The rigors of space travel could accelerate changes in the human body usually associated with aging. According to a new study of human tissues sent into low-Earth orbit,…
Read more Spaceflight Accelerates Aging of Human Stem Cells, Study FindsWhile scientists are still working to understand the effects an extended trip to space can have on the human body, research in recent years has suggested that astronauts…
Read more Human stem cells age more rapidly in space, study findsNewswise — Irvine, Calif., Dec. 7, 2023 — University of California, Irvine, researchers discovered a mechanism that controls the identity of stem cells. When this mechanism fails, embryonic…
Read more UC Irvine researchers discover a mechanism that controls the identity of stem cellsBACKGROUND Ferroptosis can induce low retention and engraftment after mesenchymal stem cell (MSC) delivery, which is considered a major challenge to the effectiveness of MSC-based pulmonary arterial hypertension…
Read more Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathwayIntervertebral disc (ID) degeneration (IDD) is one of the main causes of chronic low back pain, and degenerative lesions are usually caused by an imbalance between catabolic and…
Read more How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degenerationBACKGROUND Mesenchymal stem cells (MSCs) have great potential for the treatment of various immune diseases due to their unique immunomodulatory properties. However, MSCs exposed to the harsh inflammatory…
Read more Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cellsNewswise — Philadelphia, October 24, 2023 – Schizophrenia is a severe neuropsychiatric disease that remains poorly understood and treated. Schizophrenia onset is typically in adolescence or early adulthood, but its…
Read more Uncovering insights into the early stages of schizophrenia.BYLINE: Tessa Roy Newswise — Experts at the University of Michigan Health Rogel Cancer Center have found a potential solution for preventing a common and dangerous complication in patients that…
Read more Potato starch supplements could be solution to bone marrow transplant complicationsNew research published in the New England Journal of Medicine indicates that stem cell gene therapy may offer a promising, curative treatment for the painful, inherited blood disorder…
Read more New study shows promising evidence for sickle cell gene therapyNewswise — (SACRAMENTO, Calif.) — Ophthalmologists at UC Davis Health used an experimental gene therapy last month to treat a patient with wet age-related macular degeneration, or wet AMD.…
Read more UC Davis Eye Center tests experimental gene therapy for wet age-related macular degeneration (AMD)The art of constructing an insightful literature review manuscript has witnessed an exemplar in the work of Oz et al (2023), wherein concept progression harmoniously merges with figures…
Read more Mastering the craft: Creating an insightful and widely-cited literature reviewBACKGROUND The immunosuppressive capacity of mesenchymal stem cells (MSCs) is dependent on the “license” of several proinflammatory factors to express immunosuppressive factors such as programmed cell death 1…
Read more Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cord-derived mesenchymal stem cells by increasing PD-L1 expressionBACKGROUND Bone marrow mesenchymal stromal cells (BMSCs) are the commonly used seed cells in tissue engineering. Aryl hydrocarbon receptor (AhR) is a transcription factor involved in various cellular…
Read more Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cellsBACKGROUND Cardiovascular diseases particularly myocardial infarction (MI) are the leading cause of mortality and morbidity around the globe. As cardiac tissue possesses very limited regeneration potential, therefore use…
Read more Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivoBACKGROUND Intervertebral disc degeneration (IDD) is a main contributor to low back pain. Oxidative stress, which is highly associated with the progression of IDD, increases senescence of nucleus…
Read more Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axisBACKGROUND Local mesenchymal stem cell (MSC) therapy for complex perianal fistulas (PFs) has shown considerable promise. But, the long-term safety and efficacy of MSC therapy in complex PFs…
Read more Up-to-date meta-analysis of long-term evaluations of mesenchymal stem cell therapy for complex perianal fistulaNewswise — Myocardial infarction, the number one cause of sudden death in adults and the number two cause of death in Korea, is a deadly disease with an…
Read more Myocardial infarction, the number one cause of sudden death, may be treated by modulating the immune responseNewswise — BOSTON– A team led by researchers from Mass Eye and Ear, a member of Mass General Brigham, reports the results of a phase I trial of…
Read more Cell Therapy That Repairs Cornea Damage with Patient’s Own Stem Cells Achieves Positive Phase I Trial ResultsNewswise — Tsukuba, Japan—Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets. Their correct functioning…
Read more Enhanced stem cell culture boosts genome editing safety
