually. Sci-fi audiences kind of dig them.
But no, to answer your question, it has more to do with a set of thoughts I had about how to present arguments within a film as conversation. I’m not saying I’m always successful at that, only that it’s a private set of thoughts that I’m following through on.
By “arguments,” do you mean not making a case for or against a thing but rather a dialectical exchange of ideas? Exactly, and a kind of inclusive one. Bear in mind, I’m not saying I always manage to do that. One of the things I have to do is be careful about what I say because that would disrupt the conversation between the film and the audience, you know? I recently watched All That Jazz, which I hadn’t seen for a really, really long time. And while I was watching, I was having what I felt was an intensely personal conversation, I guess, with many people but also with Bob Fosse’s psyche. Would that conversation be helped by Bob Fosse giving me a memo in addition to the film he made? I don’t think it would have helped. I think the film would have been diminished, you know?
I wondered if the reception to Civil War at South by Southwest, as well as the negative or critical reaction to some of your comments in interviews, played into your announcement that you didn’t want to direct anymore. No, no, no, no. The decision predated that. In fact, it located itself in my mind in a clear way while I was shooting Civil War. That’s when I started stating it sometimes to people I work with, just to give them a heads-up: “Hey, I’m gonna be taking some time out for a while, right after this.”
Time out to write? Well, no. It’s slightly more complicated than that because I’m about to do a film with one of the crew from Civil War, a guy called Ray Mendoza, who was our military adviser. In postproduction on Civil War, Ray and I started discussing a film, and I said, “You should direct this because a portion of what directors do is have answers to questions. It’s not the only thing a director does, but it’s a very important part of what a director does.” And in the case of this particular story, the person who has the answers to those questions is Ray, not me. As soon as Ray takes the position of a director, a particular authority is conferred that is then useful for the execution of what he’s talking about. But I also knew there would be some areas that it wouldn’t be fair to expect Ray to have to answer, like, “Why is the camera moving? Should this be a close-up? Should it be a developing shot? Now should we pop out to a wide shot?” So I said, “Let’s share this responsibility.” It’s not directing in the terms I myself would think of as directing.
So a Ray question would be something like “What’s the military objective in this scene, and why are they using this particular type of formation?” Oh, it’s more than that. That would be a Ray question, but it would go well beyond that. This is, in a very profound way, Ray’s story.
What can you tell me about the film? The film is an account of a real event. That’s basically what it is.
An event for which Ray Mendoza was present? Absolutely. Notionally, in a credited way, it’s a co-written script. But really, on my part, it’s an act of transcription and organization rather than what I would normally think of as screenwriting. That will also be true with the directing. Actually, in a way, the writing of the script is an echo of the way I suspect the film will get made.
Let’s return to Civil War for a second. What year is the movie set in, more or less? It’s not, like, five years from now, is it? In my mind, there were some things I was very specific about as a background sequence of events.
I ask because Jesse and Lee have a conversation where Jesse is talking — —about a massacre, and there hasn’t been a massacre in the movie.
Right. She says Lee took famous photos of something called “the antifa massacre.” We don’t know if it was a massacre by antifa or of, but it seems clear that it happened a long time ago, when Jesse was a child or even before her birth. That would mean this story has to be set at least 20 or 25 years from now, right? Yeah. But as for the vehicles, the phones, the sort of textural stuff of real life — a vehicle which is seven years old now is probably not going to be around 25 years from now, right? And there are a lot of vehicles in the film. In that respect, you couldn’t date this story. What you could do is apply a logical sequence of events that are alluded to within the film, which, to my mind, would allow for the situation we see depicted. But you can’t say, “Starting in 2024, here’s what happens: A, B, C, D.” The way in which some people can create huge graphs for a fantasy epic with multiple parts and figure out the laws and the timelines would be a wasted exercise on this movie!
Cailee Spaeny and Kirsten Dunst in Civil War. Photo: A24
All that being said, I don’t know that anything depicted in Civil War is inherently more far-fetched than the 2019 Los Angeles of Blade Runner or Anthony Burgess’s future England in A Clockwork Orange, which, according to the author’s notes for an early draft, was set in 1980. No, it’s certainly not inherently more far-fetched than either of those stories.
It’s interesting: Blade Runner is drifting towards something that is more closely related to our reality because of changes in artificial intelligence. And Clockwork Orange was always closer to reality because it was talking about the haves and have-nots, the Establishment’s fear of violent delinquency, what measures might be taken, whether those measures would work, whether they’d be reactionary or whatever. And that argument, I think, probably belongs to that period. It clearly scared the hell out of Stanley Kubrick at the point when he released the film and thought, Hang on, this is folding into reality quicker and more seriously than I thought possible.
When I rewatched A Clockwork Orange recently I was startled by how much of the grammar of that film has inserted itself into film grammar generally. Kubrick was a freakishly influential filmmaker.
The equivalent of one of those novelists or playwrights who is actually adding words to the language. Is AClockwork Orange the first film where you have a group of young men walking towards the camera in slow motion and then, within the slow motion, a moment of violence floating out? I’m just curious.
