Tag: Cognition and Learning

Almost half of people with concussion still show symptoms of brain injury six months later

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Newswise — Even mild concussion can cause long-lasting effects to the brain, according to researchers at the University of Cambridge. Using data from a Europe-wide study, the team has shown that for almost a half of all people who receive a knock to the head, there are changes in how regions of the brain communicate with each other, potentially causing long term symptoms such as fatigue and cognitive impairment.

Mild traumatic brain injury – concussion – results from a blow or jolt to the head. It can occur as a result of a fall, a sports injury or from a cycling accident or car crash, for example. But despite being labelled ‘mild’, it is commonly linked with persistent symptoms and incomplete recovery. Such symptoms include depression, cognitive impairment, headaches, and fatigue.

While some clinicians in recent studies predict that nine out of 10 individuals who experience concussion will have a full recovery after six months, evidence is emerging that only a half achieve a full recovery. This means that a significant proportion of patients may not receive adequate post-injury care.

Predicting which patients will have a fast recovery and who will take longer to recover is challenging, however. At present, patients with suspected concussion will typically receive a brain scan – either a CT scan or an MRI scan, both of which look for structural problems, such as inflammation or bruising – yet even if these scans show no obvious structural damage, a patient’s symptoms may still persist.

Dr Emmanuel Stamatakis from the Department of Clinical Neurosciences and Division of Anaesthesia at the University of Cambridge said: “Worldwide, we’re seeing an increase in the number of cases of mild traumatic brain injury, particularly from falls in our ageing population and rising numbers of road traffic collisions in low- and middle-income countries.

“At present, we have no clear way of working out which of these patients will have a speedy recovery and which will take longer, and the combination of over-optimistic and imprecise prognoses means that some patients risk not receiving adequate care for their symptoms.”

Dr Stamatakis and colleagues studied fMRI brain scans – that is, functional MRI scans, which look at how different areas of the brain coordinate with each other – taken from 108 patients with mild traumatic brain injury and compared them with scans from 76 healthy volunteers. Patients were also assessed for ongoing symptoms.

The patients and volunteers had been recruited to CENTER-TBI, a large European research project which aims to improve the care for patients with traumatic brain injury, co-chaired by Professor David Menon (head of the division of Anaesthesia) and funded by the European Union.

In results published today in Brain, the team found that just under half (45%) were still showing symptoms resulting from their brain injury, with the most common being fatigue, poor concentration and headaches.

The researchers found that these patients had abnormalities in a region of the brain known as the thalamus, which integrates all sensory information and relays this information around the brain. Counter-intuitively, concussion was associated with increased connectivity between the thalamus and the rest of the brain – in other words, the thalamus was trying to communicate more as a result of the injury – and the greater this connectivity, the poorer the prognosis for the patient.

Rebecca Woodrow, a PhD student in the Department of Clinical Neuroscience and Hughes Hall, Cambridge, said: “Despite there being no obvious structural damage to the brain in routine scans, we saw clear evidence that the thalamus – the brain’s relay system – was hyperconnected. We might interpret this as the thalamus trying to over-compensate for any anticipated damage, and this appears to be at the root of some of the long-lasting symptoms that patients experience.”

By studying additional data from positron emission tomography (PET) scans, which can measure regional chemical composition of body tissues, the researchers were able to make associations with key neurotransmitters depending on which long-term symptoms a patient displayed. For example, patients experiencing cognitive problems such as memory difficulties showed increased connectivity between the thalamus and areas of the brain rich in the neurotransmitter noradrenaline; patients experiencing emotional symptoms, such as depression or irritability, showed greater connectivity with areas of the brain rich in serotonin.

Dr Stamatakis, who is also Stephen Erskine Fellow at Queens’ College, Cambridge, added: “We know that there already drugs that target these brain chemicals so our findings offer hope that in future, not only might we be able to predict a patient’s prognosis, but we may also be able to offer a treatment targeting their particular symptoms.”

Reference

Woodrow, RE et al. Acute thalamic connectivity precedes chronic postconcussive symptoms in mild traumatic brain injury. Brain; 26 April 2023; DOI: 10.1093/brain/awad056

ENDS

About the University of Cambridge

The University of Cambridge is one of the world’s leading universities, with a rich history of radical thinking dating back to 1209. Its mission is to contribute to society through the pursuit of education, learning and research at the highest international levels of excellence.

Cambridge was second in the influential 2023 QS World University Rankings, the highest rated institution in the UK.

The University comprises 31 autonomous Colleges and over 100 departments, faculties and institutions. Its 20,000 students include around 9,000 international students from 147 countries. In 2022, 72.5% of its new undergraduate students were from state schools and more than 25% from economically disadvantaged backgrounds.

