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Tag: Linkoping University

  • Inequality in International Athletics: A Closer Look

    Inequality in International Athletics: A Closer Look

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    Newswise — Athletes from less affluent countries need more education on health to prevent injuries during hard training. But, paradoxically, more knowledge can also increase the risk of injury if there is no access to medically trained expertise. This is the conclusion of researchers at Linköping University, Sweden, in a new study on inequality in athletics.

    “There were astronomical differences in support resources between juniors from different parts of the world. European competitors had entire medical teams and computer-based analysis programs to aid them, while the main support for young East African competitors often consisted of a family member or teacher from their home village,” says Professor Toomas Timpka at the Department of Health, Medicine and Caring Sciences at Linköping University.

    The researchers have conducted studies among juniors and seniors who participated in two international athletics championships at elite level in 2017. In the final study recently published in the British Journal of Sports Medicine, 780 athletes from different countries were asked if they had experienced symptoms of injury during their preparations and, in that case, if this had led them to adapt their training. 

    They were also asked about their ability to independently acquire and use health knowledge to prevent injuries – something the researchers term health literacy. This is an area of which little is known.

    The researchers also used the UN’s annual development index, which ranks countries based on a number of factors, including education and income levels. This was used to estimate the medical support resources of the national teams. Taking development indices into account is new for research, according to Toomas Timpka.

    The differences in knowledge between adults and young people were shown to be great. Only 13 percent of the juniors were judged to have basic health literacy, compared with 41 percent of the adults. Regardless of age, athletes from countries with a high development index were more knowledgeable than competitors from other parts of the world.

    But the results also show that good individual knowledge is not all that matters. 

    When comparing athletes within a well-resourced national team, it was certainly shown to be more likely that those with good knowledge would reduce their training when feeling an injury than compatriots with less knowledge.
    But in more resource-poor national teams, such as the Kenyan team, the opposite was true. There, a knowledgeable person had a lower probability of reducing training compared to a less knowledgeable compatriot.

    The researchers conclude that knowledge in individual athletes is not enough. At worst, it can even cause them to overestimate their ability to make the correct judgement. What makes a difference is whether they have access to medically trained people for advice and support. But here, inequality is great between countries.

    In order to address the inequality in health literacy among young people, Toomas Timpka believes that World Athletics, the international athletics federation, should cooperate with the UN Development Programme. Then, everyone who dedicates themselves to athletics could get a school education that lives up to the global sustainability goals.

    Doing something about the unfair distribution of support resources is more difficult. Direct financial contributions unfortunately risk disappearing through corruption, according to Toomas Timpka. One possibility could be that the richer associations, through World Athletics, share their personnel and technical resources with less fortunate athletes ahead of major championships.

    The researchers have not investigated the consequences of the differences in support for the competitive results of the athletes. This will be followed up in connection with the World Athletics Championships in Budapest in the summer of 2023. 

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  • Ideal liquids for antioxidant-rich spinach smooth

    Ideal liquids for antioxidant-rich spinach smooth

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    Newswise — Different market products give very different results when it comes to liberating the antioxidant lutein from spinach in smoothies. Researchers at Linköping University, Sweden, have examined 14 common dairy and plant-based products and found that only four of these increased lutein liberation. Compared to water, some drinks had a negative effect on the lutein content in spinach smoothies.  

    Most people know that spinach is good for your health. One substance found in, for instance, spinach and kale is lutein. Several experimental studies have shown that lutein can suppress processes linked to inflammation, and there is now ample research indicating that chronic low-grade inflammation is an important risk factor in cardiovascular disease. 

    “Lutein is a bio-active compound. We have studied lutein in a similar way to studying a pharmaceutical drug. In this study, we looked at lutein liberation from fresh spinach,” says Rosanna Chung, assistant professor in the Department of Health, Medicine and Caring Sciences at Linköping University, who led the study published in Nutrients.

    As our bodies cannot produce lutein, the researchers behind the study were interested to find out how to optimise lutein intake from foods. The research group previously showed that preparation methods where the spinach is heated break down some of the lutein, whereas mixing it into a smoothie makes more lutein available for absorption. 

    The type of liquid used in the smoothie can also affect lutein content. As lutein dissolves in fat but not in water, it needs gastric juice and/or other food components to be liberated from the plant material and absorbed by our intestines. The researchers suspected that some components in our food, such as fat, carbohydrates, proteins and fibres, can affect the amount of lutein available for absorption. The effect of products such as yoghurt may also differ due to fermentation. However, products widely available on the market are rarely examined in scientific studies.   

    The researchers have examined the effects of various products available from food shops on the amount of lutein liberated in smoothies. Both dairy and plant-based liquids were tested.

    The researchers blended spinach with the various products. They then used a method simulating human digestion in the gastrointestinal tract, by adding digestive enzymes. Finally, the amount of lutein available for the body to absorb in smoothies made with various products was compared to that in smoothies made with just water. 