One thing we can say for sure is it’s the scene that made a lot of other directors go, “That was cool — I want to do that in my movie.” And they did do it. Scorsese, especially. Let’s go back to Civil War again, though! No, no, I wanna stick with A Clockwork Orange because when I was talking about Civil War being an extension of a sequence of films and something I’ve been working through, bringing in A Clockwork Orange speaks directly to the thing — which is that there’s a disconnect between the intention of a filmmaker and the way a narrative is received. Not only is there a disconnect; it’s a good thing that there’s a disconnect because it involves the imaginative life and it’s built into the terms of conversation. Everything I say to you and you say to me, just in our talking, may not be fully understood either way. Conversation is in some respects impressionistic. It’s connected but impressionistic. And film is a really good exercise in demonstrating that. Clockwork Orange, for example, should mean either slightly or very different things to different people, and that is in no way problematic.
Speaking of problematic: There were complaints after the trailers and after the South by Southwest premiere that it was unrealistic to think California and Texas could be allied against the president because California votes Democratic in national elections and Texas votes Republican. I explained it to myself as, well, there are large numbers of Republicans in California who hate the rest of the state and want to secede; maybe they’ve seceded or taken over by that point in history, and that’s why California is allied with Texas. But maybe I’m wrong? One of the reasons the film does not specify the reasons behind Texas and California is to consciously, deliberately leave that space as a source of engagement.
So my speculative interpretation — Is as valid as mine.
And it’s not necessarily wrong? It is explicitly not necessarily wrong. What I would say is that all the thoughts put together, I hope — whatever disagreements you and I might have — a consensus would arrive from those things. Which, because I’m a fucking science nerd, I’m going to demonstrate to you now. [Garland takes out his phone and calls up the screenshot below.]
Photo: Galton Board App
Okay, what are we looking at here? What we’re looking at is a Galton Board. It’s a series of ball bearings falling and it’s a random 50-50 on which sides of each of these shapes they bounce. But a consensus appears as a product of the accumulated states. That orange line shows the state of the consensus.
So if you applied this to an audience’s reaction to a film, could this Galton Board perhaps represent the fullness of time rendering a consensus verdict? This is how I’m feeling watching All That Jazz. Bob Fosse might be there [points to the left side of the board], I might be there [points to the right side of the board], but this is the shape [points to the peak in the middle].
What do you make of the obsession with “solving” ambiguous endings and filling in every last bit of imaginative negative space in a story with explanations, backstory, and lore? Seems anti-art to me. I totally agree, but it’s worth pointing out that even if you do attempt to fill every single gap in a narrative, you will still not get this perfect, harmonious, unified response to every single moment and every single beat. It just never appears! The quest is quixotic, you know? I think most mainstream movies do exactly what you said, and they are open to less interpretation than the other kind. But I suspect if you go on any film website, you’ll see fans angrily arguing over the meaning in a movie that already explains everything.
Refusing to explain everything is not a flaw. But it sure does make people mad! The most satisfying film I saw last year was Anatomy of a Fall. It really does not answer one of its own central questions, and that in no way bothered me. In fact, I liked it even more for not answering it. But then there’ll be other people who walk out and throw their hands up in disgust going, “What the fuck? Did she do it or not?”
That’s funny because there are people who will insist that the film does in fact give you an answer, just as there are people who insist Zodiac gives you a clear idea of who the Zodiac killer was. That would be another subjective response. Here’s another thing that’s interesting: I just don’t really care what the filmmakers say, personally. But what if the filmmakers say, “No, no, we gave an answer — it’s there, it’s this,” but I didn’t see it? Does that mean I saw the film incorrectly? I don’t think so.
I don’t know. But I do know that sometimes my misreadings of a film are as interesting to me as what the film is actually saying, because of what it reveals to me about myself. Exactly. My whole journey over this sequence of films was a playing out of exactly what you just said. I felt with Civil War, this is as good as I will ever be able to do.
Are you comfortable saying what the film is about in a very general way? What I can say is that Civil War is about a state. I don’t mean a state like a country; I mean a state of thinking, which is divided and contains a path to forms of extremism so there is something of the real world located within it.
Every science-fiction film is about the time in which it was made. For sure. That’s one of the reasons I love sci-fi.
Therefore, Civil War is about our time too? Yeah, I hope so — and I hope so in a kind of thoughtful and conversational manner.
What would you say to somebody who accuses you of being irresponsible for making a film like Civil War and releasing it during an election year? The truest thing I’d say about that is I honestly don’t know whether it’s responsible or irresponsible because I would need to know too many things I don’t know in order to be able to answer that question. But what I do think is that there’s a converse, a counter to that, which is “What’s the consequence of not saying things? What’s the consequence of silence? Of silencing oneself or silencing other people?”
What is the film warning us about? Two things. If I was going to be reductive in a way, and I’m not inclined to be reductive, I would say that — paradoxically, considering the subject matter — the film is about journalism. It’s about the importance of journalism.It’s about reporting. The film attempts to function like old-fashioned reporters. That’s thing No. 1.
What’s the other thing? Just a simple acknowledgment that this country, my country, many European countries, countries in the Middle East, Asia, South America, all have populist, polarized politics which are causing and magnifying extreme divisions, and the end state of populism is extremism and then fascism.
That relates back again to journalists because you have governments with checks and balances, but you need this other thing, which is the press — free, fair, but also trusted. And at the moment, the dominant voices in the press are not trusted. They’re trusted to a degree by the choir they’re preaching to but not by the other choirs. I’m in my 50s. When I was a kid, if in what the old days was called a “broadsheet newspaper” ran a story about a corrupt or lying politician, it didn’t matter whether you were a reader of that newspaper or not, the impact would be enormous and very likely would end that person’s career. That world has gone.