Cambridge research spans almost every discipline, from science, technology, engineering and medicine through to the arts, humanities and social sciences, with multi-disciplinary teams working to address major global challenges. In the Times Higher Education’s rankings based on the UK Research Excellence Framework, the University was rated as the highest scoring institution covering all the major disciplines.

The University sits at the heart of the ‘Cambridge cluster’, in which more than 5,200 knowledge-intensive firms employ more than 71,000 people and generate £19 billion in turnover. Cambridge has the highest number of patent applications per 100,000 residents in the UK.

www.cam.ac.uk

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April 26, 2023
LaundryCares Offers Free Laundry and Literacy Day Events in Florida
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Newswise — OAKBROOK TERRACE, IL, March 10, 2023 – The LaundryCares Foundation welcomes the community of Gainesville, Florida, to experience a Free Laundry and Literacy Day event at two laundromat locations throughout the greater Gainesville area on Tuesday, March 28. Guests can enjoy complimentary laundry services and cleaning products plus free food and fun activities for children and adults from 4:00 p.m. to 6:00 p.m. There is no limit to the amount of clothing and linens that can be laundered – guests can bring as much as they want and wash it for free.

Participating laundromat locations include:
- Fresh Laundry, 3830 SW 13th St., Gainesville, FL 32608
- Wash King, 210 NE 16th Ave., Gainesville, FL 32602
The Fresh Laundry and Wash King locations will include “Family Read, Play, Learn” spaces for children to build language and learning skills in comfortable, engaging, language-rich environments. The “Family Read, Play, Learn” spaces are part of an initiative of the LaundryCares Foundation and Too Small to Fail which together formed the Laundry Literacy Coalition to help support young children’s early language development and help bridge the large child literacy gap across the country. Community members are encouraged to take advantage of the Free Laundry and Literacy Day events on Tuesday, March 28.

Local partners, including librarians from the Alachua County Library, will be onsite at both locations to provide interactive literacy activities and educational resources for families. Children can play educational games, participate in reading activities, and will receive a free book from Scholastic® to take home with them.

“Our organization is dedicated to helping under-resourced neighborhoods by making literacy and learning attainable,” said Dan Naumann, Executive VP, LaundryCares Foundation. “The Free Laundry and Literacy Day events are an important recognition of a growing U.S. population with children and families who often find it challenging to have basic needs met.”

The LaundryCares Foundation works with laundromat owners and community organizations throughout the U.S. to connect communities with literacy resources in safe, clean, and comfortable settings within laundromats. Interested parties can enroll in the LaundryCares Network at no charge to become part of the movement that’s helping to bridge the large child literacy gap at local laundromats in historically excluded communities.

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About the LaundryCares Foundation

The LaundryCares Foundation is dedicated to enriching communities through the coordinated efforts of local businesses, community leaders and individuals to help better the lives of their neighbors. Since 2006, LaundryCares’ three pillars of philanthropy include offering free laundry services, support of key literacy skills in early childhood development, and disaster relief assistance.

The LaundryCares Foundation is the philanthropic arm of the Coin Laundry Association (CLA) a national, nonprofit organization, with a membership of more than 300 manufacturers and distributors, and 1,500 owners in the self-service laundry industry. For more information about the LaundryCares Foundation, visit laundrycares.org.

About Too Small to Fail

Too Small to Fail, the early childhood initiative of the Clinton Foundation, promotes early brain and language development by supporting parents and caregivers with tools to talk, read, and sing with their young children from birth. Today, almost 60 percent of children in the United States start kindergarten unprepared, lagging behind their peers in critical language and reading skills. Through partnerships with pediatricians, hospitals, faith-based leaders, community-based organizations, businesses, entertainment industry leaders, and others, Too Small to Fail is meeting parents where they are to help them prepare their children for success in school and beyond. Whether at the pediatrician’s office or the playground, Too Small to Fail aims to make small moments big by creating opportunities for meaningful interactions anytime, anywhere. Learn more at www.toosmall.org.
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March 10, 2023
NFL players who experienced concussion symptoms during careers show reduced cognitive performance decades after retirement

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Newswise — Former professional football players who reported experiencing concussion symptoms during their playing careers were found to perform worse on a battery of cognitive tests than non-players, according to a study led by Mass General Brigham investigators from McLean Hospital and Spaulding Rehabilitation Network. Results of the study are published March 2^nd in Archives of Clinical Neuropsychology.[JR1]

Of the more than 350 former National Football League (NFL) players who were studied an average of 29 years after their playing career ended, those who reported experiencing concussion symptoms during their careers scored worse on assessments of episodic memory, sustained attention, processing speed and vocabulary. However, the number of concussions diagnosed by a medical professional or length of playing career had no observed effect on cognition.

A follow-up analysis compared the former players to more than 5,000 male volunteers in the general population who did not play professional football, which found that cognitive performance was generally worse for former players than nonplayers. While younger former players outperformed nonplayers on some tests, older retired players more likely to perform worse than controls on cognitive tasks.