    “We could see that only 4 of the 14 examined products increased the liberation of lutein from spinach compared to water. Cow’s milk with a high fat content as well as coconut milk improved lutein liberation. Yoghurt, however, which is regarded as comparable to cow’s milk and is often used in cafés and similar, did not show particularly good results,” says Rosanna Chung.

    The fact that yoghurt is not that good at liberating lutein may have to do with the fermentation process. It also turned out that plant-based drinks, often made from nuts, legumes or oats, showed significantly different results.

    “Plant-based liquids have become increasingly common in smoothies. We saw that soymilk was actually less effective than water when it comes to liberating lutein in spinach smoothies. In other words, soymilk had a negative effect on lutein liberation in our study,” says Jan Neelissen, doctorate student and one of the researchers behind the study. 

    The other plant-based products in the study did not affect lutein liberation compared to water. As a general piece of information, smoothies should be consumed as soon as possible, because lutein breaks down quickly.

    It is important to note that whereas the results from this study indicate how much lutein is available for the body to absorb, no conclusions can be drawn as to how much lutein is actually absorbed. Therefore, the researchers will be conducting a human study in which they will measure the amount of lutein absorbed from smoothies made with different products.

    The study was supported by project grants from the Dr P Håkanssons Stiftelse, the Swedish Heart-Lung Foundation and the Swedish Research Council, and was carried out in collaboration with researchers at the Occupational and Environmental Medicine Unit of the University Hospital in Linköping.

    Article: The Effects of Dairy and Plant-Based Liquid Components on Lutein Liberation in Spinach Smoothies, Jan Neelissen, Per Leanderson, Lena Jonasson och Rosanna W. S. Chung, (2023), Nutrients, published online on 2 February 2023, Vol. 15, 779, doi: 10.3390/nu15030779

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  • COVID-19 reactivates several latent viruses – particularly in ME patients

    COVID-19 reactivates several latent viruses – particularly in ME patients

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    Newswise — COVID-19 reactivated viruses that had become latent in cells following previous infections, particularly in people with chronic fatigue syndrome, also known as ME/CFS. This is the conclusion of a study from Linköping University in Sweden. The results, published in Frontiers in Immunology, contribute to our knowledge of the causes of the disease and prospects of reaching a diagnosis.

    Severe, long-term fatigue, post-exertional malaise, pain and sleep problems are characteristic signs of myalgic encephalomyelitis/chronic fatigue syndrome, “ME/CFS”. The causes of the condition are not known with certainty, although it has been established that the onset in most cases follows a viral or bacterial infection. The health of the person affected is not restored even after the original infection is resolved. Indeed – the condition is sometimes known by its alternative name: post-viral fatigue. Since the cause is not known, diagnostic tests have not been developed.

    “This patient group has been neglected. Our study now shows that objective measurements are available that show physiological differences in the body’s reaction to viruses between ME patients and healthy controls,” says Anders Rosén, professor emeritus in the Department of Biomedical and Clinical Sciences (BKV) at Linköping University, and leader of the study.

    One theory that has been examined in several research studies is that a new infection can activate viruses that lie latent in the body’s cells after a previous infection. It has long been known that several herpes viruses, for example, can remain in a latent state in the body. Latent viruses can be reactivated many years later and give rise to a new bout of disease.

    It has, however, been difficult to determine whether such reactivated viruses are involved in ME/CFS – until now. The extensive spread of the SARS-CoV-2 coronavirus during the COVID-19 pandemic has given researchers a unique opportunity to study what happens in people with ME/CFS during a mild virus infection and compare this with what happens in healthy controls.

    In collaboration with the Bragée Clinic in Stockholm, the research group initiated a study early in the pandemic. Ninety-five patients who had been diagnosed with ME/CFS and 110 healthy controls participated in the study. They provided blood and saliva samples on four occasions during one year. The researchers analysed samples for antibodies against SARS-CoV-2 and latent viruses, and found a special fingerprint of antibodies against common herpes viruses in saliva. One of these viruses was the Epstein-Barr virus (EBV), which has infected nearly everybody. Most people experience a mild infection during childhood. People who are infected with EBV in the teenage years can develop glandular fever, commonly called mononucleosis, and also known as “kissing disease”. The virus then remains in a latent condition in the body. The EBV virus may proliferate in situations in which the immune system is impaired, causing fatigue, an autoimmune responses, and increased risk of lymphoma, if allowed to continue.

    Approximately half of the participants were infected with SARS-CoV-2 during the first wave of the pandemic and developed mild COVID-19 (58% of those with ME/CFS and 41% of the control group). In more than one third of cases, infection had been asymptomatic, so the person had not been aware of the infection. After the SARS-CoV-2 infection had passed, however, the researchers detected specific antibodies in the saliva that suggested that three latent viruses had been strongly reactivated, one of them being EBV. The reactivation was seen both in patients with ME/CFS and in the control group, but was significantly stronger in the ME/CFS group.