It’s funny because so many movies still end with a video or audio recording being played publicly to prove that someone is corrupt, and the implication is that the bad person was fired or sent to prison. It worked perfectly in a 1970s paranoid conspiracy thriller because the heroes got the story out, and the sinister government course or the sinister corporate course was screwed by the story having come out.
Why is that kind of ending hard to accept now? It’s a consequence of three things. One is powerful external forces: politicians who deliberately undermine trust in the media for their own ends because it’s useful for them to have the media be distrusted. Social media creates an enormous amount of noise and counternarratives and theories that just create a kind of static over all of the information; it has a tonal quality which is often akin to shouting. And then also, very large, very powerful media organizations, which found themselves driven less ideologically than by advertising, needing to target audiences and hold on to those audiences. That became more important than unbiased news reporting.
It’s easier to get people to listen to your message if it’s one they already agree with? Yes, and that works very well. But it doesn’t work well for everyone who sits outside of that audience.
How does this relate back to the mentality of the journalists you depict in Civil War? They’re reporters. They’re reporters. The era I grew up in was an era of reporters in news journalism.
It doesn’t seem to matter to the reporters in Civil War if they’re embedded with the good guys or the bad guys. Why would it? They’re reporters.I think we need those kinds of people because we need for journalists to be trusted because they are the people that hold governments to account. And governments will, at times, regularly, predictably become corrupt.
What was the influence of your father, who was an editorial cartoonist, not just on this movie but on who you are? Huge. In two really significant ways. Every night Dad would watch the nine o’clock news because he’d be looking for a story that he’d do a cartoon about the next day. All of — not all, but the vast majority of — his close friends were journalists. My godfather was a foreign correspondent; my brother’s godfather was a different foreign correspondent. They were around the kitchen table; they were sometimes living in the house. I grew up listening to them. Like the journalists in this movie, they could be spiky, they could be difficult, they could be compromised or conflicted, but there was a kind of purity in this one aspect of their work that they were deadly serious about.
The other thing is Dad was a cartoonist, so I grew up around drawing, and I grew up around comic books. Comic books are sequences of images, and that’s, basically, even as a screenwriter, I am offering up sequences of images and editorial decisions. The scene ends here, and this image contrasts with the thing you just saw, and that carries its own implicit meaning or complication.
It’s so interesting hearing you talk about your father’s influence and journalism because, now that I think about it, your films feel reported. Like you’re going, “Here are the characters, here are the issues they have conflicts over, here is the story, here is the ending. Whatever you make of all this is up to you because I’m on to the next thing.” That’s exactly it. And I am aware that the attitude pisses some people off because they want the reassurance of knowing where the filmmaker stands with regard to various issues.
I remember when Ex Machina came out, I had arguments with people about the ending, where Ava leaves Caleb trapped. Some people wanted her to take him along or at least free him. How do you feel about that? Her point of empathy was the robot played by Sonoya Mizuno. Those two empathize with each other. They were in the same boat. She was in a prison; she was trying to get out. Kyoto, Sonoya’s character, empathizes with Ava. That would be my answer. But I find it interesting that people said it was cruel or non-empathetic, that it proves AIs don’t have empathy. I was like, “Empathy with who?”
It’s astonishing to me that Ex Machina came out ten years ago. You have a sequence where the creator, Nathan, takes Caleb into the laboratory and talks about how he used his power as a tech billionaire to basically eavesdrop on every communication in the world to create this AI. That’s what’s in the news now, that very thing: the scraping of information without consent or compensation to create an agglomeration that machines plug into. I always felt a real skepticism with these tech leaders. Because they work in tech, we make an assumption that they’re geniuses, and they’re very quick to also make that assumption about themselves. And I sort of think, Eh, you’re entrepreneurs. It just so happens that you’re not in milk production; you’re making social media or whatever the hell it is. That doesn’t confer on you any special status at all. And as the years roll by, that’s the other thing that’s been demonstrated — they’re really not geniuses. They’re just people with a lot of money and a lot of power. That in itself doesn’t make a genius.
Was Ex Machina a warning? I definitely thought about it in those terms. It was actually in the TV show Devs that I really went further down that line. In fact, one of the characters in Devs, one of the computer programmers, says he’s not a genius, he’s an entrepreneur.
Do you ever read the news and think, Yeah, I called it? I never think my stuff is prescient. I know there’s a big conversation happening about these issues at exactly the same time that I write things, so I know it’s not prescient; it’s more sort of factual. I think people are very, very good at correctly anticipating problems. They’re just terrible at doing something about it. They just don’t act.
I organized two screenings of Annihilation, and afterward, the audience had an astounding number of different interpretations of the film: that it was about the uncertainty principle, that it was about grief, that it was a metaphor for cancer. There were assorted theological readings. I wondered if you had a specific reason for making that movie. If I was going to be very reductive about Annihilation, it would probably be about self-destruction, that that could include cancer or behavior or any number of things. But this is true of all the films I make: It’s not one goal, one thing; it’s a set of thoughts. Ex Machina is that too, explicitly. It’s just easier for me to talk about the things that are explicit, like machine sentience, rather than the things I hope will float out, such as gender — where gender resides, whether it’s conferred or taken, that kind of thing.