The researchers who led the study said that their results underline the importance of tracking concussion symptoms as opposed to diagnosed concussions in research. This work also adds evidence to the impact a professional football career can have on accelerating cognitive aging.

“It is well-established that in the hours and days after a concussion, people experience some cognitive impairment. However, when you look decades out, the data on the long-term impact have been mixed,” said study senior author Laura Germine, PhD, director of the Laboratory for Brain and Cognitive Health Technology at McLean Hospital and associate professor of psychiatry at Harvard Medical School. “These new findings from the largest study of its kind show that professional football players can still experience cognitive difficulties associated with head injuries decades after they have retired from the sport.”

Concussion Symptoms Linked to Cognitive Performance

For the study, 353 retired NFL players completed hour-long neuropsychological tests through an online platform called TestMyBrain, which is supported by McLean Hospital and Harvard Medical School. Players were fully remote and completed tests on a laptop or desktop that included assessments that measured processing speed, visual-spatial and working memory, and aspects of short- and long-term memory and vocabulary.

Recollected concussion symptoms were measured by asking the players the number of times they experienced any one of the following symptoms following a blow to the head during play or practice: headaches, nausea, dizziness, loss of consciousness, memory problems, disorientation, confusion, seizure, visual problems or feeling unsteady on their feet. They were also asked whether they lost consciousness during their careers, and whether they were ever diagnosed with a concussion by a medical professional.

The results showed that the former players’ cognitive performance (for example, on memory tasks) was associated with recalled football concussion symptoms. For example, differences observed in visual memory scores between former players with the highest and lowest reported concussion symptoms were equivalent to the differences in cognitive performance between a typical 35-year-old and 60-year-old.

However, poor cognitive performance was not associated with diagnosed concussions, years of professional play or age of first football exposure. The researchers noted that many head injuries or sub-concussive blows may not have been diagnosed as concussions due to a lack of awareness at the time or underreporting of symptoms by players.

When comparing the retired players to a group of 5,086 men who did not play football, cognitive performance was generally worse for former players. On two tests of processing speed, age-related differences in cognitive performance were larger among the former player group than the nonplayer group, with older players performing worse.

These comparison data suggest that football exposure might accelerate age-related cognitive declines and produce greater disadvantages at older ages, according to the researchers, who added that more studies are needed to track cognitive performance in former players as they age. Another possibility is that improved awareness and management of head injuries may have spared younger retired players more than older ones. The researchers also noted that this comparative finding is limited by a lack of data on cognition prior to head injuries, and that more research is needed that closely matches former players and nonplayers and measures their cognitive performances across their lifetimes.

“For both former players and researchers, we can glean some important takeaways from this study,” said principal investigator of the Football Players Health Study, Ross Zafonte, DO. “Former players can support their cognitive health as they age by taking proactive steps, and continuing to consult with their providers and educate themselves on symptoms of head injury. For researchers and providers, these findings support efforts to develop ways to enhance diagnosis and define long-term sequalae of concussion.” Zafonte is president of Spaulding Rehabilitation Network, a Mass General Brigham sports medicine physician, and the Earle P. and Ida S. Charlton Professor and Chair of the Harvard Medical School Department of Physical Medicine and Rehabilitation.

“The Community Based Participatory Research (CBPR) approach taken in this study is where this field is heading,” said Germine. “We are grateful to the players and how much they have taught us. It would not have been possible to do a study like this without engaging and deeply involving their community.”

Research Driven by Input from Former NFL Players

The Football Players Health Study at Harvard University, launched in 2014, is a comprehensive research program dedicated to examining the multifactorial causes that impact the health of former NFL players. The research has been informed by the players themselves, who have provided input on the health concerns and conditions they face after a career in football. An interdisciplinary team of researchers from Harvard University and Harvard Medical School and its affiliated teaching hospitals, including those in the Mass General Brigham system, conduct research from neurology, cardiology, sports medicine, rehabilitation medicine, chronic pain and public health. While concussion and head injury are of paramount concern, the study examines all aspects of player health across the life span. Former players can find important resources to support their health in this section of the study’s website.

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This work was supported by the Football Players Health Study at Harvard University, which is funded by the National Football League Players Association (NFLPA). The content is solely the responsibility of the authors, and does not necessarily represent the official views of Harvard Medical School, Harvard University, and its affiliated academic healthcare centers. The NFLPA had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.

In addition to Drs. Germine and Zafonte, other investigators on the study included Roger W. Strong, PhD, Rachel Grashow, PhD, MS, Andrea L. Roberts, PhD, Eliza Passell, BA, Luke Scheuer, BA, Douglas P. Terry, PhD, Sarah Cohan, PMP, Alvaro Pascual-Leone, MD, PhD and Marc G. Weisskopf PhD, ScD.

