Cannabidiol & Cottonmouth — Can CBD Trigger A Dry Mouth Sensation? – Medical Marijuana Program Connection

Along with the “munchies” and red eyes, “cottonmouth” is a common side effect associated with cannabis use. Many people who use medical or recreational marijuana report feeling a dry mouth sensation. While most scientists believe this reaction is related chiefly to the psychoactive cannabinoid delta-9 THC, hemp fans are curious whether CBD could affect saliva production. Anyone new to CBD should know the likelihood they’ll experience “cottonmouth” when using hemp extracts.

As mentioned in the intro, most research into cannabis and dry mouth focuses on THC. Recent studies strongly suggest delta-9 THC interacts with CB1 receptors in the brain that can influence saliva secretion. However, current data from Argentina suggests other cannabinoids may play a role in reducing saliva.

Scientists at the University of Buenos Aires discovered many cannabinoid receptors in the human mouth. Not only does the endocannabinoid system (ECS) extend to our salivary glands, it appears these receptors account for approximately 65 percent of total saliva secretion.

Researchers went on to say that the compound anandamide has an antagonistic relationship with these saliva-producing cannabinoid receptors. Anandamide is a naturally-produced “endocannabinoid” that shares many traits with plant-extracted “phytocannabinoids” like THC and CBD. In fact, most researchers believe CBD oil can stimulate the production of anandamide.

If all of these findings are true, it may mean CBD…