Another thing I noticed about your movies, as both writer and writer-director, is that they are filled with people choosing to place themselves in harm’s way, whether they’re Ava trying to escape the complex, or the journalists in Civil War, or the crew in Sunshine trying to plant a bomb that will reawaken the Sun. That’s quite interesting.I’ll refrain from talking too much about that and getting a bit autobiographical, but I do sometimes think there’s a part of me that is thoughtful and there’s a part of me that is delinquent. And I can see the delinquency.
What do you mean? Delinquent in the “potential droog” sense, or in some other sense? Holistic.
Holistically delinquent? In some respects. You know, people have different sides to their personality and character. I can see it clearly in Civil War. It’s thoughtful and it’s conversational, and I think it would be fair to say it’s also highly aggressive. The two things are just right next to each other. In these films, there’s something very restrained and also something unrestrained.
That’s also true of 28 Days Later. Danny Boyle and I like working on a long-term sequel to that. He’s in prep now, and it starts shooting pretty soon.
What a shitshow it must be in that world 28 years later! Well, in some ways yes, but in some ways no. We had a kind of deal between us, which was to not be cynical, and I think both of us are sticking pretty hard to that principle.
You called yourself a science geek earlier, and you obviously enjoy getting philosophical, but you’re not much for explanations, are you? I don’t have any explanations! The larger the searchlight, the larger the circumference of the unknown.
Titled Warfare, the film is rumored to be a dramatization of events that occurred during the Iraq War in 2006 and that earned Mendoza, a former Seal Team 6 member, a Silver Star “for conspicuous gallantry and intrepidity in action against the enemy.” The cast includes Noah Centineo, Taylor John Smith, Adain Bradley, Michael Gandolfini, Henrique Zaga, and Evan Holtzman.
The world has gone mad, and the boys are back to make sense of it all. Van, Charles, Jomi, and Steve break down their thoughts on the maddening trailer for Joker: Folie à Deux (09:13). Then they take a look at the fifth explosive episode of X-Men ’97 (33:29). That’s all before they dive into this week’s episode of Shogun (57:43).
Hosts: Charles Holmes, Van Lathan, Jomi Adeniran, and Steve Ahlman Senior Producer: Steve Ahlman Additional Production Support: Arjuna Ramgopal Social: Jomi Adeniran
It’s time to tap into the animation sensation that is Invincible for its Season 2 finale! The Midnight Boys talk about what made the season overall a little different this time around (14:08). Then they tap back into the captivating Shogun and what they think may happen leading into the finale (55:38). And finally, they take on the drama between Storm and Forge in this week’s X-Men ’97 (88:55).
Hosts: Charles Holmes, Van Lathan, Jomi Adeniran, and Steve Ahlman Senior Producer: Steve Ahlman Additional Production Support: Arjuna Ramgopal Social: Jomi Adeniran
CHICAGO — Two men and a woman were seriously injured in an early-morning drive-by shooting on the South Side.
Chicago police say the shooting happened in the 100 block of East 47th Street, in Grand Boulevard, at around 4 a.m. on Sunday.
The three victims, a 23-year-old woman, an 18-year-old man and a 30-year-old man were sitting inside a car at a stop light in the area when another vehicle appraised and someone inside opened fire.
All three victims were hit by gunfire and were taken to the hospital in serious condition.
Currently, it is unclear what led to the shooting and authorities say no arrests have been made.
An investigation is now underway.
Anyone with information on the shooting is asked to contact CPD Area One detectives at 312-747-8380 or dial 911.
Those with information that could help authorities in their investigation can also leave a tip at CPDtip.com. Tips can be filed anonymously.
“This was legitimately one of the best friends I’ve had in my entire life — he was in my wedding party, we vacationed together, our kids grew up together — and I didn’t know his name.”
In a world where social bonds are seen as a fundamental aspect of human life, the diminishing circle of close friends among adult men is becoming a subject of increasing concern. As a psychotherapist of 20 years specializing in men’s issues and relationships, my colleagues and I see this phenomenon firsthand. We’re worried. Research highlights a startling reality: men are simply less satisfied with their friendships as compared to women. With less than 50% of men content with their friendships and only 20% receiving emotional support from friends in any given week, the comparison with 40% of women is stark.
The decline in men’s friendships often starts during adolescence and becomes more pronounced with age. While boys don’t inherently lack the ability to emotionally connect, they often grow into men who are emotionally distant. Really all humans possess an innate need for close connections, with those connections being crucial for not only our development but for our survival.
The impact of loneliness
A significant consequence of the lack of intimate friendships – loneliness – can be as detrimental to our health as obesity or smoking. When men feel alone and disconnected, the effects can become quite real and incredibly impactful.
Acknowledging this emotional distress would not only improve well-being but also reduce loneliness. However, men are often unaware of the deep importance of sharing their suffering with loved ones, friends, colleagues, or even mental health providers.
The problem is rooted in the traditional norms of masculinity which often discourage the expression of vulnerability, an essential component of deep friendships. For decades, the stigma surrounding male bonding has been a barrier. This is further complicated by entrenched gender roles that valorize stoicism and independence, often at the expense of emotional openness and interdependence.
Man up
The consequence of such a culture is not just the evident loneliness but an increased propensity for anger and violence. It is often times why men struggle with close connections.
We find ourselves in a societal paradox where our nurturing instincts clash with the expectations of “manning up”. By forcing boys to conform to these restrictive norms, we absolutely set them up for struggles in adult life.