    Anders Rosén describes what happens as a domino effect: infection with a new virus, SARS-CoV-2, can activate other, latent, viruses in the body. The researchers suggest that this can, in turn, give rise to a chain reaction with an elevated immune response. This can have negative consequences, one of which is that the immune system attacks certain tissues, such as nerve tissue, in the body. Previous studies have also shown that the mitochondria, which produce energy in the cells, are affected, which suppresses the energy metabolism of people with ME/CFS.

    “Another important result from the study is that we see differences in antibodies against the reactivated viruses only in the saliva, not in the blood. This means that we should use saliva samples when investigating antibodies against latent viruses in the future,” says Anders Rosén.

    He points out that there is a great deal of overlap between the symptoms of ME/CFS and those of long COVID, which is experienced by around one third of patients who contract COVID-19. Exhaustion after light exercise, brain fog and unrefreshing sleep are common symptoms, while impaired lung capacity and abnormal senses of smell and taste are more specific for long COVID. The researchers believe that the results from the study can contribute to developing immunological tests to diagnose ME/CFS, and possibly also long COVID.

    “We now want to continue and carry out more detailed investigations into the immune response in ME/CFS, and in this way understand the differences between the antibody responses against latent viruses,” says Eirini Apostolou, principal research engineer, and lead author of the article.

    The study was financially supported by the Swedish Research Council, the Swedish Cancer Society and Linköping University. Some of the authors have financial interests in the Bragée Clinic.

    The article: Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic encephalomyelitis/chronic fatigue syndrome, Eirini Apostolou, Muhammad Rizwan, Petros Moustardas, Per Sjögren, Bo Christer Bertilson, Björn Bragée, Olli Polo and Anders Rosén, (2022), Frontiers in Immunology, published 20 October 2022, https://doi.org/10.3389/fimmu.2022.949787

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  • The road to future AI is paved with trust

    The road to future AI is paved with trust

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    Newswise — The place of artificial intelligence, AI, in our everyday life is increasing and many researchers believe that what we have seen so far is only the beginning. However, AI must be trustworthy in all situations. Linköping University is coordinating TAILOR, a EU project that has drawn up a research-based roadmap intended to guide research funding bodies and decision-makers towards the trustworthy AI of the future.

    “The development of artificial intelligence is in its infancy. When we look back at what we are doing today in 50 years, we will find it pretty primitive. In other words, most of the field remains to be discovered. That’s why it’s important to lay the foundation of trustworthy AI now,” says Fredrik Heintz, professor of artificial intelligence at LiU, and coordinator of the TAILOR project.

    TAILOR is one of six research networks set up by the EU to strengthen research capacity and develop the AI of the future. The foundation of trustworthy AI is being laid by TAILOR, by drawing up a framework, guidelines and a specification of the needs of the AI research community. “TAILOR” is an abbreviation of Foundations of Trustworthy AI – integrating, learning, optimisation and reasoning.

    The roadmap now presented by TAILOR is the first step on the way to standardisation, where the idea is that decision-makers and research funding bodies can gain insight into what is required to develop trustworthy AI. Fredrik Heintz believes that it is a good idea to show that many research problems must be solved before this can be achieved. 

    The researchers have defined three criteria for trustworthy AI: it must conform to laws and regulations, it must satisfy several ethical principles, and its implementation it must be robust and safe. Fredrik Heintz points out that these criteria pose major challenges, in particular the implementation of the ethical principles. 

    “Take justice, for example. Does this mean an equal distribution of resources or that all actors receive the resources needed to bring them all to the same level? We are facing major long-term questions, and it will take time before they are answered. Remember – the definition of justice has been debated by philosophers and scholars for hundreds of years,” says Fredrik Heintz.

    The project will focus on large comprehensive research questions, and will attempt to find standards that all who work with AI can adopt. But Fredrik Heintz is convinced that we can only achieve this if basic research into AI is given priority. 

    “People often regard AI as a technology issue, but what’s really important is whether we gain societal benefit from it. If we are to obtain AI that can be trusted and that functions well in society, we must make sure that it is centred on people,” says Fredrik Heintz.

    Many of the legal proposals written within the EU and its member states are written by legal specialists. But Fredrik Heintz believes that they lack expert knowledge within AI, which is a problem. 

    “Legislation and standards must be based on knowledge. This is where we researchers can contribute, providing information about the current forefront of research, and making well-grounded decisions possible. It’s important that experts have the opportunity to influence questions of this type,” says Fredrik Heintz.

    The complete roadmap is available at: Strategic Research and Innovation Roadmap of trustworthy AI

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