Paper cited: Strong RW et al. “Association of retrospectively reported concussion symptoms with objective cognitive performance in former American-style football players” Archives of Clinical Neuropsychology DOI: 10.1093/arclin/acad008.

About Mass General Brigham

Mass General Brigham is an integrated academic healthcare system, uniting great minds in medicine to make life-changing impact for patients in our communities and people around the world. Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services. Mass General Brigham is a non-profit organization that is committed to patient care, research, teaching, and service to the community. In addition, Mass General Brigham is one of the nation’s leading biomedical research organizations and a principal teaching affiliate of Harvard Medical School. For more information, please visit massgeneralbrigham.org.

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March 3, 2023
Happy birthday to Dr. Seuss: FSU literacy researcher offers tips to get kids reading

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BYLINE: Kathleen Haughney

Newswise — With school-aged children celebrating the joy of reading through Read Across America Day or Dr. Seuss Day this week, many parents and teachers are capitalizing on that joy to remind kids of the power of a good book.

Florida State University Assistant Professor Lakeisha Johnson, a faculty affiliate for The Florida Center for Reading Research, has assembled a tip sheet for parents using this time to encourage their children to read more.

“Sometimes, finding the right book or format can light a spark that will stay with children forever,” Johnson said.

Here are some tips:

Let your child lead.
Allow your child to choose books based on their interests. Whether they like picture books or graphic novels, fiction or biographies, poetry or sci-fi, children are more motivated to read when they are interested in the topic.

Make reading a family activity.
Choose a time of day when all members of the family drop everything and read. Children often follow the models shown by adults and will value reading when they see their grown-ups doing it for pleasure.

Keep reading aloud.
Read books together, even when your child is old enough to read on their own. When grown-ups read aloud, the mental space needed to decode is freed up and the child can focus solely on understanding the story and actively participating in conversations beyond the text.

Introduce a fun series.
No one likes a cliffhanger. Captivating series are a great way to keep children engaged and wanting to read the next story.

Go beyond storybooks.
Reading doesn’t always have to be a traditional book. Read through a recipe book to find a new meal or dessert idea. Find a children’s magazine to spark interest in a new topic. Try listening to audiobooks for a fun switch in your normal reading routine.

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March 1, 2023
Cockatoos know to bring along multiple tools when they fish for cashews

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Newswise — Goffin’s cockatoos have been added to the short list of non-human animals that use and transport toolsets. In a study publishing in the journal Current Biology on February 10, researchers show that the cockatoos carry multiple tools to their worksite when the job calls for it. This behavior has only been previously reported in chimpanzees, our closest relatives.

Goffin’s cockatoos are small white parrots that hail from the Tanimbar Islands archipelago in Indonesia. Captive Goffin’s cockatoos use and manufacture tools, and a recent study of wild-caught cockatoos reported that they can use up to three different tools to extract seeds from a particular fruit. Up until now, though, it wasn’t clear whether the cockatoos considered these tools as a “set”; it’s possible that what may look like a toolset is instead nothing more than a chain of single tool uses, with the need for each new tool appearing to the animal as the task evolves.

Now, a team of researchers have used controlled experiments to clarify that the cockatoos do indeed recognize when a job requires more than one tool. “With this experiment we can say that, like chimpanzees, Goffin’s cockatoos not only appear to be to using toolsets, but they know that they are using toolsets,” says first author Antonio Osuna-Mascaró, an evolutionary biologist at the University of Veterinary Medicine Vienna. “Their flexibility of behavior is stunning.”

Osuna-Mascaró was inspired by the termite-fishing Goualougo Triangle chimpanzees of northern Congo, the only other known non-human animal to use toolsets. These chimpanzees fish for termites via a two-step process: first, they use a blunt stick to break holes in the termite mound, and then they insert a long, flexible probe to “fish” the termites out of the holes. In this study, Osuna-Mascaró’s team tasked the cockatoos with fishing for cashews instead of termites.

To mimic the termite-fishing set-up, the researchers presented the cockatoos with a box containing a cashew behind a transparent paper membrane. To reach the cashew, the cockatoos had to punch through the membrane and then “fish” the cashew out. They were provided with a short, pointy stick for punching holes and a vertically halved plastic straw for fishing.

Seven of the ten cockatoos tested taught themselves to extract cashews successfully by punching through the membrane, and two of the cockatoos (Figaro and Fini) completed the task within 35 seconds on their first attempt. The cockatoos don’t have an equivalent foraging behavior in the wild, so there was no chance that their tool use was based on innate behaviors, and each cockatoo used a slightly different technique.

Next, the team tested the cockatoos’ ability to change their tool use in a flexible manner depending on the situation. To do this, they presented each cockatoo with two different types of box: one with a membrane and one without. The cockatoos were given the same two tools, but they only needed the pointy stick when a membrane was in the way. “The cockatoos had to act according to the problem; sometimes the toolset was needed, and sometimes only one tool was enough,” says Osuna-Mascaró.