Additionally, the over-reliance on romantic partners for emotional support can strain relationships. It’s vital to cultivate a community for varied perspectives and support, yet many males often press forward in their romantic relationships with the expectation that a primary partner can and should meet all of their emotional needs. The challenge lies not just in seeking support from a variety of other humans, but in offering that support by being vulnerable, authentic, and transparent. These are traits that are often mistakenly viewed as weakness rather than strength.
Impact of digital communication
Modern communication methods, like texting and social media, often hinder deeper conversations. Men, who might already be less inclined to share emotions, may find digital platforms inadequate for expressing their feelings authentically, and for those who do open up emotionally through electronic means, this medium for communication and connection can impede the importance of face-to-face interactions.
It may feel less anxiety-producing to talk openly through type, but cultivating and deepening friendship through this format doesn’t help to train young male brains to be in-person with another human, where eye-contact and other non-verbals are fundamental ways that we relate. Men need to learn to live with the anxiety that can come with being in a shared space with another person, where interactions are dynamic and in real-time, rather than allowing for the carefully-crafted and edited written responses that our devices afford us.
Case study: Me
As someone in the profession of talking to people all day, you might assume a male therapist has a relatively easy go of developing close personal connections and solid friendships. Perhaps others do, but I’ve found that I too grapple with many of the same challenges outlined in this post.
I’m reminded of 20 years ago in grad school when a male classmate and I would find ourselves using the 15-minute break to go outside for some fresh air. The first few times we found ourselves simultaneously loitering outside the school, we did what two men typically do: a brief head nod of acknowledgment, but otherwise pretending the other simply wasn’t there. But I found this person intriguing, having heard his comments during class. I wondered if this could be someone I might connect with, so one day took a chance and struck up what started out as an awkward conversation.
Without discussing it, we seemed to have an understanding that during each of those breaks for the rest of the quarter, we would use that time to chat. We made enough of a connection that he was the next one to take a chance by suggesting we go get coffee. Coffee became the occasional lunch, which one of us at some point suggested should next be dinner with our spouses at a restaurant, which eventually became dinner parties at each other’s homes.
Today, this guy is one of my very favorite people on the planet, and a friendship that my wife and I have immense gratitude for. But it couldn’t have taken root if he and I hadn’t each been willing to brave the vulnerability of exploring the possibility of deep, meaningful connection, and investing the time and energy it takes to cultivate rewarding and lasting friendship.
Deepening our connections
Building deeper male friendships requires a shift from mere pleasantries to meaningful engagement. Here are some suggestions for how to do so:
Ask real questions of your friends;
Show genuine interest;
Be present (put your phone away during interactions);
Find shared activities that provide face-to-face, or at least side-by-side, connection that fosters camaraderie.
Starting small and being intentional is key. Initiating an invite for coffee or engaging in a shared hobby can lay the groundwork for stronger bonds. It’s about quality over quantity, where a few meaningful friendships can have a significant impact on one’s well-being.
It’s essential for men to recognize the importance of cultivating deep friendships, not as a societal expectation but as a personal health imperative. By challenging outdated stereotypes and embracing vulnerability, men can build the emotionally supportive networks they need. It’s time to redefine masculinity, not as a barrier to intimacy, but as a bridge to stronger, healthier human connections.
Newswise — Certain populations of mosquitoes are more heat tolerant and better equipped to survive heat waves than others, according to new research from Washington University in St. Louis.
This is bad news in a world where vector-borne diseases are an increasingly global health concern. Most models that scientists use to estimate vector-borne disease risk currently assume that mosquito heat tolerances do not vary. As a result, these models may underestimate mosquitoes’ ability to spread diseases in a warming world.
Researchers led by Katie M. Westby, a senior scientist at Tyson Research Center, Washington University’s environmental field station, conducted a new study that measured the critical thermal maximum (CTmax), an organism’s upper thermal tolerance limit, of eight populations of the globally invasive tiger mosquito, Aedes albopictus. The tiger mosquito is a known vector for many viruses including West Nile, chikungunya and dengue.
“We found significant differences across populations for both adults and larvae, and these differences were more pronounced for adults,” Westby said. The new study is published Jan. 8 in Frontiers in Ecology and Evolution.
Westby’s team sampled mosquitoes from eight different populations spanning four climate zones across the eastern United States, including mosquitoes from locations in New Orleans; St. Augustine, Fla.; Huntsville, Ala.; Stillwater, Okla.; St. Louis; Urbana, Ill.; College Park, Md.; and Allegheny County, Pa.
The scientists collected eggs in the wild and raised larvae from the different geographic locations to adult stages in the lab, tending the mosquito populations separately as they continued to breed and grow. The scientists then used adults and larvae from subsequent generations of these captive-raised mosquitoes in trials to determine CTmax values, ramping up air and water temperatures at a rate of 1 degree Celsius per minute using established research protocols.
The team then tested the relationship between climatic variables measured near each population source and the CTmax of adults and larvae. The scientists found significant differences among the mosquito populations.
The differences did not appear to follow a simple latitudinal or temperature-dependent pattern, but there were some important trends. Mosquito populations from locations with higher precipitation had higher CTmax values. Overall, the results reveal that mean and maximum seasonal temperatures, relative humidity and annual precipitation may all be important climatic factors in determining CTmax.
