SANTA CLARA, Calif. — The Los Angeles Rams continue to lose offensive linemen to injury after center Coleman Shelton was ruled out of Monday’s game against the San Francisco 49ers with an ankle injury.

Shelton, who was the Rams’ backup center, injured his knee on the first drive of the game, but came back out for the Rams’ second offensive drive. He was later ruled out for the remainder of the game and replaced by Jeremiah Kolone.

The Rams are down to just two Week 1 starters on their offensive line after the injury. Shelton was playing in place of center Brian Allen, who injured his knee in the season opener. After the game, Rams head coach Sean McVay said he expected Allen to miss two to four weeks with the injury.

The Rams were also without guard David Edwards, who entered the concussion protocol on Saturday after telling the team that he “was a little bit foggy.” The Rams have lost five offensive linemen to injury at some point this season.

Rams quarterback Matthew Stafford had been sacked twice for a loss of 19 yards when Shelton was ruled out.

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