All of the cockatoos mastered the test in a very short period of time and were able to recognize when a single tool was sufficient. However, the birds engaged in an interesting behavior during this choosing phase. “When making the choice between which tool to use first, they were picking one up, releasing it, then picking up the other one, releasing it, returning to the first one, and so on,” says Osuna-Mascaró. The researchers found that when cockatoos did this switching, they performed better on the tests.

Next, the team tested the cockatoos’ ability to transport the tools as a set on an as-needed basis. They put the cockatoos through a series of increasingly challenging trials to reach the boxes: first they had to climb a short ladder while carrying their tools; then they had to fly horizontally with them; and in the final test, they had to carry the tools while flying vertically. As before, the birds were only sometimes presented with a box with a membrane barrier, so they had to decide whether the problem required one or both tools.

Some cockatoos learned to carry the two tools together—by inserting the short punching stick into the groove of the halved straw—when they were presented with a box that required both. This meant they only had to make one trip, albeit while carrying a heavier toolset. Most of the cockatoos transported the toolset on an as-needed basis, further indicating that they knew ahead of time when two tools were required, though some made two trips when necessary. One cockatoo, Figaro, decided not to waste time thinking and instead carried both tools in almost every trial.

“We really did not know whether the cockatoos would transport two objects together,” says Alice Auersperg, senior author on the study and a cognitive biologist at the University of Veterinary Medicine Vienna. “It was a little bit of a gamble because I have seen birds combining objects playfully, but they very rarely transport more than one object together in their normal behavior.”

There’s a lot more to be learned about cockatoo tool use, the researchers say. “We feel that, in terms of technical cognition and tool use, parrots have been underestimated and understudied,” says Auersperg.

“We’ve learned how dexterous the cockatoos are when using a toolset, and we have a lot of things to follow-up on,” says Osuna-Mascaró. “The switching behavior is very interesting to us, and we are definitely going to use it to explore their decision making and their metacognition—their ability to recognize their own knowledge.”

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This research was supported by the Vienna Science and Technology Fund and the Austrian Science Fund.

Current Biology, Osuna-Mascaró et al. “Flexible tool set transport in Goffin’s cockatoos,” https://www.cell.com/current-biology/fulltext/S0960-9822(23)00057-X

Current Biology (@CurrentBiology), published by Cell Press, is a bimonthly journal that features papers across all areas of biology. Current Biology strives to foster communication across fields of biology, both by publishing important findings of general interest and through highly accessible front matter for non-specialists. Visit: http://www.cell.com/current-biology. To receive Cell Press media alerts, contact [email protected].

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February 10, 2023
“It’s me!” fish recognizes itself in photographs

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Newswise — A research team led by Specially Appointed Professor Masanori Kohda from the Graduate School of Science at the Osaka Metropolitan University has demonstrated that fish think “it’s me” when they see themselves in a picture, for the first time in animals. The researchers found that the determining factor was not seeing their own body but seeing their face. These findings have been published in the Proceedings of the National Academy of Sciences.

In this study, relevant experiments were conducted with Labroides dimidiatus, commonly known as a cleaner fish, which are known to be able to recognize themselves in mirrors and regularly attack other unfamiliar cleaner fish who intrude on their territory. Each cleaner fish was presented with four photographs: a photo of themselves; a photo of an unfamiliar cleaner; a photo of their own face on an unfamiliar cleaner’s body; and a photo of unfamiliar cleaner’s face on their own body. Interestingly, the cleaner fish did not attack photos with their own faces but did attack those with the faces of unfamiliar cleaner fish. Together these results indicate that the cleaner fish determined who was in the photograph based on the face in the photo but not the body in the similar way humans do.

To negate the possibility that the fish considered photographs of themselves as very close companions, a photograph mark-test was conducted. Fish were presented with a photograph where a parasite-like mark was placed on their throat. Six of the eight individuals that saw the photograph of themselves with a parasite mark were observed to rub their throats to clean it off. While showing those same fish pictures of themselves without parasite marks or of a familiar cleaner fish with parasite marks did not cause them to rub their throats.

“This study is the first to demonstrate that fish have an internal sense of self. Since the target animal is a fish, this finding suggests that nearly all social vertebrates also have this higher sense of self,” stated Professor Kohda.

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About OMU

Osaka Metropolitan University is a new public university established by a merger between Osaka City University and Osaka Prefecture University in April 2022. For more science news, see https://www.omu.ac.jp/en/, and follow @OsakaMetUniv_en and #OMUScience.

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February 10, 2023
Brain area necessary for fluid intelligence identified

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Newswise — A team led by UCL and UCLH researchers have mapped the parts of the brain that support our ability to solve problems without prior experience – otherwise known as fluid intelligence.