“Larvae had significantly higher thermal limits than adults, and this likely results from different selection pressures for terrestrial adults and aquatic larvae,” said Benjamin Orlinick, first author of the paper and a former undergraduate research fellow at Tyson Research Center. “It appears that adult Ae. albopictus are experiencing temperatures closer to their CTmax than larvae, possibly explaining why there are more differences among adult populations.”
“The overall trend is for increased heat tolerance with increasing precipitation,” Westby said. “It could be that wetter climates allow mosquitoes to endure hotter temperatures due to decreases in desiccation, as humidity and temperature are known to interact and influence mosquito survival.”
Little is known about how different vector populations, like those of this kind of mosquito, are adapted to their local climate, nor the potential for vectors to adapt to a rapidly changing climate. This study is one of the few to consider the upper limits of survivability in high temperatures — akin to heat waves — as opposed to the limits imposed by cold winters.
“Standing genetic variation in heat tolerance is necessary for organisms to adapt to higher temperatures,” Westby said. “That’s why it was important for us to experimentally determine if this mosquito exhibits variation before we can begin to test how, or if, it will adapt to a warmer world.”
Future research in the lab aims to determine the upper limits that mosquitoes will seek out hosts for blood meals in the field, where they spend the hottest parts of the day when temperatures get above those thresholds, and if they are already adapting to higher temperatures. “Determining this is key to understanding how climate change will impact disease transmission in the real world,” Westby said. “Mosquitoes in the wild experience fluctuating daily temperatures and humidity that we cannot fully replicate in the lab.”
Sean, Amanda, and Chris explore the high highs of Ridley Scott’s Napoleon—in particular the battle scenes—while trying to sort through their feelings on why the movie doesn’t come together as a whole quite how they hoped it would (1:00). Then, they try to place Napoleon in the historical context of “great men” movies and share their top five in the genre (40:00).
Hosts: Sean Fennessey and Amanda Dobbins Guest: Chris Ryan Senior Producer: Bobby Wagner
Newswise — روتشستر، مينيسوتا — يُعَّد هذا مصدر قلق شائع بين الرجال الذين شُخِّصَت إصابتهم بسرطان الخصية. هل سأكون قادرًا على إنجاب أطفال في المستقبل؟
يقول برادلي ليبوفيتش، دكتور في الطب، طبيب أورام المسالك البولية في مايو كلينك: “عندما نُقيِّم الرجال المصابين بسرطان الخصية المشتبه به الجديد، فإننا نتحدث بالفعل عن الخصوبة”.
يقول الدكتور ليبوفيتش إن أحد أهم الأسئلة التي يسمعها من الرجال المصابين بسرطان الخصية: هل لا يزال بإمكاني إنجاب الأطفال؟
يقول الدكتور ليبوفيتش: “لدى الرجال المصابين بسرطان الخصية مخاوف تتعلق بالخصوبة لأن سرطان الخصية نفسه يمكن أن يؤثر على الخصوبة ويمكن أن تؤثر علاجاتنا على الخصوبة”. “أول شيء نفعله مع الرجال المهتمين بالحفاظ على الخصوبة هو الحديث عن بنك الحيوانات المنوية،”
يمكن أن يكون العقم من الآثار الجانبية للجراحة والمعالجة الكيميائية والإشعاعية وعلاجات السرطان الأخرى. هذا هو السبب في أنه من المهم للرجال الذين ما زالوا يرغبون في إنجاب الأطفال بعد علاج السرطان أن يحفظوا حيواناتهم المنوية قبل بدء العلاج.
يقول الدكتور ليبوفيتش: “عادة ما نعالج مشكلات الخصوبة بشكل مسبق من خلال التأكيد على بنك الحيوانات المنوية للرجال، لذلك من النادر أن يكون ذلك مصدر قلق للرجال على المدى الطويل”.
مصدر قلق آخر هو انخفاض مستويات هرمون التستوستيرون، وهو هرمون يُنتَج بشكل أساسي في الخصيتين.
“يحظى معظم الرجال بمستويات طبيعية من هرمون التستوستيرون بخصية واحدة فقط. وبالنسبة للرجال الذين ينتهي بهم الأمر بمستوى أقل من هرمون التستوستيرون، من السهل حقًا استخدام بدائل له”، كما يقول الدكتور ليبوفيتش.
تحت إشراف أخصائي الرعاية الصحية، يمكن لـ العلاج ببدائل التستوستيرون، على شكل حقن أو حبوب أو لصقات جلدية أو مواد هلامية، استعادة مستويات هرمون التستوستيرون الطبيعية لدى الرجال.
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نبذة عن مايو كلينك مايو كلينك هي مؤسسة غير ربحية تلتزم بالابتكار في الممارسات السريرية والتعليم والبحث وتوفير التعاطف والخبرة لكل مَن يحتاج إلى الاستشفاء والرد على استفساراته. لمعرفة المزيد من أخبار مايو كلينك، تفضَّل بزيارة شبكة مايو كلينك الإخبارية.
Newswise — ROCHESTER, Minnesota — Esta es una preocupación común entre los hombres que reciben un diagnóstico de cáncer testicular. ¿Podré tener hijos en el futuro?
“Cuando evaluamos por primera vez a hombres que podrían padecer un cáncer testicular nuevo, hablamos de fertilidad”, dice el Dr. Bradley Leibovich, oncólogo urólogo de Mayo Clinic.
El Dr. Leibovich dice que es una de las principales preguntas que escucha de los hombres con cáncer testicular: ¿Aun así puedo tener hijos?
“Los hombres con cáncer testicular tienen problemas de fertilidad porque este cáncer en sí mismo puede afectar la fertilidad y nuestros tratamientos pueden afectar la fertilidad”, dice el Dr. Leibovich. “Lo primero que hacemos con los hombres que están interesados en preservar la fertilidad es hablar sobre bancos de esperma”,
La infertilidad puede ser un efecto secundario de la cirugía, la quimioterapia, la radiación y otros tratamientos contra el cáncer. Por eso es importante que los hombres que aún deseen tener hijos después de curarse guarden su esperma antes de comenzar el tratamiento.
“Por lo general, abordamos los problemas de fertilidad desde el principio asegurándonos de que los hombres tengan un banco de esperma, por lo que es raro que sea una preocupación a largo plazo para ellos”, dice el Dr. Leibovich.
Otra preocupación son los niveles bajos de testosterona, una hormona que se produce principalmente en los testículos.
“La mayoría de los hombres tiene niveles normales de testosterona con solo un testículo. En el caso de los hombres que acaban con un nivel bajo de testosterona, es muy fácil de reemplazar”, dice el Dr. Leibovich.
Bajo la orientación de un profesional de atención médica, la terapia para reemplazo de la testosterona, en forma de inyecciones, píldoras, parches o geles, puede restaurar los niveles normales de testosterona en los hombres.
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Información sobre Mayo Clinic Mayo Clinic es una organización sin fines de lucro, dedicada a innovar la práctica clínica, la educación y la investigación, así como a ofrecer pericia, compasión y respuestas a todos los que necesitan recobrar la salud. Visite la Red Informativa de Mayo Clinic para leer más noticias sobre Mayo Clinic.
Newswise — ROCHESTER, Minnesota — Uma preocupação comum entre os homens diagnosticados com câncer testicular é expressa por essa dúvida. Serei capaz de ter filhos no futuro?
“Quando avaliamos pela primeira vez os homens com uma nova suspeita de câncer testicular, falamos sobre fertilidade”, explica o Dr. Bradley Leibovich, oncologista urológico na Mayo Clinic.
O Dr. Leibovich afirma que uma das primeiras perguntas que ele escuta dos homens com câncer testicular é a seguinte: ainda poderei ter filhos?
“Homens com câncer testicular têm preocupações em relação à fertilidade, pois a doença propriamente dita, além de nossos tratamentos, podem afetar a fertilidade”, explica o Dr. Leibovich. “A primeira coisa que fazemos com os homens interessados em preservar a fertilidade e falar sobre os bancos de sêmen.”
A infertilidade pode ser um efeito colateral da cirurgia, quimioterapia, radiação e de outros tratamentos de câncer. É por isso que é importante para os homens que ainda desejam ter filhos após a cura do câncer, que armazenem o sêmen antes de iniciar o tratamento.
“Problemas de fertilidade normalmente são abordados de antemão, garantindo que os homens tenham um banco de sêmen, por isso é raro que seja uma preocupação de longo prazo para os homens”, explica o Dr. Leibovich.
Outra preocupação são os baixos níveis de testosterona, um hormônio produzido principalmente nos testículos.
“A maioria dos homens tem níveis normais de testosterona com apenas um testículo. Para os homens que acabam apresentando um nível mais baixo de testosterona, é muito fácil repor,” explica o Dr. Leibovich.
Sob a orientação de um profissional de saúde, a terapia de reposição de testosterona, na forma de injeções, pílulas, adesivos ou gel, pode restaurar os níveis normais de testosterona nos homens.
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Sobre a Mayo Clinic A Mayo Clinic é uma organização sem fins lucrativos comprometida com a inovação na prática clínica, educação e pesquisa, fornecendo compaixão, conhecimento e respostas para todos que precisam de cura. Visite a Rede de Notícias da Mayo Clinic para obter outras notícias da Mayo Clinic.
Newswise — Does electromagnetic radiation emitted by mobile phones affect semen quality? While various environmental and lifestyle factors have been proposed to explain the decline in semen quality observed over the last fifty years, the role of mobile phones has yet to be demonstrated. A team from the University of Geneva (UNIGE), in collaboration with the Swiss Tropical and Public Health Institute (Swiss TPH), has published a major cross-sectional study on the subject. It shows that frequent use of mobile phones is associated with a lower sperm concentration and total sperm count. However, researchers did not find any association between mobile phone use and low sperm motility and morphology. Read the results in Fertility & Sterility.
Semen quality is determined by the assessment of parameters such as sperm concentration, total sperm count, sperm motility and sperm morphology. According to the values established by the World Health Organization (WHO), a man will most probably take more than one year to conceive a child if his sperm concentration is below 15 million per milliliter. In addition, the percentage chance of pregnancy will decrease if the sperm concentration is below 40 million per milliliter.
Many studies have shown that semen quality has decreased over the last fifty years. Sperm count is reported to have dropped from an average of 99 million sperm per millilitre to 47 million per millilitre. This phenomenon is thought to be the result of a combination of environmental factors (endocrine disruptors, pesticides, radiation) and lifestyle habits (diet, alcohol, stress, smoking).