Fluid intelligence is arguably the defining feature of human cognition. It predicts educational and professional success, social mobility, health, and longevity. It also correlates with many cognitive abilities such as memory.

Fluid intelligence is thought to be a key feature involved in “active thinking” – a set of complex mental processes such as those involved in abstraction, judgment, attention, strategy generation and inhibition. These skills can all be used in everyday activities – from organising a dinner party to filling out a tax return.

Despite its central role in human behaviour, fluid intelligence remains contentious, with regards to whether it is a single or a cluster of cognitive abilities, and the nature of its relationship with the brain.

To establish which parts of the brain are necessary for a certain ability, researchers must study patients in whom that part is either missing or damaged. Such “lesion-deficit mapping” studies are difficult to conduct owing to the challenge of identifying and testing patients with focal brain injury.

Consequently, previous studies have mainly used functional imaging (fMRI) techniques – which can be misleading.

The new study, led by UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery at UCLH researchers and published in Brain, investigated 227 patients who had suffered either a brain tumour or stroke to specific parts of the brain, using the Raven Advanced Progressive Matrices (APM): the best-established test of fluid intelligence. The test contains multiple choice visual pattern problems of increasing difficulty. Each problem presents an incomplete pattern of geometric figures and requires selection of the missing piece from a set of multiple possible choices.

The researchers then introduced a novel “lesion-deficit mapping” approach to disentangle the intricate anatomical patterns of common forms of brain injury, such as stroke.

Their approach treated the relations between brain regions as a mathematical network whose connections describe the tendency of regions to be affected together, either because of the disease process or in reflection of common cognitive ability.

This enabled researchers to disentangle the brain map of cognitive abilities from the patterns of damage – allowing them to map the different parts of the brain and determine which patients did worse in the fluid intelligence task according to their injuries.

The researchers found that fluid intelligence impaired performance was largely confined to patients with right frontal lesions – rather than a wide set of regions distributed across the brain. Alongside brain tumours and stroke, such damage is often found in patients with a range of other neurological conditions, including traumatic brain injury and dementia.

Lead author, Professor Lisa Cipolotti (UCL Queen Square Institute of Neurology), said: “Our findings indicate for the first time that the right frontal regions of the brain are critical to the high-level functions involved in fluid intelligence, such as problem solving and reasoning.

“This supports the use of APM in a clinical setting, as a way of assessing fluid intelligence and identifying right frontal lobe dysfunction.

“Our approach of combining novel lesion-deficit mapping with detailed investigation of APM performance in a large sample of patients provides crucial information about the neural basis of fluid intelligence. More attention to lesion studies is essential to uncover the relationship between the brain and cognition, which often determines how neurological disorders are treated.”

The study was funded by Welcome and the NIHR UCLH Biomedical Research Centre funding scheme. Researchers also received funding from The National Brain Appeal and the Guarantors of Brain.

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December 28, 2022
Researchers uncover factors linked to optimal aging

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Newswise — What are the keys to “successful” or optimal aging? A new study followed more than 7000 middle aged and older Canadians for approximately three years to identify the factors linked to well-being as we age.

They found that those who were female, married, physically active and not obese and those who had never smoked, had higher incomes, and who did not have insomnia, heart disease or arthritis, were more likely to maintain excellent health across the study period and less likely to develop disabling cognitive, physical, or emotional problems.

As a baseline, the researchers selected participants who were in excellent health at the start of the approximately three-year period of study. This included the absence of memory problems or chronic disabling pain, freedom from any serious mental illness and absence of physical disabilities that limit daily activities — as well as the presence of adequate social support and high levels of happiness and life satisfaction.

“We were surprised and delighted to learn that more than 70% of our sample maintained their excellent state of health across the study period,” says the first author, Mabel Ho, a doctoral candidate at the University of Toronto’s Factor-Inwentash Faculty of Social Work (FIFSW) and the Institute of Life Course and Aging. “Our findings underline the importance of a strength-based rather than a deficit-based focus on aging and older adults. The media and research tend to ignore the positive and just focus on the problems.”

There was considerable variation in the prevalence of successful aging based on the respondents’ age at the beginning of the study. Three quarters of the respondents who were aged 55 to 64 at the start of the study period maintained excellent health throughout the study. Among those aged 80 and older, approximately half remained in excellent health.

“It is remarkable that half of those aged 80 and older maintained this extremely high bar of cognitive, physical, and emotional well-being across the three years of the study. This is wonderful news for older adults and their families who may anticipate that precipitous decline is inevitable for those aged 80 and older.” says Mabel Ho. “By understanding factors associated with successful aging, we can work with older adults, families, practitioners, policymakers, and researchers to create an environment that supports a vibrant and healthy later life.”

Older adults who were obese were less likely to maintain good health in later life. Compared to older adults who were obese, those who had a normal weight were 24% more likely to age optimally.