Assessing the impact of mobile phones
Is the mobile phone also to blame? After conducting the first national study (2019) on the semen quality of young men in Switzerland, a team from the University of Geneva (UNIGE) has published the largest cross-sectional study on this topic. It is based on data from 2886 Swiss men aged 18 to 22, recruited between 2005 and 2018 at six military conscription centres.
In collaboration with the Swiss Tropical and Public Health Institute (Swiss TPH), scientists studied the association between semen parameters of 2886 men and their use of mobile phones. ‘‘Men completed a detailed questionnaire related to their lifestyle habits, their general health status and more specifically the frequency at which they used their phones, as well as where they placed it when not in use,’’ explains Serge Nef, full professor in the Department of Genetic Medicine and Development at the UNIGE Faculty of Medicine and at the SCAHT – Swiss Centre for Applied Human Toxicology, who co-directed the study.
These data revealed an association between frequent use and lower sperm concentration. The median sperm concentration was significantly higher in the group of men who did not use their phone more than once a week (56.5 million/mL) compared with men who used their phone more than 20 times a day (44.5 million/mL). This difference corresponds to a 21% decrease in sperm concentration for frequent users (>20 times/day) compared to rare users (<1 time>
Is 4G less harmful than 2G?
This inverse association was found to be more pronounced in the first study period (2005-2007) and gradually decreased with time (2008-2011 and 2012-2018). ‘‘This trend corresponds to the transition from 2G to 3G, and then from 3G to 4G, that has led to a reduction in the transmitting power of phones,’’ explains Martin RÖÖsli, associate professor at Swiss TPH.
‘‘Previous studies evaluating the relationship between the use of mobile phones and semen quality were performed on a relatively small number of individuals, rarely considering lifestyle information, and have been subject to selection bias, as they were recruited in fertility clinics. This has led to inconclusive results,’’ explains Rita Rahban, senior researcher and teaching assistant in the Department of Genetic Medicine and Development in the Faculty of Medicine at the UNIGE and at the SCAHT, first author and co-leader of the study.
It doesn’t matter where you put your phone
Data analysis also seems to show that the position of the phone – for example, in a trouser pocket – was not associated with lower semen parameters. ‘‘However, the number of people in this cohort indicating that they did not carry their phone close to their body was too small to draw a really robust conclusion on this specific point,’’ adds Rita Rahban.
This study, like most epidemiologic studies investigating the effects of mobile phone use on semen quality, relied on self-reported data, which is a limitation. By doing so, the frequency of use reported by the individual was assumed to be an accurate estimate of exposure to electromagnetic radiation. To address this limitation, a study funded by the Federal Office for the Environment (FOEN) was launched in 2023. Its aim is to directly and accurately measure exposure to electromagnetic waves, as well as the types of use – calls, web navigation, sending messages – and to assess their impact on male reproductive health and fertility potential. The data will be collected using an application that each future participant will download to their mobile phone. The research team is actively recruiting participants for this study.
The aim is also to better describe the mechanism of action behind these observations. ‘‘Do the microwaves emitted by mobile phones have a direct or indirect effect? Do they cause a significant increase in temperature in the testes? Do they affect the hormonal regulation of sperm production? This all remains to be discovered,’’ concludes Rita Rahban.
Newswise — Bonn, 27. October – Mature spermatozoa are characterized by an head, midpiece and a long tail for locomotion. Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit “Life & Health” at the University of Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice. The cells can no longer develop their characteristic shape and remain in a rather round form. The animals are infertile. The results of the study have now been published in the scientific journal “Development”.
Male sperm cells are constantly produced in large quantities in the testicles during so-called spermatogenesis. In this process, the typical elongated sperm cells are formed from round germ cells. This enormous change in shape requires the fine tuned reorganization of specialized structural proteins. One of these structural proteins is ACTL7B. “Since it is exclusively made in humans and mice during the maturation of male sperm, it has been postulated that the protein is important for this phase of development,” notes corresponding author Prof. Hubert Schorle from the Institute of Pathology at UKB, who is also a member of the Transdisciplinary Research Area (TRA) “Life & Health” at the University of Bonn.
To investigate the role of the structural protein in spermiogenesis, Prof. Schorle’s team generated a mouse model with a mutation in the Actl7b gene using gene-editing technology. This results in a complete loss of function of ACTL7B. “Without ACTL7B, development is blocked, the cells often remain in a roundish shape, usually do not form the elongated, typical sperm shape and die to a large extent ,” says first author Gina Esther Merges, a doctoral student in Professor Schorle’s laboratory.
Disruption in the network of proteins
In this context, the Bonn researchers found that ACTL7B is required for the reorganization of the cytoskeleton of spermatids. Using mass spectrometric analyses, they identified two interaction partners of ACTL7B, DYNLL1 and DYNLL2. “We were able to show that without the structural protein, DYNLL1 and 2 are not correctly localized in the round spermatids. Since it is probably a larger protein complex with further interaction partners, we attribute the above described effect to a loss of temporally and spatially precisely regulated and targeted redistribution of these proteins,” Prof. Schorle notes.
This explains why the sperm of male mice with a mutated Actl7b gene is not able to develop the characteristic shape. Due to this, the animals are infertile. In addition, according to other research, there is evidence that levels of the protein ACTL7B are reduced in some fertility patients. “Our study shows that mutations in the Actl7b gene could be the cause of male infertility,” says Prof. Schorle.