“Our findings are in keeping with other studies which have found that obesity was related to a range of physical symptoms and cognitive problems and that physical activity also plays a key role in optimal aging,” says co-author David Burnes, Associate Professor at the University of Toronto’s FIFSW and a Canada Research Chair in Older Adult Mistreatment Prevention. “These findings highlight the importance of maintaining an appropriate weight and engaging in an active lifestyle throughout the life course”.

Income was also as an important factor. Only about half of those below the poverty line aged optimally compared to three-quarters of those living above the poverty line.

“Although our study does not provide information on why low income is important, it is possible that inadequate income causes stress and also restricts healthy choices such as optimal nutrition. Future research is needed to further explore this relationship,” says senior author Esme Fuller-Thomson, Director of the Institute for Life Course & Aging and Professor at the University of Toronto’s Factor-Inwentash Faculty of Social Work.

Lifestyle factors are associated with optimal health in later life. Older adults who never smoked were 46% more likely to maintain an excellent state of health compared to current smokers. Previous studies showed that quitting smoking in later life could improve survival statistics, pulmonary function, and quality of life; lower rates of coronary events, and reduce respiratory symptoms. The study found that former smokers did as well as those who had never smoked, underscoring that it is never too late to quit.

The study also found that engaging in physical activity was important in maintaining good health in later life. Older adults who engaged in moderate to strenuous physical activity were 35% to 45% more likely to age well, respectively.

The findings indicated that respondents who never or rarely experienced sleep problems at baseline were 29% more likely to maintain excellent health across the study.

“Clearly, good sleep is an important factor as we age. Sleep problems undermine cognitive, mental, and physical health. There is strong evidence that an intervention called cognitive-behavioral therapy for insomnia (CBT-I) is very helpful for people living with insomnia,” says Esme Fuller-Thomson.

The study was recently published online, in the International Journal of Environmental Research and Public Health. It uses longitudinal data from the baseline wave (2011-2015) and the first follow-up wave (2015-2018) of data from the Canadian Longitudinal Study on Aging (CLSA) to examine factors associated with optimal aging the first two waves. In the CLSA, there were 7,651 respondents who were aged 60 years or older at wave 2 who were in optimal health during the baseline wave of data collection. The sample was restricted to those who were in excellent health at baseline, which was only 45% of the respondents.

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University of Toronto

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December 13, 2022
Improvisation and creativity in professional jazz musicians
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Newswise — World-renowned jazz musicians are often praised for their creative ingenuity. But how do they make up improvisations? And what makes artists’ solos more enticing than those of less skilled players? These questions continue to puzzle not only jazz aficionados, but also psychological researchers. Two leading theories have dominated so far: Either musicians learn to master rules telling them what they can and cannot play – a sort of “secret language of jazz.” Or, each musician builds up a personal library of melodic patterns – “licks” – that they can draw upon and recombine in new and interesting ways. Over the years, musical scholars have collected many such volumes of “licks” for learners to practice. Yet, the fact that a certain combination of notes recurs many times is no proof of an underlying movement pattern stored in the brains of musicians—it could just be a sheer coincidence.

The ‘library theory’ of jazz improvisation
A new scientific study, just published in the journal Cognition, provides the first solid psychological evidence for the library theory of jazz improvisation. For the first time ever, researchers from Aarhus University and Georgia State University found that expert jazz musicians play certain note combinations with much more consistent timing and force than others. Regardless if these “licks” were played fast or slow, loud or soft, the relative rhythms and accents remained very similar. This strongly suggests that each player possesses a collection of patterns that are directly grounded in their own body and brain. Many jazz experts have called it their personal “vocabulary.” Interestingly, the new study found that these improvisation vocabularies vary between different players.

Martin Norgaard, born and raised in Denmark, now Associate Professor of Music Education at Geogia State University in Atlanta comments further: “It is fascinating that expert jazz musicians store linked audio and motor representations in the brain – that is both the sound of licks and information about how to play them. As a jazz violinist myself, I often hear licks I want to play while improvising but the motor representation is not complete so the lick doesn’t come out right. Based on our research, that should happen less as expertise develops.”

Stylistically appropriate and novel – hallmarks of creativity
Using an advanced computer model, the researchers furthermore showed that “licks” tend to occur in relatively predictable contexts but simultaneously evoke greater surprise and uncertainty in the listener. This finding fits well with leading theories in psychology and neuroscience about human creativity and what makes certain types of music particularly enjoyable to listen to. Specifically, melodies in the personal vocabularies of jazz improvisers are typically both stylistically appropriate and novel—the two hallmarks of creativity according to scientists.

“The fact that the solos of jazz experts evoke strong expectations in listeners and simultaneously surprise them might be exactly what makes these melodies so catchy and memorable. This may ultimately help us understand why some musicians become famous while others don’t,” said senior author Niels Chr. Hansen, Assistant Professor at Aarhus Institute of Advanced Studies at Aarhus University, Denmark.

The research results – how did they do it?
- The researchers analysed nearly 100,000 notes played on a MIDI keyboard by the artist-level jazz pianist Kevin Bales, during 11 live music gigs for audiences in the United States. This collection of solos was compared to recordings of 25 experienced jazz pianists taking part in a previous laboratory experiment.
- For each recurring 5-note sequence, the durations of notes and the force with which they were played were compared across versions of the same pattern to find the set of licks that were played the most consistently across different tempi and loudness.
- A computational model was trained on the Weimar Jazz Database consisting of more than 200,000 notes from 456 improvised songs by various jazz artists to estimate how much surprise and uncertainty each note in Kevin Bales’ improvised solos would evoke in an average jazz listener.
Where can I find the scientific article?
- Download: Until 18 December 2022, the article can be accessed freely via this link: https://authors.elsevier.com/c/1f-OF2Hx2pj8N
- Citation: Norgaard, M., Bales, K., & Hansen, N.C. (2023). Linked auditory and motor patterns in the improvisation vocabulary of an artist-level jazz pianist. Cognition, 230. doi:10.1016/j.cognition.2022.105308
Funding

The study has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 754513 and The Aarhus University Research Foundation.
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Aarhus University

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November 18, 2022
Long-term study supports link between inflammation and cognitive problems in older breast cancer survivors

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Newswise — LOS ANGELES – Scientists are still trying to understand why many breast cancer survivors experience troubling cognitive problems for years after treatment. Inflammation is one possible culprit. A new long-term study of older breast cancer survivors published today in the Journal of Clinical Oncology and co-led by UCLA researchers adds important evidence to that potential link.

Higher levels of an inflammatory marker known as C-reactive protein (CRP) were related to older breast cancer survivors reporting cognitive problems in the new study.

“Blood tests for CRP are used routinely in the clinic to determine risk of heart disease. Our study suggests this common test for inflammation might also be an indicator of risk for cognitive problems reported by breast cancer survivors,” said study lead author Judith Carroll, an associate professor of psychiatry and biobehavioral sciences and faculty member of the Cousins Center for Psychoneuroimmunology at UCLA. 

The study, called the Thinking and Living with Cancer (TLC) Study, is one of the first long-term efforts to examine the potential link between chronic inflammation and cognition in breast cancer survivors 60 and older, who make up a majority of the nearly 4 million breast cancer survivors in the United States. Previous research has focused largely on younger women and women immediately after therapy, making it difficult to draw conclusions about CRP’s role in long-term cognitive problems among older breast cancer survivors. 

In TLC, teams of researchers from around the country talked to, and obtained blood samples from, hundreds of breast cancer survivors and women without cancer up to 6 times over the course of 5 years. The study was motivated by hearing from survivors and advocates that cognitive problems are one of their major worries.

“Cognitive issues affect women’s daily lives years after completing treatment, and their reports of their own ability to complete tasks and remember things was the strongest indicator of problems in this study,” said co-senior study author Dr. Jeanne Mandelblatt, a professor of oncology at Georgetown University who is the lead of the TLC study.

“Being able to test for levels of inflammation at the same time that cognition was being rigorously evaluated gave the TLC team a potential window into the biology underlying cognitive concerns,” said Elizabeth C. Breen, a professor emerita of psychiatry and biobehavioral sciences at the Cousins Center for Psychoneuroimmunology at UCLA, who also served as co-senior study author.

Cognition, from the perspective of each woman, was evaluated through a commonly used questionnaire assessing how the women perceive their ability to remember things like names and direction, ability to concentrate, and other aspects of everyday life. The study found higher CRP levels among survivors were predictive of lower reported cognitive function among breast cancer survivors. There was no similar relationship between CRP levels and reported cognition in the women without cancer.

Cognitive performance, as measured by standardized neuropsychological tests, failed to show a link between CRP and cognition. The authors say this may indicate women are more sensitive to differences in their everyday cognitive function, self-reporting changes that other tests miss.

The authors said their study supports the need for research on whether interventions that can lower inflammation – including increased physical activity, better sleep, and anti-inflammatory medications – may prevent or reduce cognitive concerns in older breast cancer survivors. 

Other study authors include Zev M. Nakamura, Brent J. Small, Xingtao Zhou, Harvey J. Cohen, Tim A. Ahles, Jaeil Ahn, Traci N. Bethea, Martine Extermann, Deena Graham, Claudine Isaacs, Heather S.L. Jim, Paul B. Jacobsen, Brenna C. McDonald, Sunita K. Patel, Kelly Rentscher, James Root, Andrew J. Saykin, Danielle B. Tometich, Kathleen Van Dyk, and Wanting Zhai. The authors declared no conflicts of interest.  

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University of California, Los Angeles (UCLA), Health Sciences

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September 30, 2022